トップ研究者を探す動脈硬化プラーク脆弱化の分子機構の解明と急性冠症候群予測因子の同定

動脈硬化プラーク脆弱化の分子機構の解明と急性冠症候群予測因子の同定

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22390159
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 徳島大学
代表研究者 佐田 政隆
研究分担者 添木 武
研究分担者 平田 恭信
研究分担者 黒部 裕嗣
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 18,720,000 (直接経費 :14,400,000、間接経費 :4,320,000)
配分額(履歴) 2012年度:5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
2011年度:5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
2010年度:8,060,000 (直接経費 :6,200,000、間接経費 :1,860,000)
キーワード 動脈硬化
血管新生
慢性炎症
HMGB-1
急性冠症候群プラーク破裂
循環器・高血圧
急性冠症候群
プラーク破裂
プラーク
自然免疫
マクロファージ
サイトカイン
生活習慣病

研究成果

[雑誌論文] Spectacular migration of a central venous catherter into the pulmonary artery.

Tomoya Hara 2013

[雑誌論文] Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.

Hirotsugu Kurobe 2013

[雑誌論文] Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.

Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y. 2013

[雑誌論文] Constrictive Pericarditis With Intrapericardial Abscess

H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M 2013

[雑誌論文] Patent foramen ovale diagnosed by real-time three-dimensional contrast transesophageal echocardiography: A case report.

Noriko Tomita 2013

[雑誌論文] Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure.

Kusunose K, Yamada H, Nishio S, Tomita N, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M 2013

[雑誌論文] Ulcer-like projection caused by a penetrating branch to the bronchial artery.

Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M. 2013

[雑誌論文] Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.

Naoko Kawano 2013

[雑誌論文] Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein

Tomoya Hara 2013

[図書] 4. 治療薬総論 硝酸薬』 今日の循環器疾患治療指針 第3 版(井上博、許俊鋭、檜垣實男、代田浩之、筒井裕之 編

竹谷善雄、佐田政隆 2013

[雑誌論文] Expanded roles of the renin-angiotensin system.

Daiju Fukuda 2013

[雑誌論文] Defects of vascular nitric oxide bioavailability in subjects with impaired glucose tolerance: A potential link to insulin resistance.

Michio Shimabukuro 2013

[雑誌論文] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion.

Tomoya Hara 2013

[雑誌論文] Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model.

Yamauchi Haruo 2013

[図書] 1. 田中君枝、佐田政隆 『5. 動脈硬化とアレルギー・炎症

田中君枝、佐田政隆 2013

[学会発表] Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation.

Takeshi Soeki 2013

[雑誌論文] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway.

Yasumasa Ikeda 2012

[雑誌論文] Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate

Kusunose K, Yamada H, Nishio S, Tomita N, Hotchi J, Bando M, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M. 2012

[学会発表] Adventitial angiogenesis plays an important role in the pathogenesis of atherosclerosis.

Masataka Sata 2012

[学会発表] 高脂血症から心臓を守る

佐田政隆 2012

[学会発表] Epicardial adipose tissue plays a role in the pathogenesis of Atherosclerosis.

Masataka Sata 2012

[雑誌論文] Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.

Takeshi Soeki 2012

[雑誌論文] Role of Epicardial Adipose Tissue in Atrial Fibrillation

Takeshi Soeki 2012

[図書] 6. 不安定プラーク破裂に関与する因子は何か?

山口浩司、佐田政隆 2012

[雑誌論文] Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice

Higashikuni Y, Takaoka M, Iwata H, Tanaka K, Hirata Y, Nagai Y, Sata M. 2012

[学会発表] Metabolic Syndrome and Atherosclerosis.

Masataka Sata 2012

[雑誌論文] Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.

Sahara M, Sata M, Morita T, Hirata Y, Nagai R 2012

[雑誌論文] Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects

Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Sakaue H, Nakaya Y, Masuzaki H, Sata M 2012

[図書] 南江堂

島袋充生、佐田政隆 2012

[学会発表] Inflammation in atherosclerosis and adipose tissue.

Masataka Sata 2012

[雑誌論文] Intensive Glucose Lowering in Cardiovascular Risk Management

Shimabukuro, M., Masuzaki, H., Sata, M. 2012

[学会発表] 合成低分子化合物による内因性増殖因子発現誘導と循環器疾患の治療への応用

佐田政隆 2012

[学会発表] 血管機能診断法

佐田政隆 2012

[学会発表] A Pleitropic effect of N-type Ca channel blocker Up-close to the drug effect of CCB.

Masataka Sata 2012

[図書] 2.PPARγ』 動脈硬化症の新しい診断・治療標的(倉林正彦 監修、山岸昌一 編集

田中君枝、佐田政隆 2012

[雑誌論文] A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery

Hirofumi Tomiyama 2012

[学会発表] 動脈硬化と異所性脂肪

佐田政隆 2012

[雑誌論文] Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.

Soeki T, Kitani M, Kusunose K, Yagi S, Taketani Y, Koshiba K, Wakatsuki T, Orino S, Kawano K, Sata M 2012

[雑誌論文] Bicuspid aortic valve endocarditis complicated by perivalvular abscess

Tomoya Hara 2012

[雑誌論文] Effects of statins on cardiorenal syndrome.

Shusuke Yagi 2012

[雑誌論文] Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients.

Ken Yamakawa 2012

[図書] 第II 章 8 トランスレーショナルリサーチに期待する予防医学

田中君枝、佐田政隆 2012

[雑誌論文] Massive splenic infarction due to left ventricular apical thrombus in a patient with giant splenomegaly.

Tomoya Hara 2012

[雑誌論文] Double-chambered right ventricle presenting significant outflow tract obstruction only in the right decubitus position.

Shuji Hayashi 2012

[学会発表] 慢性炎症と心不全

佐田政隆 2012

[雑誌論文] A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.

Hirata Y, Shimabukuro M, Uematsu E, Soeki T, Yamada H, Sakai Y, Nakamura M, Matsumoto K, Igarashi T, Sata M 2012

[図書] 増刊 レジデントノート 循環器診療の疑問、これで納得!(村上裕二 編集) (第2章 7. むずかしくてイヤになる動脈硬化のサイエンス 共著)

添木武 2012

[学会発表] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity.

Takeshi Soeki 2012

[雑誌論文] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M. 2012

[雑誌論文] Intensive Glucose Lowering in Cardiovascular Risk Management

Shimabukuro, M, et al 2012

[雑誌論文] Pre-clinical data on the role of mineralocorticoid receptor antagonists in reversing vascular inflammatio

Yagi S, Sata M. 2011

[雑誌論文] Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.

Yamaguchi K, Wakatsuki T, Niki T, Kusunose K, Koshiba K, Yagi S, Taketani Y, Iwase T, Tomita N, Yamada H, Soeki T, Akaike M, Sata M 2011

[雑誌論文] Removal of pinched-off central venous catheter

Kusunose, K., Wakatsuki, T., Sata, M. 2011

[雑誌論文] Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta

Yagi, T, et al 2011

[雑誌論文] Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient.

Niki T, Wakatsuki T, Yamaguchi K, Kusunose K, Koshiba K, Yagi S, Taketani Y, Iwase T, Tomita N, Yamada H, Soeki T, Akaike M, Sata M 2011

[雑誌論文] Bosentan improves systemic sclerosis-related peripheral circulation insufficiency.

Yagi S, Akaike M, Aihara KI, Iwase T, Sumitomo-Ueda Y, Yoshida S, Matsumoto T, Sata M. 2011

[雑誌論文] Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability

Soeki, T, et al 2011

[雑誌論文] Validation of Longitudinal Peak Systolic Strain by Speckle Tracking Echocardiography With Visual Assessment and Myocardial Perfusion SPECT in Patients With Regional Asynergy

Kusunose K, Yamada H, Nishio S, Mizuguchi Y, Choraku M, Maeda Y, Hosokawa S, Yamazaki N, Tomita N, Niki T, Yamaguchi K, Koshiba K, Soeki T, Wakatsuki T, Akaike M, Sata M 2011

[雑誌論文] Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis

Kusunose K, Yamada H, Tomita N, Nishio S, Niki T, Yamaguchi K, Koshiba K, Yagi S, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Akaike M, Sata M. 2011

[雑誌論文] A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury

Hirata, Y, et al 2011

[図書] 第6 章 病態・治療 Tissue Engineering 技術による血管の再生

黒部裕嗣、佐田政隆 2011

[雑誌論文] Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient

Yamaguchi, K, et al 2011

[学会発表] Elevated concentration of pentraxin 3 is associated with local inflammation in atrial fibrillation

Soeki, T., et al 2011

[学会発表] Pentraxin 3 is a Local Inflammatory Maker in Atrial Fibrillation

Soeki, T., et al 2011

[雑誌論文] Activation of Peroxisome Proliferator-Activated Receptor α in Megakaryocytes Reduces Platelet-Derived Growth Factor-BB in Platelets

Hashizume, S, et al 2011

[学会発表] Atherosclerosis, Angiogenesis and Sex hormones

佐田政隆 2010

[学会発表] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions

M.Sata 2010

[図書] 第5章 異所性脂肪と循環器疾患

平田陽一郎、高岡稔、佐田政隆 2010

[雑誌論文] Crucial role of renin-angiotensin system in the pathogenesis of atheroscle rosis.

M.Sata, et al. 2010

[図書] 心膜疾患、腫瘍 4.心内血栓 循環器疾患 最新の治療

仁木敏之、佐田政隆 2010

[図書] 6 節バルーン傷害モデル

田中君枝、佐田政隆 2010

[学会発表] Vascular injury and repair : beyond the endothelium.

M.Sata 2010