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添木武

徳島大学

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2024年4月29日更新

職名: 特任教授
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電子メール: soeki@clin.med.tokushima-u.ac.jp
学歴: 1992/3: 徳島大学医学部医学科卒業
学位: 学士(医学) (徳島大学) (1992年3月)
職歴・経歴: 〜: 徳島大学講師, 病院 (-2010.12.)
2011/1: 徳島大学講師, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学講師, 大学院医歯薬学研究部 (-2016.3.)
2016/4: 徳島大学准教授, 大学院医歯薬学研究部 (-2020.3.)
2020/4: 徳島大学特任教授, 大学院医歯薬学研究部

専門分野・研究分野: 医学 (Medicine)

研究者総覧で最新データを確認する

2024年4月29日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: 内科学第二 (学部)
循環器コース(3年) (学部)
疾病学2 (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年4月29日更新

専門分野・研究分野: 医学 (Medicine)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

添木武 :
循環器疾患とは (Chapter 2 循環器疾患),
医歯薬出版株式会社, 東京, 2014年5月. 添木武 :
不整脈 (Chapter 2 循環器疾患),
医歯薬出版株式会社, 東京, 2014年5月. 添木武, 佐田政隆 :
循環器領域における新たな検査法の導入,
南江堂, 東京, 2013年6月. 島袋充生, M Dagvasumberel, 石田昌義, 松本幸子, 小塚智沙代, 平良伸一, 屋比久浩市, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 親泊政一, 益埼裕章, 佐田政隆 :
異所性脂肪と2型糖尿病・心臓血管病【特集生活の質(QOL:Quality of life)を高める医療最前線ー難治な病気に光明が見えた!ー】,
徳島医学会, 徳島, 2013年4月.

(要約): There is evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as the metabolic syndrome (MetS). Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in the liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. In addition, ectopic fat deposition play a critical role in the heart components such as (1) circulatory and locally recruited fat, (2) intra-and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is discussed via possible mechanisms including adipocytokine, insulin resistance and lipotoxicity.
(キーワード): Ectopic fat deposition / Diabetes mellitus / Cardiovascular diseases / Obesity / Metabolic syndrome / Lipotoxicity
(徳島大学機関リポジトリ): ● Metadata: 109609
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564287418392064

(徳島大学機関リポジトリ: 109609, CiNii: 1050564287418392064) 添木武, 佐田政隆 :
第2章 7. むずかしくてイヤになる動脈硬化のサイエンス,
株式会社羊土社, 東京, 2012年11月. 齋藤憲, 添木武 :
循環器症候群(第2版)Ⅰ, --- Ⅲ.不整脈(多形性心室頻拍) ---,
日本臨牀社, 大阪, 2007年8月. 福田信夫, 添木武, 武市直樹, 篠原尚典, 由井靖子, 田村禎通, 大木崇 :
弁膜症疾患診断のポイント,
1997年.

論文

N Yamaguchi, Yukina Hirata, Susumu Nishio, Tomonori Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Pulmonary Pressure-flow responses to exercise in heart failure treated with angiotensin receptor neprilysin inhibitor.,
International Journal of Cardiology, Vol.400, 131789, 2024.

(要約): The role of the angiotensin receptor neprilysin inhibitor (ARNI) in cardiac function, particularly its impact on pulmonary circulation, remains underexplored. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (CO) responses as having the potential to assess the disease state. The aim of this study was to assess the effects of ARNI on pulmonary circulation in heart failure. We measured echocardiographic parameters post 6-min walk (6 MW) and compared the changes with baseline and follow-up. Our hypothesis was that pulmonary pressure-flow relationship of the pulmonary circulation obtained by 6 MW stress echocardiography would be improved with treatment. We prospectively enrolled 39 heart failure patients and conducted the 6 MW test indoors. Post-6 MW echocardiography measured echocardiographic variables, and CO was derived from electric cardiometry. Individualized ARNI doses were optimized, with follow-up echocardiographic evaluations after 1 year. Left ventricular (LV) volume were significantly reduced (160.7 ± 49.6 ml vs 136.0 ± 54.3 ml, P < 0.001), and LV ejection fraction was significantly improved (37.6 ± 11.3% vs 44.9 ± 11.5%, P < 0.001). Among the 31 patients who underwent 6 MW stress echocardiographic study at baseline and 1 year later, 6 MW distance increased after treatment (380 m vs 430 m, P = 0.003). The ΔmPAP/ΔCO by 6 MW stress decreased with treatment (6.9 mmHg/L/min vs 2.8 mmHg/L/min, P = 0.002). The left atrial volume index was associated with the response group receiving ARNI treatment for pulmonary circulation. Initiation of ARNI was associated with improvement of left ventricular size and LVEF. Additionally, the 6 MW distance increased and the ΔmPAP/ΔCO was improved to within normal range with treatment.
(徳島大学機関リポジトリ): ● Metadata: 118925
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2024.131789
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246422; ● Search Scopus @ Elsevier (PMID): 38246422; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2024.131789

(徳島大学機関リポジトリ: 118925, DOI: 10.1016/j.ijcard.2024.131789, PubMed: 38246422) S Yamaguchi, M Maeda, K Oba, G Maimaituxun, O Arasaki, Shusuke Yagi, Kenya Kusunose, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Sex differences in the association between epicardial adipose tissue volume and left atrial volume index,
BMC Cardiovascular Disorders, Vol.24, No.1, 46, 2024.

(要約): Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) size have not been elucidated. Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses. In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men. We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.
(キーワード): Humans / Female / Male / Epicardial Adipose Tissue / Sex Characteristics / Heart Atria / Atrial Fibrillation / Atrial Appendage / Adipose Tissue
(徳島大学機関リポジトリ): ● Metadata: 118911
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12872-023-03569-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38218772; ● Search Scopus @ Elsevier (PMID): 38218772; ● Search Scopus @ Elsevier (DOI): 10.1186/s12872-023-03569-1

(徳島大学機関リポジトリ: 118911, DOI: 10.1186/s12872-023-03569-1, PubMed: 38218772) Munkhtsetseg Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Lipoprotein (a) is a risk factor of aortic valve calcification in patients with a risk of atherosclerosis,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 450-456, 2023.

(要約): Aortic valve calcification (AVC), which causes aortic stenosis (AS), is more common in elderly persons. Controlling for conventional risk variables did not, however, reduce the incidence of AS. Thus, residual risk factors of AS should be identified. We enrolled 513 patients who underwent coronary angiography with computed tomography because of suspicion of coronary artery disease (CAD) or ruling out of CAD before aortic valve replacement. Calcium volume was calculated with a commercially available application. Conventional and lipid-related risk factors including serum levels of Lp(a) were evaluated for all patients. Calcium volume and Lp(a) levels were significantly higher in patients who underwent aortic valve replacement than in those who did not. A single regression analysis showed that the calcium volume was positively associated with age and the Lp(a) levels and negatively associated with the estimated glomerular filtration rate. No statistical significance was observed for other risk factors, including oxidized low-density lipoprotein, omega-3 fatty acids levels. The multiple regression analysis revealed that age (P<0.001), female sex (P<0.05), Lp(a) (P<0.01), and hemoglobin A1c (P<0.01) were determinants of the calcium volume. The area under the curve in receiver operating characteristic analysis of Lp(a) for implementation of AVR was 0.65 at an Lp(a) cut-off level of 16 mg/dL. In conclusion, the serum Lp(a) level is a potent risk factor of AVC in patients with high risk of atherosclerosis. J. Med. Invest. 70 : 450-456, August, 2023.
(キーワード): Humans / Female / Aged / Aortic Valve / Lipoprotein(a) / Calcium / Aortic Valve Stenosis / Atherosclerosis / Risk Factors / Coronary Artery Disease
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.450
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940531; ● Search Scopus @ Elsevier (PMID): 37940531; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.450

(DOI: 10.2152/jmi.70.450, PubMed: 37940531) PT Pham, Oyunbileg Bavuu, JR Kim-Kaneyama, XF Lei, T Yamamoto, K Otsuka, Kumiko Suto, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, GN Barber, Masataka Sata and Daiju Fukuda :
Innate Immune System Regulated by Stimulator of Interferon Genes, a Cytosolic DNA Sensor, Regulates Endothelial Function,
Journal of the American Heart Association, Vol.12, No.22, e030084, 2023.

(要約): Background Sterile inflammation caused by metabolic disorders impairs endothelial function; however, the underlying mechanism by which hyperglycemia induces inflammation remains obscure. Recent studies have suggested that stimulator of interferon genes (STING), a key cytosolic DNA sensor in the innate immune system, contributes to the pathogenesis of inflammatory diseases. This study examines the role of the STING in endothelial dysfunction in streptozotocin-induced diabetic mice. Methods and Results Injection of streptozotocin promoted the expression of STING and DNA damage markers in the aorta of wild-type mice. Streptozotocin elevated blood glucose and lipid levels in both wild-type and STING-deficient mice, which showed no statistical differences. Genetic deletion of STING ameliorated endothelial dysfunction as determined by the vascular relaxation in response to acetylcholine (<0.001) and increased endothelial nitric oxide synthase phosphorylation in the aorta (<0.05) in STZ-injected mice. Endothelium-independent vascular response to sodium nitroprusside did not differ. Treatment with a direct STING agonist, cyclic GMP-AMP, or mitochondrial DNA increased inflammatory molecule expression (eg, and ) and decreased endothelial nitric oxide synthase phosphorylation in human umbilical vein endothelial cells, partially through the STING pathway. Cyclic GMP-AMP significantly impaired endothelial function of aortic segments obtained from wild-type mice, which was ameliorated in the presence of C-176, a STING inhibitor, or a neutralizing interferon-β antibody. Furthermore, the administration of C-176 ameliorated endothelial dysfunction in STZ-induced diabetic mice (<0.01). Conclusions The DNA damage response regulated by STING impairs endothelial function. STING signaling may be a potential therapeutic target of endothelial dysfunction caused by hyperglycemia.
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.123.030084
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37947148; ● Search Scopus @ Elsevier (PMID): 37947148; ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.123.030084

(DOI: 10.1161/JAHA.123.030084, PubMed: 37947148) Saya Yasui, Yousuke Kaneko, Hiroki Yamagami, Minae Hosoki, Taiki Hori, Akihiro Tani, Tomoyo Hara, Kiyoe Kurahashi, Takeshi Harada, Shingen Nakamura, Toshiki Otoda, Tomoyuki Yuasa, Hiroyasu Mori, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa, Takeshi Soeki and Ken-ichi Aihara :
Dehydroepiandrosterone Sulfate, an Adrenal Androgen, Is Inversely Associated with Prevalence of Dynapenia in Male Individuals with Type 2 Diabetes.,
Metabolites, Vol.13, No.11, 2023.

(要約): Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. Although skeletal muscle disorders are often found in diabetic people, the clinical significance of DHEAS in skeletal muscle remains unclear. Therefore, we aimed to determine whether DHEAS is associated with the development of skeletal muscle disorders in individuals with type 2 diabetes (T2D). A cross-sectional study was conducted in 361 individuals with T2D. Serum DHEAS levels, skeletal muscle mass index (SMI), handgrip strength (HS), and gait speed (GS) were measured in the participants. Pre-sarcopenia, sarcopenia, and dynapenia were defined according to the definitions of the AWGS 2019 criteria. DHEAS level was positively associated with HS but not with SMI or GS after adjustment of confounding factors. Multiple logistic regression analyses in total subjects showed that DHEAS level had an inverse association with the prevalence of dynapenia but not with the prevalence of pre-sarcopenia or sarcopenia. Furthermore, a significant association between DHEAS level and dynapenia was found in males but not in females. ROC curve analysis indicated that cutoff values of serum DHEAS for risk of dynapenia in males was 92.0 μg/dL. Therefore, in male individuals with T2D who have low serum levels of DHEAS, adequate exercise might be needed to prevent dynapenia.
(徳島大学機関リポジトリ): ● Metadata: 119107
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/metabo13111129
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37999225; ● Search Scopus @ Elsevier (PMID): 37999225; ● Search Scopus @ Elsevier (DOI): 10.3390/metabo13111129

(徳島大学機関リポジトリ: 119107, DOI: 10.3390/metabo13111129, PubMed: 37999225) Yuichiro Okushi, Yoshihito Saijyo, Hirotsugu Yamada, Hiroaki Toba, Robert Zheng, Hiromitsu Seno, Tomonori Takahashi, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose :
Effectiveness of surveillance by echocardiography for Cancer therapeutics-related cardiac dysfunction of patients with breast Cancer,
Journal of Cardiology, Vol.82, No.6, 467-472, 2023.

(要約): Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2023.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37481235; ● Summary page in Scopus @ Elsevier: 2-s2.0-85166962366

(DOI: 10.1016/j.jjcc.2023.07.002, PubMed: 37481235, Elsevier: Scopus) Tomoya Hara, Daiju Fukuda, Byambasuren Ganbaatar, Phuong Tran Pham, Kunduziayi Aini, Arief Rahadian, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice,
Heart and Vessels, Vol.38, No.11, 1386-1394, 2023.

(要約): The Mediterranean diet, which is characterized by high consumption of olive oil, prevents cardiovascular disease. Meanwhile, olive mill wastewater (OMWW), which is obtained as a byproduct during olive oil production, contains various promising bioactive components such as water-soluble polyphenols. Hydroxytyrosol (HT), the major polyphenol in OMWW, has anti-oxidative and anti-inflammatory properties; however, the atheroprotective effects of OMWW and HT remain to be fully understood. Here, we investigated the effect of OMWW and HT on atherogenesis. Male 8-week-old apolipoprotein E-deficient mice were fed a western-type diet supplemented with OMWW (0.30%w/w) or HT (0.02%w/w) for 20 weeks. The control group was fed a non-supplemented diet. OMWW and HT attenuated the development of atherosclerosis in the aortic arch as determined by Sudan IV staining (P < 0.01, respectively) without alteration of body weight, plasma lipid levels, and blood pressure. OMWW and HT also decreased the production of oxidative stress (P < 0.01, respectively) and the expression of NADPH oxidase subunits (e.g., NOX2 and p22phox) and inflammatory molecules (e.g. IL-1β and MCP-1) in the aorta. The results of in vitro experiments demonstrated that HT inhibited the expression of these molecules that were stimulated with LPS in RAW264.7 cells, murine macrophage-like cells. OMWW and HT similarly attenuated atherogenesis. HT is a major component of water-soluble polyphenols in OMWW, and it inhibited inflammatory activation of macrophages. Therefore, our results suggest that the atheroprotective effects of OMWW are at least partially attributable to the anti-inflammatory effects of HT.
(徳島大学機関リポジトリ): ● Metadata: 118456
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-023-02290-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37462755; ● Search Scopus @ Elsevier (PMID): 37462755; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-023-02290-5

(徳島大学機関リポジトリ: 118456, DOI: 10.1007/s00380-023-02290-5, PubMed: 37462755) Tomonori Takahashi, Kenya Kusunose, S Hayashi, Robert Zheng, Natsumi Yamaguchi, Sae Morita, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Isoproterenol loading transesophageal echocardiography in atrial fibrillation,
The International Journal of Cardiovascular Imaging, Vol.39, No.3, 511-518, 2023.

(要約): In patients with sludge or severe spontaneous echo contrast (SEC) in the left atrial appendage (LAA), cases with isoproterenol loading transesophageal echocardiography (ISP-TEE) have been reported to identify the presence of thrombus in the LAA. This study aimed to assess the validity and hemodynamic changes of ISP-TEE in the LAA. We prospectively enrolled patients with atrial fibrillation (AF) who underwent ISP-TEE. The degree of sludge/SEC was categorized as being either absent (grade 0), mild SEC (grade 1), moderate SEC (grade 2), severe SEC or sludge (grade 3). The hemodynamic evaluation was performed by measuring LAA flow velocity, LAA tissue Doppler imaging (LAA-TDI) velocity, and pulmonary vein systolic forward flow velocity (PVS). In total, 35 patients (mean age 71 ± 7 years; 71% male) underwent ISP-TEE. Among 35 patients, 30 patients had grade 3 or 2 SEC, 5 patients had grade 1 SEC. After ISP loading, 23 patients (66% of all patients) showed improved sludge/SEC and one patient was diagnosed with thrombus in the LAA. There were 25 patients with grade 1 SEC, or no SEC (classified as Group1), 10 patients had residual sludge or grade 2 to 3 SEC (classified as Group2) after ISP administration. LAA flow, LAA-TDI, and PVS velocities were significantly higher in group 1 than in group 2 after ISP administration. There was no complication during the examination and after 24 h and 3 months. ISP infusion may be a potential tool to recognize LAA thrombus under the sludge/SEC during TEE in AF.
(キーワード): Humans / Male / Middle Aged / Aged / Female / Atrial Fibrillation / Echocardiography, Transesophageal / Isoproterenol / Sewage / Atrial Appendage / Predictive Value of Tests / Thrombosis
(徳島大学機関リポジトリ): ● Metadata: 118275
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-022-02749-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36357528; ● Search Scopus @ Elsevier (PMID): 36357528; ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-022-02749-y

(徳島大学機関リポジトリ: 118275, DOI: 10.1007/s10554-022-02749-y, PubMed: 36357528) Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Y Tsuruo and Masataka Sata :
Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers,
Circulation Journal, Vol.87, No.2, 329-335, 2023.

(要約): Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (-) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (-) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (-) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS.
(徳島大学機関リポジトリ): ● Metadata: 117602
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-22-0299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244741; ● Search Scopus @ Elsevier (PMID): 36244741; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-22-0299

(徳島大学機関リポジトリ: 117602, DOI: 10.1253/circj.CJ-22-0299, PubMed: 36244741) Tomonori Takahashi, Kenya Kusunose, Robert Zheng, Natsumi Yamaguchi, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease,
Journal of Echocardiography, Vol.20, No.4, 208-215, 2022.

(要約): Some cardiovascular (CV) risk factors, such as hypertension and diabetes mellitus, have been reported to reduce left ventricular (LV) longitudinal strain (LS) even in patients with preserved LV ejection fraction. We hypothesized that multiple CV risk factors might cause changes in myocardial strain. Our study aimed to assess the association between multiple CV risk factors and strain in patients without previous CV disease (CVD). We retrospectively evaluated 137 patients without CVD, who underwent echocardiography at our institution between May 2017 and February 2020. They were divided into four groups based on the number of risk factors (group 0: no risk factor, group 1: one risk factor, group 2: two risk factors, and groups 3: three or four risk factors). Risk factors were hypertension, dyslipidemia, diabetes mellitus, and chronic kidney disease. Absolute values of global LS (GLS) and relative apical LS ratio (RALSR) defined using the equation: average apical LS/(average basal LS + average mid LS) and was used as a marker of strain distribution. Out of 137 patients, group 0 had 35 patients, group 1 had 35 patients, group 2 had 32 patients, and group 3 had 35 patients. GLS was 22.4 ± 2.0%, 21.7 ± 2.1%, 21.3 ± 1.8%, 20.7 ± 2.2%, and RALSR was 0.64 ± 0.06, 0.66 ± 0.06, 0.68 ± 0.08, 0.69 ± 0.07 in groups 0-3, respectively. The one-way ANOVA detected significant differences between groups in GLS (p = 0.005) and RALSR (p = 0.037), respectively. Group 3 had a significantly lower GLS and higher RALSR than group 0 (p < 0.05). In patients without previous CVD, LS decreased especially from the basal segment as the number of cardiovascular risks increased. The segmental LS may be markers of occult LV dysfunction in patients with CV risk factors.
(キーワード): Humans / Cardiovascular Diseases / Retrospective Studies / Risk Factors / Stroke Volume / Ventricular Function, Left / Ventricular Dysfunction, Left / Heart Disease Risk Factors / Hypertension
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12574-022-00576-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35562627; ● Search Scopus @ Elsevier (PMID): 35562627; ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-022-00576-7

(DOI: 10.1007/s12574-022-00576-7, PubMed: 35562627) O Bavuu, Daiju Fukuda, B Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet.,
European Journal of Pharmacology, 175190, 2022.

(要約): Esaxerenone is a novel, non-steroidal selective mineralocorticoid receptor (Csige et al.) blocker. MR activation plays a crucial role in the development of cardiovascular and metabolic diseases. In this study, we investigated the effects of esaxerenone on various metabolic parameters in mice. Esaxerenone (3 mg/kg/day) was orally administered to high-fat diet (HFD)-fed male C57BL/6 mice. Mice fed a normal diet (ND) served as controls. Glucose and insulin tolerance, plasma lipid levels, and transaminase levels were assessed as metabolic parameters. Macrophage accumulation in the adipose tissue was evaluated using histological analysis. 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes were used for in vitro experiments. Gene expression and insulin signaling were examined using quantitative RT-PCR and western blotting, respectively. HFD successfully induced insulin resistance compared with that in ND. Esaxerenone ameliorated insulin resistance (P < 0.05) without altering other metabolic parameters, such as the lipid profile. Esaxerenone administration tended to decrease plasma transaminase levels compared with those in the non-treated group. In the adipose tissue, esaxerenone decreased macrophage accumulation (P < 0.05) and increased the expression levels of adiponectin and PPARγ. Aldosterone significantly decreased the expression levels of PPARγ and adiponectin in 3T3-L1 adipocytes. Furthermore, aldosterone attenuated insulin-induced Akt phosphorylation in 3T3-L1 adipocytes, HepG2 cells, and C2C12 myotubes in a dose-dependent manner (P < 0.01). These effects were ameliorated by pretreatment with esaxerenone. Esaxerenone ameliorated insulin resistance in HFD-fed mice. Reduction of inflammation and improvement in insulin signaling may underlie the beneficial effects of esaxerenone.
(徳島大学機関リポジトリ): ● Metadata: 117375
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2022.175190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35961594; ● Search Scopus @ Elsevier (PMID): 35961594; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2022.175190

(徳島大学機関リポジトリ: 117375, DOI: 10.1016/j.ejphar.2022.175190, PubMed: 35961594) Kenya Kusunose, Hirotsugu Yamada, Y Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical course and decision-making in heart failure by preload stress echocardiography: a preliminary study,
ESC Heart Failure, Vol.9, No.6, 4020-4029, 2022.

(要約): Abnormal left ventricular diastolic response to preload stress can be an early marker of heart failure (HF). The aim of this study was to assess clinical course in patients with HF with preserved ejection fraction (HFpEF) who underwent preload stress echocardiography. In the subgroup analysis, we assessed the prognosis of patients with unstable signs during preload stress classified by treatment strategies. We prospectively conducted preload stress echocardiographic studies between January 2006 and December 2013 in 211 patients with HFpEF. Fifty-eight patients had abnormal diastolic reserve during preload stress (unstable impaired relaxation: unstable IR). Of 58 patients with unstable IR, 19 patients were assigned to additional therapy by increased or additional therapy and 39 patients were assigned to standard therapy. Composite outcomes were prespecified as the primary endpoint of death and hospitalization for deteriorating HF. During a median period of 6.9 years, 19 patients (33%) reached the composite outcome. Unstable group with standard therapy had significantly shorter event-free survival than stable group. Patients with uptitration of therapy had longer event-free survival than those with standard therapy group after adjustment of laboratory data (hazard ratio, 0.20, 95% confidence interval, 0.05-0.90; P = 0.036); the 10 year event-free survival in patients with and without uptitration of therapy was 93% and 51%, respectively (P = 0.023). Patients with unstable sign had significantly shorter event-free survival than patients with stable sign. After additional therapy, the prognosis of patients with unstable signs improved. This technique may impact decision-making for improving their prognosis.
(徳島大学機関リポジトリ): ● Metadata: 118008
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ehf2.14127
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36017722; ● Search Scopus @ Elsevier (PMID): 36017722; ● Search Scopus @ Elsevier (DOI): 10.1002/ehf2.14127

(徳島大学機関リポジトリ: 118008, DOI: 10.1002/ehf2.14127, PubMed: 36017722) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomomi Matsuura, Kazuhisa Matsumoto, Yutaka Kawabata, Muneyuki Kadota, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Drug-coated balloon angioplasty for severe pulmonary vein stenosis resulting from cryoballoon ablation for atrial fibrillation,
Journal of Cardiology Cases, Vol.26, 35-38, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117234
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2022.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85127324683

(徳島大学機関リポジトリ: 117234, DOI: 10.1016/j.jccase.2022.02.009, Elsevier: Scopus) Y Okushi, Kenya Kusunose, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Direct Oral Anticoagulants for Acute Hospital Mortality in Venous Thromboembolism,
American Journal of Cardiovascular Drugs, Vol.22, No.4, 407-416, 2022.

(要約): The choice of direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) is at the physician's discretion; however, it is useful to know the differences in the clinical data of DOACs to help physicians choose. We aimed to compare the mortality associated with the use of rivaroxaban, edoxaban, and apixaban in clinical practice. We identified 38,245 patients with first hospitalization for VTE from the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). We classified patients into three groups by DOAC (rivaroxaban and edoxaban group, rivaroxaban and apixaban group, and edoxaban and apixaban group) and compared the in-hospital mortality and bleeding risk by propensity score (PS) matching in each group. After PS matching, patients with rivaroxaban use had significantly lower total in-hospital mortality (1.2% vs. 2.1%; odds ratio [OR] 0.55, p = 0.012) and in-hospital mortality within 21 days (0.4% vs. 1.0%; OR 0.41, p = 0.020) and 28 days (0.7% vs. 1.3%; OR 0.53, p = 0.042) than patients with apixaban use. In the subanalysis, significant differences were only observed in patients younger than 80 years of age, patients with pulmonary embolism, and patients without heart failure. There was no significant difference in in-hospital mortality in the other groups and in the rate of bleeding events among the three groups. On PS-matched analysis, there was a difference in in-hospital mortality, especially in the rivaroxaban and apixaban group. Identifying the clinical characteristics of patients associated with each DOAC, as well as prognosis, will be useful in determining treatment strategies for VTE.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s40256-021-00514-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34927214; ● Search Scopus @ Elsevier (PMID): 34927214; ● Search Scopus @ Elsevier (DOI): 10.1007/s40256-021-00514-5

(DOI: 10.1007/s40256-021-00514-5, PubMed: 34927214) Kazuhisa Matsumoto, Takeshi Tobiume, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Evaluation of the input site and characteristics of the antegrade fast pathway based on three-dimensional bi-atrial stimulus-ventricle mapping,
Journal of Interventional Cardiac Electrophysiology, Vol.63, No.2, 417-424, 2022.

(要約): Previous studies examined the right atrial (RA) input site of the antegrade fast pathway (AFp) (AFpI). However, the left atrial (LA) input to the atrioventricular (AV) node has not been extensively evaluated. In this study, we created three-dimensional (3-D) bi-atrial stimulus-ventricle (St-V) maps and analyzed the input site and characteristics of the AFp in both the RA and LA. Forty-four patients diagnosed with atrial fibrillation or WPW syndrome were included in this study. Three-dimensional bi-atrial St-V mapping was performed using an electroanatomical mapping system. Sites exhibiting the minimal St-V interval (MinSt-V) were defined as AFpIs and were classified into seven segments, four in the RA (F, S, M, and I) and three in the LA (M1, M2, and M3). By combining the MinSt-V in the RA and LA, the AFpIs were classified into three types: RA, LA, and bi-atrial (BA) types. The clinical and electrophysiological characteristics were compared. AFpIs were most frequently observed at site S in the RA (34%) and M2 in the LA (50%), and the BA type was the most common (57%). AFpIs in the LA were recognized in 75% of the patients. There were no clinical or electrophysiological indicators for predicting AFpI sites. Three-dimensional bi-atrial St-V maps could classify AFpIs in both the RA and LA. AFpIs in the LA were frequently recognized. There were no significant clinical or electrophysiological indicators for predicting AFpI sites, and 3-D bi-atrial St-V mapping was the only method to reveal the precise AFp input site.
(徳島大学機関リポジトリ): ● Metadata: 116382
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10840-021-01026-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34231099; ● Search Scopus @ Elsevier (PMID): 34231099; ● Search Scopus @ Elsevier (DOI): 10.1007/s10840-021-01026-7

(徳島大学機関リポジトリ: 116382, DOI: 10.1007/s10840-021-01026-7, PubMed: 34231099) Shusuke Yagi, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Kenya Kusunose, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Tomohiro Soga, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Clinical clerkship students' preferences and satisfaction regarding online lectures during the COVID-19 pandemic,
BMC Medical Education, Vol.22, No.1, 43, 2022.

(要約): The COVID-19 pandemic has caused an unprecedented disruption in medical education. Students and lecturers had to adapt to online education. The current study aimed to investigate the level of satisfaction and future preference for online lectures among clinical clerkship students and elucidated the factors that affect these outcomes. We selected a sample of 114 medical students undergoing clinical clerkship during the COVID-19 pandemic. We conducted onsite lectures before the pandemic and online lectures after the outbreak. A survey was conducted, and the sample included students and 17 lecturers. The average scores of total satisfaction and future preference related to online lectures were computed. Students' scores on total satisfaction with online lectures and their future preference were higher than those for onsite lectures. Scores on the ease of debating dimension were low and those on accessibility of lectures in online lectures were higher than those in onsite lectures. There was no difference between the two groups in the scores on the comprehensibility and ease of asking questions dimensions. Results of the multiple regression analysis revealed that accessibility determined total satisfaction, and future preference was determined by comprehensibility as well as accessibility. Contrary to students' future preferences, lecturers favored onsite lectures to online ones. Online lectures are an acceptable mode of teaching during the COVID-19 pandemic for students undergoing clinical clerkship. Online lectures are expected to become more pervasive to avoid the spread of COVID-19.
(キーワード): COVID-19 / Clinical Clerkship / Humans / Pandemics / Personal Satisfaction / SARS-CoV-2 / Students, Medical
(徳島大学機関リポジトリ): ● Metadata: 116989
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12909-021-03096-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35042505; ● Summary page in Scopus @ Elsevier: 2-s2.0-85123015852

(徳島大学機関リポジトリ: 116989, DOI: 10.1186/s12909-021-03096-7, PubMed: 35042505, Elsevier: Scopus) Nao Ishii, Kenya Kusunose, A Shono, K Matsumoto, Susumu Nishio, Natsumi Yamaguchi, Yukina Hirata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Radiofrequency Catheter Ablation on Cardiac Reserve Using Preload Stress Echocardiography in Paroxysmal and Persistent Atrial Fibrillation,
The American Journal of Cardiology, Vol.168, 71-77, 2022.

(要約): The effects of catheter ablation on exercise tolerance and quality of life in patients with atrial fibrillation (AF) have been reported. We assessed cardiac function in more detail using the leg positive pressure (LPP) technique and found that contractile reserve is particularly important in relation to exercise tolerance and prognosis. In this study, we used the LPP technique to examine changes in contractile reserve immediately after ablation and 6 months later. We prospectively enrolled patients who underwent catheter ablation for AF at 2 institutes. We performed LPP stress echocardiography 2 to 3 days after (FU-1) and 6 months after (FU-2) ablation to examine changes in cardiac function indexes. The primary end point was improvement in contractile reserve. Ultimately, 109 patients (mean age 67.4 ± 9.6 years; 70% men) underwent 2 sessions of LPP stress echocardiography. The median CHADS-VAS score was 2 (interquartile range 13). From FU-1 to FU-2, the change in the stroke volume index after the LPP maneuver increased in patients with paroxysmal and persistent AF with low CHADS-VAS scores (both p <0.05). Regardless of AF subtype, contractile reserve at FU-2 improved in patients with low CHADS-VAS scores compared with that at FU-1. In contrast, patients with high CHADS-VAS scores had no change. In conclusion, patients with AF with a low CHADS-VAS score had improved contractile reserve after ablation, whereas patients with high scores did not show any improvement. Aggressive interventions in patients with high scores may lead to better management after catheter ablation.
(キーワード): Aged / Atrial Fibrillation / Catheter Ablation / Echocardiography, Stress / Female / Humans / Male / Middle Aged / Predictive Value of Tests / Quality of Life / Risk Assessment / Risk Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 116987
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2021.12.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35063270; ● Search Scopus @ Elsevier (PMID): 35063270; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2021.12.026

(徳島大学機関リポジトリ: 116987, DOI: 10.1016/j.amjcard.2021.12.026, PubMed: 35063270) Kumiko Suto, Daiju Fukuda, Masakazu Shinohara, Byambasuren Ganbaatar, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Ken-Ichi Hirata and Masataka Sata :
Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.,
Journal of Atherosclerosis and Thrombosis, Vol.28, No.12, 1349-1360, 2021.

(要約): Various pathological processes related to diabetes cause endothelial dysfunction. Eicosanoids derived from arachidonic acid (AA) have roles in vascular regulation. Fibrates have recently been shown to attenuate vascular complications in diabetics. Here we examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, on plasma eicosanoid levels and endothelial function in diabetic mice. Diabetes was induced in 7-week-old male wild-type mice by a single injection of streptozotocin (150 mg/kg). Pemafibrate (0.3 mg/kg/day) was administered orally for 3 weeks. Untreated mice received vehicle. Circulating levels of eicosanoids and free fatty acids were measured using both gas and liquid chromatography-mass spectrometry. Endothelium-dependent and endothelium-independent vascular responses to acetylcholine and sodium nitroprusside, respectively, were analyzed. Pemafibrate reduced both triglyceride and non-high-density lipoprotein -cholesterol levels (P<0.01), without affecting body weight. It also decreased circulating levels of AA (P<0.001), thromboxane B (P<0.001), prostaglandin E, leukotriene B (P<0.05), and 5-hydroxyeicosatetraenoic acid (P<0.001), all of which were elevated by the induction of diabetes. In contrast, the plasma levels of 15-deoxy-Δ-prostaglandin J, which declined following diabetes induction, remained unaffected by pemafibrate treatment. In diabetic mice, pemafibrate decreased palmitic acid (PA) and stearic acid concentrations (P<0.05). Diabetes induction impaired endothelial function, whereas pemafibrate ameliorated it (P<0.001). The results of ex vivo experiments indicated that eicosanoids or PA impaired endothelial function. Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.
(徳島大学機関リポジトリ): ● Metadata: 116054
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.61101
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33775978; ● Search Scopus @ Elsevier (PMID): 33775978; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.61101

(徳島大学機関リポジトリ: 116054, DOI: 10.5551/jat.61101, PubMed: 33775978) Kenya Kusunose, Miharu Arase, Robert Zheng, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Overlap Time for Incomplete Relaxation to Predict Cardiac Events in Heart Failure: Incomplete relaxation in heart failure,
Journal of Cardiac Failure, Vol.27, No.11, 1222-1230, 2021.

(要約): The overlap time of transmitral flow can be a novel marker of subclinical left ventricular (LV) dysfunction for predicting adverse events in heart failure (HF). We aimed to 1) investigate the role of overlap time of E-A wave in association with clinical parameters, and 2) evaluate whether the overlap time could add prognostic information with respect to other conventional clinical prognosticators in HF. We prospectively evaluated 153 patients hospitalized with HF (mean age 68±15 years; 63% male). The primary endpoint was readmission following HF and cardiac death. During a median period of 25 months, 43 patients were either readmitted or died. Overlap time appeared to be associated with worse outcomes. After adjustment for readmission score and ratio of diastolic filling period and cardiac cycle length in a Cox proportional-hazards model, overlap time was associated with event free survival, independent of elevated left atrial pressure (LAP) based on guidelines. When overlap time was added to the model based on clinical variables and elevated LAP, the C-statistic significantly improves from 0.70 (95% CI: 0.63-0.77) to 0.77 (95% CI: 0.69-0.83, compared P=0.035). This preliminary study suggested that prolonged overlap time may have potential for predicting readmission and cardiac mortality risk assessment in HF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2021.05.018
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34129950; ● Search Scopus @ Elsevier (PMID): 34129950; ● Search Scopus @ Elsevier (DOI): 10.1016/j.cardfail.2021.05.018

(DOI: 10.1016/j.cardfail.2021.05.018, PubMed: 34129950) Robert Zheng, Kenya Kusunose, Y Okushi, Y Okayama, M Nakai, Y Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cancer on short-term in-hospital mortality after primary acute myocardial infarction,
Open Heart, Vol.8, No.2, e00186, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116972
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2021-001860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34810277; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120377378

(徳島大学機関リポジトリ: 116972, DOI: 10.1136/openhrt-2021-001860, PubMed: 34810277, Elsevier: Scopus) Kenya Kusunose, Hironori Takahashi, Susumu Nishio, Yukina Hirata, Robert Zheng, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Masataka Sata :
Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source,
Journal of Cardiology, Vol.78, No.5, 355-361, 2021.

(要約): In patients with embolic stroke of undetermined source (ESUS), paroxysmal atrial fibrillation (AF) is often diagnosed, however, the risk of paroxysmal AF in ESUS has not been well described. Several studies have suggested a linkage between left atrial (LA) functional parameters and risk of AF in stroke patients. The aim of this study was to assess the role of LA functional parameters as predictors of latent paroxysmal AF in ESUS on admission. Between January 2015 and December 2019, consecutive stroke patients with suspected ESUS at admission were prospectively included in this study. They were under hospital electrocardiographic monitoring for detection of new-onset AF. Various echocardiographic parameters including left atrial strain were assessed for association with new-onset AF. We gathered 1082 consecutive patients with ischemic stroke. After exclusions, 121 patients with suspected ESUS at admission formed the study cohort. New-onset AF was detected in 46 (38%) patients during hospital electrocardiographic monitoring (median follow-up: 18 days). LA pump and reservoir strains were significantly and independently associated with new-onset AF. Receiver operating characteristic analysis for the association with new-onset AF showed that the areas under the curve (AUCs) of clinical parameters plus one of each strain (LA pump strain: AUC: 0.86±0.04 and LA reservoir strain: AUC: 0.76±0.05) models were significantly better than plus LA volume index (AUC: 0.68±0.04, compared p-values <0.05). LA strain was significantly associated with new development of AF. Patients with impaired LA function at admission should be carefully monitored to find AF.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2021.05.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34119401; ● Search Scopus @ Elsevier (PMID): 34119401; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2021.05.005

(DOI: 10.1016/j.jjcc.2021.05.005, PubMed: 34119401) Kenya Kusunose, Yuichiro Okushi, Yoshihiro Okayama, Robert Zheng, Michikazu Nakai, Yoko Sumita, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Use of Echocardiography and Heart Failure In-Hospital Mortality from Registry Data in Japan.,
Journal of Cardiovascular Development and Disease, Vol.8, No.10, 124, 2021.

(要約): Echocardiography requires a high degree of skill on the part of the examiner, and the skill may be more improved in larger volume centers. This study investigated trends and outcomes associated with the use and volume of echocardiographic exams from a real-world registry database of heart failure (HF) hospitalizations. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). A first analysis was performed to assess the trend of echocardiographic examinations between 2012 and 2016. A secondary analysis was performed to assess whether echocardiographic use was associated with in-hospital mortality in 2015. During this period, the use of echocardiography grew at an average annual rate of 6%. Patients with echocardiography had declining rates of hospital mortality, and these trends were associated with high hospitalization costs. In the 2015 sample, a total of 52,832 echocardiograms were examined, corresponding to 65.6% of all HF hospital admissions for that year. We found that the use and volume of echocardiography exams were associated with significantly lower odds of all-cause hospital mortality in heart failure (adjusted odds ratio (OR): 0.48 for use of echocardiography and 0.78 for the third tertile; both < 0.001). The use of echocardiography was associated with decreased odds of hospital mortality in HF. The volumes of echocardiographic examinations were also associated with hospital mortality.
(徳島大学機関リポジトリ): ● Metadata: 117323
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcdd8100124
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34677193; ● Summary page in Scopus @ Elsevier: 2-s2.0-85116636823

(徳島大学機関リポジトリ: 117323, DOI: 10.3390/jcdd8100124, PubMed: 34677193, Elsevier: Scopus) Shusuke Yagi, T Takahashi, K Murakami, M Azuma, M Sugano, R Miyamoto, M Niki, Hirotsugu Yamada, Yutaka Kawabata, Tani Akihiro, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Tomomi Matsuura, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, H Hata and Masataka Sata :
Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant Staphylococcus aureus,
Internal Medicine, Vol.60, No.20, 3251-3255, 2021.

(徳島大学機関リポジトリ): ● Metadata: 118014
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.6902-20
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33867390; ● Search Scopus @ Elsevier (PMID): 33867390; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.6902-20

(徳島大学機関リポジトリ: 118014, DOI: 10.2169/internalmedicine.6902-20, PubMed: 33867390) Yuta Torii, Kenya Kusunose, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Atrial Strain Associated with Functional Recovery in Patients Receiving Optimal Treatment for Heart Failure,
Journal of the American Society of Echocardiography, Vol.34, No.9, 966-975, 2021.

(要約): Heart failure with recovered ejection fraction (HFrecEF) has been reported in several previous studies to have a better prognosis than heart failure with reduced ejection fraction (HFrEF). However, the factors associated with HFrecEF have not been identified. The aim of this study was to test the hypothesis that left atrial (LA) strain could help identify patients with recovered ejection fraction (EF) among those with heart failure (HF) with low EF on admission. One hundred consecutive patients hospitalized for the first time for new-onset HF were enrolled. Patients were clinically diagnosed with HFrEF on admission (left ventricular EF < 40%) and received optimal treatment for HF. Twenty-eight patients improved to HFrecEF during 6 months of follow-up. Regarding clinical background, there were significantly more women and a lower rate of atrial fibrillation in the HFrecEF group than in the HFrEF group. In a multivariate logistic regression analysis, LA strain was an independent predictor of HFrecEF, even after adjustment for gender and left ventricular EF (odds ratio: 4.06; 95% CI: 2.04-8.07; P < .001). A cutoff value of 10.8% for LA strain showed high sensitivity (96%) and specificity (82%) in identifying HFrecEF in patients with HF presenting with low EF on admission. During a follow-up period of 24 ± 13 months, 31 patients (31%) had cardiovascular death or readmission for HF. Patients with reduced LA strain (<10.8%) had significantly shorter event-free survival than those with preserved LA strain (P = .02). LA strain is a useful indicator for predicting HFrecEF and should be considered as a routine measurement in patients with HFrEF on admission.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2021.03.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33852960; ● Search Scopus @ Elsevier (PMID): 33852960; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2021.03.016

(DOI: 10.1016/j.echo.2021.03.016, PubMed: 33852960) Tomomi Matsuura, Takeshi Soeki, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, Tomoya Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation,
Circulation Journal, Vol.85, No.8, 1383-1391, 2021.

(要約): Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling contributes to AF arrhythmogenesis and whether rivaroxaban ameliorates atrial inflammation and prevents AF.Methods and Results:In Study 1, PAR2 deficient (PAR2-/-) and wild-type mice were infused with angiotensin II (Ang II) or a vehicle via an osmotic minipump for 2 weeks. In Study 2, spontaneously hypertensive rats (SHRs) were treated with rivaroxaban, warfarin, or vehicle for 2 weeks after 8 h of right atrial rapid pacing. The AF inducibility and atrial remodeling in both studies were examined. Ang II-treated PAR2-/- mice had a lower incidence of AF and less mRNA expression of collagen1 and collagen3 in the atrium compared to wild-type mice treated with Ang II. Rivaroxaban significantly reduced AF inducibility compared with warfarin or vehicle. In SHRs treated with a vehicle, rapid atrial pacing promoted gene expression of inflammatory and fibrosis-related biomarkers in the atrium. Rivaroxaban, but not warfarin, significantly reduced expression levels of these genes. The FXa-PAR2 signaling pathway might contribute to AF arrhythmogenesis associated with atrial inflammation. A direct FXa inhibitor, rivaroxaban, could prevent atrial inflammation and reduce AF inducibility, probably by inhibiting the pro-inflammatory activation.
(徳島大学機関リポジトリ): ● Metadata: 116065
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-20-1006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33746155; ● Summary page in Scopus @ Elsevier: 2-s2.0-85111576585

(徳島大学機関リポジトリ: 116065, DOI: 10.1253/circj.CJ-20-1006, PubMed: 33746155, Elsevier: Scopus) Pham Tran Phuong, Daiju Fukuda, Sachiko Nishimoto, JR Kim-Kaneyama, XF Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N Barber and Masataka Sata :
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases,
European Heart Journal, Vol.42, No.42, 4336-4348, 2021.

(要約): Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through the recognition by DNA sensors. Here, we investigated the role of stimulator of interferon genes (STING), a cytosolic DNA sensor, in atherogenesis. Apolipoprotein E-deficient (Apoe-/-) mice fed a western-type diet (WTD), a hypercholesterolaemic mouse model, showed higher STING expression and markers for DNA damage such as γH2AX, p53, and single-stranded DNA (ssDNA) accumulation in macrophages in the aorta compared with wild-type (WT) mice. The level of cGAMP, a STING agonist, in the aorta was higher in Apoe-/- mice. Genetic deletion of Sting in Apoe-/- mice reduced atherosclerotic lesions in the aortic arch, lipid, and macrophage accumulation in plaques, and inflammatory molecule expression in the aorta compared with the control. Pharmacological blockade of STING using a specific inhibitor, C-176, ameliorated atherogenesis in Apoe-/- mice. In contrast, bone marrow-specific STING expression in Apoe-/- mice stimulated atherogenesis. Expression or deletion of STING did not affect metabolic parameters and blood pressure. In vitro studies revealed that STING activation by cGAMP or mitochondrial DNA accelerated inflammatory molecule expression (e.g. TNF-α or IFN-β) in mouse and human macrophages. Activation of nuclear factor-κB and TANK binding kinase 1 was involved in STING-associated vascular inflammation and macrophage activation. Furthermore, human atherosclerotic lesions in the carotid arteries expressed STING and cGAMP. Stimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34226923; ● Summary page in Scopus @ Elsevier: 2-s2.0-85120384111

(DOI: 10.1093/eurheartj/ehab249, PubMed: 34226923, Elsevier: Scopus) B Ganbaatar, Daiju Fukuda, M Shinohara, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, KI Hirata and Masataka Sata :
Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice,
Journal of Atherosclerosis and Thrombosis, Vol.28, No.6, 630-642, 2021.

(要約): The bioactive lipid, sphingosine-1-phosphate (S1P), has various roles in the physiology and pathophysiology of many diseases. There are five S1P receptors; however, the role of each S1P receptor in atherogenesis is still obscure. Here we investigated the contribution of S1P receptor 2 (S1P2) to atherogenesis by using a specific S1P2 antagonist, ONO-5430514, in apolipoprotein E-deficient (Apoe) mice. Apoe mice fed with a western-type diet (WTD) received ONO-5430514 (30 mg/kg/day) or vehicle. To examine the effect on atherogenesis, Sudan IV staining, histological analysis, qPCR, and vascular reactivity assay was performed. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments. WTD-fed Apoe mice had significantly higher S1P2 expression in the aorta compared with wild-type mice. S1P2 antagonist treatment for 20 weeks reduced atherosclerotic lesion development (p<0.05). S1P2 antagonist treatment for 8 weeks ameliorated endothelial dysfunction (p<0.05) accompanied with significant reduction of lipid deposition, macrophage accumulation, and inflammatory molecule expression in the aorta compared with vehicle. S1P2 antagonist attenuated the phosphorylation of JNK in the abdominal aorta compared with vehicle (p<0.05). In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 p<0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (p<0.01). S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (p<0.05). Our results suggested that an S1P2 antagonist attenuates endothelial dysfunction and prevents atherogenesis. S1P2, which promotes inflammatory activation of endothelial cells, might be a therapeutic target for atherosclerosis.
(徳島大学機関リポジトリ): ● Metadata: 116449
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.54916
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32879149; ● Search Scopus @ Elsevier (PMID): 32879149; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.54916

(徳島大学機関リポジトリ: 116449, DOI: 10.5551/jat.54916, PubMed: 32879149) Y Okushi, Kenya Kusunose, Y Okayama, Robert Zheng, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data,
Journal of the American Heart Association, Vol.10, No.11, e019373, 2021.

(要約): Background The prognosis of patients with cancer-venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate the clinical characteristics and outcomes of patients with cancer-associated VTE, compared with a matched cohort without cancer using real-world registry data of VTE. Methods and Results This study was based on the Diagnosis Procedure Combination database in the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination). Of 5 106 151 total patients included in JROAD-DPC, we identified 49 580 patients who were first hospitalized with VTE from April 2012 to March 2017. Propensity score was estimated with a logistic regression model, with cancer as the dependent variable and 18 clinically relevant covariates. After propensity matching, there were 25 148 patients with VTE with or without cancer. On propensity score-matched analysis with 25 148 patients with VTE, patients with cancer had higher total in-hospital mortality within 7 days (1.3% versus 1.1%, odds ratio [OR], 1.66; 95% CI, 1.31-2.11; <0.0001), 14 days (2.5% versus 1.5%, OR, 2.07; 95% CI, 1.72-2.49; <0.0001), and 30 days (4.8% versus 2.0%, OR, 2.85; 95% CI, 2.45-3.31; <0.0001). On analysis for each type of cancer, in-hospital mortality in 11 types of cancer was significantly high, especially pancreas (OR, 12.96; 95% CI, 6.41-26.20), biliary tract (OR, 8.67; 95% CI, 3.00-25.03), and liver (OR, 7.31; 95% CI, 3.05-17.50). Conclusions Patients with cancer had a higher in-hospital acute mortality for VTE than those without cancer, especially in pancreatic, biliary tract, and liver cancers.
(徳島大学機関リポジトリ): ● Metadata: 116140
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.120.019373
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34027673; ● Search Scopus @ Elsevier (PMID): 34027673; ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.120.019373

(徳島大学機関リポジトリ: 116140, DOI: 10.1161/JAHA.120.019373, PubMed: 34027673) Miharu Arase, Kenya Kusunose, N Yamaguchi, Yukina Hirata, Susumu Nishio, Y Okushi, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis.,
Open Heart, Vol.8, No.1, e001559, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116465
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/openhrt-2020-001559
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1136/openhrt-2020-001559

(徳島大学機関リポジトリ: 116465, DOI: 10.1136/openhrt-2020-001559) Kenya Kusunose, Y Okushi, Y Okayama, Robert Zheng, M Abe, M Nakai, Y Sumita, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals.,
Nutrients, Vol.13, No.2, 335, 2021.

(要約): A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates. On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, < 0.001) and in-hospital mortality within 7 days and 30 days (0.9 vs. 2.5%, OR, 0.34, and 3.8 vs. 6.5%, OR: 0.56, both < 0.001). In the sub-group analysis, mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and β-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials.
(徳島大学機関リポジトリ): ● Metadata: 116464
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/nu13020335
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33498709; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099832739

(徳島大学機関リポジトリ: 116464, DOI: 10.3390/nu13020335, PubMed: 33498709, Elsevier: Scopus) Gulinu Maimaituxun, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Nao Yamada, Takeshi Soeki, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction,
Frontiers in Cardiovascular Medicine, Vol.7, 607825, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fcvm.2020.607825
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33521062; ● Search Scopus @ Elsevier (PMID): 33521062; ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2020.607825

(DOI: 10.3389/fcvm.2020.607825, PubMed: 33521062) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 189-191, 2021.

(要約): The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116019
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.189
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994469; ● Search Scopus @ Elsevier (PMID): 33994469; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.189

(徳島大学機関リポジトリ: 116019, DOI: 10.2152/jmi.68.189, PubMed: 33994469) Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, M Kitani, K Kawano, Y Taketani and Masataka Sata :
Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients,
International Journal of Hypertension, 6653851, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115937
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2020/6653851
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33489354; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098701678

(徳島大学機関リポジトリ: 115937, DOI: 10.1155/2020/6653851, PubMed: 33489354, Elsevier: Scopus) Takeshi Tobiume, R Kato, Tomomi Matsuura, Kazuhisa Matsumoto, M Hara, N Takamori, Y Taketani, K Okwa, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki, Masataka Sata and K Matsumoto :
Antegrade slow pathway mapping of typical atrioventricular nodal reentrant tachycardia based on direct slow pathway capture,
Journal of Arrhythmia, Vol.37, No.1, 128-139, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116343
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/joa3.12484
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33664895; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099515348

(徳島大学機関リポジトリ: 116343, DOI: 10.1002/joa3.12484, PubMed: 33664895, Elsevier: Scopus) Kenya Kusunose, nao Yamada, Hirotsugu Yamada, Susumu Nishio, Yoshihito Saijoh, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association between Right Ventricular Contractile Function and Cardiac Events in Isolated Post-capillary and Combined Pre- and Post-capillary Pulmonary Hypertension,
Journal of Cardiac Failure, Vol.26, No.1, 43-51, 2020.

(要約): Recent studies have shown that patients with combined pre- and postcapillary pulmonary hypertension (CpcPH) had worse outcomes than those with isolated postcapillary pulmonary hypertension (IpcPH). However, the prognostic factors including right ventricular (RV) function have not been well documented. The aim of this study was to assess the differentiation of PH phenotypes, using echocardiography, and the association between RV longitudinal strain and cardiac events. We prospectively recruited consecutive patients who had undergone right heart catheterization. The primary endpoint was cardiovascular death or readmission due to heart failure. We included 137 patients with Group 2 PH. A RV longitudinal strain of 17% was sensitive (85%) and specific (70%) to determine the CpcPH. During a median period of 31 months, 43 patients experienced the primary endpoint during follow-up. In a multivariate analysis, RV longitudinal strain was associated with the primary endpoint in both CpcPH and IpcPH (HR: 0.84, P = 0.003; HR: 0.86, P = 0.001). Lower RV longitudinal strain was independently associated with worse outcomes in CpcPH and IpcPH. RV longitudinal strain may play a prognostic role in PH phenotypes.
(徳島大学機関リポジトリ): ● Metadata: 114190
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cardfail.2019.08.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31487533; ● Summary page in Scopus @ Elsevier: 2-s2.0-85072539026

(徳島大学機関リポジトリ: 114190, DOI: 10.1016/j.cardfail.2019.08.021, PubMed: 31487533, Elsevier: Scopus) Yuta Torii, Kenya Kusunose, Robert Zheng, Hirotsugu Yamada, Rie Amano, Rikizo Matsumoto, Yukina Hirata, Susumu Nishio, Nao Yamada, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Yoshihiro Okayama and Masataka Sata :
Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants,
International Heart Journal, Vol.61, No.4, 787-794, 2020.

(要約): Advanced age, obesity, and muscle weakness are independent factors in the onset of deep vein thrombosis (DVT). Recently, an association between sarcopenia and DVT has been reported. We hypothesized that sarcopenia related factors, observed by ultrasonography, are associated with the regression effect on the thrombus following anticoagulation therapy. The present study focused on gastrocnemius muscle (GCM) thickness and the GCM's internal echogenic brightness. We examined the association with DVT regression following direct oral anticoagulants (DOACs) treatment.The prospective cohort study period was between October 2017 and August 2018. We enrolled 46 patients diagnosed with DVT by ultrasonography, who were aged >60 years old and treated with DOACs. Sarcopenia was evaluated using the Asian Working Group for Sarcopenia flowchart. The average DOACs treatment period was 94 days, and 29 patients exhibited thrombus regression. On univariate logistic regression analysis, sarcopenia, average GCM diameter index, and gastrocnemius integrated backscatter index were significantly associated with thrombus regression. In a multivariate model, only the average GCM diameter index correlated with thrombus regression.The average GCM diameter index is associated with DVT regression treated with DOACs. Considering the GCM diameter during DVT treatment can be a marker to make a decision for the treatment of DVT.
(キーワード): Aged / Aged, 80 and over / Factor Xa Inhibitors / 女性 (female) / Humans / 男性 (male) / Middle Aged / Muscle, Skeletal / Prospective Studies / Sarcopenia / Ultrasonography / Venous Thrombosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.20-032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32684602; ● Summary page in Scopus @ Elsevier: 2-s2.0-85088879684

(DOI: 10.1536/ihj.20-032, PubMed: 32684602, Elsevier: Scopus) Kenya Kusunose, M Fujiwara, Hirotsugu Yamada, Susumu Nishio, Y Saijo, N Yamada, Yukina Hirata, Yuta Torii, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Deterioration of Biventricular Strain Is an Early Marker of Cardiac Involvement in Confirmed Sarcoidosis,
European Heart Journal Cardiovascular Imaging, Vol.21, No.7, 796-804, 2020.

(要約): Risk assessment of developing cardiac involvement in systemic sarcoidosis can be challenging because of limited data. Recently, attention has been given to left ventricular and right ventricular (LV and RV) involvement in cardiac sarcoidosis (CS) and its prevalence, relevance, and prognostic value. The aim of this study was to assess the role of biventricular strain to predict prognosis in confirmed sarcoidosis patients. LV and RV longitudinal strains (LSs) were evaluated by 2D speckle tracking in 139 consecutive confirmed sarcoidosis patients without other pre-existing structural heart diseases, and 52 age- and gender-matched control subjects. The primary endpoint was CS-related events (cardiac death or development of cardiac involvement). Sarcoidosis without cardiac involvement had significantly lower LV and RV free wall LS compared with control subjects. Basal LS had a higher area under the curve for differentiation of sarcoidosis in patients without cardiac involvement compared to control (cut-off value: -18% with 89% sensitivity and 69% specificity). During a median period of 50 months, the occurrence of CS-related events was observed in 20 patients. In a multivariate analysis, basal LV LS and RV free wall LS were associated with the events [hazard ratio (HR) 0.72, P < 0.001 and HR: 0.83, P = 0.006, respectively]. Patients with impaired biventricular function had significantly shorter event-free survival than those with preserved biventricular function (P < 0.001). Deterioration of biventricular strain was associated with CS-related events. This information might be useful for clinical evaluation and follow-up in sarcoidosis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/jez235
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31566217; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086792785

(DOI: 10.1093/ehjci/jez235, PubMed: 31566217, Elsevier: Scopus) Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Yoshihiro Tsuruo and Masataka Sata :
Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers,
Circulation Journal, Vol.84, No.5, 769-775, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116640
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32281556; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083919450

(徳島大学機関リポジトリ: 116640, DOI: 10.1253/circj.CJ-19-0914, PubMed: 32281556, Elsevier: Scopus) B Ganbaatar, Daiju Fukuda, M Shinohara, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, KI Hirata and Masataka Sata :
Empagliflozin Ameliorates Endothelial Dysfunction and Suppresses Atherogenesis in Diabetic Apolipoprotein E-deficient Mice,
European Journal of Pharmacology, Vol.15, No.875, 173040, 2020.

(要約): Recent studies reported cardioprotective effects of sodium glucose co-transporter 2 (SGLT2) inhibitors; however, the underlying mechanisms are still obscure. Here, we investigated whether empagliflozin attenuates atherogenesis and endothelial dysfunction in diabetic apolipoprotein E-deficient (ApoE) mice. Male streptozotocin (STZ) - induced diabetic ApoE mice were treated with empagliflozin for 12 or 8 weeks. Empagliflozin lowered blood glucose (P < 0.001) and lipid levels in diabetic ApoE mice. Empagliflozin treatment for 12 weeks significantly decreased atherosclerotic lesion size in the aortic arch (P < 0.01) along with reduction of lipid deposition (P < 0.05), macrophage accumulation (P < 0.001), and inflammatory molecule expression in plaques compared with the untreated group. Empagliflozin treatment for 8 weeks significantly ameliorated diabetes-induced endothelial dysfunction as determined by the vascular response to acetylcholine (P < 0.001). Empagliflozin reduced RNA expression of a macrophage marker, CD68, and inflammatory molecules such as MCP-1 (P < 0.05) and NADPH oxidase subunits in the aorta compared with the untreated group. Empagliflozin also reduced plasma levels of vasoconstrictive eicosanoids, prostaglandin E and thromboxane B (P < 0.001), which were elevated in diabetic condition. Furthermore, empagliflozin attenuated RNA expression of inflammatory molecules in perivascular adipose tissue (PVAT), suggesting the reduction of inflammation in PVAT. In in vitro studies, methylglyoxal (MGO), a precursor of AGEs, significantly increased the expression of inflammatory molecules such as MCP-1 and TNF-α in a murine macrophage cell line, RAW264.7. Our results indicated that empagliflozin attenuated endothelial dysfunction and atherogenesis in diabetic ApoE mice. Reduction of vasoconstrictive eicosanoids and inflammation in the vasculature and PVAT may have a role as underlying mechanisms at least partially.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2020.173040
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32114052; ● Summary page in Scopus @ Elsevier: 2-s2.0-85080985939

(DOI: 10.1016/j.ejphar.2020.173040, PubMed: 32114052, Elsevier: Scopus) Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice,
Journal of Atherosclerosis and Thrombosis, Vol.27, No.11, 1141-1151, 2020.

(要約): Recent studies have demonstrated that selective sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular events, although their mechanism remains obscure. We examined the effect of canagliflozin, an SGLT2i, on atherogenesis and investigated its underlying mechanism. Canagliflozin (30 mg/kg/day) was administered by gavage to streptozotocin-induced diabetic apolipoprotein E-deficient (ApoE) mice. Sudan IV staining was performed at the aortic arch. Immunostaining, quantitative RT-PCR, and vascular reactivity assay were performed using the aorta. In vitro experiments using human umbilical vein endothelial cells (HUVECs) were also performed. Canagliflozin decreased blood glucose (P<0.001) and total cholesterol (P<0.05) levels. Sudan IV staining showed that 12-week canagliflozin treatment decreased atherosclerotic lesions (P<0.05). Further, 8-week canagliflozin treatment ameliorated endothelial dysfunction, as determined by acetylcholine-induced vasodilation (P<0.05), and significantly reduced the expressions of inflammatory molecules such as ICAM-1 and VCAM-1 in the aorta at the RNA and protein levels. Canagliflozin also reduced the expressions of NADPH oxidase subunits such as NOX2 and p22phox in the aorta and reduced urinary excretion of 8-OHdG, suggesting a reduction in oxidative stress. Methylglyoxal, a precursor of advanced glycation end products, increased the expressions of ICAM-1 and p22phox in HUVECs (P<0.05, both). Methylglyoxal also decreased the phosphorylation of eNOS and Akt but increased the phosphorylation of eNOS and p38 MAPK in HUVECs. Canagliflozin prevents endothelial dysfunction and atherogenesis in diabetic ApoE mice. Anti-inflammatory and antioxidative potential due to reduced glucose toxicity to endothelial cells might be its underlying mechanisms.
(徳島大学機関リポジトリ): ● Metadata: 115926
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.52100
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32101837; ● CiNii @ 国立情報学研究所 (CRID): 1390286426514028416; ● Search Scopus @ Elsevier (PMID): 32101837; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.52100

(徳島大学機関リポジトリ: 115926, DOI: 10.5551/jat.52100, PubMed: 32101837, CiNii: 1390286426514028416) Maimaituxun Gulinu, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirata Yukina, Nishio Susumu, Takeshi Soeki, Masuzaki Hiroaki, Masataka Sata and Michio Shimabukuro :
Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction,
Circulation Journal, Vol.84, No.2, 203-216, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0793
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31956209; ● Summary page in Scopus @ Elsevier: 2-s2.0-85079208017

(DOI: 10.1253/circj.CJ-19-0793, PubMed: 31956209, Elsevier: Scopus) Arief Rahadian, Daiju Fukuda, HM Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Thrombin inhibition by dabigatran attenuates endothelial dysfunction in diabetic mice,
Vascular Pharmacology, Vol.124, 106632, 2020.

(要約): Diabetic patients have coagulation abnormalities, in which thrombin plays a key role. Whereas accumulating evidence suggests that it also contributes to the development of vascular dysfunction through the activation of protease-activated receptors (PARs). Here we investigated whether the blockade of thrombin attenuates endothelial dysfunction in diabetic mice. Induction of diabetes by streptozotocin (STZ) increased the expression of PAR1, PAR3, and PAR4 in the aorta. STZ-induced diabetic mice showed impairment of endothelial function, while the administration of dabigatran etexilate, a direct thrombin inhibitor, significantly attenuated endothelial dysfunction in diabetic mice with no alteration of metabolic parameters including blood glucose level. Dabigatran did not affect endothelium-independent vasodilation. Dabigatran decreased the expression of inflammatory molecules (e.g., MCP-1 and ICAM-1) in the aorta of diabetic mice. Thrombin increased the expression of these inflammatory molecules and the phosphorylation of IκBα, and decreased the phosphorylation of eNOS in human umbilical endothelial cells (HUVEC). Thrombin significantly impaired the endothelium-dependent vascular response of aortic rings obtained from wild-type mice. Inhibition of NF-κB attenuated thrombin-induced inflammatory molecule expression in HUVEC and ameliorated thrombin-induced endothelial dysfunction in aortic rings. Dabigatran attenuated the development of diabetes-induced endothelial dysfunction. Thrombin signaling may serve as a potential therapeutic target in diabetic condition.
(徳島大学機関リポジトリ): ● Metadata: 114211
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.vph.2019.106632
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31759113; ● Search Scopus @ Elsevier (PMID): 31759113; ● Search Scopus @ Elsevier (DOI): 10.1016/j.vph.2019.106632

(徳島大学機関リポジトリ: 114211, DOI: 10.1016/j.vph.2019.106632, PubMed: 31759113) K Aini, Daiju Fukuda, K Tanaka, Y Higashikuni, Yukina Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice,
International Heart Journal, Vol.60, No.6, 1421-1429, 2019.

(要約): Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel antidiabetic agents with possible vascular protection effects. Endothelial dysfunction is an initiation step in atherogenesis. The purpose of this study was to investigate whether vildagliptin (Vilda) attenuates the development of endothelial dysfunction and atherosclerotic lesions in nondiabetic apolipoprotein E-deficient (ApoE) mice. Eight-week-old nondiabetic ApoE mice fed a Western-type diet received Vilda (50 mg/kg/day) for 20 weeks or 8 weeks. After 20 weeks of treatment, Vilda administration reduced atherogenesis in the aortic arch as determined by en face Sudan IV staining compared with the vehicle group (P < 0.05). Vilda also reduced lipid accumulation (P < 0.05) and vascular cell adhesion molecule-1 (VCAM-1) expression (P < 0.05) and tended to decrease macrophage infiltration (P = 0.05) into atherosclerotic plaques compared with vehicle. After 8 weeks of treatment, endothelium-dependent vascular reactivity was examined. Vilda administration significantly attenuated the impairment of endothelial function in nondiabetic ApoE mice compared with the vehicle group (P < 0.05). Vilda treatment did not alter metabolic parameters, including blood glucose level, in both study protocols. To investigate the mechanism, aortic segments obtained from wild-type mice were incubated with exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) analog, in the presence or absence of lipopolysaccharide (LPS). Ex-4 attenuated the impairment of endothelium-dependent vasodilation induced by LPS (P < 0.01). Furthermore, Ex-4 promoted phosphorylation of eNOS at Ser1177 which was decreased by LPS in human umbilical endothelial cells (P < 0.05). Vilda inhibited the development of endothelial dysfunction and prevented atherogenesis in nondiabetic ApoE mice. Our results suggested that GLP-1-dependent amelioration of endothelial dysfunction is associated with the atheroprotective effects of Vilda.
(キーワード): Animals / Apolipoproteins E / Atherosclerosis / Cell Culture Techniques / Dipeptidyl-Peptidase IV Inhibitors / Disease Models, Animal / Endothelial Cells / Endothelium, Vascular / Mice / Mice, Inbred C57BL / Vascular Cell Adhesion Molecule-1 / Vildagliptin
(徳島大学機関リポジトリ): ● Metadata: 114212
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.19-117
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31735774; ● Summary page in Scopus @ Elsevier: 2-s2.0-85075961168

(徳島大学機関リポジトリ: 114212, DOI: 10.1536/ihj.19-117, PubMed: 31735774, Elsevier: Scopus) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Association of Echocardiography Before Major Elective Non-Cardiac Surgery With Improved Postoperative Outcomes - Possible Implications for Patient Care.,
Circulation Journal, Vol.83, No.12, 2512-2519, 2019.

(要約): Whether preoperative echocardiography improves postoperative outcomes is not well established, so we examined the value of echocardiographic assessment on the onset of postoperative heart failure (HF), and determining which patients benefitted most from undergoing echocardiography prior to major elective non-cardiac surgery.Methods and Results:We identified all patients aged 50 years and older who had major elective non-cardiac surgery, and excluded patients with previously identified severe cardiovascular disease. The primary endpoint was the onset of HF during hospitalization. A total of 806 patients were included in the analysis. During hospitalization, 49 patients (6%) reached the primary endpoint. Within the matched cohort, preoperative echocardiography was associated with a statistically significant decrease in postoperative HF (hazard ratio: 0.46, P=0.01). In subgroup analyses, age, sex, body surface area, hypertension, diabetes mellitus, prior HF, surgical type, chronic kidney disease, pulmonary disease, and malignancy influenced the association of echocardiography with postoperative HF. The use of echocardiography in elderly patients with certain risk factors was associated with improved postoperative outcomes. The basis for this finding remains to be determined; particularly whether echocardiography is simply a marker of a population with better outcomes or whether it leads to better management that improves outcomes.
(キーワード): Aged / Echocardiography / Female / Heart Failure / Humans / Incidence / Japan / Male / Middle Aged / Predictive Value of Tests / Preoperative Care / Retrospective Studies / Risk Assessment / Risk Factors / Surgical Procedures, Operative / Time Factors / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 114189
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-19-0663
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31611537; ● Search Scopus @ Elsevier (PMID): 31611537; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-19-0663

(徳島大学機関リポジトリ: 114189, DOI: 10.1253/circj.CJ-19-0663, PubMed: 31611537) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijoh, Yuta Torii, nao Yamada, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension-Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, 2019.

(徳島大学機関リポジトリ): ● Metadata: 114191
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(徳島大学機関リポジトリ: 114191, DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) PT Pham, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice,
Scientific Reports, Vol.9, No.1, 11206, 2019.

(要約): Activated factor X (FXa) plays a central role in the coagulation cascade, while it also mediates vascular function through activation of protease-activated receptors (PARs). Here, we examined whether inhibition of FXa by rivaroxaban, a direct FXa inhibitor, attenuates endothelial dysfunction in streptozotocin (STZ)-induced diabetic mice. Induction of diabetes increased the expression of a major FXa receptor, PAR2, in the aorta (P < 0.05). Administration of rivaroxaban (10 mg/kg/day) to diabetic wild-type (WT) mice for 3 weeks attenuated endothelial dysfunction as determined by acetylcholine-dependent vasodilation compared with the control (P < 0.001), without alteration of blood glucose level. Rivaroxaban promoted eNOS phosphorylation in the aorta (P < 0.001). Induction of diabetes to PAR2-deficient (PAR2) mice did not affect endothelial function and eNOS phosphorylation in the aorta compared with non-diabetic PAR2 mice. FXa or a PAR2 agonist significantly impaired endothelial function in aortic rings obtained from WT mice, but not in those from PAR2 mice. FXa promoted JNK phosphorylation (P < 0.01) and reduced eNOS phosphorylation (P < 0.05) in human coronary artery endothelial cells (HCAEC). FXa-induced endothelial dysfunction in aortic rings (P < 0.001) and eNOS phosphorylation (P < 0.05) in HCAEC were partially ameliorated by a JNK inhibitor. Rivaroxaban ameliorated diabetes-induced endothelial dysfunction. Our results suggest that FXa or PAR2 is a potential therapeutic target.
(徳島大学機関リポジトリ): ● Metadata: 114192
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-019-47474-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31371788; ● Search Scopus @ Elsevier (PMID): 31371788; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-47474-0

(徳島大学機関リポジトリ: 114192, DOI: 10.1038/s41598-019-47474-0, PubMed: 31371788) Yuta Torii, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Amano Rie, Yamao Masami, Zheng Robert, Yoshihito Saijoh, nao Yamada, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Updated Left Ventricular Diastolic Function Recommendations and Cardiovascular Events in Patients with Heart Failure Hospitalization,
Journal of the American Society of Echocardiography, Vol.32, No.10, 1286-1297, 2019.

(要約): Evaluation of diastolic dysfunction is crucial in determining elevated left atrial pressure. However, a validation of the long-term prognostic value of the newly proposed algorithm updated in 2016 has not been performed. The aim of the present study was to investigate the relative value of the updated 2016 diastolic dysfunction grading system for the incidence of readmission in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Two hundred thirty-two patients hospitalized with HF were retrospectively evaluated. Subjects were divided into two subgroups: those with HFrEF (n = 127) and those with HFpEF (n = 105). Readmission risk scores were calculated using the Yale Center for Outcomes Research and Evaluation HF, LACE index, and HOSPITAL scores. The primary end point was readmission following HF and cardiac death. Over a period of 24 months, 86 patients were either readmitted or died. Multivariate Cox analysis was performed on both the HFrEF and HFpEF groups. In the HFrEF group, both the 2009 and 2016 algorithms had superior incremental value for the association of the primary end point to several readmission risk scores. In the HFpEF group, only the 2016 algorithm led to significant improvement in association with the primary end point. The 2016 algorithm had incremental value over several readmission risk scores alone. The recommendations of the 2016 algorithm can be useful for readmission and cardiac mortality risk assessment in patients with HFrEF and HFpEF. The use of echocardiography to estimate elevated left atrial pressure appears to identify a higher risk group and may allow a more tailored approach to therapy.
(徳島大学機関リポジトリ): ● Metadata: 114193
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2019.06.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31378421; ● Summary page in Scopus @ Elsevier: 2-s2.0-85069976367

(徳島大学機関リポジトリ: 114193, DOI: 10.1016/j.echo.2019.06.006, PubMed: 31378421, Elsevier: Scopus) Daiju Fukuda, Sachiko Nishimoto, Kunduziayi Aini, Atsushi Tanaka, Tsuyoshi Nishiguchi, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Kiyoshi Masuda, Takuya Naruto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Issei Imoto, Takashi Akasaka, Michio Shimabukuro and Masataka Sata :
Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis,
Journal of the American Heart Association, Vol.8, No.7, e010860, 2019.

(要約): Background Toll-like receptor ( TLR ) 9 recognizes bacterial DNA , activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells. We investigated whether TLR 9 contributes to the development of vascular inflammation and atherogenesis using apolipoprotein E-deficient ( Apoe ) mice. Methods and Results Tlr9-deficient Apoe ( Tlr9 Apoe ) mice and Apoe mice on a Western-type diet received subcutaneous angiotensin II infusion (1000 ng/kg per minute) for 28 days. Angiotensin II increased the plasma level of double-stranded DNA, an endogenous ligand of TLR 9, in these mice. Genetic deletion or pharmacologic blockade of TLR 9 in angiotensin II-infused Apoe mice attenuated atherogenesis in the aortic arch ( P<0.05), reduced the accumulation of lipid and macrophages in atherosclerotic plaques, and decreased RNA expression of inflammatory molecules in the aorta with no alteration of metabolic parameters. On the other hand, restoration of TLR 9 in bone marrow in Tlr9 Apoe mice promoted atherogenesis in the aortic arch ( P<0.05). A TLR 9 agonist markedly promoted proinflammatory activation of Apoe macrophages, partially through p38 mitogen-activated protein kinase signaling. In addition, genomic DNA extracted from macrophages promoted inflammatory molecule expression more effectively in Apoe macrophages than in Tlr9 Apoe macrophages. Furthermore, in humans, circulating double-stranded DNA in the coronary artery positively correlated with inflammatory features of coronary plaques determined by optical coherence tomography in patients with acute myocardial infarction ( P<0.05). Conclusions TLR 9 plays a pivotal role in the development of vascular inflammation and atherogenesis through proinflammatory activation of macrophages. TLR 9 may serve as a potential therapeutic target for atherosclerosis.
(キーワード): Aged / Angiotensin II / Animals / Aorta, Thoracic / 動脈硬化 (atherosclerosis) / Bone Marrow Transplantation / Cell-Free Nucleic Acids / Chemokine CCL2 / 女性 (female) / Humans / In Vitro Techniques / 炎症 (inflammation) / Lipids / Macrophages / Macrophages, Peritoneal / 男性 (male) / Mice / ノックアウトマウス (knockout mice) / Mice, Knockout, ApoE / Microscopy, Electron / Myocardial Infarction / Percutaneous Coronary Intervention / Plaque, Atherosclerotic / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Toll-Like Receptor 9 / Tomography, Optical Coherence / Tumor Necrosis Factor-alpha / Vasoconstrictor Agents
(徳島大学機関リポジトリ): ● Metadata: 113231
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/JAHA.118.010860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30905257; ● Summary page in Scopus @ Elsevier: 2-s2.0-85063712345

(徳島大学機関リポジトリ: 113231, DOI: 10.1161/JAHA.118.010860, PubMed: 30905257, Elsevier: Scopus) Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Sae Morita, Yuta Torii, Susumu Nishio, Robert Zheng, Yoshihito Saijo, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Left atrial functional response after a marathon in healthy amateur volunteers,
The International Journal of Cardiovascular Imaging, Vol.35, No.4, 633-643, 2019.

(要約): Middle-aged marathon runners have an increased risk of developing atrial fibrillation (AF). A previous study described that repetitive marathon running was associated with left atrial (LA) dysfunction. However, whether this change is common in marathon runners and which runners are at risk of LA dysfunction remain unknown. The purpose of this study was to determine which factors could predict LA dysfunction. We prospectively examined 12 healthy amateur volunteers (9 males, 31 ± 8 years old) who participated in a full marathon. All echocardiographic measurements and speckle-tracking echocardiography were performed before and after the marathon. The endpoint was defined as reduced LA reservoir strain 1 day after the marathon (non-responder group). Seven participants were in the non-responder group. Age (35 ± 9 vs. 26 ± 2 years, p = 0.020), augmentation index (76 ± 12 vs. 55 ± 8, p = 0.002), and diastolic blood pressures (83 ± 11 vs. 70 ± 7 mmHg, p = 0.021) in the non-responder group were significantly higher compared with the responder group. In multivariate linear regression analysis, only the augmentation index was an independent predictor of reduced LA reservoir function after the marathon (β = - 0.646, p = 0.023). The augmentation index was a predictive marker for reduction in LA reservoir function after a marathon in healthy amateur volunteers.
(キーワード): Adaptation, Physiological / Adult / Atrial Fibrillation / Atrial Function, Left / Atrial Remodeling / Echocardiography, Doppler / 女性 (female) / Healthy Volunteers / Humans / 男性 (male) / Middle Aged / Physical Endurance / Prospective Studies / Risk Factors / Running / Time Factors / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 113069
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-018-1502-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30470971; ● Summary page in Scopus @ Elsevier: 2-s2.0-85057125051

(徳島大学機関リポジトリ: 113069, DOI: 10.1007/s10554-018-1502-2, PubMed: 30470971, Elsevier: Scopus) Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome,
Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019.

(要約): It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR.
(キーワード): Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / 女性 (female) / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / 男性 (male) / Prognosis / Retrospective Studies / Risk Factors / Stents
(徳島大学機関リポジトリ): ● Metadata: 113220
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.44735
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329; ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735

(徳島大学機関リポジトリ: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus) 高橋未奈, 飛梅威, 松本和久, 松浦朋美, 添木武, 藤本裕太, 原田貴文, Zheng Robert, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
大動脈弁人工弁(機械弁)置換術後遠隔期に生じたOMI-VT stormに対し経心房中隔的に施行したカテーテルアブレーションが著効した1例,
四国医学雑誌, Vol.74, No.56, 201-208, 2019年.

(要約): A 68-year-old woman with VT storm and frequent appropriate ICD therapy was referred for catheter ablation. Her past history was notable for aortic valve replacement by mechanical valve due to infectious endocarditis 17 years prior to presentation and left ventricular apical old myocardial infarction with unknown onset. At 67 years old, She admitted to the prior hospital due to ventricular tachycardia with LBBB and superior axis at heart rate of 210 per minutes. Administration of amiodarone and magnesium sulfate was ineffective and cardioversion of 200J was successfully terminated the tachycardia. Intra-cardiac defibrillator was implanted and the administration of amiodarone and mexiletine was started. 5 months after, she admitted to the hospital due to the frequent appropriate shock against the same ventricular tachycardia. Administration of lidocaine, sotalol, pilsicainide, and magnesium sulfate could not control the tachycardia and she was referred to our hospital for catheter ablation. During the first session, ventricular tachycardia was easily induced and electroanatomical mapping was performed both during tachycardia and during sinus rhythm. Late diastolic potential preceding the onset of QRS wave by 45ms was detected at the infero-septal side of the apical aneurysm. 7 5s of the RF energy application at this site could terminate the tachycardia and thereafter no ventricular tachycardia was induced. But after dose-reduction or cessation of some anti-arrhythmic drugs, ventricular tachycardia was recurred and second session was performed. This time, no ventricular tachycardia was induced, then we performed isthmus transection and core isolation against the apical aneurysm. Thereafter no ventricular tachycardia was occurred in spite of dose-reduction or cessation of some anti-arrhythmic drugs.
(キーワード): ventricular tachycardia / storm / old myocardial infarction / catheter ablation / aortic valve replacement
(徳島大学機関リポジトリ): ● Metadata: 112988
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001338015711104

(徳島大学機関リポジトリ: 112988, CiNii: 1050001338015711104) Shusuke Yagi, Robert Zheng, Seiichi Nishiyama, Yutaka Kawabata, Takayuki Ise, Kosuke Sugiura, Haruhiko Yoshinari, Toshihiko Nishisho, Yoshimi Bando, Kumiko Kagawa, Daiju Fukuda, Tomohiro Soga, Yoshihito Saijoh, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito, Masashi Akaike and Masataka Sata :
Osteolytic primary bone lymphoma in the multiple bones,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 347-350, 2019.

(要約): Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114167
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.347
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656303; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074142443

(徳島大学機関リポジトリ: 114167, DOI: 10.2152/jmi.66.347, PubMed: 31656303, Elsevier: Scopus) Shusuke Yagi, Itsuro Endo, Taichi Murakami, Tetsuya Hida, Yousuke Yamamoto, Tomohiro Soga, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito and Masataka Sata :
Adult onset of Immunoglobulin A vasculitis - A case report,,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 344-346, 2019.

(要約): Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, primarily occurs during childhood between the ages of 3 and 15 years and is the most common form of systemic vasculitis in children ; its occurrence in adults has been rarely reported. Such low incidence could be attributable to either under-diagnosis or misdiagnosis. Thus, not only pediatricians but also physicians should be able to diagnose IgAV accurately to manage the patients appropriately and avoid its associated complications. In addition, treatment of adult onset IgAV with renal involvement has not been fully established yet. We describe here a case of adult onset IgAV complicated by proteinuria and pharyngitis, which was cured by no specific treatment. J. Med. Invest. 66 : 344-346, August, 2019.
(キーワード): Acetaminophen / Adult / Factor XIII / Humans / Immunoglobulin A / Male / Pharyngitis / Proteinuria / Purpura, Schoenlein-Henoch
(徳島大学機関リポジトリ): ● Metadata: 114166
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.344
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656302; ● Search Scopus @ Elsevier (PMID): 31656302; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.344

(徳島大学機関リポジトリ: 114166, DOI: 10.2152/jmi.66.344, PubMed: 31656302) Shusuke Yagi, Rie Ueno, Kumiko Sutou, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshihito Saijo, Tomoya Hara, Takayuki Ise, Kenya Kusunose, Mika Bando, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Lambda-like J wave due to acute myocardial infarction of the diagonal branch,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 185-187, 2019.

(要約): The culprit lesion of acute myocardial infarction could be predicted by electrocardiogram findings. However, we experienced some cases with coronary angiographic finding in the area of ST-T elevation that was different from that predicted. The lambda-like J wave could be caused by ischemia although the mechanism has not been fully elucidated. We report a case of acute myocardial infarction that showed discrepancy between ST-T elevation with lambda-like ischemic J wave in a broad area and coronary angiographical finding of diagonal branch occlusion. J. Med. Invest. 66 : 185-187, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113420
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.185
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064936; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065772885

(徳島大学機関リポジトリ: 113420, DOI: 10.2152/jmi.66.185, PubMed: 31064936, Elsevier: Scopus) Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia,
Frontiers in Cardiovascular Medicine, Vol.5, 144, 2018.

(要約): Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. However, the role of TLR9, which was originally known as a sensor for bacterial DNA, remains unknown. This study investigated the role of TLR9 in blood flow recovery in the ischemic limb using a mouse hind-limb ischemia model. Unilateral femoral artery ligation was performed in TLR9-deficient () mice and wild-type mice. In wild-type mice, femoral artery ligation significantly increased mRNA expression of TLR9 in the ischemic limb ( < 0.001) and plasma levels of cell-free DNA (cfDNA) as determined by single-stranded DNA (ssDNA) ( < 0.05) and double-stranded DNA (dsDNA) ( < 0.01), which are endogenous ligands for TLR9, compared with the sham-operated group. Laser Doppler perfusion imaging demonstrated significantly improved ratio of blood flow in the ischemic to non-ischemic limb in mice compared with wild-type mice at 2 weeks after ligation ( < 0.05). mice showed increased capillary density and reduced macrophage infiltration in ischemic limb. Genetic deletion of TLR9 reduced the expression of TNF-α, and attenuated NF-κB activation in ischemic muscle compared with wild-type mice ( < 0.05, respectively) at 3 days after the surgery. ODN1826, a synthetic agonistic oligonucleotide for TLR9, or plasma obtained from mice with ischemic muscle promoted the expression of TNF-α in wild-type macrophages ( < 0.05), but not in macrophages. ODN1826 also activated NF-κB signaling as determined by the degradation of IκBα in wild-type macrophages ( < 0.05), but not in macrophages. In vitro experiments using human umbilical vein endothelial cells demonstrated that TNF-α, or conditioned medium obtained from wild-type macrophages treated with ODN1826 accelerated cell death as determined by MTS assay ( < 0.05 and < 0.01, respectively). Our results suggest that ischemic muscle releases cfDNA, which activates TLR9 and enhances inflammation, leading to impairment of blood flow recovery in the ischemic limb. cfDNA-TLR9 signaling may serve as a potential therapeutic target in ischemic limb disease.
(徳島大学機関リポジトリ): ● Metadata: 113226
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fcvm.2018.00144
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30460242; ● Search Scopus @ Elsevier (PMID): 30460242; ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2018.00144

(徳島大学機関リポジトリ: 113226, DOI: 10.3389/fcvm.2018.00144, PubMed: 30460242) B Ganbaatar, Daiju Fukuda, HM Salim, Sachiko Nishimoto, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice.,
Atherosclerosis, Vol.275, 124-132, 2018.

(要約): Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe) mice. Eight-week-old male apoe mice were fed a western-type diet (WTD) supplemented with 0.1% ticagrelor (approximately 120 mg/kg/day). Non-treated animals on WTD served as control. Atherosclerotic lesions were examined by en-face Sudan IV staining, histological analyses, quantitative RT-PCR analysis, and western blotting. Endothelial function was analyzed by acetylcholine-dependent vasodilation using aortic rings. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments. Ticagrelor treatment for 20 weeks attenuated atherosclerotic lesion progression in the aortic arch compared with control (p < 0.05). Ticagrelor administration for 8 weeks attenuated endothelial dysfunction (p < 0.01). Ticagrelor reduced the expression of inflammatory molecules such as vascular cell adhesion molecule-1, macrophage accumulation, and lipid deposition. Ticagrelor decreased the phosphorylation of JNK in the aorta compared with control (p < 0.05). Ticagrelor and a JNK inhibitor ameliorated impairment of endothelium-dependent vasodilation by adenosine diphosphate (ADP) in wild-type mouse aortic segments. Furthermore, ticagrelor inhibited the expression of inflammatory molecules which were promoted by ADP in HUVEC (p < 0.001). Ticagrelor also inhibited ADP-induced JNK activation in HUVEC (p < 0.05). Ticagrelor attenuated vascular dysfunction and atherogenesis through the inhibition of inflammatory activation of endothelial cells. These effects might be a potential mechanism by which ticagrelor decreases cardiovascular events in patients with ACS.
(徳島大学機関リポジトリ): ● Metadata: 114201
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2018.05.053
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29902700; ● Search Scopus @ Elsevier (PMID): 29902700; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2018.05.053

(徳島大学機関リポジトリ: 114201, DOI: 10.1016/j.atherosclerosis.2018.05.053, PubMed: 29902700) Yoshihito Saijo, Hirotsugu Yamada, Kenya Kusunose, Mika Bando, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure.,
Echocardiography, Vol.35, No.10, 1587-1595, 2018.

(要約): To improve the prognosis of patients with heart failure, risk stratification in their early stage is important. We assessed whether the change in transmitral flow (TMF) velocity pattern during preload augmentation can predict future hemodynamic worsening in early-stage heart failure patients with impaired relaxation TMF pattern. We designed a prospective cohort study that included 155 consecutive patients with impaired relaxation (IR) pattern at rest. Preload stress echocardiography was achieved using leg-positive pressure (LPP), and changes in TMF pattern during the LPP was observed during baseline echocardiographic examination. The patients whose TMF pattern developed to pseudonormal (PN) pattern throughout the study period were classified into the change to PN group, and patients whose TMF pattern stayed in IR pattern were classified into the stay in IR group. The median follow-up period was 17 months. The average age was 68 ± 11 years old, and 97 patients (63%) were male. Among 155 patients, 27 were classified into the change to PN group. A Cox proportional hazard analysis confirmed that the change in the peak atrial systolic TMF velocity during the LPP (ΔA, hazard ratio = 0.58 per 1SD; 95% CI = 0.39-0.88, P = 0.010) was the powerful independent predictor of change into PN pattern. Kaplan-Meier analysis revealed that the patients with ΔA -7 cm/s had more likely to develop into PN pattern than patients with ΔA > -7 cm/s (P = 0.001). Evaluation of a response in TMF during the LPP might provide an incremental diagnostic value to detect future overt heart failure in patients with early-stage heart failure.
(徳島大学機関リポジトリ): ● Metadata: 112877
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/echo.14098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30005132; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054773574

(徳島大学機関リポジトリ: 112877, DOI: 10.1111/echo.14098, PubMed: 30005132, Elsevier: Scopus) Kenya Kusunose, Hiromitsu Seno, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure.,
The Canadian Journal of Cardiology, Vol.34, No.10, 1307-1315, 2018.

(要約): It has been recognized that a comprehensive cardiac rehabilitation (CR) program improves mortality in patients with chronic heart failure. On the other hand, the magnitude of the improvement in exercise capacity after CR differs among individuals. The aim of this study was to assess the echocardiographic determinants of responders to CR using preload stress echocardiography. We prospectively enrolled 58 chronic heart failure patients with reduced left ventricular ejection fraction (aged 62 ± 11 years; 69% male; left ventricular ejection fraction 43% ± 7%) who had received optimized medical treatment in a CR program for 5 months. We performed preload echocardiographic studies using leg positive pressure (LPP) to assess the echocardiographic parameters during preload augmentation. We defined 41 patients as a development cohort to assess the predictive value of echocardiographic variables. Next, we validated results in the remaining 17 patients as a validation cohort. In the development cohort, significant improvement in peak oxygen uptake (VO) (>10%) after CR was observed in 58% patients. In a multivariable logistic regression model, the significant predictor of improvement in exercise capacity was right ventricular (RV) strain during LPP (odds ratio: 3.96 per 1 standard deviation; P = 0.01). An RV strain value of -16% during LPP had a good sensitivity of 0.79 and a specificity of 0.71 to identify patients with improvement in peak VO. In the validation cohort, an optimal cutoff value of RV strain value was the same (area under the curve: 0.77, sensitivity: 0.78, specificity: 0.65). RV strain during LPP may be an echocardiographic parameter for assessing beneficial effects of CR.
(徳島大学機関リポジトリ): ● Metadata: 114204
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cjca.2018.06.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30146462; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052061274

(徳島大学機関リポジトリ: 114204, DOI: 10.1016/j.cjca.2018.06.003, PubMed: 30146462, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Sachiko Bando, Matsumoto Kazuhisa, Hiromi Nagano, Etsuko Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation.,
Circulation Journal, Vol.82, No.9, 2253-2258, 2018.

(要約): The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters.Methods and Results:We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9-93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age 58 years, PAC count 80 beats/day, maximum RR interval 1.64 s, and LAD 4.5 cm were independently associated with the development of AF. The incidence rate of new-onset AF significantly increased as the combined score (i.e., the sum of the risk score determined using hazard ratios) increased. A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF.
(徳島大学機関リポジトリ): ● Metadata: 113221
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-0758
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848884; ● Summary page in Scopus @ Elsevier: 2-s2.0-85052204332

(徳島大学機関リポジトリ: 113221, DOI: 10.1253/circj.CJ-17-0758, PubMed: 29848884, Elsevier: Scopus) Kageyuki Oba, Minetaka Maeda, Gulinu Maimaituxun, Satoshi Yamaguchi, Osamu Arasaki, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Susumu Nishio, Takashi Iwase, Shoichiro Takao, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Hiroaki Masuzaki, Masataka Sata and Michio Shimabukuro :
Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation.,
Circulation Journal, Vol.82, No.7, 1778-1787, 2018.

(要約): Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results:Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m, P<0.01). The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.
(徳島大学機関リポジトリ): ● Metadata: 113224
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29806623; ● Summary page in Scopus @ Elsevier: 2-s2.0-85049036945

(徳島大学機関リポジトリ: 113224, DOI: 10.1253/circj.CJ-18-0021, PubMed: 29806623, Elsevier: Scopus) Kenya Kusunose, Y Okushi, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Frailty and Diastolic Dysfunction in Elderly Patients.,
Circulation Journal, Vol.82, No.8, 2103-2110, 2018.

(要約): High prevalence of frailty and of diastolic dysfunction (DD) in heart failure and high mortality in frail adults have been noted. We characterized frailty by quantifying differences on echocardiography, and assessed the added prognostic utility of frailty and DD grade in an elderly population. One hundred and ninety-one patients 65 years who had at least 1 cardiovascular risk factor were prospectively recruited for clinically indicated echocardiography at the present institute. Weight loss, exhaustion, and deficits in physical activity, gait speed, and handgrip strength were used to categorize patients as frail (3 features), intermediately frail (1 or 2 features), or non-frail (0 features). DD grade 2 was defined as severe. Frailty was associated with larger left atrial volume, smaller stroke volume, and worse DD grade after adjustment for age. In a period of 14 months, 29 patients (15%) had cardiovascular events. The addition of frailty score and severe DD significantly improved the prognostic power of a model containing male gender (model 1, male gender, χ=6.4; model 2, model 1 plus frailty score, χ=16.7, P=0.004; model 3, model 2 plus severe DD, χ=25.5, P=0.015). Both frailty and DD grade were significantly associated with future cardiovascular events in an elderly population with preserved ejection fraction and 1 risk factor of cardiovascular disease.
(徳島大学機関リポジトリ): ● Metadata: 113222
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-18-0017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29709994; ● Summary page in Scopus @ Elsevier: 2-s2.0-85050588123

(徳島大学機関リポジトリ: 113222, DOI: 10.1253/circj.CJ-18-0017, PubMed: 29709994, Elsevier: Scopus) Gulinu Maimaituxun, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Shoichiro Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease - New Prediction Model in Combination With Framingham Risk Score.,
Circulation Journal, Vol.82, No.5, 1369-1378, 2018.

(要約): Compared with global cardiac adiposity, the local accumulation of fat surrounding coronary arteries might have a more direct impact on coronary artery disease (CAD). Here, we compared the local epicardial adipose tissue (EAT) thickness and global cardiac adiposity volumes for predicting CAD.Methods and Results:A total of 197 consecutive subjects underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into CAD (1 coronary artery branch stenosis 50%) and non-CAD groups. EAT thickness was measured at the right coronary artery (EAT), the left anterior descending artery (EAT), and the left circumflex artery (EAT). Although EATand EATwere similar between the 2 groups, EATwas larger in the CAD group than in the non-CAD group (5.45±2.16 mm vs. 6.86±2.19 mm, P<0.001). EAT, after correcting for confounding factors, was strongly associated with CAD (r=0.276, P<0.001) and Gensini score (r=0.239, P<0.001). On multiple regression analysis, Framingham risk score combined with EATwas a strong predictor of CAD (adjusted R=0.121; P<0.001). The local fat thickness surrounding the LAD is a simple and useful surrogate marker for estimating the presence, severity, and extent of CAD, independent of classical cardiovascular risk factors.
(徳島大学機関リポジトリ): ● Metadata: 112879
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-17-1289
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29563352; ● Summary page in Scopus @ Elsevier: 2-s2.0-85045965929

(徳島大学機関リポジトリ: 112879, DOI: 10.1253/circj.CJ-17-1289, PubMed: 29563352, Elsevier: Scopus) 清水郁子, 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 岩瀬俊, 黒部裕嗣, 北川哲也 :
Calcified Amorphous Tumorに対し腫瘍摘出術を行った一例,
四国医学雑誌, Vol.74, No.1-2, 84, 2018年. Tomoya Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Yukina Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire-mediated vascular injury.,
European Journal of Pharmacology, Vol.5, No.820, 222-228, 2018.

(要約): Accumulating evidence suggests that activated factor X (FXa), a key coagulation factor, plays an important role in the development of vascular inflammation through activation of many cell types. Here, we investigated whether pharmacological blockade of FXa attenuates neointima formation after wire-mediated vascular injury. Transluminal femoral artery injury was induced in C57BL/6 mice by inserting a straight wire. Rivaroxaban (5mg/kg/day), a direct FXa inhibitor, was administered from one week before surgery until killed. At four weeks after surgery, rivaroxaban significantly attenuated neointima formation in the injured arteries compared with control (P<0.01). Plasma lipid levels and blood pressure were similar between the rivaroxaban-treated group and non-treated group. Quantitative RT-PCR analyses demonstrated that rivaroxaban reduced the expression of inflammatory molecules (e.g., IL-1β and TNF-α) in injured arteries at seven days after surgery (P<0.05, respectively). In vitro experiments using mouse peritoneal macrophages demonstrated that FXa increased the expression of inflammatory molecules (e.g., IL-1β and TNF-α), which was blocked in the presence of rivaroxaban (P<0.05). Also, in vitro experiments using rat vascular smooth muscle cells (VSMC) demonstrated that FXa promoted both proliferation and migration of this cell type (P<0.05), which were blocked in the presence of rivaroxaban. Inhibition of FXa by rivaroxaban attenuates neointima formation after wire-mediated vascular injury through inhibition of inflammatory activation of macrophages and VSMC.
(徳島大学機関リポジトリ): ● Metadata: 114209
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2017.12.037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29269019; ● Summary page in Scopus @ Elsevier: 2-s2.0-85039155853

(徳島大学機関リポジトリ: 114209, DOI: 10.1016/j.ejphar.2017.12.037, PubMed: 29269019, Elsevier: Scopus) Hiromu Yamazaki, Shusuke Yagi, Yuta Torii, Rie Amano, Yasuyuki Oomichi, Teruaki Sangawa, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels,
Journal of Cardiology, Vol.71, No.3, 305-309, 2017.

(要約): It is well known that warfarin inhibits the synthesis of vitamin K-dependent anticoagulants, including thrombin, protein C and S, and factor Xa, leading, paradoxically, to an initial hypercoagulable state. Edoxaban, a direct inhibitor of activated factor X is widely used for the treatment of acute venous thromboembolism (VTE). However, the effect of edoxaban on circulating coagulation factors, in patients with acute VTE, remains unknown. We enrolled 57 patients with acute VTE with/without pulmonary embolism treated with edoxaban (n=37) or warfarin (n=20) in a clinical setting. Before treatment and 2 weeks after treatment, we evaluated thrombotic burden using ultrasound or computed tomography angiography. We also evaluated thrombin generation, represented by prothrombin fragment F1+2; thrombus degradation, represented by D-dimer; and levels of anticoagulants, including protein C, protein S, and antithrombin III. Both edoxaban and warfarin treatment improved thrombotic burden and decreased prothrombin fragment F1+2, and D-dimer. Edoxaban treatment preserved protein C and protein S levels. In contrast, warfarin decreased protein C and protein S levels. Neither treatment affected antithrombin III. Edoxaban improves VTE while preserving protein C and protein S levels, thereby indicating that edoxaban improves thrombotic burden while maintaining levels of anticoagulants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2017.09.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29100817; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032912457

(DOI: 10.1016/j.jjcc.2017.09.009, PubMed: 29100817, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Takeshi Kondo, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Daiju Fukuda, Yutaka Nakaya, Kin-Ichiro Suwaki, Takashi Takeji, Toshihiro Wada, Masdan Hotimah Salim, Saori Hama, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Munehide Matsuhisa, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus.,
Advances in Therapy, Vol.35, No.1, 124-134, 2017.

(要約): Predictors for the effect of sodium glucose co-transporter 2 (SGLT2) inhibitors at lowering hemoglobin A1c (HbA1c) levels in type 2 diabetes mellitus patients remain unclear. We therefore aimed to elucidate these predictors in type 2 diabetes patients after 3 months of SGLT2 treatment. A total of 302 consecutive type 2 diabetes patients who had been treated with SGLT2 inhibitors as monotherapy or add-on therapy to existing antidiabetic treatments were enrolled retrospectively. After excluding 27 patients whose HbA1c levels could not be evaluated 3 months after treatment, the glucose-lowering effects of SGLT2 inhibitors were assessed in 275 patients by measuring HbA1c levels before and 3 months after treatment. The predictors for changes in HbA1c levels after 3 months of treatment were evaluated. SGLT2 inhibitor treatment for 3 months decreased HbA1c levels from 7.8 ± 1.2% to 7.4 ± 1.0% (p < 0.0001). A multiple regression analysis showed that the independent determinants for SGLT2 inhibitor treatment effect included decreased HbA1c levels after 1 month of treatment, high baseline HbA1c levels, and a high estimated glomerular filtration rate (eGFR). We show that type 2 diabetes patients who received the greatest glucose-lowering effect with SGLT2 inhibitor treatment were those with preserved renal function (high baseline eGFR) and high baseline HbA1c levels. Moreover, SGLT2 inhibitor treatment efficacy could be predicted by the patients' initial response to treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12325-017-0639-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29185199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035102977

(DOI: 10.1007/s12325-017-0639-z, PubMed: 29185199, Elsevier: Scopus) Shusuke Yagi, Takeshi Soeki, Ken-Ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome,
International Heart Journal, Vol.58, No.5, 720-723, 2017.

(要約): The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.
(キーワード): Adult / Aged / Aged, 80 and over / Biomarkers / Brugada Syndrome / Chromatography, Gas / Docosahexaenoic Acids / Eicosapentaenoic Acid / Electrocardiography / Follow-Up Studies / Humans / Incidence / 日本 (Japan) / Male / Middle Aged / Prevalence / ROC Curve / Retrospective Studies / Risk Assessment / Risk Factors / Syncope / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-278
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966307; ● CiNii @ 国立情報学研究所 (CRID): 1390282680202467328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032215381

(DOI: 10.1536/ihj.16-278, PubMed: 28966307, CiNii: 1390282680202467328, Elsevier: Scopus) Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Koji Nishikawa, Daiju Fukuda, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Shinsuke Katoh, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.,
International Heart Journal, Vol.58, No.5, 746-751, 2017.

(要約): Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.
(キーワード): Body Composition / Cardiac Rehabilitation / Exercise Tolerance / Female / Follow-Up Studies / 心不全 (heart failure) / Humans / Intra-Abdominal Fat / Male / Middle Aged / 肥満症 (obesity) / 酸素消費 (oxygen consumption) / Prognosis / Retrospective Studies / Weight Loss
(徳島大学機関リポジトリ): ● Metadata: 110111
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-454
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966316; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032221042

(徳島大学機関リポジトリ: 110111, DOI: 10.1536/ihj.16-454, PubMed: 28966316, Elsevier: Scopus) Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Salim Masdan Hotimah, G Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Michio Shimabukuro and Masataka Sata :
Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus.,
Diabetology & Metabolic Syndrome, Vol.9, 78, 2017.

(要約): It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 ± 0.5% to 6.7 ± 0.6% (P < 0.05) and decreased EAT thickness from 9.3 ± 2.5 to 7.3 ± 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).
(徳島大学機関リポジトリ): ● Metadata: 114544
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13098-017-0275-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29034006; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030465923

(徳島大学機関リポジトリ: 114544, DOI: 10.1186/s13098-017-0275-4, PubMed: 29034006, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients With Preserved Ejection FractionandLow-GradientAorticStenosis,
Circulation. Cardiovascular Imaging, Vol.10, No.10, 2017.

(要約): The projected aortic valve area (AVA) at a normal transvalvular flow rate using dobutamine is helpful to determine the actual severity of aortic stenosis (AS) and to predict risk of adverse events in low-gradient AS cases with unclear surgical indication. Our study aimed to identify the independent and incremental value of preload stress echocardiography-derived AVA to predict outcomes in patients with preserved ejection fraction and low-gradient AS. We prospectively performed echocardiographic studies in 79 patients with low-gradient AS (age, 77±7 years; 30% men) with preload stress echocardiography using leg positive pressure. AVA was calculated using AVA and transvalvular flow rate at baseline and during leg positive pressure. The primary end point was the decision for aortic valve surgery or cardiac death. During a median period of 19 months, 23 patients had the decision for aortic valve surgery, and none died during follow-up. In a stepwise multivariable analysis, indexed AVA (AVAi; hazard ratio, 2.00 per 0.1 cm/m decrease; 95% confidence interval, 1.36-2.96; <0.001) was associated with the primary end point. Using a receiver operating characteristic curve analysis, the best cutoff value of AVAi for predicting cardiac events was <0.72 cm/m. By incorporating AVAi into AVAi at baseline, continuous net reclassification index for cardiac events was 0.48 (=0.04). In patients with low-gradient AS, indexed AVA derived from preload stress echocardiography can be useful to predict risk of adverse events. The present article should be considered as a proof of concept study, and we think that larger multicenter studies are warranted.
(キーワード): Aged / Aged, 80 and over / Aortic Valve / Aortic Valve Stenosis / Area Under Curve / Disease Progression / Disease-Free Survival / Echocardiography, Stress / Female / Humans / Kaplan-Meier Estimate / Male / Models, Cardiovascular / Predictive Value of Tests / Prospective Studies / ROC Curve / Severity of Illness Index / Stroke Volume / Time Factors / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCIMAGING.117.006690
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29021259; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031850278

(DOI: 10.1161/CIRCIMAGING.117.006690, PubMed: 29021259, Elsevier: Scopus) Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing.,
Journal of the American Society of Echocardiography, Vol.30, No.10, 1021-1027, 2017.

(要約): Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasm with angina (VSA) causes endothelial dysfunction in the coronary arteries. The aim of this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA. Sixty-five patients who underwent intracoronary acetylcholine provocation testing for clinical indications were prospectively enrolled. VSA was diagnosed by coronary artery stenosis increase of >90% and the presentation of chest pain with ischemic changes on electrocardiography. Subjects were divided into two groups, with and without significant coronary spasm (VSA group, 30 patients; non-VSA group, 35 patients), consistent with acetylcholine provocation testing. EAT-AIG thickness was significantly greater in the VSA group than in the non-VSA group (8.2 2.7 vs 6.1 2.5 mm, P = .002). By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). EAT-AIG thickness had incremental diagnostic value over other conventional risk factors (area under the curve = 0.81 vs 0.64, P for comparison = .020). EAT-AIG thickness, which is noninvasively and easily measured using transthoracic echocardiography, can be one of multiple clinical variables associated with VSA.
(徳島大学機関リポジトリ): ● Metadata: 110928
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2017.06.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28843368; ● Search Scopus @ Elsevier (PMID): 28843368; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2017.06.024

(徳島大学機関リポジトリ: 110928, DOI: 10.1016/j.echo.2017.06.024, PubMed: 28843368) Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Rikuto Shimizu, Yuta Torii, Susumu Nishio, Yoshihito Saijo, Shoichiro Takao, Takeshi Soeki and Masataka Sata :
Age-related changes in morphology of left atrial appendage in patients with atrial fibrillation.,
The International Journal of Cardiovascular Imaging, Vol.34, No.2, 321-328, 2017.

(要約): The purpose of this study was to evaluate the relationship between age and frequency of left atrial appendage (LAA) morphology in patients with atrial fibrillation (AF) compared with sinus rhythm (SR). We enrolled 145 AF patients, and 199 SR patients for the control group without any cardiovascular disease. LAA volume index (LAAVi) and morphology were assessed by electrocardiogram-gated computed tomography angiography. LAA morphology was classified into "chicken wing" or "non-chicken wing" according to the previously described classification. There was no significant trend in frequency of non-chicken wing morphology among ages in the SR group (p = 0.36 for trend), whereas the frequency was negatively related to age in the AF group (p = 0.002 for trend). In multivariable logistic regression, age > 65 (odds ratio [OR] 0.42, p = 0.002) and duration of AF (OR 0.53, p = 0.010) and LAAVi (OR 0.62, p = 0.017) were independent factors of non-chicken wing LAA morphology in the AF group. LAA morphology is affected by age, especially in patients with AF. When we utilize non-chicken wing LAA morphology as a stroke risk factor in patients with AF, we should pay attention to their age.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10554-017-1232-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28808846; ● Search Scopus @ Elsevier (PMID): 28808846; ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-017-1232-x

(DOI: 10.1007/s10554-017-1232-x, PubMed: 28808846) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Predictors for Worsening of Six-Minute Walk Distances in Patients With Systemic Sclerosis (Scleroderma),
The American Journal of Cardiology, Vol.120, No.2, 315-321, 2017.

(要約): Change in 6-minute walk distance (6MWD) has been used as a clinical marker in pulmonary hypertension. Determinants and worsening of 6MWD remain a matter of debate because nonpulmonary factors have an impact on the 6MWD. We hypothesized that future reduction of 6MWD in patients with systemic sclerosis (SSc) was more closely associated with cardiac dysfunction. We prospectively performed standard clinical and echocardiographic evaluations in SSc patients with the 6-minute walk test at enrollment. Features associated with the 6MWD were sought in a multiple linear regression analysis and compared using standardized . Worsening of the 6MWD was defined as a 15% reduction and served as the primary outcome. Eighty-one patients were included. In the multivariate analysis, baseline 6MWD was related to SSc severity score ( = -0.250, p = 0.024), left atrial volume index ( = -0.222, p = 0.046), right ventricular fractional area change ( = 0.252, p = 0.025), and the ratio of mean pulmonary artery pressure and cardiac output ( = -0.31, p = 0.002). During follow-up, 20 patients reached the primary outcome. In sequential Cox models, a model based on right ventricular fractional area change at baseline (chi-square 4.8) was improved by left atrial volume index (chi-square 10.3, p = 0.007). In conclusion, determinants and worsening of 6MWD are explained by cardiac factors. When using the 6MWD as a clinical marker in pulmonary hypertension patients, their left ventricular diastolic function and right ventricular systolic function should be taken into consideration.
(キーワード): Diastole / Disease Progression / Echocardiography, Doppler / Female / Follow-Up Studies / Humans / Hypertension, Pulmonary / Male / Middle Aged / Predictive Value of Tests / Prospective Studies / Scleroderma, Systemic / Stroke Volume / Systole / Time Factors / Ventricular Function, Left / Ventricular Function, Right / Walking
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2017.04.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28532772; ● Search Scopus @ Elsevier (PMID): 28532772; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2017.04.024

(DOI: 10.1016/j.amjcard.2017.04.024, PubMed: 28532772) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Ayumi Ishii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF,
JACC. Cardiovascular Imaging, Vol.10, No.10, 1240-1249, 2017.

(要約): The aim of this study was to assess the relationship between right ventricular (RV) function during pre-load augmentation and exercise tolerance. Peak oxygen uptake (VO2) is a strong predictor of mortality in chronic heart failure. Cardiac function during pre-load augmentation is an important part of the phenomenon in the evaluation of exercise capacity. We prospectively performed echocardiographic studies in 68 chronic heart failure patients with cardiopulmonary exercise testing (mean age 60 ± 12 years; 69% male). After resting evaluations, echocardiographic parameters were repeated during leg positive pressure (LPP). Exercise capacity was assessed by peak VO2 in all patients (left ventricular ejection fraction: 43 ± 15%). Patients with severely reduced exercise capacity (peak VO2 <14 ml/kg/min) had significantly lower stroke volume index, left ventricular global longitudinal strain and RV strain and higher filling pressure (E/e' and pulmonary arterial systolic pressure) than the remainder. Stroke volume index ( = 0.49), global longitudinal strain ( = -0.61), E/e' ( = -0.32), pulmonary arterial systolic pressure ( = -0.57), and RV strain ( = -0.66) during LPP were independently correlated to peak VO2 (all p < 0.01). RV strain during LPP was the most powerful predictor in identifying patients with severely reduced exercise capacity (cut off value: -17%; sensitivity: 81%; specificity: 88%; areas under the curve: 0.88; p < 0.001) compared with other variables including resting parameters. RV strain during pre-load augmentation correlated independently to peak VO2 and was a powerful predictor in identifying patients with severely reduced exercise capacity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2017.03.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28734918; ● Summary page in Scopus @ Elsevier: 2-s2.0-85025467938

(DOI: 10.1016/j.jcmg.2017.03.022, PubMed: 28734918, Elsevier: Scopus) Maimaituxun Gulinu, Michio Shimabukuro, Hotimah Masdan Salim, Minoru Tabata, Daisuke Yuji, Yoshihisa Morimoto, Takeshi Akasaka, Tomomi Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Takaki Sugimoto, Masashi Tanaka, Shuichiro Takanashi and Masataka Sata :
Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery,
PLoS ONE, Vol.12, No.6, e0177170, 2017.

(要約): Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG). In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005). Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.
(徳島大学機関リポジトリ): ● Metadata: 112321
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0177170
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28594865; ● Summary page in Scopus @ Elsevier: 2-s2.0-85020391442

(徳島大学機関リポジトリ: 112321, DOI: 10.1371/journal.pone.0177170, PubMed: 28594865, Elsevier: Scopus) S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, I Kishimoto, Kenji Kangawa and Masataka Sata :
Plasma brain natriuretic peptide levels are elevated in patients with cancer,
PLoS ONE, Vol.12, No.6, e0178607, 2017.

(要約): Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum C-reactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P<0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients.
(徳島大学機関リポジトリ): ● Metadata: 112318
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0178607
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28570595; ● Search Scopus @ Elsevier (PMID): 28570595; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0178607

(徳島大学機関リポジトリ: 112318, DOI: 10.1371/journal.pone.0178607, PubMed: 28570595) Salim Masdan Hotimah, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.,
Vascular Pharmacology, Vol.96-98, No.16, 19-25, 2017.

(要約): Dipeptidyl peptidase-4 (DPP-4) inhibitors have various cellular effects that are associated with vascular protection. Here, we examined whether teneligliptin alters the pro-inflammatory phenotype of perivascular adipose tissue (PVAT) and inhibits atherogenesis. Teneligliptin (60mg/kg/day) was administered orally to apolipoprotein-E-deficient (ApoE(-/-)) mice for 20weeks. Teneligliptin significantly inhibited the development of atherosclerosis in the aortic arch compared with vehicle (P<0.05), without alteration of blood glucose level or blood pressure. Histological analyses demonstrated that teneligliptin decreased lipid deposition and MCP-1 expression (P<0.05, respectively), and tended to decrease macrophage accumulation in atherosclerotic plaques. The results of quantitative RT-PCR analysis demonstrated that teneligliptin reduced the expression of inflammatory molecules such as TNF- and MCP-1 in the abdominal aorta. Furthermore, teneligliptin reduced the expression of a macrophage marker and Nox-4, a major NADPH oxidase subunit in adipocytes, in PVAT around the aortic arch. Administration of teneligliptin for 8weeks ameliorated endothelium-dependent vasodilation and reduced oxidative stress as determined by urinary 8-OHdG excretion (P<0.05) compared with vehicle. In vitro experiments demonstrated that exendin-4 (Ex-4), a GLP-1 analog, decreased the expression of inflammatory molecules in RAW264.7 cells. Also, Ex-4 decreased Nox4 expression in 3T3-L1 adipocytes. Teneligliptin inhibited atherogenesis with attenuation of the inflammatory phenotype in PVAT. A GLP-1 analog suppressed pro-inflammatory activation of macrophages and adipocytes. Suppression of the pro-inflammatory phenotype of PVAT might contribute, at least partially, to the cardioprotective effects of teneligliptin.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.vph.2017.03.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28347868; ● Summary page in Scopus @ Elsevier: 2-s2.0-85016431523

(DOI: 10.1016/j.vph.2017.03.003, PubMed: 28347868, Elsevier: Scopus) Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Longitudinal Strain to Predict Functional Recovery in Patients With Tachyarrhythmia and Reduced LVEF.,
JACC. Cardiovascular Imaging, Vol.10, No.2, 118-126, 2017.

(要約): Objectives: The aim of this study was to assess the time course of presumptive TIC and the predictors of LV functional recovery in such patients.Background: Tachycardia-induced cardiomyopathy (TIC) is a potentially reversible cardiomyopathy with effective treatment of the tachyarrhythmia. However, cases without improvement of left ventricular (LV) systolic function were found occasionally. The diagnosis of TIC can be challenging, and the role of echocardiographic imaging in the prediction of LV functional recovery is limited.Methods: LV segmental longitudinal strains (LS) were evaluated by 2-dimensional speckle tracking in 71 consecutive patients (65±16 years; 61% men) with tachyarrhythmia and reduced LV ejection fraction (EF) without any other known cardiovascular disease, and 30 age and gender matched control subjects. Relative apical LS ratio (RALSR) was defined using the equation: average apical LS / (average basal LS + average mid LS) as a marker of strain distribution.Results: Compared to control subjects, patients with tachyarrhythmia had significantly lower global LS. Improvement in LVEF within 6 months after treatment of index arrhythmia was observed in 41 patients, and LVEF did not improve in 30 patients. In univariate analysis, lower LVEF at baseline (hazard ratio: HR: 0.59 per 1SD, p=0.04) and higher RALSR (HR: 11.2 per 1SD, p <0.001) were associated with no recovery in LVEF during follow-up. In a multivariate logistic regression model, the significant predictor of LV systolic functional recovery was RALSR (HR: 22.9 per 1SD, p=0.001). A RALSR of 0.61 was sensitive (71%) and specific (90%) in differentiating LV systolic functional recovery (area under the curve: 0.88).Conclusions: The RALSR was associated with LV systolic functional recovery. This information might be useful for clinical evaluation and follow-up in patients with reduced LVEF.
(キーワード): tachycardia induced cardiomyopathy / strain imaging / functional recovery
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2016.03.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27665160; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994494325

(DOI: 10.1016/j.jcmg.2016.03.019, PubMed: 27665160, Elsevier: Scopus) K Sai, K Kajinami, H Akao, M Iwadare, R Sato-Ishida, Y Kawai, K Takeda, T Tanimoto, T Yamano, T Akasaka, T Ishida, K Hirata, K Saku, Shusuke Yagi, Takeshi Soeki, Masataka Sata, M Ueno, S Miyazaki, A Shiraki, J Oyama, K Node, K Sugamura, H Ogawa, K Kurose, K Maekawa, Y Matsuzawa, T Imatoh, R Hasegawa, Consortium Pharmacogenomics Data Science Japanese and Y Saito :
A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients.,
Drug Metabolism and Pharmacokinetics, Vol.31, No.6, 467-470, 2016.

(キーワード): Genetic polymorphism / HLA / Myopathy / Rhabdomyolysis / Statin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.dmpk.2016.09.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27839692; ● Search Scopus @ Elsevier (PMID): 27839692; ● Search Scopus @ Elsevier (DOI): 10.1016/j.dmpk.2016.09.002

(DOI: 10.1016/j.dmpk.2016.09.002, PubMed: 27839692) HM Salim, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Glycemic control with ipragliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction in streptozotocin-induced diabetic mouse.,
Frontiers in Cardiovascular Medicine, Vol.3, 43, 2016.

(要約): BACKGROUND: Endothelial dysfunction caused by increased oxidative stress is a critical initiator of macro- and micro-vascular disease development in diabetic patients. Ipragliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, offers a novel approach for the treatment of diabetes by enhancing urinary glucose excretion. The aim of this study was to examine whether ipragliflozin attenuates endothelial dysfunction in diabetic mice.METHODS: Eight-week-old male C57BL/6 mice were treated with streptozotocin (150mg/kg) by a single intraperitoneal injection to induce diabetes mellitus. At 3days of injection, ipragliflozin (3mg/kg/day) was administered via gavage for 3weeks. Vascular function was assessed by isometric tension recording. Human umbilical vein endothelial cells (HUVEC) were used for in vitro experiments. RNA and protein expression were examined by quantitative RT-PCR (qPCR) and western blot, respectively. Oxidative stress was determined by measuring urine 8-hydroxy-2'-deoxyguanosine (8-OHdG) level.RESULTS: Ipragliflozin administration significantly reduced blood glucose level (P<0.001) and attenuated the impairment of endothelial function in diabetic mice, as determined by acetylcholine-dependent vasodilation (P<0.001). Ipragliflozin did not alter metabolic parameters, such as body weight and food intake. Ipragliflozin administration ameliorated impaired phosphorylation of Akt and eNOSSer1177 in the abdominal aorta and reduced reactive oxygen species generation as determined by urinary excretion of 8-OHdG in diabetic mice. Furthermore, qPCR analyses demonstrated that ipragliflozin decreased the expression of inflammatory molecules [e.g., monocyte chemoattractant protein-1 (MCP-1) vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule (ICAM)-1] in the abdominal aorta (P<0.05). In in vitro studies, incubation with methylglyoxal, one of the advanced glycation end products, significantly impaired phosphorylation of Akt and eNOSSer1177 (P<0.01) and increased the expression of MCP-1, VCAM-1, and ICAM-1 in HUVEC.CONCLUSION: Ipragliflozin improved hyperglycemia and prevented the development of endothelial dysfunction under a hyperglycemic state, at least partially by attenuation of oxidative stress.
(キーワード): SGLT2 inhibitor / endothelial function / hyperglycemia / inflammation / oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 114485
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fcvm.2016.00043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27833913; ● Search Scopus @ Elsevier (PMID): 27833913; ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2016.00043

(徳島大学機関リポジトリ: 114485, DOI: 10.3389/fcvm.2016.00043, PubMed: 27833913) A Takashima, Shusuke Yagi, Koji Yamaguchi, S Watanabe, N Yamamoto, H Ito, M Kadota, T Hara, H Yamazaki, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Purulent pericarditis accompanying pericardial abscess induced by nocardia in an immunocompromised patient.,
Circulation Journal, Vol.80, No.11, 2409-2411, 2016.

(キーワード): Abscess / Aged, 80 and over / Echocardiography / Female / Humans / Immunocompromised Host / Nocardia / Nocardia Infections / Pericarditis / Pericardium / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-16-0531
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27628220; ● Summary page in Scopus @ Elsevier: 2-s2.0-84992462594

(DOI: 10.1253/circj.CJ-16-0531, PubMed: 27628220, Elsevier: Scopus) A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, S Nishimoto, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Taketani, Michio Shimabukuro and Masataka Sata :
Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation.,
Atherosclerosis, Vol.254, 142-150, 2016.

(要約): BACKGROUND AND AIMS: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit atherogenesis, although few studies have examined the effects of the combination of EPA and DHA on atherogenesis. The aim of this study was to investigate whether DHA has additional anti-atherosclerotic effects when combined with EPA.METHODS: Male 8-week-old apolipoprotein E-deficient (Apoe-/-) mice were fed a western-type diet supplemented with different amounts of EPA and DHA; EPA (2.5%, w/w), low-dose EPA + DHA (2.5%, w/w), or high-dose EPA + DHA (5%, w/w) for 20 weeks. The control group was fed a western-type diet containing no n-3 PUFA. Histological and gene expression analysis were performed in atherosclerotic lesions in the aorta. To address the mechanisms, RAW264.7 cells were used.RESULTS: All n-3 PUFA treatments significantly attenuated the development and destabilization of atherosclerotic plaques compared with the control. The anti-atherosclerotic effects were enhanced in the high-dose EPA + DHA group (p < 0.001), whereas the pure EPA group and low-dose EPA + DHA group showed similar results. EPA and DHA additively attenuated the expression of inflammatory molecules in RAW264.7 cells stimulated with LPS. DHA or EPA + DHA suppressed LPS-induced toll-like receptor 4 (TLR4) expression in lipid rafts on RAW264.7 cells (p < 0.05). Lipid raft disruption by methyl--cyclodextrin suppressed mRNA expression of inflammatory molecules in LPS-stimulated macrophages.CONCLUSION: n-3 PUFAs suppressed atherogenesis. DHA combined with EPA had additional anti-inflammatory effects and inhibited atherogenesis in Apoe-/- mice. The reduction of TLR4 expression in lipid rafts in macrophages by DHA might be involved in this mechanism, at least partially.
(キーワード): Atherosclerosis / Inflammation / Lipid raft / Macrophage / Toll-like receptor 4 / n-3 poly unsaturated fatty acid
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2016.10.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27744130; ● Summary page in Scopus @ Elsevier: 2-s2.0-84991678518

(DOI: 10.1016/j.atherosclerosis.2016.10.002, PubMed: 27744130, Elsevier: Scopus) M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ueno, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, Tomomi Matsuura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Response prediction and influence of tolvaptan in chronic heart failure patients considering the interaction of the renin-angiotensin-aldosterone system and arginine vasopressin.,
International Heart Journal, Vol.57, No.4, 461-465, 2016.

(要約): The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS and exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis and improves volume overload in heart failure patients, however, the predictors of tolvaptan effectiveness and the influence on the RAAS and renal function according to tolvaptan therapy are not established. We evaluated 26 chronic heart failure patients receiving therapy with 15 mg/day tolvaptan and examined their laboratory and urinary data before and after tolvaptan therapy. A response to tolvaptan was defined as a body weight decrease by more than 2 kg in a week and a urine volume increase by 500 mL/ day compared with that before tolvaptan administration. Body weight, urine volume, and brain natriuretic peptide levels significantly improved (P < 0.05), without any worsening of renal function represented by serum creatinine, sodium, and potassium. Moreover, no significant changes were observed in the plasma renin activity and plasma aldosterone concentration (PAC). In the responder group, urine osmolality before tolvaptan administration was significantly higher (P < 0.05) but declined significantly after tolvaptan administration (P < 0.05). The AVP/PAC ratio before administration was positively correlated with the efficacy of tolvaptan. Tolvaptan treatment could prevent RAAS activation in chronic heart failure patients. Moreover, monitoring the AVP/PAC ratio may be useful in predicting the tolvaptan response.
(キーワード): Adult / Aged / Aged, 80 and over / Antidiuretic Hormone Receptor Antagonists / Arginine Vasopressin / Benzazepines / Body Mass Index / Female / Heart Failure / Humans / Male / Middle Aged / Prospective Studies / Renin-Angiotensin System / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109694
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-491
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27357439; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979587993

(徳島大学機関リポジトリ: 109694, DOI: 10.1536/ihj.15-491, PubMed: 27357439, Elsevier: Scopus) Michio Shimabukuro, H Sato, Hirofumi Izaki, Daiju Fukuda, E Uematsu, Y Hirata, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Hiro-omi Kanayama, H Masuzaki and Masataka Sata :
Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.,
BioFactors, Vol.42, No.4, 397-406, 2016.

(キーワード): obesity / inflammation / gender
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/biof.1287
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27086574; ● Summary page in Scopus @ Elsevier: 2-s2.0-84982113330

(DOI: 10.1002/biof.1287, PubMed: 27086574, Elsevier: Scopus) Michio Shimabukuro, C Okawa, Hirotsugu Yamada, S Yanagi, E Uematsu, N Sugasawa, Hirotsugu Kurobe, Y Hirata, JR Kim-Kaneyama, XF Lei, S Takao, Y Tanaka, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa, H Masuzaki, M Sato and Masataka Sata :
The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: A study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.,
The Journal of Nutritional Biochemistry, Vol.35, 66-73, 2016.

(要約): Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD+Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD+E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4β-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4β-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 4β-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function.
(キーワード): Cardiac function / Cardiac hypertrophy / Epicardial fat / Obesity / Oxycholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jnutbio.2016.05.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27416363; ● Search Scopus @ Elsevier (PMID): 27416363; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jnutbio.2016.05.010

(DOI: 10.1016/j.jnutbio.2016.05.010, PubMed: 27416363) HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.,
Vascular Pharmacology, Vol.79, 16-23, 2016.

(要約): Background; The dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE-/-) mice and examined its effects on endothelial function. Methods and Results; Lina (10 mg/kg/day) was administered orally to ApoE-/- mice for 20 weeks. Lina reduced atherogenesis without the alteration of metabolic parameters including blood glucose level compared with the control (P<0.05). Results of immunohistochemistry and quantitative RT-PCR demonstrated that Lina significantly decreased inflammatory molecule expression and macrophage infiltration in atherosclerotic aorta. Lina administration to ApoE-/- mice for 9 weeks ameliorated endothelium-dependent vasodilation compared with non-treated mice. Plasma active glucagon-like peptide-1 (GLP-1) level was significantly higher in the treated group (P<0.05). Exendin-4 (Ex-4), a GLP-1 analogue, ameliorated endothelium-dependent vasodilation impaired by palmitic acid (PA) in wild-type mouse aortic segments. Ex-4 promoted phosphorylation of eNOSSer1177 and Akt which are abrogated by PA in human umbilical vein endothelial cells. In addition, Lina administration to ApoE-/- mice decreased oxidative stress as determined by urinary 8-OHdG secretion and NADPH oxidase subunit expression in the abdominal aorta.Conclusion; Lina inhibited atherogenesis in non-diabetic ApoE-/- mice. Amelioration of endothelial dysfunction associated with the reduction of oxidative stress by GLP-1 contributes to the atheroprotective effects of Lina.
(キーワード): DPP-4 inhibitor / linagliptin / GLP-1 / endothelial function / inflammation / oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 110139
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.vph.2015.08.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26277250; ● Search Scopus @ Elsevier (PMID): 26277250; ● Search Scopus @ Elsevier (DOI): 10.1016/j.vph.2015.08.011

(徳島大学機関リポジトリ: 110139, DOI: 10.1016/j.vph.2015.08.011, PubMed: 26277250) Takeshi Soeki and Masataka Sata :
Inflammatory biomarkers and atherosclerosis.,
International Heart Journal, Vol.57, No.2, 134-139, 2016.

(要約): Atherosclerosis has been regarded as a form of chronic vascular inflammation. Numerous biomarkers associated with inflammation have been identified as novel targets to monitor atherosclerosis and cardiovascular risk. C-reactive protein (CRP) is one of the most actively studied and established inflammatory biomarkers for cardiovascular events. However, CRP response is triggered by many disorders unrelated to cardiovascular disease, which interferes with the clinical application. This review describes established and traditional inflammatory biomarkers including CRP as well as novel inflammatory biomarkers reflective of local atherosclerotic inflammation. In addition, we focus on the potential usefulness of inflammatory biomarkers in developing anti-atherosclerotic therapeutic approaches.
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-346
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26973275; ● Summary page in Scopus @ Elsevier: 2-s2.0-84961564419

(DOI: 10.1536/ihj.15-346, PubMed: 26973275, Elsevier: Scopus) Takeshi Soeki, Tomomi Matsuura, Sachiko Bando, Takeshi Tobiume, Etsuko Uematsu, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
Journal of Cardiology, Vol.68, No.6, 472-477, 2016.

(要約): BACKGROUND: The underlying mechanism of atrial substrate remodeling in atrial fibrillation (AF) remains unknown. In this study, we investigated whether local and systemic levels of microRNA (miR) might be associated with the presence of AF and with left atrial (LA) substrate properties.METHODS: Blood from the periphery, pulmonary vein (PV), and left atrial appendage (LAA) was sampled from 30 patients with AF undergoing PV isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome and without AF. We measured peripheral, PV, and LAA plasma levels of miR-1, -26, -133a, -328, and -590 by reverse transcription-polymerase chain reaction. LA global contact mapping during sinus rhythm was performed before PV isolation.RESULTS: Plasma levels of miR-328 were higher in patients with AF than in control subjects. Plasma miR-328 levels were significantly higher in the LAA than in the periphery and PV in patients with AF, but not in control subjects. Plasma miR-1 levels were also higher in the LAA than in the PV in AF patients. Interestingly, LAA plasma levels of miR-328 showed a positive correlation with the LA voltage zone index (area with voltage <0.5mV divided by total LA surface area) and a weak correlation with LA volume.CONCLUSION: Local production of miR-328 in the left atrium may be involved in the process of atrial remodeling in patients with AF.
(キーワード): Atrial fibrillation / Left atrium / MicroRNA / Remodeling / Substrate
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2015.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26987792; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960969355

(DOI: 10.1016/j.jjcc.2015.12.007, PubMed: 26987792, Elsevier: Scopus) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of the addition of eicosapentaenoic acid to strong statin therapy on inflammatory cytokines and coronary plaque components assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.80, No.2, 450-460, 2016.

(要約): BACKGROUND: The effects of eicosapentaenoic acid (EPA) on coronary artery disease have been previously reported; however, those of the addition of EPA to strong statins on coronary plaque components and local inflammatory cytokines are not known.METHODSANDRESULTS: A total of 95 patients who had been treated with strong statin for at least 6 months were randomized into 2 groups: an EPA group (additional treatment with EPA at 1,800 mg/day, n=48) or a control group (no additional treatment, n=47), for 6 months. The tissue characteristics of target coronary plaque in each patient were analyzed using IB-IVUS before and after treatment. We also measured plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein.A significant reduction in lipid volume (18.5±1.3 to 15.0±1.5 mm(3), P=0.007) and a significant increase in fibrous volume (22.9±0.8 to 25.6±1.1 mm(3), P=0.01) were observed in IB-IVUS image analyses in the EPA group, but no significant changes in the plaque components in the control group. CS levels of pentraxin 3 and monocyte chemoattractant protein-1 were lower after than before treatment with EPA (3.3±2.1 to 2.6±1.2 ng/ml, 120.4±26.2 to 110.2±26.8 pg/ml, P=0.015 and P=0.008, respectively); however, there were no significant changes in those inflammatory cytokines between pre- and post-treatment in the control group.CONCLUSIONS: The addition of EPA was associated with reduced lipid volume in coronary plaques and decreased inflammatory cytokines. (Circ J 2016; 80: 450-460).
(キーワード): Coronary plaque / Eicosapentaenoic acid / Inflammatory cytokines / Integrated backscatter intravascular ultrasound / Strong statins
(徳島大学機関リポジトリ): ● Metadata: 109653
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0813
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26667367; ● Summary page in Scopus @ Elsevier: 2-s2.0-84955453337

(徳島大学機関リポジトリ: 109653, DOI: 10.1253/circj.CJ-15-0813, PubMed: 26667367, Elsevier: Scopus) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Eri Takagi, Tamotsu Kanbara, Hirohisa Ogawa, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Vegetation in the coronary sinus that concealed the presence of a coronary arteriovenous fistula in a patient with infectious endocarditis.,
International Journal of Cardiology, Vol.207, 266-268, 2016.

(キーワード): Coronary sinus / Fistula / Infectious endocarditis / Vegetation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2016.01.057
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26808990; ● Summary page in Scopus @ Elsevier: 2-s2.0-84958019532

(DOI: 10.1016/j.ijcard.2016.01.057, PubMed: 26808990, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando, Tomoya Hara, Sachiko Nishimoto, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.,
Nutrition Journal, Vol.14, No.1, 111, 2015.

(要約): BACKGROUND: The hospitalization rate for acute coronary syndrome (ACS) for people aged 50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unknown whether reduced serum levels of n-3 PUFAs is also a risk factor for ACS in patients aged 50 years.METHODS AND RESULTS: We retrospectively reviewed 102 (male/ female 73/29) Japanese ACS patients whose serum levels of EPA/arachidonic acid (AA) and DHA/AA were evaluated on admission. The EPA/AA ratio was the lowest in patients aged 50 compared to patients aged 51-74 and 75. Pearson correlation analysis showed that early ACS onset was associated with low EPA/AA and DHA/AA ratios, and multiple regression analysis determined that decreased ratios of EPA/AA and DHA/AA, and male sex, current smoker status, increased body mass index and triglyceride levels, independently correlated with early ACS onset. Conversely, low-density and high-density lipoproteins, glycated hemoglobin, and hypertension did not correlate with early ACS onset. Subgroup analyses of male patients revealed that decreased ratios of EPA/AA and DHA/AA independently correlated with early ACS onset.CONCLUSION: Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12937-015-0102-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26514181; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945959581

(DOI: 10.1186/s12937-015-0102-4, PubMed: 26514181, Elsevier: Scopus) S Bando, Daiju Fukuda, Takeshi Soeki, S Nishimoto, E Uematsu, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.,
Atherosclerosis, Vol.242, No.2, 407-414, 2015.

(要約): ObjectivesThe promotion of adipose tissue inflammation by lifestyle-related diseases such as obesity and diabetes accelerates atherogenesis; however, the underlying mechanisms remain incompletely understood. Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome contributes to chronic inflammation in adipose tissue. Here, we investigated the link between NLRP3 expression in subcutaneous adipose tissue (SAT) and the severity of coronary atherosclerosis.Methods and resultsSAT was obtained from 72 patients who underwent heart device implantation and coronary angiography. Expression of NLRP3 inflammasome-related molecules (NLRP3, IL-1 and IL-18) in SAT were evaluated by quantitative RT-PCR. Laboratory markers related to lifestyle-related diseases were measured. Patients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3. Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. The expression of NLRP3 in SAT correlated negatively with serum adiponectin level (r = 0.23, P < 0.05). Patients with coronary artery disease showed higher NLRP3 expression than patients without significant stenosis (P < 0.01). Furthermore, the expression of NLRP3 in SAT correlated positively with the severity of coronary atherosclerosis as determined by Gensini score (r = 0.47, P < 0.0001) or SYNTAX score (r = 0.55, P < 0.0001). Multiple regression analysis revealed that the expression of NLRP3 in SAT remains as an independent predictors for the severity of coronary atherosclerosis.ConclusionsThe expression of NLRP3 in SAT, which is affected by lifestyle-related diseases, is associated with the severity of coronary atherosclerosis. Our results suggest that NLRP3 inflammasome in SAT may have a role in atherogenesis.
(キーワード): Atherosclerosis / Adipose tissue / Inflammation / NLRP3 inflammasome / Lifestyle-related disease
(徳島大学機関リポジトリ): ● Metadata: 109532
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.07.043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26282945; ● Search Scopus @ Elsevier (PMID): 26282945; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2015.07.043

(徳島大学機関リポジトリ: 109532, DOI: 10.1016/j.atherosclerosis.2015.07.043, PubMed: 26282945) Hara Tomoya, Daiju Fukuda, Tanaka Kimie, Higashikuni Yasutomi, Hirata Yoichiro, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.,
Atherosclerosis, Vol.242, No.2, 639-646, 2015.

(要約): OBJECTIVE: Activated factor X (FXa) plays a key role in the coagulation cascade, whereas accumulating evidence suggests that it also contributes to the pathophysiology of chronic inflammation on the vasculature. In this study, we assessed the hypothesis that rivaroxaban (Riv), a direct FXa inhibitor, inhibits atherogenesis by reducing macrophage activation.METHODS AND RESULTS: Expression levels of PAR-1 and PAR-2, receptors for FXa, increased in the aorta of apolipoprotein E-deficient (ApoE(-/-)) mice compared with wild-type mice (P < 0.01, P < 0.05, respectively). Administration of Riv (5 mg/kg/day) for 20 weeks to 8-week-old ApoE(-/-) mice reduced atherosclerotic lesion progression in the aortic arch as determined by en-face Sudan IV staining compared with the non-treated group (P < 0.05) without alteration of plasma lipid levels and blood pressure. Histological analyses demonstrated that Riv significantly decreased lipid deposition, collagen loss, macrophage accumulation and matrix metallopeptidase-9 (MMP-9) expression in atherosclerotic plaques in the aortic root. Quantitative RT-PCR analyses using abdominal aorta revealed that Riv significantly reduced mRNA expression of inflammatory molecules, such as MMP-9, tumor necrosis factor- (TNF-). In vitro experiments using mouse peritoneal macrophages or murine macrophage cell line RAW264.7 demonstrated that FXa increased mRNA expression of inflammatory molecules (e.g., interleukin (IL)-1 and TNF-), which was blocked in the presence of Riv.CONCLUSIONS: Riv attenuates atherosclerotic plaque progression and destabilization in ApoE(-/-) mice, at least in part by inhibiting pro-inflammatory activation of macrophages. These results indicate that Riv may be particularly beneficial for the management of atherosclerotic diseases, in addition to its antithrombotic activity.
(キーワード): Activated factor X / 動脈硬化 (atherosclerosis) / Coagulation / 炎症 (inflammation) / Macrophages / Rivaroxaban
(徳島大学機関リポジトリ): ● Metadata: 109485
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2015.03.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817329; ● Summary page in Scopus @ Elsevier: 2-s2.0-84941742835

(徳島大学機関リポジトリ: 109485, DOI: 10.1016/j.atherosclerosis.2015.03.023, PubMed: 25817329, Elsevier: Scopus) Anna Tani, S Yamamoto, Masahiko Maegawa, Koutaro Kunimi, Sumika Matsui, Kaoru Keyama, Takeshi Katou, Hirokazu Uemura, Akira Kuwahara, Toshiya Matsuzaki, Toshiyuki Yasui, M Kamada, Takeshi Soeki, Masataka Sata and Minoru Irahara :
Arterial stiffness is increased in young women with endometriosis.,
Journal of Obstetrics and Gynaecology, Vol.35, No.7, 711-715, 2015.

(要約): Endometriosis is a chronic gynaecological disorder that is accompanied by inflammation and oxidative stress. Atherosclerosis has a long subclinical progression in arteries of children and young adults decades before overt clinical manifestations of the disease. In this study, we determined arterial stiffness by measuring brachial-ankle pulse wave velocity (baPWV) in women with endometriosis to assess the presence of subclinical atherosclerosis. We also measured markers of inflammation and oxidative stress in women with endometriosis. baPWV in women with endometriosis aged over 30 years was significantly higher than that in women without endometriosis aged over 30 years (p < 0.05), but not in women aged less than 30. Serum high-sensitivity C-reactive protein level in women with endometriosis was significantly higher than that in controls (p < 0.05). Young women with endometriosis show significantly increased arterial stiffness, suggesting that women with endometriosis need to be cautious of the future onset of atherosclerosis.
(キーワード): arterial stiffness / endometriosis / hs CRP / subclinical inflammation / young women
(出版サイトへのリンク): ● Publication site (DOI): 10.3109/01443615.2014.992871
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25543526; ● Summary page in Scopus @ Elsevier: 2-s2.0-84944158077

(DOI: 10.3109/01443615.2014.992871, PubMed: 25543526, Elsevier: Scopus) Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Takashi Iwase, Susumu Nishio, Shuji Hayashi, Mika Bando, Rie Amano, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Measuring Epicardial Adipose Tissue Thickness with Echocardiography Using a High-Frequency Linear Probe in Patients with Coronary Artery Disease.,
Journal of the American Society of Echocardiography, Vol.28, No.10, 1240-1246.e1, 2015.

(要約): The relationship between epicardial adipose tissue (EAT) and coronary artery disease (CAD) has recently attracted a great deal of attention in the medical community. The objective of this study was to determine whether measuring EAT thickness in the anterior interventricular groove (AIG) using echocardiography is feasible and whether this index can be a marker of CAD. A total of 311 patients (mean age, 67 ± 11 years; 208 men) who underwent coronary angiography between December 2011 and December 2013 were prospectively enrolled. EAT-AIG thickness and EAT thickness on the free wall of the right ventricle (RV) were measured in systole using a high-frequency linear probe. Seventy-one patients who underwent multidetector-row computed tomography were enrolled to validate the method for measuring EAT thickness using echocardiography. Subjects were divided into two groups, those with and without significant coronary stenosis, on the basis of findings on coronary angiography (≥ 75% luminal narrowing). EAT-AIG thickness measured using echocardiography was validated by computed tomography. EAT-AIG thickness was strongly correlated with EAT volume (r = 0.714, P < .001). The CAD group had thicker EAT-AIG than the non-CAD group (8.3 ± 3.0 vs 6.3 ± 2.5 mm, P < .001). EAT-RV thickness was greater in the CAD group than in the non-CAD group (5.0 ± 2.1 vs 4.4 ± 2.3 mm, P = .009) as well. The area under the curve on receiver operating characteristic curve analysis of EAT-AIG thickness for predicting CAD was 0.704, which was higher than the EAT-RV thickness. Measuring EAT thickness using echocardiography with a high-frequency linear probe was validated with computed tomography. EAT-AIG was thicker in the CAD group than in the non-CAD group, as was EAT-RV thickness. This noninvasive index may have potential as a diagnostic marker for predicting coronary atherosclerosis.
(徳島大学機関リポジトリ): ● Metadata: 109714
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2015.07.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26275751; ● Summary page in Scopus @ Elsevier: 2-s2.0-84944180106

(徳島大学機関リポジトリ: 109714, DOI: 10.1016/j.echo.2015.07.006, PubMed: 26275751, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Masashi Akaike, Daiju Fukuda, HM Salim, Masayoshi Ishida, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Toshio Matsumoto and Masataka Sata :
Predictive factors for efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus.,
Diabetes & Metabolism Journal, Vol.39, No.4, 342-347, 2015.

(要約): BACKGROUND: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment.METHODS: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3±35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively.RESULTS: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167±63 to 151±49 mg/dL (P<0.01), and from 7.5%±1.3% to 6.9%±0.9% (P<0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease.CONCLUSION: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.
(キーワード): Coronary artery disease / 糖尿病 (diabetes mellitus) / Dipeptidyl-peptidase IV inhibitors / Obese / Predictive factors
(出版サイトへのリンク): ● Publication site (DOI): 10.4093/dmj.2015.39.4.342
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26301197; ● Summary page in Scopus @ Elsevier: 2-s2.0-84939780057

(DOI: 10.4093/dmj.2015.39.4.342, PubMed: 26301197, Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi and Masataka Sata :
Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease.,
Journal of the American College of Cardiology, Vol.66, No.4, 376-384, 2015.

(要約): BACKGROUND: Early detection of pulmonary hypertension (PH) in connective tissue disease (CTD) is crucial to ensuring that patients receive timely treatment for this progressive disease. Exercise stress tests have been used to screen patients in an attempt to identify early-stage PH. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (Q) responses as having the potential to assess the disease state.OBJECTIVES: This study hypothesized that pulmonary circulation pressure-flow relationships obtained by 6-min walk (6MW) stress echocardiography would better delineate differential progression of PH and predict development of PH during follow-up.METHODS: We prospectively performed 6MW stress echocardiographic studies in 78 CTD patients (age 58 ± 12 years; 9% male) at baseline and follow-up. All patients underwent yearly echocardiographic follow-up studies for up to 5 years.RESULTS: During a median period of 32 months (range: 15 to 62 months), 16 patients reached the clinical endpoint of development of PH and none died during follow-up. PH was confirmed by right heart catheterization in all 16 patients (mPAP 25 mm Hg and pulmonary capillary wedge pressure 15 mm Hg). In a Cox proportional-hazards survival model, 6MW distance (hazard ratio [HR]: 0.99; p = 0.010), early diastolic tricuspid annulus motion velocity (HR: 0.79; p = 0.025), and mPAP/Q by 6MW stress (HR: 1.10; p = 0.005) were associated with development of PH. In sequential Cox models, a model on the basis of 6MW distance (chi-square, 6.6) was improved by mPAP/Q (chi-square: 14.4; p = 0.019). Using a receiver-operating characteristic curve, we found that the best cutoff value of mPAP/Q for predicting development of pulmonary hypertension was >3.3 mm Hg/l/min.CONCLUSIONS: The 6MW stress echocardiography noninvasively provides an incremental prognostic value of PH development in CTD. This is a single-center prospective cohort study. Larger multicenter studies are warranted to confirm this result.
(キーワード): lupus erythematosus / mixed connective tissue disease / pulmonary circulation / systemic scleroderma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2015.05.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26205595; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937681606

(DOI: 10.1016/j.jacc.2015.05.032, PubMed: 26205595, Elsevier: Scopus) Mika Bando, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Rie Amano, Rina Tamai, Yuta Torii, Yukina Hirata, Susumu Nishio, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of carotid plaque tissue characteristics in patients with acute coronary syndrome or stable angina pectoris: assessment by iPlaque, transcutaneous carotid ultrasonography with integrated backscatter analysis.,
Cardiovascular Ultrasound, Vol.13, No.1, 34, 2015.

(要約): BACKGROUND: The association of the tissue characteristics of carotid plaques with coronary artery disease has attracted interest. The present study compared the tissue characteristics of carotid plaques in patients with acute coronary syndrome (ACS) with those in patients with stable angina pectoris (SAP) using the iPlaque system, which is based on ultrasound integrated backscatter.METHODS AND RESULTS: Carotid ultrasound examinations were performed in 26 patients with ACS, and 38 age- and gender-matched patients with SAP. Neither plaque area nor maximal intima-media thickness differed significantly between the two groups. However, the average integrated backscatter value within the plaque was greater in the ACS patients than in the SAP patients. iPlaque analysis revealed that the percentage blue area (lipid pool) was greater in the ACS patients than in the SAP patients (43.4±11.2 vs 18.3±10.3 %, p<0.0001), and that the percentage green area (fibrosis) was lower in the ACS than in the SAP patients (7.5±7.5 % vs 20.7±11.7 %, p<0.0001).CONCLUSIONS: The lipid component of carotid plaques is greater in ACS patients than in SAP patients. Our iPlaque system provides a useful and feasible method for the tissue characterization of carotid plaques in the clinical setting.
(キーワード): Carotid arteries / Plaque vulnerability / 超音波 (ultrasound) / Acute coronary syndrome (ACS)
(徳島大学機関リポジトリ): ● Metadata: 109520
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12947-015-0031-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26209244; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937791819

(徳島大学機関リポジトリ: 109520, DOI: 10.1186/s12947-015-0031-6, PubMed: 26209244, Elsevier: Scopus) Hiromu Yamazaki, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Atsunori Kitaoka, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound.,
Circulation Journal, Vol.79, No.8, 1773-1779, 2015.

(要約): BACKGROUND: Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS).MethodsandResults:IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=-0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=-0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=-0.305, P=0.04) independently of potentially confounding coronary risk factors.CONCLUSIONS: Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging. (Circ J 2015; 79: 1773-1779).
(キーワード): Coronary plaque / Indoxyl sulfate / Integrated backscatter intravascular ultrasound
(徳島大学機関リポジトリ): ● Metadata: 109533
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-15-0019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25971408; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937904061

(徳島大学機関リポジトリ: 109533, DOI: 10.1253/circj.CJ-15-0019, PubMed: 25971408, Elsevier: Scopus) Kenya Kusunose, Junko Hotsuchi, Y Takagawa, S Nishio, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial imaging changes during treatment of immunoglobulin G4-related disease with multiple pseudotumors.,
Circulation, Vol.131, No.21, 1882-1883, 2015.

(キーワード): Aged, 80 and over / Antibodies, Anti-Idiotypic / Arteries / Cardiomegaly / Coronary Aneurysm / Eyelid Diseases / Fluorodeoxyglucose F18 / Humans / Immunoglobulin G / Male / Paraproteinemias / Plasma Cells / Positron-Emission Tomography / Radiopharmaceuticals / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.115.015638
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26015466; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936080389

(DOI: 10.1161/CIRCULATIONAHA.115.015638, PubMed: 26015466, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Tomoya Hara, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.5, 447-454, 2015.

(要約): AIM: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.METHODS: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).RESULTS: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P0.01) and age was a negative (P0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.CONCLUSIONS: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
(キーワード): Flow-mediated dilation / n-3 polyunsaturated fatty acids / Docosahexaenoic acid
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.26914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25342567; ● CiNii @ 国立情報学研究所 (CRID): 1390282679408260352; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929412906

(DOI: 10.5551/jat.26914, PubMed: 25342567, CiNii: 1390282679408260352, Elsevier: Scopus) Toshiyuki Niki, Takeshi Soeki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Elevated concentration of interferon-inducible protein of 10 kD (IP-10) is associated with coronary atherosclerosis.,
International Heart Journal, Vol.56, No.3, 269-272, 2015.

(要約): Several studies have shown that various chemokines are more highly expressed in atherosclerotic plaques than in normal vessel walls. In the present study, we investigated the relationship between coronary atherosclerosis and noteworthy chemokines, including interferon-inducible protein of 10 kD (IP-10); monocyte chemoattractant protein 1 (MCP-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and high-sensitivity C-reactive protein (hsCRP), an established marker of atherosclerotic disease. We studied 28 patients who underwent coronary angiography because of suspected coronary artery disease (CAD). CAD was defined as stenosis of more than 50% of the vessel diameter on coronary angiograms. Blood samples were obtained both from the aorta and the coronary sinus (CS) just before coronary angiography. Relative to CAD (-) patients, those who were CAD (+) tended to have higher plasma concentrations of IP-10 in the aorta, as well as significantly higher transcoronary concentration gradients of circulating IP-10. There were no significant differences between the two groups in aortic plasma concentrations or transcoronary concentration gradients of MCP-1, RANTES, and hsCRP. Furthermore, both the aortic plasma concentrations and transcoronary concentration gradients of IP-10 correlated with the Gensini score (r = 0.58 and r = 0.63, respectively, P < 0.01), while the plasma MCP-1, RANTES, and serum hsCRP concentrations did not. This study suggests that IP-10 is a good surrogate marker of coronary atherosclerosis.
(キーワード): Coronary artery disease / Coronary circulation / Chemokine
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25902883; ● Search Scopus @ Elsevier (PMID): 25902883; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-300

(DOI: 10.1536/ihj.14-300, PubMed: 25902883) Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, E Uematsu, S Bando, T Matsuura, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma microRNA-100 is associated with coronary plaque vulnerability.,
Circulation Journal, Vol.79, No.2, 413-418, 2015.

(要約): BACKGROUND: Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.MethodsandResults:Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=-0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=-0.56, P<0.01).CONCLUSIONS: miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (Circ J 2015; 79: 413-418).
(キーワード): Coronary artery disease / Coronary circulation / Intravascular ultrasound / MicroRNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0958
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25519160; ● CiNii @ 国立情報学研究所 (CRID): 1390001205108464000; ● Summary page in Scopus @ Elsevier: 2-s2.0-84928251309

(DOI: 10.1253/circj.CJ-14-0958, PubMed: 25519160, CiNii: 1390001205108464000, Elsevier: Scopus) S Kimura, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Takashi Iwase, K Nishikawa, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike, Natsuo Yasui and Masataka Sata :
Impact of supervised cardiac rehabilitation on urinary albumin excretion in patients with cardiovascular disease.,
International Heart Journal, Vol.56, No.1, 105-109, 2015.

(要約): Urinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m(2) who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m(2) to 67 ± 17 mL/minute/1.73 m(2), P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients.
(キーワード): Cardiac rehabilitation / Renal function / Cardiovascular disease
(徳島大学機関リポジトリ): ● Metadata: 109367
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-161
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25742947; ● Search Scopus @ Elsevier (PMID): 25742947; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-161

(徳島大学機関リポジトリ: 109367, DOI: 10.1536/ihj.14-161, PubMed: 25742947) Shusuke Yagi, A Takashima, M Mitsugi, T Wada, Junko Hotsuchi, Ken-ichi Aihara, T Hara, Masayoshi Ishida, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.,
Therapeutics and Clinical Risk Management, Vol.11, 83-88, 2015.

(要約): Background: Hypertension is one of the major risk factors for cardiovascular and cerebrovascular disease and mortality. Patients who receive insufficient doses of antihypertensive agents or who are poorly adherent to multidrug treatment regimens often fail to achieve adequate blood pressure (BP) control. The aim of this study was to determine the efficacy of an angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) combination tablet containing a regular dose of irbesartan (100 mg) and a high dose of amlodipine (10 mg) with regard to lowering BP and other risk factors for cardiovascular disease.Methods: We retrospectively evaluated data from 68 patients with essential hypertension whose treatment regimen was changed either from combination treatment with an independent ARB and a low-dose or regular-dose CCB or from a combination tablet of ARB and a low-dose or regular-dose CCB to a combination tablet containing amlodipine 10 mg and irbesartan 100 mg, because of incomplete BP control. Previous treatments did not include irbesartan as the ARB.Results: The combination tablet decreased systolic and diastolic BP. In addition, it significantly decreased serum uric acid, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels, independent of the BP-lowering effect. Treatment with the combination tablet did not affect serum triglycerides, plasma glucose, glycated hemoglobin, serum potassium or creatinine levels, or the urinary albumin excretion rate.Conclusion: The combination tablet containing amlodipine 10 mg and irbesartan 100 mg had a greater BP-lowering effect than an ARB and a low-dose or regular-dose CCB. In addition, the combination tablet had more favorable effects on serum uric acid, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels in patients with hypertension.
(キーワード): blood pressure / combination tablet / uric acid / low-density lipoprotein cholesterol / high-density lipoprotein cholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/TCRM.S72299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25624765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921260560

(DOI: 10.2147/TCRM.S72299, PubMed: 25624765, Elsevier: Scopus) Shusuke Yagi, T Hara, R Ueno, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.,
Nutrition Journal, Vol.13, No.1, 112, 2014.

(要約): BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD.METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated.RESULTS: Pearson correlation analysis showed that EPA (R =0.25, P <0.01), EPA/AA ratio (R =0.22, P =0.01), and left ventricular ejection fraction (R =0.15, P =0.04) were positively associated with MMSE score, and that age (R = -0.20, P <0.01) and brain natriuretic peptide levels (R = -0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded.CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients.
(キーワード): Aged / Arachidonic Acid / Cognition / Cognition Disorders / Coronary Disease / Eicosapentaenoic Acid / Fatty Acids, Omega-3 / Female / Humans / Japan / Male / Middle Aged / Retrospective Studies / Risk Factors / Stroke Volume
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2891-13-112
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25471307; ● Summary page in Scopus @ Elsevier: 2-s2.0-84926465688

(DOI: 10.1186/1475-2891-13-112, PubMed: 25471307, Elsevier: Scopus) Takeshi Soeki, Kunihiko Koshiba, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kazuo Minakuchi, I Kishimoto, Kenji Kangawa and Masataka Sata :
Effect of ghrelin on autonomic activity in healthy volunteers.,
Peptides, Vol.62, 1-5, 2014.

(要約): Ghrelin is a novel growth hormone (GH)-releasing peptide originally isolated from the stomach. Recently, we have shown that ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. In the present study, we evaluated the effect of ghrelin on autonomic nerve activity in healthy human subjects. An intravenous bolus of human synthetic ghrelin (10g/kg) was administered to 10 healthy men (mean age, 33 years). Holter monitoring assessment was performed before and during 2h after the ghrelin therapy. The standard deviation of normal RR intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent RR intervals (rMSSD), high-frequency power (HF), and low-frequency power (LF) were analyzed. Blood samples were also obtained before and after the therapy. A single administration of ghrelin decreased both heart rate and blood pressure. Interestingly, ghrelin significantly decreased the LF and LF/HF ratio of heart rate variability and increased the SDNN, rMSSD, and HF. Ghrelin also elicited a marked increase in circulating GH, but not insulin-like growth factor-1. These data suggest that ghrelin might suppress cardiac sympathetic nerve activity and stimulate cardiac parasympathetic nerve activity.
(キーワード): Ghrelin / Autonomic nerve activity / Heart rate variability / Electrocardiography / Hemodynamics
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.peptides.2014.09.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25265271; ● Search Scopus @ Elsevier (PMID): 25265271; ● Search Scopus @ Elsevier (DOI): 10.1016/j.peptides.2014.09.015

(DOI: 10.1016/j.peptides.2014.09.015, PubMed: 25265271) Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, S Nishimoto, C Kozuka, Daiju Fukuda, Takeshi Soeki, H Masuzaki, M Tsutsui and Masataka Sata :
MicroRNA-378 regulates adiponectin expression in adipose tissue: A new plausible mechanism.,
PLoS ONE, Vol.9, No.11, e111537, 2014.

(要約): AIMS: Mechanisms regulating adiponectin expression have not been fully clarified. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, are involved in biological processes, including obesity and insulin resistance. We evaluated whether the miRNA-378 pathway is involved in regulating adiponectin expression.METHODS AND RESULTS: First, we determined a putative target site for miRNA-378 in the 3 prime untranslated region (3'UTR) of the adiponectin gene by in silico analysis. The levels of adiponectin mRNA and protein were decreased in 3T3-L1 cells overexpressing the mimic of miRNA-378. Luminescence activity in HEK293T cells expressing a renilla-luciferase-adiponectin-3'UTR sequence was inhibited by overexpressing the mimic of miRNA-378, and the decrease was reversed by adding the inhibitor of miRNA-378. Moreover, we confirmed the inhibitory effects of the mimic were cancelled in a deleted mutant of the miR-378 3'-UTR binding site. Addition of tumor necrosis factor- (TNF) led a upregulation of miR-378 and downregulation of adiponectin at mRNA and protein levels in 3T3-L1 cells. Level of miR-378 was higher and mRNA level of adiponectin was lower in diabetic ob/ob mice than those of normal C57BL/6 mice and levels of miR378 and adiponectin were negatively well correlated (r=-0.624, p=0.004).CONCLUSIONS: We found that levels of miRNA-378 could modulate adiponectin expression via the 3'UTR sequence-binding site. Our findings warrant further investigations into the role of miRNAs in regulating the adiponectin expression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0111537
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25379946; ● Search Scopus @ Elsevier (PMID): 25379946; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0111537

(DOI: 10.1371/journal.pone.0111537, PubMed: 25379946) Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, Hiroyasu Oeduka, Kenya Kusunose, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients.,
Circulation Journal, Vol.78, No.1, 240-247, 2014.

(要約): Telmisartan has unique pleiotropic effects in addition to renin-angiotensin system (RAS)-inhibition effects. The aim of this study was to evaluate the effects of telmisartan on the coronary plaque component and local inflammatory cytokines. A total of 50 patients with hypertension were randomized to 2 groups: the telmisartan group (additional treatment with telmisartan 80mg/day, n=25) or the control group (additional treatment with other anti-hypertensive drugs except RAS blockers, n=25) for 6 months. Tissue characteristics of target coronary plaque were analyzed using integrated backscatter intravascular ultrasound (IB-IVUS) before and after treatment. Plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein were also measured. Significant increases in fibrous volume (51.2±10.4 to 58.3±7.7%, P=0.03) and reductions in lipid volume (38.4±12.4 to 32.8±9.7%, P=0.03) were observed on IB in the telmisartan group, while there were no significant changes in the plaque component in the control group. CS levels of inflammatory cytokines (matrix metalloproteinase [MMP]3, tumor necrosis factor-, high-sensitivity C-reactive protein and MMP9) were lower after than before treatment in the only telmisartan group (7.7±6.1 to 5.5±4.9ng/ml, 3.1±1.9 to 2.3±2.0pg/ml, 5.6±6.0 to 2.2±2.4mg/L, 36.1±39.3 to 19.9±27.5ng/ml, P=0.02, P=0.03, P=0.04, P=0.07, respectively). Decreased local inflammatory response and plaque stabilization on IB imaging were observed after 6 months of telmisartan treatment. These findings might be associated with local anti-inflammatory and anti-arteriosclerotic effects of telmisartan.
(キーワード): Coronary plaque / Inflammatory cytokine / Integrated backscatter intravascular ultrasound / Telmisartan
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-0741
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24189463; ● CiNii @ 国立情報学研究所 (CRID): 1390282680085613824; ● Summary page in Scopus @ Elsevier: 2-s2.0-84891099318

(DOI: 10.1253/circj.CJ-13-0741, PubMed: 24189463, CiNii: 1390282680085613824, Elsevier: Scopus) A Takashima, Takayuki Ise, Shusuke Yagi, Takashi Iwase, S Kimura, Yuka Ueda, K Nishikawa, A Ishii, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike and Masataka Sata :
Cardiac rehabilitation reduces serum levels of oxidized low-density lipoprotein.,
Circulation Journal, Vol.78, No.11, 2682-2687, 2014.

(要約): BACKGROUND: Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.MethodsandResults:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (VO2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak VO2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. VO2(peak VO2after CR-peak VO2before CR) was negatively associated with MDA-LDL (MDA-LDL after CR-MDA-LDL before CR) (R(2)=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.CONCLUSIONS: CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682-2687).
(キーワード): Cardiac rehabilitation / Lipoproteins / Oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 109368
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0532
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25241889; ● Search Scopus @ Elsevier (PMID): 25241889; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-14-0532

(徳島大学機関リポジトリ: 109368, DOI: 10.1253/circj.CJ-14-0532, PubMed: 25241889) Takeshi Soeki, S Bando, E Uematsu, T Matsuura, Toshiyuki Niki, Takayuki Ise, Kenya Kusunose, Junko Hotsuchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pentraxin 3 is a local inflammatory marker in atrial fibrillation.,
Heart and Vessels, Vol.29, No.5, 653-658, 2014.

(要約): Increasing evidence indicates that inflammation contributes to the pathogenesis of atrial fibrillation (AF). Pentraxin 3 (PTX3) is produced abundantly in local inflammatory lesions while C-reactive protein (CRP) is produced mainly in the liver. In this study, we investigated whether a local level of PTX3 might be a sensitive marker for the local inflammation of AF. Blood from the periphery and left atrial appendage (LAA) was sampled from 23 patients with AF undergoing pulmonary vein isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome. We measured peripheral and LAA plasma concentrations of CRP, interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and PTX3. Plasma PTX3 concentrations in both locations were higher in patients with AF than in control subjects. PTX3 concentrations were significantly higher in the LAA than the periphery in patients with AF (3.7 ± 1.4 vs 3.3 ± 1.2 ng/ml, P < 0.01), but not in control subjects (2.4 ± 0.5 vs 2.4 ± 0.5 ng/ml, not significant). Patients and controls showed no significant differences in CRP, IL-6, or TNF- concentrations between the periphery and LAA. Interestingly, there was a significant positive correlation between LAA plasma concentrations of PTX3 and left atrial volume (r = 0.55, P < 0.01). These data demonstrate that Local PTX3 production in the left atrium might reflect the local inflammation of AF.
(キーワード): Pentraxin 3 / Atrial fibrillation / 炎症 (inflammation)
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0400-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23979265; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929517476

(DOI: 10.1007/s00380-013-0400-8, PubMed: 23979265, Elsevier: Scopus) Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Junko Hotsuchi, S Hayashi, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pre-load stress echocardiography for predicting the prognosis in mild heart failure.,
JACC. Cardiovascular Imaging, Vol.7, No.7, 641-649, 2014.

(キーワード): Doppler echocardiography / heart failure / leg-positive pressure / stress echocardiography / survival
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2014.04.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24954460; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904576445

(DOI: 10.1016/j.jcmg.2014.04.009, PubMed: 24954460, Elsevier: Scopus) S Bando, Takeshi Soeki, T Matsuura, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, T Aiba, W Shimizu and Masataka Sata :
Congenital long QT syndrome with compound mutations in the KCNH2 gene.,
Heart and Vessels, Vol.29, No.4, 554-559, 2014.

(要約): Congenital long QT syndrome is a genetic disorder encompassing a family of mutations that can lead to aberrant ventricular electrical activity. We report on two brothers with long QT syndrome caused by compound mutations in the KCNH2 gene inherited from parents who had no prolonged QT interval on electrocardiography. The proband had syncope, and his elder brother suffered from ventricular fibrillation. Genetic testing revealed that both brothers had multiple mutations in the KCNH2 gene, including a missense mutation of C1474T (exon 6) as well as a frameshift/nonsense mutation, resulting from the insertion of 25 nucleotides, which caused an altered amino acid sequence beginning at codon 302 and a premature termination codon (i.e., TAG) at codon 339 (exon 4). Family genetic screening found that their father had the same frameshift mutation, and their mother and sister had the same missense mutation, in the KCNH2 gene. However, these other family members were asymptomatic, with normal QT intervals on electrocardiography. These results suggest that compound mutations in the KCNH2 gene inherited independently from the parents made the phenotypes of their sons more severe.
(キーワード): KCNH2 gene / Long QT syndrome / Compound mutation / Missense mutation / Frameshift mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0406-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24057343; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904036858

(DOI: 10.1007/s00380-013-0406-2, PubMed: 24057343, Elsevier: Scopus) S Hayashi, Hirotsugu Yamada, Mika Bando, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiaki Tamaki and Masataka Sata :
Augmentation Index does not Reflect the Risk of Coronary Artery Disease in Elderly Patients.,
Circulation Journal, Vol.78, No.5, 1176-1182, 2014.

(要約): BACKGROUND: Augmentation index (AI) has been used as a clinical index of arterial stiffness and has been reported to be an independent predictor of cardiovascular events, but some investigators have reported that AI is not a useful marker to identify coronary artery disease (CAD) in elderly patients. The majority of CAD patients are elderly people, therefore the aim of this study was to examine whether AI is a useful marker to identify the risk of CAD.METHODS AND RESULTS: A total of 120 patients (69±10 years of age; 83 male) who underwent cardiac catheterization for suspected CAD were enrolled. Invasive central blood pressure (BP) was measured using a fluid-filled catheter. Non-invasive AI was calculated by the SphygmoCor (AtCor Medical) system at the end of catheterization. Subjects consisted of 99 patients with CAD and 21 patients without CAD. There was no significant difference in AI between the CAD and the non-CAD groups (24±10 vs. 24±14%). Non-invasive systolic central BP was lower than the invasive systolic central BP (115±18 vs. 130±23 mmHg, P<0.001) in all patients. Non-invasive diastolic central BP was greater than the invasive diastolic central BP (67±10 vs. 63±10 mmHg, P<0.001).CONCLUSIONS: In elderly patients, AI may not be a useful marker to identify CAD
(キーワード): Arterial stiffness / Augmentation index / Central blood pressure / Coronary artery disease
(徳島大学機関リポジトリ): ● Metadata: 106070
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-1422
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24562676; ● CiNii @ 国立情報学研究所 (CRID): 1390001205107150592; ● Summary page in Scopus @ Elsevier: 2-s2.0-84899659435

(徳島大学機関リポジトリ: 106070, DOI: 10.1253/circj.CJ-13-1422, PubMed: 24562676, CiNii: 1390001205107150592, Elsevier: Scopus) Takayuki Ise, Takashi Iwase, S Masuda, Shusuke Yagi, Masashi Akaike, S Nishio, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute pulmonary thromboembolism from deep vein thrombosis induced by trauma to the popliteal vein with a tennis racket.,
Journal of Cardiology Cases, Vol.9, No.4, 162-164, 2014.

(要約): Acute pulmonary thromboembolism (PTE) is mainly caused by deep vein thrombosis (DVT) and sometimes leads to a fatal outcome. Few cases of sport-related lower extremity DVT, involving direct external trauma, have been reported. A 58-year-old man, without any risk factors for thromboembolism suffered acute PTE from DVT after playing tennis. A detailed history revealed that he had hit his popliteal vein with each swing of his tennis racket and the site of the trauma, at popliteal fossa, was exactly the same as the site of the DVT formation. Therefore, the cause of DVT was suspected to be the repeated trauma to the popliteal vein. The repeated external trauma to the popliteal vein may have caused vascular endothelial damage, leading to DVT.
(キーワード): Acute pulmonary thromboembolism / Deep vein thrombosis / Trauma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.01.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84897413698

(DOI: 10.1016/j.jccase.2014.01.001, Elsevier: Scopus) Kazumi Takaishi, Shinji Kawahito, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata and Hiroshi Kitahata :
Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation.,
Anaesthesia, Vol.69, No.2, 170-175, 2014.

(要約): J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in J waves and profound hypotension following a single intravenous dose of propofol in an 84-year-old woman with early repolarisation in the inferior ventricular wall. When early repolarisation (as shown by electrocardiographic J waves) is observed in the inferior ventricular wall pre-operatively, patients should be carefully monitored. Myocardial ischaemia and the use of drugs that might worsen J waves should be avoided.
(キーワード): Aged, 80 and over / Anesthetics, Intravenous / Electrocardiography / Female / Humans / Hypotension / Intraoperative Complications / Monitoring, Intraoperative / Propofol / Ventricular Fibrillation
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/anae.12448
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24116860; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892799834

(DOI: 10.1111/anae.12448, PubMed: 24116860, Elsevier: Scopus) Sachiko Matsumoto, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, K Yamakawa, H Masuzaki and Masataka Sata :
Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice.,
Cardiovascular Diabetology, Vol.13, No.1, 30, 2014.

(要約): BACKGROUND: Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benefits of azilsartan in diabetic vascular dysfunction have not been established.METHODS: We measured vascular reactivity of aortic rings in male KKAy diabetic mice treated with vehicle, 0.005% azilsartan, or 0.005% candesartan cilexetil for 3 weeks. Expression of markers of inflammation and oxidative stress was measured using semiquantitative RT-PCR in the vascular wall, perivascular fat, and skeletal muscle. Phosphorylation of eNOS at Ser1177 and Thr495 was measured using Western blotting, and the ratio of phosphorylation at Ser1177 to phosphorylation at Thr495 was used as a putative indicator of vascular eNOS activity.RESULTS: (1) Vascular endothelium-dependent relaxation with acetylcholine in KKAy mice was improved by azilsartan treatment compared to candesartan cilexetil; (2) the ratio of Ser1177/Thr495 phosphorylation of eNOS was impaired in KKAy and was effectively restored by azilsartan; (3) anomalies in the expression levels of MCP1, F4/80, Nox2, and Nox4 of the aortic wall and in the expression of TNFalpha in the perivascular fat were strongly attenuated by azilsartan compared to candesartan cilexetil.CONCLUSIONS: These results provide evidence that azilsartan prevents endothelial dysfunction in diabetic mice, more potently than does candesartan cilexetil. Azilsartan's higher affinity for and slower dissociation from AT1 receptors may underlie its efficacy in diabetic vascular dysfunction via a dual effect on uncoupled eNOS and on Nox.
(キーワード): Angiotensin II Type 1 Receptor Blockers / Animals / Benzimidazoles / Diabetes Mellitus, Experimental / Endothelium, Vascular / Male / Mice / Mice, Inbred C57BL / Nitric Oxide Synthase Type III / Organ Culture Techniques / Oxadiazoles / Phosphorylation / Serine / Threonine / Vasculitis / Vasodilation
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2840-13-30
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24485356; ● Summary page in Scopus @ Elsevier: 2-s2.0-84893161576

(DOI: 10.1186/1475-2840-13-30, PubMed: 24485356, Elsevier: Scopus) Takeshi Soeki, Toshiyuki Niki, E. Uematsu, S. Bando, T. Matsuura, Kenya Kusunose, Takayuki Ise, Yuka Ueda, N. Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Michio Shimabukuro, I. Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.,
Heart and Vessels, Vol.28, No.6, 795-801, 2013.

(要約): Vagal nerve stimulation has been postulated to confer an antifibrillatory effect. We studied whether ghrelin administration would exert an antiarrhythmic effect via modulation of autonomic nerve activity in rats after acute myocardial ischemia (MI). Male Sprague-Dawley rats were exposed to 30 min of ischemia following ligation of the left coronary artery. Animals were then randomized to receive either ghrelin (n = 26) or saline (n = 26) during the period of coronary ligation. Power spectral analysis of heart-rate variability revealed that the administration of ghrelin increased the high-frequency (HF) power and decreased the low-frequency (LF)/HF ratio. Ventricular tachyarrhythmias were less frequent in rats after MI who received ghrelin in comparison with rats that received saline. Immunoblotting and immunohistochemistry revealed that rats given saline alone during MI exhibited a marked reduction in phosphorylated connexin-43 within the left ventricle, whereas those that received ghrelin displayed only minor reductions in comparison with sham-operated rats. These effects of ghrelin were diminished by the coadministration of atropine or the blockade of vagal afferents. These data demonstrate that the beneficial effect of ghrelin might be mediated by modulation of cardiac autonomic nerve activity.
(キーワード): Animals / Anti-Arrhythmia Agents / Atropine / Connexin 43 / Disease Models, Animal / Ghrelin / Heart Rate / Heart Ventricles / Male / Muscarinic Antagonists / Myocardial Ischemia / Phosphorylation / Rats / Rats, Sprague-Dawley / Tachycardia, Ventricular / Time Factors / Vagotomy / Vagus Nerve
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0333-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23494606; ● Search Scopus @ Elsevier (PMID): 23494606; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-013-0333-2

(DOI: 10.1007/s00380-013-0333-2, PubMed: 23494606) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Daiju Fukuda, Masayoshi Ishida, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pharmacology of Aldosterone and the Effects of Mineralocorticoid Receptor Blockade on Cardiovascular Systems.,
Acta Cardiologica Sinica, Vol.29, No.3, 201-207, 2013.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84878307366

(Elsevier: Scopus) Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure.,
JACC. Cardiovascular Imaging, Vol.6, No.4, 528-530, 2013.

(キーワード): Angina, Stable / Atrial Function, Left / Atrial Pressure / Cardiac Catheterization / Case-Control Studies / Echocardiography, Doppler, Color / Humans / Mitral Valve / Multivariate Analysis / Predictive Value of Tests / Prospective Studies / Time Factors / Ventricular Function, Left / Ventricular Pressure
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2012.10.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23579016; ● Search Scopus @ Elsevier (PMID): 23579016; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2012.10.025

(DOI: 10.1016/j.jcmg.2012.10.025, PubMed: 23579016) Michio Shimabukuro, Y. Hirata, M. Tabata, M. Dagvasumberel, H. Sato, Hirotsugu Kurobe, Daiju Fukuda, Takeshi Soeki, Tetsuya Kitagawa, S. Takanashi and Masataka Sata :
Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.,
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.33, No.5, 1077-1084, 2013.

(要約): The impact of epicardial adipose tissue (EAT) over abdominal or overall adiposity on coronary artery disease (CAD) is currently unknown. We compared the association among EAT volume (EATV), cytokine/adipocytokine profiles in EAT and subcutaneous fat, and atherogenic CAD. APPROACH AND RESULTS: Paired samples were obtained from EAT and subcutaneous adipose tissue during elective cardiac surgery for CAD (n=50) or non-CAD (n=50). EATV was the sum of cross-sectional EAT areas, and visceral and subcutaneous fat areas were determined at the umbilicus level on computed tomography scans. CD68(+), CD11c(+), and CD206(+) cells were counted using immunohistochemical staining. Cytokine/adipocytokine expression was evaluated using quantitative real-time polymerase chain reaction. Multivariate analysis indicated that male sex, age, diabetes mellitus, high triglycerides, and low high-density lipoprotein cholesterol, and EATV index (EATV/body surface area, cm(3)/m(2)) were significant CAD predictors (corrected R(2)=0.401; P<0.001); visceral fat area, hypertension, smoking, low-density lipoprotein cholesterol (140 mg/dL [3.63 mmol/L]) or statin use were not predictors. The EATV index positively correlated with the CD68(+) and CD11c(+) cell numbers and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3), interleukin-1β, and interleukin-1R expression; and negatively correlated with adiponectin expression in EAT. A multivariate analysis model, including CD68(+) cells and interleukin-1β, and adiponectin expression in EAT strongly predicted CAD (corrected R(2)=0.756; P<0.001). EATV and macrophage and cytokine/adipocytokine signals in EAT strongly correlated with CAD. Our findings suggest that EATV and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.
(キーワード): Adipokines / Adipose Tissue / Aged / Antigens, CD / Antigens, CD11c / Antigens, Differentiation, Myelomonocytic / Cholesterol, HDL / Coronary Artery Disease / Female / Humans / Logistic Models / Male / Middle Aged / Pericardium
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/ATVBAHA.112.300829
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23471228; ● Search Scopus @ Elsevier (PMID): 23471228; ● Search Scopus @ Elsevier (DOI): 10.1161/ATVBAHA.112.300829

(DOI: 10.1161/ATVBAHA.112.300829, PubMed: 23471228) Tomoya Hara, Hirotsugu Yamada, Akira Takashima, Hiromu Yamasaki, Kozue Ogasawara, Sachiko Bando, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, Noriko Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Hidehisa Horiguchi, Naomi Sakashita and Masataka Sata :
Constrictive pericarditis with intrapericardial abscess.,
Circulation Journal, Vol.77, No.3, 786-788, 2013.

(キーワード): Abscess / Aged / Autopsy / Fatal Outcome / Heart Diseases / Humans / Male / Methicillin-Resistant Staphylococcus aureus / Pericarditis, Constrictive / Pericardium / Staphylococcal Infections
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-12-1098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23207988; ● Summary page in Scopus @ Elsevier: 2-s2.0-84874412877

(DOI: 10.1253/circj.CJ-12-1098, PubMed: 23207988, Elsevier: Scopus) N. Kawano, Koji Yamaguchi, Toshiyuki Niki, Yamamoto Takashi, Takashi Iwase, Yoshio Taketani, Takayuki Ise, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, K Kawano, A. Kakutani and Masataka Sata :
Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.,
Journal of Cardiology Cases, Vol.7, No.6, e176-e180, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2013.02.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84877831795

(DOI: 10.1016/j.jccase.2013.02.009, Elsevier: Scopus) Michio Shimabukuro, Chisayo Kozuka, Shin-ichiro Taira, Kouichi Yabiku, Munkhbaatar Dagvasumberel, Masayoshi Ishida, Sachiko Matsumoto, Shusuke Yagi, Daiju Fukuda, Ken Yamakawa, Moritake Higa, Takeshi Soeki, Hisashi Yoshida, Hiroaki Masuzaki and Masataka Sata :
Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine.,
The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 1-14, 2013.

(要約): The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity. J. Med. Invest. 60: 1-14, February, 2013.
(キーワード): 肥満症 (obesity) / インスリン抵抗性 (insulin resistance) / cardiovascular disease / 糖尿病 (diabetes mellitus)
(徳島大学機関リポジトリ): ● Metadata: 106036
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.60.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614905; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876035311

(徳島大学機関リポジトリ: 106036, DOI: 10.2152/jmi.60.1, PubMed: 23614905, Elsevier: Scopus) 高島啓, 伊勢孝之, 上田由佳, 岩瀬俊, 八木秀介, 前田香代子, 西川幸治, 小笠原梢, 坂東美佳, 坂東左知子, 冨田紀子, 仁木敏之, 發知淳子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
心臓リハビリテーション, Vol.18, No.1, 130-133, 2013年.

(キーワード): 酸化LDL / 心臓リハビリテーション / 心肺運動負荷試験
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381154583040

(CiNii: 1520010381154583040) T Hara, Koji Yamaguchi, Takashi Iwase, M Kadota, Mika Bando, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, N Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein.,
International Heart Journal, Vol.54, No.1, 51-53, 2013.

(要約): A 67-year-old woman with asthma visited our hospital with increasing dyspnea and new-onset paresthesia and purpura in her legs. Physical examination showed a wheeze, pretibial edema, and surrounding purpura. Chest X-rays showed cardiac decompensation and an electrocardiogram revealed a new ST-T change. Laboratory data showed leukocytosis, hypereosinophilia (10,450/μL), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> 150 ng/mL). Echocardiography revealed diffuse left ventricular hypokinesis (ejection fraction 30%) with increased wall thickness. Coronary angiography was normal. Cardiac magnetic resonance imaging implied diffuse myocardial edema and subendocardial late gadolinium enhancement. Skin biopsy of purpura showed superfi cial perivascular dermatitis with remarkable eosinophilic infiltrations. No evidence of drug allergies, parasitic infection, or myeloproliferative disorder was detected. Based on these findings, a diagnosis of eosinophilic myocarditis due to Churg-Strauss syndrome was considered. She was administered prednisolone at a dose of 1 mg/kg, cyclophosphamide, and diuretics. Several markers of eosinophilic myocarditis and heart failure gradually improved, including ECP. She was discharged 30 days later with no cardiac event. Eosinophilic myocarditis is characterized by predominantly eosinophilic infi ltration. Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. We experienced a rare case of eosinophilic myocarditis due to Churg-Strauss syndrome. Markedly elevated ECP played an important role in the early diagnosis and subsequent reduction in ECP served as a marker of monitoring. In an asthmatic patient with dyspnea, hypereosinophilia, and vasculitis, Churg-Strauss syndrome with eosinophilic myocarditis should be considered.
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.54.51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23428926; ● Search Scopus @ Elsevier (PMID): 23428926; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.54.51

(DOI: 10.1536/ihj.54.51, PubMed: 23428926) Hirata Yoichiro, Hirotsugu Kurobe, Nishio Chika, Tanaka Kimie, Daiju Fukuda, Uematsu Etsuko, Nishimoto Sachiko, Takeshi Soeki, Nagakatsu Harada, Hiroshi Sakaue, Tetsuya Kitagawa, Michio Shimabukuro, Yutaka Nakaya and Masataka Sata :
Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury.,
European Journal of Pharmacology, Vol.699, No.1-3, 106-111, 2013.

(要約): Exendin-4 is a glucagon-like peptide-1 receptor agonist that has been used as a drug for treatment of type 2 diabetes. To investigate the effect of exendin-4 on the cardiovascular system, we investigated the impact of exendin-4 on neointimal hyperplasia of the femoral artery after vascular injury. We performed wire-mediated endovascular injury in C57BL/6 mice, followed by administration of exendin-4 24 nmol/kg/day via infusion pump. Four weeks after the injury, exendin-4 treatment significantly attenuated neointimal hyperplasia of the injured artery, although it did not affect glucose metabolism and lipid profile in wild-type mice. Immunofluorescence study revealed abundant expression of GLP-1 receptor on α-smooth muscle actin-positive cells in the injured vessel. Cell proliferation assay using rat aortic smooth muscle cells showed that exendin-4 reduced PDGF-BB induced smooth muscle cell proliferation through the cAMP/PKA pathway. Exendin-4 also inhibited TNFα production by peritoneal macrophages in response to inflammatory stimulus. Our findings indicate that a GLP-1 receptor agonist attenuated neointimal formation after vascular injury. GLP-1 receptor agonists or drugs that raise endogenous GLP-1 level might be effective in the treatment of vascular diseases.
(キーワード): Exendin-4 / GLP-1 / endovascular injury / neointimal hyperplasia / diabetes mellitus
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2012.11.057
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23220706; ● Search Scopus @ Elsevier (PMID): 23220706; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2012.11.057

(DOI: 10.1016/j.ejphar.2012.11.057, PubMed: 23220706) Y. Fukuda, Takeshi Soeki and Masataka Sata :
A novel doppler echocardiographic index integrating left and right ventricular function is superior to conventional indices for predicting adverse outcome of acute myocardial infarction.,
The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 97-105, 2013.

(要約): The ratio of peak diastolic early velocity (E) of left ventricular (LV) inflow to peak diastolic longitudinal velocity (e') of the mitral annulus (E/e') is thought to reflect LV filling pressure, and tricuspid annulus velocity at systole (s'-T) is thought to reflect right ventricular function. However, it has not been reported on significance of the combined use of E/e' and (s'-T) to predict outcome of acute myocardial infarction (AMI). Over 21 months, beginning in January 2007, we enrolled 65 AMI patients who were measured hemodynamic and echocardiographic parameters by Swan-Ganz (SG) catheterization just after reperfusion therapy and echocardiography immediately after reperfusion therapy. Cardiac index (CI) and pulmonary capillary wedge pressure (PCWP) via SG catheter were measured, and routine echocardiographic indices, including E, e', E/e', and (s'-T) were determined. In addition, we defined the functional integrated bi-myocardial tissue Doppler (FIT) index as (s'-T)÷E/e'. The relationships between CI, PCWP, and echocardiographic indices were investigated, including FIT index. Moreover, we investigated whether FIT index could predict adverse cardiac events. FIT index was significantly associated with not only CI but also PCWP. In the Cox proportional hazards model, FIT index<1.0 was a significant predictor for adverse outcome of AMI after adjustment for age, Killip class, history of previous coronary revascularization, location of culprit lesion, and LV ejection fraction. The novel index defined as (s'-T)÷E/e' could be quite useful predictor of prognosis in AMI.
(キーワード): 経食道心エコー (transesophageal echocardiography) / tissue Doppler imaging / acute myocardial infarction / left ventricular filling pressure / right ventricular function
(徳島大学機関リポジトリ): ● Metadata: 111304
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.60.97
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614917; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876044555

(徳島大学機関リポジトリ: 111304, DOI: 10.2152/jmi.60.97, PubMed: 23614917, Elsevier: Scopus) Hirata Yoichiro, Hirotsugu Kurobe, Uematsu Etsuko, Shusuke Yagi, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, Michio Shimabukuro, Nakayama Mizuho, Matsumoto Kunio, Sakai Yoshiki, Tetsuya Kitagawa and Masataka Sata :
Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.,
European Journal of Pharmacology, Vol.699, No.1-3, 81-87, 2013.

(要約): Injury to the heart can result in cardiomyocyte hypertrophy, fibrosis, and cell death. Myocarditis sometimes progresses to dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig. Here, we investigated the therapeutic efficacy of ONO-1301 in a rat model of myosin-induced experimental autoimmune myocarditis, in which the heart transits from an acute inflammatory phase to a chronic dilated cardiomyopathy phase. Four weeks after myosin injection to Lewis rats, ONO-1301 (6 mg/kg/day) was orally administered for 4 weeks (ONO-1301 group). Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved by ONO-1301. Histological analysis revealed that capillary density in the myocardium was significantly increased by ONO-1301. ONO-1301 increased circulating endothelial progenitor cells (EPC) as determined by FACS analysis. These beneficial effects of ONO-1301 were partially abrogated by a neutralizing anti-HGF antibody (8 mg/kg/dose). These findings indicate beneficial effects of ONO-1301 in a rat experimental autoimmune myocarditis model.
(キーワード): 心不全 (heart failure) / HGF / dilated cardiomyopathy / experimental autoimmune myocarditis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2012.11.045
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23219794; ● Search Scopus @ Elsevier (PMID): 23219794; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2012.11.045

(DOI: 10.1016/j.ejphar.2012.11.045, PubMed: 23219794) Takeshi Soeki and Masataka Sata :
Role of epicardial adipose tissue in atrial fibrillation.,
Circulation Journal, Vol.76, No.12, 2738-2739, 2012.

(キーワード): Adipose Tissue / Atrial Fibrillation / Coronary Artery Disease / Female / Humans / Male / Multidetector Computed Tomography / Pericardium
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-12-1283
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23095722; ● Search Scopus @ Elsevier (PMID): 23095722; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-12-1283

(DOI: 10.1253/circj.CJ-12-1283, PubMed: 23095722) Asuka Shiota, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Hiromi Sato, Etsuko Uematsu, Hirata Yoichiro, Hirotsugu Kurobe, Maeda Norikazu, Hiroshi Sakaue, Masuzaki Hiroaki, Shimomura Iichiro and Masataka Sata :
Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice.,
Cardiovascular Diabetology, Vol.11, No.1, 139, 2012.

(要約): Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a partial agonist of the peroxisome proliferator-activated receptor (PPAR) γ, which is also targeted by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase (SIRT1). Here, we investigated the pathways through which telmisartan acts on skeletal muscle, in vitro as well as in vivo. Nine-week-old male db/db mice were fed a 60% high-fat diet, with orally administrated either vehicle (carboxymethyl-cellulose, CMC), 5 mg/kg telmisartan, or 5 mg/kg telmisartan and 1 mg/kg GW9662, a selective irreversible antagonist of PPARγ, for 5 weeks. Effects of telmisartan on Sirt1 mRNA, AMPK phosphorylation, and NAD+/NADH ratio were determined in C2C12 cultured myocytes. Telmisartan treatment improved insulin sensitivity in obese db/db mice fed a high-fat diet and led to reduction in the size of hypertrophic pancreatic islets in these mice. Moreover, in vitro treatment with telmisartan led to increased expression of Sirt1 mRNA in C2C12 skeletal muscle cells; the increase in Sirt1 mRNA in telmisartan-treated C2C12 myoblasts occurred concomitantly with an increase in AMPK phosphorylation, an increase in NAD+/NADH ratio, and increases in the mRNA levels of PGC1α, FATP1, ACO, and GLUT4. Our results indicate that telmisartan acts through a PPARγ-independent pathway, but at least partially exerts its effects by acting directly on skeletal muscle AMPK/SIRT1 pathways.
(キーワード): AMP-Activated Protein Kinases / Adipocytes / Administration, Oral / Angiotensin II Type 1 Receptor Blockers / Anilides / Animals / Benzimidazoles / Benzoates / Cell Line / Diabetes Mellitus / Diet, High-Fat / Disease Models, Animal / Dose-Response Relationship, Drug / Enzyme Activation / Fatty Acid Transport Proteins / Glucose Transporter Type 4 / Hypertrophy / Insulin / Islets of Langerhans / Male / Mice / Muscle Fibers, Skeletal / Muscle, Skeletal / NAD / Obesity / PPAR gamma / Phosphorylation / RNA, Messenger / Signal Transduction / Sirtuin 1 / Time Factors / Trans-Activators
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2840-11-139
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23137106; ● Search Scopus @ Elsevier (PMID): 23137106; ● Search Scopus @ Elsevier (DOI): 10.1186/1475-2840-11-139

(DOI: 10.1186/1475-2840-11-139, PubMed: 23137106) Munkhbaatar Dagvasumberel, Michio Shimabukuro, Nishiuchi Takeshi, Junji Ueno, Shoichiro Takao, Daiju Fukuda, Hirata Yoichiro, Hirotsugu Kurobe, Takeshi Soeki, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Tomita Noriko, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masafumi Harada, Tetsuya Kitagawa and Masataka Sata :
Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects.,
Cardiovascular Diabetology, Vol.11, No.1, 106, 2012.

(要約): Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Increased EATV is strongly associated with coronary atherosclerosis in men.
(キーワード): Adipose Tissue / Age Factors / Aged / Asian Continental Ancestry Group / Body Surface Area / Chi-Square Distribution / Coronary Angiography / Coronary Artery Disease / Coronary Stenosis / Female / Health Status Disparities / Humans / Japan / Logistic Models / Male / Middle Aged / Multidetector Computed Tomography / Multivariate Analysis / Pericardium / Predictive Value of Tests / Risk Assessment / Risk Factors / Severity of Illness Index / Sex Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2840-11-106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22963346; ● Search Scopus @ Elsevier (PMID): 22963346; ● Search Scopus @ Elsevier (DOI): 10.1186/1475-2840-11-106

(DOI: 10.1186/1475-2840-11-106, PubMed: 22963346) Asuka Shiota, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Hiromi Sato, Etsuko Uematsu, Yoichiro Hirata, Hirotsugu Kurobe, Hiroshi Sakaue, Yutaka Nakaya, Hiroaki Masuzaki and Masataka Sata :
Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects.,
European Journal of Pharmacology, Vol.692, No.1-3, 84-90, 2012.

(要約): Telmisartan exerts anti-metabolic effects beyond its angiotensin receptor blockade activities, but the mechanisms have hitherto remained elusive. We sought to elucidate the peroxisome proliferator-activated receptor-γ (PPAR-γ)-dependent and PPAR-γ-independent mechanisms underlying the anti-metabolic effects of telmisartan in white adipose tissue. Nine-week-old male C57BL/6 mice were fed with a 60% high-fat diet for 6 weeks, with 1mg/kg telmisartan or vehicle administrated orally during the last 3 weeks. 3T3-L1 adipocytes were cultured with telmisartan either with 2-chloro-5-nitro-N-phenylbenzamide (GW9662), a selective irreversible antagonist of PPAR-γ, or compound C, an ATP-competitive inhibitor of AMPK. Western blotting and semiquantitative RT-PCR analysis were used to assess adiponectin, Sirt1, and AMPK levels. Lipid accumulation was assessed by Oil red O staining. The activation of transcription factor PPAR-γ2 was evaluated by using a luciferase reporter assay for mPPAR-γ2 expression plasmid vector. Treatment with telmisartan increased serum adiponectin levels in high-fat diet-fed mice concomitantly with an upregulation of adiponectin mRNA in visceral adipose tissue. In vitro telmisartan treatment dose-dependently increased adiponectin mRNA in 3T3-L1 cells; the increase was inhibited by compound C, but not by GW9662. Telmisartan increased expression of Sirt1 mRNA and Sirt1 protein as well as the phosphorylation of AMPK in 3T3-L1 cells. Telmisartan can increase adiponectin production in white adipose tissue partly via a PPAR-γ2-independent mechanism. Precise understanding of this molecular mechanism will require further investigation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2012.07.026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22819702; ● Search Scopus @ Elsevier (PMID): 22819702; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2012.07.026

(DOI: 10.1016/j.ejphar.2012.07.026, PubMed: 22819702) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Junko Hotchi, Mika Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
Journal of the American Society of Echocardiography, Vol.25, No.9, 953-959, 2012.

(要約): Accurate assessment of left ventricular (LV) function in patients with atrial fibrillation (AF) remains difficult, mainly because of the beat-to-beat variability of many echocardiographic parameters. The aim of this study was to assess the hypothesis that LV function can be estimated from an index-beat echocardiographic assessment in patients with AF using myocardial strain and strain rate. A prospective study was conducted to assess 25 patients with AF (mean age, 66 ± 10 years). Peak systolic longitudinal strain (LS) and peak diastolic longitudinal strain rate (dSR) were measured using two different methods: (1) mean LS and dSR, the averages of instantaneous LS and dSR over 10 sec, and (2) index-beat LS and dSR, calculated when the ratio of the preceding (RR1) to the pre-preceding (RR2) interval was 1 (range, 0.96-1.04). These variables were compared with simultaneously measured LV pressure parameters using Millar catheters. There was a positive linear relationship between mean LS and index-beat LS at RR1/RR2 = 1 (r = 0.94, P < .001) and a positive linear relationship between mean dSR and index-beat dSR (r = 0.69, P < .001). Index-beat LS was correlated with the maximal positive derivative of LV pressure (peak +dP/dt) (r = -0.73, P < .001). Index-beat dSR was correlated with the time constant of isovolumic LV pressure decay (τ) (r = -0.63, P < .001). To investigate the independent predictors of τ, a stepwise multilinear regression analysis showed that index-beat dSR was the best predictor of τ. Index-beat parameters accurately reflect the mean values of parameters in patients with AF. These noninvasively obtained index-beat parameters are useful to assess surrogate LV function even in patients with AF.
(キーワード): Aged / Atrial Fibrillation / Diastole / Echocardiography, Doppler / Female / Heart Rate / Hemodynamics / Humans / Male / Myocardial Contraction / Prospective Studies / Regression Analysis / Reproducibility of Results / Systole
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2012.06.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22763085; ● Search Scopus @ Elsevier (PMID): 22763085; ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2012.06.009

(DOI: 10.1016/j.echo.2012.06.009, PubMed: 22763085) T. Hara, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Tetsuzo Wakatsuki and Masataka Sata :
Bicuspid aortic valve endocarditis complicated by perivalvular abscess.,
The Journal of Medical Investigation : JMI, Vol.59, No.3,4, 261-265, 2012.

(要約): A 37-year-old man presenting with fever and chest pain was admitted to our hospital. Electrocardiogram showed sinus tachycardia and complete left bundle branch block. Transthoracic echocardiogram showed infective endocarditis in the bicuspid aortic valve, complicated by multiple hyperechoic vegetations and severe aortic regurgitation. Blood cultures were negative and intravenous empiric antibiotic therapy was begun. However, fever lasted for 7 days and follow-up echocardiography revealed a newly emerged perivalvular abscess. The patient eventually underwent an urgent aortic root replacement that confirmed the echocardiographic findings. Our case report emphasizes that all patients with suspected aortic valve endocarditis should undergo early and follow-up echocardiographic studies.
(キーワード): bicuspid aortic valve / infectious endocarditis / perivalvular abscess / echocardiography
(徳島大学機関リポジトリ): ● Metadata: 106030
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.59.261
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23037197; ● Search Scopus @ Elsevier (PMID): 23037197; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.261

(徳島大学機関リポジトリ: 106030, DOI: 10.2152/jmi.59.261, PubMed: 23037197) 坂東美佳, 山田博胤, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 中川摩耶, 林修司, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 兼松康久, 里見淳一郎, 永廣信治 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの開発と臨床応用症例報告 (第28回徳島医学会賞受賞論文),
四国医学雑誌, Vol.68, No.3-4, 147-152, 2012年.

(要約): Background : The carotid plaque vulnerability is related to myocardial and cerebral infarction.We intended to develop an imaging system which enables to visualize tissue characteristics in thecarotid plaques based on ultrasound integrated backscatter(IB). And to test its clinical efficacy,effect of the statin therapy on the plaques was evaluated with our software. Methods and Results :Carotid ultrasound examination was performed and ultrasonographic RAW data of the plaqueswere obtained from8patients undergoing carotid artery endarterectomy. Tissue characteristicsin the plaques of resected examples were compared with preoperative ultrasonic images and thetissue IB values corresponding to the specimens were determined for developing our imaging system.Using this system, Color-coded maps of plaques in the three patients were constructed beforeand after lipid lowing therapy. We could demonstrate that lipid fraction in each plaque decreasedand fibrous or calcification fraction increased in the follow-up study. Conclusions : Changes inhistology of carotid plaques by statin could visualized with our imaging system. This techniquemay become a useful tool for the management of atherosclerosis.
(キーワード): IBS (integrated backscatter) / carotid plaque / CEA (carotid endarterectomy)
(徳島大学機関リポジトリ): ● Metadata: 102836
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812711314944

(徳島大学機関リポジトリ: 102836, CiNii: 1050282812711314944) Takeshi Soeki, Mitsuhiro Kitani, Kenya Kusunose, Shusuke Yagi, Yoshio Taketani, Kunihiko Koshiba, Tetsuzo Wakatsuki, Shunsuke Orino, Kazuhiro Kawano and Masataka Sata :
Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.,
Hypertension Research, Vol.35, No.11, 1058-1062, 2012.

(要約): Cilnidipine, an L/N-type calcium channel blocker (CCB), has been reported to have more beneficial effects on proteinuria progression in hypertensive patients than amlodipine, an L-type CCB. The N-type calcium channel blockade that inhibits renal sympathetic nerve activity might reduce glomerular hypertension by facilitating vasodilation of the efferent arterioles. However, the precise mechanism of the renoprotective effect of cilnidipine remains unknown. Because cilnidipine exerted significantly higher antioxidant activity than amlodipine in cultured human mesangial cells, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing oxidative stress. A total of 35 hypertensive patients receiving a renin-angiotensin system inhibitor were randomly assigned to a cilnidipine (n=18; 10 mg per day cilnidipine titrated to 20 mg per day) or amlodipine (n=17; 5 mg per day amlodipine titrated to 10 mg per day) group; the target blood pressure (BP) was set at 130/85 mmHg. After 6 months of treatment, systolic and diastolic BPs were significantly reduced in both of the groups, without any significant difference between the groups. The urinary albumin, 8-hydroxy-2'-deoxyguanosine (OHdG) and liver-type fatty-acid-binding protein (L-FABP) to creatinine ratios significantly decreased in the cilnidipine group (P<0.05) compared with those in the amlodipine group. The reductions in urinary albumin, 8-OHdG and L-FABP were not correlated with the change in systolic BP. In conclusion, cilnidipine, but not amlodipine, ameliorated urinary albumin excretion and decreased urinary 8-OHdG and L-FABP in the hypertensive patients. Cilnidipine probably exerts a greater renoprotective effect through its antioxidative properties.Hypertension Research advance online publication, 5 July 2012; doi:10.1038/hr.2012.96.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2012.96
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22763473; ● Search Scopus @ Elsevier (PMID): 22763473; ● Search Scopus @ Elsevier (DOI): 10.1038/hr.2012.96

(DOI: 10.1038/hr.2012.96, PubMed: 22763473) 久岡白陽花, 上田由佳, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 髙田信二郎, 赤池雅史, 安井夏生, 佐田政隆 :
(若手優秀演題セッション)尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
心臓リハビリテーション, Vol.17, No.1, 159-161, 2012年. Yoichiro Hirata, Michio Shimabukuro, Etsuko Uematsu, Takeshi Soeki, Hirotsugu Yamada, Yoshiki Sakai, Mizuho Nakayama, Kunio Matsumoto, Takashi Igarashi and Masataka Sata :
A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.,
European Journal of Pharmacology, Vol.674, No.2-3, 352-358, 2012.

(要約): ONO-1301, a synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, promotes the production of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) by various cell types. Here, we evaluated the therapeutic efficacy of ONO-1301 in rats with ischemia/reperfusion injury. Ligation of the left anterior descending arteries was performed in 10-week-old Wistar rats, and released 30 min later. A slow-release form of ONO-1301 was administered subcutaneously at 3h and 3 weeks after reperfusion injury. Hemodynamic parameters were significantly improved in the ONO-1301 group. Histological analysis revealed that ONO-1301 suppressed ischemic and fibrotic changes in the myocardium (ischemic area, control group: 58.6 ± 8.7% vs. ONO-1301 group: 44.4 ± 5.8%, fibrotic area, 33.5 ± 5.9% vs. 22.3 ± 6.2%, P<0.05, respectively), and enhanced neovascularization in the border zone. HGF expression was up-regulated by ONO-1301. Double-immunostaining revealed that myofibroblasts in the border zone of ischemic myocardium mainly expressed HGF. Our findings suggest that ONO-1301 might have therapeutic potential in treating ischemic heart disease.
(キーワード): Animals / Delayed-Action Preparations / Enzyme Inhibitors / Epoprostenol / Fibrosis / Heart / Hepatocyte Growth Factor / Male / Myocardium / Neovascularization, Physiologic / Pyridines / Rats / Rats, Wistar / Reperfusion Injury / Thromboxane-A Synthase
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejphar.2011.10.038
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22094066; ● Search Scopus @ Elsevier (PMID): 22094066; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejphar.2011.10.038

(DOI: 10.1016/j.ejphar.2011.10.038, PubMed: 22094066) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.,
International Journal of Cardiology, Vol.153, No.3, 272-276, 2011.

(要約): Late stent thrombosis (LST) after sirolimus-eluting stent (SES) implantation has been demonstrated previously. Although incomplete neointimal coverage after SES implantation has been reported, local long-term hypercoagulability remains unknown. We evaluated the local persistent coagulative response in eighty-three consecutive patients with stable angina, treated with either SES (n=51) or BMS (n=32) implantation for isolated de novo left anterior descending (LAD) stenosis. We measured prothrombin fragment F1+2 (frF1+2) and D-dimer levels sampled in the coronary sinus (CS) and sinus of Valsalva (V). The transcardiac gradient (Δ) was defined as the CS level minus V level. The ΔfrF1 + 2 and ΔD-dimer were significantly greater in the SES group than in the BMS group (0.50 ± 0.35 vs -0.14 ± 0.15 nmol/l, p=0.009 and 0.24 ± 0.21 vs -0.05 ± 0.16 μg/ml, p=0.041, respectively). We selected the hypocoagulative [ΔfrF1 + 2<0.15 (mean value-SD) nmol/l, n=21] and hypercoagulative [ΔfrF1 + 2>0.85 (mean value+SD) nmol/l, n=14] groups out of the SES patients. Multivariate analysis was performed to identify independent predictors of local hypercoagulability. Total SES length was the only independent predictor of local hypercoagulability. There was a significant positive correlation between the ΔfrF1 + 2 and total stent length in the SES group (r=0.57, p<0.05). An increased local coagulative response was observed in the convalescent phase after SES implantation as compared to BMS. Careful long-term follow-up of patients after longer SES implantation is recommended in order to avoid LST.
(キーワード): Aged / Angina, Stable / Cohort Studies / Coronary Thrombosis / Drug-Eluting Stents / Female / Humans / Male / Middle Aged / Sirolimus / Thrombophilia / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20826025; ● Search Scopus @ Elsevier (PMID): 20826025; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2010.08.014

(DOI: 10.1016/j.ijcard.2010.08.014, PubMed: 20826025) Hiromu Yamazaki, Koji Yamaguchi, Takashi Iwase, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Fukunaga, Hideki Nakanishi, Haruhiko Maruyama, Hiroyuki Matsuoka and Masataka Sata :
A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite.,
Journal of Cardiology Cases, Vol.4, No.2, e106-e109, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.06.005
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.06.005

(DOI: 10.1016/j.jccase.2011.06.005) Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Sachiko Bando, Yoichiro Hirata, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability.,
Journal of Cardiology, Vol.58, No.2, 151-157, 2011.

(要約): Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r=-0.67, p<0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture.
(キーワード): Aged / Angina Pectoris / Angiotensin II Type 1 Receptor Blockers / Benzimidazoles / Benzoates / Biological Markers / C-Reactive Protein / Coronary Artery Disease / Coronary Sinus / Disease Progression / Drug Monitoring / Female / Humans / Inflammation Mediators / Male / Middle Aged / Plaque, Atherosclerotic / Serum Amyloid P-Component / Severity of Illness Index / Tomography, Spiral Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2011.04.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21676590; ● Search Scopus @ Elsevier (PMID): 21676590; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2011.04.005

(DOI: 10.1016/j.jjcc.2011.04.005, PubMed: 21676590) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient.,
International Journal of Cardiology, Vol.150, No.1, e25-e27, 2011.

(要約): A 73-year-old woman suffering from anterior thoracic pain on exertion presented to our hospital. We performed coronary angiography and noted three stenotic legions in each coronary artery. For each angiographic finding, we implanted a bare metal stent (BMS), sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) into the right coronary artery, left anterior descending and left circumflex coronary arteries, respectively. Nine months later, she died of lung disease, and we could compare the histopathological findings among the three coronary stents. In the drug-eluting stents, very thin intima, infiltration of inflammatory cells, and fibrin deposition were observed, while thick intima and no inflammatory findings were observed in the BMS. Fibrin deposition was more marked in the PES than in the SES. This report shows marked differences in the subsequent pathological course among three stents in the same patient.
(キーワード): Aged / Coronary Stenosis / Drug-Eluting Stents / Female / Humans / Paclitaxel / Sirolimus / Stents
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.08.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19735952; ● Search Scopus @ Elsevier (PMID): 19735952; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.08.032

(DOI: 10.1016/j.ijcard.2009.08.032, PubMed: 19735952) M Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, N Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation.,
Internal Medicine, Vol.50, No.11, 1201-1206, 2011.

(要約): We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.
(キーワード): Adrenergic beta-Antagonists / Aged / Catheter Ablation / Comorbidity / Defibrillators, Implantable / Female / Humans / Magnetic Resonance Imaging / Sarcoidosis / Tachycardia, Ventricular / Treatment Failure / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.50.4580
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21628935; ● Search Scopus @ Elsevier (PMID): 21628935; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.50.4580

(DOI: 10.2169/internalmedicine.50.4580, PubMed: 21628935) Kenya Kusunose, Hirotsugu Yamada, Noriko Tomita, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis.,
International Journal of Cardiology, Vol.148, No.3, 47-50, 2011.

(要約): Most cases of chronic stenosis or occlusive lesions of the pulmonary arteries are attributed to thromboembolism, and pulmonary arteritis is extremely rare as the primary cause of these entities. We report a case of pulmonary stenosis and occlusion caused by Takayasu arteritis. The patient was a 54-year-old woman who presented with dyspnea. Total occlusion of the left pulmonary artery and significant stenosis of the right pulmonary artery caused by Takayasu arteritis were confirmed by various imaging modalities including pulmonary angiography, (18)fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging and real-time three-dimensional transesophageal echocardiography. After 6 weeks of steroid therapy, follow-up imaging studies showed that the stenotic lesion had resolved.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.02.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19299026; ● Search Scopus @ Elsevier (PMID): 19299026; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.02.036

(DOI: 10.1016/j.ijcard.2009.02.036, PubMed: 19299026) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension.,
International Journal of Cardiology, Vol.148, No.1, 125-127, 2011.

(キーワード): Aged / Aged, 80 and over / Female / Hemodynamics / Humans / Hypertension, Pulmonary / Intermittent Positive-Pressure Ventilation / Male / Middle Aged / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2011.01.074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21334081; ● Search Scopus @ Elsevier (PMID): 21334081; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2011.01.074

(DOI: 10.1016/j.ijcard.2011.01.074, PubMed: 21334081) Yoichiro Hirata, Takeshi Soeki, Hirotsugu Yamada, Asuka Shiota, Michio Shimabukuro, Yoshiki Sakai, Mizuho Nakayama, Kunio Matsumoto, Takashi Igarashi and Masataka Sata :
A synthetic prostacycline agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via up-regulation of HGF in rat.,
Biomedicine & Aging Pathology, Vol.1, No.2, 90-96, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.biomag.2011.06.004
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.biomag.2011.06.004

(DOI: 10.1016/j.biomag.2011.06.004) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.,
The American Journal of Cardiology, Vol.107, No.11, 1644-1649, 2011.

(要約): The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 ± 31.4 to 98.2 ± 19.4 mg/dl, p <0.01), triglycerides (from 157.7 ± 57.2 to 140.5 ± 60.7 mg/dl, p <0.01), E/e' (from 10.8 ± 6.2 to 9.0 ± 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 ± 55.9 to 28.5 ± 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-1 (from 709 ± 242 to 550 ± 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 ± 4.1 to 5.0 ± 3.1 g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 ± 14.6 to 29.4 ± 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress.
(キーワード): Aged / Albuminuria / Case-Control Studies / Cholesterol, LDL / Diastole / Female / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hyperlipidemias / Male / Middle Aged / Quinolines / Treatment Outcome / Triglycerides / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2011.01.054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21458773; ● Search Scopus @ Elsevier (PMID): 21458773; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2011.01.054

(DOI: 10.1016/j.amjcard.2011.01.054, PubMed: 21458773) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient.,
Journal of Cardiology Cases, Vol.3, No.3, e111-e114, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2011.03.007
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jccase.2011.03.007

(DOI: 10.1016/j.jccase.2011.03.007) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy.,
Circulation Journal, Vol.75, No.1, 141-147, 2011.

(要約): Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Segmental LS was measured by AFI in 60 patients with MI (67 ± 11 years) and 58 controls (71 ± 9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of 11% < LS to identify hypokinetic segments. The overall accuracy of wall motion scoring by LS in the 2,006 segments was 96.8% (κ = 0.90) compared with visual assessment. The correlation coefficient between LS and WT was R² = 0.65 in the 340 segments. Assessment of LV regional asynergy by AFI showed good agreement with visual and SPECT assessments. AFI is clinically useful for quantitative assessment of LV regional wall motion abnormalities.
(キーワード): Aged / Aged, 80 and over / Algorithms / Case-Control Studies / Echocardiography, Doppler / Feasibility Studies / Humans / Image Interpretation, Computer-Assisted / 日本 (Japan) / Middle Aged / Myocardial Contraction / Myocardial Infarction / Myocardial Perfusion Imaging / Observer Variation / Predictive Value of Tests / Reproducibility of Results / Tomography, Emission-Computed, Single-Photon / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0551
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21099120; ● Search Scopus @ Elsevier (PMID): 21099120; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0551

(DOI: 10.1253/circj.CJ-10-0551, PubMed: 21099120) 門田宗之, 竹谷善雄, 若槻哲三, 山口浩司, 楠瀬賢也, 仁木敏之, 坂東左知子, 久岡白陽花, 上田由佳, 冨田紀子, 竹内秀和, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 長井幸二郎, 土井俊夫 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
四国医学雑誌, Vol.66, No.5, 6, 175-180, 2010年.

(徳島大学機関リポジトリ): ● Metadata: 110339

(徳島大学機関リポジトリ: 110339) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.,
Internal Medicine, Vol.49, No.21, 2309-2312, 2010.

(要約): Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.
(キーワード): Exercise / Exercise Test / Female / Humans / Hypertension, Pulmonary / Middle Aged / Scleroderma, Systemic / Sulfonamides
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3812
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21048365; ● CiNii @ 国立情報学研究所 (CRID): 1390282679847104768; ● Search Scopus @ Elsevier (PMID): 21048365; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3812

(DOI: 10.2169/internalmedicine.49.3812, PubMed: 21048365, CiNii: 1390282679847104768) Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shoichiro Takao, Masafumi Harada, Noriko Kagawa, Eiji Kudo and Masataka Sata :
Images in cardiovascular medicine. Cardiac magnetic resonance imaging and 2-dimensional speckle tracking echocardiography in secondary cardiac amyloidosis.,
Circulation Journal, Vol.74, No.7, 1494-1496, 2010.

(キーワード): Aged / Amyloidosis / Echocardiography / Heart Diseases / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Mitral Valve / Regional Blood Flow
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0141
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20501956; ● Search Scopus @ Elsevier (PMID): 20501956; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0141

(DOI: 10.1253/circj.CJ-10-0141, PubMed: 20501956) Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions.,
Internal Medicine, Vol.49, No.10, 907-912, 2010.

(要約): Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.
(キーワード): congenital ventricular aneurysm / congenital ventricular diverticulum / ventricular arrythmia
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20467175; ● CiNii @ 国立情報学研究所 (CRID): 1390001204871212928; ● Search Scopus @ Elsevier (PMID): 20467175; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3008

(DOI: 10.2169/internalmedicine.49.3008, PubMed: 20467175, CiNii: 1390001204871212928) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Kazue Ishikawa, Takashi Iwase, Yasumasa Ikeda, Takeshi Soeki, Sumiko Yoshida, Yuka Sumitomo-Ueda, Toshio Matsumoto and Masataka Sata :
Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.,
Hypertension, Vol.55, No.4, 918-923, 2010.

(要約): Activation of the renin-angiotensin system exacerbates atrial remodeling, leading to atrial fibrillation and thrombosis, especially in a condition with decreased NO bioavailability. Recently, it has been reported that statins reduce the incidence of atrial fibrillation through attenuation of atrial remodeling; however, the mechanisms have not been completely elucidated. Therefore, we aimed to clarify the beneficial effect of statin on atrial remodeling in condition with reduced NO bioavailability. Endothelial NO synthase(-/-) mice were sham operated or infused with angiotensin II (Ang II) via an osmotic minipump for 2 weeks, and Ang II-infused mice were divided into 3 treatment groups: pitavastatin, Tempol (a free radical scavenger), or vehicle. Echocardiography and electrocardiography showed that Ang II infusion caused left atrial enlargement and a high incidence of atrial fibrillation, whereas pitavastatin and Tempol prevented these abnormalities. In histological analysis, Ang II-induced atrial interstitial fibrosis, perivascular fibrosis, and cardiomyocyte hypertrophy were all attenuated by pitavastatin and Tempol. Immunohistochemical staining showed that Ang II downregulated thrombomodulin and tissue factor pathway inhibitor and upregulated tissue factor and plasminogen activator inhibitor 1 in the left atrium and that pitavastatin and Tempol corrected the thrombogenic condition. Moreover, pitavastatin and Tempol reduced Ang II-induced atrial superoxide production and atrial transforming growth factor-beta1 expression and Smad 2/3 phosphorylation. Atrial rac1-GTPase activity, known to activate NADPH oxidase, was attenuated by pitavastatin but not by Tempol. In conclusion, pitavastatin exerts endothelial NO synthase-independent protective actions against Ang II-induced atrial remodeling and atrial fibrillation with enhanced thrombogenicity through suppression of oxidant injury.
(キーワード): Analysis of Variance / Angiotensin II / Animals / Antioxidants / Atrial Fibrillation / Blood Pressure / Blotting, Western / Cardiomegaly / Cyclic N-Oxides / Echocardiography / Fibrosis / Heart Atria / Heart Rate / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Male / Mice / Mice, Knockout / Myocytes, Cardiac / Nitric Oxide Synthase Type III / Oxidative Stress / Quinolines / Renin-Angiotensin System / Reverse Transcriptase Polymerase Chain Reaction / Signal Transduction / Smad2 Protein / Smad3 Protein / Spin Labels / Transforming Growth Factor beta1
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.109.146076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20194307; ● Search Scopus @ Elsevier (PMID): 20194307; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.109.146076

(DOI: 10.1161/HYPERTENSIONAHA.109.146076, PubMed: 20194307) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.,
Journal of Atherosclerosis and Thrombosis, Vol.17, No.2, 173-180, 2010.

(要約): AIM: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. METHODS: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age- and sex-matched patients with hypercholesterolemia (n=38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. RESULTS: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. CONCLUSION: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.
(キーワード): Aged / Albuminuria / Anticholesteremic Agents / Azetidines / C-Reactive Protein / Case-Control Studies / Cholesterol, LDL / Deoxyguanosine / Female / Humans / Hypercholesterolemia / Male / Metabolic Diseases / Metabolic Syndrome X / Middle Aged / Nitrates / Nitrites / Oxidative Stress / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.2378
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20150722; ● Search Scopus @ Elsevier (PMID): 20150722; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.2378

(DOI: 10.5551/jat.2378, PubMed: 20150722) Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo-Ueda, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, KI Aihara, Masafumi Harada, H Nishitani and Masataka Sata :
Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.,
Heart Asia, Vol.2, 52-55, 2010.

(出版サイトへのリンク): ● Publication site (DOI): 10.1136/ha.2010.002006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27325943; ● Search Scopus @ Elsevier (PMID): 27325943; ● Search Scopus @ Elsevier (DOI): 10.1136/ha.2010.002006

(DOI: 10.1136/ha.2010.002006, PubMed: 27325943) Y Hirata, Takeshi Soeki, Masashi Akaike, Y Sakai, T Igarashi and Masataka Sata :
Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.,
Biomedicine & Pharmacotherapy, Vol.63, No.10, 781-786, 2009.

(要約): Impairment of cardiac function in cardiomyopathy has been postulated to be related to decreased blood flow and increased collagen synthesis. Administration of growth factors was reported to attenuate left ventricular (LV) remodeling and dysfunction in animal models of dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor and vascular endothelial growth factor from various cell types and ameliorate ischemia-induced LV dysfunction in mice and pigs. We evaluated therapeutic efficacy of ONO-1301 in the Syrian hamster (TO-2), a model of genetically determined dilated cardiomyopathy. Either vehicle or a slow releasing form of ONO-1301 (ONO-1301-PLGA, 10mg/kg/3 weeks) was administered subcutaneously every 3 weeks to TO-2 hamsters from 24 to 32 weeks of age (n=12 for each group). Age-matched F1B hamsters were used as a control. Plasma concentration of HGF was elevated in ONO-1301-PLGA group (p<0.05). Echocardiographic study demonstrated that LV fractional shortening was significantly improved in the ONO-1301-PLGA group (25+/-4%, p<0.01) compared with that in the vehicle group (19+/-2%). Cardiac fibrosis was significantly reduced by ONO-1301-PLGA (p<0.05) as determined by Azan-Mallory staining. Capillary density of left ventricle was markedly reduced in TO-2 hamsters. ONO-1301-PLGA significantly increased capillary density in TO-2 group (p<0.05). ONO-1301 improved LV dysfunction and reduced cardiac fibrosis in the hamster model of dilated cardiomyopathy. ONO-1301 might hold a therapeutic potential in the treatment of dilated cardiomyopathy.
(キーワード): Animals / Cardiomyopathy, Dilated / Cricetinae / Delayed-Action Preparations / Disease Models, Animal / Drug Carriers / Enzyme Inhibitors / Fibrosis / Lactic Acid / Male / Myocardium / Polyglycolic Acid / Pyridines / Thromboxane-A Synthase / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.biopha.2009.09.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19906506; ● Search Scopus @ Elsevier (PMID): 19906506; ● Search Scopus @ Elsevier (DOI): 10.1016/j.biopha.2009.09.003

(DOI: 10.1016/j.biopha.2009.09.003, PubMed: 19906506) Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, K Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Y Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Utility of Single Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation with Preserved Systolic Function.,
JACC. Cardiovascular Imaging, Vol.2, No.10, 1147-1156, 2009.

(要約): We evaluated the usefulness of the ratio of the early diastolic transmitral flow velocity (E) to the mitral annular velocity (e') calculated from simultaneously recorded E and e' in atrial fibrillation (AF). The ratio of the E to the e' (E/e') has been reported as a useful index even in AF patients. However, E and e' were measured during different beats in the previous studies. Fifty-six AF patients with preserved systolic function (mean age 66 +/- 11 years) underwent routine echocardiographic study. The E/e' was calculated from the E and e' simultaneously recorded by the dual Doppler echocardiography. A single-beat E/e' was calculated from simultaneously recorded E and e' when the preceding RR interval/pre-preceding RR interval = 1. Brain natriuretic peptide (BNP) levels were also examined. Twenty-one patients underwent simultaneous pulmonary artery catheterization. The single-beat lateral E/e' correlated with pulmonary capillary wedge pressure (PCWP) (r = 0.74, p < 0.001). The single-beat lateral E/e' of >or=11 could predict elevated PCWP (>or=15 mm Hg) with a sensitivity of 90% and a specificity of 90%. The single-beat lateral E/e' also correlated well with the log BNP concentration. The single-beat lateral E/e' of >or=9.2 predicted a plasma BNP level of >or=200 pg/ml with 88% sensitivity and 84% specificity. The single-beat lateral E/e' correlated with plasma BNP level and PCWP in AF patients with preserved systolic function. In addition, the single-beat lateral E/e' (>or=11) was a good predictor of elevated PCWP (>or=15 mm Hg). Dual Doppler echocardiography offers an advantage of providing the single-beat lateral E/e' correctly even in AF patients, for the evaluation of left ventricular diastolic function.
(キーワード): Adult / Aged / Aged, 80 and over / Atrial Fibrillation / Biological Markers / Catheterization, Swan-Ganz / Coronary Circulation / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Heart Rate / Humans / Linear Models / Male / Middle Aged / Mitral Valve / Natriuretic Peptide, Brain / Predictive Value of Tests / Pulmonary Wedge Pressure / Sensitivity and Specificity / Systole / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2009.05.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19833302; ● Search Scopus @ Elsevier (PMID): 19833302; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2009.05.013

(DOI: 10.1016/j.jcmg.2009.05.013, PubMed: 19833302) Y Ono, Yutaka Nakaya, S Bando, Takeshi Soeki, Susumu Ito and Masataka Sata :
Telmisartan Decreases Plasma Levels of Asymmetrical Dimethyl-L-Arginine and Improves Lipid and Glucose Metabolism and Vascular Function,
International Heart Journal, Vol.50, No.1, 73-83, 2009.

(要約): Telmisartan is an angiotensin II receptor blocker (ARB) and also an activator of peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigated whether telmisartan improves vascular endothelial function in patients with essential hypertension with the production of endothelial nitric oxide synthase (eNOS) through PPAR-gamma.Telmisartan was administered to 15 patients with essential hypertension. To assess vascular function, asymmetric dimethylarginine (ADMA), an eNOS inhibitor synthesized by endothelial cells, and the pulse-wave velocity (PWV) were measured. The serum levels of lipid, glucose, and glycohemoglobin (HbA1c) were also evaluated before and after treatment. Telmisartan therapy significantly decreased the blood pressure and total- and LDL-cholesterol levels. HbA1c was also significantly improved but not in fasting plasma glucose. The serum levels of ADMA were significantly decreased (0.48 +/- 0.08 to 0.42 +/- 0.05 nmol/mL; P = 0.01). PWV values were significantly decreased by telmisartan from 1,822.5 +/- 352.3 to 1,661.5 +/- 299.8 cm/second (P = 0.04*). Telmisartan decreased PWV presumably via the activation of PPAR-gamma, suggesting that this agent improves vascular endothelial function via its pleiotropic effects, a mechanism that is different from its hypotensive effects.
(キーワード): Administration, Oral / Aged / Angiotensin II Type 1 Receptor Blockers / Arginine / Benzimidazoles / Benzoates / Blood Glucose / Blood Pressure / Cholesterol, LDL / Dose-Response Relationship, Drug / Endothelium, Vascular / Female / Humans / Hypertension / Male / Nitric Oxide Synthase Type III / PPAR gamma / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.50.73
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19246848; ● Search Scopus @ Elsevier (PMID): 19246848; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.50.73

(DOI: 10.1536/ihj.50.73, PubMed: 19246848) Kenya Kusunose, Hirotsugu Yamada, Takashi Todoroki, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Tetsuya Kitagawa and Masataka Sata :
Platypnea-orthodeoxia syndrome associated with patent foramen ovale and aortic ectasia.,
Echocardiography, Vol.26, No.1, 114-117, 2008.

(要約): A 59-year-old man was admitted for dyspnea on exertion and edema. The patient did not have any pulmonary diseases that could cause dyspnea. Transesophageal echocardiography on the tilting bed with contrast infusion revealed a right-to-left shunt through the patent foramen ovale. Therefore, he was diagosed as platypnea-orthodeoxia syndrome due to the patent foramen ovale. Surgical closure was done and all of his symptoms had improved.
(キーワード): Aortic Diseases / Dyspnea / 経食道心エコー (transesophageal echocardiography) / Edema, Cardiac / Foramen Ovale, Patent / Humans / Male / Middle Aged / 症候群 (syndrome) / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1540-8175.2008.00780.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19017323; ● Search Scopus @ Elsevier (PMID): 19017323; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1540-8175.2008.00780.x

(DOI: 10.1111/j.1540-8175.2008.00780.x, PubMed: 19017323) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki and Masashi Akaike :
A case of neurogenic myocardial stunning presenting transient left ventricular mid-portion ballooning simulating atypical takotsubo cardiomyopathy.,
Journal of Cardiology, Vol.52, No.1, 53-58, 2008.

(要約): A 57-year-old female patient, who was initially suspected to have subarachnoid hemorrhage, was admitted to our hospital. She experienced severe dyspnea and chest pain owing to pneumonia on the fourth admission day. Electrocardiography showed ST-segment elevation in leads V(2) through V(5), and echocardiography revealed hypokinetic left ventricular wall motion. No stenosis was found in the coronary arteries by urgent coronary angiography. However, left ventriculography revealed that the basal and apical areas were hyperkinetic and the mid portion was akinetic. After a month, left ventricular wall motion was improved and coronary artery spasm provocation tests were negative. Although the clinical course of this patient was similar to that of neurogenic myocardial stunning, the shape of her left ventricle was not typical.
(キーワード): Coronary Angiography / Diagnosis, Differential / Echocardiography / Electrocardiography / Female / Humans / Middle Aged / Myocardial Stunning / Takotsubo Cardiomyopathy / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2008.03.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18639778; ● Search Scopus @ Elsevier (PMID): 18639778; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2008.03.004

(DOI: 10.1016/j.jjcc.2008.03.004, PubMed: 18639778) 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
Therapeutic Research, Vol.27, No.2, 249-253, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-34249101008

(Elsevier: Scopus) 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 伊東進, 野村昌弘 :
心肥大を合併する本態性高血圧患者におけるアゼルニジピンによる抗動脈効果作用および心肥大抑制作用の検討,
Therapeutic Research, Vol.27, 115-120, 2006年.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-77954413525

(Elsevier: Scopus) T Tokudome, T Horio, I Kishimoto, Takeshi Soeki, K Mori, Y Kawano, M Khono, DL Garbers, K Nakao and K Kangawa :
Calcineurin-NFAT pathway-dependent cardiac remodeling in mice deficient for GC-A, a receptor for atrial and brain natriuretic peptides.,
Circulation, Vol.111, No.23, 3095-3104, 2005.

(要約): Although disruption of guanylyl cyclase (GC) A, a natriuretic peptide receptor, induces cardiac hypertrophy and fibrosis, the molecular mechanism underlying these effects are not well understood. In this study, we examined the role of calcineurin, a calcium-dependent phosphatase, in cardiac remodeling in GCA-knockout (GCA-KO) mice. At 14 weeks of age, calcineurin activity, nuclear translocation of nuclear factor of activated T cells c3 (NFATc3), and modulatory calcineurin-interacting protein 1 (MCIP1) gene expressions were increased in the hearts of GCA-KO mice compared with wild-type (WT) mice. Blockade of calcineurin activation by FK506 (6 mg/kg body weight administered subcutaneously once a day from 10 to 14 weeks of age) significantly decreased the heart-to-body weight ratio, cardiomyocyte size, and collagen volume fraction in GCA-KO mice, whereas FK506 did not affect these parameters in WT mice. Overexpression of atrial and brain natriuretic peptides, collagen, and fibronectin mRNAs in GCA-KO mice was also attenuated by FK506. Electrophoretic mobility shift assays demonstrated that GATA4 DNA-binding activity was increased in GCA-KO mice, and this increase was inhibited by calcineurin blockade. In neonatal cultured cardiac myocytes, inhibition of GCA by HS142-1 (100 microg/mL) increased basal and phenylephrine (10(-6) mol/L)-stimulated calcineurin activity, nuclear translocation of NFATc3, and MCIP1 mRNA expression. In contrast, activation of GCA by atrial natriuretic peptide (10(-6) mol/L) inhibited phenylephrine (10(-6) mol/L)-stimulated nuclear translocation of NFATc3. These results suggest that activation of cardiac GCA by locally secreted natriuretic peptides protects the heart from excessive cardiac remodeling by inhibiting the calcineurin-NFAT pathway.
(キーワード): Animals / Atrial Natriuretic Factor / Calcineurin / Cardiomegaly / Enzyme Activation / Fibrosis / Gene Expression Regulation / Guanylate Cyclase / Intracellular Signaling Peptides and Proteins / Mice / Mice, Knockout / Muscle Proteins / Myocardium / NFATC Transcription Factors / Natriuretic Peptide, Brain / RNA, Messenger / Receptors, Atrial Natriuretic Factor / Tacrolimus
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.104.510594
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15939815; ● Search Scopus @ Elsevier (PMID): 15939815; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCULATIONAHA.104.510594

(DOI: 10.1161/CIRCULATIONAHA.104.510594, PubMed: 15939815) Takeshi Soeki, I Kishimoto, H Okumura, T Tokudome, T Horio, K Mori and K Kangawa :
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction,
Journal of the American College of Cardiology, Vol.45, No.4, 608-616, 2005.

(要約): We assessed the hypothesis that in vivo administration of C-type natriuretic peptide (CNP) might attenuate cardiac remodeling after myocardial infarction (MI) through its antifibrotic and antihypertrophic action. Recently, we have shown that CNP has more potent antifibrotic and antihypertrophic effects than atrial natriuretic peptide (ANP) in cultured cardiac fibroblasts and cardiomyocytes. Experimental MI was induced by coronary ligation in male Sprague-Dawley rats; CNP at 0.1 mug/kg/min (n = 34) or vehicle (n = 35) was intravenously infused by osmotic mini-pump starting four days after MI. Sham-operated rats (n = 34) served as controls. After two weeks of infusion, the effects of CNP on cardiac remodeling were evaluated by echocardiograpic, hemodynamic, histopathologic, and gene analysis. C-type natriuretic peptide markedly attenuated the left ventricular (LV) enlargement caused by MI (LV end-diastolic dimension, sham: 6.7 +/- 0.1 mm; MI+vehicle; 8.3 +/- 0.1 mm; MI+CNP: 7.7 +/- 0.1 mm, p < 0.01) without affecting arterial pressure. Moreover, there was a substantial decrease in LV end-diastolic pressure, and increases in dP/dt(max), dP/dt(min), and cardiac output in CNP-treated MI rats compared with vehicle-treated MI rats. Importantly, CNP infusion markedly attenuated an increase in morphometrical collagen volume fraction in the noninfarct region (sham: 3.1 +/- 0.2%; MI+vehicle: 5.7 +/- 0.5%; MI+CNP: 3.9 +/- 0.3%, p < 0.01). In addition, CNP significantly reduced an increase in cross-sectional area of the cardiomyocytes. These effects of CNP were accompanied by suppression of MI-induced increases in collagen I, collagen III, ANP, and beta-myosin heavy chain messenger ribonucleic acid levels in the noninfarct region. These data suggest that CNP may be useful as a novel antiremodeling agent.
(キーワード): Animals / Cardiomegaly / Fibrosis / Male / Myocardial Infarction / Natriuretic Peptide, C-Type / Rats / Rats, Sprague-Dawley / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2004.10.067
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15708711; ● Search Scopus @ Elsevier (PMID): 15708711; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jacc.2004.10.067

(DOI: 10.1016/j.jacc.2004.10.067, PubMed: 15708711) T Tokudome, T Horio, Takeshi Soeki, K Mori, I Kishimoto, S Suga, F Yoshihara, Y Kawano, M Kohno and K Kangawa :
Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.,
Endocrinology, Vol.145, No.5, 2131-2140, 2004.

(要約): C-type natriuretic peptide (CNP) is known to play a role in the local regulation of vascular tone. We recently found that CNP is also produced by cardiac ventricular cells. However, its local effect on myocyte hypertrophy remains to be elucidated. The present study investigated the effects of CNP on cultured cardiac myocyte hypertrophy and the interaction between CNP and endothelin-1 (ET-1) signaling pathways. CNP attenuated basal and ET-1-augumented protein synthesis, atrial natriuretic peptide secretion, hypertrophy-related gene expression, GATA-4 and MEF-2 DNA binding activities, Ca(2+)/calmodulin-dependent kinase II activity, and ERK phosphorylation. CNP also inhibited ET-1-induced increase in intracellular Ca(2+) concentration. These effects of CNP were mimicked by a cGMP analog, 8-bromo cGMP. However, the inhibitory effects of CNP on the hypertrophic response of myocytes were significantly diminished at high concentrations of ET-1. Although CNP increased intracellular cGMP levels in myocytes, ET-1 suppressed CNP-induced cellular cGMP accumulation. A protein kinase C activator and Ca(2+) ionophore mimicked this suppressive effect of ET-1. We further examined the effect of CNP on the paracrine action of ET-1 secreted from cardiac nonmyocytes. CNP and 8-bromo cGMP significantly inhibited ET-1 secretion from nonmyocytes. Although nonmyocyte-conditioned medium increased the protein synthesis in myocytes through endogenous ET-1 action, this increase was significantly attenuated by pretreatment of nonmyocytes with CNP and 8-bromo cGMP. These findings demonstrate that CNP inhibits ET-1-induced cardiac myocyte hypertrophy via a cGMP-dependent mechanism, and conversely, ET-1 inhibits CNP signaling by a protein kinase C- and Ca(2+)-dependent mechanism, suggesting mutual interference between CNP and ET-1 signaling pathways.
(キーワード): Animals / Calcium / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Calcium-Calmodulin-Dependent Protein Kinases / Cardiomegaly / Cells, Cultured / Cyclic GMP / DNA / DNA-Binding Proteins / Drug Interactions / Endothelin-1 / GATA4 Transcription Factor / Mitogen-Activated Protein Kinases / Myocardium / Myogenic Regulatory Factors / Natriuretic Peptide, C-Type / Phosphorylation / Rats / Rats, Wistar / Signal Transduction / Transcription Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1210/en.2003-1260
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14749356; ● Search Scopus @ Elsevier (PMID): 14749356; ● Search Scopus @ Elsevier (DOI): 10.1210/en.2003-1260

(DOI: 10.1210/en.2003-1260, PubMed: 14749356) Takeshi Soeki, Y Tamura, H Shinohara, K Sakabe, Y Onose and N Fukuda :
Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis.,
Circulation Journal, Vol.68, No.1, 1-5, 2004.

(要約): Vascular endothelial (VE)-cadherin, a Ca(2+)-dependent cell adhesion molecule, is expressed in atherosclerotic lesions by endothelial cells and is associated with neovascularization, although the relationship between circulating VE-cadherin and coronary artery disease has not been studied. The plasma concentration of VE-cadherin was measured in peripheral blood (femoral artery) and the coronary sinus of 24 patients with acute myocardial infarction (AMI), 26 with stable angina pectoris (AP), 18 with old myocardial infarction (OMI), and 30 control subjects (Control) who had no coronary artery stenosis on angiography. For the patients with AMI, blood samples were obtained in the acute (day 1) and chronic (day 21) phases. The plasma concentration of VE-cadherin was measured by enzyme-linked immunosorbent assay. The correlation between the plasma VE-cadherin concentration and the Gensini score was also determined as an index of the severity of coronary atherosclerosis. The plasma concentrations of VE-cadherin (ng/ml) in both the peripheral and coronary sinus blood were higher in patients with AMI, AP, and OMI than in the control subjects, and were similar in the 3 groups with coronary artery disease (femoral artery: AMI 5.1+/-2.5, AP 4.7+/-2.4, OMI 4.5+/-3.3, Control 2.6+/-2.3; coronary sinus: AMI 5.6+/-2.6, AP 5.0+/-2.3, OMI 5.0+/-2.9, Control 2.4+/-2.1, respectively). Plasma VE-cadherin concentrations were higher in the coronary sinus than peripheral blood samples in patients with AMI (p<0.01), AP (p<0.01), and OMI (p<0.05). The plasma VE-cadherin concentration was the same in the acute and chronic phases in patients with AMI. In the 3 groups of patients with coronary disease, both the peripheral plasma VE-cadherin concentration and the coronary sinus concentration correlated with the Gensini score (r=0.32, p<0.01 and r=0.42, p<0.001, respectively). Multiple regression analysis revealed that the plasma VE-cadherin concentration predicted the Gensini score independently of sex, age, hypertension, diabetes mellitus, smoking, and the lipid profiles. Increased secretion of VE-cadherin from the epicardial arteries is associated with the degree of coronary atherosclerosis, indicating the presence of atherosclerosis rather than disease activity.
(キーワード): Aged / Angina Pectoris / Antigens, CD / Cadherins / Coronary Artery Disease / Endothelium, Vascular / Female / Humans / Male / Middle Aged / Myocardial Infarction / Reference Values / Regression Analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.68.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14695457; ● CiNii @ 国立情報学研究所 (CRID): 1390282680081347072; ● Search Scopus @ Elsevier (PMID): 14695457; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.68.1

(DOI: 10.1253/circj.68.1, PubMed: 14695457, CiNii: 1390282680081347072) Takeshi Soeki, Y Tamura, H Shinohara, K Sakabe, Y Onose and N Fukuda :
Increased soluble platelet/endothelial cell adhesion molecule-1 in the early stages of acute coronary syndromes.,
International Journal of Cardiology, Vol.90, No.2-3, 261-268, 2003.

(要約): Specific molecules including inflammatory cell adhesion molecules mediate attachment of blood leukocyte and platelets to the endothelium and mononuclear cell migration into the arterial intima. However, the clinical significance of soluble cell adhesion molecules very early in the course of acute coronary syndrome is not known. We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls. Blood samples were obtained on hospital admission and again 1 week after onset of AMI and unstable angina, and on admission in patients with stable angina and controls. Plasma PECAM-1 concentration (ng/ml) on admission was higher in patients with AMI (25.6+/-4.7) and unstable angina (24.7+/-4.4) than in stable angina (20.5+/-4.4) and control (18.8+/-3.8) groups. In both AMI and unstable angina, plasma PECAM-1 had decreased significantly by 1 week (AMI, 20.8+/-4.0; unstable angina, 21.0+/-4.1). Plasma ICAM-1 concentration (ng/ml) on admission was higher in patients with AMI (254+/-70), unstable angina (264+/-78), and stable angina (245+/-68) than in controls (201+/-56), but did not differ between the three coronary syndromes. Plasma P-selectin concentration did not differ between the four groups, including controls. Therefore, soluble PECAM-1 concentration may be a sensitive markers providing early diagnostic aid in acute coronary syndromes.
(キーワード): Aged / Analysis of Variance / Angina Pectoris / Angina, Unstable / Antigens, CD31 / Biological Markers / Case-Control Studies / Chi-Square Distribution / Female / Humans / Intercellular Adhesion Molecule-1 / Male / Middle Aged / Myocardial Infarction / P-Selectin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0167-5273(02)00564-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12957760; ● Search Scopus @ Elsevier (PMID): 12957760; ● Search Scopus @ Elsevier (DOI): 10.1016/S0167-5273(02)00564-8

(DOI: 10.1016/S0167-5273(02)00564-8, PubMed: 12957760) Koichi Sakabe, Nobuo Fukuda, Takeshi Soeki, H Shinohara, Y Tamura, Tetsuzo Wakatsuki, Akiyoshi Nishikado and Takashi Oki :
Relation of age and sex to atrial electrophysiological properties in patients with no history of atrial fibrillation.,
Pacing and Clinical Electrophysiology, Vol.26, No.5, 1238-1244, 2003.

(要約): Although atrial fibrillation is a common arrhythmia, especially in elderly men, little is known about age related changes in atrial electrophysiological properties or gender differences. The aim of this study was to analyze the effects of aging on vulnerability to atrial fibrillation and assessed gender differences in those age related changes. An electrophysiological study was performed on 73 patients with no history of atrial fibrillation, structural heart disease, or conditions with potential effects on cardiac hemodynamic or electrophysiological function, including 25 women (mean age 49 +/- 18 years; range 12-84 years). The following atrial excitability parameters were assessed: spontaneous or paced (A1) and extrastimulated (A2) atrial electrogram widths, percent maximum atrial fragmentation (A2/A1 x 100), effective refractory period, wavelength index (effective refractory period/A2), and inducibility of atrial fibrillation. There were no significant differences in percent maximum atrial fragmentation (143 +/- 28 vs 142 +/- 35%), effective refractory period (241 +/- 39 vs 238 +/- 50 ms), wavelength index (2.9 +/- 0.8 vs 3.1 +/- 0.9), induction of atrial fibrillation (10 [21%] vs 7 [28%]), or age (50 +/- 17 vs 49 +/- 20 years) between men and women. Age was not statistically different between those patients with and without induction of atrial fibrillation in men (48 +/- 14 vs 50 +/- 18 years) and women (48 +/- 18 vs 49 +/- 21 years). Percent maximum atrial fragmentation and effective refractory period were directly correlated with age in men (r = 0.35, P = 0.01; r = 0.46, P < 0.001, respectively) and women (r = 0.42, P = 0.04; r = 0.45, P = 0.02, respectively), though wavelength index did not correlate with age in men (r = -0.04) or women (r = -0.04) with no history of atrial fibrillation. Considering these findings, the authors conclude that the mechanism triggering atrial fibrillation may be different between older and younger patients with atrial fibrillation, because younger patients who have no marked substrate for atrial fibrillation may need many trigger beats to induce atrial fibrillation.
(キーワード): Adolescent / Adult / Age Factors / Aged / Aged, 80 and over / Aging / Atrial Fibrillation / Chi-Square Distribution / Child / Electrophysiologic Techniques, Cardiac / Female / Heart Atria / Humans / Linear Models / Male / Middle Aged / Sex Factors / Wolff-Parkinson-White Syndrome
(出版サイトへのリンク): ● Publication site (DOI): 10.1046/j.1460-9592.2003.t01-1-00174.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12765452; ● Search Scopus @ Elsevier (PMID): 12765452; ● Search Scopus @ Elsevier (DOI): 10.1046/j.1460-9592.2003.t01-1-00174.x

(DOI: 10.1046/j.1460-9592.2003.t01-1-00174.x, PubMed: 12765452) Takeshi Soeki, Y Tamura, H Shinohara, K Sakabe, Y Onose and N Fukuda :
Relation between circulating soluble Fas ligand and subsequent ventricular remodelling following myocardial infarction,
Heart, Vol.89, No.3, 339-441, 2003.

(キーワード): Fas Ligand Protein / Female / Humans / Male / Membrane Glycoproteins / Middle Aged / Myocardial Infarction / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/heart.89.3.339
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12591854; ● Search Scopus @ Elsevier (PMID): 12591854; ● Search Scopus @ Elsevier (DOI): 10.1136/heart.89.3.339

(DOI: 10.1136/heart.89.3.339, PubMed: 12591854) H Shinohara, N Fukuda, Takeshi Soeki, K Sakabe, Y Onose and Y Tamura :
Effects of angiotensin II receptor antagonists on [(123)I]metaiodobenzylguanidine myocardial imaging findings and neurohumoral factors in chronic heart failure,
Heart and Vessels, Vol.17, No.0, 47-52, 2002.

(要約): Previous studies have not investigated the ef-ficacy of angiotensin II (AII) receptor antagonists against cardiac sympathetic overactivity in patients with chronic heart failure (CHF) using [(123)I]metaiodobenzylguanidine (MIBG) myocardial imaging. We studied 34 CHF patients with fractional shortening of the left ventricular (LV) diameter <==25% or LV ejection fraction <==45% in echocardiograms. An AII receptor antagonist (losartan or candesartan) was administered. Before and 6 months after the administration, MIBG myocardial imaging and echocardiography were performed, and neurohumoral factors were investigated. MIBG imaging revealed that the antagonist did not significantly change the heart-to-mediastinum ratio. However, the washout rate fell significantly (from 32.6% +/- 7.6% to 28.2% +/- 7.5%; P < 0.001). No significant changes occurred in LV diameter, fractional shortening, or LV ejection fraction. Circulating atrial (ANP) and brain natriuretic peptides (BNP), and aldosterone fell significantly. Changes in the MIBG washout rate correlated positively with changes in BNP ( r = 0.35, P < 0.05). In 19 patients also being treated with angiotensin-converting enzyme (ACE) inhibitors, the MIBG washout rate also fell significantly with AII antagonists, as did BNP and aldosterone. The decreased MIBG washout and BNP in patients with CHF induced by the AII receptor antagonists suggests the efficacy of these agents in modifying cardiac sympathetic function and neurohumoral factors, even with ACE inhibition. Combination therapy with AII receptor antagonists and ACE inhibitors appears effective for CHF.
(キーワード): 3-Iodobenzylguanidine / Aged / Aged, 80 and over / Aldosterone / Angiotensin Receptor Antagonists / Angiotensin-Converting Enzyme Inhibitors / Antihypertensive Agents / Atrial Natriuretic Factor / Benzimidazoles / Biological Markers / Blood Pressure / Creatinine / Echocardiography / Female / Heart / Heart Failure / Humans / Losartan / Male / Middle Aged / Natriuretic Peptide, Brain / Neurotransmitter Agents / Norepinephrine / Potassium / Radiopharmaceuticals / Receptors, Angiotensin / Renin / Severity of Illness Index / Statistics as Topic / Stroke Volume / Tetrazoles / Time Factors / Treatment Outcome / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s003800200042
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12541093; ● CiNii @ 国立情報学研究所 (CRID): 1573387451537441920; ● Search Scopus @ Elsevier (PMID): 12541093; ● Search Scopus @ Elsevier (DOI): 10.1007/s003800200042

(DOI: 10.1007/s003800200042, PubMed: 12541093, CiNii: 1573387451537441920) Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Koichi Sakabe, Yukiko Onose and Nobuo Fukuda :
Serum hepatocyte growth factor predicts ventricular remodeling following myocardial infarction,
Circulation Journal, Vol.66, No.11, 1003-1007, 2002.

(要約): Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) stimulate endothelial cell proliferation and induce angiogenesis, but the timing and significance of their release in patients with acute myocardial infarction (AMI) are unknown in relation to future left ventricular remodeling. Venous blood samples were obtained at admission and up to 3 weeks later in 40 patients with AMI and in 40 age- and sex-matched control subjects. Blood samples were also taken from the coronary sinus (CS) in 20 patients on day 7 following AMI. Left ventricular end-diastolic volume in the subacute (1 week) and chronic (3 months) phases was assessed by left ventriculography to identify the remodeling group (n=15), which was defined as an increase in left ventricular end-diastolic volume index > or =5 ml/m(2) relative to the baseline value. Serum HGF and VEGF concentrations were higher in newly admitted patients with AMI than in the controls (HGF, 0.33 +/-0.09 vs 0.24+/-0.08 ng/ml, p<0.01; VEGF, 92.2+/-43.1 vs 67.2+/-29.8 pg/ml, p<0.01), peaking on day 7 (HGF, 0.41+/-0.12; VEGF, 161.7+/-76.9), and gradually decreasing between days 14 and 21. The HGF concentration in the CS did not differ from the concentration in the periphery, but the VEGF concentration was significantly more abundant in the CS than in the peripheral sample on day 7 (p<0.05). The serum HGF concentration on day 7 was higher in the remodeling group than in the nonremodeling group (0.47 +/-0.13 vs 0.36+/-0.09 ng/ml, p<0.01), but there was no difference between the groups on admission, day 14 and day 21. The serum VEGF concentration did not differ between the remodeling and nonremodeling groups at any time. Thus, the serum HGF concentration on day 7 after AMI is mostly from noncardiac sources and predicts left ventricular remodeling.
(キーワード): Aged / Coronary Circulation / Endothelial Growth Factors / Female / Hepatocyte Growth Factor / Humans / Intercellular Signaling Peptides and Proteins / Lymphokines / Male / Middle Aged / Myocardial Infarction / Predictive Value of Tests / Stroke Volume / Vascular Endothelial Growth Factor A / Vascular Endothelial Growth Factors / Ventricular Function, Left / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.66.1003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12419930; ● Search Scopus @ Elsevier (PMID): 12419930; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.66.1003

(DOI: 10.1253/circj.66.1003, PubMed: 12419930) Takeshi Soeki, Y Tamura, H Shinohara, K Sakabe, Y Onose and N Fukuda :
Plasma concentrations of fibrinolytic factors in the subacute phase of myocardial infarction predict recurrent myocardial infarction or sudden cardiac death,
International Journal of Cardiology, Vol.85, No.2-3, 277-283, 2002.

(要約): The prognostic value of plasma concentrations of tissue type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein has been reported in patients with coronary artery disease. However, the association between cardiac events and these factors during the acute and subacute phases of myocardial infarction (MI) is unknown. The purpose of this study was to determine whether elevated plasma concentrations of t-PA, PAI-1, and C-reactive protein in patients with MI are associated with future recurrent MI or sudden cardiac death. We studied 106 consecutive patients who survived a confirmed first MI between 1993 and 1998 in our hospital. The control group consisted of 50 patients who had no significant coronary artery stenosis. Blood samples were obtained at the time of admission for acute MI and on the 28th day after admission. Patients were followed for a mean of 50 months after these measurements. The primary end points were sudden cardiac death and fatal or nonfatal acute MI. Of the 92 patients who were available for follow-up, 10 had cardiac events. Both the plasma t-PA and PAI-1 concentrations were elevated on day 1 of acute MI compared to the control group and decreased by day 28, but remained higher than those in the controls. Plasma C-reactive protein concentration was also elevated on day 1 and decreased by day 28. Using a stepwise variable choice model of Cox proportional hazards analysis including these fibrinolytic factors and C-reactive protein, only the t-PA concentration in the subacute phase was a significant predictor of cardiac events (relative risk per S.D. 3.20, P<0.01). We further found that independent of other risk factors, an elevated t-PA concentration was predictive of cardiac events. This study reveals that a rise in endogenous t-PA concentration during the subacute phase of MI could predict recurrent MI or sudden cardiac death.
(キーワード): Aged / Biological Markers / C-Reactive Protein / Death, Sudden, Cardiac / Female / Fibrinolysis / Humans / Male / Middle Aged / Myocardial Infarction / Plasminogen Activator Inhibitor 1 / Prognosis / Proportional Hazards Models / Recurrence / Survival Analysis / Tissue Plasminogen Activator
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0167-5273(02)00186-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12208595; ● Search Scopus @ Elsevier (PMID): 12208595; ● Search Scopus @ Elsevier (DOI): 10.1016/S0167-5273(02)00186-9

(DOI: 10.1016/S0167-5273(02)00186-9, PubMed: 12208595) Takeshi Soeki, N Fukuda, H Shinohara, K Sakabe, Y Onose, Y Sawada and Y Tamura :
Mitral inflow and mitral annular motion velocities in patients with mitral annular calcification: evaluation by pulsed Doppler echocardiography and pulsed Doppler tissue imaging,
European Journal of Echocardiography, Vol.3, No.2, 128-134, 2002.

(要約): We evaluated the relationship between the mitral inflow velocities by pulsed Doppler echocardiography and mitral annular motion velocities by pulsed Doppler tissue imaging in patients with mitral annular calcification. Fifty-three patients with mitral annular calcification were divided into two groups: severe mitral annular calcification (n=15, mitral annular calcification bigger than or equal 5mm in width) and mild mitral annular calcification (n=38, mitral annular calcification <5mm in width). In addition, 20 patients with hypertensive heart disease (HHD group) and mild left ventricular hypertrophy but no mitral annular calcification and 30 normal individuals (normal group) were studied. The early diastolic mitral inflow velocity (E) was higher in the severe mitral annular calcification group (0.75+/-0.26 m/s) than in the HHD and normal groups (mild mitral annular calcification, 0.65+/-0.21; HHD, 0.57+/-0.24; normal, 0.55+/-0.15m/s), and the late diastolic mitral inflow velocity (A) was higher in the severe mitral annular calcification group (1.24+/-0.23 m/s) than in the other three groups (mild mitral annular calcification, 0.96+/-0.20; HHD, 0.84+/-0.23; normal, 0.75+/-0.13 m/s). In contrast, the early and late diastolic annular velocities (Ea, Aa) were lower in the severe mitral annular calcification group (Ea: 5.7+/-2.2; Aa: 11.9+/-4.4 cm/s) than in the other three groups (Ea: mild mitral annular calcification, 8.3+/-2.5; HHD, 7.7+/-2.2; normal, 9.0+/-1.8 cm/s; Aa: mild mitral annular calcification, 14.2+/-4.1; HHD, 14.3+/-2.8; normal, 14.2+/-2.1cm/s). Mitral valve area was smaller in the severe mitral annular calcification group (2.6+/-1.0 cm(2)) than in the other three groups (mild mitral annular calcification, 3.1+/-0.7; HHD, 4.1+/-0.7; normal, 4.2+/-0.9 cm(2)). In the mitral annular calcification and normal groups, the A correlated inversely with mitral valve area (r=-0.67, P<0.01) and directly with severity of mitral annular calcification (r=0.65, P<0.01), and the Ea correlated inversely with left ventricular wall thickness (r=-0.37, P<0.01) and severity of mitral annular calcification (r=-0.45, P<0.01). Patients with severe mitral annular calcification have higher mitral inflow velocities due to mitral annular restriction and lower mitral annular velocities caused by decreased mitral annular motion and abnormal left ventricular relaxation.
(キーワード): Aged / Blood Flow Velocity / Calcinosis / Coronary Circulation / Echocardiography, Doppler, Pulsed / Female / Heart Valve Diseases / Humans / Male / Middle Aged / Mitral Valve / Myocardial Contraction / Severity of Illness Index / Ultrasonography, Doppler, Pulsed
(出版サイトへのリンク): ● Publication site (DOI): 10.1053/euje.2001.0137
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12114097; ● Search Scopus @ Elsevier (PMID): 12114097; ● Search Scopus @ Elsevier (DOI): 10.1053/euje.2001.0137

(DOI: 10.1053/euje.2001.0137, PubMed: 12114097) Takeshi Soeki, Y Tamura, N Kondo, H Shinohara, H Tanaka, K Bando and N Fukuda :
A case of thyrotoxicosis with pancytopenia,
Endocrine Journal, Vol.48, No.3, 385-389, 2001.

(要約): We report a 49-year-old man with primary hyperthyroidism who presented with pancytopenia. The patient presented with leg edema, sinus tachycardia, cardiomegaly, and pleural effusions, all from congestive heart failure. Laboratory data showed pancytopenia and primary hyperthyroidism; echocardiogram showed diffuse hyperkinesis of the left ventricular wall and right ventricular overloading. The bone marrow was moderately hypercellular and compatible with arrested hematopoiesis. Pancytopenia and heart failure improved after administration of methimazole and diuretics. However, high levels of thyroid hormone recurred with pancytopenia 4 months after admission. Therefore, subtotal thyroidectomy was performed, and the levels of thyroid hormones and peripheral blood cell counts have remained normal. Pancytopenia may be caused by hyperthyroidism.
(キーワード): Antithyroid Agents / Blood Cell Count / Bone Marrow / Cardiomegaly / Diuretics / Edema / Heart Failure / Humans / Leg / Male / Methimazole / Middle Aged / Pancytopenia / Pleural Effusion / Recurrence / Tachycardia, Sinus / Thyroidectomy / Thyrotoxicosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1507/endocrj.48.385
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11523911; ● Search Scopus @ Elsevier (PMID): 11523911; ● Search Scopus @ Elsevier (DOI): 10.1507/endocrj.48.385

(DOI: 10.1507/endocrj.48.385, PubMed: 11523911) 篠原尚典, 福田信夫, 添木武, 田中英治, 板東完治, 田村禎通 :
肥大心における冠血流予備能の意義:ドップラー心エコー図指標，心内圧および血漿ナトリウム利尿ペプチド濃度との対比検討．,
Journal of Cardiology, Vol.37, No.1, 19-25, 2001年.

(要約): The relationship was investigated between coronary flow reserve and Doppler echocardiographic parameters, hemodynamic parameters and plasma natriuretic peptide concentrations in the hypertrophied heart. The subjects were 19 patients with hypertrophied heart due to various etiologies and no significant coronary artery stenosis. All patients were in sinus rhythm. The left ventricular wall thickness, the E/A ratio in transmitral flow velocity pattern and the Doppler index were determined by Doppler echocardiography, and the plasma atrial and brain natriuretic peptide concentrations were measured. At cardiac catheterization, pulmonary capillary wedge pressure and left ventricular end-diastolic pressure were measured, and the coronary flow reserve was obtained by injecting intracoronary adenosine triphosphate into the left anterior descending artery using a Doppler guidewire. Coronary flow reserve in the patients was significantly lower than in 11 normal control subjects (2.50 +/- 0.76 vs 3.90 +/- 0.64, p < 0.001). There were no significant correlations between coronary flow reserve and the left ventricular wall thickness or the E/A ratio. The mean value of the Doppler index in the patients was 0.48 +/- 0.10 and there was a significant negative correlation between coronary flow reserve and the Doppler index (r = -0.73, p < 0.001). The correlation between coronary flow reserve and left ventricular end-diastolic pressure was not significant, but there was a significant negative correlation between coronary flow reserve and pulmonary capillary wedge pressure (r = -0.64, p < 0.01). There were significant negative correlations between coronary flow reserve and atrial (r = -0.62, p < 0.01), or brain natriuretic peptide concentrations (r = -0.56, p < 0.05). Coronary flow reserve may reflect overall cardiac performance evaluated by the Doppler index and plasma natriuretic peptide concentrations in the hypertrophied heart, and the measurement of coronary flow reserve may be useful for evaluating disease severity in patients with hypertrophied heart.
(キーワード): Coronary circulation(coronary flow reserve) / Hypertrophy / Doppler ultrasound(Doppler index) / Natriuretic peptides / Hemodynamics
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11200652; ● CiNii @ 国立情報学研究所 (CRID): 1571698599545212800; ● Search Scopus @ Elsevier (PMID): 11200652

(PubMed: 11200652, CiNii: 1571698599545212800) Takeshi Soeki, Y Tamura, N Fukuda and Susumu Ito :
Plasma and platelet plasminogen activator inhibitor-1 in patients with acute myocardial infarction,
Japanese Circulation Journal, Vol.64, No.8, 547-553, 2000.

(要約): Several studies have demonstrated an increased level of plasma plasminogen activator inhibitor-1 (PAI-1) in patients with coronary artery disease (CAD). However, the concentration of PAI-1 in platelets, which accounts for more than 90% of the blood PAI-1, is unknown in these patients. The present study evaluated the concentrations of PAI-1 and several fibrinolytic factors in the plasma and platelets of patients with CAD and the serial changes in patients with acute myocardial infarction (AMI). All 72 subjects had coronary angiography and were divided into 3 groups: CAD(-) group without coronary artery stenosis or myocardial ischemia (n=20), CAD(+) group with either stable angina pectoris (n=18) or old myocardial infarction (n=12) with coronary artery stenosis, and the AMI group admitted within 24h of symptom onset who underwent successful percutaneous transluminal coronary angioplasty (n=22). The concentrations of plasma PAI-1, tissue plasminogen activator (t-PA), and t-PA x PAI-1 complex were similar in the CAD(-) and CAD(+) groups, but were greater on day 1 in the AMI group compared with the 2 CAD groups. There were no significant differences between the 3 groups in the plasma concentrations of thrombin antithrombin III complex (TAT), alpha2-plasmin inhibitor-plasmin complex (PIC), beta-thromboglobulin (beta-TG), and platelet factor 4 (PF-4). The platelet PAI-1 concentrations did not differ between the CAD(-) and CAD(+) groups, but was greater on day 1 in the AMI group compared to the CAD groups. The platelet beta-TG and PF-4 were similar between the 3 groups. In the AMI group, both the plasma and platelet PAI-1 concentrations were greater on day 1, but the plasma PAI-1 rapidly decreased by day 5 and remained low on day 28 compared with day 1. The platelet PAI-1 concentration gradually decreased by day 5 and was further decreased by day 28. The serial changes of the plasma t-PA and t-PA PAI-1 complex during the course of AMI were similar to those of the plasma PAI-1. A positive correlation was found between the plasma and platelet PAI-1 in all 72 patients, but not in the AMI group alone. These results suggest that the PAI-1 that has accumulated in platelets at the onset of AMI might be released in large amounts into the plasma, resulting in an increase in thrombus formation.
(キーワード): Aged / Antifibrinolytic Agents / Antithrombin III / Biomarkers / Blood Coagulation Factors / Blood Platelets / Cohort Studies / Coronary Disease / Female / Fibrinolysin / Fibrinolytic Agents / Humans / Male / Middle Aged / Myocardial Infarction / Peptide Hydrolases / Plasminogen Activator Inhibitor 1 / Platelet Activating Factor / Platelet Factor 4 / Time Factors / Tissue Plasminogen Activator / alpha-2-Antiplasmin / beta-Thromboglobulin
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10952148; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033850676

(PubMed: 10952148, Elsevier: Scopus) K Bando, N Fukuda, H Shinohara, N Takeichi, Takeshi Soeki, H Tanaka and Y Tamura :
Pulmonary venous flow velocity patterns in sinus rhythm and atrial fibrillation : the difference between the right and left pulmonary veins,
Journal of Medical Ultrasonics, Vol.27, 1131-1138, 2000. Takeshi Soeki, Y Tamura, H Shinohara, H Tanaka, K Bando and N Fukuda :
Serial changes in serum VEGF and HGF in patients with acute myocardial infarction,
Cardiology, Vol.93, No.3, 168-174, 2000.

(要約): The time course of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) release in patients with acute myocardial infarction (AMI) is unknown. Blood samples were obtained at the time of admission and 3, 7, 14 and 21 days later in 32 patients with AMI and 30 control patients. Serum VEGF and HGF, as well as C-reactive protein (CRP) and amyloid A protein (SAA), were determined. Both serum VEGF and HGF levels on admission in patients with AMI were higher than control values and peaked on day 7. VEGF levels in patients with preinfarction angina were higher than in patients with no preinfarction angina, whereas the HGF level did not differ. Both CRP and SAA levels peaked on day 3, and the CRP level on day 3 correlate with both VEGF and HGF levels on day 7. We hypothesized that the serum VEGF level is associated with preinfarction ischemia and the increase in VEGF and HGF on day 7 of AMI may represent a response to acute inflammation.
(キーワード): Aged / Angioplasty, Balloon, Coronary / Biomarkers / Coronary Angiography / Creatine Kinase / Electrocardiography / Endothelial Growth Factors / Female / Hepatocyte Growth Factor / Humans / Lymphokines / Male / Middle Aged / Myocardial Infarction / Prognosis / Protein Isoforms / Recurrence / Risk Factors / Vascular Endothelial Growth Factor A / Vascular Endothelial Growth Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000007022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10965088; ● Search Scopus @ Elsevier (PMID): 10965088; ● Search Scopus @ Elsevier (DOI): 10.1159/000007022

(DOI: 10.1159/000007022, PubMed: 10965088) Takeshi Soeki, Y Tamura, H Shinohara, H Tanaka, K Bando and N Fukuda :
Role of circulating vascular endothelial growth factor and hepatocyte growth factor in patients with coronary artery disease,
Heart and Vessels, Vol.15, No.3, 105-111, 2000.

(要約): Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are thought to stimulate endothelial cell proliferation and induce angiogenesis in vivo. However. the precise mechanism responsible for VEGF and HGF release in patients with coronary artery disease is still unknown. We studied serum concentrations of VEGF and HGF in 20 patients with acute myocardial infarction (AMI), 20 patients with stable angina pectoris (AP) who had reversible perfusion defects on stress myocardial scintigraphy, and 16 patients with old myocardial infarction (OMI) who had no reversible defects on stress myocardial scintigraphy. The control group consisted of 20 patients with atypical chest pain who had angiographically normal coronary arteries. Serum VEGF and HGF concentrations were measured by enzyme-linked immunosorbent assay. Both the serum VEGF and HGF concentrations in the early stage of myocardial infarction in the patients with AMI were higher than those in the patients with AP and with OMI, and control patients. The VEGF concentration in the patients with AP was higher than in the patients with OMI, whereas the HGF concentration did not differ in the patients with AP and OMI. The VEGF concentration in AMI patients who had had preinfarction angina on admission was higher than that of patients who had had no preinfarction angina, whereas the HGF concentration did not differ between the two groups of patients. These results suggest that the serum VEGF concentration may reflect myocardial ischemia to a greater degree than the serum HGF concentration.
(キーワード): Aged / Aged, 80 and over / Angina Pectoris / Biological Markers / Coronary Angiography / Coronary Disease / Endothelial Growth Factors / Female / Follow-Up Studies / Hepatocyte Growth Factor / Humans / Lymphokines / Male / Middle Aged / Myocardial Infarction / Probability / Radioimmunoassay / Radionuclide Imaging / Reference Values / Sensitivity and Specificity / Severity of Illness Index / Thallium / Vascular Endothelial Growth Factor A / Vascular Endothelial Growth Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11289497; ● Search Scopus @ Elsevier (PMID): 11289497

(PubMed: 11289497) Takeshi Soeki, Y Tamura, H Shinohara, H Tanaka, K Bando, Y Yui and N Fukuda :
Fibrinolytic factors, serum lipid and C-reactive protein predicting cardiac events in Japanese patients with coronary atherosclerotic lesions,
Japanese Circulation Journal, Vol.63, No.12, 976-980, 1999.

(要約): Although disturbances of the fibrinolytic system and serum lipid, and the presence of inflammation, may be risk factors for coronary artery disease (CAD), few reports have investigated these relationships in Japanese patients. Data on 106 patients (79 men and 27 women, mean age 62.3 years) with atherosclerotic lesions on the coronary angiogram were evaluated prospectively to identify whether the factors were useful in predicting the risk of coronary events during a follow-up of 50+/-4 months. Of the 106 patients who were followed, 11 patients had coronary events (4 acute myocardial infarction and 7 unstable angina pectoris). In univariate Cox analyses, a high level of tissue-plasminogen activator (t-PA), apolipoprotein CII, C-reactive protein (CRP), and a low level of high-density lipoprotein-cholesterol (HDL-C) was each associated with a significant increase in the risk of future cardiac events. The stepwise model of Cox proportional hazards analysis selected only a high level of t-PA and CRP as predictors of cardiac events. Controlling for any risk factor did not lower the relation between t-PA and the risk of cardiac events, whereas the relative risk of cardiac events in CRP was not significant when controlled for HDL-C. Thus, in prospective data obtained from a cohort of Japanese patients with coronary atherosclerotic lesions, the elevation of t-PA was an independent predictor of subsequent cardiac events. The prognostic role of CRP in cardiac events was related to a low level of HDL-C.
(キーワード): Angina Pectoris / Apolipoprotein C-II / Apolipoproteins C / Asian Continental Ancestry Group / C-Reactive Protein / Cholesterol, HDL / Coronary Artery Disease / Female / Humans / Japan / Male / Middle Aged / Myocardial Infarction / Prognosis / Prospective Studies / Risk Factors / Tissue Plasminogen Activator
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10614844; ● Search Scopus @ Elsevier (PMID): 10614844

(PubMed: 10614844) 武市直樹, 福田信夫, 篠原尚典, 添木武, 田中英治, 板東完治, 由井靖子, 田村禎通 :
経胸壁心エコー法による左心耳血流の検出:経食道法との比較検討．,
医学のあゆみ, Vol.188, 287-288, 1999年. H Shinohara, N Fukuda, Takeshi Soeki, N Takeichi, Y Yui, Y Tamura and T Oki :
Relationship between flow dynamics in the left atrium and hemostatic abnormalities in patients with nonvalvular atrial fibrillation,
Japanese Heart Journal, Vol.39, No.6, 721-730, 1998.

(要約): To investigate the relationship between left atrial (LA) flow dynamics and hemostatic markers in nonvalvular atrial fibrillation (AF), 45 patients with nonvalvular AF who had not received anticoagulants were evaluated by transesophageal echocardiography. We determined the LA appendage flow and the presence of LA spontaneous echo contrast (SEC) or thrombus. We measured plasma levels of thrombin-antithrombin III complex (TAT), fibrinopeptide A, D-dimer, beta-thromboglobulin, and platelet factor 4 in peripheral blood as hemostatic markers. The patients were divided into a low-velocity group (n = 19; sum of peak emptying and filling LA appendage flow velocities < 40 cm/s) and a high-velocity group (n = 26; > or = 40 cm/s). The maximum LA diameter was significantly greater and the LA expansion fraction was significantly smaller in the low-velocity group than in the high-velocity group. LA SEC or thrombus was observed in 11 patients (58%) in the low-velocity group, but not in any patients in the high-velocity group (p < 0.001). The plasma levels of TAT, fibrinopeptide A, D-dimer, beta-thromboglobulin, and platelet factor 4 were significantly higher in the low-velocity group than in the high-velocity group. The plasma levels of TAT, fibrinopeptide A, beta-thromboglobulin, and platelet factor 4 were significantly higher in 8 patients without LA SEC or thrombus in the low-velocity group than in 26 patients in the high-velocity group. Patients with nonvalvular AF accompanied by an enlarged and dysfunctioning LA and a decreased LA appendage flow velocity had increased intravascular coagulation-fibrinolysis activity and platelet activation. These abnormalities may be closely related to the thrombogenetic state in patients with nonvalvular AF.
(キーワード): Adult / Aged / Aged, 80 and over / Antithrombin III / Atrial Fibrillation / Atrial Function, Left / Biomarkers / Blood Coagulation / Blood Flow Velocity / Echocardiography, Transesophageal / Female / Fibrinolysis / Fibrinopeptide A / Hemodynamics / Hemostasis / Humans / Male / Middle Aged / Peptide Hydrolases / Platelet Factor 4 / beta-Thromboglobulin
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10089934; ● Search Scopus @ Elsevier (PMID): 10089934

(PubMed: 10089934) Takeshi Soeki, Y Tamura, K Bando, H Tanaka, N Takeichi, H Shinohara, Y Yui, N Fukuda and O Sui :
Long-term effects of the angiotensin-converting enzyme inhibitor enalapril on chronic heart failure. Examination by 123I-MIBG imaging,
Japanese Heart Journal, Vol.39, No.6, 743-751, 1998.

(要約): To examine the long-term effects of the angiotensin-converting enzyme (ACE) inhibitor enalapril on chronic heart failure, 10 patients (7 men and 3 women, mean age: 62 +/- 11 years) with chronic stable heart failure, classified as New York Heart Association (NYHA) functional class 2-3 for more than 3 months, and a left ventricular ejection fraction less than 45% were treated with 2.5-5.0 mg of enalapril once a day for 3-15 months (mean 7 months). The causes of heart failure were old myocardial infarction (n = 7), hypertension (n = 2), and atrial fibrillation (n = 1). Radioiodinated metaiodobenzyl guanidine (123I-MIBG) imaging, radionuclide angiography, and treadmill exercise test were performed before and after the treatment. With enalapril treatment, (1) left ventricular ejection fraction (LVEF) increased significantly from 38.3 +/- 6.9% to 47.5 +/- 14.7%; (2) sub-maximal exercise time increased significantly from 205 +/- 112 to 272 +/- 120 seconds; (3) the heart to mediastinum (H/M) ratio of 123I-MIBG increased significantly (early image: 1.99 +/- 0.38 versus 2.20 +/- 0.50; delayed image: 1.86 +/- 0.44 versus 2.09 +/- 0.51); and (4) the washout rate of 123I-MIBG decreased slightly from 29.1 +/- 9.1% to 25.4 +/- 7.0%. The improvement rate of LVEF was significantly correlated with the improvement rates of the H/M ratio and washout rate after treatment with enalapril. Thus, the long-term effects of enalapril can be observed in the cardiac sympathetic nervous system, and 123I-MIBG imaging appears to be useful for evaluating the therapeutic effects of enalapril on the cardiac sympathetic nervous system in patients with chronic heart failure.
(キーワード): 3-Iodobenzylguanidine / Aged / Angiotensin-Converting Enzyme Inhibitors / Antihypertensive Agents / Atrial Fibrillation / Chronic Disease / Enalapril / Female / Heart Failure / Humans / Hypertension / Iodine Radioisotopes / Male / Middle Aged / Myocardial Infarction / Radionuclide Imaging / Radiopharmaceuticals / Stroke Volume / Ventricular Function, Left
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10089936; ● Search Scopus @ Elsevier (PMID): 10089936

(PubMed: 10089936) 添木武, 田村禎通, 武市直樹, 篠原尚典, 由井靖子, 福田信夫, 須井修 :
急性心筋梗塞におけるplasminogen activator inhibitor-1(PAI-1) と梗塞サイズとの関係．,
呼吸と循環, Vol.46, No.5, 483-487, 1998年. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, N Takeichi, H Shinohara, Takeshi Soeki, Y Yui and Y Tamura :
Right heart flow dynamics after tricuspid valve annuloplasty. Characteristics and time course,
Japanese Heart Journal, Vol.39, No.3, 339-346, 1998.

(要約): To evaluate the effect of tricuspid annuloplasty (TAP) on right heart flow dynamics, we analyzed tricuspid inflow velocity pattern, jugular venous pulse and color Doppler flow signal of tricuspid regurgitation (TR) before and after surgery in 16 patients who underwent TAP (TAP group). Cardiac rhythm was atrial fibrillation in all patients. Twelve patients with lone atrial fibrillation served as controls (AF group). Patients in the TAP group were studied before and serially after surgery with a mean follow-up period of 2.7 years. TAP was performed according to the modified De Vega technique in all patients. In a comparison of the most recent data in the TAP group and the data in the AF group, the maximum tricuspid inflow velocity was significantly increased, and both the deceleration time of the tricuspid inflow velocity wave and the y-h interval of the jugular venous pulse were significantly prolonged in the TAP group compared to the AF group. Immediately after surgery, in the TAP group, the area of the TR jet was markedly decreased, and the deceleration time of the tricuspid inflow velocity wave was significantly prolonged compared to those before surgery. The area of the TR jet was dramatically decreased and remained small during the follow-up period. Thus, TAP may produce mild tricuspid stenosis but may also confer sustained preventive effects against TR.
(キーワード): Adult / Aged / Echocardiography, Doppler, Color / Heart / Humans / Jugular Veins / Middle Aged / Postoperative Period / Pulse / Tricuspid Valve / Tricuspid Valve Insufficiency
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9711185; ● Search Scopus @ Elsevier (PMID): 9711185

(PubMed: 9711185) H Shinomiya, N Fukuda, N Takeichi, Takeshi Soeki, H Shinohara, Y Yui, Y Tamura and T Oki :
Echocardiographic assessment of right atrial function in patients with myocardial infarction with reference to obstructive lesions of the coronary arteries,
Japanese Circulation Journal, Vol.62, 393-398, 1998. N Fukuda, T Oki, A Iuchi, Tomotsugu Tabata, Hirotsugu Yamada, Susumu Ito, N Takeichi, H Shinohara, Takeshi Soeki, H Shinomiya, Y Yui and Y Tamura :
Tricuspid inflow and regurgitant flow dynamics after mitral valve replacement: Differences relating to surgical repair of the tricuspid valve,
The Journal of Heart Valve Disease, Vol.6, No.2, 184-188, 1997.

(要約): Changes in tricuspid inflow and regurgitant flow dynamics were evaluated in patients with functional tricuspid regurgitation (TR) who underwent mitral valve replacement (MVR) with and without tricuspid annuloplasty (TAP). In a group of 30 patients, all with atrial fibrillation, 15 underwent TAP performed according to the modified De Vega technique; the remaining 15 did not undergo TAP. Patients were studied before and serially after surgery, using pulsed and color Doppler echocardiography. The mean follow up was 4.7 years in the TAP group and 5.1 years in the non-TAP group. In the TAP group, immediately after surgery, the area of the TR jet decreased markedly, and the deceleration time of the tricuspid inflow velocity wave was significantly prolonged compared with that before surgery. By contrast, in the non-TAP group, both the area of the TR jet and deceleration time of tricuspid inflow velocity were virtually unchanged. The area of the TR jet remained small for a long period in the TAP group, but in non-TAP patients was increased in four cases over seven years, with two patients developing right-sided heart failure. Recent data showed the area of the TR jet to be significantly smaller, with maximum tricuspid inflow velocity significantly increased, and deceleration time of the tricuspid inflow velocity wave significantly prolonged in the TAP group compared with the non-TAP group. In patients with functional tricuspid regurgitation undergoing MVR, concomitant TAP may cause mild tricuspid stenosis, but produces sustained preventive effects against TR. Careful follow up is needed in patients who have not undergone TAP, as TR is not markedly decreased and may even be exacerbated. Aggressive TAP is recommended in patients showing dilatation of the tricuspid annulus, even if TR is mild.
(キーワード): Adult / Aged / Echocardiography, Doppler, Color / Female / Heart Valve Prosthesis / Hemodynamics / Humans / Male / Middle Aged / Mitral Valve / Mitral Valve Stenosis / Postoperative Complications / Prognosis / Treatment Outcome / Tricuspid Valve Insufficiency
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9130130; ● Search Scopus @ Elsevier (PMID): 9130130

(PubMed: 9130130) 由井靖子, 田村禎通, 岩野健造, 石田孝敏, 小田修治, 岩本正博, 添木武, 久保謙一郎, 長町典夫, 木村光宏 :
妊娠の循環動態:左室収縮時間および色素希釈法による心拍出量についての検討．,
医療, Vol.49, No.9, 732-737, 1995年. 須井修, 木村なづな, 添木武, 武市直樹, 篠原尚典, 田村禎通, 福田信夫 :
虚血性心疾患の診断におけるタリウム負荷心筋SPECTの有用性の検討．,
医療, Vol.51, No.5, 210-214, 1995年.

MISC

T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
Circulation Journal, Vol.72, No.0, 715_OJ233, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698602189478144

(CiNii: 1571698602189478144) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
Circulation Journal, Vol.72, No.0, 249_FRS022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543027118467968

(CiNii: 1572543027118467968) Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
Circulation Journal, Vol.72, No.0, 632_PE499, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105977073314048

(CiNii: 1573105977073314048) Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
Circulation Journal, Vol.72, No.0, 145_OE022, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571135652234960512

(CiNii: 1571135652234960512) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
Circulation Journal, Vol.72, 421_PJ456, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824502094771072

(CiNii: 1572824502094771072) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume does not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, 508_PE367, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570009752328732544

(CiNii: 1570009752328732544) Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Circulation Journal, Vol.72, 426_PJ492, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141358592

(CiNii: 1572261552141358592) Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
Circulation Journal, Vol.72, No.0, S_749, 2008.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261552141499008

(CiNii: 1572261552141499008) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
Circulation, Vol.118, S_749, 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
Circulation, Vol.118, S_651, 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
Eur Heart J, Vol.29, 505-732, 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
Eur Heart J, Vol.29, 505-732, 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, H Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
Eur Heart J, Vol.29, 505-732, 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 550, 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 545, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.21, 543, 2008. Kenya Kusunose, K Takechi, Hirotsugu Yamada, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku and Y Maeda :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study).,
Journal of the American Society of Echocardiography, Vol.21, 538, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.21, 524, 2008. Hirotsugu Yamada, Kenya Kusunose, Y Uzuuchi, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the cardiac response to increment of preload in patients with atrial fibrillation using dual pulsed Doppler echocardiography.,
Journal of the American Society of Echocardiography, Vol.20, 594, 2007. Kenya Kusunose, Hirotsugu Yamada, T Chono, H Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, K Aihara and Hiromu Nishitani :
Measurement of left atrial volume curve by advanced 2D tissue tracking technique: validation by contrast multidetector computed tomography.,
Journal of the American Society of Echocardiography, Vol.20, 603, 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early Diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
Journal of the American College of Cardiology, Vol.49, No.9, 137A, 2007. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Effect of aging on left atrial myocardial strain evaluated by 2D tissue tracking during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Differentiation of left atrial dysfunction by changes in transmitral flow velocities during lower body positive pressure.,
Journal of the American Society of Echocardiography, Vol.19, 613, 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
Journal of the American College of Cardiology, Vol.47, No.4A, 308A, 2006. Kenya Kusunose, Hirotsugu Yamada, Yoshihito Saijo, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography for the Assessment of Heart Failure With Preserved Ejection Fraction,
JACC. Cardiovascular Imaging, Vol.15, No.2, 375-378, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2021.09.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34656477; ● Search Scopus @ Elsevier (PMID): 34656477; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2021.09.005

(DOI: 10.1016/j.jcmg.2021.09.005, PubMed: 34656477)

総説・解説

伊勢孝之, 高木恵理, 岩瀬俊, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
日本内科学会雑誌, Vol.104, No.6, 1175-1179, 2015年.

(要約): 心臓サルコイドーシスの標準的治療はステロイドであるが，ステロイドを投与中であっても再燃を認めることも多く，またステロイドの多岐にわたる副作用も問題となることが多い．症例は70歳代，女性．心臓サルコイドーシスの診断でプレドニンを維持量5 mg/日で加療されていた．定期検査で施行した心電図で陰性T波，前壁心尖部に新規の左室壁運動異常を認めた．FDG-PET，Gaシンチグラフィーで壁運動異常部位に一致して集積を認め，心臓サルコイドーシスの再燃と判断した．本症例では，ステロイドの副作用として糖尿病，肥満，白内障などを認めており，ステロイド増量が躊躇され，メトトレキサートの併用を開始した．メトトレキサート開始後，特に副作用を認めず，心電図ならびに左室壁運動異常の改善が認められた．ステロイド投与で再燃を認める心臓サルコイドーシス症例にはメトトレキサート併用も考慮すべきであると考えられた．
(キーワード): 心臓サルコイドーシス / 再燃 / ステロイド (steroid) / メトトレキサート / 副作用
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/naika.104.1175
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001206449318272; ● Search Scopus @ Elsevier (DOI): 10.2169/naika.104.1175

(DOI: 10.2169/naika.104.1175, CiNii: 1390001206449318272) 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性(第11回若手奨励賞受賞論文),
四国医学雑誌, Vol.70, No.3, 4, 87-92, 2014年8月.

(要約): 【Background】 Percutaneous transluminal renal angioplasty (PTRA) is recommended for patients with heart failure due to renovascular hypertension ; however, the clinical characteristics of the patients and the effects of PTRA on heart failure and cardiorenal function have not been elucidated. 【Methods】 We retrospectively analyzed data for 4 PTRA-treated patients (male/female, 1/3 ; mean age, 70.0±10 years ; mean left ventricular ejection fraction, 51.5±15.2%) with heart failure due to renovascular hypertension and evaluated the effects of PTRA on heart failure and cardiorenal function 6 months after treatment. 【Results】 All patients had pro-arteriosclerotic diseases including diabetes mellitus, essential thrombocythemia, heparin cofactor II deficency, metabolic syndrome, and familial hypercholesterolemia, and 3 patients had ischemic heart disease. No abdominal bruit was heard and mean plasma renin activity was 4.5±3.6 ng/ml/hr, which was not elevated, contrary to expectation. All contralateral kidneys of PTRA were nonfunctioning, suggesting bilateral kidneys were disturbed in all patients. In all patients, PTRA was successfully performed and resolved heart failure. PTRA resulted in decreases in systolic blood pressure from 157±18 to 124±8.6 mmHg, mean serum creatinine from 3.2±2.6 to 2.7±2.2 mg/dl, and mean BNP from 919±998 to 243±291 pg/ml at 6 months after treatment. PTRA did not change left ventricular ejection fraction, a parameter of systolic fraction evaluated by an echocardiogram ; however, PTRA improved E/e', a parameter of left ventricular diastolic fraction, from 16.1±5.2 to 9.7±3.7. None of the patients were hospitalized due to heart failure during the 6-month period after PTRA. 【Conclusions】 Patients with heart failure with cardiovascular risk factors should be screened for renovascular hypertension regardless of abdominal bruit or plasma renin activity. PTRA is effective for resolving heart failure and for improving renal and cardiac diastolic functions in patients with renovascular hypertension complicated with heart failure.
(キーワード): heart failure / cardiac disturbance syndrome / percutaneous transluminal renal angioplasty
(徳島大学機関リポジトリ): ● Metadata: 109759
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001337734629888

(徳島大学機関リポジトリ: 109759, CiNii: 1050001337734629888) Takeshi Soeki :
Ghrelin and its receptor: the role of the ghrelin signaling system in regulating cardiac function.,
Regulatory Peptides, Vol.192-193, 57-58, Jun. 2014.

(キーワード): Animals / Coronary Vessels / Ghrelin / Male / Receptors, Ghrelin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.regpep.2014.08.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25176326; ● Summary page in Scopus @ Elsevier: 2-s2.0-84908093810

(DOI: 10.1016/j.regpep.2014.08.004, PubMed: 25176326, Elsevier: Scopus) 添木武, 佐田政隆 :
高血圧の炎症・免疫バイオマーカー,
血圧, Vol.20, No.11, 30-34, 2013年11月.

(キーワード): 高感度CRP / 炎症性サイトカイン (inflammatory cytokine) / PTX3 / アディポネクチン / micro RNA

八木秀介, 福田大受, 添木武, 島袋充生, 佐田政隆 :
RAS研究 -ラボの最前線- 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学・心臓血管病態医学,
Angiotensin Research, Vol.10, No.1, 59-63, 2013年1月. 添木武, 木谷光宏, 佐田政隆 :
循環器専門医が考えるCa拮抗薬の選択ポイント(動脈硬化),
循環Plus, Vol.12, No.8, 7-9, 2012年5月. 山田博胤, 楠瀬賢也, 西尾進, 添木武, 佐田政隆 :
循環器病診療における最新の診かた，考え方心房細動と塞栓症-何時，どのような治療を始めるか?-,
四国医学雑誌, Vol.66, No.3, 63-70, 2010年8月.

(要約): Atrial fibrillation(AF)is a common arrhythmia and the prevalence of this arrhythmia is increasing as aging. Secondary AF is defined as AF with organic heart disease and lone AF as AF without it. The AF is divided into paroxysmal, persistent and chronic by its onset and persistence. It is clinically important that any type AF causes thromboembolic stroke. The preventive Qumadin therapy should be applied to patients with AF. Transesophageal echocardiography has been utilized for the diagnosis of left atrial thrombus and for the prediction of stroke. CHADS2 score is a clinical prediction rule for estimating the risk of stroke in patients with non-rheumatic AF. Patients with CHADS2 score_1should be treated with Qumadin. Rhythm control and rate control are two different strategies for the treatment of AF. There is no evidence that indicate better choice between rhythm control and rate control. Recently, inhibitors of the renin-angiotensin system have a potential to prevent new onset of AF in patients who has risk factors.
(キーワード): atrial fibrillation / thrombosis / stroke / transesophageal echocardiography / qumadin
(徳島大学機関リポジトリ): ● Metadata: 110316
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762395229952

(徳島大学機関リポジトリ: 110316, CiNii: 1050845762395229952) 田村禎通, 添木武, 篠原尚典, 酒部宏一, 小野瀬由紀子, 福田信夫 :
虚血性心疾患患者の心血管事故発生の予測因子,
臨床と研究, Vol.78, 1648-1652, 2001年. 添木武, 福田信夫 :
心血管疾患各論 1)弁膜症 (2)大動脈弁膜症,
臨床検査, Vol.45, 1351-1355, 2001年. 田村禎通, 添木武 :
虚血性心疾患の危険因子としての線溶系,
医療, Vol.54, No.12, 551-560, 2000年12月.

講演・発表

Kohei Nagano, Tomonori Takahashi, Tetsuzo Wakatsuki, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-Term Outcome of Stentless Coronary Intervention With Drug-Coated Balloon in Patients With High Bleeding Risk,
AHA2023, Philadelphia, Nov. 2023. N Yamaguchi, Kenya Kusunose, Yukina Hirata, Susumu Nishio, Tomonori Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Improved Pressure-Flow Relationship With Sacubitril/Valsartan: A 6-min Walk Stress Echocardiographic Study,
AHA2023, Philadelphia, Nov. 2023. Yosuke Kaneko, Saya Yasui, Minae Hosoi, Akihiro Tani, Hiroki Yamagami, Hiroyasu Mori, Tomoyo Hara, Yukari Mitsui, Kiyoe Kurahashi, Sumiko Yoshida, Shingen Nakamura, Akio Kuroda, Toshiki Otoda, Tomoyuki Yuasa, Itsuro Endo, Takeshi Soeki, Munehide Matsuhisa, Masahiro Abe and Ken-ichi Aihara :
Dehydroepiandrosterone sulfate and skeletal muscle disorders in patients with type 2 diabetes,
IDF-WPR Congress 2023/15th Scientific Meeting of AASD, Tokyo, Jul. 2023. Akihiro Tani, Takeshi Soeki, Yuji Ozaki, Ken-ichi Aihara and Masataka Sata :
Impact of Sarcopenia and Atrial Fibrillation on the Incidence of Heart Failure in Elderly Patients,
The 29th Scientific Meeting of the International Society of Hypertension, Oct. 2022. Y Okushi, Kenya Kusunose, Hiromitsu Seno, Tomonori Takahashi, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
The Impact of Surveillance of Cancer Therapeutics-Related Cardiac Dysfunction by Periodic Echocardiography,
ASE2022, Seattle, Jun. 2022. Koji Yamaguchi, Tetsuzo Wakatsuki, Y Okushi, Kumiko Suto, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and chronic phased local coagulative responses following bioresorbable-polymer drug-eluting stent implantation,
European Heart Journal, Vol.42, No.S1, ehab724.1245, Aug. 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/eurheartj/ehab724.1245
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/eurheartj/ehab724.1245

(DOI: 10.1093/eurheartj/ehab724.1245) Miharu Arase, Kenya Kusunose, Sae Morita, N Yamaguchi, Yukina Hirata, Susumu Nishio, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Noninvasive Assessment of Flow-pressure Relationship in Scleroderma,
American Heart Associeition, Dallas, Nov. 2020. Y Okushi, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differences ofCancer Types in Hospital Mortality in Patients With Venous Thromboembolism,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.13145
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.13145

(DOI: 10.1161/circ.142.suppl_3.13145) Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Suppressed Local Coagulative Response After Newer-generation Ultrathin Strut SES Implantation Compared to Older-generation SES Implantation,
American Heart Association, Dallas, Nov. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1161/circ.142.suppl_3.12894
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1161/circ.142.suppl_3.12894

(DOI: 10.1161/circ.142.suppl_3.12894) Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Toll-like receptor 9 is a novel therapeutic target to prevent atrial fibrillation,
European Heart Journal, Vol.41, No.S2, ehaa946.0463, Aug. 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ehjci/ehaa946.0463
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/ehaa946.0463

(DOI: 10.1093/ehjci/ehaa946.0463) Kenya Kusunose, Nishio Susumu, Hirata Yukina, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pulmonary Artery Hypertension Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension,
JACC. Cardiovascular Imaging, Vol.12, No.12, 2576-2579, Dec. 2019.

(キーワード): Adult / Aged / Antihypertensive Agents / Arterial Pressure / Disease Progression / Echocardiography, Stress / Exercise / Exercise Tolerance / Female / Humans / Male / Middle Aged / Progression-Free Survival / Prospective Studies / Pulmonary Arterial Hypertension / Pulmonary Artery / Recovery of Function / Time Factors / Vasodilator Agents / Walk Test
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2019.07.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31422131; ● Search Scopus @ Elsevier (PMID): 31422131; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2019.07.002

(DOI: 10.1016/j.jcmg.2019.07.002, PubMed: 31422131) Yutaka Kawabata, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki and Masataka Sata :
The relationship among local epicardial adipose tissue, coronary intraplaque microluminal structure, and coronary plaque formation -a fresh cadaveric study,
AHA2019, Philadelphia, Nov. 2019. Yukina Hirata, Masataka Sata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, nao Yamada, Koji Yamaguchi, Takeshi Soeki and Tetsuzo Wakatsuki :
Usefulness of echocardiographic epicardial adipose tissue thickness for predicting coronary artery disease regardless of body mass index,
AHA2019, Philadelphia, Nov. 2019. B Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
S1p2 Receptor Antagonist Attenuates Endothelial Dysfunction And Inhibits Atherogenesis In Apolipoprotein-e-deficient Mice,
AHA2019, Philadelphia, Nov. 2019. Sutou Kumiko, Daiju Fukuda, B Ganbaatar, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Pemafibrate, a novel selective peroxisome proliferator-activated receptor-a modulator, ameliorated diabetes-induced endothelial dysfunction,
AHA2019, Philadelphia, Nov. 2019. A Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 inhibitor, attenuates endothelial dysfunction and atherogenesis independent of its glucose lowering effect in apolipoprotein e-deficient mice,
AHA2019, Philadelphia, Nov. 2019. Byambasuren Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Empagliflozin, a SGLT2 inhibitor, attenuates endothelial dysfuntion and atherogenesis by inhibiting inflammatory responses in the vasculature and adipose tissue in disbetic apolipoprotein E-deficient,
ESC Congress 2019, Paris, Sep. 2019. Takeshi Soeki, Kazuhisa Matsumoto, Daiju Fukuda, 植松悦子, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Vildagliptin reduces inducitiligy of arterial fibrillation in hypertensive rats complicated with diabetes mellitus,
ESC Congress 2019, Paris, Sep. 2019. Koji Yamaguchi, Tetsuzo Wakatsuki, Rie Ueno, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The improvement of chronic local coagulative response according to the progress of drug eluting stent,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Yukina Hirata, Susumu Nishio, nao Yamada, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Impact of epicardial adipose tissue on global longitudinal strain: a study in patients with normal left ventricular ejection fraction,
ESC Congress 2019, Paris, Sep. 2019. Maimaituxun Gulinu, Daiju Fukuda, Shusuke Yagi, Shoichiro Takao, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Adipose tissue surrounding the kidney and its impact on coronary artery disease,
ESC Congress 2019, Paris, Sep. 2019. Rahadian Arief, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Glycemic control with canagliflozin, a SGLT-2 inhibitor, attenuates atherosclerosis and endothelial dysfuntion in diabetic apolipoprotein e-deficient mice,
ESC Congress 2019, Paris, Aug. 2019. Phuong Tran Pham, D Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling,
AHA, Chicago, Nov. 2018. Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice,
AHA, Chicago, Nov. 2018. Y Saijo, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension,
AHA, Chicago, Nov. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, O Harada, N Miyazato, A Haraguni, A Ito, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease,
AHA, Chicago, Nov. 2018. Ganbaatar Byambasuren, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice,
ESC2018, Munich, Aug. 2018. Takeshi Soeki, E Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias.,
ESC2018, Munich, Aug. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers,
ESC2018, Munich, Aug. 2018. Ganbaatar Byambasuren, Daiju Fukuda, HM Salim, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice,
ESC2018, Munich, Aug. 2018. Maimaituxun Gulinu, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease,
ESC2018, Munich, Aug. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, R Shimizu, Yuta Torii, Susumu Nishio, Y Okushi, Hiromitsu Seno, Y Saijo, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
EACVI meeting 2018, Dec. 2017. Y. Hirata, Kenya Kusunose, Hirotsugu Yamada, J. Kuwahata, R. Shimizu, Y. Torii, R. Amano, M. Yamao, S. Nishio, H. Seno, Y. Saijo, Takeshi Soeki and Masataka Sata :
Association between left atrial appendage morphology and stroke in atrial fibrillation: comparison between quantitative and visual classification,
Euro Echo 2017, Portugal, Dec. 2017. Takeshi Soeki, Tomomi Matsuura, E Uematsu, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Maimaituxun. Gulinu, Michio Shimabukuro, Y Hirata, Takashi Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Harada and Masataka Sata :
Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease,
AHA Scientific Sessions2017, California, America, Nov. 2017. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Torii, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low Gradient Aortic Stenosis,
AHA Scientific Sessions2017, California, America, Nov. 2017. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
AHA Scientific Sessions2017, California, America, Nov. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, H Ito, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response After Biodegradable Polymer SES Implantation Compared to Durable Polymer SES,
AHA Scientific Sessions2017, California, America, Nov. 2017. Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, R Kato, M Hara, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Direct Slow Pathway Capture: A New Electrophysiological Method of Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia,
AHA Scientific Sessions2017, California, America, Nov. 2017. Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, H Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Epicardial Adipose Tissue Thickness is a Marker for the Detection of Vasospastic Angina,
ASE2017, Baltimore, Jun. 2017. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Y Hirata, Hiromitsu Seno, Y Saijo, Takayuki Ise, Koji Yamaguchi, Shuusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity,
ASE2017, Baltimore, Jun. 2017. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, R Shimizu, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Y Saijo, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Age on the Morphology of Left Atrial Appendage I Atrial Fibrillation,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, Y Saijo, H Seno, Y Hirata, Y Torii, S Nishio, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients With Tachycardia-induced Cardiomyopathy,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. HMM Salim, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Dabigatran, a direct thrombin inhibitor, prevents the development of endothelial dysfunction in diabetic mice,
19th International Vascular Biology Meeting, Boston, Nov. 2016. HMM Salim, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Glycemic control with canagliflozin, a SGLT2 inhibitor, inhibited inflammation in the vascular and adipose tissue, and ameliorated vascular complication in diabetic mice,
19th International Vascular Biology Meeting, Boston, Nov. 2016. Daiju Fukuda, S Nishimoto, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Cell free DNA/Toll-like receptor 9 axis plays a pivotal role in chronic inflammation induced by metabolic disorders, leading to atherogenesis and insulin resistance,
19th International Vascular Biology Meeting, Boston, Nov. 2016. Nishimoto Sachiko, Daiju Fukuda, Higashikuni Yasutomi, Tanaka Kimie, Hirata Yoichiro, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Michio Shimabukuro and Masataka Sata :
Genetic deletion of TLR9 promotes blood flow recovery in hind limb ischemia,
19th International Vascular Biology Meeting, Nov. 2016. Kenya Kusunose, Hirotsugu Yamada, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients with Tachycardia-induced Cardiomyopathy,
KSC2016(The 60th Annual Scientific Meeting of The Korean Society of Cardiology), Seoul, Sep. 2016. Takeshi Soeki, Tomomi Matsuura, E Uematsu, S Bando, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Increased local production of C-type natriuretic peptide in patients with vasospastic angina,
ESC Congress 2016, Rome, Aug. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, R Ueno, H Ito, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Paclitaxel eluting balloon angioplasty equals everolimus eluting stent implantation in local coagulative and inflammatory responses in stable angina patients,
ESC Congress 2016, Rome, Aug. 2016. T Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, T Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Oral Direct Factor Xa Inhibitor Prevents Atrial Fibrillation by Inhibiting Inflammation in Rapidly Paced Spontaneously Hypertensive Rats,
ESC Congress 2016, Rome, Aug. 2016. H Seno, Kenya Kusunose, Hirotsugu Yamada, Y Saijo, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain Between Vender-Dependent and Vender-Independent Two-Dimensional Speckle Tracking Software,
ACC Scientific Sessions 2016, Chicago, Apr. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Atrial Late Potentials and Atrial Substrate Remodeling in Patients With Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Apolipoprotein-e Deficient Mice Through GLP-1 Dependent and Independent Manners.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Y Hirata, Hirotsugu Yamada, Kenya Kusunose, S Nishio, Mika Bando, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Clinical Utility of Echocardiographic Epicardial Adipose Tissue Thickness Measured Using a High-frequency Linear Probe in Patients with Coronary Artery Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Takeshi Soeki, S Bando, Tomomi Matsuura, Takeshi Tobiume, E Uematsu, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combination Of Clinical, Electrocardiographic and Echocardiographic Parameters Predict the Onset of Atrial Fibrillation.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. S Nishimoto, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Michio Shimabukuro and Masataka Sata :
Toll-like Receptor 9 Plays a Pivotal Role in Angiotensin II-induced Atherosclerosis.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. Kenya Kusunose, Hirotsugu Yamada, Mika Bando, S Nishio, Y Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Pressure-flow Relationship of Pulmonary Circulation Determines Six-minute Walk Distance in Connective Tissue Disease.,
AHA Scientific Sessions 2015, Orlando, Nov. 2015. R Hashimoto, Michio Shimabukuro, HM Salim, T Hara, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Antagonism of protease-activated receptor 2 (PAR-2) rescues vascular endothelial dysfunction in diabetic mice.,
ESC Congress 2015, London, Aug. 2015. S Nishimoto, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Michio Shimabukuro and Masataka Sata :
The activation of toll-like receptor 9 deteriorates blood flow recovery after hind-limb ischemia.,
ESC Congress 2015, London, Aug. 2015. Koji Yamaguchi, Tetsuzo Wakatsuki, A Takashima, Mika Bando, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local coagulation after implantation of new generation drug-eluting stents compared with sirolimus-eluting stent.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. S Nishimoto, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Michio Shimabukuro and Masataka Sata :
Genetic deletion of toll-like receptor 9 accelerates blood flow recovery after hindlimb ischemia.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. T Hara, D Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation after mechanical vascular injury.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. H Yamazaki, Tetsuzo Wakatsuki, Koji Yamaguchi, K Imada, K Matsumoto, Y Takagawa, E Takagi, Y Saijo, T Hara, Y Saito, Mika Bando, A Takashima, S Bando, Tomomi Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of second-generation drug-eluting stent compared with first-generation drug-eluting stents.,
AHA Scientific Sessions 2014, Chicago, Nov. 2014. Michio Shimabukuro, Sachiko Matsumoto, Daiju Fukuda, T Hara, Takeshi Soeki and Masataka Sata :
Antagonism of protease-activated receptors salvages vascular endothelial dysfunction in KK-Ay diabetic mice: a novel mechanism of rivaroxaban, an oral factor Xa inhibitor.,
ESC 2014, Barcelona, Aug. 2014. Michio Shimabukuro, Masayoshi Ishida, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki and Masataka Sata :
Post-transcriptional regulation of adiponectin by microRNA-378 in adipose tissue: a novel mechanism for hypoadiponectinemia.,
ESC 2014, Barcelona, Aug. 2014. Tomomi Matsuura, Takeshi Soeki, E Uematsu, S Bando, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A renin inhibitor prevents atrial endocardial dysfunction in rapidly paced rats with streptozotocin-induced diabetes.,
ESC 2014, Barcelona, Aug. 2014. Takeshi Soeki, E Uematsu, S Bando, Tomomi Matsuura, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. S Bando, Takeshi Soeki, Takeshi Tobiume, Tomomi Matsuura, E Uematsu, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
ESC 2014, Barcelona, Aug. 2014. S Bando, Daiju Fukuda, Takeshi Soeki, E Uematsu, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 inflammasome activation in adipose tissue and atherosclerosis.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates neointima formation following vascular injury in the mouse through the inhibition of proliferative activation of vascular smooth muscle cells.,
ESC 2014, Barcelona, Aug. 2014. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, M Shimabukuro and Masataka Sata :
Rivaroxaban, a direct factor Xa inhibitor, attenuates plaque progression and destabilization in ApoE-deficient mice by inhibiting macrophage activation.,
ESC 2014, Barcelona, Aug. 2014. Junko Hotsuchi, Hirotsugu Yamada, Y Saijo, Mika Bando, S Hayashi, S Nishio, M Yamano, Y Torii, Y Hirata, R Amano, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Serial Changes of Exercise Stress Echocardiographic Parameters in Patients with Connective Tissue Disease without Overt Pulmonary Hypertension.,
ASE 2014, Portland, Jun. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, R Amano, Y Hirata, Junko Hotsuchi, Y Saijo, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Predicting Restenosis of Coronary Artery Stents by Ultrasound Tissue Characteristics of Carotid Artery Plaque.,
ASE 2014, Portland, Jun. 2014. Y Saijo, Hirotsugu Yamada, Junko Hotsuchi, S Nishio, S Hayashi, Mika Bando, Y Hirata, R Amano, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular systolic dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease.,
ACC 2014, Washington, D.C., Mar. 2014. Junko Hotsuchi, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Y Hirata, R Amano, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right ventricular dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease : an assessment using tricuspid annular motion velocities.,
Euro Echo Imaging 2013, Istanbul, Dec. 2013. S Hayashi, Hirotsugu Yamada, Junko Hotsuchi, Mika Bando, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Noninvasively Obtained Augmentation Index is Not a Reliable Maker for Vascular Sclerosis in Elderly Subjects.,
American Heart Association AHA 2013, Dallas, Nov. 2013. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban, A Novel Oral Anticoagulant, Attenuates Plaque Progression in ApoE-Deficient Mice Through the Inhibition of Pro-Inflammatory Activation of Macrophages.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Impact Of Indoxy1 Sulfate, A Uremic Toxin, On Non-culprit Coronary Plaque Composition Assessed By Integrated Backscatter Intravascular Ultrasound In Patients With Coronary Artery Disease.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Decreased Local Hypercoagulation after Implantation of Everolimus-Eluting and Zotarolimus-Eluting Stents Compared with Early-Generation Drug-Eluting Stents in patients with stable angina.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent Changes Of Local Vascular Response And Angiographic Peri-stent Contrast Staining Up To Five Years After Zotarolimus-eluting, Sirolimus-eluting, And Bare Metal Stent Implantation.,
American Heart Association AHA 2013, Dallas, Nov. 2013. S Nishimoto, Daiju Fukuda, Michio Shimabukuro, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Yutaka Nakaya and Masataka Sata :
Macrophage Toll-like Receptor 9 Signaling Contributes to the Development of Insulin Resistance through the Promotion of Inflammation in Adipose Tissue.,
American Heart Association AHA 2013, Dallas, Nov. 2013. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki, H Sato, E Uematsu, Hirofumi Izaki, Hiro-omi Kanayama and Masataka Sata :
Post-Transcriptional Regulation of Adiponectin by Micro-RNA 378 in Human Visceral and Subcutaneous Adipose Tissue.,
American Heart Association AHA 2013, Dallas, Nov. 2013. S Bando, Takeshi Soeki, T Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) level is elevated in patients with cancer.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Bando, Takeshi Soeki, E Uematsu, T Matsuura, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, S Bando, T Matsuura, E Uenmatsu, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Electrophysiological correlation and prognostic impact of pentraxin 3 as a local inflammatory marker in atrial fibrillation.,
ESC Congress 2013, Amsterdam, Aug. 2013. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure assessed by optical coherence tomography associated with local inflammatory response.,
ESC Congress 2013, Amsterdam, Aug. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of everolimus-eluting and zotarolimus-eluting stents compared with early-generation drug-eluting stents in patients with stable angina.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Nishimoto, Daiju Fukuda, Michio Shimabukuro, S Matsumoto, Masayoshi Ishida, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Yutaka Nakaya and Masataka Sata :
Genetic ablation of TLR9 improves insulin resistance through macrophage accumulation in adipose tissue.,
ESC Congress 2013, Amsterdam, Aug. 2013. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki, H Sato, E Uematsu, Hirofumi Izaki, Hiro-omi Kanayama and Masataka Sata :
MicroRNA-100 regulates a cluster of adipocytokine expression: A human biopsy study in subcutaneous and visceral adipose tissue.,
ESC Congress 2013, Amsterdam, Aug. 2013. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki, H Sato, E Uematsu, Hirofumi Izaki, Hiro-omi Kanayama and Masataka Sata :
MicroRNA miR-378 regulates adipocytokine fate by targeting transcriptional factors in human visceral and subctaneous adipose tissue.,
ESC Congress 2013, Amsterdam, Aug. 2013. Takeshi Soeki, K Yamaguchi, S Bando, T Matsuura, E Uematsu, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA plasma levels are associated with coronary plaque vulnerability.,
ESC Congress 2013, Amsterdam, Aug. 2013. Y Hirata, Hirotsugu Yamada, S Nishio, Mika Bando, S Hayashi, Junko Hotsuchi, T Tomofuji, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic epicardial adipose tissue thickness in anterior interventricular groove is a marker for the presence and severity of coronary artery disease.,
ESC Congress 2013, Amsterdam, Aug. 2013. S Hayashi, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, Mika Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Augmentation Index Measured by Tonometry Significantly Underestimates Atrial Stiffness in Ischemic Heart Disease in Japanese Population.,
第77回日本循環器学会学術集会, Yokohama, Mar. 2013. Mika Bando, Hirotsugu Yamada, Toshiyuki Niki, S Nishio, R Tamai, J Hotchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque.,
American College of Cardiology (ACC) 2013 Scientific Sessions, San Francisco, Mar. 2013. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, M Kadota, T Hara, S Bando, Toshiyuki Niki, J Hotchi, N Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oeduka, Mika Bando, K. Ogasawara, S. Bando, J. Hotchi, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, K. Ogasawara, S. Bando, T. Matsuura, J. Hotch, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems.,
AHA Scientific Sessions 2012, Nov. 2012. A. Takashima, Takayuki Ise, Masashi Akaike, Yuka Ueda, Takashi Iwase, T. Hara, M. Kadota, R. Ohta, K. Ogasawara, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac Rehabilitation Reduces Levels of Oxidized LDL.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Bando, Takeshi Soeki, E. Uematsu, T. Matsuura, M. Kadota, T. Hara, R. Ohta, Y. Kawabata, K. Ogasawara, Mika Bando, Toshiyuki Niki, Takayuki Ise, J. Hotchi, N. Tomita, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Kimura, Yuka Ueda, Takayuki Ise, Takashi Iwase, K. Maeda, K. Nishikawa, K. Ogasawara, Mika Bando, S. Bando, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, N. Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Takeshi Soeki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity.,
ESC Congress 2012, Munich, Aug. 2012. Takeshi Soeki, M. Kitani, Hirotsugu Yamada, Tetsuzo Wakatsuki, T. Kawano, S. Orino, K. Kawano, A. Kakutani, S. Bando and Masataka Sata :
Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients.,
ESC Congress 2012, Munich, Aug. 2012. M. Dagvasumberel, Michio Shimabukuro, Junji Ueno, T. Nishiuchi, Takeshi Soeki, Takashi Iwase, Shoichiro Takao, Hirotsugu Yamada, Tetsuya Kitagawa and Masataka Sata :
Gender disparities in the association of epicardial adipose tissue volume and coronary atherosclerosis: a 256-slice multidetector computed tomography study.,
ESC Congress 2012, Aug. 2012. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, S Bando, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS.,
ESC Congress 2012, Munich, Aug. 2012. Mika Bando, Hirotsugu Yamada, N Tomita, S. Nishio, R. Tamai, S. Hayashi, J. Hotchi, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Left Ventricular Geometry and Function in Patients with Sigmoid Septum.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. S Hayashi, Hirotsugu Yamada, N Tomita, J Hotchi, Mika Bando, S Nishio, R Tamai, M Nakagawa, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, N. Tomita, S. Hayashi, J. Hotchi, M. Nakagawa, D. Hirota, Y. Hirata, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Statin Therapy on Regression of Carotid Artery Plaque Assessed by High-Resolution Color Mapping Method Based on Integrated Backscatter.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, S Nishio, Kenya Kusunose, N Tomita, S Hayashi, Mika Bando, R Tamai, M Nakagawa, D Hirota, Y Hirata, K Ogasawara, S Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Efficacy of Six-minute Walk Stress Echocardiography for Detection of Pulmonary Arterial Hypertension in Patients With Connective Tissue Disease.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. J. Hotchi, Hirotsugu Yamada, R. Tamai, S. Nishio, N. Tomita, S. Hayashi, Mika Bando, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Assessment of Tricuspid Annular Motion Velocities in Pulmonary Hypertension of Various Etiologies.,
American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions, Maryland, Jun. 2012. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, J. Hotchi, R. Tamai, D. Hirota, Y. Hirata, Mika Bando, K. Ogasawara, A. Takashima, H. Yamazaki, S. Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Single-Beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, H. Yamazaki, A. Takashima, K. Ogasawara, Mika Bando, Takayuki Ise, H. Takeuchi, N. Tomita, Yuka Ueda, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Pentraxin 3 is a Local Inflammatory Maker in Atrial Fibrillation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Mika Bando, Hirotsugu Yamada, S. Nishio, E. Uematsu, S. Hayashi, J. Hotchi, Kenya Kusunose, N. Tomita, R. Tamai, Y. Hirata, D. Hirota, M. Nakagawa, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Ultrasonic Tissue Characterization of Carotid Artery Plaque using High-resolution Integrated Backscatter Imaging;Validation Study with Histological Correlation.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Takeshi Soeki, Toshiyuki Niki, Yoshio Taketani, H. Oezuka, S. Bando, N. Tomita, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada and Masataka Sata :
Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, N. Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. S. Nishio, Hirotsugu Yamada, R. Tamai, K. Endo, S. Hayashi, Kenya Kusunose, Takeshi Soeki, Tetsuzo Wakatsuki, Y. Sakai and Masataka Sata :
Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model: echocardiographic evaluation by 2D speckle tracking.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential response of local persistent hypercoagulability after zotarolimus-eluting, paclitaxel-eluting, sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, Kenya Kusunose, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Time-dependent changes of local coagulative response up to five years after sirolimus-eluting and bare-metal stent implantation in patients with stable angina.,
ESC Congress 2011, Paris, Aug. 2011. Takeshi Soeki, S. Bando, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Elevated concentration of pentraxin 3 is associated with local inflammation in atrial fibrillation.,
ESC Congress 2011, Paris, Aug. 2011. Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Kenya Kusunose, S. Bando, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Long-term local inflammatory and coagulative responses after coronary artery stenting with drug-eluting stent.,
ESC Congress 2011, Paris, Aug. 2011. R. Tamai, Hirotsugu Yamada, S. Nishio, Kenya Kusunose, N. Tomita, S. Hayashi, M. Sato, H. Hiraoka, J. Miki, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Tricuspid Annular Motion Velocities in Patients with Pulmonary Arteril Hypertension Secondary to Heart Failure.,
American Society of Echocardiography 2011. 22st Annual Scientific Sessions. Montreal, Montreal, Jun. 2011. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ストレインイメージング法を用いた心房細動例の左室心筋機能評価―左室圧曲線との同時記録による検討―,
第98回日本循環器学会中国・四国合同地方会, 徳島, 2011年5月. S Nishio, Hirotsugu Yamada, R Tamai, K Endo, S Hayashi, Kenya Kusunose, N Tomita, J Miki, S Bando, S Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Relationship Between Carotid Artery Stiffness Parameter β and Brachial Artery Flow-mediated Dilation in coronary Artery Disease.,
American College of Cardiology 2011, New Orleans, Apr. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, S. Hisaoka, Kenya Kusunose, Yuka Ueda, H. Takeuchi, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-dependent Changes Of Local Coagulative Response Up To Five Years After Sirolimus-eluting Stent Implantation.,
American Heart Association 2010, Chicago, Nov. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity Predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway.,
American Heart Association 2010, Chicago, Nov. 2010. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Impact of Statin Theraphy on Local Coagulative Response after sirolimus-eluting Stent Implantation in late chronic Phase.,
ESC CONGRESS 2010, Stockholm, Aug. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Preload on Left Ventricular Dyssynchrony in Patients with Dilated Cardiomyopathy: Assessment with Real-Time Three-Dimensional Echocardiography.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. H Takashima, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, C Mimura, K Endo, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Association of Carotid Artery Atherosclerosis with Aortic Valve Sclerosis.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, J Miki, N Tomita, H Takashima, C Mimura, M Yamanaka, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal / Restrictive Transmitral Flow Velocity Pattern Using its Response to Nitroglycerin Spray Oral Administration.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal Transmitral Flow Velocity Pattern using its Change by Nitroglycerin Spray Oral Administration.,
American College of Cardiology 2010, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Doppler Echocardiographic Estimation of Left Ventricular End-diastolic Pressure in Challenging,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Evaluation of Secondary Pulmonary Hypertension by Tricuspid Annular Velocity Profile Using Pulsed Tissue Doppler Imaging.,
第74回日本循環器学会総会・学術集会, Mar. 2010. N Tomita, Hirotsugu Yamada, Kenya Kusunose, S Nishio, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Patent Foramen Ovale by Contrast Realtime 3-dimensional Transesophageal Echocardiography.,
第74回日本循環器学会総会・学術集会, Mar. 2010. K Endo, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata :
N-3 Fatty Acids, IMT and CKD as Risk Factors in Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, K Endo, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Evaluation of Stiffness Parameter beta of Common Carotid Artery Obtained by Echo-tracking Method in Coronary Heart Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. T Niki, Takeshi Soeki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Utility of Cardiac Magnetic Resonance for Detection of Cardiac Involvement in Female Carriers of Duchenne Muscular Dystrophy.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takeshi Soeki, Kunihiko Koshiba, T Niki, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
Ghrelin Protects Heart against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Myocardial Amyloid Involvement Using 2-Dimentional Speckle Tracking Echocardiography: Utilization of Inner and Outer Myocardial Strain and Strain Rate.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-Dependent Changes of Local Coagulative Response up to Five Years after Sirolimus-Eluting Stent Implantation.,
第74回日本循環器学会総会・学術集会, Mar. 2010. C Mimura, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, H Takashima, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Predictive Value of Subepicardial Fat Thickness in Coronary Artery Sclerosis in Comparison with Intima-media Thickness,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Predictors of Local Persistent Hypercoagulability After Sirolimus-eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
American Heart Association 2009, Nov. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prognostic Value of Changes in Transmitral Flow Velocity Pattern During Leg Positive Pressure in Mild Heart Failure: A Clinical Application of "Preload Stress Echocardiography",
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting. Bare Metal vs Sirolimus-Eluting vs Paclitaxel-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Kunihiko Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, Y Hirata, Koji Yamaguchi, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
C-type Natriuretic Peptide Ameliorates the Progression of Experimental Autoimmune Myocarditis.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting -BMS vs SES vs PES-.,
ESC Congress 2009, Aug. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma concentration of pentraxin 3 is a useful marker for monitoring the anti-plaque effect of telmisartan.,
ESC Congress 2009, Aug. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after drug-eluting stent implantation: siroliumus-eluting stent vs. paclitaxel-eluting stent.,
ESC Congress 2009, Aug. 2009. Y Fukuda, Takeshi Soeki, N Fukuda, S Morishita, K Sakabe, H Shinohara, Y Tamura, Masashi Akaike, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takashi Iwase, Shusuke Yagi, Kunihiko Koshiba, Koji Yamaguchi, Kenya Kusunose, T Niki and Masataka Sata :
Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, S Yoshida, Y Sumitomo, Ken-ichi Aihara, Toshio Matsumoto and Masataka Sata :
Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Y Hirata, H Iwata, K Nakamura, Y Sakai, N Tomita, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shinji Nagahiro and Masataka Sata :
Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, H Satoh and Masataka Sata :
Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, N Tomita, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation: Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Sakamoto, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy - the Utility of Cardiac Magnetic Resonance.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, Kunihiko Koshiba, T Niki, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Ghrelin on Autonomic Activity in Healthy Volunteers.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical utility of B-Flowimaging on ultrasound examination of carotid artery.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response after Coronary Artery Stenting -BMS vs. SES vs. PES-,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
The Mitral L-wave Predicts Adverse Response to Volume Overloading in Patients with Atrial Fibrillation.,
58th American College of Cardiology, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Velocity Profile by Pulsed Tissue Doppler Imaging for the Assessment of Serial Change of Pulmonary Artery Pressure in Secondary Pulmonary Hypertension.,
58th American College of Cardiology, Mar. 2009. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
American Heart Association 2008, New Orleans, Nov. 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
American Heart Association 2008, New Orleans, Nov. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.,
ESC Congress 2008, Munich, Aug. 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
ESC Congress 2008, Munich, Aug. 2008. K Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, K Yamaguchi, Hirotsugu Yamada and Tetsuzo Wakatsuki :
C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.,
ESC Congress 2008, Munich, Aug. 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, K Takechi, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku, Y Maeda and Hirotsugu Yamada :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study),
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Effect of Preload Increment on Early Diastolic Transmitral and Mitral Annular Velocities in Patients with Old Myocardial Infarction.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-wave Predicts the Cardiac Response to an Increase of Preload in Atrial Fibrillation.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Measurement of Left Atrial Volume Curve by Advanced 2D Tissue Tracking Technique: Validation by Contrast Multidetector Computed Tomography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Hirotsugu Yamada, Kenya Kusunose, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki and Tetsuzo Wakatsuki :
Assessment of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation Using Dual Pulsed Doppler Echocardiography.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Seattle, Jun. 2007. Kenya Kusunose, Hirotsugu Yamada, T Niki, T Nakajima, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Relationship Between the Ratio of Peak Early diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.,
American College of Cardiology 56th Annual Scientific Session, New Orleans, Mar. 2007. K Koshiba, Takeshi Soeki, Y Fukuda, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin prevents cardiac remodeling after myocardial infarction via the suppression of cardiac sympathetic nerve activity.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Tetsuzo Wakatsuki, K Yamaguchi, Y Fukuda, K Koshiba, Tomohito Kawano, Takeshi Soeki and Hirotsugu Yamada :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Y Fukuda, Takeshi Soeki, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Significance and therapeutic potential of C-type natriuretic peptide in myocardial infarction.,
World Congress of Cardiology 2006, Barcelona, Sep. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Differentiation of Left Atrial Dysfunction by Changes in Transmitral Flow Velocities during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Myocardial Strain Evaluated by 2D Tissue Tracking during Lower Body Positive Pressure.,
17th Annual Scientific Sessions of the American Society of Echocardiography, Baltimore, Jun. 2006. Tomohito Kawano, Yamato Fukuda, Tomonori Watanabe, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tomotsugu Tabata and Masahiro Nomura :
Coronary Atherosclerotic Plaque Stabilization of HMG-CoA Reductase inhibitor, Atorvastatin, Evaluated by 16-slice Multidetector-row CT (MDCT),
The 70th general meeting of a Japanese circulatory organ disease society, Mar. 2006. Takeshi Soeki, Y Fukuda, K Koshiba, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, K Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.,
American College of Cardiology 55th Annual Scientific Session, Atlanta, Mar. 2006. Takeshi Soeki, I Kishimoto, H Hosoda, M Yoshida, T Tokudome, T Horio, D Schwenke and K Kangawa :
Ghrelin suppresses cardiac sympathetic activity and attenuates early left ventricular remodeling in rats with myocardial infarction.,
American Heart Association Scientific Session 2005, Dallas, Nov. 2005. Takeshi Soeki, Ichiro Kishimoto, Takeshi Tokudome, Takeshi Horio and Kenji Kangawa :
C-type natriuretic peptide, a novel antifibrotic agent, attenuates cardiac remodeling and improves left ventricular dysfunction in dilated cardiomyopathy,
American College of Cardiology 54th Annual Scientific Session, Orlando, Mar. 2005. Takeshi Soeki, Ichiro Kishimoto, Hiroyuki Okumura and Kenji Kangawa :
C-type natriuretic peptide prevents cardiac remodeling after myocardial infarction,
American Heart Association Scientific Session 2003, Orlando, Nov. 2003. Takeshi Soeki, Nobuo Fukuda, Hisanori Shinohara, Koichi Sakabe, Yukiko Onose, Yuki Sawada and Yoshiyuki Tamura :
Pulsed Doppler and tissue Doppler evaluation of transmitral flow and mitral annular motion velocities in patients with mitral annular calcification,
23th European Society of Cardiology Annual Congress, Stockholm, Sep. 2001. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Sakabe Koichi, Yukiko Onose, Yuki Sawada and Nobuo Fukuda :
Serum hepatocyte growth factor predicts subsequent ventricular remodeling following myocardial infarction,
23th European Society of Cardiology Annual Congress, Stockholm, Sep. 2001. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Koichi Sakabe and Yukiko Onose :
Circulating soluble Fas ligand predicts subsequent ventricular remodeling following myocardial infarction,
23th European Society of Cardiology Annual Congress, Stockholm, Sep. 2001. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Koichi Sakabe, Yukiko Onose, Yuki Sawada and Nobuo Fukuda :
Platelet plasminogen activator inhibitor-1 predict cardiac events in patients with coronary atherosclerotic lesions,
10th International Congress on Cardiovascular Pharmacotherapy, Kyoto, Mar. 2001. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Yuki Sawada and Nobuo Fukuda :
Plasma concentrations of fibrinolytic factors in the subacute phase of acute myocardial infarction predict recurrence of myocardial infarction,
American College of Cardiology 50th Annual Scientific Session, Orlando, Mar. 2001. R Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Tomonori Takahashi, H Orino, I Yagi, Tomoko Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions,
第88回日本循環器学会学術集会, Mar. 2024. Yutaka Kawabata, Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, Ryo Bando, Yoshihito Saijyo, 門田宗之, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Microvasculature and Gene Expression in Pericoronary Adipose Tissue According to Coronary Plaque Progression Stage in Fresh Cadavers,
第88回日本循環器学会学術集会, Mar. 2024. Yoshihito Saijyo, Hirotsugu Yamada, 長野絋平, 折野逸人, 八木一成, TAKAHASHI Tomoko, Zengu Robahto, BANDO Ryo, Tomonori Takahashi, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Incremental Value of Relative Apical Sparing Index for Discrimination of Cardiac Amyloidosis Subtypes,
第88回日本循環器学会学術集会, Mar. 2024. M Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
High Serum lipoprotein (a) level is a risk factor of poor prognosis after transcatheter aortic valve implantation,
第88回日本循環器学会学術集会, Mar. 2024. Ryo Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Tomonori Takahashi, Hayato Orino, Issei Yagi, Tomonori Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. 川端豊, 山口浩司, 若槻哲三, 髙橋智紀, 坂東遼, 西條良仁, 門田宗之, 松浦朋美, 伊勢孝之, 八木秀介, 添木武, 佐田政隆 :
Microvasculature and Gene Expression in Pericoronary Adipose Tissue According to Coronary Plaque Progression Stage in Fresh Cadavers,
第88回日本循環器学会学術集会, 2024年3月. M Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
High Serum lipoprotein (a) level is a risk factor of poor prognosis after transcatheter aortic valve implantation,
第88回日本循環器学会学術集会 JCS2024, Mar. 2024. 八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討,
第123回日本循環器学会四国支部地方会, 2023年12月. 八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討,
第123回日本循環器学会四国支部地方会, 2023年10月. 平田有紀奈, 山田博胤, 山口夏美, 森田沙瑛, 西尾進, 髙橋智紀, 西條良仁, 楠瀬賢也, 添木武, 佐田政隆 :
マラソンと左房機能:スポーツ後の Cardiac fatigue とは,
96回日本超音波医学会学術集会, 2023年5月. Zengu Robahto, Muneyuki Kadota, Keita Ohtani, Hayato Orino, Yusuke Negishi, Tomoko Takahashi, Ryo Bando, Hiromitsu Seno, Tomonori Takahashi, Yoshihito Saijyo, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
A Case of Biopsy-Proven Giant Cell Myocarditis,
第37回日本心エコー図学会学術集会, Apr. 2023. 山田博胤, 大櫛祐一郎, 楠瀬賢也, ゼングローバート, 髙橋智紀, 西條良仁, 西尾進, 平田有紀奈, 添木武, 佐田政隆 :
乳癌の薬物療法における心エコー図検査を用いた心毒性サーベイランスの有用性,
第37回日本心エコー図学会学術集会, 2023年4月. Akihiro Tani, Takeshi Soeki, 小崎裕司, Ken-ichi Aihara and Masataka Sata :
Concomitant Sarcopenia and Atrial Fibrillation is Associated with Heart Failure in Elderly Patients,
第87回日本循環器学会学術集会, Mar. 2023. BANDO Ryo, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, Tomonori Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels,
第87回日本循環器学会学術集会, Mar. 2023. Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, Tomonori Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients,
第87回日本循環器学会学術集会, Mar. 2023. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, BANDO Ryo, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Impact of Coronary Plaque Progression Stage on Coronary Neovascularization Structures in Fresh Cadavers,
第87回日本循環器学会学術集会, Mar. 2023. Takayuki Ise, Shusuke Yagi, Rie Ueno, Muneyuki Kadota, Keita Ohtani, Yusuke Negishi, Ryota Miyamoto, BANDO Ryo, Zengu Robahto, Hiromitsu Seno, Tomonori Takahashi, Yutaka Kawabata, Yoshihito Saijyo, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Novel Home-based Cardiac Telerehabilitation System Using a Wearable Device and a Web Application,
第87回日本循環器学会学術集会, Mar. 2023. S Yamaguchi, M Maeda, K Ohba, M Glinu, O Arasaki, Shusuke Yagi, Kenya Kusunose, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, H Masuzaki, Masataka Sata and Michio Shimabukuro :
Sex Differences in the Association between Epicardial Adipose Tissue Volume and Left Atrial Volume Index,
第87回日本循環器学会学術集会, Mar. 2023. 森建介, 河田沙紀, 金子遥祐, 谷彰浩, 辻誠士郎, 中村信元, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
高齢2型糖尿病患者におけるGNRIスコアと骨格筋異常病態の検討,
第266回徳島医学会学術集会, 2023年2月. 吉田知哉, 伊勢孝之, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 川端豊, 松浦朋美, 西條良仁, 門田宗之, 楠瀬賢也, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 飯間努, 山本浩史, 佐田政隆 :
劇症型心筋炎に対してECPELLA導入で救命しえた症例,
第121回日本循環器学会四国地方会, 2022年12月. 高橋智紀, 楠瀬賢也, Robert Zheng, 瀬野弘光, 西條良仁, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動患者におけるイソプロテレノール負荷経食堂心エコー図法の有用性,
第121回日本循環器学会四国地方, 2022年12月. 森建介, 河田沙紀, 金子遥祐, 谷彰浩, 辻誠士郎, 中村信元, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
2型糖尿病患者の骨格筋異常におけるGNRIスコアの意義,
日本糖尿病学会中国四国地方会第60回総会, 2022年11月. 吉田知哉, 若槻哲三, 山木浩二, 西條良仁, 川端豊, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
冠動脈入口部および鎖骨下動脈に特徴的な血管内超音波所見を認めた高安動脈炎の2例,
第70回日本心臓病学会学術集会, 2022年9月. 大櫛祐一郎, 楠瀬賢也, 瀬野弘光, 高橋智紀, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるサーベイランスのがん治療関連心筋障害への影響,
第5回日本腫瘍循環器学会学術集会, 2022年9月. 松崎慶仁, 西條良仁, 伊勢孝之, 太田啓太, 折野逸人, 吉田知哉, 根岸佑典, 宮本亮太, 坂東遼, Rovert Zheng, 瀬野弘光, 高橋智紀, 上野理絵, 門田宗之, 原知也, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性A型大動脈解離をきたしたMarfan症候群の一例,
第265回徳島県医学学術集会, 2022年7月. 根岸佑典, 門田宗之, 山口浩司, 山田博胤, 折野逸人, 太田啓太, 吉田知哉, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 西條良仁, 上野理絵, 原知也, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 八木秀介, 添木武, 若槻哲三, 田蒔昌憲, 佐田政隆 :
腎動脈拡張術により心不全の著名な改善を認めたCardiac Disturbance syndrome の1例,
第265回徳島県医学学術集会, 2022年7月. 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 原知也, 上野理絵, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
パンデミック下の臨床実習におけるオンライン医学教育の実際と問題点,
第265回徳島県医学学術集会, 2022年6月. 林昌晃, 添木武, 玉上大暉, 野田康裕, 森西啓介, 近田優介, 松本和久, 松浦朋美, 大西芳明, 佐田政隆 :
心房細動アズレーション時の鎮静不安定化に寄与する因子の検討,
第68回日本不整脈心電学会学術大会, 2022年6月. 高橋里加子, 門田宗之, 伊勢孝之, 西條良仁, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
免疫抑制療法の導入により心機能が劇的に改善した巨細胞性心筋炎の一例,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 門田宗之, 楠瀬賢也, 八木秀介, 川端豊, 西條良仁, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全におけるサクビトリル / バルサルタンのナトリウム利尿ペプチドに対する急性反応の検討,
第120回日本循環器学会中国・四国合同地方会, 2022年5月. 山上紘規, 細木美苗, 堀太貴, 安井沙耶, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
Skin Autofluorescenceの糖尿病性腎臓病における臨床的意義の解析,
第65回日本糖尿病学会年次学術集会, 2022年5月. ツェレンソノムムンフツェツェゲ, 八木秀介, 伊勢孝之, 福田大受, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第9回日本心血管脳卒中学会学術集会, 2022年4月. 添木武, 福田大受, 佐田政隆 :
動脈効果の炎症性バイオマーカーの探求,
第7回日本血管不全学会, 2022年4月. Y Okushi, Kenya Kusunose, Zheng Robert, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Findings from the JROAD-DPC Registry across 6 Studies Conducted in a Year,
第86回日本循環器学術集会, Mar. 2022. Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, 伊勢孝之, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
First Assessment of Coronary Plaque Vulnerability and Lipid Core Burden Assessed by Near-Infrared Spectroscopy-Intravascular Ultrasound in a Fresh Cadaver,
第86回日本循環器学会学術集会, Mar. 2022. Tomonori Takahasi, Kenya Kusunose, Yukina Hirata, Susumu Nisio, Yuichiro Okushi, Hiromitsu Seno, Y Saijo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiovascular Risk Factors Associated with Left Ventricular Strain Distribution in Patients without Known Cardiovascular Disease,
第86回日本循環器学会学術集会, Mar. 2022. 西條良仁, 佐村高明, 高橋智子, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 秦広樹, 佐田政隆 :
滲出性収縮性心膜炎の1例,
第119回日本循環器学会四国地方会, 2021年12月. 數藤久美子, 福田大受, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マクロファージ特異的DNaseII欠損が動脈硬化に与える影響,
第119回日本循環器学会四国地方会, 2021年12月. 大櫛祐一郎, 楠瀬賢也, 西條良仁, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査によるがん治療関連心筋障害サーベイランスの有効性,
第119回日本循環器学会四国地方会, 2021年12月. 川端豊, 若槻哲三, 山口浩司, 門田宗之, 伊勢孝之, 楠瀬賢也, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
冠動脈塞栓症を発症した2症例の臨床的検討,
第69回日本心臓病学会学術集会, 2021年9月. 吉田知哉, 瀬野弘光, 松本和久, 松浦朋美, 西條良仁, 門田宗之, 川端豊, 楠瀬賢也, 伊勢孝之, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 多田恵曜, 佐田政隆 :
ペースメーカー植え込み後に発覚した側頭葉てんかんによる発作性心静止の一例,
第263回徳島医学会学術集会, 2021年8月. Tserensonom Munkhtsetseg, 八木秀介, 伊勢孝之, 門田宗之, 川端豊, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連,
第263回徳島医学会学術集会, 2021年8月. 手束一貴, 高橋智紀, 西條良仁, 川端豊, 門田宗之, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 秦広樹, 佐田政隆 :
ポスタ-セッション左冠動脈主幹部の急性冠症候群の2症例,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 伊勢孝之, 門田宗之, 川端豊, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐村高明, 藤本鋭貴, 秦広樹, 佐田政隆 :
合同シンポジウムカテ-テル大動脈弁置換術(TAVI)によって激変した大動脈弁狭窄症治療,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 添木武, 福田大受, 松浦朋美, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
Toll-Like Receptor 9 Is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
JHRS2021 第67回日本不整脈心電学会学術大会, 2021年7月. Tomomi Matsuura, Takeshi Soeki, Kazuhisa Matsumoto, Takeshi Tobiume and Masataka Sata :
Efficacy and Clinical Significance of Additional Left Atrial Posterior Wall Isolation in Patients with Persistent Atrial Fibrillation,
第67回日本不整脈心電学会学術大会, Jul. 2021. 瀬野弘光, 山口浩司, 楠瀬賢也, 山田博胤, 若槻哲三, 添木武, 佐田政隆, 佐村高明, 秦広樹, 大豆本圭 :
広範な心嚢腔内進展を認めた心臓腫瘍の一例,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 大櫛祐一郎, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ループ利尿薬使用下における心保護薬併用療法の有用性,
第116回第118回日本循環器学会中国・四国合同地方会, 2021年6月. 金子遥祐, 安井沙耶, 山上紘規, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
糖尿病患者における歩行速度規定臨床因子の解析,
第64回日本糖尿病学会年次学術集会, 2021年5月. 粟飯原賢一, 堀太貴, 山上紘規, 安井沙耶, 金子遥祐, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 安倍正博 :
生体電気インピーダンス法による細胞外水分比および位相角と糖尿病患者における血中HbおよびHtレベルの連関解析,
第64回日本糖尿病学会年次学術集会, 2021年5月. 西尾進, 山田博胤, 楠瀬賢也, 阿部美保, 林修司, 平田有紀奈, 山尾雅美, 添木武, 佐田政隆 :
徳島大学病院超音波センターの教育プログラム,
2021年5月. 山上紘規, 安井沙耶, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
糖尿病患者におけるDehydroepiandrosterone sulfate (DHEAS)の糖尿病性腎臓病進展および高血圧症罹患における意義,
第64回日本糖尿病学会年次学術集会, 2021年5月. 楠瀬賢也, 荒瀬美晴, 平田有紀奈, 西尾進, 山尾雅美, 山田博胤, 阿部美保, 添木武, 佐田政隆 :
強皮症における6分間歩行負荷により評価した左室拡張能の臨床的意義,
第94回日本超音波医学会学術集会, 2021年5月. 安井沙耶, 山上紘規, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
糖尿病患者における非アルコール性脂肪肝疾患および骨格筋異常症におけるDehydroepiandrosterone sulfate (DHEAS)の意義,
第64回日本糖尿病学会年次学術集会, 2021年5月. 瀬野弘光, 松本和久, 松浦朋美, 飛梅威, 添木武, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込み後にj発覚した側頭葉てんかんによる発作性心静止の1例,
第124回日本内科学会四国地方会, 2021年5月. 金子遥祐, 湯浅智之, 添木武, 乙田敏城, 谷口達哉, 粟飯原賢一, 安井沙耶, 堀太貴, 山上紘規, 中村信元 :
糖尿病患者における歩行速度規定臨床因子の解析,
糖尿病, Vol.64, No.Suppl.1, III-133-4, 2021年5月. 山上紘規, 安井沙耶, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
糖尿病患者におけるDehydroepiandrosterone sulfate(DHEAS)の糖尿病性腎臓病進展および高血圧症罹患における意義,
糖尿病, Vol.64, No.Suppl.1, P-35-6, 2021年5月. 堀太貴, 山上紘規, 安井沙耶, 金子遥祐, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 安倍正博, 粟飯原賢一 :
生体電気インピーダンス法による細胞外水分比および位相角は糖尿病患者の血中HbおよびHtレベルを規定する,
第94回日本内分泌学会学術総会, 2021年4月. 山上紘規, 安井沙耶, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
Dehydroepiandrosterone sulfate (DHEAS)高値は糖尿病性腎臓病進展および高血圧症罹患のリスクとなる,
第94回日本内分泌学会学術総会, 2021年4月. 金子遥祐, 安井沙耶, 山上紘規, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
生活習慣病患者の歩行速度は骨格筋量よりも筋力が規定する,
第94回日本内分泌学会学術総会, 2021年4月. 金子遥祐, 安井沙耶, 山上紘規, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
生活習慣病患者の歩行速度は骨格筋量よりも筋力が規定する,
日本内分泌学会雑誌, Vol.97, No.1, 366, 2021年4月.

(キーワード): *筋骨格系生理学的現象 *骨格筋 *身体組成 *筋力 *生活習慣病(診断) *歩行速度 *筋量ヒト男女

山上紘規, 金子遥祐, 安井沙耶, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
Dehydroepiandrosterone sulfate(DHEAS)高値は糖尿病性腎臓病進展および高血圧症罹患のリスクとなる,
日本内分泌学会雑誌, Vol.97, No.1, 340, 2021年4月.

(キーワード): *高血圧(病因,診断) *糖尿病性腎症(病因,診断) *Dehydroepiandrosterone Sulfate(血液) ヒト男女

安井沙耶, 山上紘規, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
Dehydroepiandrosterone sulfate(DHEAS)は生活習慣病患者における非アルコール性脂肪肝疾患およびダイナペニアの発症抑制因子である,
日本内分泌学会雑誌, Vol.97, No.1, 287, 2021年4月.

(キーワード): *Dehydroepiandrosterone Sulfate(血液) *生活習慣病(診断,病因,合併症) *肝疾患-非アルコール性脂肪性(診断,病因,合併症) ヒト男女

PP Tran, Daiju Fukuda, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
DNA Damage Caused by Diabetes Induced Vascular Dysfunction : The Role of The Stimulator of Interferon Genes,
第85回日本循環器学会学術集会, Mar. 2021. PP Tran, Daiju Fukuda, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Stimulator of Interferon Genes Plays a Pivotal Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-deficient Mice,
第85回日本循環器学会学術集会, Mar. 2021. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Suto, 松本和久, Tomonori Takahashi, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Early and Chronic Phased Local Coagulative Responses Following Bioresorbable-polymer Drug-eluting Stent Implantation,
第85回日本循環器学会学術集会, Mar. 2021. 阿部美保, Kenya Kusunose, Y Okushi, Zheng Robert, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Vitamin D Supplementation on Heart Failure Mortality from Japanese Registry of All Cardiac and Vascular Datasets,
第85回日本循環器学会学術集会, Mar. 2021. 川端豊, 若槻哲三, 山口浩司, 福田大受, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 -未固定遺体における検討-,
Beyond Angiography Japan XXV, 2021年3月. 山田拓哉, 谷彰浩, 門田宗之, 伊勢孝之, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈四尖弁に対してTAVIを施行した一症例,
第262回徳島医師学会学術集会, 2021年3月. ムギー (名), 八木秀介, 門田宗之, 川端豊, 松本和久, 楠瀬賢也, 山口浩司, 飛梅威, 松浦朋美, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
当院におけるイバブラジンの使用経験,
第262回徳島医師学会学術集会, 2021年3月. 平田有紀奈, 楠瀬賢也, 辻拓将, 藤森康平, 山口夏美, 森田沙瑛, 西尾進, 大櫛祐一郎, 瀬野弘光, 高橋智紀, 伊勢孝之, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 古徳純一, 佐田政隆 :
ディープラーニングによる胸部X-pを用いた肺動脈圧上昇の検出,
第85回日本循環器学会学術集会, 2021年3月. Muneyuki Kadota, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hormonal Effect of the Angiotensin Receptor-Neprilysin Inhibitor in Patients with Chronic Heart Failure,
第85回日本循環器学会学術集会, Mar. 2021. 安井沙耶, 山上紘規, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
当院生活習慣病患者における骨格筋量に影響を与える因子の検討,
日本内分泌学会雑誌, Vol.96, No.3, 822, 2021年1月.

(キーワード): 筋骨格系生理学的現象 / 骨格筋 / 身体組成 / 生活習慣病(診断) / 筋量 / ヒト / 中年(45~64) / 高齢者(65~79) / 男 / 女

山上紘規, 安井沙耶, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
当院生活習慣病患者における握力と歩行速度に影響を与える因子の検討,
日本内分泌学会雑誌, Vol.96, No.3, 822, 2021年1月.

(キーワード): 加齢 / 握力 / 生活習慣病(診断) / 歩行速度 / 中年(45~64) / 高齢者(65~79) / 男 / 女

山上紘規, 安井沙耶, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
当院生活習慣病患者における握力と歩行速度に影響を与える因子の検討,
第20回日本内分泌学会四国支部学術集会, 2020年9月. 安井沙耶, 山上紘規, 金子遥祐, 堀太貴, 中村信元, 谷口達哉, 乙田敏城, 湯浅智之, 添木武, 粟飯原賢一 :
当院生活習慣病患者における骨格筋量に影響を与える因子の検討,
第20回日本内分泌学会四国支部学術集会, 2020年9月. Koji Yamaguchi, Tetsuzo Wakatsuki, Yuichiroh Ohkushi, Kumiko Sutou, Kazuhisa Matsumoto, Tomonori Takahashi, Muneyuki Kadota, 上野理絵, Yutaka Kawabata, Tomomi Matsura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Effect of Lower Strut Thickness and Faster Polymer Resorption on Chronic Local Coagulative Response after Drug Eluting Stent Implantation,
第84回日本循環器学会学術集会, Jul. 2020. Gulinu Maimaituxun, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Hirata Yukina, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata and Michio Shimabukuro :
Impact of Epicardial Adipose Tissue on Global Longitudinal Strain in Patients with Normal Left Ventricular Ejection Fraction,
第84回日本循環器学会学術集会, Jul. 2020. Ganbaatar Byambasuren, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
S1P2 Receptor Antagonist Attenuates Endothelial Dysfunction and Prevents Atherogenesis in Apolipoprotein-E-deficient Mice,
第84回日本循環器学会学術集会, Jul. 2020. Suto Kumiko, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Pemafibrate, a Novel Selective Peroxisome Proliferator-activated Receptor-α Modulator, Attenuates Vascular Inflammation and Endothelial Dysfunction in Diabetic Mice,
第84回日本循環器学会学術集会, Jul. 2020. 松本和久, 飛梅威, 松浦朋美, 添木武, 佐田政隆 :
断端処理後リードの先端露出に対して鎖骨骨膜固定法が有用であった1例,
第12回植込みデバイス関連冬季大会, 2020年2月. 髙橋智子, 松本和久, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
S-ICDにpolytetrafluoroethyleneを被覆したこと，肥満により胸骨リードの挿入が浅くなったことでshock impedanceが著名に上昇した1例,
第12回植込みデバイス関連冬季大会, 2020年2月. 本間友佳子, 早渕康信, 中野睦基, 香美祥二, 飛梅威, 添木武, 佐田政隆, 佐々木亜由美, 木下ゆき子, 森一博, 中島博 :
Bystander CPR からの救命の連鎖が奏効したQT延長症候群の1幼児例,
第153回日本小児科学会徳島地方会, 2019年12月. 松本和久, 川端豊, 松浦朋美, 飛梅威, 添木武, 山田博胤 :
リードレスペースメーカーの再挿入を要したアミロイドーシスの一例,
第115回日本循環器学会四国地方会, 2019年12月. 門田宗之, 楠瀬賢也, 伊勢孝之, 髙橋智紀, 藤本裕太, 大櫛祐一郎, 數藤久美子, 松本和久, 上野理絵, 川端豊, 山田なお, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ドブダミン負荷下での血行動態評価を行った潜在性閉塞性肥大型心筋症2症例の検討,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
クライオバルーンアブレーション後の肺静脈狭窄に対するDrug coated balloonの使用経験,
第115回日本循環器学会四国地方会, 2019年12月. 山口浩司, 若槻哲三, 松本和久, 髙橋智紀, 上野理絵, 川端豊, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
新規病変に対するDrug coated balloonの効果―局所血管反応と臨床成績について―,
第115回日本循環器学会四国地方会, 2019年12月. 飛梅威, 松浦朋美, 松本和久, 坂東左知子, 大河啓介, 添木武, 佐田政隆 :
房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1 例,
カテーテルアブレーション関連秋季大会2019, 2019年11月. 林昌晃, 添木武, 玉上大暉, 野田康裕, 森西啓介, 松本和久, 坂東左知子, 松浦朋美, 飛梅威, 大西芳明, 佐田政隆 :
心房細動アブレーション時の鎮静不安定化に影響を及ぼす背景因子の検討,
カテーテルアブレーション関連秋季大会2019, 2019年11月. 髙橋智子, 松浦朋美, 松本和久, 坂東左知子, 飛梅威, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
クライオバルーンアブレーション後にきたした高度肺静脈狭窄に対してDrugcoated balloon を用いて治療を行った1 例,
カテーテルアブレーション関連秋季大会2019, 2019年11月. 松本和久, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 佐田政隆 :
Crista terminalis を横断する伝導によりpseudo conduction を呈し，同部位への通電でcomplete isthmus block を確認し得た心房粗動の1 例,
カテーテルアブレーション関連秋季大会2019, 2019年11月. Ganbaatar Byambasuren, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
S1P2 antagonist attenuates endothelial dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient Mice,
日本性機能学会第30回学術集会, Sep. 2019. Pham Tran Phuong, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Rivaroxaban,a direct inhibitor of FXa,attenuated diabetes-induced endothelial dysfunction in wild-type mice,
日本性機能学会第30回学術集会, Sep. 2019. Arief Rahadian, Daiju Fukuda, Hotima Salim, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
SGLT2 inhibitor,Canagliflozin,Ameliorate Endothelial Dysfunction and Atherosclerosis in Diabetic ApoE-/- Mice,
日本性機能学会第30回学術集会, Sep. 2019. Aini Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin,a DPP-4 Inhibitor,prevents endothelial dysfunction in nondiabetic apolipoprotein E-deficient mice,
日本性機能学会第30回学術集会, Sep. 2019. 山口浩司, 若槻哲三, 川端豊, 山田なお, 楠瀬賢也, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Optical coherence omographyにより器質化血栓の存在が疑われた肺癌術後急性冠症候群の1例,
第67回日本心臓病学会学術集会, 2019年9月. 木田貴弘, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの進行に伴い明らかになり，恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の1例,
第259回徳島医学会学術集会, 2019年8月. 井口裕貴, 飛梅威, 松本和久, 坂東左知子, 松浦朋美, 添木武, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, 坂東美佳, 山田なお, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 佐田政隆 :
房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1例,
第259回徳島医学会学術集会, 2019年8月. Kazuhisa Matsumoto, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume and Masataka Sata :
Vidagliptin reduces inducibility of atrial fibrillation in hypertensive rats complicated with diabetes mellitus,
第66回日本不整脈心電学会学術大会, Jul. 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, Takashi Iwase, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Gender specific impact of epicardial adipose tissue thickness on coronary artery disease,
第19回日本抗加齢医学会総会, Jun. 2019. 添木武, 福田大受, 松浦朋美, 植松悦子, 佐田政隆 :
抗凝固薬の新しい可能性,
第4回J-ISCP(国際心血管薬物療法学会日本部会)年次学術集会会長企画セッション―心血管薬物治療の新たな可能性―, 2019年6月. 森田沙瑛, 西尾進, 楠瀬賢也, 添木武, 松本和久, 山口夏美, 平田有紀奈, 鳥居裕太, 西條良仁, 山田博胤, 佐田政隆 :
右室容量負荷の原因を経胸壁心エコー図検査で診断し得なかった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 數藤久美子, 楠瀬賢也, 松浦朋美, 山田なお, 松本和久, 上野理絵, 川端豊, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
進行性心不全を呈す抗ミトコンドリア抗体陽性筋炎の症例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 谷彰浩, 楠瀬賢也, 松本和久, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張期僧帽弁逆流の治療適応判断に心房心室同時ペーシングが有効であった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 志村拓哉, 伊勢孝之, 川端豊, 藤本裕太, 松本和久, 上野理絵, 山田なお, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 佐田政隆 :
先天性二尖弁に対するTAVIの2例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 大池由夏, 飛梅威, 松本和久, 山田なお, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 若槻哲三, 添木武, 山田博胤, 佐田政隆 :
His束より上方レベルの心房刺激でのみ誘発可能であった房室結節リエントリー性頻拍の1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 松本和久, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
心臓電気生理検査中に4種類の頻拍が出現し治療に難渋した一例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 中村昌史, 川端豊, 伊勢孝之, 藤本裕太, 原田貴文, 松本和久, 西條良仁, 上野理絵, 山田なお, 伊藤浩敬, 轟貴史, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 坂東左知子, 坂元裕一郎, 添木武, 山口遼, 吉本大祐, 鈴木孝彦, 中川博, 佐田政隆 :
心房細動アブレーション後の心房性不整脈検出における，14日間リードレスパッチ・ホルター心電図の有用性,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 西尾進, 楠瀬賢也, 平田有紀奈, 西條良仁, 山田なお, 鳥居裕太, 山尾雅美, 添木武, 山田博胤, 佐田政隆 :
右心機能評価,
日本超音波医学会第92回学術集会パネルディスカッション循環器2, 2019年5月. 山田博胤, 楠瀬賢也, 西條良仁, 山田なお, 鳥居裕太, 平田有紀奈, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
ASE/EACVI の心腔計測ガイドライン2015 の概要,
日本超音波医学会第92回学術集会パネルディスカッション循環器1, 2019年5月. 山田博胤, 西條良仁, 楠瀬賢也, 山田なお, 鳥居裕太, 平田有紀奈, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
「がん治療関連心筋障害(CTRCD)」の診療における心エコー図検査の有用性,
日本超音波医学会第92回学術集会シンポジウム循環器7, 2019年5月. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Tsukasa Iwase, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Michio Shimabukuro :
Type 2 diabetes but not apicardial adipose tissue thickness is a predictor for coronary artery diseases in women,
第62回日本糖尿病学会年次学術集会, May 2019. Gulinu Maimaituxun, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, Takeshi Soeki, Masataka Sata and Michio Shimabukuro :
Impact of epicardial adipose tissue thickness on left ventricular diastolic dysfunction in human,
第92回日本内分泌学会学術総会, May 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Kidney fat and its impact on coronary artery disease,
第4回日本血管不全学会学術集会・総会, Apr. 2019. Gulinu Maimaituxun, Daiju Fukuda, Shusuke Yagi, Yukina Hirata, T Iwase, S Takao, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masafumi Harada, Masataka Sata and Michio Shimabukuro :
Peri-renal fat volume is negatively associated with the adiponectin expression in human,
第4回日本血管不全学会学術集会・総会, Apr. 2019. Pham Tran Phuong, 福田大受, 八木秀介, 楠瀬賢也, 山田博胤, 添木武, 島袋充生, 佐田政隆 :
Rivaroxaban, A Direct Inhibitor of FXa, Attenuated Diabetes-induced Endothelial Dysfunction by Inhibiting FXa-protease Activated Receptor 2 Signaling,
第83回日本循環器学会学術集会, 2019年3月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Microluminal structures of coronary plaque and vasa vasorums affect coronary inflammation: A fresh cadaveric studys,
第83回日本循環器学会学術集会, 2019年3月. 添木武, 松浦朋美, 福田大受, 松本和久, 飛梅威, 楠瀬賢也, 山田博胤, 若槻哲三, 佐田政隆 :
The Factor Xa Inhibitor, Edoxaban, Prevents Cardiac Remodeling in Rats with Myocardial Infarction,
第83回日本循環器学会学術集会, 2019年3月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Coronary intraplaque microluminal structure are associated with the quality and quantity of epicardial adipose tissue -A fresh cadaveric stury-,
第83回日本循環器学会学術集会, 2019年3月. 平田有紀奈, 楠瀬賢也, 山田博胤, 森田沙瑛, 鳥居裕太, 西尾進, ゼングロバート, 西條良仁, 八木秀介, 添木武, 佐田政隆 :
マラソン完走後の左房リザーバーストレイン反応を予測する指標の検討,
第83回日本循環器学会学術集会, 2019年3月. Arief Rahadian, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Canagliflozin, a Sglt-2 Inhibitor, Prevents Endothelial Dysfunction and Atherosclerosis in Diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. Byambasuren Ganbaatar, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Empagliflozin Attenuates Endothelial Dysfunction and Atherogenesis by Inhibiting Inflammation in the Vasculature and Adipose Tissue in Diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. Aini Kunduziayi, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Vildagliptin, a DPP-4 Inhibitor, Prevents Atherogenesis Targeting Multiple Cell-types in Non-diabetic Apolipoprotein E-deficient Mice,
第83回日本循環器学会学術集会, Mar. 2019. 平田有紀奈, 楠瀬賢也, 山田博胤, 森田沙瑛, 鳥居裕太, 西尾進, 山口夏美, Robert Zheng, 西條良仁, 八木秀介, 添木武, 佐田政隆 :
カーフスリーブは下腿浮腫を軽減するか:表在エコー検査による検討,
第83回日本循環器学会学術集会, 2019年3月. 藤本裕太, 楠瀬賢也, 西條良仁, Robert Zheng, 原田貴文, 松本和久, 上野理絵, 川端豊, 山田なお, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 佐田政隆 :
Staphylococcus による感染性内膜炎の一例,
第113回日本循環器学会四国合同地方会, 2018年12月. Robert Zheng, 伊勢孝之, 川端豊, 八木秀介, 西條良仁, 上野理絵, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
Single coronary 合併重症ASに対してTAVIを施行し救命し得た1例,
第113回日本循環器学会四国合同地方会, 2018年12月. 山田博胤, 平田有紀奈, 坂東美佳, 楠瀬賢也, 西條良仁, 西尾進, 添木武, 佐田政隆 :
心外膜下脂肪厚の超音波計測とその臨床的意義,
第45回日本超音波医学会関西地方会, 2018年10月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体において光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連,
第66回日本心臓病学会学術集会, 2018年9月. Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Susumu Nishio, Hrada Osamu, Miyasato Naomi, Hrakuni Atsusi, Ito Nobuhiko, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Echocardiographic Evaluation of Epicardial Adipose Tissue Thickness in Patients with Coronary Artery Disease: A Multicenter Study,
第66回日本心臓病学会学術集会, Sep. 2018. 山口浩司, 若槻哲三, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
第三世代薬剤溶出性ステント留置後における局所凝固反応塗装ステント長の関連性,
第66回日本心臓病学会学術集会, 2018年9月. 平田有紀奈, 楠瀬賢也, 山田博胤, 鳥居裕太, 西尾進, 西條良仁, 坂東美佳, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
過度に蓄積した心外膜下脂肪は薬剤溶出型ステント留置後の再狭窄を予測するマーカーとなる,
第66回日本心臓病学会学術集会, 2018年9月. 福田大受, 山口浩司, 楠瀬賢也, 八木秀介, 山田博胤, 若槻哲三, 添木武, 佐田政隆 :
活性型血液凝固第X因子が冠動脈硬化に与える影響,
第66回日本心臓病学会学術集会, 2018年9月. 伊藤浩敬, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
AVNRTアブレーション治療後に発生したJunctional Tachycardiaの1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 轟貴史, 若槻哲三, 山口浩司, 瀬野弘光, 數藤久美子, 西條良仁, 川端豊, 上野理絵, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 福田大受, 山田博胤, 添木武, 佐田政隆 :
EES留置3年後，術前に抗血小板剤中止しペパリン置換したにもかかわらず2枝同時ステント閉塞を起こした1例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 清水郁子, 瀬野弘光, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 岩瀬俊, 黒部裕嗣, 北川哲也, 佐田政隆 :
一年の経過で急速に進行したCalcified Amorphous Tumor(CAT)に対し腫瘍摘出手術を行った一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. Robert Zheng, 數藤久美子, 楠瀬賢也, 松浦朋美, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 坂東美佳, 伊藤浩敬, 轟貴史, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
薬物治療が著効したSLE関連心筋炎の一例,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 西條良仁, 楠瀬賢也, 山田博胤, 西尾進, 瀬野弘光, 數藤久美子, 川端豊, 上野理絵, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
アトラサイクリン系抗癌剤による心筋障害の局在性および化学療法関連心筋障害との関連の検討,
第112回日本循環器学会中国・四国合同地方会, 2018年6月. 西條良仁, 山田博胤, 楠瀬賢也, 坂東美佳, 瀬野弘光, 西尾進, 鳥居裕太, 平田有紀奈, 天野理江, 山尾雅美, 添木武, 佐田政隆 :
化学療法関連心機能障害(CTRCD)に対し内科的加療が奏功した乳癌患者の一例,
日本心エコー図学会第29回学術集会, 2018年4月. Kenya Kusunose, Yoshihito Saijoh, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Right Ventricular Function Predicts Beneficial Effects of Cardiac Rehabilitation in Patients with Chronic Heart Failure,
第82回日本循環器学会, Mar. 2018. Yoshihito Saijoh, Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yuta Torii, Kumiko Sutou, 上野理絵, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Anthracyclines induce early changes in localized left ventricular dysfunction.,
第82回日本循環器学会, Mar. 2018. Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Takeshi Tobiume, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
C-type natriuretic peptide improves left ventricular diastolic dysfunction in HFpEF model rats.,
第82回日本循環器学会, Mar. 2018. BYAMBASUREN GANBAATAR, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Ticagrelor, a P2Y12 Antagonist,Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein-E-deficient Mice.,
第82回日本循環器学会, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Yoshihito Saijoh, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin -renin Feedback in Hypertensive Patients,
第82回日本循環器学会, Mar. 2018. Takayuki Ise, Shusuke Yagi, Yutaka Kawabata, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Rie Ueno, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effect of Handgrip Stress in Patients with Chronic Heart Failure.,
第82回日本循環器学会, Mar. 2018. Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Inhibition of Thrombin Signaling by Dabigatran, a Direct Thrombin Inhibitor,Attenuates Endothelial Dysfunction in Diabetic Mice.,
第82回日本循環器学会, Mar. 2018. Yukina Hirata, Kenya Kusunose, Hirotsugu Yamada, Yuta Torii, Susumu Nishio, Hiromitsu Seno, Tomomi Matsuura, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Marathon Running on Left Atrial function in healthy trained volunteers,
第82回日本循環器学会, Mar. 2018. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Itou, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel.,
第82回日本循環器学会, Mar. 2018. Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers.,
第82回日本循環器学会, Mar. 2018. Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Growth of Vasa Vasorum is Associated with Local Inflammation around Coronary Plaque in Fresh Cadavers(和訳中),
日本循環器学会学術集会抄録集, PJ007-3, Mar. 2018. Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel(和訳中),
日本循環器学会学術集会抄録集, PJ022-1, Mar. 2018. Yutaka Kawabata, Takeshi Soeki, Takayuki Ise, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Effects of L-/N-type Calcium Channel Blocker on Proteinuria and Angiotensin II-renin Feedback in Hypertensive Patients(和訳中),
日本循環器学会学術集会抄録集, PJ067-4, Mar. 2018. AINI KUNDUZIAYI, 福田大受, 八木秀介, 添木武, 佐田政隆 :
Combination of vildagliptin,a DPP-4 Inhibitor, and metformin have additive beneficial effects on endothelial function and atherogenesis in non-diabetic apolipoprotein-E deficient mice,
日本老年医学会四国地方会, 2018年2月. GANBAATAR BYAMBASUREN, 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Ticagrelor, a P2Y12 antagonist, prevents endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice,
脳心血管抗加齢研究会2017, 2017年12月. AINI KUNDUZIAYI, 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Atheroprotective effects of Linagliptin, a DPP-4 inhibitor, in normoglycemic ApoE/mice,
脳心血管抗加齢研究会2017, 2017年12月. Ganbaatar Byambasuren, Daiju Fukuda, Salim Masdan Hotimah, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Ticagrelor, a P2Y12 Antagonist, Attenuates Vascular Dysfunction and Inhibits Atherogenesis in Apolipoprotein-E-deficient Mice,
CVMW2017, Dec. 2017. Aini Kunduziayi, Daiju Fukuda, Salim Masdan Hotimah, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
DPP-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice,
CVMW2017, Dec. 2017. 高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 佐田政隆 :
ω3系不飽和脂肪酸の抗動脈硬化作用,
CVMW2017, 2017年12月. 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
直接的トロンビン阻害薬であるダビガトランは糖尿病性血管内皮機能障害を改善する,
CVMW2017, 2017年12月. 志村拓哉, 西條良仁, 山口浩司, 楠瀬賢也, 山田博胤, 瀬野弘光, 數藤久美子, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈血栓症の誘因となる下肢血流障害の検討-下肢静脈造影での検討-,
第111回日本循環器学会四国地方会, 2017年12月. 豊田直人, 轟貴史, 添木武, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 福田大受, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
診断から40年後に治療しえた著明なBroad Kent束を有するWPW症候群の一例,
第111回日本循環器学会四国地方会, 2017年12月. 中野睦基, 川端豊, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 數藤久美子, 西條良仁, 上野理絵, 伊藤浩敬, 轟貴史, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
嚥下性失神に対して高級性ペースメーカー植え込み術が有効であった1例,
第111回日本循環器学会四国地方会, 2017年12月. 矢野哲弘, 松浦朋美, 數藤久美子, 瀬野弘光, 西條良仁, 上野理絵, 川端豊, 伊藤浩敬, 轟貴史, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後の医原性心房中隔欠損残存により右心不全症状をきたした一例,
第111回日本循環器学会四国地方会, 2017年12月. 川端豊, 若槻哲三, 山口浩司, 伊藤浩敬, 福田大受, 伊勢孝之, 楠瀬賢也, 松浦朋美, 轟貴史, 廣野明, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
未固定遺体における管脈プラーク性状と局所周囲脂肪内炎症物質との関連,
第65回日本心臓病学会学術集会, 2017年9月. 山口浩司, 若槻哲三, 川端豊, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 伊勢孝之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Biodegradable polymer SESの慢性期局所血管反応の検討-Durable polymer SESとの比較-,
第65回日本心臓病学会学術集会, 2017年9月. 轟貴史, 八木秀介, 楠瀬賢也, 伊勢孝之, 西條良仁, 瀬野弘光, 廣野明, 松浦朋美, 福田大受, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
膠原病患者での肺動脈楔入圧と左室拡張期末期圧の関係,
第65回日本心臓病学会学術集会, 2017年9月. 平田有紀奈, 楠瀬賢也, 山田博胤, 桒畑絢也, 鳥居裕太, 天野里江, 西尾進, 瀬野弘光, 西條良仁, 瀬野弘光, 八木秀介, 添木武, 佐田政隆 :
フルマラソンが心房機能に与える影響について∼，心エコー図検査を用いた検討∼,
第65回日本心臓病学会学術集会, 2017年9月. 若槻哲三, 山口浩司, 福田大受, 川端豊, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
微小管腔構造を認める冠動脈壁の組織性状の評価-未固定遺体における検討-,
第65回日本心臓病学会学術集会, 2017年9月. Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijoh, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Preload Stress Echocardiography Predicts Outcomes in Patients with Pre-served Ejection Fraction and Low Gradient Aortic Stenosis,
第65回日本心臓病学会学術集会, Sep. 2017. 荒瀬美晴, 飛梅威, 伊藤浩敬, 松浦朋美, 添木武, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬物療法の継続が困難で頻脈誘発性心筋症を生じたが，カテーテルアブレーションにて合併症なく根治に成功した洞房リエントリー性頻拍の1例,
第255回徳島医学会学術集会, 2017年8月. 瀬野弘光, 添木武, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆 :
計算負荷試験で誘発された心室性期外収縮の一例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 伊藤浩敬, 飛梅威, 添木武, 大櫛祐一郎, 瀬野弘光, 西條良仁, 川端豊, 轟貴史, 廣野明, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
左鎖骨下への植え込み型除細動器植え替え後に生じたTwiddler症候群の1例,
第110回日本循環器学会中国・四国合同地方会, 2017年6月. 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 八木秀介, 飛梅威, 山田博胤, 添木武, 川谷洋平, 荒瀬裕己, 黒部裕嗣, 藤本鋭貴, 北川哲也, 佐田政隆 :
肺癌術前にバルーン大動脈弁形成術を施行し良好な開大が得られた重症大動脈弁狭窄症の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 西條良仁, 山田博胤, 楠瀬賢也, 西尾進, 大櫛祐一郎, 瀬野弘光, 原知也, 川端豊, 伊藤浩敬, 轟貴史, 廣野明, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 黒部裕嗣, 渡邉俊介, 佐田政隆 :
著名な心内膜肥厚を認めた acromegalic cardiomyopathy の一例,
第110回日本循環器学会中国・四国地方会, 2017年6月. 楠瀬賢也, 山田博胤, 林修司, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー図の再検査によりVegetationを同定しえた感染性心内膜炎の1例,
日本内科学会第116回四国地方会, 2017年5月. GANBAATAR BYAMBASUREN, 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Ticagrelor, a P2Y21 inhibitor, attenuated vascular dysfunction and inhibited atherogenesis in apolipoprotein-E-deficient mice,
第17回日本NO学会学術集会, 2017年5月. AINI KUNDUZIAYI, 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice,
第17回日本NO学会学術集会, 2017年5月. GANBAATAR BYAMBASUREN, 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Canagliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction and atherogenesis in diabetic mice,
第17回日本NO学会学術集会, 2017年5月. 福田大受, Hotimah Masdan Salim, 八木秀介, 添木武, 佐田政隆 :
Dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice,
第17回日本NO学会学術集会, 2017年5月. Gulinu Maimaituxun, 島袋充生, 平田有紀奈, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 原田雅史, 佐田政隆 :
Epicardial adipose tissue thickness in left anterior descending artery predictict coronary atherosclerosis,
第17回日本NO学会学術集会, 2017年5月. 大櫛祐一郎, 楠瀬賢也, 瀬野弘光, 西條良仁, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 添木武, 佐田政隆 :
左房圧上昇評価における新しいASEガイドラインによる評価法と従来の包括的評価法との比較,
日本心エコー図学会第28回学術集会, 2017年4月. 西條良仁, 山田博胤, 楠瀬賢也, 大櫛祐一郎, 瀬野弘光, 平田有紀奈, 鳥居裕太, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
心房収縮期僧帽弁口血流速度の前負荷増大に対する反応性を用いた左房圧上昇の予測,
日本心エコー図学会第28回学術集会, 2017年4月. Hirotsugu Yamada, Kenya Kusunose, 天野里江, 西條良仁, 瀬野弘光, 西尾進, 平田有紀奈, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Sitagliptin on Left Ventricular Function in Patients with Type 2 Diabetes: A Subanalysis of the PROLOGUE Study,
第81回日本循環器学会学術集会, Mar. 2017. 西條良仁, Hirotsugu Yamada, Kenya Kusunose, 西尾進, 瀬野弘光, 大櫛祐一郎, 高木恵理, 上野理絵, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 轟貴史, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of Left Atrial Ischemia on Left Atrial Reservoir Function in Patients with Old Myocardial Infarction,
第81回日本循環器学会学術集会, Mar. 2017. 平田有紀奈, Kenya Kusunose, Hirotsugu Yamada, 清水陸登, 鳥居裕太, 西尾進, 瀬野弘光, 西條良仁, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Quantitative Classification of Left Atrial Appendage is Superior to Visual Classification for Risk Stratification of Stroke in Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 轟貴史, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takayuki Ise, Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serum Level of Lipoprotein (a) is a Risk Factor for Aortic Valve Sclerosis in Women,
第81回日本循環器学会学術集会, Mar. 2017. 大櫛祐一郎, Hirotsugu Yamada, Kenya Kusunose, 西條良仁, 瀬野弘光, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Accuracy of Diagnosis of Elevated Left Atrial Pressure Using Recommendation for the Evaluation of Left Ventricular Diastolic Function by Echocardiograph,
第81回日本循環器学会学術集会, Mar. 2017. 伊勢孝之, 八木秀介, 瀬野弘光, 西條良仁, 高木恵理, 上野理絵, 原知也, 伊藤浩敬, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
Nocturnal Hypoxemia Predicts Cardiac Events in Patients with Cardiac Risk Factors,
第81回日本循環器学会学術集会, 2017年3月. 楠瀬賢也, 山田博胤, 西尾進, 平田有紀奈, 瀬野弘光, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
Right Ventricular Myocardial Strain during Preload Augmentation is Associated with Exercise Capacity in Patients with Chronic Heart Failure,
第81回日本循環器学会学術集会, 2017年3月. Maimaituxun Gulinu, Michio Shimabukuro, Koji Yamaguchi, Shusuke Yagi, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Local Epicardial Adipose Tissue Thickness and Its Impact on Coronary Atherosclerosis,
第81回日本循環器学会学術集会, Mar. 2017. 伊藤浩敬, 若槻哲三, 山口浩司, 福田大受, 川端豊, 轟貴史, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
Lipid-rich Coronary Plaque is Associated with Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadaveric Models,
第81回日本循環器学会学術集会, 2017年3月. Tetsuzo Wakatsuki, Koji Yamaguchi, 伊藤浩敬, Daiju Fukuda, 川端豊, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
The Tissue Characteristics of Coronary Plaque with Microluminal Structures Identified by OCT Associated with Local Inflammatory Response in Fresh Cadavers,
第81回日本循環器学会学術集会, Mar. 2017. Koji Yamaguchi, Tetsuzo Wakatsuki, 伊藤浩敬, 川端豊, 轟貴史, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Comparison of Local Coagulative Response after Coronary Angioplasty - First Generation DES vs Second Generation-DES vs Drug Coated Balloon -,
第81回日本循環器学会学術集会, Mar. 2017. 瀬野弘光, Kenya Kusunose, Hirotsugu Yamada, 西條良仁, 西尾進, 平田有紀奈, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Comparison of Right Ventricular Global Longitudinal Strain between Vender-dependent and Vender-independent Two-dimensional Speckle Tracking Software,
第81回日本循環器学会学術集会, Mar. 2017. 谷口実佑, Takeshi Soeki, Tomomi Matsuura, 佐藤裕紀, Takeshi Tobiume, 原知也, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation,
第81回日本循環器学会学術集会, Mar. 2017. 上田浩之, 瀬野弘光, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
ベバシズマブ併用化学療法中に深部静脈血栓症および肺塞栓症を来した大腸癌の1例-血栓素因の検討も含めて,
第254回徳島医学会学術集会, 2017年2月. 西山美月, 飛梅威, 松浦朋美, 添木武, 佐田政隆 :
左鎖骨下への植込み型除細動器植え替え後に生じたTwiddler症候群の1例,
第254回徳島医学会学術集会, 2017年2月. 山本清成, 轟貴史, 大櫛祐一郎, 上野理恵, 伊勢孝之, 瀬野弘光, 西條良仁, 高木恵理, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 松浦朋美, 飛梅威, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 門田友里, 西村正人, 苛原稔 :
PET/CTにて診断できた心サルコイドーシスの1例,
第254回徳島医学会学術集会, 2017年2月. 笠井明成, 原知也, 山田博胤, 添木武, 若槻哲三, 足立克仁, 佐田政隆 :
著明な刺激伝導系異常を呈したBecker型筋ジストロフィーの1例,
第254回徳島医学会学術集会(平成28年度冬期), 2017年2月. 添木武 :
心臓リハビリテーションのためのデバイス基礎知識,
日本心臓リハビリテーション学会第1回四国支部地方会, 2017年1月. Maimaituxun Gulinu, 島袋充生, 平田有紀奈, 岩瀬俊, 髙尾正一郎, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 田端実, 森本喜久, 赤坂武, 田中正史, 高梨秀一郎, 佐田政隆 :
心臓バイパス手術症例におけるリスク要因の定量的解析:古典的および非古典的リスクの性差,
脳心血管抗加齢研究会2016, 2016年12月. Gulinu Maimaituxun, 島袋充生, 平田有紀奈, 岩瀬俊, 高尾正一郎, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
局所心臓周囲脂肪厚の臨床的意義:冠動脈疾患での検討,
脳心血管抗加齢研究会2016, 2016年12月. 鈴木聖也, 山田博胤, 高木恵理, 高川由利子, 松浦朋美, 伊勢孝之, 平田有紀奈, 楠瀬賢也, 西條良仁, 瀬野弘光, 大櫛祐一郎, 西尾進, 山尾雅美, 鳥居裕太, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
経食道心エコー検査により原因が究明された高齢発症の右心不全の1例,
第109回日本循環器学会四国地方会, 2016年12月. 高木恵理, 八木秀介, 伊勢孝之, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 高川由利子 :
右心不全の精査の過程で偶発的に見つかった冠静脈洞閉鎖および重複上大静脈の一例,
第109回日本循環器学会四国地方会, 2016年12月. 上田浩之, 瀬野弘光, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 添木武, 東島潤, 佐田政隆 :
Bevacizumab併用化学療法中に深部静脈血栓症および肺塞栓症を発症した1例,
第109回日本循環器学会四国地方会, 2016年12月. 行重佐和香, 楠瀬賢也, 瀬野弘光, 西條良仁, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
成人期に心不全症状を契機に発見された左室緻密化障害の一例,
第109回日本循環器学会四国地方会, 2016年12月. ロバートゼング, 西條良仁, 楠瀬賢也, 山田博胤, 轟貴史, 西尾進, 瀬野弘光, 高木恵理, 上野理絵, 原知也, 川端豊, 齋藤友子, 伊藤浩敬, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
左上肢脱力を主訴に来院されたが心エコー図法を契機に急性冠症候群と診断しえた一例,
第109回日本循環器学会四国地方会, 2016年12月. 岡本恵暢, 原知也, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1家系,
日本内科学会第115回四国地方会, 2016年11月. 本間友佳子, 早渕康信, 小野朱美, 香美祥二, 井上美紀, 森一博, 佐田政隆, 添木武, 飛梅威, 松浦朋美 :
Left venous valve由来部位の異常自動能が示唆された右房後中隔起源の心房頻拍・頻拍誘発性心筋症の1女児例,
第21回日本小児心電学会学術集会, 2016年11月. 松浦朋美, 添木武, 飛梅威, 佐田政隆 :
右房低位中隔部に電気的不連続性を認めた通常型心房粗動の1例,
カテーテルアブレーション関連秋季大会2016, 2016年10月. 大櫛祐一郎, 楠瀬賢也, 西條良仁, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 添木武, 佐田政隆 :
運動負荷心エコー図検査で肺高血圧症を診断しえた一例,
日本超音波医学会第26回四国地方会学術集会, 2016年10月. 八木秀介, 伊勢孝之, 西川幸治, 石井亜由美, 楠瀬賢也, 山口浩司, 松浦朋美, 飛梅威, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全患者に対するAdaptive servo-ventilation装着下6分間歩行における運動耐容能改善効果,
第64回日本心臓病学会学術集会, 2016年9月. 鈴川理乃, 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 衣川尚知, 平田有紀奈, 天野里江, 鳥居裕太, 山尾雅美, 西尾進, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
持続性心房細動の肺静脈隔離術後における左房機能の回復と再発との関連,
第64回日本心臓病学会学術集会, 2016年9月. 瀬野弘光, 楠瀬賢也, 山田博胤, 西條良仁, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
心血管イベント発症高リスク患者における非侵襲的血管機能検査の有用性,
第64回日本心臓病学会学術集会, 2016年9月. 添木武, 高橋甲介, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心筋虚血再灌流障害に対する新たな治療薬としてのC型ナトリウム利尿ペプチドの可能性,
第64回日本心臓病学会学術集会, 2016年9月. 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 西尾進, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
下肢陽圧負荷心エコー検査により将来の左房圧上昇を予測できるか,
第64回日本心臓病学会学術集会, 2016年9月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2016年6月. 原知也, 山田博胤, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
重症心不全を呈したBecker型筋ジストロフィーの1剖検例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 原知也, 飛梅威, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心房細動アブレーション後に麻痺性胃拡張を来した一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 伊勢孝之, 八木秀介, 門田宗之, 瀬野弘光, 西條良仁, 上野理絵, 原知也, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
循環器病棟入院患者における睡眠時無呼吸，夜間低酸素血症の合併 ∼連続パルスオキシメータを用いた解析∼,
第108回日本循環器学会中国・四国合同地方会, 2016年6月. 本間友佳子, 森一博, 藤岡啓介, 佐々木亜由美, 寺田知正, 永井隆, 井上美紀, 早渕康信, 小野朱美, 香美祥二, 佐田政隆, 添木武, 飛梅威, 松浦朋美 :
持続する全身倦怠感を主訴とした異所性心房頻拍に伴う頻拍誘発性心筋症の1女児例,
第146回日本小児科学会徳島地方会, 2016年6月. 西條良仁, 山田博胤, 楠瀬賢也, 林修司, 鳥居裕太, 天野里江, 山尾雅美, 西尾進, 添木武, 佐田政隆 :
ハンドグリップ負荷心エコー検査が有用であった心房細動合併慢性心不全の1例,
日本超音波医学会第89回学術集会, 2016年5月. 松浦朋美, 添木武, 飛梅威, 上野理絵, 坂東左知子, 山田博胤, 若槻哲三, 佐田政隆, 早渕康信, 小野朱美 :
心房中隔起源の持続性心房頻拍により頻脈誘発性心筋症をきたした小児の1例,
日本内科学会第114回四国地方会, 2016年5月. 伊藤浩敬, 若槻哲三, 山口浩司, 伊勢孝之, 上野理絵, 齋藤友子, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めその後も増大を呈した1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ペースメーカー植込み術後に等容拡張期の異常な左室中部流入血流を認めた1例,
日本内科学会第114回四国地方会, 2016年5月. 西條良仁, 山田博胤, 楠瀬賢也, 瀬野弘光, 伊勢孝之, 八木秀介, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷心エコー検査が心房細動合併心不全の治療評価に有用であった1例,
日本内科学会第114回四国地方会, 2016年5月. 楠瀬賢也, 山田博胤, 瀬野弘光, 西條良仁, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
弁膜症・肺高血圧症で使いこなす,
日本心エコー図学会第27回学術集会, 2016年4月. 山田博胤, 楠瀬賢也, 西條良仁, 瀬野弘光, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
肺高血圧症に対する負荷心エコー検査,
日本心エコー図学会第27回学術集会, 2016年4月. Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Mika Bando, T Hara, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, M Kadota, R Ueno, Mika Bando, H Yamazaki, Y Saito, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Local Vascular Response after Paclitaxel Eluting Balloon Angioplasty Compared to Drug Eluting Stent Implantation in Stable Angina Patients.,
第80回日本循環器学会学術集会, Mar. 2016. S Bando, Takeshi Soeki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Plasma Myeloperoxidase Activity is Associated with Atrial Substrate Remodeling in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice through GLP-1 Dependent Manner.,
第80回日本循環器学会学術集会, Mar. 2016. Michio Shimabukuro, Hirotsugu Yamada, Hirotsugu Kurobe, Y Hirata, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa and Masataka Sata :
Ezetimibe Reduces Epicardial Fat and Improves Cardiac Performance in Swine Fed a High-fat Diet: A Pathophysiological Role of Oxidized Cholesterols.,
第80回日本循環器学会学術集会, Mar. 2016. Tomomi Matsuura, Takeshi Soeki, Y Morimoto, S Bando, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Epicardial Adipose Tissue Produce Proinflammatory Cytokines and Influence the Pathogenesis of Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Michio Shimabukuro, HM Salim, T Hara, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Antagonism of Protease-activated Receptor 2 (PAR-2) Recovers Endothelial Dysfunction in Diabetic Mice.,
第80回日本循環器学会学術集会, Mar. 2016. Y Hirata, Kenya Kusunose, Hirotsugu Yamada, Y Torii, S Nishio, Mika Bando, S Hayashi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Structural Remodeling of Left Atrial Appendage in Patients with Atrial Fibrillation.,
第80回日本循環器学会学術集会, Mar. 2016. Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Deletion of Toll-Like Receptor 9 Prevented Atherosclerosis Induced by Angiotensin II.,
第80回日本循環器学会学術集会, Mar. 2016. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Critical Role in Bone Marrow Protease-Activated Receptor-2 in the Pathogenesis of Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.,
第80回日本循環器学会学術集会, Mar. 2016. Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Cell-Free DNA/Toll-like Receptor 9 Axis Plays a Pivotal Role in Metabolic Disorder-induced Chronic Inflammation, Leading to Atherogenesis and Insulin Resistance.,
第80回日本循環器学会学術集会, Mar. 2016. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Y Hirata, H Seno, Y Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, B Griffin and Masataka Sata :
Echocardiographic Characteristics of Right Ventricular Size and Function are Associated with Cardiac Events in Sleep Apnea Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. 加藤悠人, 飛梅威, 小島義裕, 川端豊, 仁木敏之, 岡村暢大, 竹谷善雄, 坂東左知子, 松浦朋美, 添木武, 佐田政隆 :
His束近傍に起源を認めるATP感受性心房頻拍7例に関する検討,
第252回徳島医学会学術集会(平成27年度冬期), 2016年2月. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群発症時のイコサペント酸とドコサヘキサエン酸の血中濃度低下は慢性期冠動脈ステント内再狭窄の予測因子である,
第45回日本心脈管作動物質学会, 2016年2月. 高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明,
第45回日本心脈管作動物質学会, 2016年2月. Salim Masdan Hotimah, Daiju Fukuda, 東邦康智, 田中君枝, 平田陽一郎, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in apolipoprotein-E deficient mice through GLP-1 dependent and independent manners.,
第45回日本心脈管作動物質学会, Feb. 2016. 坂東左知子, 添木武, 寒川賢治, 佐田政隆 :
非心不全担癌患者におけるBNPの動態,
第45回日本心脈管作動物質学会, 2016年2月. 西本幸子, 福田大受, 東邦康智, 田中君枝, 平田陽一郎, 八木秀介, 添木武, 阪上浩, 島袋充生, 佐田政隆 :
動脈硬化におけるマクロファージTLR9の役割,
第45回日本心脈管作動物質学会, 2016年2月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆 :
プロテアーゼ活性化受容体2によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第45回日本心脈管作動物質学会, 2016年2月. 上田雄大, 島袋充生, Maimaituxun Gulinu, Salim Masdan Hotimah, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
冠症候群発症例における心臓周囲脂肪および腹部脂肪分布の検討,
第45回日本心脈管作動物質学会, 2016年2月. Maimaituxun Gulinu, 島袋充生, Salim Masdan Hotimah, 松浦朋美, 八木秀介, 福田大受, 山田博胤, 添木武, 田端実, 森本喜久, 赤坂武, 田中正史, 高梨秀一郎, 佐田政隆 :
冠動脈疾患と心臓周囲脂肪量:男女差の検討,
第45回日本心脈管作動物質学会, 2016年2月. 六車隆太郎, 福田大受, 島袋充生, 東邦康智, 田中君枝, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆 :
TLR9の活性化は虚血肢における炎症を増強し血流改善を遅延させる,
第45回日本心脈管作動物質学会, 2016年2月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆 :
FXa - PAR-2経路は血管の慢性炎症を惹起し動脈硬化を促進する,
CVMW 2015, 2015年12月. 橋本怜, 島袋充生, Salim Masdan Hotimah, 原知也, 福田大受, 八木秀介, 添木武, 阪上浩, 佐田政隆 :
糖尿病性血管障害におけるPAR2シグナルの関与,
CVMW 2015, 2015年12月. G Maimaituxun, Michio Shimabukuro, HM Salim, Tomomi Matsuura, Shusuke Yagi, D Fukuda, Hirotsugu Yamada, Takeshi Soeki, M Tabata, Y Morimoto, T Akasaka, M Tanaka, S Takanashi and Masataka Sata :
EATV is determinant for coronary atherosclerosis in men, but not in women: Analysis from patients underwent coronary artery bypass surgery.,
CVMW 2015, Dec. 2015. HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata :
Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice.,
CVMW 2015, Dec. 2015. 福田大受, 西本幸子, 東邦康智, 田中君枝, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆 :
自己遊離核酸断片の認識を介した血管の炎症と動脈硬化発症メカニズム,
CVMW 2015, 2015年12月. 上野理絵, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
当院で出産まで管理しえた心室頻拍合併妊娠の2症例,
日本内科学会第113回四国地方会, 2015年12月. 伊勢孝之, 西條良仁, 三木浩和, 賀川久美子, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 伊藤浩敬, 松浦朋美, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 添木武, 若槻哲三, 安倍正博, 佐田政隆 :
auto-PBSCT とBortezomibの併用が著効した高度心機能障害を伴う原発性心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 門田宗之, 伊勢孝之, 楠瀬賢也, 瀬野弘光, 上野理絵, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山﨑宙, 坂東左知子, 伊藤浩敬, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
静脈洞型心房中隔欠損を合併した高齢難治性心不全に対し修復術が奏功した一例,
第107回日本循環器学会四国地方会, 2015年11月. 坂東左知子, 添木武, 松浦朋美, 飛梅威, 瀬野弘光, 西條良仁, 門田宗之, 原知也, 上野理絵, 齋藤友子, 坂東美佳, 山﨑宙, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
心室瘤を形成した心サルコイドーシス患者の薬剤抵抗性VT storm に対しアブレーションを行った一例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 坂東美佳, 楠瀬賢也, 門田宗之, 伊勢孝之, 山田博胤, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
ハンドグリップ負荷による心臓カテーテル検査および心エコー検査が治療評価に有用であった2例,
第107回日本循環器学会四国地方会, 2015年11月. 伊藤浩敬, 高島啓, 八木秀介, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 山口浩司, 飛梅威, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症筋無力症に対する免疫抑制療法中に生じた化膿性心膜炎の一例,
第107回日本循環器学会四国地方会, 2015年11月. 西條良仁, 齋藤友子, 山田博胤, 楠瀬賢也, 坂東美佳, 瀬野弘光, 門田宗之, 原知也, 上野理絵, 山﨑宙, 坂東左知子, 伊藤浩敬, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
遅延造影MRI検査が診断の契機となった心アミロイドーシスの1例,
第107回日本循環器学会四国地方会, 2015年11月. 山下雄也, 伊勢孝之, 坂東美佳, 原知也, 高島啓, 山﨑宙, 齋藤友子, 坂東左知子, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 佐田政隆 :
60歳代で発見され外科治療が奏功した大動脈縮窄症の1例,
第107回日本循環器学会四国地方会, 2015年11月. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群患者におけるスタチンのω3不飽和脂肪酸濃度へ影響,
第107回日本循環器学会四国地方会, 2015年11月. 加藤悠人, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 瀬野弘光, 上野理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊藤浩敬, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
His束近傍に起源を認めるATP感受性心房頻拍7例に関する検討,
第107回日本循環器学会四国地方会, 2015年11月. M Kadota, Takayuki Ise, Shusuke Yagi, Kenya Kusunose, Hajime Kinoshita, Hirotsugu Kurobe, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Successful Surgical Repair of Aged Sinus Venous Connection : A Case Report,
第19回日本心不全学会学術集会, Oct. 2015. 坂東左知子, 飛梅威, 添木武, 松浦朋美, 佐田政隆 :
僧房弁輪後壁での通電にて治療に成功したLeft variant型房室結節リエントリー性頻拍の1例,
カテーテルアブレーション関連秋季大会2015, 2015年10月. 飛梅威, 竹谷善雄, 小島義裕, 川端豊, 仁木敏之, 岡村暢大, 坂東左知子, 松浦朋美, 添木武, 佐田政隆 :
下壁誘導でtall R・V1でqrS patternを認めた右室流出路中隔起源心室性期外収縮の1例,
カテーテルアブレーション関連秋季大会2015, 2015年10月. 鈴川理乃, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 楠瀬賢也, 林修司, 添木武, 佐田政隆 :
高齢で心アミロイドーシスを発症した肥大型心筋症の一例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 西條良仁, 山田博胤, 楠瀬賢也, 林修司, 坂東美佳, 天野里江, 西尾進, 山尾雅美, 添木武, 佐田政隆 :
等容拡張期に異常な左室中部流入血流を認めたペースメーカー植込み術後の1例,
日本超音波医学会第25回四国地方会学術集会, 2015年10月. 伊勢孝之, 若槻哲三, 山口浩司, 坂東美佳, 門田宗之, 八木秀介, 山田博胤, 添木武, 佐田政隆 :
PTSMA術後に左室流出路狭窄の急性増悪を認めたHOCMの1例,
ストラクチャークラブ・ジャパンライブデモンストレーション2015, 2015年9月. 長野広実, 添木武, 坂東左知子, 松浦朋美, 飛梅威, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動発症の予測因子-心電学的側面と心エコー学的側面からの検討-,
第63回日本心臓病学会学術集会, 2015年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 若槻哲三, 佐田政隆 :
薬剤抵抗性のPurkinje起源心室頻拍に対し，人工呼吸管理・PCPS装着下にカテーテルアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第63回日本心臓病学会学術集会, 2015年9月. 瀬野弘光, 山田博胤, 楠瀬賢也, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 伊勢孝之, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
6分間歩行負荷心エコー検査を用いた運動負荷誘発性肺高血圧症例の検出とその特徴,
第63回日本心臓病学会学術集会, 2015年9月. 平田有紀奈, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 山尾雅美, 坂東美佳, 林修司, 楠瀬賢也, 山口浩司, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
冠動脈疾患の非侵襲的診断における心臓周囲脂肪厚の付加的価値,
第63回日本心臓病学会学術集会, 2015年9月. 伊勢孝之, 楠瀬賢也, 松浦朋美, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急性心筋梗塞後にBeckerⅠ型とⅢ型の心破裂をきたし，救命しえた一例,
第63回日本心臓病学会学術集会, 2015年9月. 坂東美佳, 伊勢孝之, 山田博胤, 楠瀬賢也, 西尾進, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈縮窄症の1例,
第63回日本心臓病学会学術集会, 2015年9月. 山田亮, 原知也, 八木秀介, 東島潤, 山田博胤, 添木武, 若槻哲三, 島田光生, 佐田政隆 :
下肢静脈血栓症を伴わない下大静脈限局型血栓症の1例,
第251回徳島医学会学術集会(平成27年度夏期), 2015年8月. 本田壮一, 白川光雄, 小原聡彦, 伊藤祐司, 井内貴彦, 東博之, 安部あかね, 坂東弘康, 添木武, 佐田政隆 :
ワルファリン・コントロール良好にもかかわらず出血を合併した心房細動の2症例,
第251回徳島医学会学術集会(平成27年度夏期), 2015年8月. Takeshi Tobiume, S Bando, Tomomi Matsuura, Takeshi Soeki and Masataka Sata :
Efficacy of CATHPAX AF for the reduction of radiation exposure during ablation of atrial fibrillation.,
第30回日本不整脈学会・第32回日本心電学会, Jul. 2015. S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume and Masataka Sata :
Successful catheter ablation of VT/VF triggered by PVC in acute phase of myocardial infarction.,
第30回日本不整脈学会・第32回日本心電学会, Jul. 2015. 高島啓, 門田宗之, 山口浩司, 原知也, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
IgA腎症の加療中に若年で発症した急性冠症候群の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 山口浩司, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
右心不全を来した収縮性心膜炎合併心膜嚢胞の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 鳥居裕太, 天野里江, 西尾進, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
深部静脈血栓症に対するエドキサバンの凝固因子に与える影響,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 山﨑宙, 八木秀介, 原知也, 高島啓, 坂東美佳, 齋藤友子, 坂東左知子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
家族性アミロイドポリニューロパチーを合併した心肥大の一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 坂東左知子, 添木武, 原知也, 齋藤友子, 坂東美佳, 山﨑宙, 高島啓, 松浦朋美, 伊勢孝之, 楠瀬賢也, 山口浩司, 飛梅威, 八木秀介, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Brugada症候群に閉塞性肥大型心筋症を併発した一例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 八木秀介, 山﨑宙, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
肺アスペルギルス症に合併した肺動静脈血栓症の1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 瀬野弘光, 坂東美佳, 楠瀬賢也, 山田博胤, 高川由利子, 林修司, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 平田有紀奈, 西尾進, 島袋充生, 佐田政隆 :
CHADS2スコア低値例における左心耳機能の検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 齋藤友子, 原知也, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果について,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, ブライアングリフィン, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
睡眠時呼吸障害患者の右室機能評価は予後予測において有用である,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 上野理絵, 坂東美佳, 山田博胤, 楠瀬賢也, 高川由利子, 瀬野弘光, 門田宗之, 原知也, 齋藤友子, 山﨑宙, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
間質性肺炎合併膠原病性肺高血圧症にボセンタンが奏功した1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 鈴川理乃, 高川由利子, 坂東美佳, 林修司, 阿部美保, 坂東左知子, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
心房細動に対する肺静脈隔離術後における洞調律維持の予測∼心エコー検査を用いた検討∼,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 鈴木智子, 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
IGg4関連疾患に伴う巨大冠動脈瘤および冠動脈周囲偽腫瘍を認めた1例,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 楠瀬賢也, 山田博胤, 坂東美佳, 西條良仁, 西尾進, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
膠原病に伴う肺高血圧症の悪化予測:6分間歩行負荷心エコー図検査を用いた検討,
第106回日本循環器学会中国・四国合同地方会, 2015年6月. 原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山﨑宙, 若槻哲三, 山口浩司, 八木秀介, 山田博胤, 添木武, 佐田政隆, 鹿草宏, 里見淳一郎, 永廣信治 :
広範前壁心筋梗塞発症早期に左心室内血栓を生じた2例,
第2回日本心血管脳卒中学会学術集, 2015年6月. 坂東左知子, 松浦朋美, 添木武, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
感染性心内膜炎から多発性脳塞栓発症により死亡に至った一例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動カテーテルアブレーションにおける放射線防護キャビンの放射線被爆低減効果に関する検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 平田有紀奈, 山田博胤, 楠瀬賢也, 西尾進, 山尾雅美, 坂東美佳, 松浦朋美, 飛梅威, 添木武, 佐田政隆 :
心房細動に対する肺静脈隔離術後における洞調律維持の予測:経胸壁および3次元経食道心エコー検査を用いた検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 山下雄也, 坂東美佳, 楠瀬賢也, 宮本亮介, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
片麻痺および間代性痙攣でStroke Care Unit入室後に高度心機能低下をきたした1例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 原知也, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
アトピー性皮膚炎から感染性心内膜炎を来した1例,
日本内科学会第112回四国地方会, 2015年6月. 楠瀬賢也, 山田博胤, 西尾進, 鳥居裕太, 天野里江, 林修司, 添木武, 佐田政隆 :
Automated Function Imaging の左室壁運動定量評価は心エコー初心者の判断の補助となる,
日本超音波医学会第88回学術集会, 2015年5月. 楠瀬賢也, 山田博胤, 西條良仁, 坂東美佳, 林修司, 山尾雅美, 鳥居裕太, 添木武, 佐田政隆 :
運動負荷後の右心機能指標は弁膜症の予後と関連する招待講演,
日本超音波医学会第88回学術集会, 2015年5月. 山田博胤, 楠瀬賢也, 坂東美佳, 林修司, 西尾進, 山尾雅美, 天野里江, 鳥居裕太, 添木武, 佐田政隆 :
左室の壁運動(e')と血流(E)の不整合は左室拡張末期圧の上昇を反映する．,
日本超音波医学会第88回学術集会, 2015年5月. 山田博胤, 楠瀬賢也, 林修司, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 鳥居裕太, 平田有紀奈, 添木武, 佐田政隆 :
心エコー・ドプラ法による左室拡張末期圧の推定は，心房細動でも可能か?,
日本超音波医学会第88回学術集会, 2015年5月. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, Y Takagawa, Mika Bando, A Takashima, H Yamazaki, S Bando, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Local Vascular Responses after Implantation of Biolimus-Eluting and Everolimus-Eluting Stents Compared with Sirolimus-Eluting and Bare Metal Stents.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.,
第79回日本循環器学会学術集会, Apr. 2015. T Hara, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice.,
第79回日本循環器学会学術集会, Apr. 2015. Michio Shimabukuro, Daiju Fukuda, H Sato, S Nishimoto, T Hara, A Takashima, Y Hirata, Hirotsugu Kurobe, Shusuke Yagi, Takeshi Soeki, Hirofumi Izaki, Hiroshi Sakaue, Tetsuya Kitagawa, Hiro-omi Kanayama and Masataka Sata :
Depot- and Gender-Specific Regulation of the Innate Immune System in Adipose Tissues: A Study from Human Biopsy Samples.,
第79回日本循環器学会学術集会, Apr. 2015. Takeshi Soeki, Tomomi Matsuura, S Bando, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, H Yamazaki, Y Saito, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Antiarrhythmic and Antiapoptotic Effects of C-type Natriuretic Peptide in Rats with Myocardial Ischemia/Reperfusion.,
第79回日本循環器学会学術集会, Apr. 2015. 武井美貴子, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 佐田政隆 :
生理的ペーシングへのモード変更が心不全の改善に有効であった房室ブロックの1例,
第7回植込みデバイス関連冬季大会, 2015年2月. 原知也, 福田大受, 田中君江, 東邦康智, 平田陽一郎, 八木秀介, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討,
第44回日本心脈管作動物質学会, 2015年2月. 松本康平, 楠瀬賢也, 松本和久, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
動脈周囲炎をきたしたIgG4関連疾患の1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 鈴木智子, 山崎宙, 近藤彰, 高川由利子, 坂東美佳, 發知淳子, 松浦朋美, 楠瀬賢也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
活動性を評価するにあたりPET-CTが特に有効であった心サルコイドーシスの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 武井美貴子, 飛梅威, 坂東左知子, 松浦朋美, 添木武, 今田久美子, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 山崎宙, 坂東美佳, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
生理的ペーシングへのモード変更が心不全の改善に有効であった房室ブロックの1例,
第250回徳島医学会学術集会(平成26年度冬期), 2015年2月. 今田久美子, 伊勢孝之, 八木秀介, 高木恵理, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 坂東美佳, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性血栓塞栓性肺高血圧症にリオシグアトを使用した1症例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高木恵理, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓MRIガドリニウム遅延造影で検出できなかった心臓サルコイドーシス再燃の一例,
第105回日本循環器学会四国地方会, 2014年12月. 平田有紀奈, 山田博胤, 西尾進, 堀家由貴, 玉井佑里恵, 鳥居祐太, 天野里江, 山尾雅美, 高川由利子, 坂東美佳, 林修司, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコア，心臓周囲脂肪厚と冠動脈硬化の関連:超音波検査を用いた検討,
第105回日本循環器学会四国地方会, 2014年12月. 高島啓, 若槻哲三, 山口浩司, 松本和久, 今田久美子, 高木恵理, 高川由利子, 原知也, 齋藤友子, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
冠動脈完全閉塞性病変の治療後慢性期に形成された二重血行路をOCTで観察し得た一例,
第105回日本循環器学会四国地方会, 2014年12月. 八木秀介, 鳥居祐太, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
突然の片側性下肢腫脹を呈した変形性関節症の2例,
第105回日本循環器学会四国地方会, 2014年12月. 楠瀬賢也, 山田博胤, ポポヴィッチゾラン, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
無症候性僧帽弁逆流症と大動脈弁逆流症の自然経過,
第105回日本循環器学会四国地方会, 2014年12月. 坂東左知子, 添木武, 今田久美子, 松本和久, 原知也, 高島啓, 山﨑宙, 坂東美佳, 齋藤友子, 松浦朋美, 伊勢孝之, 楠瀬賢也, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
右室流出路心外膜起源が疑われた突発性心室期外収縮の一例,
第105回日本循環器学会四国地方会, 2014年12月. 稲垣太造, 八木秀介, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
治療抵抗性本態性高血圧に対する利尿剤の効果-インダパミドが効果的であった2例の検討-,
第105回日本循環器学会四国地方会, 2014年12月. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の1例,
第105回日本循環器学会四国地方会, 2014年12月. 伊勢孝之, 岩瀬俊, 高川由利子, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓サルコイドーシス再燃に対してメトトレキサートの併用が有効であった1例,
第111回日本内科学会四国地方会, 2014年11月. 八木秀介, 粟飯原賢一, 赤池雅史, 添木武, 佐田政隆 :
血清PTH濃度は高血圧の発症と関連する,
第37回日本高血圧学会総会, 2014年10月. 松浦朋美, 添木武, 西條良仁, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
筋強直性ジストロフィーに伴い二次性心筋症と心房頻拍を呈し，カテーテルアブレーションを施行した一例,
第62回日本心臓病学会学術集会, 2014年9月. 平田有紀奈, 山田博胤, 西尾進, 楠瀬賢也, 澤田直子, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
心エコー法で計測する前室間溝心外膜脂肪厚はCTで計測した心外膜脂肪容積を反映する,
第62回日本心臓病学会学術集会, 2014年9月. 發知淳子, 山田博胤, 西條良仁, 坂東美佳, 高島啓, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
薬剤抵抗性起立性調節障害に対する携帯型下肢陽圧装置の効果,
第62回日本心臓病学会学術集会, 2014年9月. 西尾進, 山田博胤, 楠瀬賢也, 平田有紀奈, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔と各種血管検査指標との関連,
第62回日本心臓病学会学術集会, 2014年9月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP 感受性リエントリー性心房頻拍の2症例,
第62回日本心臓病学会学術集会, 2014年9月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例の検討-OCT による観察から-,
第62回日本心臓病学会学術集会, 2014年9月. 坂東美佳, 山田博胤, 西尾進, 林修司, 發知淳子, 西條良仁, 楠瀬賢也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動症例におけるCHADS2 およびCHA2DS2-VASc スコアと左心耳血流速度の関連,
第62回日本心臓病学会学術集会, 2014年9月. 添木武, 坂東左知子, 松浦朋美, 飛梅威, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるmicroRNAと心房リモデリングおよび予後との関係,
第62回日本心臓病学会学術集会, 2014年9月. 西條良仁, 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 澤田直子, 高川由利子, 平田有紀奈, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁血流速波形の前負荷増大に対する反応性には左房機能が関与する,
第62回日本心臓病学会学術集会, 2014年9月. A Takashima, Daiju Fukuda, K Tanaka, Y Higashikuni, Y Hirata, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Combined administration of eicosapentaenoic acid and docosahexaenoic acid reduces atherosclerotic lesion in apolipoprotein E-deficient mice.,
ESC 2014, Aug. 2014. 富永真由, 伊勢孝之, 坂東美佳, 今田久美子, 松本和久, 高川由利子, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
超選択的コントラストエコーを併用し経皮的中隔心筋焼灼術を有効に施行し得た閉塞性肥大型心筋症の一例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. 亀田香奈子, 伊勢孝之, 西條良仁, 今田久美子, 松本和久, 高川由利子, 高木恵理, 原知也, 齋藤友子, 高島啓, 山﨑宙, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 近藤剛, 佐田政隆 :
原発性アルドステロン症患者に高度冠攣縮を合併し心筋梗塞を発症した1症例,
第249回徳島医学会学術集会(平成26年度夏期), 2014年7月. S Bando, Takeshi Soeki, Takeshi Tobiume, Tomomi Matsuura and Masataka Sata :
Radiofrequency ablation of idiopathic premature ventricular contraction originating from the anterior papillary muscle in the left ventricle.,
第29回日本不整脈学会・第31回日本心電学会合同学術大会, Jul. 2014. Tomomi Matsuura, Takeshi Soeki, Takeshi Tobiume, S Bando and Masataka Sata :
A case of myotonic dystrophy presenting with atrial tachycardia and heart failure.,
第29回日本不整脈学会・第31回日本心電学会合同学術大会, Jul. 2014. Takeshi Soeki, S Bando, Tomomi Matsuura, Takeshi Tobiume and Masataka Sata :
Electrophysiological correlation and prognostic impact of pentraxin 3 as a local inflammatory marker in atrial fibrillation.,
第29回日本不整脈学会・第31回日本心電学会合同学術集会, Jul. 2014. 西條良仁, 伊勢孝之, 三木浩和, 賀川久美子, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 山口浩司, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 奥村宇信, 藤永裕之, 佐田政隆 :
高度心機能障害を伴う原発性心アミロイドーシスに対しauto-PBSCTを施行し得た一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 澤田直子, 高川由利子, 發知淳子, 西條良仁, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心エコー検査による大動脈弁逆流の重症度判定が困難であった大動脈弁位生体弁機能不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 八木秀介, 伊勢孝之, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
大動脈解離の急性期降圧療法における経皮吸収型β1遮断薬の使用経験,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 鳥居裕太, 山田博胤, 西尾進, 平田有紀奈, 天野里江, 山尾雅美, 高川由利子, 西條良仁, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
遺残坐骨動脈奇形に伴う浅大腿動脈閉塞の1例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 今田久美子, 松本和久, 高木恵理, 西條良仁, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ATP感受性リエントリー性心房頻拍の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松浦朋美, 添木武, 松本和久, 今田久美子, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 坂東左知子, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
心房頻拍と心不全を契機に発覚した筋強直性ジストロフィーの一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 阪田美穂, 早渕康信, 井上美紀, 森一博, 木下学, 佐田政隆 :
薬剤抵抗性特発性心室頻拍に対し，PCPS下にアブレーション治療を施行し，社会復帰に成功した若年例の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 松本和久, 若槻哲三, 高島啓, 山口浩司, 西條良仁, 高木恵理, 原知也, 齋藤友子, 高川由利子, 山崎宙, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像と局所凝固反応亢進を認めた一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 若槻哲三, 山口浩司, 伊勢孝之, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
十分な術前ヘパリン置換にもかかわらず超遅発性ステント血栓症を発症した症例-OCTによる観察からの検討-,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 今田久美子, 伊勢孝之, 原知也, 八木秀介, 岩瀬俊, 西條良仁, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全を合併した頻脈性心房細動にランジオロールを有効に使用することができた2症例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 高川由利子, 八木秀介, 山田博胤, 林修司, 發知淳子, 坂東美佳, 山口浩司, 伊勢孝之, 飛梅威, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
母児ともに救命できた母児間輸血症候群と妊娠高血圧腎症に合併した急性心不全の一例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 西尾進, 山田博胤, 真鍋泰毅, 佐藤光代, 平岡葉月, 河野裕美, 平田有紀奈, 天野里江, 西條良仁, 高川由利子, 坂東美佳, 發知淳子, 林修司, 添木武, 若槻哲三, 佐田政隆 :
血流量の増加は%FMDを増大させる,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 原知也, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Vascular endothelial growth factor (VEGF)阻害薬の眼内投与中に急性冠症候群を発症した4症例の検討,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 後東久嗣, 佐田政隆 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 山口浩司, 山田博胤, 若槻哲三, 佐田政隆, 井野口卓, 折野俊介 :
左室前乳頭筋起源の特発性心室性不整脈の1例,
第110回日本内科学会四国地方会, 2014年6月. 齋藤友子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 後東久嗣 :
左室収縮不全と間質性肺炎に伴う肺高血圧症を合併した皮膚筋炎の1例,
第110回日本内科学会四国地方会, 2014年6月. 松浦朋美, 添木武, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房高頻度刺激を行った糖尿病モデルラットにおける直接レニン阻害薬の内皮機能障害抑制効果,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 島袋充生, 松本幸子, 福田大受, 添木武, 山川研, 益崎裕章, 佐田政隆 :
アンジオテンシンⅡタイプ1受容体拮抗薬アジルサルタンは，KKAy糖尿病マウスの炎症シグナル，一酸化窒素合成酵素のリン酸化能を正常化することで血管内皮機能を改善する,
第14回日本NO学会学術集会, 2014年5月. 發知淳子, 山田博胤, 木村恵理子, 坂東美佳, 林修司, 西條良仁, 西尾進, 添木武, 森一博, 佐田政隆 :
収縮期雑音の原因が仮性腱索と考えられた1例:ヴィオリンハート,
第87回日本超音波医学会学術集会, 2014年5月. 天野里江, 山田博胤, 發知淳子, 林修司, 坂東美佳, 西條良仁, 西尾進, 山尾雅美, 添木武, 佐田政隆 :
上行大動脈の拡大が機序の異なる体位変換性呼吸困難に関与したと思われる1例,
第87回日本超音波医学会学術集会, 2014年5月. 山尾雅美, 山田博胤, 西尾進, 平田有紀奈, 鳥居裕太, 天野里江, 高島啓, 發知淳子, 添木武, 佐田政隆 :
冠状静脈洞内に疣腫を認めた冠動静脈瘻の一例,
第87回日本超音波医学会学術集会, 2014年5月. 平尾麻衣子, 山田博胤, 發知淳子, 林修司, 坂東美佳, 西尾進, 山尾雅美, 鳥居裕太, 添木武, 佐田政隆 :
CHADS2およびCHA2DS2-VAScスコアの増加は左心耳血流速度の低下と関連する,
第87回日本超音波医学会学術集会, 2014年5月. 平田有紀奈, 山田博胤, 西尾進, 山尾雅美, 鳥居裕太, 坂東美佳, 林修司, 發知淳子, 西條良仁, 添木武, 若槻哲三, 佐田政隆 :
頸動脈プラークスコアおよび心外膜脂肪厚により冠動脈狭窄が予測できるか?,
第25回日本心エコー図学会学術集会, 2014年4月. 平田有紀奈, Hirotsugu Yamada, 西尾進, 鳥居裕太, 山尾雅美, Mika Bando, 林修司, Junko Hotsuchi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
冠動脈硬化と関連するのはSubepicardial Fat か，Pericardil Fat か,
第78回日本循環器学会学術集会, Mar. 2014. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki and Masataka Sata :
Post-transcriptional regulation of endothelial NADPH oxidase 4 (NOX4) by miR-100: a human biopsy study in subcutaneous and visceral adipose tissue.,
第78回日本循環器学会学術集会, Mar. 2014. Sachiko Matsumoto, Michio Shimabukuro, Daiju Fukuda, T Hara, Takeshi Soeki and Masataka Sata :
Antagonism of protease-activated receptors rescues vascular endothelial function in KK-Ay mice: a novel mechanism of rivaroxaban, a factor Xa inhibitor.,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Matsuura, Takeshi Tobiume, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, Junko Hotsuchi, E Kimura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Atrial late potentials and atrial substrate remodeling in patients with atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki and Masataka Sata :
Post-transcriptional regulation of adiponectin by microRNA 378 in white adipose tissue: a novel mechanism.,
第78回日本循環器学会学術集会, Mar. 2014. S Bando, Takeshi Soeki, T Hara, A Takashima, Mika Bando, K Ogasawara, Y Saito, T Matsuura, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Kenji Kangawa and Masataka Sata :
Ghrelin ameliorates the progression of experimental autoimmune myocarditis.,
第78回日本循環器学会学術集会, Mar. 2014. Koji Yamaguchi, Tetsuzo Wakatsuki, T Hara, K Ogasawara, Mika Bando, A Takashima, S Bando, T Matsuura, Takayuki Ise, Junko Hotsuchi, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential responses of local coagulation after implantation of biolimus-eluting and everolimus-eluting stents compared with sirolimus-eluting and bare metal stents.,
第78回日本循環器学会学術集会, Mar. 2014. Mika Bando, Hirotsugu Yamada, S Nishio, Junko Hotsuchi, S Hayashi, E Kimura, Takayuki Ise, T Matsuura, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Parallel changes in sonographic characteristics of carotid and coronary plaques.,
第78回日本循環器学会学術集会, Mar. 2014. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, A Takashima, Mika Bando, S Bando, T Matsuura, Junko Hotsuchi, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cardiac rehabilitation on oxidized stress in patients with heart failure.,
第78回日本循環器学会学術集会, Mar. 2014. T Matsuura, Takeshi Soeki, R Ota, T Hara, Y Saito, K Ogasawara, A Takashima, Mika Bando, S Bando, Junko Hotsuchi, E Kimura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata :
Increased local production of c-type natriuretic peptide in patients with vasospastic angina.,
第78回日本循環器学会学術集会, Mar. 2014. Takeshi Soeki, S Bando, T Matsuura, Takeshi Tobiume, T Hara, R Ota, A Takashima, Mika Bando, K Ogasawara, Y Saito, Takayuki Ise, Junko Hotsuchi, E Kimura, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.,
第78回日本循環器学会学術集会, Mar. 2014. 阪田美穂, 早渕康信, 香美祥二, 北市隆, 藤本鋭貴, 神原保, 黒部裕嗣, 北川哲也, 添木武, 飛梅威, 松浦朋美, 板東左知子, 佐田政隆 :
経皮的心肺補助装置(PCPS)装着下にカテーテルアブレーションを施行し，救命し得た心室頻拍1男児例,
第28回日本小児循環器学会近畿・中四国地方会, 2014年3月. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性,
第248回徳島医学会学術集会, 2014年2月. 松本和久, 高島啓, 山口浩司, 若槻哲三, 西條良仁, 高木恵理, 原知也, 齋藤友子, 小笠原梢, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 木村恵理子, 飛梅威, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置7年後に初めて造影剤ステント周囲滲み出し像を認めた一例,
第248回徳島医学会学術集会, 2014年2月. 八木秀介, 粟飯原賢一, 赤池雅史, 松本幸子, 福田大受, 松浦朋美, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 松本俊夫, 佐田政隆 :
DPP-4阻害薬の血糖降下作用に対する有効性予測因子,
第248回徳島医学会学術集会, 2014年2月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 佐田政隆, 阪田美穂, 早渕康信, 香美祥二, 井上美紀, 森一博, 木下学 :
薬剤抵抗性の特発性心室頻拍に対しPCPS下にカテーテルアブレーション治療を施行し，社会復帰に成功した一例,
第248回徳島医学会学術集会, 2014年2月. 坂東左知子, 添木武, 飛梅威, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 坂東正章, 佐田政隆 :
Aorta-mitral continuityが起源の心房頻拍の一例,
第103回日本循環器学会四国地方会, 2013年12月. 發知淳子, 山田博胤, 原知也, 太田理絵, 高島啓, 坂東美佳, 小笠原梢, 坂東左知子, 松浦朋美, 伊勢孝之, 木村恵理子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷の効果があった薬剤抵抗性起立性低血圧の2症例,
第103回日本循環器学会四国地方会, 2013年12月. 高島啓, 八木秀介, 高木恵理, 木下肇, 神原保, 原知也, 太田理絵, 坂東美佳, 坂東左知子, 伊勢孝之, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 木村建彦, 北川哲也, 佐田政隆 :
冠静脈洞に疣贅が認められた冠動静脈瘻を合併した感染性心内膜炎の一例,
第103回日本循環器学会四国地方会, 2013年12月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 島袋充生, 西條良仁, 高木恵理, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心身症として見過ごされてきた体位性起立頻脈症候群を的確に診断・治療し得た1例,
第103回日本循環器学会四国地方会, 2013年12月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 原知也, 小笠原梢, 齋藤友子, 高島啓, 坂東美佳, 發知淳子, 木村恵理子, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
上位共通路の存在が示唆され室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認めた1例,
第103回日本循環器学会四国地方会, 2013年12月. 坂東左知子, 飛梅威, 添木武, 松浦朋美, 西條良仁, 高木恵理, 原知也, 小笠原梢, 坂東美佳, 齋藤友子, 高島啓, 發知淳子, 木村恵理子, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
AMI急性期のVT/VF stormに対しtriggered PVC ablation を施行した一例,
第103回日本循環器学会四国地方会, 2013年12月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 西條良仁, 太田理絵, 原知也, 齋藤友子, 小笠原梢, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 木村恵理子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
ペースメーカー植込みの是非に検討を要した洞心不全症候群の一例,
第103回日本循環器学会四国地方会, 2013年12月. 石井亜由美, 西川幸治, 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 西條良仁, 高島啓, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 中山泰介, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 :
人工呼吸管理中の心不全症例に心臓リハビリテーションが有効に施行しえた症例,
第103回日本循環器学会四国地方会, 2013年12月. 伊勢孝之, 八木秀介, 岩瀬俊, 西條良仁, 高木恵理, 太田理絵, 門田宗之, 原知也, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
当院でのAdaptive-Servo Ventilationが有効であった拡張障害心不全の症例検討,
第103回日本循環器学会四国地方会, 2013年12月. 小笠原梢, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Fallot四徴症に対する根治術施行30年後に左心不全を合併した1例,
第109回日本内科学会四国地方会, 2013年12月. 玉置俊輔, 原知也, 伊勢孝之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠攣縮および器質的冠狭窄を合併したBuerger病の1例,
第109回日本内科学会四国地方会, 2013年12月. Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Shusuke Yagi, Takeshi Tobiume, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Progression of a Case of Myocardial Damage Caused by Beckers Muscular Dystrophy.,
第17回日本心不全学会学術集会, Nov. 2013. 坂東左知子, 添木武, 寒川賢治, 佐田政隆 :
自己免疫性心筋炎におけるヘルパーT細胞制御を介したグレリンの治療効果,
第17回日本心血管内分泌代謝学会学術総会, 2013年11月. 畠中貴代子, 山下修司, 橋村慧, 加藤瞭典, 田中保, 中山泰介, 木下肇, 原知也, 添木武, 佐田政隆, 北川哲也, 德村彰 :
心血管病変患者血漿でのリン脂質メディエーターLC-MS/MS 分析—バイオマーカーとしての有用性—,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, 2013年10月. 西條良仁, 山田博胤, 林修司, 西尾進, 發知淳子, 坂東美佳, 鳥居裕太, 天野里江, 添木武, 佐田政隆 :
僧房弁位人工弁機能不全の診断に3次元経食道心エコー検査が有用であった1例,
第23回日本超音波医学会四国地方会学術集会, 2013年10月. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
冠灌流域に合致しない心電図誘導にJ波を認めた急性冠症候群の一例,
第61回日本心臓病学会学術集会, 2013年9月. 太田理絵, 今田久美子, 八木秀介, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 上田由佳, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
経皮的腎動脈形成術により難治性心不全が改善した両側腎動脈狭窄症の1例,
第61回日本心臓病学会学術集会, 2013年9月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 原知也, 太田理絵, 坂東美佳, 高島啓, 坂東左知子, 松浦朋美, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全患者に対するトルバプタン投与における薬物血中濃度と利尿効果の検討,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 赤池雅史, 西尾進, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Intramural Hematoma症例のUlcer Like Projection形成と拡大における穿通枝の重要性,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 山田博胤, 坂東美佳, 西尾進, 山口浩司, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Becker型筋ジストロフィーによる心筋障害の経過を観察し得た1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 太田理絵, 山口浩司, 赤池雅史, 伊勢孝之, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性,
第61回日本心臓病学会学術集会, 2013年9月. 平田有紀奈, 山田博胤, 西尾進, 真鍋泰毅, 友藤達陽, 天野里江, 鳥居裕太, 山尾雅美, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症と各種脂肪厚との関連∼超音波検査を用いた検討∼,
第61回日本心臓病学会学術集会, 2013年9月. 山口浩司, 若槻哲三, 坂東美佳, 高島啓, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
Everolimus-eluting stent留置後における局所凝固反応とステント長の関連性,
第61回日本心臓病学会学術集会, 2013年9月. 安岡紗哉香, 山田博胤, 坂東美佳, 林修司, 西尾進, 天野里江, 平田有紀奈, 横倉航一, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
たこつぼ型心筋症の予後と回復過程に関する検討,
第61回日本心臓病学会学術集会, 2013年9月. 林修司, 山田博胤, 西尾進, 坂東美佳, 平田有紀奈, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈疾患におけるAugmentation indexの臨床的有用性についての検討,
第61回日本心臓病学会学術集会, 2013年9月. 若槻哲三, 山口浩司, 伊勢孝之, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
OCTにてmicrochannel構造を認める冠動脈プラークの局所炎症性の評価,
第61回日本心臓病学会学術集会, 2013年9月. 添木武, 坂東左知子, 松浦朋美, 高島啓, 坂東美佳, 發知淳子, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
心房細動におけるPentraxin3と心房リモデリングおよび予後との関係,
第61回日本心臓病学会学術集会, 2013年9月. 坂東左知子, 添木武, 植松悦子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 福田大受, 山田博胤, 若槻哲三, 島袋充生, 寒川賢治, 佐田政隆 :
自己免疫性心筋炎に対するグレリンの効果,
第61回日本心臓病学会学術集会, 2013年9月. 西尾進, 山田博胤, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, 真鍋泰毅, 友藤達陽, 坂東美佳, 林修司, 伊勢孝之, 山口浩司, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
各種血管機能検査指標における性差の影響,
第61回日本心臓病学会学術集会, 2013年9月. 今田久美子, 太田理絵, 八木秀介, 山口浩司, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山田博胤, 添木武, 佐田政隆, 春藤譲冶 :
経皮的腎動脈形成術により難治性心不全が改善したCardiac disturbance syndromeの1例,
第247回徳島医学会学術集会, 2013年8月. 生田奈央, 高島啓, 原知也, 伊勢孝之, 西條良仁, 高木恵理, 門田宗之, 太田理絵, 齋藤友子, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 島袋充生, 福田大受, 友竹正人 :
心身症として見過ごされていた体位性起立頻脈症候群を的確に診断・治療し得た一例,
第247回徳島医学会学術集会, 2013年8月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史 :
慢性心不全における新規利尿薬tolvaptanの効果予測因子,
第247回徳島医学会学術集会, 2013年8月. 石井亜由美, 西川幸治, 加藤真介, 伊勢孝之, 八木秀介, 岩瀬俊, 上田由佳, 門田宗之, 高島啓, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中川泰介, 北川哲也, 赤池雅史 :
人工呼吸管理中に心臓リハビリを有効に施行しえた開心術後の心不全症例,
第247回徳島医学会学術集会, 2013年8月. 西條良仁, 松浦朋美, 飛梅威, 添木武, 坂東左知子, 高木恵理, 太田理絵, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 三木延茂 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第247回徳島医学会学術集会, 2013年8月. 太田理絵, 八木秀介, 若槻哲三, 岩瀬俊, 西條良仁, 高木恵理, 門田宗之, 原知也, 齋藤友子, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 佐田政隆, 今田久美子, 髙尾正一郎 :
急性期の心電図でJ波を認めた急性心筋梗塞の一例,
第247回徳島医学会学術集会, 2013年8月. S Bando, Takeshi Soeki, T Matsuura, Yuka Ueda and Masataka Sata :
A Case of Atrioventricular Reentrant Tachycardia with Cycle Length Alternance.,
第28回日本不整脈学会学術大会, Jul. 2013. T Matsuura, Takeshi Soeki, S Bando, Yuka Ueda and Masataka Sata :
Effect of a Aliskiren on Atrial Endocardial Dysfunction in Rapidly Paced Rats.,
第28回日本不整脈学会学術大会, Jul. 2013. 八木秀介, 發知淳子, 山田博胤, 岩瀬俊, 伊勢孝之, 山口浩司, 添木武, 若槻哲三, 佐田政隆, 近藤剛史 :
高血圧・糖尿病・脂質異常症・脳心血管障害を合併した原発性副甲状腺機能亢進症の1例,
日本内科学会第108回四国地方会, 2013年6月. 坂東左知子, 山口浩司, 添木武, 太田理絵, 松浦朋美, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 四宮秀美 :
恒久ペースメーカ植込み後に発見された無症候性内頚静脈血栓の1例,
日本内科学会第108回四国地方会, 2013年6月. 太田理絵, 山口浩司, 發知淳子, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
41歳で初めて診断された肺動静脈瘻合併右肺動脈上行大動脈起始症の1例,
日本内科学会第108回四国地方会, 2013年6月. 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 友藤達陽, 坂東美佳, 林修司, 添木武, 佐田政隆 :
イルベサルタンは腎末梢血管抵抗を改善する ∼腎血管エコー検査を用いた検討∼,
第86回日本超音波医学会学術集会, 2013年5月. 發知淳子, 山田博胤, 西尾進, 平田有紀奈, 坂東美佳, 林修司, 冨田紀子, 添木武, 佐田政隆 :
膠原病関連運動誘発性肺高血圧における右室機能の評価,
第86回日本超音波医学会学術集会, 2013年5月. 友藤達陽, 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 平田有紀奈, 添木武, 添木武, 佐田政隆 :
心エコー法を用いた平均右房圧推定法の検証,
第86回日本超音波医学会学術集会, 2013年5月. 坂東美佳, 山田博胤, 西尾進, 平田有紀奈, 林修司, 發知淳子, 冨田紀子, 松浦朋美, 添木武, 佐田政隆 :
左房還流型左上大静脈遺残を伴うunroofed coronary sinusの1例,
第86回日本超音波医学会学術集会, 2013年5月. 林修司, 山田博胤, 發知淳子, 坂東美佳, 西尾進, 山尾雅美, 鳥居祐太, 平田有紀奈, 添木武, 佐田政隆 :
僧帽弁輸運動速波形と推定中心血圧を用いた左室-動脈連関の臨床的評価,
第86回日本超音波医学会学術集会, 2013年5月. 平田有紀奈, 西尾進, 友藤達陽, 坂東美佳, 林修司, 發知淳子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
超音波検査で計側した各種脂肪組織厚と冠動脈硬化症との関連,
第86回日本超音波医学会学術集会, 2013年5月. 平田有紀奈, 西尾進, 山田博胤, 發知淳子, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
冠動脈狭窄と関連する脂肪組織はどれか?∼超音波検査を用いた検討∼,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 西尾進, 山田博胤, 發知淳子, 平田有紀奈, 坂東美佳, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高血圧患者の腎末梢血管抵抗に対するイルベサルタンの効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 原知也, 門田宗之, 川端豊, 太田理絵, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 上田由佳, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
スピロノラクトンを中心とした薬物療法で30年間経過を観察しえたが，病勢制御困難となり手術療法を要したアルドステロン産生腺腫の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
治療方針に苦慮したDIC・多臓器不全合併コレステロール血晶塞栓症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 太田理絵, 山口浩司, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 坂東正章, 佐田政隆 :
治療方法選択に難渋した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東美佳, 山田博胤, 仁木敏之, 山口浩司, 發知淳子, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコードプラ検査と心臓カテーテル検査で圧較差に乖離を認めた大動脈弁狭窄症の2例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 羽星辰哉, 門田宗之, 發知淳子, 竹谷善雄, 神原保, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 北川哲也, 佐田政隆 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 小笠原梢, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
トルバプタンが効果を示したEisenmenger症候群に伴う高度右心不全の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高木恵理, 太田理絵, 仁木敏之, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 伊勢孝之, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
妊娠中に静脈血栓症を発症し診断されたATⅢ欠損症合併妊娠の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 山中森晶, 坂東左知子, 山口浩司, 西尾進, 太田理絵, 添木武, 松浦朋美, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 四宮秀美, 佐田政隆 :
永久ペースメーカー植え込み後に偶発的に見つかった内頸静脈血栓の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 高島啓, 島袋充生, 田端実, 植田初江, 植松悦子, 太田理絵, 門田宗之, 川端豊, 原知也, 坂東美佳, 坂東左知子, 松浦朋美, 仁木敏之, 伊勢孝之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 福田大受, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 高梨秀一郎, 佐田政隆 :
冠動脈内ステント内再狭窄4症例の病理組織学的検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 岩瀬俊, 山田博胤, 川端豊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 八木秀介, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心病変の経過を観察し得たBecker型筋ジストロフィーによる心不全の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 坂東左知子, 添木武, 門田宗之, 川端豊, 原知也, 高島啓, 坂東美佳, 松浦朋美, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 若槻哲三, 石本武男, 佐田政隆 :
AVN dual pathwayにより頻拍周期が一心拍ごとに変化下Orthodromic AVRTの一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 松浦朋美, 添木武, 伊勢孝之, 仁木敏之, 發知淳子, 上田由佳, 冨田紀子, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
通電により電動特性が変化した副伝導路の一例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 發知淳子, 山田博胤, 西尾進, 坂東美佳, 林修司, 冨田紀子, 太田理絵, 門田宗之, 川端豊, 原知也, 高島啓, 坂東左知子, 松浦朋美, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
運動誘発性肺高血圧を有する膠原病例における右室機能の検討,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性心不全におけるAdaptive-Servo Ventilationの血行動態に対する効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 西尾進, 添木武, 坂東左知子, 松浦朋美, 平田有紀奈, 坂東美佳, 發知淳子, 林修司, 冨田紀子, 山田博胤, 佐田政隆 :
心房細動例の左心耳局所炎症と左心耳経食道心エコー図指標との関連,
第24回日本心エコー図学会学術集会, 2013年4月. T Matsuura, Takeshi Soeki, S Bando, T Hara, M Kadota, Y Kawabata, Mika Bando, J Hotchi, N Tomita, Yuka Ueda, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
A Renin Inhibitor Prevents Atrial Endocardial Dysfunction in Rapidly Paced Rats with Streptozotocin-induced Diabetes.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada and Masataka Sata :
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed by Integrated Backscatter Intravascular Ultrasound.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Takashi Iwase, Shoichiro Takao, M Kadota, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Shusuke Yagi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masafumi Harada and Masataka Sata :
Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis.,
第77回日本循環器学会学術集会, Mar. 2013. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, R Ota, M Kadota, Y Kawabata, T Hara, Mika Bando, S Bando, T Matsuura, Takayuki Ise, J Hotchi, Yuka Ueda, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Differential Responses of Local Coagulation after Implantation of Everolimus-Eluting Stent Compared with Early-Generation Drug-Eluting Stents.,
第77回日本循環器学会学術集会, Mar. 2013. Shusuke Yagi, Takayuki Ise, Hirotsugu Yamada, S Nishio, Yuka Ueda, Takashi Iwase, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia.,
第77回日本循環器学会学術集会, Mar. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance.,
第77回日本循環器学会学術集会, Mar. 2013. M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Toshiyuki Niki, Tetsuzo Wakatsuki, Mika Bando, Koji Yamaguchi, Yoshio Taketani, R Ota, Y Kawabata, M Kadota, T Hara, Mika Bando, Takayuki Ise, T Matsuura, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Effects of Additional Eicosapentaenoic Acid Therapy on Inflammatory Cytokines and Atherosclerotic Plaque Component Assessed by Integrated Backscatter Ultrasound Systems.,
第77回日本循環器学会学術集会, Mar. 2013. Daiju Fukuda, Michio Shimabukuro, Shusuke Yagi, Takeshi Soeki and Masataka Sata :
Genetic Ablation of TLR9 Improves Insulin Resistance through the Reduction of Hepatic SREBP-1c Expression.,
第77回日本循環器学会学術集会, Mar. 2013. Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Daiju Fukuda, Takeshi Soeki, H Sato, E Uematsu, Sachiko Matsumoto, Hiroshi Sakaue, Hirofumi Izaki, Hiro-omi Kanayama and Masataka Sata :
MicroRNA-100 Regulates Adipocytokine Expression in Subcutaneous and Visceral Adipose Tissue: An Observation from Human Biopsy Study.,
第77回日本循環器学会学術集会, Mar. 2013. 添木武, S Bando, T Matsuura, T Hara, R Ota, Y Kawabata, 坂東美佳, J Hotchi, N Tomita, 上田由佳, 仁木敏之, 伊勢孝之, 山口浩司, 八木秀介, 福田大受, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation.,
第77回日本循環器学会学術集会, 2013年3月. Mika Bando, Hirotsugu Yamada, S Nishio, N Tomita, J Hotchi, S Hayashi, K Ogasawara, A Takashima, S Bando, Takayuki Ise, Toshiyuki Niki, T Matsuura, Yuka Ueda, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Eicosapentaenoic Acid on the Stabilization of Vulnerability in Carotid Artery Plaque: Evaluation Using iPlaque® Software.,
第77回日本循環器学会学術集会, Mar. 2013. S Bando, Daiju Fukuda, Takeshi Soeki, E Uematsu, H Sato, A Takashima, Mika Bando, T Matsuura, Toshiyuki Niki, Takayuki Ise, J Hotchi, Yuka Ueda, N Tomita, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome Activation in Adipose Tissue and Atherosclerosis.,
第77回日本循環器学会学術集会, Mar. 2013. Michio Shimabukuro, Y Hirata, M Tabata, M Dagvasumberel, Daiju Fukuda, Hirotsugu Kurobe, Takeshi Soeki, S Takanashi and Masataka Sata :
Epicardial Adipose Tissue Volume as a Novel Determinant of Human Coronary Atherosclerosis: Role of Adipocytokine Imbalance.,
第77回日本循環器学会学術集会, Mar. 2013. Takeshi Soeki, Koji Yamaguchi, Toshiyuki Niki, R Ota, T Hara, M Kadota, Mika Bando, S Bando, T Matsuura, J Hotchi, N Tomita, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Cardiospecific microRNA Plasma Levels are Associated With Coronary Plaque Vulnerability.,
第77回日本循環器学会学術集会, Mar. 2013. E Takagi, R Ota, 仁木敏之, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中山聡一朗, 前田和寿, 苛原稔 :
妊娠を契機にATⅢ欠損症と診断され，血栓管理の後に出産に至った一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. T Haboshi, M Kadota, J Hotchi, 竹谷善雄, T Matsuura, 伊勢孝之, 仁木敏之, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 木下肇, 神原保, 北川哲也, 古本博孝, 髙橋久弥 :
プロテインC欠損に心房細動および低左心機能を合併した左室・右房内血栓の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, M Takeuchi :
再熱と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. K Ota, 仁木敏之, R Ota, Y Kawabata, M Kadota, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, J Shunto :
偶発的に発見された末梢動脈閉塞の二例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. M Koda, 佐田政隆, 伊勢孝之, Y Kawabata, 岩瀬俊, M Kadota, T Hara, R Ota, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, S Okazaki, 林友鴻, T Hasegawa :
難治性の閉塞性肥大型心筋症に対して経皮的中隔心筋焼灼術が著効した1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. R Ota, 山口浩司, M Kadota, Y Kawabata, T Hara, A Takashima, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, 仁木敏之, J Hotchi, 上田由佳, 八木秀介, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 原田雅史, M Bando :
41歳まで無症状で経過した肺動静脈瘻合併右肺動脈上行大動脈起始症の一例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. 坂東美佳, 山田博胤, S Nishio, R Tamai, Y Hirata, N Tomita, J Hotchi, S Hayashi, M Nakagawa, D Hirota, A Takashima, 伊勢孝之, 仁木敏之, 山口浩司, 福田大受, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
イコサペント酸エチルは頸動脈プラークの安定化に寄与する:iPlaque®を用いた検討,
第101回日本循環器学会四国地方会, 2012年12月. 上田由佳, 伊勢孝之, 岩瀬俊, K Maeda, K Nishikawa, M Kadota, T Hara, Y Kawabata, R Ota, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
心臓リハビリテーションにおける禁煙継続効果の検討,
第101回日本循環器学会四国地方会, 2012年12月. Y Kawabata, 伊勢孝之, T Matsuura, S Bando, 岩瀬俊, K Ogasawara, 坂東美佳, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度肥満を伴った拡張型心筋症の1例,
第101回日本循環器学会四国地方会, 2012年12月. R Ota, 仁木敏之, 竹谷善雄, M Kadota, Y Kawabata, T Hara, 坂東美佳, S Bando, T Matsuura, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
カテーテル的血栓吸引・血栓溶解療法が奏功し，心肺停止状態から救命できた院内発症急性肺血栓塞栓症の一例,
第101回日本循環器学会四国地方会, 2012年12月. M Nakagawa, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, 坂東美佳, R Tamai, Y Hirata, D Hirota, S Yasuoka, K Yokokura, 仁木敏之, 伊勢孝之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心房細動例における拡張中期僧帽弁口血流速波高は左室充満圧を反映する,
第101回日本循環器学会四国地方会, 2012年12月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
再燃と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第101回日本循環器学会四国地方会, 2012年12月. N Kobayashi, T Hara, 山口浩司, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, M Bando, 佐田政隆 :
多彩な血圧変動素因により顕著な夜間血圧を認めた一例,
第101回日本循環器学会四国地方会, 2012年12月. S Yasuoka, 山田博胤, K Yokokura, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
当院におけるたこつぼ型心筋症の臨床的特徴,
第101回日本循環器学会四国地方会, 2012年12月. K Yokokura, 山田博胤, S Yasuoka, Y Hirata, D Hirota, R Tamai, M Nakagawa, S Nishio, 坂東美佳, J Hotchi, S Hayashi, N Tomita, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
心エコー法を用いた平均右房圧推定法の検証,
第101回日本循環器学会四国地方会, 2012年12月. T Hara, 山口浩司, 岩瀬俊, M Kadota, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, S Orino, 佐田政隆 :
Churg-Strauss症候群に合併した好酸球性心筋炎の一例,
第101回日本循環器学会四国地方会, 2012年12月. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, Y Hirata, D Hirota, M Nakagawa, S Hayashi, N Tomita, J Hotchi, Toshiyuki Niki, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Nagahiro and Masataka Sata :
Effect of EPA of Carotid Artery Plaque Assessed by Integrated Backscatter Mapping : Development of imaging analytical software.,
第20回日本血管生物医学会学術集会, Dec. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, H Oezuka, R Ota, Y Kawabata, T Hara, M Kadota, K Ogasawara, S Bando, T Matuura, J Hotchi, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Telmisartan reduces local inflammatory response and coronary plaque vulnerability assessed by integrated backscatter intravascular ultrasound in hypertensive patients.,
第20回日本血管生物医学会学術集会, Dec. 2012. S Bando, Daiju Fukuda, Takeshi Soeki, E Uematsu, H Sato, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 inflammasome and atherosclerosis.,
第20回日本血管生物医学会学術集会, Dec. 2012. Y Yokota, S Bando, 添木武, M Kadota, T Matsuura, 山田博胤, 若槻哲三, 佐田政隆, H Yoshida, T Ishimoto :
AVN dual pathwayにより頻拍周期が1心拍ごとに変化したOrthodromic AVRTの1例,
第107回日本内科学会四国地方会, 2012年12月. M Miyauchi, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心臓粗動を契機として右心不全を発症し，左房還流型PLSVCとunroofed CSの合併が判明した1例,
第107回日本内科学会四国地方会, 2012年12月. M Kadota, Takayuki Ise, Takashi Iwase, Masashi Akaike, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki and Masataka Sata :
Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. J Hotchi, 山田博胤, 坂東美佳, S Hayashi, N Tomita, S Nishio, Y Hirata, D Hirota, 添木武, 佐田政隆 :
大動脈弁穿孔を伴った感染性心内膜炎の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. M Nakagawa, S Nishio, R Tamai, D Hirota, Y Hirata, 添木武, 山田博胤, 佐田政隆 :
診断と治療効果の判定に超音波検査が有用であった上肢バージャー病の1例,
第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, 2012年10月. 仁木敏之, 若槻哲三, 坂東美佳, 西尾進, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
スタチンへのEPA製剤追加による動脈硬化病変の組織性状変化に関する検討,
第60回日本心臓病学会学術集会, 2012年9月. Y Hirata, T Hara, 山田博胤, S Nishio, D Hirota, R Tamai, M Nakagawa, 坂東美佳, J Hotchi, N Tomita, S Hayashi, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心膜内膿瘍を合併した収縮性心膜炎の一例,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, 伊勢孝之, 岩瀬俊, T Hara, M Kadota, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第60回日本心臓病学会学術集会, 2012年9月. J Hotchi, 山田博胤, S Nishio, 坂東美佳, S Hayashi, N Tomita, Y Hirata, D Hirota, R Tamai, M Nakagawa, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
安静時に肺高血圧を呈さない膠原病例における心エコー・ドプラ法を用いた右室機能不全の評価,
第60回日本心臓病学会学術集会, 2012年9月. 山口浩司, 若槻哲三, 仁木敏之, 竹谷善雄, S Bando, 伊勢孝之, 岩瀬俊, 山田博胤, 添木武, 佐田政隆 :
シロリムス溶出ステント留置後における局所血管反応の検討-局所バイオマーカーとperi-contrast stainingの観点から-,
第60回日本心臓病学会学術集会, 2012年9月. S Hayashi, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁口血流速波系が偽正常化パターンを示す左室駆出率が保持された心不全(HFPEF)と左房機能不全の鑑別,
第60回日本心臓病学会学術集会, 2012年9月. 伊勢孝之, 岩瀬俊, K Nanjo, 髙尾正一郎, R Ota, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
心臓MRIを用いた左室肥大患者における右室壁厚の検討,
第60回日本心臓病学会学術集会, 2012年9月. 添木武, 山口浩司, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, T Matsuura, N Tomita, 上田由佳, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
血中micro RNAは冠動脈不安定プラークのバイオマーカーになりえるか?,
第60回日本心臓病学会学術集会, 2012年9月. S Bando, 添木武, T Matsuura, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 島袋充生, 佐田政隆 :
NLRPインフラマソームと冠動脈硬化の関連について,
第60回日本心臓病学会学術集会, 2012年9月. H Sato, 島袋充生, Y Hirata, M Tabata, M Dagvasumberel, S Bando, 黒部裕嗣, 福田大受, 添木武, S Takanashi, 北川哲也, 中屋豊, 佐田政隆 :
心臓周囲脂肪酸NLRP3インフラマゾームのヒト冠動脈硬化症における役割,
第60回日本心臓病学会学術集会, 2012年9月. 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, R Tamai, M Nakagawa, D Hirota, Y Hirata, S Hayashi, K Ogasawara, 仁木敏之, 山口浩司, 添木武, 若槻哲三, 佐田政隆 :
重症大動脈弁狭窄症を呈した成人大動脈一尖弁の2例,
第60回日本心臓病学会学術集会, 2012年9月. 若槻哲三, 仁木敏之, 山口浩司, 伊勢孝之, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 佐田政隆 :
OCTにてneovascularizationを認めた冠動脈プラークのIB-IVUSによる組織性状の評価,
第60回日本心臓病学会学術集会, 2012年9月. S Nishio, 山田博胤, M Sato, H Hiraoka, Y Hirata, D Hirota, 坂東美佳, S Hayashi, J Hotchi, N Tomita, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
糖尿病において左房容積係数と最も相関する非侵襲的血管検査指標は何か:左房-左室-血管連関についての検討,
第60回日本心臓病学会学術集会, 2012年9月. 仁木敏之, 若槻哲三, 坂東美佳, S Nishio, K Ogasawara, S Bando, 伊勢孝之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, H Yamada, 添木武, 佐田政隆 :
スタチンへのEPA製剤追加による動脈硬化病変の組織性状変化に関する検討,
第60回日本心臓病学会学術集会, 2012年9月. Y Yokota, M Kadota, 伊勢孝之, 岩瀬俊, T Hara, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 江川麻理子, 三田村佳典 :
眼病変の経過中に心室中隔の肥厚および完全房室ブロックで発症した心サルコイドーシスの一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kawano, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, T Yamamoto, K Kawano, 角谷明佳, K Seto, 金山博臣 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. K Matsumoto, 仁木敏之, K Ogasawara, R Ota, M Kadota, Y Kawabata, T Hara, 伊勢孝之, T Matsuura, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, Y Sawa :
プロテインC活性低下を背景とし，オートマチック車への変更を契機に肺血栓塞栓症を発症したタクシー運転手の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. N Kobayashi, T Hara, 山口浩司, M Kadota, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, J Hotchi, N Tomita, 伊勢孝之, 仁木敏之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, M Bando :
著名な自立神経障害を背景とした治療抵抗性夜間高血圧症の一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. 上田由佳, 岩瀬俊, 伊勢孝之, K Maeda, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
喫煙継続者における心臓リハビリテーションの効果の検討,
第18回心臓リハビリテーション学会, 2012年7月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
患者の気持ちを汲んだ患者教育の実際,
第18回心臓リハビリテーション学会, 2012年7月. A Takashima, 伊勢孝之, 上田由佳, K Maeda, K Nishikawa, K Ogasawara, 坂東美佳, N Tomita, 仁木敏之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
第18回心臓リハビリテーション学会, 2012年7月. S Bando, 添木武, 伊勢孝之, 岩瀬俊, 坂東美佳, K Ogasawara, J Hotchi, N Tomita, 仁木敏之, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 菅野幹雄, 神原保, 北川哲也, 佐田政隆 :
心房周囲炎症と心囊液貯留により収縮性心膜炎の病態を呈した一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. A Tachibana, 伊勢孝之, 添木武, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
CRT-Dが著効した重症拡張型心筋症の2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Nagasaka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
マルチモダリティを用いて鑑別し得た冠動脈病変合併たこつぼ型心筋症の1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, K Nanjo, 岩瀬俊, 髙尾正一郎, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
左室肥大患者における右室壁厚の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. J Hotchi, S Taoka, 坂東美佳, K Ogasawara, A Takashima, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 上田由佳, N Tomita, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, Y Saijo, 佐田政隆 :
緊密な病診連携と詳細な副腎静脈サンプリングが迅速な根治術につながった原発性アルドステロン症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, A Takashima, H Yamasaki, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Adaptive Servo-Ventilationが心不全治療に有効であった心アミロイドーシスの2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
チーム医療で取り組む重症心不全に対する心臓リハビリテーション,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Taoka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, K Ogasawara, 坂東美佳, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
テニスラケットによる打撲が誘引で深部静脈血栓・急性肺塞栓症を来した1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Ogasawara, 仁木敏之, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, N Tomita, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆 :
永久型下大静脈フィルター血栓閉塞に対し抗凝固療法を中心とした保存的加療が有効であった2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 坂東美佳, 山田博胤, K Ogasawara, 仁木敏之, N Tomita, J Hotchi, R Tamai, Y Hirata, D Hirota, S Nishio, S Bando, 伊勢孝之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, H Kawano, 西岡安彦 :
肺動脈血栓に対してフォンダパリヌクスが著効した静脈血栓塞栓症の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. R Tamai, 坂東美佳, 山田博胤, S Nishio, N Tomita, J Hotchi, S Hayashi, M Nakagawa, Y Hirata, D Hirota, K Ogasawara, H Yamasaki, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超音波後方散乱信号を用いたカラーマッピングシステムの脂質低下療法における臨床応用:case report,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. Y Oguro, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
マニュアル車からオートマチック車に変更後に左下肢深部静脈血栓症を生じたタクシー運転手の一例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 森住俊, J Hotchi, 山田博胤, 坂東美佳, H Yamasaki, K Ogasawara, K Takashima, S Bando, 伊勢孝之, 仁木敏之, 山口浩司, N Tomita, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
完全房室ブロックを合併して恒久的ペースメーカー植込みを必要としたたこつぼ型心筋症の一症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. N Kawano, 仁木敏之, K Ogasawara, 坂東美佳, S Bando, 伊勢孝之, J Hotchi, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, N Tomita, 山田博胤, 添木武, 若槻哲三, T Yamamoto, K Kawano, 角谷明佳, 佐田政隆 :
シスプラチン，エトポシド，ブレオマイシンの三剤化学療法併用中に急性心筋梗塞を発症した二例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, H Oezuka, K Ogasawara, 坂東美佳, S Bando, J Hotchi, 上田由佳, N Sakamoto, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 坂東美佳, 山田博胤, S Nishio, R Tamai, Y Hirata, D Hirota, J Hotchi, N Tomita, 添木武, 佐田政隆 :
超音波integrated backscatterカラーマッピング法による頸動脈プラークの組織性状診断,
日本超音波医学会第85回学術集会, 2012年5月. S Hayashi, M Sato, 山田博胤, N Tomita, J Hotchi, 坂東美佳, S Nishio, R Tamai, M Nakagawa, D Hirota, Y Hirata, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
僧帽弁輪運動速波形指標およびAugmentation Indenxの性差と相互連関についての検討,
第23回日本心エコー図学会学術集会, 2012年4月. N Tomita, 山田博胤, S Nishio, J Hotchi, S Hayashi, 坂東美佳, M Nakagawa, R Tamai, Y Hirata, D Hirota, Hiraoka H, M Sato, 竹谷善雄, 添木武, 佐田政隆 :
大動脈弁硬化における性差の検討,
第23回日本心エコー図学会学術集会, 2012年4月. Mika Bando, Hirotsugu Yamada, S Nishio, R Tamai, N Tomita, J Hotchi, S Hayashi, M Nakagawa, Y Hirata, D Hirota, Yoshio Taketani, Takeshi Soeki and Masataka Sata :
Effect of statin therapy on carotid artery plaque assesed by integrated backscatter color mapping.,
第23回日本心エコー図学会学術集会, Apr. 2012. Tomita Noriko, 山田博胤, 楠瀬賢也, Nishio Susumu, Hotchi Junko, Hayashi Shuji, 坂東美佳, Bando Sachiko, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第76回日本循環器学会学術集会, 2012年3月. Munkbaatar Dagvasumberel, 島袋充生, Nishiuchi Takeshi, Hirata Yoichiro, 添木武, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 八木秀介, Tomita Noriko, 山田博胤, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
Gender Disparities in Association of Epicardial Adipose Tissue Volume and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, 2012年3月. Bando Sachiko, Takeshi Soeki, Ogasawara Kozue, Takashima Akira, Mika Bando, Yamazaki Hiromu, Hotchi Junko, Tomita Noriko, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Relationship between NLRP3 Inflammasome and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, Mar. 2012. Hotchi Junko, Hirotsugu Yamada, Kenya Kusunose, Nishio Susumu, Mika Bando, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Irbesartan on Left Ventricular Myocardial Function in Patients with Hypertension: Assessment by Two-dimensional Speckle Tracking Echocardiography.,
第76回日本循環器学会学術集会, Mar. 2012. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Bando Sachiko, Hotchi Junko, Tomita Noriko, Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
Angiographic Peri-stent Contrast Staining Leading to Local Persistent Hypercoagulability up to Five Years after Sirolimus-eluting Stent Implantation:Comparison with Bare-Metal Stent.,
第76回日本循環器学会学術集会, Mar. 2012. Kimura Sahika, 上田由佳, 伊勢孝之, 岩瀬俊, Takashima Akira, Yamazaki Hiromu, Ogasawara Kozue, Bando Sachiko, Hayashi Shuji, Takeuchi Hidekazu, 仁木敏之, 楠瀬賢也, 山口浩司, Tomita Noriko, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Cardiac Rehabilitation decreases Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
第76回日本循環器学会学術集会, 2012年3月. Takashima Akira, Takayuki Ise, Takashi Iwase, Yuka Ueda, Masashi Akaike, Yamazaki Hiromu, Mika Bando, Ogasawara Kozue, Bando Sachiko, Tomita Noriko, Takeuchi Hidekazu, Toshiyuki Niki, Hotchi Junko, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Cardiac Rehabilitation on Level of Oxidized LDL.,
第76回日本循環器学会学術集会, Mar. 2012. Hirotsugu Yamada, Tomita Noriko, Hayashi Shuji, Hotchi Junko, Nishio Susumu, Tamai Rina, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Prognostic Value of Preload Stress Echocardiographyin Patients with Mild Heart Failure.,
第76回日本循環器学会学術集会, Mar. 2012. 添木武, 仁木敏之, 山口浩司, 坂東左知子, 上田由佳, 冨田紀子, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2012年3月. 山田博胤, 西尾進, 坂東美佳, 發知淳子, 林修司, 冨田紀子, 伊勢孝之, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
Carotid Ultrasound Imaging to Evaluate Atherosclerotic Diseases.,
第76回日本循環器学会学術集会，KSC-JCS Joint Symposium-2, 2012年3月. 立花綾香, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 廣野明 :
CRT-Dが著効した重症慢性心不全の1例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 田岡志保, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 井上洋行 :
テニスラケットによる外傷が誘因で深部静脈血栓・急性肺塞栓症を来した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 森住俊, 發知淳子, 山田博胤, 山崎宙, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 仁木敏之, 山口浩司, 冨田紀子, 上田由佳, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 久保克之, 佐々木克哉, 富田芳雄 :
たこつぼ型心筋症に完全房室ブロックを合併した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの臨床応用,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 小笠原梢, 坂東美佳, 坂東左知子, 發知淳子, 上田由佳, 冨田紀子, 竹内秀和, 伊勢孝之, 岩瀬俊, 山田博胤, 佐田政隆, 麻植塚浩康 :
テルミサルタンの冠動脈プラークに対する抗動脈硬化作用の検討,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 仁木敏之, 小笠原梢, 坂東美佳, 坂東左知子, 竹内秀和, 伊勢孝之, 發知淳子, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 太田理絵, 若槻哲三, 岩瀬俊, 髙尾正一郎, 山田博胤, 赤池雅史, 坂東左知子, 仁木敏之, 能勢隼人, 冨田紀子, 山口浩司, 竹谷善雄, 添木武, 西岡安彦, 原田雅史, 佐田政隆 :
肺，皮膚病変診断4年後に心病変が顕在化したサルコイドーシスの1例,
第22回日本心血管画像動態学会, 2012年1月. 仁木敏之, 若槻哲三, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 小笠原梢, 坂東美佳, 坂東左知子, 伊勢孝之, 冨田紀子, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on 効果の検討-IB-IVUSおよびIB-頸動脈エコーの観点から-,
第22回日本心血管画像動態学会, 2012年1月. 前田香代子, 上田由佳, 伊勢孝之, 岩瀬俊, 西川幸治, 高島啓, 小笠原梢, 山崎宙, 坂東左知子, 仁木敏之, 發知淳子, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げの問題点,
第99回日本循環器学会四国地方会, 2011年12月. 坂東美佳, 林修司, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
平滑筋肉腫の心筋内転移の診断，経過観察に経胸壁心エコー法が有用であった一例,
第99回日本循環器学会四国地方会, 2011年12月. 高島啓, 山口浩司, 原知也, 山崎宙, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 仁木敏之, 伊勢孝之, 上田由佳, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 花岡潤, 島田光生, 佐田政隆 :
真性多血症患者に発症した心原生脾梗塞の1例,
第99回日本循環器学会四国地方会, 2011年12月. 田根なつ紀, 山口浩司, 竹谷善雄, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 伊勢孝之, 發知淳子, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症下肢虚血病変に対して経皮的下肢動脈形成術が奏功し，予定されていた下肢切断手術を回避できた一症例,
第99回日本循環器学会四国地方会, 2011年12月. 高橋直希, 仁木敏之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 發知淳子, 山口浩司, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中瀧恵実子, 西村匡司, 上山祐二 :
低体温療法が著効し社会復帰をなし得たBrugada症候群の一例,
第99回日本循環器学会四国地方会, 2011年12月. 藤岡啓介, 山崎宙, 伊勢孝之, 楠瀬賢也, 木村白陽花, 高島啓, 小笠原梢, 坂東左知子, 發知淳子, 冨田紀子, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
ULPの発生から拡大，消失までを経時的に観察し得たacute aortic syndromeの一例,
第99回日本循環器学会四国地方会, 2011年12月. 坂東左知子, 山田博胤, 添木武, 木内誠, 北畑洋, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 佐田政隆 :
全身麻酔により顕在性Brugada型心電図の1例,
第105回日本内科学会四国地方会, 2011年11月. 坂東左知子, 添木武, 伊勢孝之, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 木村建彦, 西内健, 佐田政隆 :
CRT-Dによって僧帽弁閉鎖不全症が劇的に改善した突発性拡張型心筋症の1例,
第105回日本内科学会四国地方会, 2011年11月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 伊勢孝之, 小笠原梢, 山崎宙, 髙島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
心臓MRIによるサルコイドーシス心病変検出の有用性,
第31回日本サルコイドーシス/肉芽腫性疾患学会総会, 2011年10月. 木谷光宏, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 赤池雅史, 山本浩史, 折野俊介, 角谷昭佳, 坂東重信, 佐田政隆 :
高血圧患者におけるシルニジピンの酸化ストレスに対する作用,
第34回日本高血圧学会総会, 2011年10月. 林修司, 山田博胤, 西尾進, 玉井利奈, 中川摩耶, 弘田大智, 平田有紀奈, 岩瀬俊, 添木武, 佐田政隆 :
多発性肺平衡筋肉腫の心筋内転移の診断，経過観察に経胸壁心エコーが有用であった一例,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 發知淳子, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 弘田大智, 玉井利奈, 添木武, 佐田政隆 :
保存的加療により潰瘍様突出像が消退した大動脈壁内血腫の一例,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 玉井利奈, 山田博胤, 西尾進, 冨田紀子, 林修司, 發知淳子, 平田有紀奈, 弘田大智, 添木武, 佐田政隆 :
左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴,
第21回日本超音波医学会四国地方学術集会, 2011年10月. 冨田紀子, 山田博胤, 西尾進, 林修司, 發知淳子, 中川摩耶, 平田有紀奈, 弘田大智, 添木武, 佐田政隆 :
S字状中隔心の心エコー・ドプラ所見についての検討,
第21回日本超音波医学会四国地方会学術集会, 2011年10月. Takayuki Ise, Takashi Iwase, Kumiko Kagawa, Toshiyuki Niki, Kenya Kusunose, 冨田紀子, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masahiro Abe, Masashi Akaike and Masataka Sata :
Successful Autologous Peripheral Blood Stem Cell Transplantation for Primary Cardiac Amyloidosis Patients with Heart Failure : three cases report.,
第15回日本心不全学会学術集会, Oct. 2011. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 上田由佳, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
心房細動における僧帽弁口血流速拡張早期波の心拍変動性の臨床的意義,
第59回日本心臓病学会学術集会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
三尖弁輪運動速波形による肥大型心筋症と高血圧性心疾患の鑑別,
第59回日本心臓病学会学術集会, 2011年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 久岡白陽花, 伊勢孝之, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
サルコイドーシス心病変検出における心臓MRI検査の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 冨田紀子, 楠瀬賢也, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンによる自律神経およびConnexin43発現調節を介した抗不整脈作用の検討,
第59回日本心臓病学会学術集会, 2011年9月. 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 清水拓, 林修司, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
膠原病における潜在性肺動脈性高血圧症の検出:運動負荷心エコー法の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査法についての検討,
第59回日本心臓病学会学術集会, 2011年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 冨田紀子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴:HFPEFとHFREFの差異,
第59回日本心臓病学会学術集会, 2011年9月. 山口浩司, 若槻哲三, 添木武, 仁木敏之, 竹谷善雄, 麻植塚浩康, 坂東左知子, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 岩瀬俊, 山田博胤, 佐田政隆 :
冠動脈プラークに対するテルミサルタンの多面的効果の検討-Integrated backscatter IVUS観察と炎症性サイトカインによる観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 添木武, 坂東左知子, 仁木敏之, 久岡白陽花, 竹内秀和, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動における局所炎症反応に関する検討,
第59回日本心臓病学会学術集会, 2011年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 麻植塚浩康, 西尾進, 坂東左知子, 冨田紀子, 竹内秀和, 山田博胤, 添木武, 佐田政隆 :
冠動脈プラークに対するスタチンへのEPA製剤add on効果の検討 -Integrated backscatter IVUSおよび局所Biomaker観察の観点から-,
第59回日本心臓病学会学術集会, 2011年9月. 高木恵理, 高島啓, 山口浩司, 竹谷善雄, 坂東左知子, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 森本篤志, 橋本一郎, 中西秀樹, 和田美智子, 石本武男, 田蒔正治 :
重症下肢虚血病変に対して経皮的下肢動脈血管形成術が奏功し，予定されていた下肢切手術を回避できた一症例,
第243回徳島医学会学術集会, 2011年7月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第243回徳島医学会学術集会, 2011年7月. 高島啓, 添木武, 山口浩司, 竹谷善雄, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの増悪と改善が観察できた拡張相肥大型心筋症の一例,
第243回徳島医学会学術集会, 2011年7月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
当院心臓リハビリテーション参加者の運動能力について,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げに携わって,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
TE-e'は左室拡張末期圧を反映する―下肢腸圧および硝酸薬負荷を用いた検討―,
第84回日本超音波医学会学術集会, 2011年5月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 西尾進, 玉井利奈, 岩瀬俊, 添木武, 佐田政隆 :
体位変換により右室内圧較差が変化をきたす右室二腔症の一例,
第84回日本超音波医学会学術集会, 2011年5月. 西尾進, 山田博胤, 楠瀬賢也, 玉井利奈, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査指標は何か?,
第84回日本超音波医学会学術集会, 2011年5月. 竹内秀和, Tetsuzo Wakatsuki, 阪本紀子, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata :
BNP relates to FT3 negatively in cardiac patients with normal FT3, which might be mediated by HDAC3.,
第98回日本循環器学会中国・四国合同地方会, May 2011. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. Munkhbaatar Dagvasumberel, Junji Ueno, Shoichiro Takao, 西内健, 平田陽一郎, 坂東左知子, 久岡白陽花, 林修司, 冨田紀子, 竹内秀和, Yuka Ueda, Toshiyuki Niki, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Tetsuya Kitagawa and Masataka Sata :
Increased epicardial adipose tissue and coronary atherosclerosis.,
第98回日本循環器学会中国・四国合同地方会, May 2011. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆, 西尾進, 玉井利奈, 三木淳子 :
ストロークケアユニット(SCU)に救急搬送された心原性脳塞栓症例の特徴,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 玉井利奈, 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
下肢静脈エコー検査におけるD-dimer値の意義,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西尾進, 山田博胤, 玉井利奈, 平田陽一郎, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
頸動脈エコーによるプラークの超音波性状カラーイメージの試み,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
通院型心臓リハビリテーションの継続における開始3カ月目の重要性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
心臓リハビリによる運動能力改善を阻害する因子の検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 太田理絵, 岩瀬俊, 久岡白陽花, 山田博胤, 西岡安彦, 髙尾正一郎, 坂東左知子, 能勢隼人, 楠瀬賢也, 仁木敏之, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
心室固有調律が心病変診断のきっかけとなったサルコイドーシスの1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 原知也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスにおける左室形態異常の多様性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 小笠原梢, 仁木敏之, 添木武, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 佐田政隆 :
様々な要因によりtorsade de pointesを来した一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排出量に及ぼす通院心臓リハビリテーションの効果,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 添木武, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの憎悪と改善が観察できた拡張肥大型心筋症の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 冨田紀子, 山田博胤, 西尾進, 楠瀬賢也, 林修司, 玉井利奈, 遠藤桂輔, 平岡葉月, 佐藤光代, 坂東左知子, 久岡白陽花, 竹内秀和, 上田由佳, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
超高齢者における大動脈弁硬化の進行に関与する因子についての検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 玉井利奈, 三木淳子, 坂東左知子, 久岡白陽花, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
S字状中隔によるdynamic obstructionが胸痛の原因と考えられた高齢者の一例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 坂東左知子, 添木武, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
房室結節三重伝道路の存在が示唆された房室結節リエントリー性頻拍の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 高島啓, 山口浩司, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 吉田守美子, 松本俊夫, 佐田政隆 :
甲状腺機能亢進症と腰痛が発症の誘因と考えられた難治性冠攣縮性狭心症の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 外磯千智, 岩瀬俊, 楠瀬賢也, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史 :
心臓MRI検査で左室に広範なガドリニウム異常集積を認めたNoonan syndromeの1例,
第104回日本内科学会四国地方会, 2011年5月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
高齢者における大動脈弁硬化の進行に関与する因子についての検討,
第22回日本心エコー図学会学術集会, 2011年4月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 玉井利奈, 冨田紀子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
徐脈を呈する高齢者の左室弛緩能についての検討:僧帽弁口血流速パターンをどう解釈するか,
第22回日本心エコー図学会学術集会, 2011年4月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第22回日本心エコー図学会学術集会, 2011年4月. 竹谷善雄, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 佐田政隆 :
三次元心エコー法により術前診断ができたペースメーカーリードの弁尖穿通による重症三尖弁逆流の一例,
第22回日本心エコー図学会学術集会, 2011年4月. 玉井利奈, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
心エコー検査で診断された肺高血圧症連続387例の基礎疾患と三尖弁輪運動速波形指標,
第22回日本心エコー図学会学術集会, 2011年4月. 高島啓, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 遠藤桂輔, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
リアルタイム3次元経食道心エコーガイド下に経皮的僧帽弁交連切開術を行った僧帽弁狭窄症の1例,
第22回日本心エコー図学会学術集会, 2011年4月. 山田博胤, 遠藤桂輔, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 佐田政隆 :
陳旧性心筋梗塞症におけるV1誘導のP terminal forceの臨床的意義: 心エコー・ドプラ法を用いた検討,
第22回日本心エコー図学会学術集会, 2011年4月. S. Bando, Takeshi Soeki, Toshiyuki Niki, Y. Hirata, N. Tomita, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) Level is Elevated in Patients with Cancer.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 添木武, 仁木敏之, 山口浩司, S. Bando, 上田由佳, N. Tomita, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2011年3月. S. Nishio, Hirotsugu Yamada, Kenya Kusunose, N. Tomita, S. Hayashi, K. Endo, R. Tamai, J. Miki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Which Noninvasive Vascular Index is the Best Predictor of the Severity of Coronary Atherosclerosis?,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Hayashi, Hirotsugu Yamada, S. Nishio, N. Tomita, Kenya Kusunose, K. Endo, R. Tamai, S. Bando, S. Hisaoka, H. Takeuchi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Motion Velocity in Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Toshiyuki Niki, Takeshi Soeki, S. Bando, Kenya Kusunose, S. Hisaoka, S. Hayashi, Yuka Ueda, S. Tomita, H. Takeuchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Kenya Kusunose, Hirotsugu Yamada, N. Tomita, S. Nishio, S. Bando, S. Hisaoka, S. Hayashi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, S. Bando, S. Hisaoka, S. Hayashi, Yuka Ueda, N. Tomita, H. Takeuchi, Kenya Kusunose, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Coagulative Response to Zotarolimus-eluting, Sirolimus-eluting and Bare-metal Stents Implanted in Patients with Stable Angina.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, S. Bando, S. Hisaoka, Toshiyuki Niki, Kenya Kusunose, N Tomita, Y. Hirata, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, M. Harada and Masataka Sata :
Diagnostic Utility of Cardiac Magnetic Resonance for Prediction of Cardiac Events in Patients with Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Toshiyuki Niki, Kenya Kusunose, N. Tomita, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Analysis of Tissue Characteristics of In-Stent Restenotic Lesion 5-Years after Coronary Stenting with Drug-Eluting Stent Using Integrated Backscatter Intravascular Ultrasound.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 高柳友貴, 仁木敏之, 坂東左知子, 久岡白陽花, 林修司, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 中山泰介, 北川哲也, 村野栄一 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 原田雅史 :
拡張型心筋症として診断・加療されていた心サルコイドーシスの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 髙尾正一郎, 原田雅史 :
心サルコイドーシスにおける左室形態異常の多様性,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 太田理絵, 冨田紀子, 楠瀬賢也, 坂東左知子, 久岡白陽花, 林修司, 竹内秀和, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 木村建彦, 西内健, 黒部裕嗣, 北川哲也 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 髙島啓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 竹崎彰夫, 多田浩也, 曽根三郎 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 竹内秀和, 久岡白陽花, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Fibrinogen relates to free triiodothyronin (FT3) negatively, which might be regulated via Hdac3.,
第97回日本循環器学会四国地方会, Feb. 2011. 小笠原梢, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 竹崎彰夫, 多田浩也, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第97回日本循環器学会四国地方会, 2010年12月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 平田陽一郎, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 岩瀬俊, 赤池雅史, 佐田政隆 :
二種類の上室性頻拍出が認められた例,
第97回日本循環器学会四国地方会, 2010年12月. 高柳友貴, 仁木敏之, 山田博胤, 楠瀬賢也, 山口浩司, 岩瀬俊, 冨田紀子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の1例,
第97回日本循環器学会四国地方会, 2010年12月. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷義雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスの1例,
第97回日本循環器学会四国地方会, 2010年12月. 末広英也, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第103回日本内科学会四国地方会, 2010年11月. 山崎宙, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第103回日本内科学会四国地方会, 2010年11月. 遠藤桂輔, 斉藤憲, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 林修司, 添木武, 赤池雅史, 佐田政隆 :
高度僧帽弁輪石灰化による多発性脳梗塞の1例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 太田理恵, 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
産後の甲状腺機能亢進が診断の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 河野裕美, 山田博胤, 佐藤光代, 西尾進, 冨田紀子, 遠藤桂輔, 楠瀬賢也, 添木武, 赤池雅史, 佐田政隆 :
Intramural hematoma(IMH)を呈したStanford B型大動脈解離の二例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 玉井利奈, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 楠瀬賢也, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
三次元心エコー法により術前診断ができたペースメーカーリードの弁尖穿通による重症三尖弁逆流の一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 遠藤桂輔, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
徐脈の高齢者において僧帽弁口血流波形がE>Aを呈するメカニズムについての検討,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 山田博胤, 三代裕一郎, 楠瀬賢也, 仁木敏之, 林修司, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高齢者および壮年者における高圧利尿薬インダパミドの少量追加投与の有効性と安全性-連日投与と隔日投与の比較-,
第33回日本高血圧学会総会, 2010年10月. 山口浩司, 若槻哲三, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 麻植塚浩康 :
冠動脈プラークに対する薬剤多面的効果の検討-Integrated backscatter IVUS観察による観点から-,
第58回日本心臓病学会学術集会, 2010年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステントによる冠動脈内皮機能障害の経年変化に関する検討,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
S字状中隔を呈する例の心エコー・ドプラ所見についての検討,
第58回日本心臓病学会学術集会, 2010年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 平田陽一郎, 冨田紀子, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
脳性ナトリウム利尿ペプチド(BNP)と癌との関係について,
第58回日本心臓病学会学術集会, 2010年9月. 添木武, 仁木敏之, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 冨田紀子, 平田陽一郎, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンの心臓自律神経への作用と心血管系における意義,
第58回日本心臓病学会学術集会, 2010年9月. 林修司, 山田博胤, 中田拓史, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形用いた左室拡張能評価の限界:E>Aパターンを呈する高齢者での検討,
第58回日本心臓病学会学術集会, 2010年9月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
EPA/AA比は冠動脈疾患の重症度に相関する:徳島大学病院循環器内科データベースを用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み慢性期における冠動脈局所凝固異常に対するスタチンの効果,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 楠瀬賢也, 玉井利奈, 遠藤桂輔, 西尾進, 三木淳子, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第58回日本心臓病学会学術集会, 2010年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張型心筋症の左室内同期不全に対する前負荷増大の影響:3次元心エコー法を用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 三木淳子, 竹崎彰夫, 多田浩也, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndoromeの1例,
第58回日本心臓病学会学術集会, 2010年9月. 門田宗之, 楠瀬賢也, 竹谷善雄, 坂東左知子, 久岡白陽花, 仁木敏之, 冨田紀子, 竹内秀和, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆, 坂東正章, 清水渉 :
KCNH2遺伝子にダブル異変を認めた先天性QT延長症候群の兄弟例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 山崎宙, 山口浩司, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 福永豊, 中西秀樹 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年8月. 太田理絵, 仁木敏之, 岩瀬俊, 坂東左知子, 久岡白陽花, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 原田雅史, 髙尾正一郎 :
軽微な臨床経過にもかかわらず心臓MRI検査にて異常所見を認めた急性心筋炎の1例,
第241回徳島医学会学術集会(平成22年度夏期), 2010年7月. 小笠原梢, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆, 北川哲也 :
IgA腎症ともやもや病を合併した若年発症の感染性心内膜炎の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 坂東美佳, 山口浩司, 岩瀬俊, 楠瀬賢也, 仁木敏之, 冨田紀子, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度拡張不全による心不全症状の再燃を認めた心尖部肥大型心筋症の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 坂東正章, 清水渉, 佐田政隆 :
KCNH2遺伝子にダブル変異を認めた先天性QT延長症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 楠瀬賢也, 竹谷善雄, 西尾進, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
右腎癌摘出後に心不全を繰り返した腎動脈狭窄症の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心電図異常が乏しいBrugada症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 鹿草宏, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
急性大動脈解離の1例,
日本内科学会第102回四国地方会, 2010年5月. 原知也, 仁木敏之, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 関啓 :
大動脈二尖弁における感染性心内膜炎に合併した大動脈弁輪周囲膿瘍の1例,
日本内科学会第102回四国地方会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
虚血の診断に有用な指標は何か?,
日本超音波医学会第83回学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
卵円孔開存の診断におけるコントラストリアルタイム3次元経食道心エコー法の有用性,
日本超音波医学会第83回学術集会, 2010年5月. 高島弘光, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三村千尋, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
大動脈弁硬化における頸動脈の動脈硬化所見の検討,
日本超音波医学会第83回学術集会, 2010年5月. 山田博胤, 楠瀬賢也, 西尾進, 河野裕美, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
下肢陽圧負荷時の僧帽弁口血流速波形の反応性を用いた軽症心不全患者の予後予測:''前負荷ストレス心エコー法''の臨床応用,
日本超音波医学会第83回学術集会, 2010年5月. 竹谷善雄, 若槻哲三, 山田博胤, 山口浩司, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 小柴邦彦, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
スタチンによる冠動脈プラーク性状の短期変化についてのIB-IVUSを用いた検討,
第21回日本心エコー図学会学術集会, 2010年5月. 林修司, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
3次元経食道心エコー(3D-TEE)法にて経過が観察できた巨大左心耳血栓の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
リアルタイム3次元経食道エコー法により観察しえた孤立性僧帽弁クレフトの1例,
第21回日本心エコー図学会学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 岩瀬俊, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心アミロイドーシスにおける心筋局所ストレインとMRIガドリニウム遅延造影所見の比較,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
コントラスト心エコー法で診断した肝肺症候群の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心病変を認めた多発性筋炎の一例,
第21回日本心エコー図学会学術集会, 2010年5月. 中田拓史, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形がE>Aパターンを呈する高齢者の内訳,
第21回日本心エコー図学会学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆, 平岡葉月 :
心エコー・ドプラ指標により前負荷軽減に対する心反応性は予測できるか,
日本超音波医学会四国地方会, 2009年12月. 西尾進, 山田博胤, 遠藤桂輔, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 楠瀬賢也, 冨田紀子, 多田津陽子, 添木武, 佐田政隆 :
卵円孔にトラップされた下肢静脈遊離血栓の1例∼3D経食道心エコー法による観察∼,
日本超音波医学会四国地方会, 2009年12月. 遠藤桂輔, 齋藤憲, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 添木武, 佐田政隆, 西尾進, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子 :
心エコー図検査で偶然発見された乳頭状線維弾性腫の2例,
日本超音波医学会四国地方会, 2009年12月. 阪田美穂, 早渕康信, 井上美紀, 香美祥二, 添木武 :
川崎病発症7年後にWPW症候群を呈し，15年後に発作性心房細動を呈した1例,
第15回四国心臓病フォーラム, 2009年10月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
シロリムス溶出性ステント留置後における局所凝固反応とステント長の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 足立克仁, 八木秀介, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 原田雅史, 西谷弘, 佐田政隆 :
Duchenne型筋ジストロフィー女性キャリアにおける心病変早期検出の試み-心臓MRIによる検討-,
第57回日本心臓病学会学術集会, 2009年9月. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
大動脈弁硬化の進行に関連する因子,
第57回日本心臓病学会学術集会, 2009年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
Th1/Th2バランスの改善を介したPravastatinの実験的自己免疫性心筋炎抑制効果,
第57回日本心臓病学会学術集会, 2009年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後慢性期の冠動脈局所炎症と凝固異常遷延の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 佐藤光代, 平岡葉月, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ASD，PSに合併した右室転移性腫瘤の1例,
第57回日本心臓病学会学術集会, 2009年9月. 添木武, 仁木敏之, 小柴邦彦, 楠瀬賢也, 平田陽一郎, 山口浩司, 八木秀介, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
血漿pentraxin3 (PTX3)濃度は冠動脈不安定プラークの指標となり得るか?,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の開始時間の差は左室拡張末期圧を反映する:下肢陽圧負荷を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 近藤可菜, 八木秀介, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者に対するAdaptive-servo ventilator療法の効果,
第239回徳島医学会学術集会, 2009年8月. 平田陽一郎, 仁木敏之, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 黒部裕嗣, 神原保, 筑後文雄, 北川哲也, 堀貴樹 :
冠動脈周囲脂肪組織におけるマクロファージ浸潤の動脈硬化病変形成に与える影響,
第239回徳島医学会学術集会, 2009年8月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 冨田紀子, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの二例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 小柴邦彦, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 竹谷善雄, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆 :
多発性筋炎に伴う心障害の一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
安静時post systolic shortening による虚血心筋の検出,
日本超音波医学会第82回学術集会, 2009年5月. 西尾進, 山田博胤, 楠瀬賢也, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
下肢静脈血栓スクリーニング検査で発見されたベーカー嚢胞破裂の2症例,
日本超音波医学会第82回学術集会, 2009年5月. 八木秀介, 岩瀬俊, 赤池雅史, 山口浩司, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者における酸素療法とAdaptive-servo ventilator療法の効果の比較検討,
日本内科学会第100回四国地方会, 2009年5月. 佐藤光代, 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
経食道心エコー検査により治療経過が観察できた高安動脈炎に伴う肺動脈狭窄症の一例,
第20回日本心エコー図学会学術集会, 2009年4月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 高松直子, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第20回日本心エコー図学会学術集会, 2009年4月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
三尖弁輪運動速波形を用いた二次性肺高血圧の評価,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Post systolic shortening(PSS)による心筋虚血の検出,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の不整合は左室拡張能の評価に有用か:dual Doppler systemを用いた検討,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 冨田紀子, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 河野智彦, 佐田政隆 :
右心不全を契機に診断された肺動脈狭窄症の一例,
第93回日本循環器学会四国地方会, 2008年12月. 八木秀介, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
強皮症に伴う難治性末梢循環不全に対するエンドセリン受容体拮抗薬の有用性,
第93回日本循環器学会四国地方会, 2008年12月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
両側肺血栓症と多発性体循環系塞栓症を合併した1例,
第93回日本循環器学会四国地方会, 2008年12月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
冠動脈ステント3種(CYPHER, TAXUS, DRIVER)の慢性期病理組織所見の比較と局所凝固反応の関連性,
第93回日本循環器学会四国地方会, 2008年12月. 住友由佳, 粟飯原賢一, 伊勢孝之, 吉田守美子, 松本俊夫, 八木秀介, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
ヘパリンコファクターⅡは抗酸化ストレス作用を介してアンジオテンシンIIによる心房および心室のリモデリングを抑制する,
第31回日本高血圧学会総会, 2008年10月. 西尾進, 山田博胤, 楠瀬賢也, 佐藤光代, 高松直子, 添木武, 赤池雅史, 佐田政隆 :
頸動脈狭窄性病変におけるB-Flowの有用性,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 山中森晶, 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
壁運動正常例におけるpost systolic shortening (PSS) についての検討,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 阿部美保, 河野和弘, 角谷昭佳, 佐田政隆 :
リアルタイム3次元経食道心エコー図で診断しえた肺動脈狭窄症の一例,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 西尾進, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 永峰康孝, 佐田政隆 :
Automated Function Imaging法による左室局所壁運動異常評価:心エコー初心者による肉眼的評価との比較,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高血圧性心疾患における左房ポンプ機能の評価:Left Atrial Ejection Forceを用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後の冠動脈内皮機能障害と局所炎症遷延の関連性,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 仁木敏之, 添木武, 小柴邦彦, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 福田大和, 篠原尚典, 福田信夫, 田村禎通, 佐田政隆 :
虚血性心疾患におけるHMGBI (high mobility group box 1) の診断的意義,
第56回日本心臓病学会学術集会, 2008年9月. 八木秀介, 粟飯原賢一, 伊勢孝之, 吉田守美子, 住友由佳, 池田康将, 岩瀬俊, 添木武, 赤池雅史, 松本俊夫 :
ピタバスタチンはRac-1を介した酸化ストレス制御によりeNOS非依存的にアンジオテンシンIIによる心房リモデリングを抑制する,
第40回日本動脈硬化学会総会, 203, 2008年7月.

(キーワード): *Angiotensin II 抗酸化剤(治療的利用) 心房 *動脈硬化症(薬物療法) 酸化ストレス rac GTP-Binding Proteins 心室リモデリング *Pitavastatin(治療的利用) マウス動物

武知かおる, 山田博胤, 楠瀬賢也, 西尾進, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 長楽雅仁, 前田泰弘 :
Automated Function Imaging法による左室局所壁運動異常評価のvalidation (VANILLA study),
第81回日本超音波医学会学術集会, 2008年5月. 岡田早未, 山田博胤, 楠瀬賢也, 佐藤光代, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧性心疾患における左室リモデリングと左室拡張能の関連,
第81回日本超音波医学会学術集会, 2008年5月. 佐藤光代, 山田博胤, 楠瀬賢也, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧患者における心電図の左房負荷は何を表しているか?-心エコー・ドプラ法による再検討-,
第81回日本超音波医学会学術集会, 2008年5月. 楠瀬賢也, 山田博胤, 河野裕美, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 添木武, 赤池雅史 :
心房細動症例におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第81回日本超音波医学会学術集会, 2008年5月. 平岡葉月, 山田博胤, 岡田早未, 楠瀬賢也, 佐藤光代, 河野裕美, 西尾進, 添木武 :
高血圧患者における左室肥大の心電図診断はどのくらい正確か?,
第19回日本心エコー図学会学術集会, 2008年4月. 楠瀬賢也, 武知かおる, 西尾進, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 長楽雅仁, 前田泰弘, 山田博胤 :
Longitudinal Strainを用いたAutomated Function Imaging法による左室局所壁運動異常評価のvalidation (VANILLA study),
第19回日本心エコー図学会学術集会, 2008年4月. 西尾進, 山田博胤, 楠瀬賢也, 添木武, 河野裕美, 平岡葉月, 佐藤光代 :
陳旧性心筋梗塞症における前負荷増大時の心反応性には左房機能が関与する:左房容積曲線を用いた検討,
第19回日本心エコー図学会学術集会, 2008年4月. T Niki, Takeshi Soeki, Kenya Kusunose, K Yamaguchi, K Koshiba, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Tomohito Kawano, Hirotsugu Yamada and Takeshi Soeki :
Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, T Niki, K Koshiba, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada and Tetsuzo Wakatsuki :
Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Takeshi Soeki, K Koshiba, T Niki, Kenya Kusunose, K Yamaguchi, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki and Kenji Kangawa :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Takeshi Soeki and Hirotsugu Yamada :
Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Left Atrial Volume dose not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Kenya Kusunose, Hirotsugu Yamada, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. Hirotsugu Yamada, Kenya Kusunose, A Iga, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki and Tetsuzo Wakatsuki :
E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.,
72th Annual scientific meeting of the Japanese circulation society, Mar. 2008. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 阿部美保, 北川哲也 :
両心房腫瘤の一例,
第102回UCG談話会, 2008年2月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
特定の薬物療法が功を奏した心房頻拍の1例,
第97回日本内科学会四国地方会, 2007年12月. 楠瀬賢也, 添木武, 仁木敏之, 山口浩司, 小柴邦彦, 山田博胤, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史 :
心エコーで心室中隔瘤の診断に苦慮した心サルコイドーシスの一例,
第91回日本循環器学会四国地方会学術集会, 2007年11月. 楠瀬賢也, 山田博胤, 佐藤光代, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三 :
肥大型心筋症の僧帽弁口血流速波形における左房機能の影響:左房容積曲線を用いた検討,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 佐藤光代, 山田博胤, 楠瀬賢也, 岩瀬俊, 平岡葉月, 河野裕美, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
不可解な心電図異常を呈する親子,
第17回日本超音波医学会四国地方会学術集会, 2007年10月. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 谷口哲三, 髙尾正一郎 :
不可解な心電図異常を呈し，肥大型心筋症を疑う1例,
第12回中国四国心筋症研究会, 2007年9月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化病変と血中ケモカイン濃度との関連性,
第55回日本心臓病学会学術集会, 2007年9月. 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 若槻哲三 :
冠動脈硬化症と血漿pentraxin3(PTX3)値の関係,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 山崎聖広, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
断層心エコー法による左房容積の計測およびそれにおける僧帽弁逆流の影響,
第55回日本心臓病学会学術集会, 2007年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 河野智仁, 山田博胤, 若槻哲三 :
C型ナトリウム利尿ペプチドは自己免疫性心筋炎の進展を抑制する,
第55回日本心臓病学会学術集会, 2007年9月. 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 三代裕一郎 :
アンギオテンシンⅡ受容体拮抗薬(ARB)投与症例におけるインダパミド少量追加投与の効果,
第55回日本心臓病学会学術集会, 2007年9月. 楠瀬賢也, 山田博胤, 濱本秀一, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動における拡張早期僧帽弁輪運動速度の心室中隔側および左室側壁側における差の検討-Dual Doppler法を用いて-,
第55回日本心臓病学会学術集会, 2007年9月. 楠瀬賢也, 山田博胤, 添木武, 佐藤光代, 河野裕美, 平岡葉月 :
改良された2D Tissue Tracking法を用いた左房容積変化の評価,
第80回日本超音波医学会学術集会, 2007年5月. 河野裕美, 山田博胤, 楠瀬賢也, 添木武, 佐藤光代, 平岡葉月, 永峰康孝 :
Dual-Doppler法を用いた僧帽弁口血流速および僧帽弁輪運動速波形の同時記録による左房細動における左室拡張能の評価,
第18回日本心エコー図学会学術集会, 2007年4月. 楠瀬賢也, 山田博胤, 添木武, 佐藤光代, 河野裕美, 平岡葉月, 永峰康孝 :
心房細動におけるRR間隔の変動に伴う僧帽弁輪運動速度の変化,
第18回日本心エコー図学会学術集会, 2007年4月. 山田博胤, 楠瀬賢也, 添木武, 佐藤光代, 河野裕美, 平岡葉月 :
心房細動における前負荷増大に伴う心反応性の下半身陽圧負荷およびDual Doppler法を用いた検討,
第18回日本心エコー図学会学術集会, 2007年4月. Kenya Kusunose, Hirotsugu Yamada, T Nakajima, T Niki, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Simultaneously Recorded E/Ew Refletcts Plasma BNP Level in Patients with Atrial Fibrillation.,
71th Annual scientific meeting of the Japanese circulation society, Mar. 2007. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第89回日本循環器学会四国地方会, 2006年12月. 中島智博, 添木武, 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 河野智仁, 山田博胤, 伊東進 :
PP間隔が不規則な上室性頻拍に対しCARTOを用いたAblationが有用であった1例,
第89回日本循環器学会四国地方会, 2006年12月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第16回日本超音波医学会四国地方会, 2006年10月. 若槻哲三, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 山田博胤 :
薬剤溶出ステントは長期に冠動脈局所の内皮機能を障害する,
第54回日本心臓病学会学術集会, 2006年9月. 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
心房細動に対するCoupled Pacing におけるペーシング遅延時間の差による影響,
第54回日本心臓病学会学術集会, 2006年9月. 中島智博, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
ヒト心房性利尿ペプチドの間歇投与が有効な拡張層家族性肥大型心筋症の1例,
第11回中四国心筋症・心不全研究会, 2006年9月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
徳島心エコー図研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換により出現する低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第4回先進血管エコー研究会, 2006年8月. 楠瀬賢也, 山田博胤, 中島智博, 仁木敏之, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 伊東進 :
体位変換性の低酸素血症の診断にコントラスト心エコー法が有用であった一例,
第98回UCG談話会, 2006年7月. 山田博胤, 河野裕美, 福田大和, 添木武, 田畑智継, 伊東進 :
下半身陽圧負荷による僧帽弁口血流速波形の変化を用いた心房機能低下例の鑑別,
第17回日本心エコー図学会学術集会, 2006年4月. Tetsuzo Wakatsuki, Koji Yamaguchi, Kunihiko Koshiba, Tomohito Kawano, Takeshi Soeki, Yamato Fukuda, Hirotsugu Yamada and Susumu Ito :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent,
第70回日本循環器学会総会・学術集会, Mar. 2006. Takeshi Soeki, Yamato Fukuda, Kunihiko Koshiba, Koji Yamaguchi, Tomohito Kawano, Tomohito Kawano, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masahiro Nomura, Kenji Kangawa and Susumu Ito :
Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis,
第70回日本循環器学会総会, Mar. 2006. Hirotsugu Yamada, H Motonari, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Susumu Ito :
Effect of Aging on Left Atrial Function Evaluated by 2D Tissue Tracking.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. Hirotsugu Yamada, Y Fukuda, K Yamaguchi, K Koshiba, Tomohito Kawano, Takeshi Soeki, Tetsuzo Wakatsuki, Susumu Ito and Y Mishiro :
The Effects of the Addition of Minimal Dose of Indapamide in Patients Receiving Angiotensin-II Receptor Blocker.,
70th Annual scientific meeting of the Japanese circulation society, Mar. 2006. 山口浩司, 若槻哲三, 福田大和, 小柴邦彦, 河野智仁, 山田博胤, 添木武, 岩瀬俊, 藤村光則, 赤池雅史, 東博之 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの一例,
第87回日本循環器学会中国・四国合同地方会, 2005年11月. 河野裕美, 山田博胤, 福田大和, 添木武, 田畑智継, 伊東進 :
下半身陽圧負荷による僧帽弁口血流速波形の変化を用いた心房機能低下例の鑑別,
日本超音波医学会四国地方会第15回学術集会, 2005年10月. 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 福田大和, 山田博胤, 田畑智継, 森一博 :
川崎病既往成人例および一般高齢者における冠動脈病変の特徴の差異 ―冠動脈内温度変化の観点から―,
第53回日本心臓病学会学術集会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会, 2005年9月. 河野智仁, 福田大和, 渡部智紀, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アトルバスタチンの抗酸化作用と冠動脈プラーク安定化の評価:16列マルチスライスCTを用いた検討,
第53回日本心臓病学会, 2005年9月. 福田大和, 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武 :
不安定プラークに対するDES hot spot stentingを考えさせられた一例,
第12回日本心血管インターベンション学会・第2回日本心血管カテーテル治療学会中国・四国合同地方会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
ドキソルビシン心筋症ラットにおける顆粒球コロニー刺激因子投与によるアポトーシス抑制効果の検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
本態性高血圧症におけるアゼルニジピンの自律神経活動に及ぼす影響についての検討,
第53回日本心臓病学会学術集会, 2005年9月. 小柴邦彦, 河野智仁, 福田大和, 渡部智紀, 山口浩司, 山田博胤, 添木武, 若槻哲三, 田畑智継, 野村昌弘 :
アゼルニジピンによる抗動脈硬化作用および心肥大抑制作用の検討,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 長野智章 :
2D tissue tracking 法を用いた左房容積変化の評価,
第53回日本心臓病学会学術集会, 2005年9月. 田畑智継, 山田博胤, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
ストレインイメージング法を用いた僧帽弁口血流速波形の偽正常化の再評価:左房機能との関係において,
第53回日本心臓病学会学術集会, 2005年9月. 山田博胤, 田畑智継, 本成永, 田中英治, 福田大和, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三 :
2D組織トラッキング法を用いた左房リザーバー機能の評価,
第53回日本心臓病学会学術集会, 2005年9月. 福田大和, 若槻哲三, 山口浩司, 小柴邦彦, 河野智仁, 添木武 :
DES時代におけるhot spot stentingを考えさせられた一例,
第32回徳島心血管造影研究会, 2005年7月. Takeshi Soeki, Ichiro Kishimoto, Hiroshi Hosoda, Morikatsu Yoshida, Takeshi Tokudome, Takeshi Horio, D O Schwenke Daryl, Pearson T. James, Mikiyasu Shirai and Kenji Kangawa :
Ghrelin Suppresses Cardiac Sympathetic Activity and Attenuates Early Left Ventricular Remodeling in Rats with Myocardial Infarction,
第69回日本循環器学会総会, Mar. 2005. Takeshi Soeki, Ichiro Kishimoto, Takeshi Tokudome, Kenji Mori, Takeshi Horio and Kenji Kangawa :
C-type Natriuretic Peptide, a Novel Antifibrotic Agent, Attenuates Cardiac Remodeling and Improves Left Ventricular Dysfunction in Dilated Cardiomyopathy,
第69回日本循環器学会総会, Mar. 2005. 添木武, 岸本一郎, 徳留健, 堀尾武史, 寒川賢治 :
C型ナトリウム利尿ペプチドは拡張型心筋症ハムスターにおける心筋の線維化と心機能障害を抑制する,
第8回日本心血管内分泌代謝学会, 2004年11月. 添木武, 岸本一郎, 奥村啓之, 徳留健, 堀尾武史, 寒川賢治 :
C型ナトリウム利尿ペプチドは心筋梗塞後リモデリングを抑制する,
第7回日本心血管内分泌代謝学会, 2003年11月. 添木武, 田村禎通, 篠原尚典, 酒部宏一, 小野瀬由紀子, 澤田幸, 福田信夫 :
冠動脈疾患における血漿VE-cadherin値の臨床的意義,
第49回日本心臓病学会学術集会, 2001年9月. 添木武, 田村禎通, 篠原尚典, 酒部宏一, 小野瀬由紀子, 澤田幸, 福田信夫 :
冠動脈硬化患者において血小板PAI-1は心事故発生を予測しえるか?,
第49回日本心臓病学会学術集会, 2001年9月. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Koichi Sakabe, Yukiko Onose, Yuki Sawada and Nobuo Fukuda :
Plasma soluble VE-cadherin concentration in patients with coronary artery disease,
第65回日本循環器学会総会, Mar. 2001. Takeshi Soeki, Yoshiyuki Tamura, Hisanori Shinohara, Koichi Sakabe, Yukiko Onose, Yuki Sawada and Nobuo Fukuda :
Circulating soluble Fas ligand predicts subsequent ventricular remodeling following myocardial infarction,
第65回日本循環器学会総会, Mar. 2001. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 近藤幸, 福田信夫 :
冠動脈硬化症と局所HGF産生能の関係 -特に糖尿病の影響について,
第48回日本心臓病学会学術集会, 2000年9月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 近藤幸, 福田信夫 :
急性心筋梗塞における可溶性PECAM-1およびICAM-1の動態,
第48回日本心臓病学会学術集会, 2000年9月. 添木武, 福田信夫, 篠原尚典, 田中英治, 板東完治, 森宏仁, 田村禎通 :
甲状腺機能の改善に伴い心筋Integrated backscatter値に改善を認めた甲状腺機能亢進症の1例:甲状腺ホルモンによる左室心筋障害検出の可能性について,
第73回日本超音波医学会, 2000年5月. 添木武, 福田信夫, 篠原尚典, 田中英治, 板東完治, 田村禎通 :
僧帽弁輪石灰化症例における左室流入血流および僧帽弁輪速度に関する検討,
第11回日本心エコー図学会, 2000年4月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 森宏仁, 福田信夫 :
急性心筋梗塞におけるアポトーシスの関与とその臨床的意義 -Fas/Fas-L系からの検討-,
第97回日本内科学会総会, 2000年4月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 森宏仁, 福田信夫 :
心筋梗塞後リモデリングと血清HGFおよびVEGF濃度との関係,
第64回日本循環器学会総会, 2000年4月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 森宏仁, 福田信夫 :
急性心筋梗塞における血中sFasおよFas-Lの動態,
第64回日本循環器学会総会, 2000年4月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 森宏仁, 福田信夫 :
線溶系因子は心筋梗塞二次発症を予測しえるか?,
第64回日本循環器学会総会, 2000年4月. 添木武, 田村禎通, 篠原尚典, 田中英治, 板東完治, 由井靖子, 福田信夫 :
急性心筋梗塞における血清VEGFおよびHGFの経時的変動とその意義 —CRP，血清アミロイドA蛋白との関係—,
第47回日本心臓病学会学術集会, 1999年9月. 添木武, 田村禎通, 篠原尚典, 武市直樹, 田中英治, 板東完治, 由井靖子, 福田信夫 :
急性心筋梗塞の早朝発症における凝固線溶系因子および血小板活性化因子の役割,
第63回日本循環器学会総会, 1999年3月. 添木武, 田村禎通, 篠原尚典, 武市直樹, 田中英治, 板東完治, 由井靖子, 福田信夫 :
急性心筋梗塞における血清VEGFおよびHGFの経時的変化,
第63回日本循環器学会総会, 1999年3月. 添木武, 田村禎通, 篠原尚典, 武市直樹, 田中英治, 板東完治, 由井靖子, 福田信夫 :
虚血性心疾患における血清VEGFおよびHGFの動態,
第63回日本循環器学会総会, 1999年3月. 添木武, 田村禎通, 坂東完治, 田中英治, 武市直樹, 篠原尚典, 由井靖子, 福田信夫 :
心事故発生の危険因子に関する検討 -線溶系，血清脂質およびCRPについて-,
第46回日本心臓病学会学術集会, 1998年9月. 添木武, 田村禎通, 武市直樹, 篠原尚典, 由井靖子, 福田信夫 :
急性心筋梗塞における血漿および血小板内Plasminogen Activator Inhibitor-1(PAI-1)の経時的変化について,
第45回日本心臓病学会学術集会, 1997年9月. 添木武, 田村禎通, 武市直樹, 篠原尚典, 由井靖子, 福田信夫 :
慢性心不全に対するエナラプリル長期投与の効果 -123I-MIBG心筋シンチによる検討-,
第45回日本心臓病学会学術集会, 1997年9月. 福田信夫, 武市直樹, 添木武, 篠原尚典, 由井靖子, 田村禎通, 田畑智継, 井内新, 山田博胤, 大木崇 :
左室流出路狭窄における血中ナトリウム利尿ペプチド(ANP, BNP)濃度測定の意義,
第45回日本心臓病学会, 1997年9月. 添木武, 田村禎通, 武市直樹, 篠原尚典, 由井靖子, 福田信夫 :
虚血性心疾患における血漿および血小板内Plasminogen Activator Inhibitor-1(PAI-1)の動態について,
第61回日本循環器学会総会, 1997年3月. 添木武, 田村禎通, 篠原尚典, 武市直樹, 由井靖子, 小田修治, 久保謙一郎, 四宮寛彦 :
シンポジウム「冠動脈疾患の病態」:急性心筋梗塞における線溶活性変動の意義について,
第51回国立病院療養所総合医学会, 1996年10月. 添木武, 田村禎通, 四宮寛彦, 武市直樹, 篠原尚典, 由井靖子, 福田信夫 :
急性心筋梗塞における線溶系因子の変動と意義について,
第44回日本心臓病学会学術集会, 1996年9月. 福田信夫, 四宮寛彦, 添木武, 武市直樹, 篠原尚典, 由井靖子, 田村禎通, 田畑智継, 井内新, 山田博胤, 阿部美保, 大木崇 :
左室流出路狭窄における脳性ナトリウム利尿ペプチドの分泌動態,
第7回弁と弁疾患研究会, 1996年8月. 添木武, 福田信夫, 四宮寛彦, 由井靖子, 田村禎通 :
冠血流予備能の著明な低下を示した心アミロイドーシスの1例,
第67回日本超音波医学会, 1996年6月.

研究会・報告書: 村上貴寛, 八木秀介, 原知也, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 春藤譲治, 佐田政隆 :
原発性アルドステロン症の診断に有用な臨床所見の検討,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 山上圭, 西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 原知也, 上野理絵, 門田宗之, 齋藤友子, 山﨑宙, 坂東左知子, 伊藤浩敬, 轟貴史, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 佐田政隆 :
生体腎移植後における腎静脈-外腸骨静脈間の血流動態変化が一因と考えられた深部静脈血栓症の一例,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 山下雄也, 坂東美佳, 伊勢孝之, 楠瀬賢也, 山田博胤, 原知也, 高島啓, 山﨑宙, 斎藤友子, 坂東左知子, 飛梅威, 山口浩司, 八木秀介, 添木武, 若槻哲三, 木下肇, 藤本鋭貴, 北川哲也, 井上洋行, 佐田政隆 :
収縮期雑音を契機に発見された成人単純型大動脈狭窄症の1例,
第251回徳島医学会学術集会, 2015年8月. 瀬野弘光, 山﨑宙, 八木秀介, 黒部裕嗣, 高森信行, 楠瀬賢也, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
急激な弁破壊を認めたメチシリン感受性表皮ブドウ球菌による感染性心内膜炎の一例,
第251回徳島医学会学術集会, 2015年8月. 阪田美穂, 早渕康信, 香美祥二, 森一博, 井上美紀, 添木武, 飛梅威, 松浦朋美, 坂東佐知子, 佐田政隆, 北市隆, 藤本鋭貴, 神原保, 黒部裕嗣, 北川哲也, 小野寺睦雄, 今中秀光, 西村匡司 :
経皮的心肺補助(PCPS)装着下にカテーテルアブレーションを施行し，救命し得た異所性接合部頻拍の1男児例,
第141回日本小児科学会徳島地方会, 2013年12月. 坂東左知子, 添木武, 松浦朋美, 飛梅威, 佐田政隆 :
Aorta-mitral continuityが起源の心房頻拍の1例,
第25回カテーテルアブレーション委員会公開研究会, 2013年11月. 松浦朋美, 飛梅威, 添木武, 坂東左知子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 佐田政隆 :
室房ブロックを伴っても持続する2種類の房室結節リエントリー性頻拍を認め，上位共通路の存在が示唆された1例,
第25回カテーテルアブレーション委員会公開研究会, 2013年11月. Takeshi Soeki, T Matsuura, S Bando, E Uematsu, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, I Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmia by preserving connexin 43 protein.,
第36回心筋代謝研究会, Jul. 2013. 添木武, 山田博胤, 松浦朋美, 坂東左知子, 坂東美佳, 佐田政隆 :
カテーテルアブレーションハンズオンセミナー,
第4回四国研修会, 2012年7月. 坂東美佳, 山田博胤, 西尾進, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 髙島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
質低下療法による頸動脈プラーク安定化の評価,
第5回T0kushima Young Investigators Conference, 2012年3月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 西尾進, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 佐田政隆 :
Fabry病の2家系,
第16回中四国心筋症・心不全研究会, 2011年9月. 岩瀬俊, 伊勢孝之, 小笠原梢, 山崎宙, 高島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 能勢隼人, 原田雅史, 赤池雅史, 足立克仁 :
Duchenne型筋ジストロフィー女性キャリアの心病変検出における心臓MRI検査の有用性,
第16回中四国心筋症・心不全研究会, 2011年9月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 能勢隼人, 髙尾正一郎, 大塚秀樹, 原田雅史, 西岡安彦 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第16回中四国心筋症・心不全研究会, 2011年9月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 發知淳子, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 佐田政隆 :
高齢者の左室弛緩能に心拍数が与える影響について:僧帽弁口血流速パターンをどう解釈するか,
第1回四国symphony, 2011年7月. 林修司, 山田博胤, 楠瀬賢也, 冨田紀子, 多田津陽子, 西尾進, 玉井利奈, 岩瀬俊, 添木武, 佐田政隆 :
体位変換により右室内圧較差が変化をきたす右室二腔症の一例,
UCG談話会, 2011年1月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
陳旧性心筋梗塞症における心電図左房負荷所見の意義:心エコー・ドプラ法を用いた検討,
心・血管クラスターミニリトリート, 2011年1月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
左室内同期不全に対する前負荷の影響拡張型心筋症における下肢陽圧負荷3次元心エコー法を用いた検討,
先進血管エコー研究会, 2010年8月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 玉井利奈, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
心電図異常を指摘され，心エコー検査で発見された左室緻密化障害の1例,
第3回蔵本エコーカンファレンス, 2010年7月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第8回先進血管エコー研究会, 2009年8月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
第11回徳島脳卒中研究会, 2009年2月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
脳卒中研究会, 2009年2月. 野村昌弘, 河野智仁, 小柴邦彦, 山口浩司, 渡辺智紀, 福田大和, 添木武, 齋藤憲, 中屋豊, 中安紀美子 :
平均心拍数および血圧と冠動脈病変の評価, --- マルチスライスCTおよび心拍変動解析を用いた検討 ---,
第53回日本心臓病学会学術集会, 2005年9月.

特許: 研究者総覧に該当データはありませんでした。
作品: 八木秀介, 福田大受, 平田有紀奈, GANBAATAR BYAMBASUREN, Arief Rahadian, 伊勢孝之, 楠瀬賢也, 山田博胤, 山口浩司, 松浦朋美, 飛梅威, 曽我朋宏, 添木武, 若槻哲三, 川人伸次, 佐田政隆 :
【糖尿病専門医に必要な心不全の知識update】SGLT2阻害薬と心不全(解説/特集),
糖尿病・内分泌代謝科, Vol.52, No.3, 257-264, 2021年11月.
補助金・競争的資金: 遺伝子改変マウスと未固定遺体を用いた動脈硬化の新規の病態解明と治療法の開発 (研究課題/領域番号: 22H03069 )
PAR-2シグナルによる心臓特異的炎症機構の解明と新たな心臓病治療法の開発 (研究課題/領域番号: 20K08492 )
動脈硬化の進展と破綻における新規の慢性炎症惹起機構の解明と治療法の開発 (研究課題/領域番号: 19H03654 )
TLR9シグナルによる心臓リモデリングと不整脈発生メカニズムの解明 (研究課題/領域番号: 18K08077 )
動脈壁と血管周囲脂肪組織に生じる無菌的慢性炎症の病態解明と新規制御法の開発 (研究課題/領域番号: 16H05299 )
グレリンの多面的効果による難治性非虚血性心疾患治療法の開発 (研究課題/領域番号: 24591056 )
グレリンの自律神経作用を応用した循環器代謝疾患における橋渡し研究 (研究課題/領域番号: 24390204 )
心臓周囲への脂肪組織移植による冠動脈疾患に対する新規治療法の開発 (研究課題/領域番号: 23659420 )
動脈硬化プラーク脆弱化の分子機構の解明と急性冠症候群予測因子の同定 (研究課題/領域番号: 22390159 )
グレリンの自律神経作用を介した新しい不整脈治療法の開発 (研究課題/領域番号: 21590899 )
C型ナトリウム利尿ペプチドを用いた難治性心筋炎の診断・治療法の開発 (研究課題/領域番号: 19590820 )
グレリンの特異性を活かした新しい心臓治療法の開発 (研究課題/領域番号: 17790517 )
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2024年4月29日更新

専門分野・研究分野: 医学 (Medicine)
所属学会・所属協会: 研究者総覧に該当データはありませんでした。
委員歴・役員歴: 研究者総覧に該当データはありませんでした。
受賞: 2013年4月, 第24回日本心エコー図学会学術集会海外学会発表優秀論文賞 (日本心エコー図学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会研修医部門最優秀賞 (社団法人日本循環器学会)
2013年5月, 第102回日本循環器学会中国・四国合同地方会コメディカル部門最優秀賞 (社団法人日本循環器学会)
2013年8月, ESC Congress 2013 The Top Score Poster Award (European Society of Cardiology)
2013年10月, 日本超音波医学会第23回四国地方学術集会 The Best Imaging賞 (日本超音波医学会)
2013年12月, 第103回日本循環器学会四国地方会学生・研修医セッション奨励賞 (社団法人日本循環器学会)
2014年4月, 第25回日本心エコー図学会学術集会ベストポスター賞 (日本心エコー図学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期)若手奨励賞 (徳島医学会)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期) 若手奨励賞 (徳島医学会)
2014年8月, ESC Congress 2014 Young Investigator Award Clinical Science (ヨーロッパ心臓病学会)
2014年9月, 第62回日本心臓病学会学術集会優秀賞(優秀演題セッション口演1 一般) (日本心臓病学会)
2014年12月, 第105回日本循環器学会四国地方会コメディカルセッション奨励賞 (社団法人日本循環器学会)
2015年1月, 公益財團法人康樂會賞 (公益財団法人康楽会)
2015年3月, 平成26年度表彰論文優秀賞 (公益財団法人福田記念医療技術振興財団)
2015年8月, ESC Congress 2015 ベストポスター賞 (European Society of Cardiology)
2015年9月, 第63回日本心臓病学会学術集会若手症例Presenter賞 (日本心臓病学会)
2015年12月, 第19回日本心血管内分泌代謝学会若手研究奨励賞(YIA) (日本心血管内分泌代謝学会)
2016年2月, 第45回日本心脈管作動物質学会若手研究奨励賞(YIA) (日本心脈管作動物質学会)
2016年3月, 第5回日本循環器学会循環器臨床研究奨励賞(症例報告部門) (社団法人日本循環器学会)
2016年3月, 第3回日本循環器学会循環器イメージング賞 (社団法人日本循環器学会)
2016年6月, 第108回日本循環器学会中国・四国合同地方会「研修医奨励賞」 (日本心臓病学会)
2016年7月, 第253回徳島医学会学術集会(平成28年度夏期)「若手奨励賞」 (徳島医学会)
2016年9月, 第64回日本心臓病学会学術集会優秀演題セッション(医師部門)優秀賞 (日本心臓病学会)
2016年9月, KSC2016 Young Investigator's Award (The 60th Annual Scientific Meeting of The Korean Society of Cardiology)
2016年12月, 第109回日本循環器学会四国地方会学生・研修医奨励賞 (社団法人日本循環器学会)
2017年3月, Young Investigator's Award (Clinical Research ) (社団法人日本循環器学会)
2017年5月, 最優秀演題賞 (第47回臨床心臓電気生理研究会)
2017年9月, Young Investigators Award 最優秀賞 (第65回日本心臓病学会学術集会)
2018年6月, 研修医奨励賞 (第112回日本循環器学会中国・四国合同地方会)
2021年12月, 若手研究奨励賞 (第119回日本循環器学会四国地方会若手研究奨励賞)
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2024年4月27日更新

研究者番号: 60393211

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授

所属（過去の研究課題 情報に基づく）*注記: 2019/4/1 – 2023/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
2018/4/1 – 2019/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 准教授
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 准教授
2012/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 講師
2012/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2010/4/1 – 2011/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師
2005/4/1 – 2009/4/1 : 徳島大学, 医学部・歯学部附属病院, 講師

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 循環器内科学
小区分53020:循環器内科学関連

研究代表者以外

生物系 / 医歯薬学 / 内科系臨床医学 / 循環器内科学
小区分53020:循環器内科学関連

キーワード

研究代表者

グレリン / ペプチド / 心臓病 / 心臓リモデリング / 治療 / アポトーシス / 自律神経 / 循環器・高血圧 / 生理活性 / 薬理学 / ナトリウム利尿ペプチド / 心筋炎 / 診断 / 生理活性ペプチド / 循環器 / Toll-like 受容体 / 心房細動 / 不整脈 / 慢性炎症

研究代表者以外

動脈硬化 / 血管新生 / 慢性炎症 / HMGB-1 / 急性冠症候群プラーク破裂 / 循環器・高血圧 / 急性冠症候群 / プラーク破裂 / プラーク / 自然免疫 / マクロファージ / サイトカイン / 生活習慣病 / 脂肪 / 移植 / 炎症 / 外膜 / グレリン / 自律神経 / 糖尿病 / トランスレーショナルリサーチ / 生理活性 / メタボリックシンドローム / インスリン抵抗性 / 肥満 / 自己核酸 / 脂肪組織 / 血管 / 循環器 / プロテアーゼ活性化受容体(PAR) / 心房細動 / 心筋梗塞 / プロテアーゼ活性化受容体（PAR） / PAR2 / FXa / 心臓慢性炎症 / 脂質異常症 / アポトーシス / STING / Toll様受容体 / 骨髄

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添木 武

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