トップ›研究者を探す›一過性の脳虚血障害が脳内アミロイドβ代謝と認知症発症に与える影響についての検討

一過性の脳虚血障害が脳内アミロイドβ代謝と認知症発症に与える影響についての検討

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17K11084
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
麻酔科学
研究機関 愛媛大学
代表研究者 閔 莉娟
研究分担者 茂木 正樹
研究分担者 堀内 正嗣
研究分担者 岩波 純
研究期間 開始年月日 2017/4/1
研究期間 終了年度 2019
研究ステータス 完了 (2019/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2019年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2018年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2017年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード 脳血管障害
脳虚血
Aβタンパク
認知障害
神経炎症
神経変性
AT2受容体
脳血管保護作用
Aβ脳室内投与
脳血管老化
炎症・酸化ストレス
神経細胞障害
Aβ投与
血管老化
認知機能
血管障害
アミロイドアンギオパチー
アミロイドβの血管クリアランス機構
レニン・アンジオテンシン系

研究成果

[雑誌論文] Deterioration of cognitive function after transient cerebral ischemia with amyloid-beta infusion-possible amelioration of cognitive function by AT2 receptor activation

Min LJ, Iwanami J, Shudou M, Bai HY, Shan BS, Higaki A, Mogi M, Horiuchi M 2020

[学会発表] ヘスペリジンは血管障害モデルマウスにおける血管リモデリングを抑制する

成本葵、岩波純、成本悠、川上萌、山口りさこ、菅野晴美、茂木正樹、閔莉娟、堀内正嗣 2019

[学会発表] Chronic Cerebral Damage Aggravates Vascular Remodeling in Cuff-Induced Vascular Injury Mouse Model

Iwanami J, Mogi M, Tsukuda K, Higaki A, Kukida M, NakaokaH, Bai HY, Shan BS, Min LJ, Horiuchi M 2019

[雑誌論文] AT2 receptor stimulation inhibits phosphate-induced vascular calcification

Kukida M, Mogi M, Kan-No H, Tsukuda K, Bai HY, Shan BS, Yamauchi T, Higaki A, Min LJ, Iwanami J, Okura T, Higaki J, Horiuchi M 2019

[学会発表] 胎児発育遅延による脳障害へのアンジオテンシンII2型受容体の保護効果

成本悠、岩波純、単宝帥、茂木正樹、成本葵、閔莉娟、堀内正嗣 2019

[学会発表] ヘスペリジンは血管障害モデルマウスにおける血管リモデリングを抑制する

成本葵、岩波純、成本悠、川上萌、山口りさこ、菅野晴美、茂木正樹、閔莉娟、堀内正嗣 2019

[学会発表] 胎児発育遅延による脳障害へのアンジオテンシンII2型受容体の保護効果

成本悠、岩波純、単宝帥、茂木正樹、成本葵、閔莉娟、堀内正嗣 2019

[雑誌論文] Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Yamauchi T, Tsukuda K, Kan-No H, Ikeda S, Higaki J, Horiuchi M 2018

[雑誌論文] Roles of angiotensin II type 2 receptor in mice with fetal growth restriction

Yamauchi T, Mogi M, Kan-No H, Shan BS, Higaki A, Min LJ, Higaki T, Iwanami J, Ishii EI, Horiuchi M 2018

[雑誌論文] Predicting outcome of Morris water maze test in vascular dementia mouse model with deep learning

Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Kan-No H, Ikeda S, Higaki J, Horiuchi M 2018

[学会発表] Amelioration of Ischemic Brain Injury by Angiotensin II Type 2 Receptor Stimulation via Peroxisome Proliferator-Activated Receptor-gamma Activation

Shan BS, Mogi M, Iwanami J, Kan-no H, Bai HY, Higaki A, Min LJ, Horiuchi M 2018

[雑誌論文] Attenuation of stroke damage by angiotensin II type 2 receptor stimulation via peroxisome proliferator-activated receptor-gamma activation

Shan BS, Mogi M, Iwanami J, Bai HY, Kan-No H, Higaki A, Min LJ, Horiuchi M 2018

[学会発表] T2 receptor stimulation-induced protective effect on ischemic brain damage is enhanced by AT2 receptor-interacting protein

Mogi M, Iwanami J, Bai HY, Shan BS, Min LJ, Liu S, Horiuchi M 2018

[雑誌論文] Roles of angiotensin II type 2 receptor in mice with fetal growth restriction

Yamauchi T, Mogi M, Kan-No H, Shan BS, Higaki A, Min LJ, Higaki T, Iwanami J, Ishii EI, Horiuchi M 2018

[学会発表] Synergistic Effect of Angiotensin II and Amyloid-β on Brain Vascular Smooth Muscle Cell Senescence

Min LJ, Bai HY, Shan BS, Kan-no H, Higaki A, Mogi M, Iwanami J, Horiuchi M 2018

[雑誌論文] Deletion of interferon-regulatory factor-1 results in cognitive impairment

Mogi M, Iwanami J, Wang XL, Tsukuda K, Kan-No H, Bai HY, Shan BS, Higaki A, Min LJ, Horiuchi M 2018

[学会発表] Angiotensin II and Amyloid-β Synergistically Induce Brain Vascular Smooth Muscle Cell Senescence

Min LJ, Bai HY, Shan BS, Kan-no H, Higaki A, Iwanami J, Mogi M, Horiuchi M 2018

[学会発表] Hesperidin in citrus fruit juice plays a role in preventing cognitive impairment induced by ischemic brain damage

Kawakami M, Iwanami J, Tsukuda K, Higaki A, Min LJ, Mogi M, Horiuchi M 2018

[学会発表] Interaction between Ischemic Brain Damage and Amyloid-beta Infusion in Cognitive Impairment ~Possible Amelioration of Cognitive Function by AT2 Receptor Activation~

Min LJ, Mogi M, Bai HY, Shan BS, Higaki A, Iwanami J, Horiuchi M 2018

[学会発表] Cerebral Ischemia with Amyloid-beta Infusion Deteriorates Cognitive Decline ~Possible Amelioration of Cognitive Function by AT2 Receptor Activation~

Min LJ, Mogi M, Bai HY, Shan BS, Higaki A, Iwanami J, Horiuchi M 2018

[学会発表] 生活習慣病予防よりみた認知症改善へのアプローチ

岩波純、堀内正嗣 2018

[学会発表] Chronic cerebral ischemic injury worsens vascular dysfunction

Iwanami J, Mogi M, Tsukuda K, Higaki A, Kawakami M, Kukida M, NakaokaH, Yamauchi T, Bai HY, Shan BS, Min LJ, Horiuchi M 2018

[雑誌論文] Recognition of early stage thigmotaxis in Morris water maze test with convolutional neural network

Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kan-No H, Ikeda S, Higaki J, Horiuchi M 2018

[雑誌論文] Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Yamauchi T, Tsukuda K, Kan-No H, Ikeda S, Higaki J, Horiuchi M 2018

[学会発表] Cross-talk between amyloid-beta and angiotensin II in brain vascular smooth muscle cell senescence

Hui-Yu Bai, Li-Juan Min, Bao-shuai Shan, Harumi Kan-no, Akinori Higaki, Jun Iwanami, Masaki Mogi and Masatsugu Horiuchi 2017

[学会発表] Interaction between Ischemic Brain Injury and Amyloid-beta Deposition in Cognitive Decline; Possible Cognitive Protection by AT2 Receptor Activation

Li-Juan Min, Masaki Mogi, Kana Tsukuda, Hui-Yu Bai, Bao-Shuai Shan, Akinori Higaki, Jun Iwanami and Masatsugu Horiuchi 2017

[学会発表] 認知機能における虚血性脳障害とアミロイドβの相互作用～AT2受容体による相互作用抑制効果の可能性～

閔　莉娟、茂木正樹、檜垣彰典、岩波　純、堀内正嗣 2017

[学会発表] Interaction between Stroke and Amyloid-beta Deposition in Cognitive Function~Possible Involvement of Antagonist Effect of AT2 Receptor Activation~

Li-Juan Min, Masaki Mogi, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Toshifumi Yamauchi, Xiao-Li Wang, Hui-Yu Bai, Bao-Shuai Shan, Jun Iwanami and Masatsugu Horiuchi 2017

[学会発表] 虚血性脳障害とアミロイドβの認知機能における相互作用~AT2受容体による相互作用抑制効果の可能性~

閔　莉娟、茂木正樹、佃　架奈、白　薈鈺、単　宝帥、檜垣彰典、岩波　純、堀内正嗣 2017