トップ›研究者を探す›卵巣機能の低下が中枢・末梢のストレス反応に及ぼす影響とその機序の検討

卵巣機能の低下が中枢・末梢のストレス反応に及ぼす影響とその機序の検討

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26462526
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
産婦人科学
研究機関 徳島大学
代表研究者 岩佐 武
研究分担者 苛原 稔
研究分担者 松崎 利也
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額（合計） 3,250,000 (直接経費 :2,500,000、間接経費 :750,000)
配分額（履歴） 2016年度：910,000 (直接経費 :700,000、間接経費 :210,000)
2015年度：780,000 (直接経費 :600,000、間接経費 :180,000)
2014年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード ストレス
卵巣
視床下部
脂肪組織
visfatin
性腺ホルモン
心理ストレス
感染ストレス
サイトカイン

研究成果

[雑誌論文] Gonadotropin-inhibitory hormone plays roles in stress-induced reproductive dysfunction.

Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Minoru Irahara 2017

[雑誌論文] The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Sumika Matsui, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Eri Takiguchi, Takako Kawakita, Akira Kuwahara, Toshiyuki Yasui and Minoru Irahara 2016

[学会発表] 雌ラットにおいてテストステロンが体重・摂食量に及ぼす影響は性腺ホルモン環境により異なる

岩佐　武、松崎利也、Munkhsaikhan Munkhzaya、Altankhuu Tungalagsuvd、馬依拉　伊利亜斯、苛原　稔 2016

[雑誌論文] Effects of chronic testosterone administration on body weight and food intake differ among pre-pubertal, gonadal-intact, and ovariectomized female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Mayila Yiliyasi, Takeshi Kato, Akira Kuwahara, and Minoru Irahara 2016

[雑誌論文] 電気化学発光免疫測定法(ECLIA法)を用いたエストラジオール測定キット「エクルーシス試薬プロゲステロンIII」の基本性能評価および基準範囲の検討

松崎利也, 岩佐　武, 徳井貴子, Yiliyasi Mayila, 杉本　光, 苛原　稔 2016

[学会発表] ストレスが視床下部におけるKiss1およびRFRP遺伝子発現と生殖機能に及ぼす影響

岩佐　武 2016

[学会発表] Comparison of AMH and FSH as an indicator of ovarian reserve in ART.

Mikio Yamasaki, Akira Kuwahara, Yuka Taniguchi, Yuri Yamamoto, Takeshi Iwasa, Kenji Hinokio, Toshiya Matsuzaki, Minoru Irahara 2015

[雑誌論文] Effects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats.

57.Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2015

[学会発表] Survey on oncologist and gynecologist concerned with fertility for cancer survivors in reproductive age.

Akiko Abe, Masato Nishimura, Eri Takiguchi, Takako Kawakita, Yuka Taniguchi, Yuri Yamamoto, Mikio Yamasaki, Takeshi Iwasa, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara 2015

[学会発表] Suppressive effect of immune stress on LH secretion is absent in early neonatal period in rats.

Munkhsaikhan Munkhzaya, Toshiya Matsuzaki, Takeshi Iwasa, Altankhuu Tungalagsuvd, Takako Kawami, Minoru Irahara 2015

[学会発表] Hypothalamic Kiss1 and RFRP gene expressions are changed by a high dose of lipopolysaccharide in female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Takako Kawami, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Minoru Irahara 2015

[学会発表] 卵巣摘出が中枢・末梢のストレス反応に与える影響

岩佐　武、松崎利也、苛原　稔 2015

[雑誌論文] Developmental changes in the hypothalamic mRNA levels of prepro-orexin and orexin receptors and their sensitivity to fasting in male and female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2015

[学会発表] Senktide does not recover suppression of HPG axis induced by acute fasting in male rats.

Altankhuu Tnugalagsuvd, Toshiya Matsuzaki, Takeshi Iwasa, Munkhsaikhan Munkhzaya, Takako Kawami, Minoru Irahara 2015

[雑誌論文] The effects of ovariectomy and LPS-induced endotoxemia on resistin levels in female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Sumika Matsui, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takako Kawami, Mikio Yamasaki, Masahiro Murakami, Takeshi Kato, Akira Kuwahara, Toshiyuki Yasui and Minoru Irahara 2015

[学会発表] Clinical significance of estradiol and transvaginal ultrasonography for pregnancy outcomes in natural frozen-thawed blastcyst transfer cycles.

Akira Kuwahara, Kenji Hinokio, Yuka Taniguchi, Yuri Yamamoto, Mikio Yamasaki, Takeshi Iwasa, Minoru Irahara 2015

[雑誌論文] Developmental changes in hypothalamic toll-like-receptor 4 mRNA expression and the effects of lipopolysaccharide on such changes in female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takako Kawami, Mikio Yamasaki, Masahiro Murakami, Takeshi Kato, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2015

[雑誌論文] 電気化学発光免疫測定法(ECLIA法)を用いたエストラジオール測定キット「エクルーシス試薬E2 IV」の基本性能評価および基準範囲の検討

松崎利也, 岩佐　武, 河見貴子, Mayila Yiliyasi, 高松典通, 土井俊夫, 苛原　稔 2015

[学会発表] Efficacy and pregnant outcomes of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical endometrial hyperplasia in young women.

Masato Nishimura, Eri Takiguchi, Takako Kawakita, Akiko Abe, Yuka Taniguchi, Yuri Yamamoto, Mikio Yamasaki, Takeshi Iwasa, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara 2015

[雑誌論文] The effects of LPS-induced endotoxemia on the expression of adiponectin and its receptors in female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Sumika Matsui, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Takako Kawami, Masahiro Murakami, Takeshi Kato, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2014

[学会発表] 卵巣摘出が中枢・末梢のストレス反応に及ぼす影響

岩佐　武、松崎利也、苛原　稔 2014

[学会発表] 卵巣摘出による中枢・末梢のストレス反応の変化

岩佐　武、松崎利也、苛原　稔 2014

[雑誌論文] Site-specific changes in cytokine response to septic dose of lipopolysaccharide in ovariectomized female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Ganbat Gereltsetseg, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Takako Kawami, Masahiro Murakami, Mikio Yamasaki, Yuri Yamamoto, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2014

[雑誌論文] 卵巣とストレス反応

岩佐　武、松崎利也、苛原　稔 2014

[雑誌論文] Changes in leptin production/secretion induced in response to septic doses of lipopolysaccharides in gonadally intact and ovariectomized female rats.

Takeshi Iwasa, Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Takako Kawami, Masahiro Murakami, Takeshi Kato, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara 2014

[雑誌論文] アディポサイトカインとゴナドトロピン分泌

松崎利也、岩佐　武、苛原　稔 2014