トップ研究者を探す頭蓋顎顔面領域高頻度疾患の原因究明から病態発症機序解明への最先端研究戦略

頭蓋顎顔面領域高頻度疾患の原因究明から病態発症機序解明への最先端研究戦略

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26293436
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
歯学
矯正・小児系歯学
研究機関 徳島大学
代表研究者 田中 栄二
研究分担者 井本 逸勢(橘逸勢)
研究分担者 泰江 章博
研究協力者 三井 なおみ
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 16,250,000 (直接経費 :12,500,000、間接経費 :3,750,000)
配分額(履歴) 2016年度:3,640,000 (直接経費 :2,800,000、間接経費 :840,000)
2015年度:5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
2014年度:7,280,000 (直接経費 :5,600,000、間接経費 :1,680,000)
キーワード ゲノム編集
遺伝子疾患
CRISPR/Cas
非症候性多数歯欠損
TALEN
突然変異導入

研究成果

[雑誌論文] Roles of hypoxia inducible factor-1α in the temporomandibular joint

Mino-Oka A, Izawa T, Shinohara T, Mori H, Yasue A, Tomita S, Tanaka E 2017

[学会発表] Rogdi Disrupted Mice Showed Amelogenesis Imperfecta-like Phenotype

Silvia Mitsui Naomi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari, Eiji Tanaka 2017

[雑誌論文] Hyaluronan metabolism in overloaded temporomandibular joint.

Shinohara T, Izawa T, Mino-Oka A, Mori H, Iwasa A, Inubushi T, Yamaguchi Y, Tanaka E 2016

[学会発表] Biological validation of tooth agenesis causing mutation using CRISPR/Cas system in mice.

Naomi Mitsui, Akihiro Yasue, Issei Imoto, Seiichi Oyadomari, Eiji Tanaka 2016

[学会発表] HIF-1α+/-マウスを用いた変形性顎関節症におけるHIF-1αの機能解析.

岡 彰子、井澤 俊、篠原丈裕、森 浩喜、田中栄二 2016

[雑誌論文] Dynamic and stress relaxation properties of the whole porcine temporomandibular joint disc under compression

Barrientos E, Pelayo F, Tanaka E, Lamela-Rey MJ, Fernandez-Canteli A 2016

[学会発表] Low-intensity pulsed ultrasound rescues insufficient salivary secretion in Sjogren syndrome.

Sato M, Mansjur KQ, Tanaka E 2016

[雑誌論文] The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis.

Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N 2016

[雑誌論文] Dynamic and stress relaxation properties of the whole porcine temporomandibular joint disc under compression.

Barrientos E, Pelayo F, Tanaka E, Lamela-Rey MJ, Fernandez-Canteli A 2016

[学会発表] Combined therapeutic effects of parathyroid hormone and low-intensity pulsed ultrasound enhance bone fracture healing in osteoporotic rats.

Mansjur KQ, Sato M, Tanaka E 2016

[学会発表] ゲノム編集技術を用いたマウス1細胞期胚における遺伝子変異導入.

泰江章博、田中栄二 2016

[雑誌論文] The effectiveness of human parathyroid hormone and low-intensity pulsed ultrasound treatments for the healing of farctures in osteoporotic bones.

Mansjur KQ, Kuroda S, Izawa T, Maeda Y, Sato M, Khariunaa G, Watanabe K, Horiuchi S, Tanaka E 2016

[雑誌論文] Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis.

Izawa T, Mori H, Shinohara T, Mino A, Hutami IR, Iwasa A, TanakaE. 2016

[雑誌論文] Smad3 decifiency leads to mandibular condyle degradation via the Sphingosine 1-phosphate (S1P) / S1P3 signaling axis.

Mori H, Izawa T, Tanaka E 2015

[雑誌論文] Low-intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis.

Sato M, Kuroda S, Mansjur KQ, Ganzorig K, Nagata K, Horiuchi S, Inubushi T, Yamamura Y, Azuma M, Tanaka E 2015

[学会発表] Study of Pax6-deficient mosaic mice generated by the CRISPR/Cas system.

Akihiro Yasue, Hitomi Kono, Tetsuya Bando, Yoshiyasu Ishimaru, Junji Inoue, Takahiro Watanabe, Seiichi Oyadomari, Sumihare Noji, Taro Mito, Hideyo Ohuchi, Eiji Tanaka 2015

[学会発表] Sequence analysis and in vitro study of novel mutations identified in patients with tooth agenesis

Mitsui SN, Yasue A, Matsuda K, Watanabe K, Horiuchi S, Imoto I, Tanaka E 2014

[学会発表] Mutation affecting the C-terminal of MSX1 causes non-syndromic tooth agenesis

Mitsui SN, Yasue A, Tanaka E 0

[学会発表] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems

Yasue A, Mitsui SN, Watanabe T, Sakuma T, Oyadomari S, Yamamoto T, Noji S, Mito T, Tanaka E 0

[学会発表] CRISPR/CasシステムによるPax6遺伝子破壊マウスの解析

河野仁美、泰江章博、石丸善康、井上順治、渡辺崇仁、板東哲哉、親泊政一、野地澄晴、三戸太郎、山本卓、田中栄二、大内淑代 0