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田中栄二

徳島大学

プロフィール
教育活動
研究活動
社会活動
リサーチマップ・
Jグローバル
KAKEN
注目研究

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2024年12月20日更新

職名: 教授
電話: 088-633-7356
電子メール: etanaka@tokushima-u.ac.jp
学歴: 1982/4: 大阪大学歯学部歯学科入学
1988/3: 大阪大学歯学部歯学科卒業
1989/4: 大阪大学大学院歯学研究科歯学臨床系専攻博士課程入学
1993/3: 大阪大学大学院歯学研究科歯学臨床系専攻博士課程修了
学位: 博士(歯学) (大阪大学) (1993年3月)
職歴・経歴: 2008/4: 徳島大学教授, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学教授, 大学院医歯薬学研究部

専門分野・研究分野: 歯科矯正学 (Orthodontics)

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2024年12月20日更新

専門分野・研究分野: 歯科矯正学 (Orthodontics)
担当経験のある授業科目: (臨床系)国家試験・CBT対策講義 (学部)
口腔と健康 (共通教育)
口腔保健推進予防歯学概論 (大学院)
口腔顎顔面矯正学 (大学院)
口腔顎顔面矯正学演習 (大学院)
実践口腔科学実習 (大学院)
小児口腔保健学 (大学院)
歯周病学概論 (大学院)
歯科矯正学 (学部)
歯科矯正学実習 (学部)
歯科矯正学A 講義 (学部)
歯科矯正学B 講義 (学部)
歯科矯正学総論 (学部)
歯科臨床示説 (学部)
発達系歯科学 (学部)
研究基礎ゼミ (学部)
統合臨床講義 (学部)
総合歯科学三 (学部)
総合歯科学二 (学部)
臨床医科学概論 (大学院)
臨床心理学 (大学院)
顎口腔発育・社会歯科学実験実習 (大学院)
指導経験: 4人 (博士)

研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 歯科矯正学 (Orthodontics)

研究テーマ: 顎関節症の病因
診断
治療, 歯周組織に対する超音波照射, 顎関節の生体力学 (顎関節 (temporomandibular joint), 超音波 (ultrasound), 臨床矯正歯科学 (clinical orthodontics), 生体力学 (biomechanics), 粘弾性特性 (viscoelasticity))

著書

田中栄二 :
診療研究特発性下顎頭吸収とは何か,
全国保険医団体連合会, 東京, 2022年. 田中栄二 :
「イトーD function」を用いた咀嚼筋痛障害の非侵襲的治療,
株式会社デンタルダイヤモンド社, 東京, 2022年. 田中栄二 :
⑤顎変形症の種類．PART 1 顎変形症とは．,
クインテッセンス出版株式会社, 東京, 2022年5月. 市原亜起, 渡邉佳一郎, 堀内信也, 田中栄二 :
アンカースクリューによって|3埋伏歯の開窓牽引を行った症例,
医歯薬出版株式会社, 東京, 2019年. 岩浅亮彦, 小笠原直子, 田中栄二 :
アンカースクリューを植立し|6欠損スペースを利用して上顎前突の改善を行った症例．,
医歯薬出版株式会社, 東京, 2019年. 堀内信也, 田中栄二 :
Colum:アンカースクリュー臨床のヒント∼こういうときはこうやって使うと効果的．,
医歯薬出版株式会社, 東京, 2019年11月. 田中栄二, 岡彰子, 荒井大志, 天眞寛文 :
アンカースクリューを用いた上顎歯列全体の圧下によりガミースマイルを改善した症例．,
医歯薬出版株式会社, 東京, 2019年11月. 岩浅亮彦, 小笠原直子, 田中栄二 :
アンカースクリューを固定源として下顎大臼歯の整直を行った症例．,
医歯薬出版株式会社, 東京, 2019年11月. 森浩喜, 堀内信也, 田中栄二 :
アンカースクリューを使用して上下顎全歯の遠心移動と挺出を行い叢生および過蓋咬合を改善した症例,
医歯薬出版株式会社, 東京, 2019年11月. 森浩喜, 谷本幸多朗, 田中栄二 :
3. 森浩喜，谷本幸多朗，田中栄二(2019):アンカースクリューにより上顎臼歯部を圧下し下顎頭吸収に起因した前歯部開咬を改善した症例,
医歯薬出版株式会社, 東京, 2019年11月. 堀内信也, 田中栄二 :
Colum:アンカースクリューの破折．,
医歯薬出版株式会社, 東京, 2019年11月. 田中栄二 :
歯科矯正学第6版, --- 14章矯正歯科治療における固定 ---,
医歯薬出版株式会社, 東京, 2019年1月. 堀内信也, 田中栄二 :
GUMMETALワイヤーを用いた臨床一工夫―金属アレルギー患者を対象としてー．,
ロッキーマウンテンモリタ，東京., 東京, 2018年. 田中栄二, 天眞寛文, 森浩喜, 渡邉佳一郎 :
B-maxスクリュー Type-TKを用いた成人開咬の治療戦略,
クインテッセンス出版株式会社, 東京, 2018年. Minami Sato, Toshihiro Inubushi and Eiji Tanaka :
Application of LIPUS to Salivary Glands. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. Eiji Tanaka, Tatsuya Nakamura, Minami Sato, Kaur Harmanpreet and El-Bialy Tarek :
Application of LIPUS to the Temporomandibular Joint. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. Eiji Tanaka, Toshihiro Inubushi and El-Bialy Tarek :
Application of LIPUS to Periodontal Tissue Regeneration. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. Eiji Tanaka, Kumiko Nagata and Nobuhiko Kawai :
Application of LIPUS to Skeletal Muscles. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. MANSJUR KARIMA QURNIA and Eiji Tanaka :
Application of LIPUS for Bone Healing. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. Tanabe Natsuko, Akihiro Yasue and Eiji Tanaka :
Mechanisms of LIPUS on Dentofacial Bioengineering. In: Therapeutic Ultrasound in Dentistry - Applications for Dentofacial Repair, Regeneration, and Tissue Engineering,
Springer, Gewerbestrasse, Switzerland,, 2018. 田中栄二 :
顎関節症と歯科矯正治療との関連の変遷,
横浜, 2018年8月. Nishio Clarice, Eiji Tanaka, Turgeon Daniel and Nanci Antonio :
Facial Growth and Development. In: Ten Cates Oral Histology,,
Elsevier, 2017. 田中栄二 :
日本顎関節学会学術用語集,
クインテッセンス出版株式会社, 2017年7月. 田中栄二, 川合暢彦 :
矯正,
医歯薬出版株式会社, 東京, 2017年2月. 田中栄二 :
口腔科学における骨と筋,
メディカルレビュー社, 東京, 2015年11月. 田中栄二 :
矯正歯科,
株式会社バリューメディカル, 東京, 2015年8月. 黒田晋吾, 田中栄二 :
基礎からわかる! 歯科矯正用アンカースクリューエビデンスに基づく安全・確実な使用法,
クインテッセンス出版株式会社, 2014年10月. 田中栄二, 堀内信也 :
顎関節症状を有する骨格性開咬に対する歯科矯正学的アプローチ,
クインテッセンス出版株式会社, 2014年2月. 川上恵実, 田中栄二, 砂田芳秀, 土田邦博, 野地澄晴 :
マイオスタチンの発現抑制による治療について,
2011年4月. 近藤優子, 田中栄二 :
口唇裂患者の形成術後の口唇における血流分布にかかわる研究,
クインテッセンス出版株式会社, 東京, 2010年9月. 田中栄二 :
Ⅶ 歯列不正，先天異常への対応,
医歯薬出版株式会社, 東京, 2009年9月. 川添亜希, 宮内睦美, 山野栄三, 石角篤, 田中栄二, 牧野武利, 犬伏俊博, Emanuel Braga Rego, 丹根一夫, 高田隆 :
大豆レシチンによるリポソーム化ラクトフェリン経口投与がリポポリサッカライド誘導歯周組織破壊に及ぼす抑制効果,
日本医学館, 東京, 2009年7月. 山野栄三, 宮内睦美, 川添亜希, 石角篤, 田中栄二, 水道裕久, 今中宏真, 牧野武利, 犬伏俊博, 丹根一夫, 高田隆 :
リポポリサッカライド誘導歯周組織破壊に及ぼすリポソーム化ラクトフェリン経口投与の抑制効果, --- 骨芽細胞による破骨細胞形成に及ぼすラクトフェリンの抑制効果 ---,
日本医学館, 東京, 2009年7月.

論文

Sonoko Okuhashi, Masaru Kobayashi and Eiji Tanaka :
Severe Maxillary Protrusion Treated with Surgically Assisted Rapid Maxillary Expansion,
Journal of Clinical Medicine, Vol.13, No.13, 4149, 2024.

(要約): In this case, surgically assisted rapid maxillary expansion (SARME) was successfully adopted to treat a skeletal maxillary protrusion with large overjet and severe crowding. The female patient, aged 25 years and 11 months, was diagnosed with skeletal maxillary protrusion with severe crowding and excessive overjet associated with labially inclined maxillary central incisors. After achieving sufficient space for surgical incision between bilateral maxillary central incisors, the SARME was performed. A total of 8.0 mm lateral expansion of the maxilla was completed. At 48 days after surgery, the Hyrax appliance was replaced with an Anchor-Lock system used as an external surgical stent and skeletal anchorage for maxillary group distalization, and the distal movement of the maxillary molars was initiated without waiting for bone healing of the separated midpalatal suture by SARME. Twenty-five months' treatment, including surgical preparation, achieved an acceptable and stable occlusion with adequate interincisal relationship. The occlusion was much more stable with a little relapse through more than 4 years' retention period. In conclusion, SARME followed by the Anchor-Lock system might lead to favorable occlusal outcome in the long term without any relapses.
(キーワード): surgically assisted rapid maxillary expansion / maxillary protrusion / maxillary group distalization / Anchor-Lock system
(徳島大学機関リポジトリ): ● Metadata: 119517
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm13144149
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85199869156

(徳島大学機関リポジトリ: 119517, DOI: 10.3390/jcm13144149, Elsevier: Scopus) Eiji Tanaka and Mercuri G. Louis :
Current status of the management of idiopathic condylar resorption / progressive condylar resorption - A scoping review,
Journal of Clinical Medicine, Vol.13, No.13, 3951, 2024.

(要約): The temporomandibular joint (TMJ) is a complex synovial joint shrouded in mystery, as the etiology of many TMJ disorders are unsolved. Idiopathic/progressive condylar resorption (ICR/PCR) is one such TMJ disorder characterized by a gradually deteriorating mandibular condylar mass, resulting in severe mandibular retrognathia, which often accompanied by clockwise rotation of mandible and an anterior open bite. Since the etiology of the ICR/PCR remains unclear, no definitive prevention or management options have been established. To date, various symptomatic non-surgical, surgical, and salvage management options have been developed and reported. To understand the current status of the ICR/PCR management options, this article provides an overview of the options presently reported in the literature to reduce its TMJ symptoms and improve mandibular function and form.
(徳島大学機関リポジトリ): ● Metadata: 119516
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm13133951
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38999512; ● Search Scopus @ Elsevier (PMID): 38999512; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm13133951

(徳島大学機関リポジトリ: 119516, DOI: 10.3390/jcm13133951, PubMed: 38999512) ODO BAYARSAIKHAN, Munkh-Erdene Ochirbal, Boldbaatar Tungalagtamir, Gantulga Oyundari and Eiji Tanaka :
Prevalence of malocclusion and orthodontic treatment need in 9-12 year-old schoolchildren in Ulaanbaatar, Mongolia,
Curēus, Vol.16, No.7, e65495, 2024.

(要約): Background The prevalence of malocclusion in Mongolia is increasing every year. Estimating the need for orthodontic treatment in the population is crucial for planning orthodontic care services and monitoring oral health programs. Therefore, the present study aimed to assess the need for orthodontic treatment among schoolchildren in Ulaanbaatar, Mongolia, using the Index of Orthodontic Treatment Need (IOTN). Methods A total of 656 schoolchildren aged 9-12 years were enrolled from 8 schools located in urban and suburban areas of 6 districts of Ulaanbaatar city. All the children were assessed according to the two components of the IOTN, the Dental Health Component (DHC) and the aesthetic component (AC). Statistical analyses were carried out using IBM SPSS Statistics for Windows, Version 28 (Released 2021; IBM Corp., Armonk, New York, United States). Results The prevalence of malocclusion was 561 (84.5%), consisting of 452 (68%) Angle Class I, 178 (26.8%) Angle Class II, and 34 (5.2%) Angle Class III malocclusion. For the DHC, the moderate need for treatment was 194 (29.3%) and the definite need was 53 (8.1%). For the AC, the moderate need was 148 (22.3%) and the definite need was 45 (6.9%). The association between the DHC and the AC was found to be statistically significant (p<0.001). The most common malocclusions were an increased overjet (maxillary protrusion), a contact point displacement (crowding), and an increased overbite (deep bite). The AC, Angle's molar relationship, an increased overjet, a contact point displacement, and an increased overbite were factors associated with the need for orthodontic treatment. Conclusion Approximately one-third of schoolchildren in Ulaanbaatar, Mongolia, require orthodontic treatment. This finding helps dental practitioners to better understand oral health problems, leading to an improvement in the overall quality of life of children.
(徳島大学機関リポジトリ): ● Metadata: 119578
(出版サイトへのリンク): ● Publication site (DOI): 10.7759/cureus.65495
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39188462; ● Search Scopus @ Elsevier (PMID): 39188462; ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.65495

(徳島大学機関リポジトリ: 119578, DOI: 10.7759/cureus.65495, PubMed: 39188462) Yuta Matsuki, Masahiro Hiasa, Shigeki HANAWA, Motosumi NAKAGAWA, Shinya Horiuchi and Eiji Tanaka :
A case of anterior open bite associated with idiopathic condylar resorption treated with miniscrew-assisted orthodontics,
AJO-DO Clinical Companion, Vol.4, No.3, 211-228, 2024.

(徳島大学機関リポジトリ): ● Metadata: 119698
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.xaor.2024.04.002
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.xaor.2024.04.002

(徳島大学機関リポジトリ: 119698, DOI: 10.1016/j.xaor.2024.04.002) Linze Xia, Fumiya Kano, Noboru Hashimoto, Yao Liu, Tsendsuren Khurel-Ochir, Naoko Ogasawara, Cheng Ding, Yang Xu, Hideharu Hibi, Tomonori Iwasaki, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium From Stem Cells of Human Exfoliated Deciduous Teeth Alleviates Mouse Osteoarthritis by Inducing sFRP1-Expressing M2 Macrophages.,
Stem Cells Translational Medicine, Vol.13, No.4, 399-413, 2024.

(要約): Intravenous administration of conditioned medium from stem cells of human exfoliated deciduous teeth (SHED-CM) regenerates mechanically injured osteochondral tissues in mouse temporomandibular joint osteoarthritis (TMJOA). However, the underlying therapeutic mechanisms remain unclear. Here, we showed that SHED-CM alleviated injured TMJ by inducing anti-inflammatory M2 macrophages in the synovium. Depletion of M2 by Mannosylated Clodrosome abolished the osteochondral repair activities of SHED-CM. Administration of CM from M2-induced by SHED-CM (M2-CM) effectively ameliorated mouse TMJOA by inhibiting chondrocyte inflammation and matrix degradation while enhancing chondrocyte proliferation and matrix formation. Notably, in vitro, M2-CM directly suppressed the catabolic activities while enhancing the anabolic activities of interleukin-1β-stimulated mouse primary chondrocytes. M2-CM also inhibited receptor activator of nuclear factor NF-κB ligand-induced osteoclastogenesis in RAW264.7 cells. Secretome analysis of M2-CM and M0-CM revealed that 5 proteins related to anti-inflammation and/or osteochondrogenesis were enriched in M2-CM. Of these proteins, the Wnt signal antagonist, secreted frizzled-related protein 1 (sFRP1), was the most abundant and played an essential role in the shift to anabolic chondrocytes, suggesting that M2 ameliorated TMJOA partly through sFRP1. This study suggests that secretome from SHED exerted remarkable osteochondral regeneration activities in TMJOA through the induction of sFRP1-expressing tissue-repair M2 macrophages.
(キーワード): Humans / Mice / Animals / Culture Media, Conditioned / Stem Cells / Macrophages / Osteoarthritis / Anti-Inflammatory Agents / Tooth, Deciduous
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/stcltm/szae006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38366885; ● Summary page in Scopus @ Elsevier: 2-s2.0-85190754023

(DOI: 10.1093/stcltm/szae006, PubMed: 38366885, Elsevier: Scopus) Keiichiro Watanabe, Eiji Tanaka, Kohei Kamoi, Antonin Tichy, Takahiko Shiba, Kazuhide Yonerakura, Masatoshi Nakajima, Ruonan Han and Keiichi Hosaka :
A dual composite resin injection molding technique with 3D-printed flexible indices for biomimetic replacement of a missing mandibular lateral incisor.,
Journal of Prosthodontic Research, 2024.

(要約): The bilayered direct composite RBFPD using 3D printed flexible indices prepared with a full digital workflow has several advantages over other dental prosthetic solutions, including noninvasiveness, cost-effectiveness, biomimetic esthetics, repairability, and shortened treatment times. Although the initial results are promising, further longitudinal studies with larger patient cohorts are required to confirm the long-term efficacy of this approach.
(出版サイトへのリンク): ● Publication site (DOI): 10.2186/jpr.JPR_D_23_00239
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38479888; ● Search Scopus @ Elsevier (PMID): 38479888; ● Search Scopus @ Elsevier (DOI): 10.2186/jpr.JPR_D_23_00239

(DOI: 10.2186/jpr.JPR_D_23_00239, PubMed: 38479888) Eiji Tanaka, Hiroshi Yamada, Masaaki Higashino, Masaki Sawada, Saya Suetake and Susumu Abe :
Influence of Orthodontic Treatment on Changes in the Maxillary Sinus Dimensions.,
Curēus, Vol.16, No.2, e53363, 2024.

(要約): Objective This study aimed to investigate the correlation of craniofacial morphology with maxillary sinus morphology and to evaluate whether orthodontic treatment facilitates maxillary sinus enlargement in adults. Materials and methods A total of 45 adult women underwent cephalography and computed tomography before and after orthodontic treatment. All participants were classified into three groups: skeletal class I, II, and III. The average dimensions and volume of the maxillary sinus were calculated in each subgroup. Furthermore, multiple regression analysis was used to analyze the correlations of maxillary sinus dimensions with 20 cephalometric variables. Results Before treatment, the maxillary sinus width, height, depth, and volume were 32.2 ± 3.9 mm, 39.5 ± 3.8 mm, 38.6 ± 1.8 mm, and 36,179.3 ± 5,454.0 mm3 in skeletal class I, 33.9 ± 6.2 mm, 37.3 ± 3.5 mm, 38.6 ± 2.4 mm, and 34,729.8 ± 6,686.6 mm3 in skeletal class II, and 32.0 ± 4.3 mm, 41.8 ± 5.0 mm, 38.0 ± 2.8 mm, and 35,592.3 ± 10,334.3 mm3 in skeletal class III, respectively. Despite no significant differences in maxillary sinus width, depth, or volume, the height was significantly lower in the skeletal class II than in the other two. Regardless of the skeletal pattern, maxillary sinus height and volume increased considerably after treatment. Moreover, the maxillary sinus width was substantially involved in pretreatment U1 to SN and overbite and posttreatment U1 to NA and overjet. Conclusion Except for the height, the maxillary sinus dimensions were almost similar, irrespective of the skeletal classification. The posttreatment sinus height and volume were significantly greater than the pretreatment values, although the sinus width and length showed no significant changes during orthodontic treatment. This implies that orthodontic treatment may facilitate the enlargement of the maxillary sinus even after physical growth.
(キーワード): volumetric change / orthodontic treatment / maxillary sinus / craniofacial morphology / computed tomography
(徳島大学機関リポジトリ): ● Metadata: 119577
(出版サイトへのリンク): ● Publication site (DOI): 10.7759/cureus.53363
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38435147; ● Search Scopus @ Elsevier (PMID): 38435147; ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.53363

(徳島大学機関リポジトリ: 119577, DOI: 10.7759/cureus.53363, PubMed: 38435147) Eiji Tanaka :
Etiology and Diagnosis for Idiopathic Condylar Resorption in Growing Adolescents.,
Journal of Clinical Medicine, Vol.12, No.20, 2023.

(要約): This article has been written in honor of the late professor emeritus Kazuo Tanne, who passed away on 4 March 2023 [...].
(徳島大学機関リポジトリ): ● Metadata: 119696
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm12206607
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37892745; ● Search Scopus @ Elsevier (PMID): 37892745; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm12206607

(徳島大学機関リポジトリ: 119696, DOI: 10.3390/jcm12206607, PubMed: 37892745) Shankargouda Patil, Shilpa Bhandi, J Khalid Alzahrani, M Mrim Alnfiai, Luca Testarelli, W Burke Soffe, W Frank Licari, H Kamran Awan and Eiji Tanaka :
Efficacy of laser in re-osseointegration of dental implants-a systematic review.,
Lasers in Medical Science, Vol.38, No.1, 2023.

(要約): Despite their high success rates, peri-implantitis can affect the stability and function of dental implants. Various treatment modalities have been investigated for the treatment of peri-implantitis to achieve re-osseointegration. An electronic literature search was performed supplemented by a manual search to identify studies published until January 2022. Articles that evaluated re-osseointegration in peri-implantitis sites in animal models following laser therapy or antimicrobial photodynamic therapy (aPDT) were included. Case reports, case series, systematic reviews, and letters to the editor were excluded. Risk of bias and GRADE assessment were followed to evaluate the quality of the evidence. Six studies out of 26 articles identified on electronic search were included in this review. The studies included animal studies conducted on canine models. Four out of six studies reported a higher degree of re-osseointegration following treatment of implants with laser therapy. The findings suggest that laser decontamination shows potential in enhancing re-osseointegration, particularly with the Er: YAG laser, which effectively decontaminated implant surfaces. However, conflicting outcomes and limitations in the evidence quality warrant caution in drawing definitive conclusions. Based on the limited available evidence, laser therapy may show a higher degree of re-osseointegration of implants than mechanical debridement.
(キーワード): Animals / Dental Implants / Osseointegration / Peri-Implantitis / Lasers / Photochemotherapy
(徳島大学機関リポジトリ): ● Metadata: 118749
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10103-023-03860-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37658921; ● Search Scopus @ Elsevier (PMID): 37658921; ● Search Scopus @ Elsevier (DOI): 10.1007/s10103-023-03860-9

(徳島大学機関リポジトリ: 118749, DOI: 10.1007/s10103-023-03860-9, PubMed: 37658921) 田中茉里子, 堀内信也, 日浅雅博, 渡邉佳一郎, 岩浅亮彦, 髙丸菜都美, 永井宏和, 宮本洋二, 田中栄二 :
術後に顎関節に疼痛を訴えた顎偏位を伴う骨格性上顎前突症例,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 77-86, 2023年. 花輪茂己, 日浅雅博, 岩浅亮彦, 渡邉佳一郎, 天眞寛文, 木内奈央, 堀内信也, 田中栄二 :
上顎左側第二小臼歯先天欠如を伴う片側性唇顎口蓋裂患者に対して下顎左側第二小臼歯を移植した一症例．,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 67-76, 2023年.

(キーワード): 中・四国矯正歯科学会雑誌 35(1):67-76.

Keiichiro Watanabe, A Tichy, Kouhei Kamoi, Masahiro Hiasa, Kazuhide Yonekura, Eiji Tanaka, M Nakajima and Keiichi Hosaka :
Restoration of a Microdont Using the Resin Composite Injection Technique With a Fully Digital Workflow: A Flexible 3D-printed Index With a Holding Clip.,
Operative Dentistry, 2023.

(要約): Direct composite restorations are accepted as a treatment option for microdontia, which is a relatively prevalent condition that poses esthetic concerns. While free-hand composite placement is technique-sensitive and time-consuming, the resin composite injection technique is more straightforward and predictable. A fully digital workflow has been recently introduced, but the 3D-printed resin index is rigid and challenged by undercuts, as opposed to the silicone index. This case report presents a flexible 3D-printed resin index, which can accurately transfer the digitally simulated functional and esthetic form to the final restoration. In addition, a rigid holding clip was designed to stabilize the flexible index.
(出版サイトへのリンク): ● Publication site (DOI): 10.2341/23-007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37503684; ● Search Scopus @ Elsevier (PMID): 37503684; ● Search Scopus @ Elsevier (DOI): 10.2341/23-007

(DOI: 10.2341/23-007, PubMed: 37503684) Ryoko Shioyasono, Atsushi Shioyasono, Ayami Ito, Kaoru Yoshinaga, Soichiro Kinjo, Keiichiro Watanabe, Masahiro Hiasa, Natsumi Takamaru and Eiji Tanaka :
A patient with unilateral posterior crossbite treated with modified unilateral surgically-assisted rapid maxillary expansion.,
AJO-DO Clinical Companion, Vol.3, No.2, 149-162, 2023.

(徳島大学機関リポジトリ): ● Metadata: 119697
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.xaor.2023.02.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.xaor.2023.02.001

(徳島大学機関リポジトリ: 119697, DOI: 10.1016/j.xaor.2023.02.001) Emiko Nakaue, Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Takeshi Harada, Asuka Oda, Yusuke Inoue, Sou Shimizu, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Eiji Tanaka and Masahiro Abe :
Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors.,
International Journal of Hematology, 2023.

(要約): Proteasome inhibitors (PIs) can preferentially restore bone in bone-defective lesions of patients with multiple myeloma (MM) who respond favorably to these drugs. Most prior in vitro studies on PIs used continuous exposure to low PI concentrations, although pharmacokinetic analysis in patients has shown that serum concentrations of PIs change in a pulsatile manner. In the present study, we explored the effects of pulsatile treatment with PIs on bone metabolism to simulate in vivo PI pharmacokinetics. Pulsatile treatment with bortezomib, carfilzomib, or ixazomib induced MM cell death but only marginally affected the viability of osteoclasts (OCs) with F-actin ring formation. Pulsatile PI treatment suppressed osteoclastogenesis in OC precursors and bone resorption by mature OCs. OCs robustly enhanced osteoblastogenesis in cocultures with OCs and MC3T3-E1 pre-osteoblastic cells, indicating OC-mediated coupling to osteoblastogenesis. Importantly, pulsatile PI treatment did not impair robust OC-mediated osteoblastogenesis. These results suggest that PIs might sufficiently reduce MM cell-derived osteoblastogenesis inhibitors to permit OC-driven bone formation coupling while suppressing OC differentiation and activity in good responders to PIs. OC-mediated coupling to osteoblastogenesis appears to be a predominant mechanism for preferential occurrence of bone regeneration at sites of osteoclastic bone destruction in good responders.
(徳島大学機関リポジトリ): ● Metadata: 118380
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12185-023-03601-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37039914; ● Search Scopus @ Elsevier (PMID): 37039914; ● Search Scopus @ Elsevier (DOI): 10.1007/s12185-023-03601-2

(徳島大学機関リポジトリ: 118380, DOI: 10.1007/s12185-023-03601-2, PubMed: 37039914) Ryoko Shioyasono, Kaoru Yoshinaga, Atsushi Shioyasono, Ayami Ito, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka :
Nonsurgical orthodontic treatment for a patient with Sotos syndrome.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.163, No.3, 426-442, 2023.

(要約): Sotos syndrome is a genetic disorder characterized by overgrowth in childhood, specific facial manifestations, advanced bone age, and mental retardation. The purpose of this article is to describe the nonsurgical orthodontic treatment of a 10-year-old boy with a skeletal mandibular protrusion, unilateral posterior crossbite, and Sotos syndrome. After maxillary lateral expansion, the skeletal Class III relationship with an anterior crossbite improved because of mandibular clockwise rotation, whereas the facemask had a marginal effect. After growth at 16 years, he had a skeletal Class I relationship, and thus, conventional orthodontic treatment with preadjusted edgewise appliances was initiated. After 41 months of multibracket treatment, acceptable occlusion with a functional Class I relationship was obtained. One year postretention, few changes in occlusion and facial features were observed. Our results demonstrate that considering the maxillofacial vertical growth during the peripubertal period associated with Sotos syndrome, more attention should be paid to the early orthopedic treatment with the facemask and/or chincap.
(キーワード): 男性 (male) / Humans / 子ども (children) / Malocclusion, Angle Class III / Sotos Syndrome / Cephalometry / Malocclusion / Mandible / Palatal Expansion Technique / Extraoral Traction Appliances / Maxilla
(徳島大学機関リポジトリ): ● Metadata: 118746
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2021.11.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36437146; ● CiNii @ 国立情報学研究所 (CRID): 1871991017445518080; ● Summary page in Scopus @ Elsevier: 2-s2.0-85142425693

(徳島大学機関リポジトリ: 118746, DOI: 10.1016/j.ajodo.2021.11.021, PubMed: 36437146, CiNii: 1871991017445518080, Elsevier: Scopus) 篠原丈裕, 岩浅亮彦, 栗林恭子, 坂巻拓馬, 田中栄二 :
過大なポステリアディスクレパンシーと前歯部の反対咬合を伴う骨格性Ⅰ級叢生の一治験例 -長期保定症例-,
Journal of Oral Health and Biosciences, Vol.35, No.2, 94-104, 2023年.

(要約): To clarify the characteristics of oral dysfunction in pediatric patients with malocclusion, we compared oral function between individuals with normal occlusion and those with malocclusion.A total of 108 participants, including 41 boys and 67 girls (mean age ± standard deviation, 9.4 ± 2.2 years), were recruited from outpatients who visited the Departments of Orthodontics and Pediatric Dentistry of Tokushima University Hospital. They were classified according to their occlusal status into normal occlusion, crowding, maxillary protrusion, mandibular protrusion, open bite, and others.This study revealed that patients with malocclusion had more functional problems (e.g. tongue thrust, low tongue posture and another oral habits) than subjects with normal occlusion and that the functional problems were associated with various types of malocclusion. Especially, patients with open bite showed the characteristic features of oral function and their maximum lip closure force was significantly weaker than that of subjects with normal occlusion (p < 0.05).We found the characteristic features of oral dysfunction in each malocclusion. It is thought that it is necessary to make an individual training program to the characteristic feature of oral function.
(キーワード): 口腔機能異常 / 不正咬合 / 矯正歯科治療 / 口腔筋機能療法
(徳島大学機関リポジトリ): ● Metadata: 118172
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.35.2_94
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390014093884089344; ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.2_94

(徳島大学機関リポジトリ: 118172, DOI: 10.20738/johb.35.2_94, CiNii: 1390014093884089344) Toyoaki Takagi and Eiji Tanaka :
An adult case of unilateral posterior crossbite caused by maxillary transverse deficiency treated with miniscrew-assisted rapid palatal expansion.,
Journal of Stomatology, Oral and Maxillofacial Surgery, Vol.124, No.6, 101443, 2023.

(要約): This report describes the successful treatment of an adult case of unilateral posterior crossbite caused by maxillary transverse deficiency with miniscrew-assisted rapid palatal expansion (MARPE). A female patient aged 35.5 years presented with masticatory disturbance, facial asymmetry, and unilateral posterior crossbite. She was diagnosed with unilateral posterior crossbite with a skeletal Class III jaw-base relationship and high mandibular plane angle. Her maxillary right and mandibular bilateral second premolars were congenitally absent, and the maxillary left second premolar was impacted. After the improvement of the posterior crossbite with MARPE, 0.018'' slot lingual brackets were placed on the maxillary and mandibular dentition. The total active treatment period was 22 months, and acceptable occlusion with a functional Class I relationship was achieved. Pretreatment and posttreatment cone-beam computed tomography images showed the disarticulation of the midpalatal suture after MARPE, and changes in the dental and nasomaxillary structures, nasal cavity, and pharyngeal airway. The case results demonstrate that MARPE produces greater skeletal expansion with minimal buccal tipping of the molars. MARPE may be effective for the treatment of maxillary transverse deficiency in adult patients.
(徳島大学機関リポジトリ): ● Metadata: 118748
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jormas.2023.101443
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36933657; ● CiNii @ 国立情報学研究所 (CRID): 1871709542830041472; ● Summary page in Scopus @ Elsevier: 2-s2.0-85169029960

(徳島大学機関リポジトリ: 118748, DOI: 10.1016/j.jormas.2023.101443, PubMed: 36933657, CiNii: 1871709542830041472, Elsevier: Scopus) Linze XIA, Fumiya Kano, Noboru Hashimoto, Cheng DING, Yang XU, Hideharu HIBI, Tomonori Iwasaki, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium from Stem Cells of Human Exfoliated Deciduous Teeth Partially Alters the Expression of Inflammation-associated Molecules of Mouse Condylar Chondrocytes via Secreted Frizzled-related Protein 1,
Journal of Oral Health and Biosciences, Vol.35, No.2, 52-60, 2023.

(徳島大学機関リポジトリ): ● Metadata: 118150
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.35.2_52
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.2_52

(徳島大学機関リポジトリ: 118150, DOI: 10.20738/johb.35.2_52) Kaoru Yoshinaga, Akihiro Yasue, Silvia Naomi Mitsui Akagi, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto and Eiji Tanaka :
Double Mutations on Tooth Development.,
Genes, Vol.14, No.2, 2023.

(要約): and that the interaction between the two genes functions in conjunction with other ligands to control the spatial patterning and development of teeth.
(キーワード): Animals / Humans / ノックアウトマウス (knockout mice) / 細胞増殖·分化 (cell proliferation and differentiation) / Mutation / Nerve Tissue Proteins / Odontogenesis / Phenotype / Proto-Oncogene Proteins / Tooth / Wnt Proteins
(徳島大学機関リポジトリ): ● Metadata: 118370
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/genes14020340
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36833267; ● Search Scopus @ Elsevier (PMID): 36833267; ● Search Scopus @ Elsevier (DOI): 10.3390/genes14020340

(徳島大学機関リポジトリ: 118370, DOI: 10.3390/genes14020340, PubMed: 36833267) Masaki Sawada, Saya Suetake, Hiroshi Yamada, Masaaki Higashino, Susumu Abe and Eiji Tanaka :
Orthodontic Treatment Does Not Affect Frontal Sinus Development in Female Adults: A Clinical Study,
Journal of Clinical Medicine, Vol.12, No.3, 778, 2023.

(要約): Frontal sinus growth is gradual and lasts until post-puberty. However, the influence of biomechanical stimuli, such as orthodontic treatment, on frontal sinus development after the growth period has ended remains unclear. This study was designed to elucidate the impact of orthodontic treatment on the frontal sinus morphology of adult females. Sixty women were included and divided into three groups, based on the Frankfort mandibular plane angle. All participants underwent computed tomography and lateral cephalometry before and after treatment. Although two participants exhibited frontal sinus agenesis, most exhibited a bilaterally symmetric frontal sinus without fusion. The frontal sinus width and height were almost similar, irrespective of the vertical skeletal pattern, where the frontal sinus depth was significantly larger in the average mandibular plane angle group than in the low- and high-angle groups. Furthermore, the sinus volume in the low-angle group was likely smaller than that in the average and high-angle groups. On comparing pre-treatment and post-treatment measurements, minimal or no changes to the frontal sinus dimension were detected after treatment. In conclusion, orthodontic treatment did not affect frontal sinus development after the end of growth.
(徳島大学機関リポジトリ): ● Metadata: 117920
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm12030778
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36769427; ● Summary page in Scopus @ Elsevier: 2-s2.0-85147811993

(徳島大学機関リポジトリ: 117920, DOI: 10.3390/jcm12030778, PubMed: 36769427, Elsevier: Scopus) Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, Sooha Kim, Motosumi Nakagawa, Sou Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2.,
Antioxidants, Vol.12, No.1, 2023.

(要約): Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical inducer of antioxidants, which is bound and repressed by a kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm. The Keap1-Nrf2 axis appears to be a major mechanism for robust inducible antioxidant defenses. Here, we demonstrate that febuxostat, a xanthine oxidase inhibitor, alleviates the increase in adipose tissue mass in obese mouse models with a high-fat diet or ovariectomy. Febuxostat disrupts in vitro adipocytic differentiation in adipogenic media. Adipocytes appeared at day 7 in absence or presence of febuxostat were 160.8 ± 21.2 vs. 52.5 ± 12.7 (p < 0.01) in 3T3L1 cells, and 126.0 ± 18.7 vs. 55.3 ± 13.4 (p < 0.01) in 10T1/2 cells, respectively. Adipocyte differentiation was further enhanced by the addition of hydrogen peroxide, which was also suppressed by febuxostat. Interestingly, febuxostat, but not allopurinol (another xanthine oxidase inhibitor), rapidly induced the nuclear translocation of Nrf2 and facilitated the degradation of Keap1, similar to the electrophilic Nrf2 activator omaveloxolone. These results suggest that febuxostat alleviates adipogenesis under oxidative conditions, at least in part by suppressing ROS production and Nrf2 activation. Regulation of adipocytic differentiation by febuxostat is expected to inhibit obesity due to menopause or overeating.
(徳島大学機関リポジトリ): ● Metadata: 118313
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/antiox12010133
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36670994; ● Search Scopus @ Elsevier (PMID): 36670994; ● Search Scopus @ Elsevier (DOI): 10.3390/antiox12010133

(徳島大学機関リポジトリ: 118313, DOI: 10.3390/antiox12010133, PubMed: 36670994) Joshua M. Ferraro, Sanghee Lee, Keiichiro Watanabe, Tai-Hsien Wu, Do-Gyoon Kim, Ching-Chang Ko, Eiji Tanaka, Motoyoshi Mitsuru and Toru Deguchi :
Accuracy of three-dimensional printed models derived from cone-beam computed tomography,
The Angle Orthodontist, Vol.92, No.6, 722-727, 2022.

(要約): To determine the accuracy of three-dimensional (3D) printed models fabricated from cone-beam computed tomography (CBCT) scans of human mandibular dry skulls in comparison with models derived from intraoral scanner (IOS) data. Six human mandibular dry skulls were scanned by IOS and CBCT. Digital models (DMs) constructed from the IOS and CBCT data were fabricated physically using a 3D printer. The width and thickness of individual teeth and intercanine and molar widths were measured using a digital caliper. The accuracy of the DMs was compared between IOS and CBCT. Paired t-tests were used for intergroup comparisons. All intraclass correlation coefficient values for the three measurements (mesial-distal, buccal-lingual, width) exceeded 0.9. For the mandibular teeth, there were significant discrepancies in model accuracy between the IOS (average discrepancies of 0.18 ± 0.08 mm and 0.16 ± 0.12 mm for width and thickness, respectively) and CBCT (0.28 ± 0.07 mm for width, 0.37 ± 0.2 mm for thickness; P < .01). Intercanine (P = .38) and molar widths (P = .41) showed no significant difference between groups. There was a statistically significant difference in the accuracy of DMs obtained from CBCT and IOS; however, this did not seem to result in any important clinical difference. CBCT could be routinely used as an orthodontic diagnostic tool and for appliance construction.
(キーワード): 3D printed model / CBCT
(徳島大学機関リポジトリ): ● Metadata: 117664
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/021122-128.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35852459; ● Search Scopus @ Elsevier (PMID): 35852459; ● Search Scopus @ Elsevier (DOI): 10.2319/021122-128.1

(徳島大学機関リポジトリ: 117664, DOI: 10.2319/021122-128.1, PubMed: 35852459) Susumu Abe, Fumiaki Kawano, Yoshizo Matsuka, Taeko Masuda, Toshinori Okawa and Eiji Tanaka :
Relationship between oral parafunctional and postural habits and the symptoms of temporomandibular disorders: A survey-based cross-sectional cohort study using propensity score matching analysis,
Journal of Clinical Medicine, Vol.11, No.21, 6396, 2022.

(要約): Temporomandibular disorders (TMDs) are a multifactorial joint disease of the masticatory system. The possible etiological factors involved in the onset and progression of TMDs include oral parafunctional habits (OPFHs) and postural habits (PHs). However, little information is available on the association between OPFHs and PHs and a predisposition to TMDs. Thus, to investigate whether the presence of OPFH and PH predisposes individuals to TMDs, a survey-based cross-sectional cohort study of self-reported TMD was performed. A total of 2292 patients with TMD were recruited for the survey. Through one-to-one propensity score matching, 166 patients with and without sleep bruxism (SB) were selected. The SB group had a significantly higher risk of masticatory muscular pain or fatigue than the non-SB group ( = 0.018). Furthermore, the SB group without other OFPHs and PHs did not show a significantly higher risk of TMD symptoms than the non-SB group. Diurnal clenching and bad posture also affect the stomatognathic system, causing pain or fatigue; however, it did not result in TMDs in patients without any OPFHs and PHs. This implies that OPFHs and PHs may increase the risk of TMD symptoms in coexistence with other habits.
(徳島大学機関リポジトリ): ● Metadata: 118895
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm11216396
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36362625; ● Search Scopus @ Elsevier (PMID): 36362625; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm11216396

(徳島大学機関リポジトリ: 118895, DOI: 10.3390/jcm11216396, PubMed: 36362625) Masaaki Higashino, Susumu Abe, Masaki Sawada, Hiroshi Yamada, Yusuke Ayani, Shin-Ichi Haginomori, Ryo Kawata, Toshihiro Matsuoka, Go Nakai, Keigo Osuga and Eiji Tanaka :
Development of the Sphenoid Sinus in Japanese Children: A Retrospective Longitudinal Study Using Three-Dimensional Computed Tomography,
Journal of Clinical Medicine, Vol.11, No.21, 6311, 2022.

(要約): The sphenoid sinus (SS) is located close to vital structures, such as the pituitary gland, and it has significant clinical relevance. This study aimed to clarify the growth pattern of the SS in Japanese children using three-dimensional computed tomography (CT). Seventy-eight participants with congenital, acquired, or external auditory canal cholesteatoma were recruited and underwent CT more than twice during their treatment. Using the volume-rendered images, the size and volume of the SS were measured. Furthermore, on the scout image, the morphological measurements of the cranial base were determined. The size and volume of the SS increased with age, and peaked at the mean age of 15 years. For males, the volume of the SS was smaller than that of females aged <5 years. The growth rate of the SS was significantly higher in males than in females. The maximum growth rate was detected at the age of 12 years for males and 10 years for females. For females, the increase in the length of the anterior cranial base ceased at approximately 10 years of age and remained constant thereafter. In contrast, for males, the length of the anterior cranial base increased gradually until 15 years of age. Considering the similarity of the periods between the adolescent growth spurt and the maximum growth rate of the SS, changes in the size of the SS may be used as an indicator of the physical growth spurt.
(徳島大学機関リポジトリ): ● Metadata: 118025
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm11216311
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36362538; ● Search Scopus @ Elsevier (PMID): 36362538; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm11216311

(徳島大学機関リポジトリ: 118025, DOI: 10.3390/jcm11216311, PubMed: 36362538) 日浅早紀, 川合暢彦, 堀内信也, 田中栄二, 伊賀弘起 :
小児不正咬合患者の小児患者における口腔機能障害の特徴,
Journal of Oral Health and Biosciences, Vol.35, No.1, 1-8, 2022年.

(要約): To clarify the characteristics of oral dysfunction in pediatric patients with malocclusion, we compared oral function between individuals with normal occlusion and those with malocclusion.A total of 108 participants, including 41 boys and 67 girls (mean age ± standard deviation, 9.4 ± 2.2 years), were recruited from outpatients who visited the Departments of Orthodontics and Pediatric Dentistry of Tokushima University Hospital. They were classified according to their occlusal status into normal occlusion, crowding, maxillary protrusion, mandibular protrusion, open bite, and others.This study revealed that patients with malocclusion had more functional problems (e.g. tongue thrust, low tongue posture and another oral habits) than subjects with normal occlusion and that the functional problems were associated with various types of malocclusion. Especially, patients with open bite showed the characteristic features of oral function and their maximum lip closure force was significantly weaker than that of subjects with normal occlusion (p < 0.05).We found the characteristic features of oral dysfunction in each malocclusion. It is thought that it is necessary to make an individual training program to the characteristic feature of oral function.
(キーワード): 口腔機能異常 / 不正咬合 / 矯正歯科治療 / 口腔筋機能療法
(徳島大学機関リポジトリ): ● Metadata: 117476
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.35.1_1
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_1

(徳島大学機関リポジトリ: 117476, DOI: 10.20738/johb.35.1_1) 髙橋史子, 日浅雅博, 堀内信也, 田中栄二 :
矯正歯科治療の経過予後からみた埋伏下顎大臼歯の歯科用CB-CT画像の特徴と牽引可否との関連性,
中·四国矯正歯科学会雑誌, Vol.34, No.1, 75-82, 2022年.

(要約): 【目的】埋伏下顎大臼歯は，発生率は低いものの骨性癒着が認められた際は重大な不正咬合の原因となる．その治療予後の予測は未だ困難であり，重要な臨床課題の一つである．本研究では臨床的に牽引が不可能であった下顎大臼歯のエックス線画像を見直し，牽引可能であった例と比較することで，牽引の可否を鑑別するための特徴的な画像所見を検討した．【方法】資料として徳島大学病院矯正歯科を受診した第三大臼歯を除く下顎大臼歯の埋伏を有する患者5 名の歯科用コーンビームCT (以下CB-CT) 画像とパノラマエックス線画像を用いた．Ducommun らの骨性癒着歯の評価項目である歯根膜腔消失・歯根吸収・組織置換に加え，置換性歯根吸収(歯根吸収により生じた歯根表面の凹凸部の骨硬化像)，歯根彎曲の有無を評価した．【結果】パノラマエックス線画像では5 例全てで歯根膜腔の消失を認めたが，歯根吸収や組織置換像は観察されなかった．一方，CB-CT 画像では牽引が不可能であった3 例全てで歯根膜腔の消失と置換性歯根吸収像を認めた．牽引が可能であった2 例でも歯根膜腔の消失がみられ，うち1 例では歯根吸収像も認めたがその近傍に骨硬化像はなかった．【考察】Ducommun らの評価項目のみでは，牽引可能であった1 例が偽陽性となったが，置換性歯根吸収の評価項目への追加により偽陽性はなくなった．このことから置換性歯根吸収の評価が埋伏下顎大臼歯の牽引の可否の鑑別に極めて重要であると考えられた．【結論】埋伏下顎大臼歯の診断において，CB-CT 画像での当該歯の周囲組織の詳細な観察により，牽引が可能であるかを非常に高い精度で診断できる可能性が示唆された．
(キーワード): 骨性癒着歯 / コーンビームCT
(徳島大学機関リポジトリ): ● Metadata: 118828

(徳島大学機関リポジトリ: 118828) 重田南, 渡邉佳一郎, 森浩喜, 田中栄二 :
犬歯の埋伏による重度歯根吸収を呈した上顎切歯に対して下顎小臼歯の自家移植を行った歯性上顎前突の一治験例,
中·四国矯正歯科学会雑誌, Vol.34, No.1, 53-64, 2022年.

(徳島大学機関リポジトリ): ● Metadata: 118827

(徳島大学機関リポジトリ: 118827) Masahiko Watanabe, Nobuhiko Kawai, Manami Shibata, Emiko Nakaue, Shinya Horiuchi and Eiji Tanaka :
Establishment of a new rehabilitation program using masticatory training food for jaw deformity patients.,
Journal of Dental Sciences, Vol.17, No.3, 1217-1224, 2022.

(要約): Compared with the non-training group, the training group showed a trend toward greater recovery amount of MBF from Pre to T3, and a significantly greater recovery amount in MP (p < 0.05) from Pre to T3. When the time-series change of MP was evaluated in both groups from T0 to T3, a significant difference was observed in the interaction terms (p = 0.03). This result indicates that the effectiveness of the training may be demonstrated by following the postoperative course further.
(徳島大学機関リポジトリ): ● Metadata: 117259
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jds.2021.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35784158; ● Search Scopus @ Elsevier (PMID): 35784158; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jds.2021.12.007

(徳島大学機関リポジトリ: 117259, DOI: 10.1016/j.jds.2021.12.007, PubMed: 35784158) Takuma Sakamaki, Keiichiro Watanabe, Akihiko Iwasa, Toru Deguchi, Shinya Horiuchi and Eiji Tanaka :
Thread shape, cortical bone thickness, and magnitude and distribution of stress caused by the loading of orthodontic miniscrews: finite element analysis.,
Scientific Reports, Vol.12, No.1, 2022.

(要約): Cortical bone thickness is assumed to be a major factor regulating miniscrew stability. We investigated stress distribution in two miniscrews with different thread shapes (type A and B) and in cortical bone of three different thicknesses using three-dimensional (3D) finite element (FE) models. More specifically, 3D FE models of two different miniscrews were created and placed obliquely or vertically into a cylindrical bone model representing different cortical bone thicknesses. When force was applied to the miniscrew, the stress distribution on the screw surface and in the peri-implant bone was assessed using FE methodology. Miniscrew safety was evaluated using a modified Soderberg safety factor. Screw head displacement increased with a decrease in cortical bone thickness, irrespective of screw type. The smallest minimum principal stresses on the screw surfaces remained constant in type A miniscrews on changes in cortical bone thickness. Minimum principal stresses also appeared on the cortical bone surface. Lower absolute values of minimum principal stresses were seen in type A miniscrews when placed vertically and with upward traction in obliquely placed type B miniscrews. Both miniscrews had acceptable safety factor values. Taken together, orthodontists should select and use the suitable miniscrew for each patient in consideration of bone properties.
(キーワード): Cortical Bone / 有限要素解析 (finite element analysis) / Humans / Orthodontic Anchorage Procedures / Orthodontic Appliance Design / Stress, Mechanical / チタン (titanium)
(徳島大学機関リポジトリ): ● Metadata: 117262
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-022-16662-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35859046; ● Search Scopus @ Elsevier (PMID): 35859046; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-16662-w

(徳島大学機関リポジトリ: 117262, DOI: 10.1038/s41598-022-16662-w, PubMed: 35859046) Sou Shimizu, Jumpei Teramachi, Takeshi Harada, Masahiro Hiasa, Hirofumi Tenshin, A Oda, A Seki, Y Inoue, Kotaro Tanimoto, Yoshiki Higa, M Oura, K Sogabe, Takeshi Harada, Ryohei Sumitani, T Maruhashi, H Yamagami, Y Sawa, Itsuro Endo, K Tsuneyama, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
Aberrant upregulation of the endogenous PP2A inhibitor CIP2A is vital for myeloma cell growth and survival,
International Journal of Myeloma, Vol.12, No.2, 14-23, 2022.

(要約): The serine/threonine kinase TAK1 is constitutively overexpressed and auto-phosphorylated in multiple myeloma (MM) cells. Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase which dephosphorylates proteins phosphorylated by various serine/threonine kinases to regulate multiple cellular functions. We recently reported that the serine/threonine kinase TGF-β-activated kinase-1 (TAK1) is highly expressed and auto-phosphorylated to mediate critical growth and survival signaling in MM cells. We demonstrate here that regulation of PP2A activity inversely affects the phosphorylation levels of TAK1 in MM cells, and that MM cells aberrantly overexpress cancerous inhibitor of PP2A (CIP2A), an endogenous inhibitor for PP2A. CIP2A gene silencing as well as treatment with the CIP2A inhibitor TD52 potently induced MM cell death along with suppression of TAK1 expression in MM cells. These results suggest the critical role of PP2A inactivation via CIP2A upregulation in TAK1 phosphorylation and its protein expression and thereby MM cell growth and survival, posing the CIP2A-PP2A axis as an important therapeutic target.
(キーワード): multiple myeloma / TAK1 / CIP2A / PP2A (PP2A)
(徳島大学機関リポジトリ): ● Metadata: 117150
(出版サイトへのリンク): ● Publication site (DOI): 10.57352/ijm.12.2_14
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390573947533793024; ● Search Scopus @ Elsevier (DOI): 10.57352/ijm.12.2_14

(徳島大学機関リポジトリ: 117150, DOI: 10.57352/ijm.12.2_14, CiNii: 1390573947533793024) Masaki Sawada, Hiroshi Yamada, Masaaki Higashino, Susumu Abe and Eiji Tanaka :
Volumetric Assessment of the Frontal Sinus in Female Adolescents and Its Relationship with Craniofacial Morphology and Orthodontic Treatment: A Pilot Study,
International Journal of Environmental Research and Public Health, Vol.19, No.12, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117316
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijerph19127287
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/ijerph19127287

(徳島大学機関リポジトリ: 117316, DOI: 10.3390/ijerph19127287) Keiichiro Watanabe, Bobby Mitchell, Takuma Sakamaki, Yuzo Hirai, Do-Gyoon Kim, Toru Deguchi, Masakazu Suzuki, Kanji Ueda and Eiji Tanaka :
Mechanical stability of orthodontic miniscrew depends on a thread shape.,
Journal of Dental Sciences, Vol.17, No.3, 1244-1252, 2022.

(要約): The MIT, RT, TR and K of type C miniscrew were significantly greater than those of type A and B miniscrews when the miniscrews were placed in the thinner artificial bone. Furthermore, the TR value of type C miniscrew was more than 1, indicating the MRT value was larger than the MIT value in the novel miniscrew. The values of K∗ and tan
(徳島大学機関リポジトリ): ● Metadata: 117257
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jds.2021.11.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35784157; ● Search Scopus @ Elsevier (PMID): 35784157; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jds.2021.11.010

(徳島大学機関リポジトリ: 117257, DOI: 10.1016/j.jds.2021.11.010, PubMed: 35784157) Islamy Rahma Hutami, Takashi Izawa, Tsendsuren Khurel-Ochir, Takuma Sakamaki, Akihiko Iwasa, Shuhei Tomita and Eiji Tanaka :
HIF-1α controls palatal wound healing by regulating macrophage motility via S1P/S1P1 signaling axis.,
Oral Diseases, Vol.28, No.4, 1157-1169, 2022.

(要約): signaling. These results suggest that HIF-1α signaling may contribute to the regulation of palatal wound healing.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/odi.13856
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33759275; ● Search Scopus @ Elsevier (PMID): 33759275; ● Search Scopus @ Elsevier (DOI): 10.1111/odi.13856

(DOI: 10.1111/odi.13856, PubMed: 33759275) Yuta Matsuki, Hiroko Sato, N Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada :
Effect of immersion in NaCl solution on the electrical conductivity and the reduction of the shear bond strength of resin-modifi ed glass-ionomer-cements after current application,
Dental Materials Journal, Vol.41, No.3, 487-494, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117038
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.2021-322
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35264547; ● Search Scopus @ Elsevier (PMID): 35264547; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2021-322

(徳島大学機関リポジトリ: 117038, DOI: 10.4012/dmj.2021-322, PubMed: 35264547) Toyoaki Takagi, Sou Shimizu and Eiji Tanaka :
Alveolar corticotomy for extrusion of an ankylosed lower first molar.,
Journal of Clinical Orthodontics, Vol.56, No.5, 299-307, 2022.

(キーワード): Humans / Molar / Tooth Ankylosis / Tooth Movement Techniques
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35767859; ● Search Scopus @ Elsevier (PMID): 35767859

(PubMed: 35767859) Nobuhiko Kawai, Masahiko Watanabe, Manami Shibata, Shinya Horiuchi, Kenji Fushima and Eiji Tanaka :
Treatment decision of camouflage or surgical orthodontic treatment for skeletal Class III patients based on analysis of masticatory function.,
Journal of Dental Sciences, Vol.17, No.2, 822-830, 2022.

(要約): Camouflage orthodontic treatment is inappropriate for patients with relatively severe dentoskeletal discrepancies. Wits appraisal of -6.0 mm is a potentially useful parameter for treatment decision.
(徳島大学機関リポジトリ): ● Metadata: 117256
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jds.2021.09.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35756806; ● Search Scopus @ Elsevier (PMID): 35756806; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jds.2021.09.036

(徳島大学機関リポジトリ: 117256, DOI: 10.1016/j.jds.2021.09.036, PubMed: 35756806) YAO LIU, Fumiya Kano, Noboru Hashimoto, LINZE XIA, Qiao Zhou, Xingmei Feng, Hideharu Hibi, Aya Miyazaki, Tsutomu Iwamoto, Yoshizo Matsuka, Zhijun Zhang, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model.,
Frontiers in Pharmacology, Vol.13, 745020, 2022.

(要約): In neuropathic pain (NP), injury or diseases of the somatosensory system often result in highly debilitating chronic pain. Currently, there is no effective drug for the complete and definitive treatment of NP. We investigated the therapeutic potential of conditioned medium (CM) derived from stem cells from human exfoliated deciduous teeth (SHED-CM) against NP using a mouse partial sciatic nerve ligation (PSL) model. Abnormal pain sensation, such as tactile allodynia and hyperalgesia, can be caused by PSL. In the behavioral test, intravenous administration of SHED-CM greatly improved the PSL-induced hypersensitivity. We found that treatment with SHED-CM resulted in the recruitment of M2 macrophages in the injured sciatic nerve and ipsilateral L4/L5 dorsal root ganglion and suppressed microglial activation in the spinal cord. Notably, specific depletion of the anti-inflammatory M2 macrophages by mannosylated-Clodrosome markedly reduced the antinociceptive effect of SHED-CM. Intravenous administration of CM from M2 induced by SHED-CM (M2-CM) ameliorated the PSL-induced hypersensitivity. We found that M2-CM directly suppressed the expression of nociceptive receptors as well as proinflammatory mediators in Schwann cells. Taken together, our data suggest that SHED-CM ameliorates NP through the induction of the analgesic anti-inflammatory M2 macrophages. Thus, SHED-CM may be a novel therapeutic candidate for NP.
(徳島大学機関リポジトリ): ● Metadata: 117219
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fphar.2022.745020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35431971; ● Summary page in Scopus @ Elsevier: 2-s2.0-85128452809

(徳島大学機関リポジトリ: 117219, DOI: 10.3389/fphar.2022.745020, PubMed: 35431971, Elsevier: Scopus) Akihiko Iwasa and Eiji Tanaka :
Signs, Symptoms, and Morphological Features of Idiopathic Condylar Resorption in Orthodontic Patients: A Survey-Based Study,
Journal of Clinical Medicine, Vol.11, No.6, 1552, 2022.

(要約): Idiopathic condylar resorption (ICR) is an aggressive degenerative disease of the temporomandibular joint that is most frequently observed in teenage girls. However, no specific cause of ICR has been identified. To explore the specific causes of the onset and progression of ICR, we performed a survey-based study on ICR in orthodontic patients and described its subjective symptoms, clinical signs, and condylar morphological features. A total of 1735 participants were recruited from 2193 orthodontic patients. For each participant, subjective symptoms and clinical signs of temporomandibular disorders (TMDs) were evaluated through clinical examination and a questionnaire. Furthermore, three-dimensional computed tomography (CT) was performed to diagnose ICR. Among the 1735 patients evaluated, ICR was present in two male and ten female patients. All 12 patients had maxillary protrusion and an anterior open bite. Four patients with ICR underwent orthodontic treatment. Based on CT findings, patients with ICR had significantly different condylar sizes and shapes from patients with TMDs alone. The coexistence of intrinsic and extrinsic factors, such as sex-hormone imbalance and a history of orthodontic treatment, might lead to the onset of ICR. We suggest that growing patients suspected of having ICR should undergo CT evaluation because CT findings may precede clinical symptoms and signs.
(徳島大学機関リポジトリ): ● Metadata: 117229
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm11061552
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35329876; ● Summary page in Scopus @ Elsevier: 2-s2.0-85126281580

(徳島大学機関リポジトリ: 117229, DOI: 10.3390/jcm11061552, PubMed: 35329876, Elsevier: Scopus) Muneyuki Yoshimura, Emi Takegawa, Kazumitsu Sekine, Shinya Horiuchi, Eiji Tanaka and Kenichi Hamada :
Volume Magnetic Susceptibility Estimation of α- and β-Phases in Titanium Alloys for Biomedical Applications.,
Journal of Oral Health and Biosciences, Vol.34, No.2, 34-39, 2022.

(要約): Metallic medical devices in the human body cause serious artifacts in magnetic resonance imaging owing to the volume magnetic susceptibility (χν) mismatch between the device and tissue around the device. To reduce artifacts, medical devices produced from alloys with χν values of approximately -9 × 10-6 are required. Controlling the phase constitution is a basic technique used to control the χν value of an alloy, and the χν value of each phase is a fundamental property. In this study, an α+β-type Ti alloy and two β-type Ti alloys were investigated. The estimated χν values of the α-phase of the alloys were similar to or smaller than that of pure Ti. In contrast, the estimated χν values of the β-phase of the alloys were larger than that of pure Ti. Since the χν value of pure Ti is much larger than -9 × 10-6, the χν values of the β-phases suggested that increasing the volume fraction of the β-phase was not appropriate for producing a Ti alloy with a lower χν value.
(キーワード): Volume magnetic susceptibility / Phase constitution / Heat treatment / Ti-6Al-4V alloy / Ti-Mo alloy
(徳島大学機関リポジトリ): ● Metadata: 116783
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.34.2_34
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.2_34

(徳島大学機関リポジトリ: 116783, DOI: 10.20738/johb.34.2_34) Daishi Arai, Akihiro Yasue, Shinya Horiuchi and Eiji Tanaka :
A Multidisciplinary Approach to Malocclusion Caused by Facial Multiple Fracture.,
Case Reports in Dentistry, Vol.2022, 2022.

(要約): In the case of multiple facial fractures, a simple open reduction occasionally causes various disorders during healing process after the surgery. Moreover, esthetic disturbance of a facial deformity might be induced. Therefore, the acquisition of facial symmetry and the recovery of occlusal and masticatory functions become increasingly important. This case report presents a successful treatment of facial multiple fracture induced by a car accident. A 20-year-old male was diagnosed with suffered multiple midface and mandibular fractures induced by a car accident. Midface fractures included the LeFort I and II type fractures, as well as sagittal fracture at midline and fractures from right maxillary sinus anterior wall to orbital wall. In the mandible, midline and left body fractures were detected. The patient underwent open reduction and rigid fixation of the fractured left zygoma, comminuted LeFort I and II fractures, and midline and left body of the mandible with intermaxillary fixation by multibracket appliance; maxillary osteotomy with iliac bone grafting; orthognathic two-jaw surgery with coronoid process grafts onto the depressed zygoma; and onlay graft of hydroxyapatite block on mandible. As the result, the multidisciplinary treatments successfully recover functions and esthetics to the satisfactory level of the patient with multiple facial fractures. As treatments for multiple facial fractures are required complexity due to the extent of trauma, multidisciplinary approach under the close cooperation between hospital departments is thought to be important.
(徳島大学機関リポジトリ): ● Metadata: 117261
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2022/5209667
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35284144; ● Search Scopus @ Elsevier (PMID): 35284144; ● Search Scopus @ Elsevier (DOI): 10.1155/2022/5209667

(徳島大学機関リポジトリ: 117261, DOI: 10.1155/2022/5209667, PubMed: 35284144) Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Takeshi Harada, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Tomoyo Hara, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
Mechanical unloading aggravates bone destruction and tumor expansion in myeloma.,
Haematologica, Vol.107, No.3, 744-749, 2022.

(キーワード): Bone Resorption / Humans / Multiple Myeloma / Osteoclasts / Osteolysis
(徳島大学機関リポジトリ): ● Metadata: 116715
(出版サイトへのリンク): ● Publication site (DOI): 10.3324/haematol.2021.278295
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34788982; ● Search Scopus @ Elsevier (PMID): 34788982; ● Search Scopus @ Elsevier (DOI): 10.3324/haematol.2021.278295

(徳島大学機関リポジトリ: 116715, DOI: 10.3324/haematol.2021.278295, PubMed: 34788982) Hirofumi Tenshin, Jumpei Teramachi, Mohannad Ashtar, Masahiro Hiasa, Yusuke Inoue, Asuka Oda, Kotaro Tanimoto, Sou Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
TGF-β-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-α and RANKL expression.,
Clinical & translational immunology, Vol.11, No.1, 2022.

(要約): TAK1 inhibition with LLZ may become a novel treatment strategy to effectively alleviate inflammasome-mediated inflammation and RANKL-induced osteoclastic bone destruction in joints alongside its potent suppression of TNF-α and IL-6 production and proteinase-mediated pathological processes in RA.
(徳島大学機関リポジトリ): ● Metadata: 117260
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cti2.1371
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35079379; ● Search Scopus @ Elsevier (PMID): 35079379; ● Search Scopus @ Elsevier (DOI): 10.1002/cti2.1371

(徳島大学機関リポジトリ: 117260, DOI: 10.1002/cti2.1371, PubMed: 35079379) 小作一仁, 中嶋昭, 西恭一, 納村泰弘, 一色祥智, 中村純基, 新井嘉則, 髙橋進, 田中栄二, 本橋満 :
トルクを付加した際の歯および歯根膜における応力分布の有限要素解析,
日大歯学, Vol.95, No.1, 29-35, 2021年.

(徳島大学機関リポジトリ): ● Metadata: 116280
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853835065315840

(徳島大学機関リポジトリ: 116280, CiNii: 1520853835065315840) 田中栄二 :
矯正歯科臨床における下顎頭吸収への対応,
北海道矯正歯科学会雑誌, Vol.49, No.1, 11-17, 2021年.

(キーワード): 特発性下顎頭吸収 / 変形性顎関節症 / 歯科矯正治療
(徳島大学機関リポジトリ): ● Metadata: 117558

(徳島大学機関リポジトリ: 117558) Hiroshi Yamada, Masaki Sawada, Masaaki Higashino, Susumu Abe, Tarek El-Bialy and Eiji Tanaka :
Longitudinal Morphological Changes in the Adenoids and Tonsils in Japanese School Children.,
Journal of Clinical Medicine, Vol.10, No.21, 2021.

(要約): The adenoid (Ad) and tonsil (Ts), located in the upper airway, play an important role in immunological protection. These lymphoid tissues grow rapidly, reach a peak of growth at the age of 6-8 years, and decrease in their size thereafter. However, little information is available on the longitudinal growth patterns of Ad and Ts in the general population. This study aimed to evaluate the individual growth of Ad and Ts during childhood using lateral cephalograms taken longitudinally from the same individuals at the ages of 8-12 years. Our results showed that the cross-sectional areas of the Ad, nasopharynx (Np), and oropharynx (Op) significantly increased with age while small changes in the size of Ts were present throughout the study period. In addition, the values of Ad/Np and Ts/Op decreased significantly with age in the elementary school. Furthermore, there was a strong and significant correlation between the Ad/Np ratio and upper airway resistance, indicating the narrowest distance in the upper airway. In conclusion, the airway occupation in Np and Op increased with age due to the increase in the sizes of Np and Op but not the decrease in the sizes of Ad and Ts.
(徳島大学機関リポジトリ): ● Metadata: 116743
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm10214956
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34768477; ● Summary page in Scopus @ Elsevier: 2-s2.0-85117922437

(徳島大学機関リポジトリ: 116743, DOI: 10.3390/jcm10214956, PubMed: 34768477, Elsevier: Scopus) Shinya Horiuchi, Hiroko Sato, Akihiko Iwasa, Aki Ichihara, Hirofumi Tenshin, Keiichiro Watanabe, Masahiro Hiasa, Ichiro Hashimoto and Eiji Tanaka :
Long-term Management of a Patient with Apert Syndrome.,
The Journal of Contemporary Dental Practice, Vol.22, No.10, 1184-1190, 2021.

(要約): The two-stage operation combining early distraction osteogenesis and postgrowth orthognathic surgery proves to be an effective therapy for correcting midfacial hypoplasia and skeletal mandibular protrusion caused by Apert syndrome.
(キーワード): Acrocephalosyndactylia / Adolescent / Adult / Cephalometry / Humans / Infant / Male / Open Bite / Osteogenesis, Distraction / Osteotomy, Le Fort / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 117255
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35197388; ● Search Scopus @ Elsevier (PMID): 35197388

(徳島大学機関リポジトリ: 117255, PubMed: 35197388) Yuzo Hirai, Keiichiro Watanabe, Toru Deguchi, Kanji Ueda, Kenichi Hamada and Eiji Tanaka :
Influence of insertion depth on stress distribution in orthodontic miniscrew and the surrounding bone by finite element analysis.,
Dental Materials Journal, Vol.40, No.5, 1270-1276, 2021.

(要約): We aimed to elucidate stress distribution in miniscrews and the surrounding bone when miniscrews inserted at different depths were implanted vertically or obliquely. The distributions of the equivalent stress on the screw surface and the minimum principal stress in the surrounding bone were calculated using finite element models. When the miniscrews were inserted vertically and obliquely, screw head displacement, greatest equivalent stress on the miniscrew surface, and absolute value of minimum principal stresses in the surrounding bone decreased with increasing insertion depth. Stresses in the obliquely inserted miniscrew with upward traction were smaller than in other insertion conditions, irrespective of insertion depth. With the application of orthodontic force, stress distribution around the miniscrew and surrounding bone is closely related to the insertion depth and insertion angle, which mutually affect each other. In particular, the obliquely inserted miniscrew with upward traction might be the most secure against screw failure and fracture.
(徳島大学機関リポジトリ): ● Metadata: 116714
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.2020-400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34193725; ● Search Scopus @ Elsevier (PMID): 34193725; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2020-400

(徳島大学機関リポジトリ: 116714, DOI: 10.4012/dmj.2020-400, PubMed: 34193725) Masahiro Hiasa, Takeshi Harada, Eiji Tanaka and Masahiro Abe :
Pathogenesis and treatment of multiple myeloma bone disease.,
Japanese Dental Science Review, Vol.57, 164-173, 2021.

(要約): Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succinctly summarize currently available therapeutic options and the development of novel bone modifying agents for myeloma treatment.
(徳島大学機関リポジトリ): ● Metadata: 117254
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jdsr.2021.08.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34611468; ● Search Scopus @ Elsevier (PMID): 34611468; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdsr.2021.08.006

(徳島大学機関リポジトリ: 117254, DOI: 10.1016/j.jdsr.2021.08.006, PubMed: 34611468) Yao Liu, Linze Xia, Fumiya Kano, Noboru Hashimoto, Yoshizo Matsuka, Akihito Yamamoto and Eiji Tanaka :
Low-intensity pulsed ultrasound ameliorates neuropathic pain induced by partial sciatic nerve ligation via regulating macrophage polarization,
Journal of Oral Health and Biosciences, Vol.34, 11-18, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116287
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.34.1_11
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390570784697431168; ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.1_11

(徳島大学機関リポジトリ: 116287, DOI: 10.20738/johb.34.1_11, CiNii: 1390570784697431168) Hiroshi Yamada, Masaki Sawada and Eiji Tanaka :
Treatment of hemifacial microsomia using conventional orthodontic techniques: Report of a case with long-term follow-up.,
The Journal of the American Dental Association, Vol.152, No.8, 653-668, 2021.

(要約): Early orthodontic management only can have some limitations but could be one of the treatment options for hemifacial microsomia.
(キーワード): Child / Facial Asymmetry / Female / Follow-Up Studies / Goldenhar Syndrome / Humans / Mandible / Tooth
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.adaj.2020.10.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33674034; ● Search Scopus @ Elsevier (PMID): 33674034; ● Search Scopus @ Elsevier (DOI): 10.1016/j.adaj.2020.10.015

(DOI: 10.1016/j.adaj.2020.10.015, PubMed: 33674034) Islamy Rahma Hutami, Takashi Izawa, Tsendsuren Khurel-Ochir, Takuma Sakamaki, Akihiko Iwasa and Eiji Tanaka :
Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling.,
International Journal of Molecular Sciences, Vol.22, No.16, 2021.

(要約): Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1α regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing.
(キーワード): Animals / Cell Differentiation / Cell Movement / Cytokines / Gene Expression / Gene Expression Regulation / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Inflammation / Lysophospholipids / Macrophage Activation / Macrophages / Phosphatidylinositol 3-Kinases / Signal Transduction / Sphingosine / Wound Healing
(徳島大学機関リポジトリ): ● Metadata: 117253
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms22168992
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34445695; ● Search Scopus @ Elsevier (PMID): 34445695; ● Search Scopus @ Elsevier (DOI): 10.3390/ijms22168992

(徳島大学機関リポジトリ: 117253, DOI: 10.3390/ijms22168992, PubMed: 34445695) 比嘉佳基, 泰江章博, 三井なおみ, 田中栄二 :
Temporary Anchorage Devices (TADs)を用い非抜歯遠心移動治療を行った長期安定2症例,
中·四国矯正歯科学会雑誌, Vol.33, No.1, 59-68, 2021年.

(要約): 今回，我々はTemporary Anchorage Devices(TADs)を用いて上下顎歯列全体の遠心移動による非抜歯治療を遂行し，保定後5年以上の経過時においても安定した咬合関係が維持された2症例を経験したので報告する．症例1は，初診時年齢29歳の女性で，開咬を主訴として来院した．口腔内所見は，overjet -1.0mm，overbite -1.0mmで，上下顎歯列正中の不一致を認めた．アーチレングスディスクレパンシーは上顎-0.5mm，下顎-2.0mmであり，臼歯関係は右側Angle I級，左側Angle III級であった．側面頭部エックス線規格写真分析の結果，∠ANB3.9°よりskeletal Class I，FMA33.6°よりhigh mandibular plane angleであり，口唇突出感のある前歯部開咬を伴う歯性上下顎前突と診断された．上顎両側臼歯部頬側歯槽部に歯科矯正用アンカースクリューを，下顎両側大臼歯部にアンカープレートを植立し，マルチブラケット装置を装着した後，歯列全体の遠心移動により咬合を確立した．症例2は，初診時年齢60歳の女性で，下顎前歯部の叢生を主訴として来院した．口腔内所見は，overjet +6.0mm，overbite +1.5mmで，アーチレングスディスクレパンシーは上顎-2.5mm，下顎-6.0mmであり，両側第一小臼歯は鋏状咬合を呈し，臼歯関係は両側Angle I級であった．側面頭部エックス線規格写真分析の結果，∠ANB4.4°よりskeletal Class I，FMA26.1°よりlow mandibular plane angleであり，口唇突出感のある叢生を伴う歯性上顎前突と診断された．上下顎両側臼歯部頬側歯槽部に歯科矯正用アンカースクリューを植立後，上下顎とも臼歯部の遠心移動を先行させ，前歯部の排列スペースを確保した後，上下顎歯列全体の遠心移動を行うことで咬合を確立した．TADsを固定源にマルチブラケット装置を用い，上下顎歯列全体の遠心移動による咬合確立を行った2症例であるが，それぞれ保定7年10ヵ月，5年7ヵ月経過後も安定した咬合が維持されていた．従来であれば抜歯治療の適用となる症例であったが，TADsを用いた歯列全体の遠心移動により非抜歯にて適切な咬合が獲得でき，長期的安定性も得られることが示唆された．(著者抄録)
(徳島大学機関リポジトリ): ● Metadata: 117950

(徳島大学機関リポジトリ: 117950) 吉永薫, 塩屋園玲子, 渡邉佳一郎, 日浅雅博, 堀内信也, 田中栄二 :
歯科矯正用アンカースクリューの導入に伴う治療方針の変化(第一報) 抜歯・非抜歯および抜歯部位の判定に関する検討,
中·四国矯正歯科学会雑誌, Vol.33, No.1, 19-28, 2021年.

(要約): 【目的】近年，歯科矯正用アンカースクリュー(以降アンカーと明記する)の普及により，臼歯の固定や移動が容易に行えるようになり，抜歯，非抜歯，抜歯部位の選択についても変化が起きている．今回，アンカーの導入前後での治療方針の変化について，とくに臼歯抜歯の適応に関する調査を行ったので報告する．【方法】徳島大学病院矯正歯科を受診した初診時年齢12歳以上の患者を対象とし，2002年以前にマルチブラケット治療の診断を受けた100名(Pre群)と2008年以降に診断を受けた100名(Post群)を無作為に抽出した．先天性疾患および歯牙欠損症例，顎変形症は除外した．診断内容における臼歯抜歯(第三大臼歯は除く)の有無，抜歯部位等に関する比較検討を行った．【結果および考察】Pre群とPost群の間で抜歯症例数および抜歯部位に違いは認められなかった．一方，skeletal Class IIの症例はPre群では上顎片顎小臼歯抜歯によるカムフラージュ治療が多かったのに対し，Post群ではその割合は減少していた．また，skeletal Class IIIの症例ではアンカーを用いた非抜歯治療の割合が増加していた．High mandibular plane angle caseにおいてはアンカーの使用により，上顎第一大臼歯の挺出防止ならびに圧下が可能となり上下顎第一小臼歯を抜去する割合が増えた．【結論】アンカー導入で，臼歯の移動や挺出の防止および圧下が可能となり抜歯部位の選択基準に変化が生じたと考えられた．(著者抄録)
(キーワード): 下顎骨上顎骨小臼歯(外科的療法) *抜歯不正咬合-アングルI級(治療) 不正咬合-アングルII級(治療) 不正咬合-アングルIII級(治療) 治療成績 *歯科矯正用固定源埋込みヒト歯学

Eiji Tanaka, Shinji Fujihara and Chieko Shiota :
Case report update: A case of unilateral mandibular condylar osteochondroma treated with ipsilateral condylectomy and contralateral ramus osteotomy.,
AJO-DO Clinical Companion, Vol.1, No.1, 89-91, 2021.

(徳島大学機関リポジトリ): ● Metadata: 117303
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.xaor.2021.02.004
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.xaor.2021.02.004

(徳島大学機関リポジトリ: 117303, DOI: 10.1016/j.xaor.2021.02.004) Eiji Tanaka :
Biomechanical and tribological properties of the temporomandibular joint,
Frontiers of Oral and Maxillofacial Medicine, 2021.

(徳島大学機関リポジトリ): ● Metadata: 117302
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/fomm-20-83
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.21037/fomm-20-83

(徳島大学機関リポジトリ: 117302, DOI: 10.21037/fomm-20-83) Akiko Mino-Oka, Shinya Horiuchi, Rie Matsuda, Ryoko Shioyasono, Mohannad Ashtar, Masahiro Hiasa, Akihiro Yasue, Keiji Moriyama and Eiji Tanaka :
A Long-term Follow-up of Mandibular Deviation Caused by Congenital Cervical Lymphangioma Treated with an Orthodontic Approach.,
The Journal of Contemporary Dental Practice, Vol.22, No.6, 713-720, 2021.

(要約): The hybrid technique combining functional appliance and intermaxillary elastics proves to be an effective therapy for correcting occlusal cant and mandibular deviation caused by cervical lymphangioma.
(キーワード): Cephalometry / Facial Asymmetry / 女性 (female) / Follow-Up Studies / Humans / Lymphangioma / Malocclusion / Mandible
(徳島大学機関リポジトリ): ● Metadata: 116185
(出版サイトへのリンク): ● Publication site (DOI): 10.5005/jp-journals-10024-3115
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34393132; ● Summary page in Scopus @ Elsevier: 2-s2.0-85112843821

(徳島大学機関リポジトリ: 116185, DOI: 10.5005/jp-journals-10024-3115, PubMed: 34393132, Elsevier: Scopus) Tsendsuren Khurel-Ochir, Takashi Izawa, Akihiko Iwasa, Fumiya Kano, Akihito Yamamoto and Eiji Tanaka :
The immunoregulatory role of p21 in the development of the temporomandibular joint-osteoarthritis.,
Clinical and Experimental Dental Research, Vol.7, No.3, 313-322, 2021.

(要約): mice aged 8 weeks were divided into the untreated and treated groups. In the treated groups, mechanical stress was applied to the temporomandibular joint (TMJ) through forced mouth opening for 3 hr/day for 7 days. The dissected TMJs were assessed using micro-CT, histology, and immunohistochemistry.
(徳島大学機関リポジトリ): ● Metadata: 116060
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cre2.404
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33567474; ● Search Scopus @ Elsevier (PMID): 33567474; ● Search Scopus @ Elsevier (DOI): 10.1002/cre2.404

(徳島大学機関リポジトリ: 116060, DOI: 10.1002/cre2.404, PubMed: 33567474) Mitsuhiro Iwata, Atsushi Saito, Yuko Kuroda, Takehiro Shinohara, Daishi Arai, Hirofumi Horie and Eiji Tanaka :
Comprehensive treatment for severe periodontitis with pathologic tooth migration-related bimaxillary protrusion: A case report with 3-year follow-up.,
The Journal of the American Dental Association, Vol.152, No.6, 471-482.e2, 2021.

(要約): Favorable esthetics, stable occlusion, and highly cleansable periodontal tissues were achieved with well-planned interdisciplinary and comprehensive treatment, although the patient had severe periodontitis and PTM-related bimaxillary protrusion.
(徳島大学機関リポジトリ): ● Metadata: 117205
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.adaj.2021.02.017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34044978; ● Search Scopus @ Elsevier (PMID): 34044978; ● Search Scopus @ Elsevier (DOI): 10.1016/j.adaj.2021.02.017

(徳島大学機関リポジトリ: 117205, DOI: 10.1016/j.adaj.2021.02.017, PubMed: 34044978) Natalia García, Pelayo Fernández, Eiji Tanaka, Eva Barrientos, Jesús María Lamela-Rey, Alfonso Fernández-Canteli and Carlos Vicente Juan de :
Effect of region-dependent viscoelastic properties on the TMJ articular disc relaxation under prolonged clenching.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.119, 2021.

(要約): The disc of the temporomandibular joint (TMJ) is located between the mandibular condyle and temporal bone, and has an important load-bearing and stress absorbing function. The TMJ disc presents viscoelastic characteristics that are largely dependent on its collagen fibre and proteoglycan composition and organization. The purpose of this study is to investigate the possible effects of region-specific dynamic viscoelastic properties on stress relaxation during prolonged clenching. Two finite element models were used to compare the stress distribution within the TMJ disc, namely, one with uniform disc material property and another one with region-specific disc material properties. Similar results were observed in both models with slight differences in the location of maximum stress. Larger stresses were observed in all cases for the model with uniform disc material property. Moreover, the higher values for the model with uniform disc material property appeared in the lateral region, while in the model with region-specific disc properties, these values moved to the lateral and central region. This investigation confirms that both models are sufficiently accurate to investigate stress distribution in the TMJ disc, and, particularly, the model with the region-specific disc material properties ensure better simulations of the TMJ disc behaviour.
(キーワード): 有限要素解析 (finite element analysis) / Mandibular Condyle / Stress, Mechanical / Temporomandibular Joint / Temporomandibular Joint Disc / Weight-Bearing
(徳島大学機関リポジトリ): ● Metadata: 117544
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2021.104522
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33895662; ● Search Scopus @ Elsevier (PMID): 33895662; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2021.104522

(徳島大学機関リポジトリ: 117544, DOI: 10.1016/j.jmbbm.2021.104522, PubMed: 33895662) Taiji Nakano, Akira Nakajima, Hiroto Watanabe, Ayaka Osada, Yasuhiro Namura, Takayuki Yoneyama, Eiji Tanaka and Mitsuru Motoyoshi :
Evaluation of torque moment in esthetic brackets from bendable alloy wires.,
The Angle Orthodontist, Vol.91, No.5, 2021.

(要約): The current study identified the material characteristics of CR, ZR, and PC brackets during torque tooth movements. The present results demonstrate a characteristic combined effect between different esthetic brackets and bendable alloy wires.
(徳島大学機関リポジトリ): ● Metadata: 116184
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/081820-729.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33822872; ● Search Scopus @ Elsevier (PMID): 33822872; ● Search Scopus @ Elsevier (DOI): 10.2319/081820-729.1

(徳島大学機関リポジトリ: 116184, DOI: 10.2319/081820-729.1, PubMed: 33822872) Toyoaki Takagi, Sou Shimizu and Eiji Tanaka :
Surgical orthodontic treatment of skeletal mandibular protrusion with multiple impacted ankylosed teeth treated with alveolar corticotomy,
The Journal of Contemporary Dental Practice, Vol.22, No.4, 412-421, 2021.

(要約): To present a case of skeletal mandibular protrusion with multiple impacted ankylosed teeth, which were treated with conventional orthognathic surgery and alveolar corticotomy, respectively. Tooth ankylosis is characterized by the fusion of a root surface with the surrounding alveolar bone. Various treatment modalities for tooth ankylosis have been developed and are used commonly in the clinic. Corticotomy is defined as the application of intentional surgical injury to the cortical bone to mobilize a tooth with the adjacent bone and soft tissues. The corticotomy technique has been improved in recent years to avoid possible risks such as periodontal damage, tooth devitalization, and osseous necrosis due to an inadequate blood supply. A female patient aged 16 years and 3 months was diagnosed with anterior crossbite and the impaction and ankylosis of multiple canines. After the confirmation of ankylosis, alveolar corticotomy was performed on the maxillary left and mandibular right canines. After 6 months of traction (patient age, 19 years and 7 months), both canines had extruded successfully. After the completion of preoperative treatment, bilateral intraoral vertical ramus osteotomy was performed to correct the anterior crossbite involving a skeletal mandibular protrusion. The amounts of mandibular setback on the right and left sides were approximately 7 and 5 mm, respectively. The total treatment period was 55 months. Acceptable occlusion with a balanced profile was maintained over a 5-year retention period, indicating the long-term stability and success of the treatment. Our results indicate that alveolar corticotomy should be considered to facilitate the treatment of multiple impacted ankylosed teeth. This report proposes an efficacy of alveolar corticotomy for extrusion of impacted ankylosed teeth.
(キーワード): 成人 (adult) / Alveolar Process / Cuspid / 女性 (female) / Humans / Mandible / Tooth Ankylosis / Tooth Movement Techniques / Tooth, Impacted / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 117252
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34267012; ● Search Scopus @ Elsevier (PMID): 34267012

(徳島大学機関リポジトリ: 117252, PubMed: 34267012) 坂巻拓馬, 岩浅亮彦, 中村竜也, 田中栄二 :
矯正歯科治療中に生じた下顎中切歯の歯肉退縮に対して結合組織移植術を行った歯性上顎前突症例長期保定症例,
日本矯正歯科学会雑誌, Vol.80, No.1, 27-33, 2021年.

(要約): 歯肉退縮は，矯正治療中や治療後にしばしば生じるリスクのひとつであり，歯根面の露出により審美障害ならびに知覚過敏や根面う蝕などの問題を誘発する．歯肉退縮の予防を目的とした，矯正治療前の歯周外科処置も報告されているが，現時点では一般的ではなく，実際に歯肉退縮が発生した後，結合組織移植術(CTG)などの歯周形成外科手術によって対応しているのが現状である．今回我々は，歯性上顎前突患者の矯正治療中に下顎左側中切歯に生じた歯肉退縮に対して，1年10か月間の矯正治療終了後にCTGを施行し，術後6年経過した現在も歯肉退縮の再発を認めず，良好な状態が維持された症例を経験したため報告する．
(キーワード): 歯肉退縮 / 結合組織移植 / 上顎前突 / 長期保定
(徳島大学機関リポジトリ): ● Metadata: 116166
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854177641499264

(徳島大学機関リポジトリ: 116166, CiNii: 1570854177641499264) Natsuko Hichijo, Yasusei Kudo and Eiji Tanaka :
Orthodontic treatment of open bite involved in diffuse hypercementosis: A case report.,
The Journal of the American Dental Association, Vol.152, No.2, 166-175, 2021.

(要約): Open bite is considered one of the most complicated malocclusions in orthodontic treatment. In this study, the authors successfully treated total open bite involved in hypercementosis using orthodontic miniscrews. A woman aged 25 years 8 months had total open bite. Her occlusal contact at the maximum intercuspation was present at the right second molars. A panoramic radiograph showed diffuse hypercementosis. The titanium miniscrews were interradicullay implanted between the first and second molars, and intrusion force was applied for 14 months. After active treatment, the patient's maxillary first molars showed about 1.6-millimeters of intrusion, resulting in counterclockwise mandibular rotation. Her acceptable occlusion was maintained after 1.0-year retention. Miniscrews might be useful tool to improve malocclusion involved in diffuse hypercementosis though they are considered to be difficult to move and brought on ankylosis.
(キーワード): Adult / Cephalometry / Female / Humans / Hypercementosis / Malocclusion, Angle Class II / Open Bite / Orthodontic Anchorage Procedures / Tooth Movement Techniques
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.adaj.2020.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33203553; ● Search Scopus @ Elsevier (PMID): 33203553; ● Search Scopus @ Elsevier (DOI): 10.1016/j.adaj.2020.08.014

(DOI: 10.1016/j.adaj.2020.08.014, PubMed: 33203553) Hiroko Sato, Yuta Matsuki, N Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada :
Effects of water immersion on shear bond strength reduction after current application of resin-modified glass-ionomer-cements containing and not containing an ionic liquid.,
Dental Materials Journal, Vol.40, No.1, 35-43, 2021.

(要約): The enhancement in the bonding strength of advanced dental cements has enabled long-lasting dental restorations. However, the high bonding strength can cause difficulty in removing these restorations. Therefore, "smart" dental cements with simultaneous strong bonding and easy on-demand debonding ability are required. A resin-modified glass-ionomer-cement (RMGIC) with an ionic liquid (IL) has demonstrated significant reduction in the bonding strength with current application (CA). This research investigates the effect of immersion in distilled water on the electric conductivity and bonding strength of RMGIC with and without an IL and CA. The RMGIC without the IL exhibited significant electric conductivity after immersion, and a significant decrease in bonding strength with CA. In comparison, the electric conductivity after immersion and the decrease in bonding strength with CA were greater for RMGIC with the IL. Thus, the feasibility of smart dental cements capable of electrically debonding-on-demand is indicated.
(キーワード): Electric conductivity / Glass-ionomer-cement / Ionic-liquid / Shear bonding strength / Smart adhesive
(徳島大学機関リポジトリ): ● Metadata: 114725
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.2019-371
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32779608; ● Search Scopus @ Elsevier (PMID): 32779608; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2019-371

(徳島大学機関リポジトリ: 114725, DOI: 10.4012/dmj.2019-371, PubMed: 32779608) Susumu Abe, Miyagi Akane, Kaoru Yoshinaga, Yoshizo Matsuka, Fumihiro Matsumoto, Uyama Emi, Yoshitaka Suzuki, Masamitsu Ohshima, Kazuo Okura and Eiji Tanaka :
Immediate Effect of Masticatory Muscle Activity with Transcutaneous Electrical Nerve Stimulation in Muscle Pain of Temporomandibular Disorders Patients,
Journal of Clinical Medicine, Vol.9, No.10, 3330, 2020.

(要約): Transcutaneous electrical nerve stimulation (TENS) is a non-invasive treatment modality for acute and chronic pain. However, little information for muscle activity is available on the immediate effects of TENS in masticatory muscle pain related to temporomandibular disorders (TMDs). The present study aimed to evaluate the immediate effects of TENS treatment on TMD-related muscle pain. Thirty-six patients with TMD-related muscle pain and 39 healthy subjects served as TMD and control groups, respectively. For objective evaluations, maximum mouth opening, and maximum bite force were measured before and after TENS. The pain intensity was assessed according to a 100-mm visual analog scale (VAS). TENS was applied to painful muscles for 20 min with frequencies of 100-200 Hz. The treatment outcome was evaluated using Global Rating of Change (GRC) scales. In the TMD group, VAS values significantly decreased after TENS. Although there was significant increase in the maximum mouth opening after TENS for only TMD group, the maximum bite force of both groups was significantly greater after TENS. According to GRC scales, one patient with TMD-related muscle pain expressed negative feelings after TENS. Conclusively, TENS treatment might quickly relieve pain in masticatory muscles and improve masticatory functions in patients with TMD-related muscle pain.
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/jcm9103330
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33081336; ● Search Scopus @ Elsevier (PMID): 33081336; ● Search Scopus @ Elsevier (DOI): 10.3390/jcm9103330

(DOI: 10.3390/jcm9103330, PubMed: 33081336) Munenori Habuta, Akihiro Yasue, T Ken-Ichi Suzuki, Hirofumi Fujita, Keita Sato, Hitomi Kono, Ayuko Takayama, Tetsuya Bando, Satoru Miyaishi, Seiichi Oyadomari, Eiji Tanaka and Hideyo Ohuchi :
Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung.,
PLoS ONE, Vol.15, No.10, 2020.

(要約): CRISPR/Cas9-mediated gene editing often generates founder generation (F0) mice that exhibit somatic mosaicism in the targeted gene(s). It has been known that Fibroblast growth factor 10 (Fgf10)-null mice exhibit limbless and lungless phenotypes, while intermediate limb phenotypes (variable defective limbs) are observed in the Fgf10-CRISPR F0 mice. However, how the lung phenotype in the Fgf10-mosaic mutants is related to the limb phenotype and genotype has not been investigated. In this study, we examined variable lung phenotypes in the Fgf10-targeted F0 mice to determine if the lung phenotype was correlated with percentage of functional Fgf10 genotypes. Firstly, according to a previous report, Fgf10-CRISPR F0 embryos on embryonic day 16.5 (E16.5) were classified into three types: type I, no limb; type II, limb defect; and type III, normal limbs. Cartilage and bone staining showed that limb truncations were observed in the girdle, (type I), stylopodial, or zeugopodial region (type II). Deep sequencing of the Fgf10-mutant genomes revealed that the mean proportion of codons that encode putative functional FGF10 was 8.3 ± 6.2% in type I, 25.3 ± 2.7% in type II, and 54.3 ± 9.5% in type III (mean ± standard error of the mean) mutants at E16.5. Histological studies showed that almost all lung lobes were absent in type I embryos. The accessory lung lobe was often absent in type II embryos with other lobes dysplastic. All lung lobes formed in type III embryos. The number of terminal tubules was significantly lower in type I and II embryos, but unchanged in type III embryos. To identify alveolar type 2 epithelial (AECII) cells, known to be reduced in the Fgf10-heterozygous mutant, immunostaining using anti-surfactant protein C (SPC) antibody was performed: In the E18.5 lungs, the number of AECII was correlated to the percentage of functional Fgf10 genotypes. These data suggest the Fgf10 gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung. Since dysfunction of AECII cells has been implicated in the pathogenesis of parenchymal lung diseases, the Fgf10-CRISPR F0 mouse would present an ideal experimental system to explore it.
(徳島大学機関リポジトリ): ● Metadata: 115615
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0240333
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33057360; ● Search Scopus @ Elsevier (PMID): 33057360; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0240333

(徳島大学機関リポジトリ: 115615, DOI: 10.1371/journal.pone.0240333, PubMed: 33057360) Ayami Ito, Kazuna Tachiki, Ryoko Shioyasono, Mohannad Ashtar, Keiichiro Watanabe, Masahiro Hiasa and Eiji Tanaka :
Hemifacial Microsomia Caused by First and Second Brachial Arch Syndrome Treated with Orthodontic Approach: A Case Report.,
The Journal of Contemporary Dental Practice, Vol.21, No.10, 1189-1195, 2020.

(要約): This report proposes an efficacy of conventional orthodontic treatment for growing patients with hemifacial microsomia involved in the FSBAS.
(キーワード): Child / Dental Occlusion / Facial Asymmetry / 女性 (female) / Goldenhar Syndrome / Humans / 小児 (infant) / Mandible / Maxilla
(徳島大学機関リポジトリ): ● Metadata: 116453
(出版サイトへのリンク): ● Publication site (DOI): 10.5005/JP-JOURNALS-10024-2957
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33686045; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099979923

(徳島大学機関リポジトリ: 116453, DOI: 10.5005/JP-JOURNALS-10024-2957, PubMed: 33686045, Elsevier: Scopus) 片桐渉, 小林正治, 佐々木朗, 須佐美隆史, 須田直人, 田中栄二, 近津大地, 冨永和宏, 森山啓司, 山城隆, 齋藤功, 高橋哲 :
本邦における外科的矯正治療の実態調査-2017年度日本顎変形症学会実態調査の結果より-,
日本顎変形症学会雑誌, Vol.30, No.3, 213-225, 2020年.

(出版サイトへのリンク): ● Publication site (DOI): 10.5927/jjjd.30.213
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390567172571453056; ● Search Scopus @ Elsevier (DOI): 10.5927/jjjd.30.213

(DOI: 10.5927/jjjd.30.213, CiNii: 1390567172571453056) Eva Barrientos, Fernández Pelayo, Eiji Tanaka, Jesús María Lamela-Rey, Alfonso Fernández-Canteli and Carlos Vicente Juan de :
Effects of loading direction in prolonged clenching on stress distribution in the temporomandibular joint.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.112, 2020.

(要約): Parafunctional habits, such as bruxism and prolonged clenching, have been associated with dysfunctional hyperactivity of the masticatory muscles, including the lateral pterygoid muscle. The resultant loading to the temporomandibular joint (TMJ) is subject to the degradation of bone, cartilage and disc in the TMJ. In this study, we examined the effect of clenching direction on the stress distribution in the TMJ. In this line, we hypothesised that asymmetrical clenching involved in parafunction might result in increased stresses on the TMJ disc as well as on the condylar and temporal articular surfaces. The distribution of stress for various directional loadings was analysed using a three-dimensional finite element model of the TMJ, with viscoelastic properties for the disc. The numerical results revealed that load direction influenced the amount and distribution of stresses on the disc surfaces. In particular, the lateral region of the disc suffered higher stress values. Moreover, the results showed a significant stress relaxation in the disc that revealed its capacity for stress energy dissipation. From the present study, it can be established that during prolonged clenching, the higher stresses are concentrated in the lateral region, which could imply that TMJ disorders related to damage or wear in the disc and the condylar cartilage, overall, occur when lateral dysfunctional displacements are present.
(徳島大学機関リポジトリ): ● Metadata: 115888
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2020.104029
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32827997; ● Search Scopus @ Elsevier (PMID): 32827997; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2020.104029

(徳島大学機関リポジトリ: 115888, DOI: 10.1016/j.jmbbm.2020.104029, PubMed: 32827997) 清水宗, 堀内信也, 森浩喜, 天眞寛文, 岩浅亮彦, 渡邉佳一郎, 高木豊明, 田中栄二 :
徳島大学病院矯正歯科における保険診療に関する実態調査-先天性疾患における裂奇形の併発について,
中·四国矯正歯科学会雑誌, Vol.32, No.1, 87-92, 2020年.

(要約): 矯正歯科治療に健康保険が導入されて約40年が経過し，唇顎口蓋裂と顎変形症の他に2018年現在53項目が保険治療の対象になっている．今回，我々は当科における矯正歯科治療の保険適用患者の実態を調査し，特に唇顎口蓋裂と他の先天性疾患との関連性について臨床統計学的検討を行ったので報告する．徳島大学病院病院情報システム・データウェアハウスを用い，2008年1月から2018年12月までの11年間に当院矯正歯科を受診した患者から保険治療を受けている患者を抽出し，顎変形症単独症例を除く先天性疾患患者について，電子カルテ全文検索システムを用いて臨床統計学的検討を行った．研究対象期間に当科にて保険治療を受けた矯正患者は345人で，そのうち，本研究対象患者は，顎変形症単独症例を除く207人であった．患者の内訳は，裂奇形を主徴候とする症例が全体の5割を占め最も多く，次いで，6歯以上の先天性部分性無歯症，ゴールデンハー症候群(鰓弓異常症を含む)，ダウン症候群の順であった．また，症候性疾患の中で裂奇形の併発は，ピエール・ロバン症候群，ダウン症候群，ゴールデンハー症候群の順に多く，その裂型は，口蓋裂(軟口蓋裂を含む)，唇顎口蓋裂，唇裂の順に多かった．以上のことから，当病院は裂奇形を併発した先天性疾患への専門的な対応が不可欠であり，希少疾患にも柔軟に対応できるよう複数の診療科，職種による診療科の枠組みを超えたチーム医療体制の構築が必要であることが示唆された．
(キーワード): 先天性疾患 / 口唇裂・口蓋裂 / 臨床統計学的調査 / 合併症
(徳島大学機関リポジトリ): ● Metadata: 116914

(徳島大学機関リポジトリ: 116914) Aki Ichihara, Akihiro Yasue, Silvia Naomi Mitsui Akagi, Daishi Arai, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto and Eiji Tanaka :
The C-terminal region including the MH6 domain of Msx1 regulates skeletal development.,
Biochemical and Biophysical Research Communications, Vol.526, No.1, 62-69, 2020.

(要約): MSX1 is a causative gene for oligodontia in humans. Although conventional Msx1-deficient mice die neonatally, a mutant mouse lacking the C-terminus MH6 domain of MSX1 (Msx1) showed two different phenotypes; newborn homozygotes with cleft palates died neonatally, whereas those with thin palates remained alive and had craniofacial dysplasia and growth retardation compared with wild-type mice, with most mice dying by the age of 4-5 weeks. In a previously reported case of human oligodontia caused by a heterozygous defect of the Msx1 MH6 domain, a small foramen was observed on the occipital bone. The aim of this study was to test the hypothesis that the Msx1 MH6 domain is involved in bone formation in vivo. In Msx1 mice, cranial suture fusion was delayed at embryonic day 18.5, and the anteroposterior cranial diameter was smaller and long bone length was decreased at 3 weeks of age. The femoral epiphysis showed no change in the trabecular number, but decreased bone mass, bone density, and trabecular width in Msx1 mice. In addition, cancellous bone mass was reduced and the cartilage layer in the growth plate was thinner in Msx1 mice. The mRNA expression levels of major osteoblast and chondrocyte differentiation marker genes were decreased in Msx1 mice compared with wild-type mice. These findings suggest that the C-terminal region including the MH6 domain of MSX1 plays important roles not only in tooth development and palatal fusion, but also in postnatal bone formation.
(徳島大学機関リポジトリ): ● Metadata: 115012
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2020.03.068
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32192766; ● Summary page in Scopus @ Elsevier: 2-s2.0-85081698937

(徳島大学機関リポジトリ: 115012, DOI: 10.1016/j.bbrc.2020.03.068, PubMed: 32192766, Elsevier: Scopus) Mohannad Ashtar, Hirofumi Tenshin, Jumpei Teramachi, Ariunzaya Bat-Erdene, Masahiro Hiasa, Asuka Oda, Kotaro Tanimoto, Sou Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Shingen Nakamura, Shiroh Fujii, Ryohei Sumitani, Hirokazu Miki, Kengo Udaka, Mamiko Takahashi, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat.,
Cancers, Vol.12, No.4, 2020.

(要約): Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of uric acid but also the formation of reactive oxygen species (ROS). ROS has been demonstrated to mediate RANKL-mediated osteoclastogenesis. In the present study, we therefore explored the role of cancer-treatment-induced ROS in RANKL-mediated osteoclastogenesis and the suppressive effects of febuxostat on ROS generation and osteoclastogenesis. RANKL dose-dependently induced ROS production in RAW264.7 preosteoclastic cells; however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. Interestingly, doxorubicin (Dox) further enhanced RANKL-induced osteoclastogenesis through upregulation of ROS production, which was mostly abolished by addition of febuxostat. Febuxostat also inhibited osteoclastogenesis enhanced in cocultures of bone marrow cells with MM cells. Importantly, febuxostat rather suppressed MM cell viability and did not compromise Dox's anti-MM activity. In addition, febuxostat was able to alleviate pathological osteoclastic activity and bone loss in ovariectomized mice. Collectively, these results suggest that excessive ROS production by aberrant RANKL overexpression and/or anticancer treatment disadvantageously impacts bone, and that febuxostat can prevent the ROS-mediated osteoclastic bone damage.
(徳島大学機関リポジトリ): ● Metadata: 115041
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/cancers12040929
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32283857; ● Search Scopus @ Elsevier (PMID): 32283857; ● Search Scopus @ Elsevier (DOI): 10.3390/cancers12040929

(徳島大学機関リポジトリ: 115041, DOI: 10.3390/cancers12040929, PubMed: 32283857) Nobuhiko Kawai, Manami Shibata, Masahiko Watanabe, Shinya Horiuchi, Kenji Fushima and Eiji Tanaka :
Effects of functional training after orthognathic surgery on masticatory function in patients with mandibular prognathism.,
Journal of Dental Sciences, Vol.15, No.4, 419-425, 2020.

(要約): In the training group, the AI value during MVC increased significantly and the EI value during gam chewing decreased significantly after surgical orthodontic treatment (AI: p < 0.01; EI: p < 0.01), indicating the improvement of activity balance of masseter and temporalis muscles and conversion of the jaw movement from abnormal to normal pattern (p < 0.01).
(徳島大学機関リポジトリ): ● Metadata: 115567
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jds.2020.01.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33505611; ● Search Scopus @ Elsevier (PMID): 33505611; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jds.2020.01.006

(徳島大学機関リポジトリ: 115567, DOI: 10.1016/j.jds.2020.01.006, PubMed: 33505611) Naoko Ogasawara, Fumiya Kano, Noboru Hashimoto, Hiroki Mori, YAO LIU, LINZE XIA, Takuma Sakamaki, Hideharu Hibi, Tsutomu Iwamoto, Eiji Tanaka and Akihito Yamamoto :
Factors Secreted from Dental Pulp Stem Cells Show Multifaceted Benefits for Treating Experimental Temporomandibular Joint Osteoarthritis,
Osteoarthritis and Cartilage, Vol.28, No.6, 831-841, 2020.

(要約): Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by progressive cartilage degeneration, abnormal bone remodeling, and chronic pain. In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression. To this end, we performed intravenous administration of serum free conditioned media from human exfoliated deciduous teeth stem cells (SHED-CM) into a mechanical-stress induced murine TMJOA model. SHED-CM administration markedly suppressed temporal muscle inflammation, and improved bone integrity and surface smoothness of the destroyed condylar cartilage. Moreover, SHED-CM treatment decreased the number of IL-1β, iNOS, and MMP-13 expressing chondrocytes, whereas it specifically increased PCNA-positive cells in the multipotent polymorphic cell layer. Notably, the numbers of TUNEL-positive apoptotic chondrocytes in the SHED-CM treated condyles were significantly lower than in those treated with DMEM, whereas the proteoglycan positive area was restored to a level similar to that of the sham treated group, demonstrating that SHED-CM treatment regenerated the mechanical-stress injured condylar cartilage and subchondral bone. Secretome analysis revealed that SHED-CM contained multiple therapeutic factors that act in osteochondral regeneration. Our data demonstrated that SHED-CM treatment promoted the regeneration and repair of mechanical-stress induced mouse TMJOA. Our observations suggest that SHED-CM has potential to be a potent tissue-regenerating therapeutic agent for patients with severe TMJOA.
(徳島大学機関リポジトリ): ● Metadata: 115291
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.joca.2020.03.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32272195; ● Search Scopus @ Elsevier (PMID): 32272195; ● Search Scopus @ Elsevier (DOI): 10.1016/j.joca.2020.03.010

(徳島大学機関リポジトリ: 115291, DOI: 10.1016/j.joca.2020.03.010, PubMed: 32272195) Chihiro Arai, Nobuhiko Kawai, Yoshiaki Nomura, Atsushi Tsuge, Yoshiki Nakamura and Eiji Tanaka :
Low-intensity pulsed ultrasound enhances the rate of lateral tooth movement and compensatory bone formation in rats.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.157, No.1, 59-66, 2020.

(要約): The present study provides evidence of the beneficial effects of LIPUS on the lateral tooth movement.
(徳島大学機関リポジトリ): ● Metadata: 114290
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2019.01.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31901282; ● Search Scopus @ Elsevier (PMID): 31901282; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2019.01.027

(徳島大学機関リポジトリ: 114290, DOI: 10.1016/j.ajodo.2019.01.027, PubMed: 31901282) Mitsuhiro Iwata, Atsushi Saito, Yuko Kuroda, Takehiro Shinohara and Eiji Tanaka :
Interdisciplinary therapy for severe periodontitis with Angle Class II Division 1 malocclusion: A case report with 7-year follow-up,
The Journal of the American Dental Association, Vol.150, No.11, 960-971, 2019.

(要約): Previous studies have suggested that occlusal discrepancy is a risk factor contributing to periodontal disease. Occlusal discrepancy could increase the risk of developing infrabony defects. The authors present a case of a patient with severe periodontitis who exhibited many infrabony defects in the molar region due to malocclusion-induced trauma. They report the 7-year treatment outcomes of the patient after periodontal regenerative and comprehensive orthodontic therapies for functional recovery with implant prosthodontics. A 56-year-old woman sought treatment with the chief symptom of masticatory disturbance. In the molar region, excessive tooth mobility, deep periodontal pockets, and infrabony defects were observed. She had excessive overjet, resulting in collapse of anterior guidance. Malocclusion was considered to be an exacerbating factor of the infrabony defects. After initial periodontal therapy, the authors performed periodontal regenerative therapy in the mandibular molar regions. The authors carefully placed implants in a position in the maxillary molar region that would ensure an appropriate anterior dental relationship after orthodontic treatment. Comprehensive orthodontic treatment was subsequently performed, using implants as anchoring units. Definitive surgery was then performed on the mandibular molars before placing the final prosthesis. Favorable periodontal condition and stable occlusion have been maintained for the 7-year posttreatment period. Comprehensive and interdisciplinary treatment enables stable occlusion and establishment of periodontal and peri-implant tissues with high cleansability, even in patients with severe periodontitis and malocclusion. In this case, a favorable long-term treatment outcome can be expected.
(徳島大学機関リポジトリ): ● Metadata: 114289
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.adaj.2019.06.012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31668173; ● Summary page in Scopus @ Elsevier: 2-s2.0-85073627971

(徳島大学機関リポジトリ: 114289, DOI: 10.1016/j.adaj.2019.06.012, PubMed: 31668173, Elsevier: Scopus) 吉村宗之, 泰江章博, 七條なつ子, 田中栄二 :
正中二分割Le Fort I型骨切り術併用による上下顎同時移動術を施行した骨格性下顎前突症の一例,
中·四国矯正歯科学会雑誌, Vol.31, No.1, 31-38, 2019年.

(徳島大学機関リポジトリ): ● Metadata: 116913

(徳島大学機関リポジトリ: 116913) Eva Barrientos, Fernandez Pelayo, Eiji Tanaka, Jesús María Lamela-Rey and Alfonso Fernández-Canteli :
Viscoelastic properties of the central region of porcine temporomandibular joint disc in shear stress-relaxation.,
Journal of Biomechanics, Vol.93, 126-131, 2019.

(要約): In this study, shear relaxation properties of the porcine temporomandibular joint (TMJ) disc are investigated. Previous studies have shown that, in fatigue failure and damage of cartilage and fibrocartilage, shear loads could be one of the biggest contributors to the failure. The aim of the present study is to develop an evaluation method to study shear properties of the disc and to do a mathematical characterization of it. For the experiments, twelve porcine discs were used. Each disc was dissected from the TMJ and, then, static strain control tests were carried out to obtain the shear relaxation modulus for the central region of the discs. From the results, it was found that the disc presents a viscoelastic behavior under shear loads. Relaxation modulus decreased with time. Shear relaxation was 10% of the instantaneous stress, which implies that the viscous properties of the disc cannot be neglected. The present results lead to a better understanding of the discs mechanical behavior under realistic TMJ working conditions.
(徳島大学機関リポジトリ): ● Metadata: 114281
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jbiomech.2019.06.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31301763; ● Search Scopus @ Elsevier (PMID): 31301763; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jbiomech.2019.06.023

(徳島大学機関リポジトリ: 114281, DOI: 10.1016/j.jbiomech.2019.06.023, PubMed: 31301763) Eva Barrientos, Fernandez Pelayo, A Noriega, Jesús María Lamela-Rey, Alfonso Fernández-Canteli and Eiji Tanaka :
Optimal discrete-time Prony series fitting method for viscoelastic materials.,
Mechanics of Time-Dependent Materials, Vol.23, No.2, 193-206, 2019.

(徳島大学機関リポジトリ): ● Metadata: 116607
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11043-018-9394-z
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85049607374

(徳島大学機関リポジトリ: 116607, DOI: 10.1007/s11043-018-9394-z, Elsevier: Scopus) 谷本幸多朗, 森浩喜, 木内奈央, 井澤俊, 泰江章博, 堀内信也, 峯田一秀, 石田創士, 岩本勉, 橋本一郎, 田中栄二 :
徳島大学病院矯正歯科における過去10年間の口唇裂・口蓋裂患者に関する実態調査．,
日本口蓋裂学会雑誌, Vol.44, No.1, 1-6, 2019年.

(要約): 徳島大学病院矯正歯科に来院した口唇裂・口蓋裂患者の実態を把握する目的で，2006年4月から2016年3月までの10年間に当科を受診した口唇裂・口蓋裂患者を対象として臨床統計を行い，以下の結果を得た． 1．過去10年間の口唇裂・口蓋裂患者は96名であり，矯正歯科総患者数の6.16%を占めていた．男女比は1:0.75であった． 2．裂型分類では唇顎口蓋裂(36.5%)，口唇顎裂(33.3%)，口蓋裂(19.8%)，口唇裂(10.4%)であった．披裂部の側性は唇顎口蓋裂，口唇顎裂においては左側に，口唇裂では右側に高い割合でみられた．裂型別性差に関しては口唇裂，口唇顎裂，唇顎口蓋裂においては男子に，口蓋裂においては女子に高い割合で認められた． 3．初診時年齢は0歳(58.3%)が最も多く，次いで1歳(11.5%)，2歳(7.3%)と続いた．初診時におけるHellmanの咬合発育段階で分類すると，乳歯咬合完成前のⅠA期(44.8%)が最も多く，次にⅠC期(32.3)，ⅡA期(7.3%)と続いた． 4．患者の居住地の地域分布は徳島県が87.5%で最も多く認められた． 5．紹介元の医療施設においては，当院形成外科からの紹介が90.6%を占めていた． 6．交叉咬合の分類において，前歯のみが交叉咬合を呈するType 4が52.9%と最も高かった．
(キーワード): 口唇裂・口蓋裂 / 実態調査 / 矯正歯科
(出版サイトへのリンク): ● Publication site (DOI): 10.11224/cleftpalate.44.1
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238103018368; ● Search Scopus @ Elsevier (DOI): 10.11224/cleftpalate.44.1

(DOI: 10.11224/cleftpalate.44.1, CiNii: 1390564238103018368) Islamy Rahma Hutami, Eiji Tanaka and Takashi Izawa :
Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis,
Japanese Dental Science Review, Vol.55, No.1, 12-19, 2019.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL) / 自己免疫 (autoimmunity) / アポトーシス (apoptosis)
(徳島大学機関リポジトリ): ● Metadata: 113501
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jdsr.2018.09.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30733840; ● Search Scopus @ Elsevier (PMID): 30733840; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdsr.2018.09.004

(徳島大学機関リポジトリ: 113501, DOI: 10.1016/j.jdsr.2018.09.004, PubMed: 30733840) Natsuko Hichijo, Masahiro Furutani, Shingo Kuroda and Eiji Tanaka :
Excessive gingival display treated with 2-piece segmental Le Fort I osteotomy: A case report.,
The Journal of the American Dental Association, Vol.150, No.1, 58-68, 2018.

(要約): It is hoped that 2-piece segmental Le Fort I osteotomy becomes a common treatment option for patients with protrusive profiles and excessive gingival displays.
(徳島大学機関リポジトリ): ● Metadata: 113502
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.adaj.2018.09.020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30470390; ● Search Scopus @ Elsevier (PMID): 30470390; ● Search Scopus @ Elsevier (DOI): 10.1016/j.adaj.2018.09.020

(徳島大学機関リポジトリ: 113502, DOI: 10.1016/j.adaj.2018.09.020, PubMed: 30470390) 小笠原直子, 岩浅亮彦, 堀内信也, 市原亜起, 泰江章博, 川合暢彦, 井澤俊, 田中栄二 :
矯正患者における永久歯の先天性欠如に関する臨床統計調査,
中·四国矯正歯科学会雑誌, Vol.30, No.1, 59-64, 2018年.

(徳島大学機関リポジトリ): ● Metadata: 116912

(徳島大学機関リポジトリ: 116912) 市原亜起, 堀内信也, 小笠原直子, 森浩喜, 天知良太, 渡邉佳一郎, 木内奈央, 泰江章博, 田中栄二 :
徳島大学病院矯正歯科における口唇裂・口蓋裂患者の永久歯の歯数異常に関する調査,
中·四国矯正歯科学会雑誌, Vol.30, No.1, 51-58, 2018年.

(徳島大学機関リポジトリ): ● Metadata: 116911

(徳島大学機関リポジトリ: 116911) Naoki Maeda, Hidehiko Hosoki, Midori Yoshida, Hideki Suito, Oyunbat Dashpuntsag, Fumihiro Matsumoto, Yoshizo Matsuka, Eiji Tanaka and Eiichi Honda :
Time-course observation of patients with arthrosis of the temporomandibular joint on MRI,
Journal of Oral Health and Biosciences, Vol.31, No.1, 25-31, 2018.

(要約): Patients with arthrosis of the temporomandibular joint are examined by MRI, but fewer cases are followed over time by performing MRI several times. The objective of this study was to investigate the presence or absence and types of changes in the structure of the mandibular condyle and articular disc on MR images over time in patients examined by MRI for the diagnosis of arthritis of the temporomandibular joint in order to clarify the usefulness of performing MRI several times. MR images for patients who underwent MRI several times based on the clinical diagnosis of arthrosis of the temporomandibular joint were analyzed. Twenty-three patients were examined by MRI twice or more. The shortest and longest intervals between the first and final examinations were 75 and 2,588 days, respectively, and the mean was 735 days. Changes in the bone structure of the mandibular condyle were noted on the first MRI in approximately 63 % and new changes were noted on the final examination in approximately 24 %. In addition, the articular disc position in the closed or open mouth had changed on the later examinationin approximately 15 %. Performing MRI several times along the clinical course was found to be useful to diagnose the disease stage, judge the treatment effects, and help predict the outcome in patients with arthrosis of the temporomandibular joint.
(キーワード): TMJ / follow-up / morphology / displacement
(徳島大学機関リポジトリ): ● Metadata: 111933
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.31.1_25
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390845712973015552; ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_25

(徳島大学機関リポジトリ: 111933, DOI: 10.20738/johb.31.1_25, CiNii: 1390845712973015552) Megumi Takada, Akira Nakajima, Shingo Kuroda, Shinya Horiuchi, Noriyoshi Shimizu and Eiji Tanaka :
In vitro evaluation of frictional force of a novel elastic bendable orthodontic wire.,
The Angle Orthodontist, Vol.88, No.5, 602-610, 2018.

(要約): These findings demonstrate that the Ti-Nb alloy wire has almost the same frictional resistance as the Ti-Ni alloy wire, although it has a higher elastic modulus.
(徳島大学機関リポジトリ): ● Metadata: 113503
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/111417-779.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29799272; ● Search Scopus @ Elsevier (PMID): 29799272; ● Search Scopus @ Elsevier (DOI): 10.2319/111417-779.1

(徳島大学機関リポジトリ: 113503, DOI: 10.2319/111417-779.1, PubMed: 29799272) Takashi Izawa, Islamy Rahma Hutami and Eiji Tanaka :
Potential role of rebamipide in osteoclast differentiation and mandibular condylar cartilage homeostasis,
Current Rheumatology Reviews, Vol.14, No.1, 62-69, 2018.

(要約): Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that involves changes in subchondral bone and progressive degradation of cartilage. Currently, rebamipide, a gastroprotective drug, is administered to protect gastric mucosa and accelerate ulcer healing. Recent studies have shown that rebamipide also attenuates cartilage degeneration by suppressing oxidative damage and inducing homeostasis of the extracellular matrix of articular chondrocytes. Regarding the latter, reduced expression of cathepsin K, NFATc1, c-Src, and integrin 3, and increased expression of nuclear factor-kappa B, have been found to be mediated by the transcription factor, receptor activator of nuclear factor kappa-B ligand (RANKL). Treatment with rebamipide was also found to activate, mitogen-activated protein kinases such as p38, ERK, and JNK to reduce osteoclast differentiation. Taken together, these results strongly indicate that rebamipide mediates inhibitory effects on cartilage degradation and osteoclastogenesis in TMJ-OA. Here, we highlight recent evidence regarding the potential for rebamipide to affect osteoclast differentiation and TMJ-OA pathogenesis. We also discuss the potential for rebamipide to serve as a new strategy for the treatment of TMJ-OA.
(徳島大学機関リポジトリ): ● Metadata: 113510
(出版サイトへのリンク): ● Publication site (DOI): 10.2174/1573397113666171017113441
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29046162; ● Search Scopus @ Elsevier (PMID): 29046162; ● Search Scopus @ Elsevier (DOI): 10.2174/1573397113666171017113441

(徳島大学機関リポジトリ: 113510, DOI: 10.2174/1573397113666171017113441, PubMed: 29046162) Shinya Horiuchi, Hiromichi Yumoto, Tomoko Kimura, Minami Sato, Silvia Naomi Mitsui Akagi, Masahiro Hiasa, Eiji Nishikawa, Tarek El-Bialy and Eiji Tanaka :
Effect of pulsed ultrasound toothbrush on Streptococcus mutans biofilm removal.,
American Journal of Dentistry, Vol.31, No.2, 67-70, 2018.

(要約): The sonic vibration with pulsed ultrasound showed more reduction of the biofilm compared to the control and the sonic vibration with and without continuous ultrasound. Thus, pulsed ultrasound action may be beneficial for biofilm removal of interproximal regions.
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29630788; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047330699

(PubMed: 29630788, Elsevier: Scopus) Takayuki Uchida, Yoshihiro Sakashita, Kanako Kitahata, Yui Yamashita, Chisato Tomida, Yuki Kimori, Akio Komatsu, Katsuya Hirasaka, Ayako Maita, Reiko Nakao, Atsushi Higashitani, Akira Higashibata, Noriaki Ishioka, Toru Shimazu, Takeshi Kobayashi, Yuushi Okumura, Inho Choi, Motoko Oarada, M Edward Mills, Shigetada Kondo, Shin'ichi Takeda, Eiji Tanaka, Keiji Tanaka, Masahiro Sokabe and Takeshi Nikawa :
Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.,
American Journal of Physiology, Cell Physiology, Vol.314, No.6, C721-C731, 2018.

(要約): Unloading-mediated muscle atrophy is associated with increased reactive oxygen species (ROS) production. We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume [Nakao R. et al. Mol Cell Biol, 29: 4798-4811, 2009]. However, the pathological role of ROS production associated with unloading-mediated muscle atrophy still remains unknown. Here, we showed the ROS-mediated signal transduction caused by microgravity or its simulation contributes to Cbl-b expression. In L6 myotubes, the assessment of redox status revealed that oxidized glutathione was increased under microgravity conditions, and simulated microgravity caused a burst of ROS, implicating ROS as a critical upstream mediator linking to downstream atrophic signaling. ROS generation activated the ERK1/2-early growth response protein (Egr) 1/2-Cbl-b signaling pathway, an established contributing pathway to muscle volume loss. Interestingly, antioxidant treatment, such as N-acetylcysteine and TEMPOL, but not catalase, blocked the clinorotation-mediated activation of ERK1/2. The increased ROS induced transcriptional activity of Egr 1 and/or Egr 2 to stimulate Cbl-b expression through the ERK 1/2 pathway in L6 myoblasts, since treatment with Egr 1/2 siRNA and an ERK 1/2 inhibitor significantly suppressed clinorotation-induced Cbl-b and Egr expression, respectively. Promoter and gel mobility shift assays revealed that Cbl-b was upregulated via an Egr consensus oxidative responsive element at -110 to -60 bp of the Cbl-b promoter. Together this indicates that under microgravity conditions, elevated ROS may be a crucial mechanotransducer in skeletal muscle cells, regulating muscle mass, through Cbl-b expression activated by the ERK-Egr signaling pathway.
(徳島大学機関リポジトリ): ● Metadata: 111610
(出版サイトへのリンク): ● Publication site (DOI): 10.1152/ajpcell.00184.2017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29513566; ● Search Scopus @ Elsevier (PMID): 29513566; ● Search Scopus @ Elsevier (DOI): 10.1152/ajpcell.00184.2017

(徳島大学機関リポジトリ: 111610, DOI: 10.1152/ajpcell.00184.2017, PubMed: 29513566) Manami Shirai, Nobuhiko Kawai, Natsuko Hichijo, Masahiko Watanabe, Hiroyo Mori, Silvia Naomi Mitsui Akagi, Akihiro Yasue and Eiji Tanaka :
Effects of gum chewing exercise on maximum bite force according to facial morphology.,
Clinical and Experimental Dental Research, Vol.4, No.2, 48-51, 2018.

(要約): Development of the masticatory system is influenced by functional needs. Furthermore, masticatory exercise can improve masticatory function. The aim of this study was to evaluate the potential effect of the gum chewing exercise on the maximum bite force (MBF) in adult subjects with different facial morphologies. MBF was measured by a portable occlusal force gauge and lateral cephalogram was used for evaluation of craniofacial morphology in 19 individuals (7 males and 12 females) with a mean age of 25.4 years (SD ± 4.3). The volunteers underwent gum chewing exercise for 5 min twice a day for 4 weeks. MBF was measured before (T1) and after the 4-week exercise (T2). The facial morphology of the subjects was classified into the brachy (n = 7), mesio (n = 7), and dolicho (n = 5) facial types. In all three groups, exercise was associated with a significant increase in MBF, though the percent increase was highest in the dolicho facial type. We conclude that gum chewing exercise can improve masticatory performance, especially in individuals with dolicho facial morphology.
(徳島大学機関リポジトリ): ● Metadata: 111806
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cre2.102
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29744215; ● Summary page in Scopus @ Elsevier: 2-s2.0-85042275080

(徳島大学機関リポジトリ: 111806, DOI: 10.1002/cre2.102, PubMed: 29744215, Elsevier: Scopus) Nao Kinouchi, Shinya Horiuchi, Akihiro Yasue, Yuko Kuroda, Nobuhiko Kawai, Keiichiro Watanabe, Takashi Izawa, Ichiro Hashimoto, H Ali Hassan and Eiji Tanaka :
Effectiveness of presurgical nasoalveolar molding therapy on unilateral cleft lip nasal deformity.,
Saudi Medical Journal, Vol.39, No.2, 169-178, 2018.

(要約): To evaluate the effectiveness of pre-surgical nasoalveolar molding (PNAM) in patients with unilateral cleft lip nasal deformities. Methods: This was a retrospective study involving 29 patients with unilateral cleft lip and palate defects, of whom 13 were treated with palatal devices with nasal stents (PNAM group) and 16 were treated with palatal devices without nasal stents or surgical tapes (control group). Submental oblique photographs and orthodontic models were longitudinally obtained at the initial visit (T1) and immediately before (T2) and after cheiloplasty (T3). Asymmetry of the external nose, degree of columellar shifting, nasal tip/ala nose ratio, nasal base angle, interalveolar gap, and the sagittal difference in the alveolar gap were measured. The study was conducted in the Orthodontic Clinic at Tokushima University Hospital, Tokushima, Japan between 1997 and 2012. Results: At T1, there were no significant intergroup differences in the first 4 asymmetry parameters. At T2, the PNAM group showed a significant improvement in all values compared to the control group. At T3, the PNAM group showed significant improvement in nasal asymmetry and columellar shifting. Model analysis showed significantly greater changes in the inter-alveolar gap and the sagittal difference of the alveolar cleft gap from T1 to T2 in the PNAM group. Conclusion: The use of PNAM is indispensable for pre-surgical orthodontic treatment at the early postnatal age.
(徳島大学機関リポジトリ): ● Metadata: 113505
(出版サイトへのリンク): ● Publication site (DOI): 10.15537/smj.2018.2.21020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29436566; ● Search Scopus @ Elsevier (PMID): 29436566; ● Search Scopus @ Elsevier (DOI): 10.15537/smj.2018.2.21020

(徳島大学機関リポジトリ: 113505, DOI: 10.15537/smj.2018.2.21020, PubMed: 29436566) Shingo Kuroda, Masahide Inoue, Hee-Moon Kyung, Harm Jan Koolstra and Eiji Tanaka :
Stress Distribution in Obliquely Inserted Orthodontic Miniscrews Evaluated by Three-Dimensional Finite-Element Analysis.,
The International Journal of Oral & Maxillofacial Implants, Vol.32, No.2, 344-349, 2017.

(要約): An obliquely inserted miniscrew and its surrounding tissues generally provide sufficient anchorage for 2 N of orthodontic loading, but care must be taken to avoid screw failure during placement and removal of obliquely placed miniscrews.
(出版サイトへのリンク): ● Publication site (DOI): 10.11607/jomi.5061
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27525519; ● Summary page in Scopus @ Elsevier: 2-s2.0-85015756409

(DOI: 10.11607/jomi.5061, PubMed: 27525519, Elsevier: Scopus) Akihiko Iwasa, Shinya Horiuchi, Nao Kinouchi, Takashi Izawa, Masahiro Hiasa, Nobuhiko Kawai, Akihiro Yasue, H Ali Hassan and Eiji Tanaka :
Skeletal anchorage for intrusion of bimaxillary molars in a patient with skeletal open bite and temporomandibular disorders.,
Journal of Orthodontic Science, Vol.6, No.4, 152-158, 2017.

(要約): The treatment of severe skeletal anterior open bite is extremely difficult in adults, and orthognathic surgery is generally selected for its treatment. We report the case of an 18-year-old adult patient with skeletal anterior open bite and temporomandibular disorders who was successfully treated using temporary anchorage devices. She had an open bite of -2.0 mm and an increased facial height. Miniplates were implanted in both the maxilla and mandible, and molar intrusion resulted in counterclockwise rotation of the mandible over a period of 12 months. After active treatment, her upper and lower first molars were intruded by approximately 2 mm and her overbite became +2.5 mm. Her retrognathic profile improved with counterclockwise rotation of the mandible. Orthodontic treatment aided with skeletal anchorage is beneficial for intrusion of bimaxillary molars in patients with anterior open bite.
(徳島大学機関リポジトリ): ● Metadata: 113509
(出版サイトへのリンク): ● Publication site (DOI): 10.4103/jos.JOS_63_17
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29119097; ● Search Scopus @ Elsevier (PMID): 29119097; ● Search Scopus @ Elsevier (DOI): 10.4103/jos.JOS_63_17

(徳島大学機関リポジトリ: 113509, DOI: 10.4103/jos.JOS_63_17, PubMed: 29119097) Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiroh Fujii, Kumiko Kagawa, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Kiyoe Kurahashi, Sumiko Yoshida, Kenichi Aihara, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects.,
Blood Advances, Vol.1, No.24, 2124-2137, 2017.

(要約): Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) agonists induce tumor-specific apoptosis indicating that they may be an attractive therapeutic strategy against cancers, including multiple myeloma (MM). Osteoclastogenesis is highly induced in MM, which in turn enhances MM growth, thereby forming a vicious cycle between MM tumor expansion and bone destruction. However, the effects of TRAIL on MM-enhanced osteoclastogenesis remain largely unknown. Here, we show that TRAIL induced apoptosis in MM cells, but not in osteoclasts (OCs), and that it rather facilitated receptor activator of NF-B ligand-induced osteoclastogenesis along with upregulation of cellular FLICE inhibitory protein (c-FLIP). TRAIL did not induce death-inducing signaling complex formation in OCs, but formed secondary complex (complex II) with the phosphorylation of transforming growth factor -activated kinase-1 (TAK1), and thus activated NF-B signaling. c-FLIP knockdown abolished complex II formation, thus permitting TRAIL induction of OC cell death. The TAK1 inhibitor LLZ1640-2 abrogated the TRAIL-induced c-FLIP upregulation and NF-B activation, and triggered TRAIL-induced caspase-8 activation and cell death in OCs. Interestingly, the TRAIL-induced caspase-8 activation caused enzymatic degradation of the transcription factor Sp1 to noticeably reduce c-FLIP expression, which further sensitized OCs to TRAIL-induced apoptosis. Furthermore, the TAK1 inhibition induced antiosteoclastogenic activity by TRAIL even in cocultures with MM cells while potentiating TRAIL's anti-MM effects. These results demonstrated that osteoclastic lineage cells use TRAIL for their differentiation and activation through tilting caspase-8-dependent apoptosis toward NF-B activation, and that TAK1 inhibition subverts TRAIL-mediated NF-B activation to resume TRAIL-induced apoptosis in OCs while further enhancing MM cell death in combination with TRAIL.
(徳島大学機関リポジトリ): ● Metadata: 111724
(出版サイトへのリンク): ● Publication site (DOI): 10.1182/bloodadvances.2017008813
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29296860; ● Search Scopus @ Elsevier (PMID): 29296860; ● Search Scopus @ Elsevier (DOI): 10.1182/bloodadvances.2017008813

(徳島大学機関リポジトリ: 111724, DOI: 10.1182/bloodadvances.2017008813, PubMed: 29296860) Islamy Rahma Hutami, Takashi Izawa, Akiko Mino, Takehiro Shinohara, Hiroki Mori, Akihiko Iwasa and Eiji Tanaka :
Fas/S1P1 crosstalk via NF-B activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis,
Biochemical and Biophysical Research Communications, Vol.490, No.4, 1274-1281, 2017.

(要約): Enhanced turnover of subchondral trabecular bone is a hallmark of rheumatoid arthritis (RA) and it results from an imbalance between bone resorption and bone formation activities. To investigate the formation and activation of osteoclasts which mediate bone resorption, a Fas-deficient MRL/lpr mouse model which spontaneously develops autoimmune arthritis and exhibits decreased bone mass was studied. Various assays were performed on subchondral trabecular bone of the temporomandibular joint (TMJ) from MRL/lpr mice and MRL+/+ mice. Initially, greater osteoclast production was observed in vitro from bone marrow macrophages obtained from MRL/lpr mice due to enhanced phosphorylation of NF-B, as well as Akt and MAPK, to receptor activator of nuclear factor-B ligand (RANKL). Expression of sphingosine 1-phosphate receptor 1 (S1P1) was also significantly upregulated in the condylar cartilage. S1P1 was found to be required for S1P-induced migration of osteoclast precursor cells and downstream signaling via Rac1. When SN50, a synthetic NF-B-inhibitory peptide, was applied to the MRL/lpr mice, subchondral trabecular bone loss was reduced and both production of osteoclastogenesis markers and sphingosine kinase (Sphk) 1/S1P1 signaling were reduced. Thus, the present results suggest that Fas/S1P1 signaling via activation of NF-B in osteoclast precursor cells is a key factor in the pathogenesis of RA in the TMJ.
(キーワード): Animals / Antigens, CD95 / Arthritis, Rheumatoid / Autoimmunity / Bone Marrow Cells / Bone Resorption / Cell Differentiation / Disease Models, Animal / Female / Gene Expression Regulation / Lysophospholipids / Macrophages / Mice / Mice, Inbred MRL lpr / Mitogen-Activated Protein Kinases / NF-kappa B / Neuropeptides / Osteoclasts / Osteogenesis / Peptides / Phosphotransferases (Alcohol Group Acceptor) / Primary Cell Culture / Proto-Oncogene Proteins c-akt / RANK Ligand / Receptors, Lysosphingolipid / Signal Transduction / Sphingosine / Temporomandibular Joint / rac1 GTP-Binding Protein
(徳島大学機関リポジトリ): ● Metadata: 113368
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2017.07.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28687489; ● Search Scopus @ Elsevier (PMID): 28687489; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2017.07.006

(徳島大学機関リポジトリ: 113368, DOI: 10.1016/j.bbrc.2017.07.006, PubMed: 28687489) 天知良太, 渡邉佳一郎, 泰江章博, 川合暢彦, 堀内信也, 田中栄二 :
歯科矯正用アンカースクリューを用いて上下歯列遠心移動を行った三年保定症例,
中·四国矯正歯科学会雑誌, Vol.29, No.1, 37-48, 2017年.

(徳島大学機関リポジトリ): ● Metadata: 115852

(徳島大学機関リポジトリ: 115852) ODO BAYARSAIKHAN, Nobuhiko Kawai, Hiroyo Mori, Nao Kinouchi, Takeshi Nikawa and Eiji Tanaka :
Effects of co-transfection with myostatin-targeting siRNA and ActRIIB-Fc fusion proein on skeletal muscle growth.,
Journal of Oral Health and Biosciences, Vol.30, No.1, 1-7, 2017.

(徳島大学機関リポジトリ): ● Metadata: 111062
(出版サイトへのリンク): ● Publication site (DOI): 10.20738/johb.30.1_1
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.20738/johb.30.1_1

(徳島大学機関リポジトリ: 111062, DOI: 10.20738/johb.30.1_1) Takashi Izawa, Islamy Rahma Hutami, Hiroki Mori and Eiji Tanaka :
Role of Smad3 and S1P Signaling in Mandibular Condylar Cartilage Homeostasis,
Journal of Bone Research, Vol.5, No.2, 178, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.4172/2572-4916.1000178
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4172/2572-4916.1000178

(DOI: 10.4172/2572-4916.1000178) L Jose Calvo-Gallego, S Maria Commisso, Jaime Domínguez, Eiji Tanaka and Javier Martínez-Reina :
Effect of freezing storage time on the elastic and viscous properties of the porcine TMJ disc.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.71, 314-319, 2017.

(要約): The correct characterisation of the articular disc of the temporomandibular joint (TMJ) is key to study the masticatory biomechanics. For the interval from extraction until testing, freezing is the most used preservation technique for biological tissues, but its influence on their behaviour is still unclear. An important error can be committed in the characterisation of such tissues if freezing has any effect on their mechanical properties. Thus, the aim of this study was to determine whether the freezing storage time causes any change in the mechanical properties of the TMJ discs. To check that, the specimens were stored in a -20°C freezer during different time intervals: 1 day, 1 week, 1 month and 3 months. Fresh specimens, tested right after extraction, were used as the control group. Compressive stress relaxation tests were carried out on the specimens and a quasi-linear viscoelastic (QLV) model was used to fit the experimental curves. A statistical analysis detected significant differences among the groups. Post-hoc tests determined that freezing the specimens more than 30 days may lead to changes in the viscoelastic properties of the tissue.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2017.03.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28390304; ● Summary page in Scopus @ Elsevier: 2-s2.0-85017132566

(DOI: 10.1016/j.jmbbm.2017.03.035, PubMed: 28390304, Elsevier: Scopus) Akihiro Yasue, Hitomi Kono, Munenori Habuta, Tetsuya Bando, Keita Sato, Junji Inoue, Seiichi Oyadomari, Sumihare Noji, Eiji Tanaka and Hideyo Ohuchi :
Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos.,
Scientific Reports, Vol.7, No.1, 2017.

(要約): The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system is a rapid gene-targeting technology that does not require embryonic stem cells. To demonstrate dosage effects of the Pax6 gene on eye formation, we generated Pax6-deficient mice with the CRISPR/Cas system. Eyes of founder embryos at embryonic day (E) 16.5 were examined and categorized according to macroscopic phenotype as class 1 (small eye with distinct pigmentation), class 2 (pigmentation without eye globes), or class 3 (no pigmentation and no eyes). Histologically, class 1 eyes were abnormally small in size with lens still attached to the cornea at E16.5. Class 2 eyes had no lens and distorted convoluted retinas. Class 3 eyes had only rudimentary optic vesicle-like tissues or histological anophthalmia. Genotyping of neck tissue cells from the founder embryos revealed somatic mosaicism and allelic complexity for Pax6. Relationships between eye phenotype and genotype were developed. The present results demonstrated that development of the lens from the surface ectoderm requires a higher gene dose of Pax6 than development of the retina from the optic vesicle. We further anticipate that mice with somatic mosaicism in a targeted gene generated by CRISPR/Cas-mediated genome editing will give some insights for understanding the complexity in human congenital diseases that occur in mosaic form.
(徳島大学機関リポジトリ): ● Metadata: 112365
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-017-00088-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28246397; ● Search Scopus @ Elsevier (PMID): 28246397; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-017-00088-w

(徳島大学機関リポジトリ: 112365, DOI: 10.1038/s41598-017-00088-w, PubMed: 28246397) Akiko Mino, Takashi Izawa, Takehiro Shinohara, Hiroki Mori, Akihiro Yasue, Shuhei Tomita and Eiji Tanaka :
Roles of hypoxia inducible factor-1α in the temporomandibular joint.,
Archives of Oral Biology, Vol.73, 274-281, 2017.

(要約): Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease characterized by permanent cartilage loss. Articular cartilage is maintained in a low-oxygen environment. The chondrocyte response to hypoxic conditions involves expression of hypoxia inducible factor 1α (HIF-1α), which induces chondrocytes to increase expression of vascular endothelial growth factor (VEGF). Here, we investigated the role of HIF-1α in mechanical load effects on condylar cartilage and subchondral bone in heterozygous HIF-1α-deficient mice (HIF-1α(+/-)). Mechanical stress was applied to the TMJ of C57BL/6NCr wild-type (WT) and HIF-1α(+/-) mice with a sliding plate for 10 days. Histological analysis was performed by HE staining, Safranin-O/Fast green staining, and immunostaining specific for articular cartilage homeostasis. HIF-1α(+/-) mice had thinner cartilage and smaller areas of proteoglycan than WT controls, without and with mechanical stress. Mechanical stress resulted in prominent degenerative changes with increased expression of HIF-1α, VEGF, and the apoptosis factor cleaved Caspase-3 in condylar cartilage. Our results indicate that HIF-1α may be important for articular cartilage homeostasis and protective against articular cartilage degradation in the TMJ under mechanical stress condition, therefore HIF-1α could be an important new therapeutic target in TMJ-OA.
(徳島大学機関リポジトリ): ● Metadata: 110094
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2016.10.028
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27816790; ● Search Scopus @ Elsevier (PMID): 27816790; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2016.10.028

(徳島大学機関リポジトリ: 110094, DOI: 10.1016/j.archoralbio.2016.10.028, PubMed: 27816790) ODO BAYARSAIKHAN, Nobuhiko Kawai, Hiroyo Mori, Nao Kinouchi, Takeshi Nikawa and Eiji Tanaka :
Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size.,
Journal of Nutritional Science and Vitaminology, Vol.63, No.4, 244-248, 2017.

(要約): Myostatin, a member of the TGF- superfamily, is a negative regulator of skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB). The soluble ligand-binding domain of ActRIIB fused to the Fc domain of IgG (ActRIIB-Fc) potently binds and inhibits TGF- family members in muscle, leading to rapid and marked muscle growth. The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal muscle as a potential treatment of atrophic myopathies. Eleven-week-old, male C57BL/6 mice were injected with atelocollagen (ATCOL)-mediated Mstn-siRNA with/without ActRIIB-Fc locally into the masseter muscle twice a week. Inhibition of myostatin function by the combination of Mstn-siRNA and ActRIIB-Fc increased muscle weight and myofibril size in murine masseter muscle. Real-time RT-PCR analysis revealed significant downregulation of myostatin mRNA expression in both the Mstn-siRNA-treated and the combination treatment group. Furthermore, myogenin mRNA expression was upregulated in the combination treatment group, while MuRF-1 and Atrogin-1 mRNA expression was downregulated compared to administration of each compound alone. These findings suggest that double inhibition of myostatin is a potentially useful treatment strategy to increase muscle mass and fiber size and could be a useful treatment of patients with various muscle atrophies, including muscular dystrophy.
(徳島大学機関リポジトリ): ● Metadata: 114288
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.63.244
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28978871; ● Search Scopus @ Elsevier (PMID): 28978871; ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.63.244

(徳島大学機関リポジトリ: 114288, DOI: 10.3177/jnsv.63.244, PubMed: 28978871) Takashi Izawa, Rieko Arakaki, Hiroki Mori, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka and Naozumi Ishimaru :
The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis.,
The Journal of Immunology, Vol.197, No.12, 4639-4650, 2016.

(要約): The aryl hydrocarbon receptor (AhR) pathway plays a key role in receptor activator of NF-κB ligand (RANKL)-mediated osteoclastogenesis. However, the mechanism underlying the regulation of AhR expression in osteoclasts and the signaling pathway through which AhR controls osteoclastogenesis remain unclear. We found that the expression of AhR in bone marrow-derived osteoclasts was upregulated by RANKL at an earlier stage than was the expression of signature osteoclast genes such as those encoding cathepsin K and NFAT, cytoplasmic, calcineurin-dependent 1. In response to RANKL, bone marrow macrophages isolated from AhR(-/-) mice exhibited impaired phosphorylation of Akt and MAPK as well as NF-κB, whereas their response to M-CSF remained unchanged. Osteoclast differentiation mediated by the AhR signaling pathway was also regulated in an RANKL/c-Fos-dependent manner. Furthermore, ligand activation of AhR by the smoke toxin benzo[a]pyrene accelerated osteoclast differentiation in a receptor-dependent manner, and AhR-dependent regulation of mitochondrial biogenesis in osteoclasts was observed. Moreover, AhR(-/-) mice exhibited impaired bone healing with delayed endochondral ossification. Taken together, the present results suggest that the RANKL/AhR/c-Fos signaling axis plays a critical role in osteoclastogenesis, thereby identifying the potential of AhR in treating pathological, inflammatory, or metabolic disorders of the bone.
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/jimmunol.1600822
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27849171; ● Search Scopus @ Elsevier (PMID): 27849171; ● Search Scopus @ Elsevier (DOI): 10.4049/jimmunol.1600822

(DOI: 10.4049/jimmunol.1600822, PubMed: 27849171) Silvia Naomi Mitsui Akagi, Akihiro Yasue, Kiyoshi Masuda, Takuya Naruto, Yoshiyuki Minegishi, Seiichi Oyadomari, Sumihare Noji, Issei Imoto and Eiji Tanaka :
Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development.,
Scientific Reports, Vol.6, 2016.

(要約): Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified a novel frameshift mutation of the highly conserved C-terminal domain of MSX1, known as Msx homology domain 6 (MH6), in a Japanese family with non-syndromic tooth agenesis. To investigate the importance of MH6 in tooth development, Msx1 was targeted in mice with CRISPR/Cas system. Although heterozygous MH6 disruption did not alter craniofacial development, homozygous mice exhibited agenesis of lower incisors with or without cleft palate at E16.5. In addition, agenesis of the upper third molars and the lower second and third molars were observed in 4-week-old mutant mice. Although the upper second molars were present, they were abnormally small. These results suggest that the C-terminal domain of MSX1 is important for tooth and palate development, and demonstrate that that CRISPR/Cas system can be used as a tool to assess causality of human disorders in vivo and to study the importance of conserved domains in genes.
(徳島大学機関リポジトリ): ● Metadata: 110156
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/srep38398
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27917906; ● Summary page in Scopus @ Elsevier: 2-s2.0-85001945906

(徳島大学機関リポジトリ: 110156, DOI: 10.1038/srep38398, PubMed: 27917906, Elsevier: Scopus) Takehiro Shinohara, Takashi Izawa, Akiko Mino, Hiroki Mori, Akihiko Iwasa, Toshihiro Inubushi, Yu Yamaguchi and Eiji Tanaka :
Hyaluronan metabolism in overloaded temporomandibular joint,
Journal of Oral Rehabilitation, Vol.43, No.12, 921-928, 2016.

(要約): This study aimed to examine hyaluronan (HA) metabolism in relation to the onset and progression of temporomandibular joint osteoarthritis (TMJ-OA) induced by mechanical overloading. Two-month-old and 6-month-old C57BL/6N mice were divided into experimental and untreated control groups (n = 5/group). A sliding plate was attached to the maxillary incisors of the experimental mice for 10 days to overload the condylar cartilage in TMJ. In experimental group, profound cartilage degradation was detected in haematoxylin-eosin, Safranin-O-Fast Green-stained sections. It was also shown that the cartilage degradation was greater in older mice in both the control and the experimental groups. The number of HABP-positive cells was decreased by mechanical overloading and with age. The reduction of HA expression was correlated with the progression of cartilage degradation induced by mechanical overloading. The absolute quantification of the mRNA expression related to HA synthesis and HA degradation was also performed in each group. The mRNA expression levels of HA synthase (HAS) 2 and 3 were lower in the experimental group compared with the control group in the younger mice. In contrast, the mRNA expression levels of the HA degradation gene, HYAL2 and KIAA1199, were higher in the experimental group compared with the control group in the older mice. Thus, mechanical overload differently affected the balance of HA degradation and HA synthesis in the older and younger mice, respectively. In conclusion, mechanical overloading affects HA metabolism and it might initiate or amplify the condylar cartilage degradation.
(徳島大学機関リポジトリ): ● Metadata: 110120
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.12443
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27627706; ● Summary page in Scopus @ Elsevier: 2-s2.0-84994718053

(徳島大学機関リポジトリ: 110120, DOI: 10.1111/joor.12443, PubMed: 27627706, Elsevier: Scopus) Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Shingen Nakamura, Derek Hanson, Keiichiro Watanabe, Shiroh Fujii, Hirokazu Miki, Kumiko Kagawa, Masami Iwasa, Itsuro Endo, Takeshi Kondo, Sumiko Yoshida, Ken-ichi Aihara, Kiyoe Kurahashi, Yoshiaki Kuroda, Hideaki Horikawa, Eiji Tanaka, Masahiro Abe and Toshio Matsumoto :
A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration.,
Oncotarget, Vol.7, No.43, 70447-70461, 2016.

(要約): Myeloma (MM) cells and osteoclasts are mutually interacted to enhance MM growth while creating acidic bone lesions. Here, we explored acid sensing of MM cells and its role in MM cell response to acidic conditions. Acidic conditions activated the PI3K-Akt signaling in MM cells while upregulating the pH sensor transient receptor potential cation channel subfamily V member 1 (TRPV1) in a manner inhibitable by PI3K inhibition. The acid-activated PI3K-Akt signaling facilitated the nuclear localization of the transcription factor Sp1 to trigger the expression of its target genes, including TRPV1 and HDAC1. Consistently, histone deacetylation was enhanced in MM cells in acidic conditions, while repressing a wide variety of genes, including DR4. Indeed, acidic conditions deacetylated histone H3K9 in a DR4 gene promoter and curtailed DR4 expression in MM cells. However, inhibition of HDAC as well as either Sp1 or PI3K was able to restore DR4 expression in MM cells suppressed in acidic conditions. These results collectively demonstrate that acid activates the TRPV1-PI3K-Akt-Sp1 signaling in MM cells while inducing HDAC-mediated gene repression, and suggest that a positive feedback loop between acid sensing and the PI3K-Akt signaling is formed in MM cells, leading to MM cell response to acidic bone lesions.
(徳島大学機関リポジトリ): ● Metadata: 113048
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.11927
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27626482; ● Search Scopus @ Elsevier (PMID): 27626482; ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.11927

(徳島大学機関リポジトリ: 113048, DOI: 10.18632/oncotarget.11927, PubMed: 27626482) Yohei Nakayama, Sari Matsui, Keisuke Noda, Mizuho Yamazaki, Yasunobu Iwai, Hiroyoshi Matsumura, Takashi Izawa, Eiji Tanaka, Bernhard Ganss and Yorimasa Ogata :
Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFb1 in mouse gingival epithelial cells,
Apoptosis, Vol.21, No.10, 1057-1070, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10495-016-1279-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27502207; ● Search Scopus @ Elsevier (PMID): 27502207; ● Search Scopus @ Elsevier (DOI): 10.1007/s10495-016-1279-5

(DOI: 10.1007/s10495-016-1279-5, PubMed: 27502207) Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Correction: Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.,
PLoS ONE, Vol.11, No.8, e0162032, 2016.

(要約): [This corrects the article DOI: 10.1371/journal.pone.0154107.].
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0162032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27560140; ● Search Scopus @ Elsevier (PMID): 27560140; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0162032

(DOI: 10.1371/journal.pone.0162032, PubMed: 27560140) Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shingo Kuroda and Eiji Tanaka :
Long-term stability of conservative orthodontic treatment in a patient with temporomandibular joint disorder.,
Journal of Orthodontic Science, Vol.5, No.3, 104-108, 2016.

(要約): This article reports the orthodontic treatment of a 20-year-old patient with dental crowding and temporomandibular joint disorders (TMDs). The patient presented moderate anterior crowding with a Class I molar relationship and masticatory disturbance in the mandibular position induced by previous splint therapy. Orthodontic treatment with multi-bracket appliance was initiated to correct the anterior crowding in both dental arches, after the extraction of first premolars and third molars, and also to maintain the splint-induced position of the condyles. After 26 months of treatment, an acceptable occlusion was achieved without any TMD symptoms. After 18-month retention, flattening on the right condyle was observed, possibly as an adaptative remodeling. After 16-year retention period, the occlusion was maintained without recurrence of any TMD symptoms, indicating a long-term stability of occlusion and temporomandibular joint (TMJ) components. Our results suggest the possibility of compromised treatment in patients with TMD to achieve a long-term stability in occlusion and TMJ function.
(徳島大学機関リポジトリ): ● Metadata: 113519
(出版サイトへのリンク): ● Publication site (DOI): 10.4103/2278-0203.186168
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27556023; ● Search Scopus @ Elsevier (PMID): 27556023; ● Search Scopus @ Elsevier (DOI): 10.4103/2278-0203.186168

(徳島大学機関リポジトリ: 113519, DOI: 10.4103/2278-0203.186168, PubMed: 27556023) Shingo Kuroda, Natsuko Hichijo, Minami Sato, Akiko Mino, Nagato Tamamura, Mitsuhiro Iwata and Eiji Tanaka :
Long-term stability of maxillary group distalization with interradicular miniscrews in a patient with a Class II Division 2 malocclusion.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.149, No.6, 912-922, 2016.

(要約): We successfully treated a Class II Division 2 patient with maxillary group distalization using interradicular miniscrews. A woman, aged 28 years 11 months, had a convex profile and an excessive overjet caused by a skeletal Class II jaw-base relationship. After leveling and alignment, titanium miniscrews were obliquely implanted between the maxillary second premolar and first molar. To distalize the maxillary dentition, nickel-titanium closing coil springs with a 2-N load were placed between the screws and the hooks on the archwire. After 28 months of active orthodontic treatment, a proper facial profile and an acceptable occlusion were achieved with a 4-mm distalization of the maxillary dentition. The resultant occlusion was stable throughout a 5-year retention period. Interradicular miniscrews were useful to distalize the maxillary dentition for correcting a Class II malocclusion. This new strategy, group distalization with miniscrews, can make the treatment simpler with greater predictability.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2015.07.045
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27242002; ● Search Scopus @ Elsevier (PMID): 27242002; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2015.07.045

(DOI: 10.1016/j.ajodo.2015.07.045, PubMed: 27242002) Eiji Tanaka, Chieko Shiota, Minami Sato, Shinji Fujihara, Toshiro Kondoh and Shingo Kuroda :
Unilateral mandibular condylar osteochondroma treated with ipsilateral condylectomy and contralateral ramus osteotomy.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.149, No.5, 740-750, 2016.

(要約): We successfully treated a 32-year-old woman who had facial asymmetry and unilateral mandibular condylar osteochondroma using ipsilateral mandibular condylectomy and contralateral ramus osteotomy. Mirror image analysis with a noncontact 3-dimensional image scanner showed that the soft tissue on the deviated side was protruded more than 5.50 mm compared with the nondeviated side. The patient was diagnosed as having facial asymmetry with a skeletal Class III jaw-base relationship caused by unilateral mandibular condylar osteochondroma. After 18 months of preoperative orthodontic treatment, an ipsilateral condylectomy and a contralateral sagittal split ramus osteotomy were performed. As the result of postoperative orthodontic treatment for 20 months, an ideal occlusion with a Class I molar relationship and an adequate interincisal relationship was achieved. Facial asymmetry and mandibular protrusion were dramatically improved, and the total differences between the deviated and nondeviated sides were decreased to less than 1.11 mm. The acceptable occlusion and the symmetric face were maintained throughout the 1-year retention period. Our results indicated stability after condylectomy without condylar reconstruction in a patient with unilateral condylar osteochondroma.
(徳島大学機関リポジトリ): ● Metadata: 114280
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2015.05.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27131256; ● Search Scopus @ Elsevier (PMID): 27131256; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2015.05.035

(徳島大学機関リポジトリ: 114280, DOI: 10.1016/j.ajodo.2015.05.035, PubMed: 27131256) Eva Barrientos, Fernández Pelayo, Eiji Tanaka, Jesús María Lamela-Rey and Alfonso Fernández-Canteli :
Dynamic and stress relaxation properties of the whole porcine temporomandibular joint disc under compression.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.57, 109-115, 2016.

(要約): In this study, the dynamic and static compressive properties of the whole porcine temporomandibular joint (TMJ) disc were investigated. The aim of the study was to develop a new simple method for the evaluation of joint viscoelasticity, enabling examination of the load-bearing capacity and joint flexibility of the entire disc. For the experiments, a novel testing fixture that reproduces the condylar and fossa surfaces of the TMJ was developed to replicate TMJ disc geometry. Ten porcine discs were used in the experiments. Each disc was dissected from the TMJ and sinusoidal compressive strain was applied to obtain the storage and loss moduli. Static strain control tests were carried out to obtain the relaxation modulus. The result of static and dynamic tests indicated that the whole disc presented viscoelastic behavior under compression. Storage and loss moduli increased with frequency and the relaxation modulus decreased over time. The loss tangent showed less frequency dependence, with values ranging from 0.2 to 0.3, suggesting that the viscous properties of the disc cannot be neglected. These results provide a better understanding of whole disc mechanical compression behavior under realistic TMJ working conditions.
(徳島大学機関リポジトリ): ● Metadata: 114279
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2015.12.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26708739; ● Search Scopus @ Elsevier (PMID): 26708739; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2015.12.003

(徳島大学機関リポジトリ: 114279, DOI: 10.1016/j.jmbbm.2015.12.003, PubMed: 26708739) Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis,
PLoS ONE, Vol.11, No.4, e0154107, 2016.

(要約): Temporomandibular joint osteoarthritis (TMJ-OA) is characterized by progressive degradation of cartilage and changes in subchondral bone. It is also one of the most serious subgroups of temporomandibular disorders. Rebamipide is a gastroprotective agent that is currently used for the treatment of gastritis and gastric ulcers. It scavenges reactive oxygen radicals and has exhibited anti-inflammatory potential. The aim of this study was to investigate the impact of rebamipide both in vivo and in vitro on the development of cartilage degeneration and osteoclast activity in an experimental murine model of TMJ-OA, and to explore its mode of action. Oral administration of rebamipide (0.6 mg/kg and 6 mg/kg) was initiated 24 h after TMJ-OA was induced, and was maintained daily for four weeks. Rebamipide treatment was found to attenuate cartilage degeneration, to reduce the number of apoptotic cells, and to decrease the expression levels of matrix metalloproteinase-13 (MMP-13) and inducible nitric oxide synthase (iNOS) in TMJ-OA cartilage in a dose-dependent manner. Rebamipide also suppressed the activation of transcription factors (e.g., NF-κB, NFATc1) and mitogen-activated protein kinases (MAPK) by receptor activator of nuclear factor kappa-B ligand (RANKL) to inhibit the differentiation of osteoclastic precursors, and disrupted the formation of actin rings in mature osteoclasts. Together, these results demonstrate the inhibitory effects of rebamipide on cartilage degradation in experimentally induced TMJ-OA. Furthermore, suppression of oxidative damage, restoration of extracellular matrix homeostasis of articular chondrocytes, and reduced subchondral bone loss as a result of blocked osteoclast activation suggest that rebamipide is a potential therapeutic strategy for TMJ-OA.
(徳島大学機関リポジトリ): ● Metadata: 112307
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0154107
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27123995; ● Search Scopus @ Elsevier (PMID): 27123995; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0154107

(徳島大学機関リポジトリ: 112307, DOI: 10.1371/journal.pone.0154107, PubMed: 27123995) Natsuko Hichijo, Shingo Kuroda, Chieko Shiota, Teppei Watanabe and Eiji Tanaka :
Clinical application of a 3-dimensional morphometric apparatus for diagnosis and treatment of a Class III patient with facial asymmetry: A pilot study.,
Orthodontic Waves, Vol.75, No.1, 18-22, 2016.

(徳島大学機関リポジトリ): ● Metadata: 113520
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.odw.2015.08.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84940056193

(徳島大学機関リポジトリ: 113520, DOI: 10.1016/j.odw.2015.08.001, Elsevier: Scopus) MANSJUR KARIMA QURNIA, Shingo Kuroda, Takashi Izawa, Yuichi Maeda, Minami Sato, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka :
The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones.,
Annals of Biomedical Engineering, 2016.

(要約): Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with PTH (1-34) and LIPUS on fracture healing in ovariectomized (OVX) rats. Thirty-two, 12-week-old female Sprague-Dawley rats were OVX to induce osteoporosis. After 12 weeks, the rats underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n = 8 for each): control group as placebo, PTH group, LIPUS group, and combined group. PTH group had PTH administration at a dose of 30 μg/kg/day for 3 days/week for 6 weeks. LIPUS group received ultrasound 5 days/week for 20 min/day for 6 weeks and combined group had both PTH administration and LIPUS exposure for 6 weeks. Fracture healing was observed weekly by anteroposterior radiography and micro-CT. Five weeks after the fracture, the tibia were harvested to permit histological assessments and at week 6, for mechanical property of the fracture callus. Micro-CT showed that the PTH and combined groups exhibited significantly higher BMD and trabecular bone integrity than control group at weeks 4-6. Radiography, fracture healing score and mean callus area indicated that the combined group revealed better healing processes than the individual groups. Mechanically, bending moment to failure was significantly higher in LIPUS, PTH and combined groups than in control group. These data suggest that the combined treatment of PTH and LIPUS have been shown to accelerate fracture bone healing and enhance bone properties rather than single agent therapy, and may be considered as a treatment remedy for fracture healing in postmenopausal osteoporosis.
(徳島大学機関リポジトリ): ● Metadata: 109959
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-015-1533-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26795976; ● Summary page in Scopus @ Elsevier: 2-s2.0-84955254616

(徳島大学機関リポジトリ: 109959, DOI: 10.1007/s10439-015-1533-y, PubMed: 26795976, Elsevier: Scopus) Hiroki Mori, Takashi Izawa and Eiji Tanaka :
Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.,
The American Journal of Pathology, Vol.185, No.10, 2742-2756, 2015.

(徳島大学機関リポジトリ): ● Metadata: 109705
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajpath.2015.06.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26272361; ● Search Scopus @ Elsevier (PMID): 26272361; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajpath.2015.06.015

(徳島大学機関リポジトリ: 109705, DOI: 10.1016/j.ajpath.2015.06.015, PubMed: 26272361) Minami Sato, Shingo Kuroda, MANSJUR KARIMA QURNIA, KHALIUNAA GANZORIG, Kumiko Nagata, Shinya Horiuchi, Toshihiro Inubushi, Yoshiko Yamamura, Masayuki Azuma and Eiji Tanaka :
Low-intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis.,
Arthritis Research & Therapy, Vol.17, 2015.

(要約): TNF-α stimulation of NS-SV-AC and NS-SV-DC cells resulted in a significant decrease in cell number and net fluid secretion rate (p < 0.01), whereas LIPUS treatment abolished them (p < 0.05). The expression changes of AQP5 and TNF-α were also inhibited in LIPUS treatment by blocking the NF-κB pathway. Furthermore, we found that mRNA expression of A20, a negative feedback regulator, was significantly increased by LIPUS treatment after TNF-α or interleukin 1β stimulation (NS-SV-AC, p < 0.01; NS-SV-DC, p < 0.05). In vivo LIPUS exposure to MRL/lpr mice exhibited a significant increase in both salivary flow and AQP5 expression by reducing inflammation in salivary glands (p < 0.01).
(徳島大学機関リポジトリ): ● Metadata: 109706
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13075-015-0798-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26445930; ● Search Scopus @ Elsevier (PMID): 26445930; ● Search Scopus @ Elsevier (DOI): 10.1186/s13075-015-0798-8

(徳島大学機関リポジトリ: 109706, DOI: 10.1186/s13075-015-0798-8, PubMed: 26445930) Yuichi Maeda, Shingo Kuroda, KHALIUNAA GANZORIG, Wazen Rima, Nanci Antonio and Eiji Tanaka :
Histomorphometric analysis of overloading on palatal tooth movement into the maxillary sinus,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.148, No.3, 423-430, 2015.

(要約): In the 10-g load group, the amount of tooth movement increased dramatically between days 5 and 7 and increased gradually thereafter. Tooth movement at days 5 and 7 was significantly lower in the 30-g-load group than in the 10-g load group; however, the total tooth movement at 14 days was similar in the 2 groups. An orthodontic load of 30 g stimulated bone formation on the sinus wall, but bone resorption on the periodontal ligament side was delayed because of hyalinization, which means that strong force application did not accelerate tooth movement. Moreover, some root resorption was induced by the excessive force.
(徳島大学機関リポジトリ): ● Metadata: 109481
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2015.04.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26321340; ● Summary page in Scopus @ Elsevier: 2-s2.0-84941345522

(徳島大学機関リポジトリ: 109481, DOI: 10.1016/j.ajodo.2015.04.032, PubMed: 26321340, Elsevier: Scopus) 篠原丈裕, 渡邉佳一郎, 森浩喜, 井澤俊, 堀内信也, 黒田晋吾, 谷本幸太郎, 田中栄二 :
顎関節内障を有する骨格性下顎前突症に対する矯正歯科治療の一治験例,
中·四国矯正歯科学会雑誌, Vol.27, No.1, 39-48, 2015年. 徳永律子, 黒田晋吾, 三野彰子, 七條なつ子, 田中栄二 :
抜歯による矯正歯科治療の後戻りに対して歯科矯正用アンカースクリューを用いて再治療を行った症例,
中·四国矯正歯科学会雑誌, Vol.27, No.1, 31-38, 2015年. 渡辺亜希, 加来真人, 角明美, 丹根一夫, 谷本幸太郎, 田中栄二 :
上顎小臼歯の先天性欠損部に下顎小臼歯の移植を行った切端咬合の一治療例,
中·四国矯正歯科学会雑誌, Vol.27, No.1, 23-30, 2015年. Natsuko Hichijo, Eiji Tanaka, Nobuhiko Kawai, J Ruijven Leo van and J Geerling E Langenbach :
Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics.,
PLoS ONE, Vol.10, No.6, 2015.

(要約): Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
(徳島大学機関リポジトリ): ● Metadata: 109704
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0129290
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26062027; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936797805

(徳島大学機関リポジトリ: 109704, DOI: 10.1371/journal.pone.0129290, PubMed: 26062027, Elsevier: Scopus) Namhee Kim, Tetsuro Yoshimaru, Yi-An Chen, Taisuke Matsuo, Masato Komatsu, Yasuo Miyoshi, Eiji Tanaka, Mitsunori Sasa, Kenji Mizuguchi and Toyomasa Katagiri :
BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.,
PLoS ONE, Vol.10, No.6, 2015.

(要約): We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells. However, little is known regarding the mechanism by which BIG3 inhibits the nuclear translocation of PHB2 into breast cancer cells. Here, we report that BIG3 blocks the estrogen (E2)-dependent nuclear import of PHB2 via the karyopherin alpha (KPNA) family in breast cancer cells. We found that overexpressed PHB2 interacted with KPNA1, KPNA5, and KPNA6, thereby leading to the E2-dependent translocation of PHB2 into the nuclei of breast cancer cells. More importantly, knockdown of each endogenous KPNA by siRNA caused a significant inhibition of E2-dependent translocation of PHB2 in BIG3-depleted breast cancer cells, thereby enhancing activation of estrogen receptor alpha (ER). These data indicated that BIG3 may block the KPNAs (KPNA1, KPNA5, and KPNA6) binding region(s) of PHB2, thereby leading to inhibition of KPNAs-mediated PHB2 nuclear translocation in the presence of E2 in breast cancer cells. Understanding this regulation of PHB2 nuclear import may provide therapeutic strategies for controlling E2/ER signals in breast cancer cells.
(徳島大学機関リポジトリ): ● Metadata: 109497
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0127707
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052702; ● Summary page in Scopus @ Elsevier: 2-s2.0-84936761474

(徳島大学機関リポジトリ: 109497, DOI: 10.1371/journal.pone.0127707, PubMed: 26052702, Elsevier: Scopus) J Adam Mellott, Keerthana Devarajan, E Heather Shinogle, S David Moore, Zsolt Talata, S Jennifer Laurence, Laird M Forrest, Sumihare Noji, Eiji Tanaka, Hinrich Staecker and S Michael Detamore :
Nonviral Reprogramming of Human Wharton's Jelly Cells Reveals Differences Between ATOH1 Homologues.,
Tissue Engineering. Part A, Vol.21, No.11-12, 1795-1809, 2015.

(要約): The transcription factor atonal homolog 1 (ATOH1) has multiple homologues that are functionally conserved across species and is responsible for the generation of sensory hair cells. To evaluate potential functional differences between homologues, human and mouse ATOH1 (HATH1 and MATH-1, respectively) were nonvirally delivered to human Wharton's jelly cells (hWJCs) for the first time. Delivery of HATH1 to hWJCs demonstrated superior expression of inner ear hair cell markers and characteristics than delivery of MATH-1. Inhibition of HES1 and HES5 signaling further increased the atonal effect. Transfection of hWJCs with HATH1 DNA, HES1 siRNA, and HES5 siRNA displayed positive identification of key hair cell and support cell markers found in the cochlea, as well as a variety of cell shapes, sizes, and features not native to hair cells, suggesting the need for further examination of other cell types induced by HATH1 expression. In the first side-by-side evaluation of HATH1 and MATH-1 in human cells, substantial differences were observed, suggesting that the two atonal homologues may not be interchangeable in human cells, and artificial expression of HATH1 in hWJCs requires further study. In the future, this line of research may lead to engineered systems that would allow for evaluation of drug ototoxicity or potentially even direct therapeutic use.
(出版サイトへのリンク): ● Publication site (DOI): 10.1089/ten.TEA.2014.0340
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25760435; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930157274

(DOI: 10.1089/ten.TEA.2014.0340, PubMed: 25760435, Elsevier: Scopus) Chieko Shiota, Tomoki Abe, Nobuhiko Kawai, Ayako Ohno, Shigetada Teshima-Kondo, Hiroyo Mori, Junji Terao, Eiji Tanaka and Takeshi Nikawa :
Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes.,
Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 188-194, 2015.

(要約): Muscle atrophy is a complex process that occurs as a consequence of various stress events. Muscle atrophy-associated genes (atrogenes) such as atrogin-1/MAFbx and MuRF-1 are induced early in the atrophy process, and the increase in their expression precedes the loss of muscle weight. Although antioxidative nutrients suppress atrogene expression in skeletal muscle cells, the inhibitory effects of flavonoids on inflammation-induced atrogin-1/MAFbx expression have not been clarified. Here, we investigated the inhibitory effects of flavonoids on lipopolysaccharide (LPS)-induced atrogin-1/MAFbx expression. We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes. Two major flavones, apigenin and luteolin, displayed potent inhibitory effects on atrogin-1/MAFbx expression. The pretreatment with apigenin and luteolin significantly prevented the decrease in C2C12 myotube diameter caused by LPS stimulation. Importantly, the pretreatment of LPS-stimulated myoblasts with these flavones significantly inhibited LPS-induced JNK phosphorylation in C2C12 myotubes, resulting in the significant suppression of atrogin-1/MAFbx promoter activity. These results suggest that apigenin and luteolin, prevent LPS-mediated atrogin-1/MAFbx expression through the inhibition of the JNK signaling pathway in C2C12 myotubes. Thus, these flavones, apigenin and luteolin, may be promising agents to prevent LPS-induced muscle atrophy.
(徳島大学機関リポジトリ): ● Metadata: 109398
(出版サイトへのリンク): ● Publication site (DOI): 10.3177/jnsv.61.188
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052151; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930695782

(徳島大学機関リポジトリ: 109398, DOI: 10.3177/jnsv.61.188, PubMed: 26052151, Elsevier: Scopus) KHALIUNAA GANZORIG, Shingo Kuroda, Yuichi Maeda, MANSJUR KARIMA QURNIA, Minami Sato, Kumiko Nagata and Eiji Tanaka :
Low-intensity pulsed ultrasound enhances bone formation around miniscrew implants.,
Archives of Oral Biology, Vol.60, No.6, 902-910, 2015.

(要約): LIPUS enhanced bone formation around Ti and SS MSIs, enhancing the initial stability of MSIs.
(徳島大学機関リポジトリ): ● Metadata: 109480
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2015.02.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25824309; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925857051

(徳島大学機関リポジトリ: 109480, DOI: 10.1016/j.archoralbio.2015.02.014, PubMed: 25824309, Elsevier: Scopus) Eiji Tanaka, Shingo Kuroda, Shinya Horiuchi, Akira Tabata and Tarek El-Bialy :
Low-Intensity Pulsed Ultrasound in Dentofacial Tissue Engineering.,
Annals of Biomedical Engineering, Vol.43, No.4, 871-886, 2015.

(要約): Oral and maxillofacial diseases affect millions of people worldwide and hence tissue engineering can be considered an interesting and clinically relevant approach to regenerate orofacial tissues after being affected by different diseases. Among several innovations for tissue regeneration, low-intensity pulsed ultrasound (LIPUS) has been used extensively in medicine as a therapeutic, operative, and diagnostic tool. LIPUS is accepted to promote bone fracture repair and regeneration. Furthermore, the effect of LIPUS on soft tissues regeneration has been paid much attention, and many studies have performed to evaluate the potential use of LIPUS to tissue engineering soft tissues. The present article provides an overview about the status of LIPUS stimulation as a tool to be used to enhance regeneration/tissue engineering. This review consists of five parts. Part 1 is a brief introduction of the acoustic description of LIPUS and mechanical action. In Part 2, biological problems in dentofacial tissue engineering are proposed. Part 3 explores biologic mechanisms of LIPUS to cells and tissues in living body. In Part 4, the effectiveness of LIPUS on cell metabolism and tissue regeneration in dentistry are summarized. Finally, Part 5 relates the possibility of clinical application of LIPUS in orthodontics. The present review brings out better understanding of the bioeffect of LIPUS therapy on orofacial tissues which is essential to the successful integration of management remedies for tissue regeneration/engineering. To develop an evidence-based approach to clinical management and treatment of orofacial degenerative diseases using LIPUS, we would like to be in full pursuit of LIPUS biotherapy. Still, there are many challenges for this relatively new strategy, but the up to date achievements using it promises to go far beyond the present possibilities.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-015-1274-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25672801; ● Search Scopus @ Elsevier (PMID): 25672801; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-015-1274-y

(DOI: 10.1007/s10439-015-1274-y, PubMed: 25672801) Nobuhiko Kawai, Katsuya Hirasaka, Tasuku Maeda, Marie Haruna, Chieko Shiota, Arisa Ochi, Tomoki Abe, Shohei Kohno, Ayako Ohno, Sigetada Teshima-Kondo, Hiroyo Mori, Eiji Tanaka and Takeshi Nikawa :
Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen.,
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1853, No.5, 873-880, 2015.

(要約): Skeletal muscle atrophy occurs when the rate of protein degradation exceeds that of protein synthesis in various catabolic conditions, such as fasting, disuse, aging, and chronic diseases. Insulin-like growth factor-1 (IGF-1) signaling stimulates muscle growth and suppresses muscle protein breakdown. In atrophied muscles, ubiquitin ligase, Cbl-b, increases and stimulates the ubiquitination and degradation of IRS-1, an intermediate in IGF-1 signaling pathway, resulting in IGF-1 resistance. In this study, we evaluated the efficacy of atelocollagen (ATCOL)-transported anti-ubiquitination oligopeptide (Cblin: Cbl-b inhibitor) (consisting of tyrosine phosphorylation domain of IRS-1) in starved C2C12 myotubes. The amount of IRS-1 protein was lower in starved versus unstarved myotubes. The Cblin-ATCOL complex inhibited IRS-1 degradation in a concentration-dependent manner. Myotubes incubated with Cblin-ATCOL complex showed significant resistance to starvation-induced atrophy (p<0.01). Furthermore, the Cblin-ATCOL complex significantly inhibited any decrease in Akt phosphorylation (p<0.01) and localization of FOXO3a to the nucleus in starved myotubes. These results suggest that Cblin prevented starvation-induced C2C12 myotube atrophy by maintaining the IGF-1/Akt/FOXO signaling. Therefore, attachment of anti-ubiquitination oligopeptide, Cblin, to ATCOL enhances its delivery to myotubes and could be a potentially effective strategy in the treatment of atrophic myopathies.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbamcr.2015.01.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25667084; ● Summary page in Scopus @ Elsevier: 2-s2.0-84923091632

(DOI: 10.1016/j.bbamcr.2015.01.024, PubMed: 25667084, Elsevier: Scopus) Akihiko Iwasa, Rieko Arakaki, Naoko Honma, Aya Ushio, Akiko Yamada, Tomoyuki Kondo, Emi Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka, Noriko Yoshimura, Nobuhiro Harada, Yoshio Hayashi and Naozumi Ishimaru :
Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.,
The American Journal of Pathology, Vol.185, No.1, 151-161, 2015.

(要約): Several autoimmune diseases are known to develop in postmenopausal women. However, the mechanism by which estrogen deficiency influences autoimmunity is unknown. Aromatase is an enzyme that converts androgens to estrogens. Herein, we used female aromatase gene knockout (ArKO) mice as a model of estrogen deficiency to investigate the molecular mechanism that underlies the onset and development of autoimmunity. Histological analyses showed that inflammatory lesions in the lacrimal and salivary glands of ArKO mice increased with age. Adoptive transfer of spleen cells or bone marrow cells from ArKO mice into recombination activating gene 2 knockout mice failed to induce the autoimmune lesions. Expression of mRNA encoding proinflammatory cytokines and monocyte chemotactic protein-1 increased in white adipose tissue of ArKO mice and was significantly higher than that in wild-type mice. Moreover, an increased number of inflammatory M1 macrophages was observed in white adipose tissue of ArKO mice. A significantly increased monocyte chemotactic protein-1 mRNA expression of the salivary gland tissue in ArKO was found together with adiposity. Furthermore, the autoimmune lesions in a murine model of Sjögren syndrome were exacerbated by administration of an aromatase inhibitor. These results suggest that aromatase may play a key role in the pathogenesis of Sjögren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage.
(徳島大学機関リポジトリ): ● Metadata: 113532
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajpath.2014.09.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25447050; ● Summary page in Scopus @ Elsevier: 2-s2.0-84918779178

(徳島大学機関リポジトリ: 113532, DOI: 10.1016/j.ajpath.2014.09.006, PubMed: 25447050, Elsevier: Scopus) Y Asakawa-Tanne, S Su, R Kunimatsu, N Hirose, T Mitsuyoshi, Y Okamoto, Eiji Tanaka, Kazuo Tanne and Kotaro Tanimoto :
Effects of enzymatic degradation after loading in temporomandibular joint.,
Journal of Dental Research, Vol.94, No.2, 337-343, 2014.

(要約): Synovial fluid of the joint decreases friction between the cartilage surfaces and reduces cartilage wear during articulation. Characteristic changes of synovial fluid have been shown in patients with osteoarthritis (OA) in the temporomandibular joint (TMJ). OA is generally considered to be induced by excessive mechanical stress. However, whether the changes in synovial fluid precede the mechanical overloading or vice versa remains unclear. In the present study, our purpose was to examine if the breakdown of joint lubrication affects the frictional properties of mandibular condylar cartilage and leads to subsequent degenerative changes in TMJ. We measured the frictional coefficient in porcine TMJ by a pendulum device after digestion with hyaluronidase (HAase) or trypsin. Gene expressions of interleukin-1 (IL-1), cyclooxygenase-2 (COX-2), matrix metalloproteinases (MMPs), type II collagen, and histology were examined after prolonged cyclic loading by an active pendulum system. The results showed that the frictional coefficient increased significantly after HAase (35%) or trypsin (74%) treatment. Gene expression of IL-1, COX-2, and MMPs-1, -3, and -9 increased significantly in enzyme-treated TMJs after cyclic loading. The increase in the trypsin-treated group was greater than that in the HAase-treated group. Type II collagen expression was reduced in both enzyme-treated groups. Histology revealed surface fibrillation and increased MMP-1 in the trypsin-treated group, as well as increased IL-1 in both enzyme-treated groups after cyclic loading. The findings demonstrated that the compromised lubrication in TMJ is associated with altered frictional properties and surface wear of condylar cartilage, accompanied by release of pro-inflammatory and matrix degradation mediators under mechanical loading.
(キーワード): Animals / Biomechanical Phenomena / Cartilage, Articular / Collagen Type II / Cyclooxygenase 2 / Friction / Hyaluronoglucosaminidase / Interleukin-1beta / Lubrication / Mandibular Condyle / Matrix Metalloproteinase 1 / Matrix Metalloproteinase 3 / Matrix Metalloproteinase 9 / Osteoarthritis / Stress, Mechanical / Swine / Synovial Fluid / Temporomandibular Joint / Temporomandibular Joint Disorders / Trypsin
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0022034514560588
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25503611; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921328528

(DOI: 10.1177/0022034514560588, PubMed: 25503611, Elsevier: Scopus) Akira Nakajima, Yoshihiro Ito, Eiji Tanaka, Remi Sano, Yoko Karasawa, Masao Maeno, Koichi Iwata, Noriyoshi Shimizu and F. Cgarkes Shuler :
Functional role of TGF-beta receptors during palatal fusion invitro,
Archives of Oral Biology, Vol.59, No.11, 1192-1204, 2014.

(要約): AbstractOBJECTIVE: Reported expression patterns for TGF- receptors (TR-I, -II, and -III) during palatogenesis suggest that they play essential roles in the mechanisms leading to palatal fusion. The purpose of this study was to compare the functions of the three TRs during palatal fusion.METHODS: Using organ culture of mouse palatal shelves, expression levels of TR-I, -II, and -III were suppressed by transfecting the siRNAs siTR-I, -II, and -III, respectively. Phosphorylation of SMAD2 was examined as an indicator of downstream signalling via each TR. Linkage between TGF- signalling and critical events in palatal fusion led to the use of, MMP-13 expression as an outcome measure for the function of the TGF- receptors.RESULTS: The siRNA treatment decreased the expression level of each receptor by more than 85%. When treated with either siTR-I or -II, palatal shelves at E13+72h were not fused, with complete clefting in the anterior and posterior regions. The middle palatal region following treatment with either siTR-I or -II had fusion from one-half or one-third of the palatal region. Treatment with siTR-III resulted in a persistent midline seam of medial edge epithelium (MEE) in the anterior region with islands of persistent MEE in the middle and posterior regions of the midline. Treatment with all three siTRs altered the pattern of SMAD2 phosphorylation. Palatal shelf cultures treated with siTR-I or -II, but not -III, showed altered MMP-13 expression levels.CONCLUSION: The ability to identify and recover MEE and palatal mesenchymal cells during palatal fusion will aid in the evaluation of the different mechanistic events regulated by each TR during palatogenesis.
(キーワード): MMP-13 expression / Palatal development / SMAD2 phosphorylation / TGF- receptor / TGF- signalling / siRNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2014.07.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25105252; ● Search Scopus @ Elsevier (PMID): 25105252; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2014.07.007

(DOI: 10.1016/j.archoralbio.2014.07.007, PubMed: 25105252) Minami Sato, Kumiko Nagata, Shingo Kuroda, Shinya Horiuchi, Tatsuya Nakamura, MANSJUR KARIMA QURNIA, Toshihiro Inubushi and Eiji Tanaka :
Low-Intensity Pulsed Ultrasound Activates Integrin-Mediated Mechanotransduction Pathway in Synovial Cells.,
Annals of Biomedical Engineering, Vol.42, No.10, 2156-2163, 2014.

(要約): Low-intensity pulsed ultrasound (LIPUS) suppresses synovial hyperplasia and synovial cell proliferation characterized for rheumatoid arthritis, but the molecular mechanisms remain unknown. The purpose of this study was to examine the mechanotransduction pathway via the integrin/mitogen-activated protein kinase (MAPK) pathway in LIPUS exposure on the synovial membrane cells. Rabbit knee synovial membrane cell line, HIG-82, was cultured with or without FAK phosphorylation inhibitor, PF-573228. One hour after stimulation with PF-573228, the cells exposed to LIPUS for 20 min or sham exposure. A possible integrin/MAPK pathway was examined by immunofluorescence and Western blotting analysis with antibodies targeting specific phosphorylation sites on intracellular signaling proteins. LIPUS exposure increased phosphorylation of FAK, JNK, ERK, and p38, but the phosphorylation was inhibited by PF-573228. In conclusion, LIPUS exposure might be involved in cell apoptosis and survival of synovial membrane cells via integrin/FAK/MAPK pathway.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-014-1081-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25096496; ● Search Scopus @ Elsevier (PMID): 25096496; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-014-1081-x

(DOI: 10.1007/s10439-014-1081-x, PubMed: 25096496) Erica Hattori-Hara, Silvia Naomi Mitsui Akagi, Hiroyo Mori, Keiji Arafurue, Takuji Kawaoka, Kanji Ueda, Akihiro Yasue, Shingo Kuroda, Harm Jan Koolstra and Eiji Tanaka :
The influence of unilateral disc displacement on stress in the contralateral joint with a normally positioned disc in a human temporomandibular joint: An analytic approach using the finite element method.,
Journal of Cranio-Maxillo-Facial Surgery, Vol.42, 2018-2024, 2014.

(要約): In the unaffected joint of the unilateral DD model, the largest von Mises stress at the start of clenching was predicted in the inferior surface of the disc and increased by 30% during clenching. In the connective tissue the largest stress (1.16 MPa) did not reduce during clenching, in contrast to the (unaffected) joints of the reference model. In the affected joint, the largest stress was predicted in the temporal cartilage throughout clenching. In the surrounding connective tissue, the largest stress (1.42 MPa) hardly changed during clenching indicating no, or negligible, stress relaxation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcms.2014.09.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25458347; ● Search Scopus @ Elsevier (PMID): 25458347; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcms.2014.09.008

(DOI: 10.1016/j.jcms.2014.09.008, PubMed: 25458347) Naoki Abe, Shingo Kuroda, M Furutani and Eiji Tanaka :
Data-based prediction of soft tissue changes after orthognathic surgery: clinical assessment of new simulation software.,
International Journal of Oral and Maxillofacial Surgery, Vol.44, No.1, 90-96, 2014.

(要約): The aim of the present study was to evaluate the accuracy of a novel simulation software package (OrthoForecast) for predicting the soft tissue profile after orthognathic surgery. The study included 15 patients with facial asymmetry (asymmetry group), 15 with a skeletal class II jaw relationship (class II group), and 15 with a skeletal class III jaw relationship (class III group). Twenty-four feature points were digitized, and the distances between points on the predicted and actual postoperative images were compared. Thirty-seven calibrated evaluators also graded the similarity of the predicted images compared to the actual postoperative photographs. Comparisons between the predicted and actual postoperative images revealed that the mean difference between feature points was 3.1 ± 1.4 mm for the frontal images and 2.9 ± 0.8 mm for the lateral images in the asymmetry group; 2.7 ± 0.9 and 2.1 ± 1.6 mm, respectively, in the class II group; and 1.8 ± 1.2 and 1.7 ± 1.0 mm, respectively, in the class III group. More than half of the evaluators assessed the predicted images as similar to the actual postoperative images in all groups. In conclusion, OrthoForecast can be regarded as useful, accurate, and reliable software to predict soft tissue changes after orthognathic surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijom.2014.08.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25220944; ● Search Scopus @ Elsevier (PMID): 25220944; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijom.2014.08.006

(DOI: 10.1016/j.ijom.2014.08.006, PubMed: 25220944) Masahide Inoue, Shingo Kuroda, Akihiro Yasue, Shinya Horiuchi, Hee-Moon Kyung and Eiji Tanaka :
Torque Ratio as a Predictable Factor on Primary Stability of Orthodontic Miniscrew Implants.,
Implant Dentistry, Vol.23, No.5, 576-581, 2014.

(要約): TR might be related with the miniscrew success rates, and it can be used as a predictable factor on primary stability of orthodontic miniscrew implants. Miniscrew implants should be replaced if MRT is significantly lower than MIT at placement surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/ID.0000000000000138
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25192157; ● Summary page in Scopus @ Elsevier: 2-s2.0-84927602268

(DOI: 10.1097/ID.0000000000000138, PubMed: 25192157, Elsevier: Scopus) 佐藤南, 石本恭子, 渡邉哲平, 黒田晋吾, 田中栄二 :
三次元形態計測装置を用いた顔面非対称の定量的評価,
中·四国矯正歯科学会雑誌, Vol.26, No.1, 25-32, 2014年. Yasunori Iwabuchi, Kotaro Tanimoto, Yuki Tanne, Toshihiro Inubushi, Takashi Kamiya, Ryo Kunimatsu, Naoto Hirose, Tomomi Mitsuyoshi, Shaoching Su, Eiji Tanaka and Kazuo Tanne :
Effects of low-intensity pulsed ultrasound on the expression of cyclooxygenase-2 in mandibular condylar chondrocytes.,
Journal of Oral & Facial Pain and Headache, Vol.28, No.3, 261-268, 2014.

(要約): LIPUS exposure inhibited IL-1-induced COX-2 expression through the integrin 1 receptor followed by the phosphorylation of ERK 1/2. Despite the restricted duration of its effect, LIPUS is suggested to be a potential candidate as a preventive and auxiliary treatment to suppress the degradation of articular chondrocytes in temporomandibular joint osteoarthritis.
(出版サイトへのリンク): ● Publication site (DOI): 10.11607/ofph.1156
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25068220; ● Summary page in Scopus @ Elsevier: 2-s2.0-84907004586

(DOI: 10.11607/ofph.1156, PubMed: 25068220, Elsevier: Scopus) Akihiro Yasue, Silvia Naomi Mitsui Akagi, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka :
Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems.,
Scientific Reports, Vol.4, 5705, 2014.

(要約): Since the establishment of embryonic stem (ES) cell lines, the combined use of gene targeting with homologous recombination has aided in elucidating the functions of various genes. However, the ES cell technique is inefficient and time-consuming. Recently, two new gene-targeting technologies have been developed: the transcription activator-like effector nuclease (TALEN) system, and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system. In addition to aiding researchers in solving conventional problems, these technologies can be used to induce site-specific mutations in various species for which ES cells have not been established. Here, by targeting the Fgf10 gene through RNA microinjection in one-cell mouse embryos with the TALEN and CRISPR/Cas systems, we produced the known limb-defect phenotypes of Fgf10-deficient embryos at the F0 generation. Compared to the TALEN system, the CRISPR/Cas system induced the limb-defect phenotypes with a strikingly higher efficiency. Our results demonstrate that although both gene-targeting technologies are useful, the CRISPR/Cas system more effectively elicits single-step biallelic mutations in mice.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/srep05705
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25027812; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904490723

(DOI: 10.1038/srep05705, PubMed: 25027812, Elsevier: Scopus) 井上雅秀, 黒田晋吾, 田中栄二 :
歯科矯正用アンカースクリュー埋入時の安定性に関する生体力学的研究,
四国歯学会雑誌, Vol.27, No.1, 27-34, 2014年.

(要約): Objective: The purpose of this study was to evaluate the influence of placement angle and force direction on the primary stability of orthodontic miniscrews by analyzing a novel threedimensional finite element model (FEM) approximating the interface between the screw and surrounding bone. Materials and Methods: Three-dimensional finite element models were made with 6-mm-long miniscrews in diameters of 1.2 mm. Four insertion angles ranging from 0̊ (perpendicular to the bone surface) to 45̊ were examined. A load with 2 N was applied to the center of the screw head in four directions (upward, downward and on the right and left sides). Results: For miniscrews at the same insertion angle, the stress was the highest (or lowest) under the downward (or upward) force condition. The stress increased as the insertion angle increased, except under the upward force condition. An analysis of the stress distribution in the surrounding bone showed that the most of the stress was absorbed in the cortical bone. Conclusions: The stress distribution around the miniscrew and surrounding bone during the application of orthodontic force is closely related to the force direction, and insertion angle.
(キーワード): アンカースクリュー / 有限要素解析 / 傾斜埋入
(徳島大学機関リポジトリ): ● Metadata: 109851
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807702400

(徳島大学機関リポジトリ: 109851, CiNii: 1050865122807702400) Masahiro Hiasa, Jumpei Teramachi, A Oda, Ryota Amachi, T Harada, Shingen Nakamura, Hirokazu Miki, Shiroh Fujii, Kumiko Kagawa, Keiichiro Watanabe, Itsuro Endo, Y Kuroda, T Yoneda, Daisuke Tsuji, Michiyasu Nakao, Eiji Tanaka, Kenichi Hamada, Shigeki Sano, Kouji Itou, Toshio Matsumoto and Masahiro Abe :
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.,
Leukemia, 2014.

(要約): Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel therapeutic target in MM. However, the impact of Pim-2 inhibition on bone disease in MM remains unknown. We demonstrated here that Pim-2 expression was also upregulated in bone marrow stromal cells and MC3T3-E1 preosteoblastic cells in the presence of cytokines known as the inhibitors of osteoblastogenesis in MM, including interleukin-3 (IL-3), IL-7, tumor necrosis factor-, transforming growth factor- (TGF-) and activin A, as well as MM cell conditioned media. The enforced expression of Pim-2 abrogated in vitro osteoblastogenesis by BMP-2, which suggested Pim-2 as a negative regulator for osteoblastogenesis. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restored osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiated BMP-2-mediated anabolic signaling while suppressing TGF- signaling. Furthermore, treatment with the newly synthesized thiazolidine-2,4-dione congener, 12a-OH, as well as its prototypic SMI-16a effectively prevented bone destruction while suppressing MM tumor growth in MM animal models. Thus, Pim-2 may have a pivotal role in tumor progression and bone loss in MM, and Pim-2 inhibition may become an important therapeutic strategy to target the MM cell-bone marrow interaction.Leukemia advance online publication, 30 May 2014; doi:10.1038/leu.2014.147.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/leu.2014.147
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24787487; ● Search Scopus @ Elsevier (PMID): 24787487; ● Search Scopus @ Elsevier (DOI): 10.1038/leu.2014.147

(DOI: 10.1038/leu.2014.147, PubMed: 24787487) Shingo Kuroda, Hiroto Watanabe, Akira Nakajima, Noriyoshi Shimizu and Eiji Tanaka :
Evaluation of torque moment in a novel elastic bendable orthodontic wire.,
Dental Materials Journal, Vol.33, No.3, 363-367, 2014.

(要約): The objective of the study was to measure the torque moment delivered by a novel elastic bendable wire, Ti-Nb wire, and to compare it with nickel-titanium (Ni-Ti) and titanium-molybdenum (Ti-Mo) alloy wires. Two sizes of Ti-Nb, Ni-Ti and Ti-Mo alloy wires and 0.022-inch slot stainless steel brackets were ligated with elastic modules or ligature wires. The torque moment delivered by the various wire-bracket combinations was measured using a torque gauge at the temperature and humidity of 37°C and 50%, respectively. As the degree of applied torque and the inserted wire size increased, the torque moment gradually increased. The torque moment of Ti-Nb wires was smaller than those of Ni-Ti wires and Ti-Mo wires, at more than 20 degrees applied torque. The torque moment with wire ligation was significantly larger than those with elastic ligation.
(キーワード): Torque moment / Orthodontic wire / Ti-Nb
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.2013-239
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24786348; ● CiNii @ 国立情報学研究所 (CRID): 1390001204716431360; ● Summary page in Scopus @ Elsevier: 2-s2.0-84901769199

(DOI: 10.4012/dmj.2013-239, PubMed: 24786348, CiNii: 1390001204716431360, Elsevier: Scopus) Natsuko Hichijo, Nobuhiko Kawai, Hiroyo Mori, R Sano, Y Ohnuki, S Okumura, J G E Langenbach and Eiji Tanaka :
Effects of the masticatory demand on the rat mandibular development.,
Journal of Oral Rehabilitation, Vol.41, No.8, 581-587, 2014.

(要約): The influence of masticatory loading stimulus on mandibular development is not fully clear. In this paper, experimental alterations in the daily muscle use, caused by a changed diet consistency, were continuously monitored, while adaptations in bone and cartilage were examined. It is hypothesised that decreased muscular loading will result in a decrease in the growth factor expression and mandible growth. Fourteen 21-day-old Wistar strain male rats were randomly divided into two groups and fed on either a hard or soft diet for 14 weeks. An implanted radio-telemetric device recorded continuously muscle activity of the superficial masseter muscle. Chondroblast proliferation in the condylar cartilage was identified by insulin-like growth factor-1 receptor (IGF-1r) immunostaining. Furthermore, an X-ray was taken for cephalometric analysis. In the soft-diet group, the duty time of the superficial masseter muscle at higher activity levels was significantly lower than that in the hard-diet group. This decrease in muscular loading of the jaw system was accompanied by: a significant reduction in (i) articular cartilage thickness, (ii) expression of IGF-1r immunopositive cells and (iii) mandible ramus height. In conclusion, a decrease in masticatory demand during the growth period leads to insufficient mandibular development.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.12171
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24702545; ● Search Scopus @ Elsevier (PMID): 24702545; ● Search Scopus @ Elsevier (DOI): 10.1111/joor.12171

(DOI: 10.1111/joor.12171, PubMed: 24702545) Shingo Kuroda, Mitsuhiro Iwata, Nagato Tamamura, KHALIUNAA GANZORIG, Natsuko Hichijo, Yuko Tomita and Eiji Tanaka :
Interdisciplinary treatment of a nonsyndromic oligodontia patient with implant-anchored orthodontics.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.145, No.4 Suppl, S136-47, 2014.

(要約): We successfully treated a nonsyndromic oligodontia patient with implant-anchored orthodontics and prosthetic restorations. A woman, age 18 years 11 months, had a straight profile and a skeletal Class I jaw-base relationship but had spaced arches because of 7 congenitally missing teeth. After leveling and alignment of the dentition, a titanium miniscrew was temporarily placed at the distal alveolus of the mandibular right first premolar, and the posterior teeth were mesialized to reduce the restorative spaces. After determination of the incisor positions, 3 dental implants were respectively inserted at the sites of the maxillary canines and the mandibular left lateral incisor with guided bone regeneration procedures. Then, screw-retained temporary prostheses were delivered after subepithelial connective tissue grafting and used for molar mesialization as absolute anchorage. After 36 months of active orthodontic treatment, an acceptable occlusion was achieved, both functionally and esthetically, with the 3 dental implants. The maxillary and mandibular molars were mesialized, but the changes of incisor position were minimal. As a result, a proper facial profile was maintained, and an attractive smile was achieved. The resultant occlusion was stable throughout a 3-year retention period. In conclusion, interdisciplinary treatment combined with orthodontics, implant surgery, and prosthodontics was useful for a nonsyndromic oligodontia patient. Especially, the new strategy-implant-anchored orthodontics-can facilitate the treatment more simply with greater predictability.
(キーワード): Anodontia / Bone Regeneration / Bone Screws / Cephalometry / Dental Implants / Female / Humans / Orthodontic Anchorage Procedures / Orthodontics, Corrective / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2013.06.023
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24680022; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897392643

(DOI: 10.1016/j.ajodo.2013.06.023, PubMed: 24680022, Elsevier: Scopus) Teppei Watanabe, Akihiro Yasue and Eiji Tanaka :
Hypoxia-inducible factor-1 is required for transforming growth factor-1-induced type I collagen, periostin and -smooth muscle actin expression in human periodontal ligament cells.,
Archives of Oral Biology, Vol.59, No.6, 595-600, 2014.

(要約): HIF-1 is required for TGF-1-induced type I collagen, periostin and -SMA expression in human PDL cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2014.03.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24690594; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897395051

(DOI: 10.1016/j.archoralbio.2014.03.003, PubMed: 24690594, Elsevier: Scopus) Eiji Tanaka, Fernández Pelayo, Namhee Kim, Jesús María Lamela, Nobuhiko Kawai and Alfonso Fernández-Canteli :
Stress relaxation behaviors of articular cartilages in porcine temporomandibular joint.,
Journal of Biomechanics, Vol.47, No.7, 1582-1587, 2014.

(要約): In this study, we tested the compressive stress relaxation behaviors of the mandibular condylar and temporal cartilages in the porcine temporomandibular joint (TMJ). The aim was to determine the quantitative and qualitative similarities and differences of compressive stress relaxation behaviors between the two cartilages. Ten porcine TMJs were used; the articular surface was divided into 5 regions: anterior, central, posterior, lateral and medial. Compressive relaxation test was carried out at a strain level of 5% in each region of the two cartilages. The stress relaxation was monitored over a period of 5min. In all the regions of the two cartilages, the time-dependent stress relaxation curves showed a marked drop in stress within the initial 10s, which can be fitted by a standard linear viscoelastic model. The instantaneous moduli in the temporal cartilage were dominantly larger than those in the condylar cartilage, while the condylar cartilage had slightly larger relaxation moduli than the temporal cartilage except for the medial region. The both cartilages showed the regional differences in the compressive stress relaxation behavior, and in the temporal cartilage the lateral and medial regions revealed the largest values for the instantaneous and relaxation moduli. The present results demonstrate that the viscoelastic properties of compressive stress relaxation in both cartilages are region-specific, which might have an important implication for stress distribution and transmission along with the TMJ disc.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jbiomech.2014.03.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24680920; ● Search Scopus @ Elsevier (PMID): 24680920; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jbiomech.2014.03.007

(DOI: 10.1016/j.jbiomech.2014.03.007, PubMed: 24680920) S Maria Commisso, Javier Martínez-Reina, Juana Mayo, Jaime Domínguez and Eiji Tanaka :
Effect of non-uniform thickness of samples in stress relaxation tests under unconfined compression of samples of articular discs.,
Journal of Biomechanics, Vol.47, No.6, 1526-1530, 2014.

(要約): A precise information of the biomechanical properties of soft tissues is required to develop a suitable simulation model, with which the distribution of stress and strain in the complex structures can be estimated. Many soft tissues have been mechanically characterized by stress relaxation tests under unconfined or confined compression. In general, full-thickness samples are extracted to reduce the damage in the tissue as much as possible. However, it is not guaranteed that these samples have a uniform thickness or, in other words, planar parallel faces. In particular, in the articular disc of the temporomandibular joint, many studies can be found testing full-thickness samples for which that thickness is known to be non-uniform, while making the assumption of uniaxial stress state to extract the mechanical properties from those tests. That inaccuracy may have a strong influence in some cases and needs a profound revision. The main goal of this work is to quantify the error committed in that assumption and the influence of the variation of thickness on that error in a particular test: stress relaxation tests under unconfined compression. Based on this error and defining an allowable tolerance, a criterion is established to reject samples depending on their aspect ratio.
(キーワード): Algorithms / Animals / Biomechanical Phenomena / Computer Simulation / Finite Element Analysis / Models, Biological / Pressure / Stress, Mechanical / Swine / Temporomandibular Joint
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jbiomech.2014.02.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24581817; ● Search Scopus @ Elsevier (PMID): 24581817; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jbiomech.2014.02.008

(DOI: 10.1016/j.jbiomech.2014.02.008, PubMed: 24581817) 藤原慎視, 中村竜也, 永田久美子, 桂智子, 塩田智子, 堀内信也, 黒田晋吾, 清家卓也, 橋本一郎, 中西秀樹, 永井宏和, 宮本洋二, 田中栄二 :
顎顔面領域における骨治癒に対する低出力超音波パルス照射の使用経験,
四国歯学会雑誌, Vol.26, No.2, 41-47, 2014年.

(徳島大学機関リポジトリ): ● Metadata: 109843

(徳島大学機関リポジトリ: 109843) Toshihiro Inubushi, A Kawazoe, Mutsumi Miyauchi, S Yanagisawa, A Subarnbhesaj, C Chanbora, F N Ayuningtyas, A Ishikado, Eiji Tanaka and Takashi Takata :
Lactoferrin inhibits infection-related osteoclastogenesis without interrupting compressive force-related osteoclastogenesis.,
Archives of Oral Biology, Vol.59, No.2, 226-232, 2014.

(要約): bLF can effectively suppress harmful bone destruction associated with periodontitis without inhibiting bone remodelling by CS-loading. Therefore, oral administration of bLF may be highly beneficial for control of periodontitis in orthodontic patients.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2013.11.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24370195; ● Summary page in Scopus @ Elsevier: 2-s2.0-84890520986

(DOI: 10.1016/j.archoralbio.2013.11.002, PubMed: 24370195, Elsevier: Scopus) Santos Araujo Rui Mauricio de, Yasuo Oba, Shingo Kuroda, Eiji Tanaka and Keiji Moriyama :
RhoE regulates actin cytoskeleton organization in human periodontal ligament cells under mechanical stress.,
Archives of Oral Biology, Vol.59, No.2, 187-192, 2014.

(要約): These results indicate that the loss and disassembly of stress fibres due to mechanical stress are mediating RhoE signalling, without the exertion of RGS2.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2013.11.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24370190; ● Summary page in Scopus @ Elsevier: 2-s2.0-84890259559

(DOI: 10.1016/j.archoralbio.2013.11.010, PubMed: 24370190, Elsevier: Scopus) Shinya Horiuchi, Masahiro Hiasa, Akihiro Yasue, Kazumitsu Sekine, Kenichi Hamada, Kenzo Asaoka and Eiji Tanaka :
Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.29C, 151-160, 2014.

(要約): Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate (ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. Compositional analysis by powder X-ray diffraction analysis revealed that HAP crystals were precipitated in the CPC containing 10 or 30wt% ZCP after successfully hardening. However, the crystal growth observed by scanning electron microscopy was delayed in the presence of additional ZCP. These findings indicate that the additional zinc inhibits crystal growth and the conversion of CPC to the HAP crystals. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potent promotional effect on bone substitute biomaterials.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2013.09.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24090874; ● Summary page in Scopus @ Elsevier: 2-s2.0-84884959362

(DOI: 10.1016/j.jmbbm.2013.09.005, PubMed: 24090874, Elsevier: Scopus) Silvia Naomi Mitsui Akagi, Akihiro Yasue, Kiyoshi Masuda, Keiichiro Watanabe, Shinya Horiuchi, Issei Imoto and Eiji Tanaka :
Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis.,
Journal of Dental Research, Vol.93, No.3, 245-249, 2014.

(要約): PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutations in the paired domain of PAX9, a three-nucleotide deletion (73-75 delATC) and a missense mutation (C146T), in two unrelated Japanese patients with non-syndromic tooth agenesis. The individual with the 73-75del ATC mutation was missing all maxillary molars and mandibular second and third molars. The individual with the C146T mutation was missing the mandibular central incisors, maxillary second premolars, and first molars, along with all second and third molars. Both mutations affected amino acids that are highly conserved among different species and are critical for DNA binding. When both mutants were transfected to COS7 cells, nuclear localization of PAX9 proteins was not affected. However, reduced expression of the mutant proteins and almost no transcriptional activity of the target BMP4 gene were observed, suggesting haploinsufficiency of PAX9 as the cause of non-syndromic tooth agenesis.
(徳島大学機関リポジトリ): ● Metadata: 109722
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0022034513519801
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24436340; ● Summary page in Scopus @ Elsevier: 2-s2.0-84894493206

(徳島大学機関リポジトリ: 109722, DOI: 10.1177/0022034513519801, PubMed: 24436340, Elsevier: Scopus) Jesús María Lamela, Fernández Pelayo, Alberto Ramos, Alfonso Fernández-Canteli and Eiji Tanaka :
Analysis of compressive properties of porcine temporomandibular joint disc.,
Key Engineering Materials, Vol.592-593, 354-357, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.4028/www.scientific.net/KEM.592-593.354
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84891879244

(DOI: 10.4028/www.scientific.net/KEM.592-593.354, Elsevier: Scopus) A Kawazoe, Toshihiro Inubushi, Mutsumi Miyauchi, A Ishikado, Eiji Tanaka, Kazuo Tanne and Takashi Takata :
Orally administered liposomal lactoferrin inhibits inflammation-related bone breakdown without interrupting orthodontic tooth movement.,
Journal of Periodontology, Vol.84, No.10, 1454-1462, 2013.

(要約): Background: Bovine lactoferrin (bLF) modulates the production of tumor necrosis factor-alpha (TNF-) and inhibits alveolar bone breakdown associated with periodontitis. This study is designed to examine the effects of orally administered liposomal bLF (LbLF) on orthodontic force (OF)-induced alveolar bone remodeling during experimental tooth movement. Methods: Two groups of male Wistar rats were treated with either LbLF or control solution in drinking water 7 days before OF application. Lipopolysaccharide (LPS) was injected into the gingival sulcus in half the rats in each group. Thus, four groups: OF, OF+LbLF, OF+LPS, and OF+LPS+LbLF were established. Results: Orally administered LbLF significantly reduced apical migration of junctional epithelium in the OF and OF+LPS groups. In OF+LPS, osteoclast number in the alveolar crestal area was increased by LPS treatment, whereas osteoclast number was significantly reduced in OF+LPS+LbLF through suppression of TNF- production. Osteoclastic induction in the middle part, mainly from OF application, was not affected by LbLF administration. Inhibition of tooth movement was not induced by LbLF. Conclusions: Orally administered LbLF significantly inhibits LPS-induced alveolar bone resorption but not OF-induced bone remodeling. LbLF could be a potent therapeutic and preventive agent to control periodontal inflammation in patients undergoing orthodontic treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1902/jop.2012.120508
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23136974; ● Search Scopus @ Elsevier (PMID): 23136974; ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2012.120508

(DOI: 10.1902/jop.2012.120508, PubMed: 23136974) Teppei Watanabe, Akihiro Yasue and Eiji Tanaka :
Inhibition of Transforming Growth Factor 1 (TGF-1)/ Smad3 Signaling Decreases Hypoxia-Inducible Factor 1 (HIF-1) Protein Stability by Inducing Prolyl Hydroxylase 2 (PHD2) Expression in Human Periodontal Ligament Cells.,
Journal of Periodontology, Vol.84, No.9, 1346-1352, 2013.

(要約): Background: Hypoxia-inducible factor 1 (HIF-1), the alpha subunit of the heterodimeric transcription factor HIF-1, maintains oxygen homeostasis by regulating gene expression. Under normoxic conditions, HIF-1 expression is maintained at low steady-state levels by the critical oxygen sensor prolyl hydroxylase 2 (PHD2). Transforming growth factor 1 (TGF-1) activates Smad3 signaling and contributes to HIF-1 stabilization under normoxic conditions. In chronic periodontitis, HIF-1 is expressed highly in gingival fibroblasts and upregulates inflammatory factor transcription, which promotes periodontal inflammation. Here, we investigated the effect of TGF-1/Smad3 signaling and its blockade by the specific inhibitor of Smad3 (SIS3) on HIF-1 expression and stability in human periodontal ligament (PDL) cells. Methods: We investigated the effect of TGF-1 on HIF-1 protein stability using cycloheximide (CHX). Furthermore, we analyzed HIF-1 expression, PHD2 expression and Smad3 phosphorylation following TGF-1 stimulation in the presence or absence of SIS3. Results: The half-life of HIF-1 was prolonged in TGF-1-treated cells. TGF-1 treatment induced HIF-1 gene expression and enhanced HIF-1 protein stability while decreasing PHD2 expression and activating Smad3 phosphorylation. Notably, HIF-1 protein expression was not detectable prior to TGF-1 stimulation. Furthermore, SIS3 treatment abrogated Smad3 phosphorylation, impaired TGF-1-induced HIF-1 gene expression and protein stability and stimulated TGF-1-mediated PHD2 inhibition. Conclusions: These results demonstrate that HIF-1 transcription and protein synthesis are controlled by TGF-1/Smad3 signaling, whereas HIF-1 protein stability is controlled by PHD2, which is regulated by TGF-1/Smad3 signaling.
(出版サイトへのリンク): ● Publication site (DOI): 10.1902/jop.2012.120373
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23088526; ● Search Scopus @ Elsevier (PMID): 23088526; ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2012.120373

(DOI: 10.1902/jop.2012.120373, PubMed: 23088526) Yuko Tomita, Shingo Kuroda, Takumi Takahashi, Ritsuko Ohura and Eiji Tanaka :
Orthodontic occlusal reconstruction after conservative treatment of unicystic ameloblastoma in an adolescent patient: 10-year follow-up.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.144, No.3, 466-470, 2013.

(要約): Conservative treatment of an ameloblastoma often requires an occlusal reconstruction. In this article, we report the successful interdisciplinary treatment of a 14-year-old girl with a unicystic ameloblastoma in the mandible. One year after the marsupialization, enucleation with bone curettage was performed with extraction of the impacted third molar, but the proximal second molar could be maintained. The conservative treatment required long-term use of an obturator, and it caused a total open bite. Additionally, the patient genetically had a Class II malocclusion with severe crowding. Consequently, orthodontic treatment was performed after 4 premolar extractions. There was no recurrence of the ameloblastoma 10 years after the enucleation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2012.06.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23992819; ● Search Scopus @ Elsevier (PMID): 23992819; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2012.06.021

(DOI: 10.1016/j.ajodo.2012.06.021, PubMed: 23992819) Yoshiki Ohnuki, Daisuke Umeki, Wenqian Cai, Nobuhiko Kawai, Yasumasa Mototani, Kouichi Shiozawa, Hui-Ling Jin, Takayuki Fujita, Eiji Tanaka, Yasutake Saeki and Satoshi Okumura :
Role of Masseter Muscle 2-Adrenergic Signaling in Regulation of Muscle Activity, Myosin Heavy Chain Transition, and Hypertrophy.,
Journal of Pharmacological Sciences, Vol.123, No.1, 36-46, 2013.

(要約): Chronic administration of clenbuterol (CB), a lipophilic 2-adrenoceptor (2-AR) agonist, induces skeletal muscle hypertrophy and slow-to-fast fiber-type transitions in mammalian species, but the mechanism and pathophysiological roles of these changes have not been explored. Here, we examined the effects of CB not only on masseter muscle mass, fiber diameter, and myosin heavy chain (MHC) composition, but also on daily muscle activity, a factor influencing muscle phenotype, by means of electromyogram analysis in rats. MHC transition towards faster isoforms was induced by 2-week CB treatment. In addition, daily duty time was increased at 1 day, 1 week, and 2 weeks after the start of CB treatment and its increase was greater at high activity level (6-fold) than at low activity level (2-fold). In order to examine whether these effects of CB were mediated through muscle or CNS 2-AR stimulation, we compared these effects of CB with those of salbutamol (SB), a hydrophilic 2-AR agonist. SB treatment induced masseter hypertrophy and MHC transition, like CB, but did not increase daily activity. These results suggest that CB-mediated slow-to-fast MHC transition with hypertrophy was induced through direct muscle 2-AR stimulation, but the increase of daily duty time was mediated through the CNS.[Supplementary Figures: available only at http://dx.doi.org/10.1254/jphs.12271FP].
(出版サイトへのリンク): ● Publication site (DOI): 10.1254/jphs.12271FP
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23985574; ● Search Scopus @ Elsevier (PMID): 23985574; ● Search Scopus @ Elsevier (DOI): 10.1254/jphs.12271FP

(DOI: 10.1254/jphs.12271FP, PubMed: 23985574) 前田有一, 泰江章博, 大浦徳永律子律子, ミツイアカギシルビアナオミ, 中村竜也, 渡邉佳一郎, 高橋巧, 田中栄二 :
Hypodontiaを伴う二卵性双生児の下顎後退症例,
中·四国矯正歯科学会雑誌, Vol.25, No.1, 43-50, 2013年. 金南希, 堀内信也, 天知良太, 川合暢彦, 木内奈央, 藤原慎視, 黒田晋吾, 田中栄二 :
三次元デジタルモデルを用いた片側性口唇口蓋裂患者の咬合評価に関する検討第二報デジタルツールが三次元デジタル模型の評価に及ぼす影響,
中·四国矯正歯科学会雑誌, Vol.25, No.1, 21-28, 2013年. 長岡敬子, 田中栄二 :
上下顎同時移動術により下顔面高の過大を改善した骨格性下顎前突症例,
四国歯学会雑誌, Vol.26, No.1, 17-22, 2013年.

(徳島大学機関リポジトリ): ● Metadata: 109839

(徳島大学機関リポジトリ: 109839) Emi Kawakami, Nobuhiko Kawai, Nao Kinouchi, Hiroyo Mori, Yutaka Ohsawa, Naozumi Ishimaru, Yoshihide Sunada, Sumihare Noji and Eiji Tanaka :
Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function.,
PLoS ONE, Vol.8, No.5, 2013.

(要約): These data suggest local administration of Mst-siRNA/ATCOL complex could lead to skeletal muscle hypertrophy and recovery of motor disability in mCAV-3Tg mice. Therefore, ATCOL-mediated application of siRNA is a potential tool for therapeutic use in muscular atrophy diseases.
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0064719
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23717655; ● Search Scopus @ Elsevier (PMID): 23717655; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0064719

(DOI: 10.1371/journal.pone.0064719, PubMed: 23717655) Naoko Yoneda, Akihiro Yasue, Teppei Watanabe and Eiji Tanaka :
Down-regulation of Smad3 Accelerates Palatal Wound Repair.,
Journal of Dental Research, Vol.92, No.8, 716-720, 2013.

(要約): Smad3-deficient mice exhibit accelerated re-epithelialization and tissue remodeling during palatal wound repair. In addition, transforming growth factor beta 1 (TGF-1) and other inflammatory factors are down-regulated compared with those in wild-type mice. The aim of this study was to examine whether targeting of Smad3 with small interfering RNA (siRNA) accelerates wound-healing and inhibits wound contraction in palatal mucoperiosteal wounds. An initial histological examination of wound closure in mouse palates treated with Smad3-targeted siRNA vs. a scrambled siRNA found that wound-healing was accelerated when levels of Smad3 were decreased. Furthermore, with real-time PCR, mRNA levels of Smad3, TGF-1, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1 (MIP-1) were found to be significantly down-regulated in palatal tissue treated with Smad3-targeted siRNA vs. a control siRNA. Protein and mRNA levels of -smooth-muscle actin (-SMA), type I collagen, and fibronectin were also lower in palates treated with Smad3-targeted siRNA vs. control siRNA. Taken together, these results indicate that down-regulation of Smad3 expression by siRNA can accelerate wound-healing and may inhibit wound contraction. Therefore, siRNA-targeted inhibition of Smad3 may represent a valuable therapeutic tool for palatal mucoperiosteal wound-healing.
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0022034513491575
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23694929; ● Search Scopus @ Elsevier (PMID): 23694929; ● Search Scopus @ Elsevier (DOI): 10.1177/0022034513491575

(DOI: 10.1177/0022034513491575, PubMed: 23694929) Jesús María Lamela, Fernández Pelayo, Alberto Ramos, Alfonso Fernández-Canteli and Eiji Tanaka :
Dynamic compressive properties of articular cartilages in the porcine temporomandibular joint.,
Journal of the Mechanical Behavior of Biomedical Materials, Vol.23C, 62-70, 2013.

(要約): The mandibular condylar and temporal cartilages in the temporomandibular joint (TMJ) play an important role as a stress absorber during function. However, relatively little information is available on its viscoelastic properties in dynamic compression, particularly in a physiological range of frequencies. We hypothesized that these properties are region-specific and depend on loading frequency. To characterize the viscoelastic properties of both cartilages, we performed dynamic indentation tests over a wide range of loading frequencies. Nine porcine TMJs were used; the articular surface was divided into five regions: anterior; central; posterior; medial and lateral. Sinusoidal compressive strain was applied with an amplitude of 1.0% and a frequency range between 0.01 and 10Hz. In both cartilages, the dynamic storage modulus increased with frequency, and the value was the highest in the lateral region. These values of E' in the temporal cartilage were smaller than those in the mandibular condylar cartilage in all five regions except the lateral region. The Loss tangent values were higher in the temporal cartilage (0.35-0.65) than in the mandibular condylar one (0.2-0.45), which means that the temporal cartilage presents higher viscosity. The present results suggest that the dynamic compressive moduli in both cartilages are region-specific and dependent on the loading frequency, which might have important implications for the transmission of load in the TMJ.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jmbbm.2013.04.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23660305; ● Search Scopus @ Elsevier (PMID): 23660305; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2013.04.006

(DOI: 10.1016/j.jmbbm.2013.04.006, PubMed: 23660305) Kotaro Tanimoto, Y Tanne, K Sumi, N Hirose, Nobuhiko Kawai, Eiji Tanaka and Kazuo Tanne :
Longitudinal changes in the height and location of bone bridge from autogenous iliac bone graft in patients with cleft lip and palate.,
Open Journal of Stomatology, Vol.3, No.1, 58-62, 2013.

(出版サイトへのリンク): ● Publication site (DOI): 10.4236/ojst.2013.31011
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4236/ojst.2013.31011

(DOI: 10.4236/ojst.2013.31011) Susumu Abe, Fumiaki Kawano, K Kohge, T Kawaoka, K Ueda, E Hattori-Hara, H Mori, Shingo Kuroda and Eiji Tanaka :
Stress analysis in human temporomandibular joint affected by anterior disc displacement during prolonged clenching.,
Journal of Oral Rehabilitation, Vol.40, No.4, 239-246, 2013.

(要約): Parafunctional habits, such as prolonged clenching and bruxism, have been associated with dysfunctional overloading in the temporomandibular joint (TMJ). In this study, stress distributions in the TMJ were analysed during prolonged clenching, using three-dimensional finite element (FE) models of the TMJ with and without disc displacement. The aim of this study was to investigate stress distribution of the cartilaginous tissues in the TMJ with and without disc displacement. Finite element models were developed on the basis of magnetic resonance images from two subjects with and without anterior disc displacement. Condylar movements recorded during a 5-min clenching were used as the loading condition for stress analysis. In the asymptomatic model, the highest von Mises stresses were located in the lateral area (4·91 MPa) of the disc surfaces, and after 5-min clenching, the higher stresses were still located at the lateral area (3·65 MPa). In all the cartilaginous tissues, 30-50% of stress reduction occurred during 5-min clenching. In contrast, the von Mises stress in the cartilaginous tissues of the symptomatic model with disc displacement was markedly lower, compared with the asymptomatic model. However, in the condylar cartilage, stress relaxation during clenching was not recognised. Furthermore, relatively high stresses were observed in the retrodiscal tissues throughout clenching. The present results indicate that disc position could be involved in the stress distribution of the TMJ components during prolonged clenching.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/joor.12036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23398635; ● Search Scopus @ Elsevier (PMID): 23398635; ● Search Scopus @ Elsevier (DOI): 10.1111/joor.12036

(DOI: 10.1111/joor.12036, PubMed: 23398635) Kumiko Nagata, Tatsuya Nakamura, Shinji Fujihara and Eiji Tanaka :
Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles.,
Annals of Biomedical Engineering, Vol.41, No.6, 1095-1105, 2013.

(要約): The purpose of this study was to examine the effect of ultrasound on inflammatory skeletal muscle in vitro and in vivo. C2C12 cells were cultured in medium with or without TNF-α or IL-1β. After stimulation with cytokines, the cells received ultrasound or sham exposure. Furthermore, the tibialis anterior (TA) muscle in C57BL/6 mice injured by cardiotoxin (CTX) were dissected after a series of ultrasound treatments and examined. Exposure of C2C12 cells to ultrasound resulted in down-regulation of cyclooxygenase-2 (COX-2) mRNA and protein expression induced by TNF-α or IL-1β, and up-regulated myogenin mRNA and protein depressed by TNF-α or IL-1β. In injured TA muscle induced by CTX, ultrasound caused increase of COX-2 mRNA at 1 day after ultrasound treatment, however, at day 5, reduction of COX-2 mRNA and protein. At day 5, ultrasound caused increase of myogenin mRNA and protein, increase of fast myosin protein, and increase of paired-box transcription factor 7 positive cells. At day 7, the cross-sectional area of myofibers in the ultrasound exposure side was significantly larger than that on the control side. In conclusion, ultrasound stimulation may be a better candidate as a medical remedy to promote myogenesis in inflammatory muscle states, such as muscle injury.
(キーワード): Acoustics / Animals / Cell Line / Cobra Venoms / Cyclooxygenase 2 / Gene Expression Regulation / Interleukin-1beta / Mice / Mice, Inbred C57BL / Muscle, Skeletal / Myogenin / Myositis / PAX7 Transcription Factor / RNA, Messenger / Regeneration / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-013-0757-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23386031; ● Search Scopus @ Elsevier (PMID): 23386031; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-013-0757-y

(DOI: 10.1007/s10439-013-0757-y, PubMed: 23386031) Toshihiro Inubushi, Eiji Tanaka, B Emanuel Rego, Junji Ohtani, Aki Kawazoe, Kazuo Tanne, Mutsumi Miyauchi and Takashi Takata :
Ultrasound stimulation attenuates resorption of tooth root induced by experimental force application.,
Bone, Vol.53, No.2, 497-506, 2013.

(要約): Root resorption is an adverse outcome of orthodontic tooth movement. However, there have been no available approaches for the protection and repair of root resorption. The aim of this study was to evaluate the effects of low-intensity pulsed ultrasound (LIPUS) on root resorption during experimental tooth movement and the effects of LIPUS in the RANKL/OPG mechanism in osteoblasts and cementoblasts in vitro. Twenty four Wistar strain male rats of 12-week-old were used in this study. The upper first molars were subjected to experimental movement in the mesial direction for 1-3weeks. Through the experimental periods, the right upper first maxillary molar was exposed to LIPUS (LIPUS group) every day for 1, 2 or 3weeks. The nature of root resorption was observed and then quantified by histomorphometric analysis. In the 2weeks period, significantly greater amount of tooth movement was observed in the LIPUS group (p<0.05). In addition, LIPUS group showed less root resorption lacunae and lower number of odontoclasts. In the period of 3weeks, LIPUS group presented significantly shorter length of root resorption lacunae and smaller amount of root resorption area (p<0.01). The number of odontoclasts and osteoclasts was also significantly lower in the LIPUS group (p<0.01 and p<0.05, respectively). However, no significant differences could be found regarding the amount of tooth movement. It is shown that LIPUS exposure significantly reduced the degree of root resorption during tooth movement without interrupting tooth movement. In vitro experiments showed that MC3T3-1 constitutively expressed higher levels of RANKL and RANTES mRNA comparing to OCCM-30. However, OPG mRNA expression was much higher in OCCM-30. LIPUS stimulation significantly increased the mRNA expression of RANKL in MC3T3-E1 at 4 (p<0.01) and 12h (p<0.05), although OPG mRNA expression was not affected by LIPUS. In contrast, the expression of RANKL and OPG mRNAs were both significantly increased by LIPUS in OCCM-30 at 12h (p<0.01). Moreover, LIPUS application suppressed the up-regulation of RANKL mRNA induced by compression force in OCCM-30, but no similar effect could be observed in MC3T3-E1. In conclusion, it is suggested that LIPUS exposure significantly reduces root resorption by the suppression of cementoclastogenesis by altering OPG/RANKL ratio during orthodontic tooth movement without interfering tooth movement. LIPUS may be an effective tool to prevent root resorption during tooth movement and is applicable to clinical use in near future.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bone.2013.01.021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23337039; ● Search Scopus @ Elsevier (PMID): 23337039; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bone.2013.01.021

(DOI: 10.1016/j.bone.2013.01.021, PubMed: 23337039) Ritsuko 徳永律子 Oura, Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
Induction of Rapid T Cell Death and Phagocytic Activity by Fas-Deficient lpr Macrophages.,
The Journal of Immunology, 2013.

(要約): Peripheral T cells are maintained by the apoptosis of activated T cells through the Fas-Fas ligand system. Although it is well known that normal T cells fail to survive in the Fas-deficient immune condition, the molecular mechanism for the phenomenon has yet to be elucidated. In this study, we demonstrate that rapid cell death and clearance of normal T cells were induced by Fas-deficient lpr macrophages. Transfer of normal T cells into lpr mice revealed that Fas expression on donor T cells was promptly enhanced through the IFN-/IFN-R. In addition, Fas ligand expression and phagocytic activity of lpr macrophages were promoted through increased NF-B activation. Controlling Fas expression on macrophages plays an essential role in maintaining T cell homeostasis in the peripheral immune system. Our data suggest a critical implication to the therapeutic strategies such as transplantation and immunotherapy for immune disorder or autoimmunity related to abnormal Fas expression.
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/jimmunol.1103794
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23255359; ● Search Scopus @ Elsevier (PMID): 23255359; ● Search Scopus @ Elsevier (DOI): 10.4049/jimmunol.1103794

(DOI: 10.4049/jimmunol.1103794, PubMed: 23255359) Hirai Miyuki, Nakajima Akira, Nobuhiko Kawai, Eiji Tanaka, Igarashi Yu, Sakaguchi Masahito, Sameshima T. Glenn and Shimizu Noriyoshi :
Measurements of the torque moment in various archwire-bracket-ligation combinations,
European Journal of Orthodontics, Vol.34, No.3, 374-380, 2012.

(要約): The torque moment generated by third-order bends is important for tooth movement. The purpose of this study was to measure the torque moment that can be delivered by various archwire and bracket combinations at the targeted tooth. Stainless steel (SS) upper brackets with 0.018 and 0.022 inch slots, two sizes of nickel-titanium (Ni-Ti) alloy wires, and three sizes of SS wires for each bracket were used. The wire was ligated with elastics or wire. The torque moment delivered by the various archwire-bracket-ligation combinations was measured using a torque gauge. Statistical analysis was undertaken using analysis of variance (multiple comparison tests and post hoc using Tukey's honestly significant difference test. The torque moment increased as the degree of torque and wire size increased. There was no significant difference in torque moment between the SS and Ni-Ti wires at lower or higher than 40 degrees torque. The torque moment with wire ligation was significantly larger than that with elastic ligation with 0.016 × 0.022 and 0.017 × 0.025 inch Ni-Ti wires in the 0.018 inch slot brackets and the 0.017 × 0.025 and 0.019 × 0.025 inch SS and Ni-Ti wires in the 0.022 inch slot brackets. However, there was no significant difference in torque moment between either ligation method when using the full slot size wires.
(キーワード): Analysis of Variance / Dental Alloys / Dental Stress Analysis / Elastomers / Materials Testing / Nickel / Orthodontic Appliance Design / Orthodontic Brackets / Orthodontic Wires / Stainless Steel / Statistics, Nonparametric / Titanium / Torque
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejo/cjr022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21571875; ● Search Scopus @ Elsevier (PMID): 21571875; ● Search Scopus @ Elsevier (DOI): 10.1093/ejo/cjr022

(DOI: 10.1093/ejo/cjr022, PubMed: 21571875) Braga Emanuel Rego, Takashi Takata, Kazuo Tanne and Eiji Tanaka :
Current status of low intensity pulsed ultrasound for dental purposes.,
The Open Dentistry Journal, Vol.6, 220-225, 2012.

(要約): Over the past few years, tissue engineering applied to the dental field has achieved relevant results. Tissue engineering can be described by actions taken to improve biological functions. Several methods have been described to enhance cellular performance and low intensity pulsed ultrasound (LIPUS) has shown to play an important role in cell metabolism. The present article provides an overview about the current status of LIPUS as a tissue engineering tool to be used to enhance tooth and periodontal regeneration.
(出版サイトへのリンク): ● Publication site (DOI): 10.2174/1874210601206010220
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23341848; ● Search Scopus @ Elsevier (PMID): 23341848; ● Search Scopus @ Elsevier (DOI): 10.2174/1874210601206010220

(DOI: 10.2174/1874210601206010220, PubMed: 23341848) Pelayo Fernández, María Lamela Jesús, Alberto Ramos, Alfonso Fernández-Canteli and Eiji Tanaka :
The region-dependent dynamic properties of porcine temporomandibular joint disc under unconfined compression.,
Journal of Biomechanics, Vol.46, No.4, 845-848, 2012.

(要約): In this study, the dynamic compressive properties in five different regions of the porcine temporomandibular joint (TMJ) disc are investigated over a wide range of loading frequencies. The aim was, thus far, to evaluate the regional difference and the frequency-related effect of the applied load on these properties. Eleven porcine TMJ discs were used; each disc was divided into 5 regions, anterior, central, posterior, lateral and medial. Sinusoidal compressive strain was applied with an amplitude of 1.0% and a frequency range between 0.01 and 10Hz. The dynamic storage and loss moduli increase with frequency, the highest values being attained at the posterior region, followed by the central and anterior regions. Loss tangent, tan, ranged from 0.20 to 0.35, which means that the disc is primarily elastic in nature and has a small but not negligible viscosity. The present results suggest that the dynamic viscoelastic compressive modulus is region-specific and depends on the loading frequency, thus having important implications for the transmission of load to the TMJ.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jbiomech.2012.11.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23261240; ● Search Scopus @ Elsevier (PMID): 23261240; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jbiomech.2012.11.035

(DOI: 10.1016/j.jbiomech.2012.11.035, PubMed: 23261240) Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko 徳永律子 Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice,
PLoS ONE, Vol.7, No.12, e48798, 2012.

(要約): BACKGROUND: Although autoimmunity in MRL/lpr mice occurs due to a defect in Fas-mediated cell death of T cells, the role of Fas-independent apoptosis in pathogenesis has rarely been investigated. We have recently reported that receptor activator of nuclear factor (NF)-B ligand (RANKL)-activated dendritic cells (DCs) play a key role in the pathogenesis of rheumatoid arthritis (RA) in MRL/lpr mice. We here attempted to establish a new therapeutic strategy with RANKL-activated DCs in RA by controlling apoptosis of peripheral T cells. Repeated transfer of RANKL-activated DCs into MRL/lpr mice was tested to determine whether this had a therapeutic effect on autoimmunity. METHODS AND FINDING: Cellular and molecular mechanisms of Fas-independent apoptosis of T cells induced by the DCs were investigated by in vitro and in vivo analyses. We demonstrated that repeated transfers of RANKL-activated DCs into MRL/lpr mice resulted in therapeutic effects on RA lesions and lymphoproliferation due to declines of CD4(+) T, B, and CD4(-)CD8(-) double negative (DN) T cells. We also found that the Fas-independent T-cell apoptosis was induced by a direct interaction between tumor necrosis factor (TNF)-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) on T cells and TRAIL on Fas-deficient DCs in MRL/lpr mice. CONCLUSION: These results strongly suggest that a novel Fas-independent apoptosis pathway in T cells maintains peripheral tolerance and thus controls autoimmunity in MRL/lpr mice.
(徳島大学機関リポジトリ): ● Metadata: 110974
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0048798
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23300516; ● Search Scopus @ Elsevier (PMID): 23300516; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0048798

(徳島大学機関リポジトリ: 110974, DOI: 10.1371/journal.pone.0048798, PubMed: 23300516) Eiji Tanaka, Shinya Horiuchi and Shingo Kuroda :
Orthognathic and orthodontic treatments for TMJ-osteoarthritis with jaw deformity,
The Japanese Journal of Jaw Deformities, Vol.22, No.Suppl, S23-S30, 2012.

(出版サイトへのリンク): ● Publication site (DOI): 10.5927/jjjd.22.S23
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679429660032; ● Search Scopus @ Elsevier (DOI): 10.5927/jjjd.22.S23

(DOI: 10.5927/jjjd.22.S23, CiNii: 1390282679429660032) Shingo Kuroda and Eiji Tanaka :
Skeletal anchorage facilitates the treatment of jaw deformities with vertical discrepancy: its application and limitations,
The Japanese Journal of Jaw Deformities, Vol.22, No.Suppl, S45-S50, 2012.

(出版サイトへのリンク): ● Publication site (DOI): 10.5927/jjjd.22.S45
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679429663232; ● Search Scopus @ Elsevier (DOI): 10.5927/jjjd.22.S45

(DOI: 10.5927/jjjd.22.S45, CiNii: 1390282679429663232) Keiichiro Watanabe, Shingo Kuroda, Takumi Takahashi, Takeshi Kijima, Katsuyuki Torikai, Keiji Moriyama and Eiji Tanaka :
Segmental distraction osteogenesis with modified LeFort II osteotomy for a patient with craniosynostosis,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.142, No.5, 698-709, 2012.

(要約): In this article, we report successful orthodontic treatment combined with segmental distraction osteogenesis after a modified LeFort II osteotomy in a patient with craniosynostosis. An 8-year-old boy diagnosed with craniosynostosis had a dished-in face, an anterior crossbite, and a skeletal Class III jaw relationship because of midfacial hypoplasia. At the age of 13 years 6 months, the maxillary second and mandibular first premolars were extracted, and leveling and alignment of both arches was started with preadjusted edgewise appliances. At age 14 years 11 months, the patient had a modified LeFort II osteotomy, and the maxillary segment was advanced 7 mm and fixed to the zygomatic bone. At the same time, segmental distraction osteogenesis was started with a rigid external distraction system, and the nasal segment was advanced for 20 days at a rate of 1.0 mm per day. The total active treatment period was 40 months. As a result of the modified segmental distraction osteogenesis, significant improvement of his severe midfacial hypoplasia was achieved without excessive advancement of the maxillary dentition. Both the facial profile and the occlusion were stable after 1 year of retention. However, the nasal segment relapsed 1.4 mm during the 1.5 years after the segmental distraction osteogenesis. Evaluation of the stability and retention suggests that some overcorrection in midfacial advancement is recommended.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2012.07.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23116511; ● Search Scopus @ Elsevier (PMID): 23116511; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2012.07.007

(DOI: 10.1016/j.ajodo.2012.07.007, PubMed: 23116511) 天知良太, 堀内信也, 川合暢彦, 木内奈央, 藤原慎視, 黒田晋吾, 田中栄二 :
三次元デジタルモデルを用いた片側性口唇裂口蓋裂患者の咬合評価に関する検討,
日本口蓋裂学会雑誌, Vol.37, No.3, 203-209, 2012年.

(徳島大学機関リポジトリ): ● Metadata: 106083
(出版サイトへのリンク): ● Publication site (DOI): 10.11224/cleftpalate.37.203
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11224/cleftpalate.37.203

(徳島大学機関リポジトリ: 106083, DOI: 10.11224/cleftpalate.37.203) Kyoko Ishimoto, Takeo Iwata, Hisaaki Taniguchi, Noriko Mizusawa, Eiji Tanaka and Katsuhiko Yoshimoto :
d-Dopachrome tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes.,
Cytokine, Vol.60, 772-777, 2012.

(要約): We previously identified d-dopachrome tautomerase (DDT) as a novel adipokine whose mRNA levels in adipocytes are negatively correlated with obesity-related clinical parameters, and which acts on adipocytes to regulate lipid metabolism. Here we investigated functions of DDT on preadipocytes. Recombinant DDT (rDDT) enhanced both the expression and secretion of interleukin-6 (IL-6) in SGBS cells, a human preadipocyte cell line. Treatment with rDDT increased levels of phosphorylated ERK1/2, but not p38, in SGBS cells, and rDDT-induced IL-6 mRNA expression was attenuated by pretreatment with an ERK inhibitor, U0126. Knockdown of CD74, but not CD44, inhibited rDDT-induced IL-6 mRNA expression in SGBS cells. These results suggested that the rDDT-induced IL-6 expression in preadipocytes occurred through the CD74-ERK pathway. Furthermore, in SGBS cells subjected to adipogenic induction, rDDT decreased the amount of triacylglycerol, number of cells with oil droplets, and levels of mRNA encoding adipocyte marker proteins. Increased expression of CCAAT/enhancer binding protein families and peroxisome proliferator-activated receptor 2 during adipogenesis was inhibited in the cells treated with rDDT. These results suggested DDT to inhibit adipogenesis by suppressing the expression of genes encoding adipogenic regulators in preadipocytes.
(徳島大学機関リポジトリ): ● Metadata: 109657
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.cyto.2012.07.037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22951300; ● Search Scopus @ Elsevier (PMID): 22951300; ● Search Scopus @ Elsevier (DOI): 10.1016/j.cyto.2012.07.037

(徳島大学機関リポジトリ: 109657, DOI: 10.1016/j.cyto.2012.07.037, PubMed: 22951300) 塩田智子, 藤原慎視, 中村竜也, 桂智子, 田中栄二 :
アンキローシスを伴う歯に対して外科的亜脱臼後の牽引処置を行った一症例,
中·四国矯正歯科学会雑誌, Vol.24, No.1, 45-52, 2012年. 森博世, 内田玲子, 泰江章博, 田中栄二 :
徳島大学病院矯正歯科における顎変形症患者の臨床統計学的検討,
中·四国矯正歯科学会雑誌, Vol.24, No.1, 91-96, 2012年. Eiji Tanaka, Eizo Yamano, Toshihiro Inubushi and Shingo Kuroda :
Management of acquired open bite associated with temporomandibular joint osteoarthritis using miniscrew anchorage,
Korean Journal of Orthodontics, Vol.42, No.3, 144-155, 2012.

(要約): This article reports the orthodontic treatment of a patient with skeletal mandibular retrusion and an anterior open bite due to temporomandibular joint osteoarthritis (TMJ-OA) using miniscrew anchorage. A 46-year-old woman had a Class II malocclusion with a retropositioned mandible. Her overjet and overbite were 7.0 mm and -1.6 mm, respectively. She had limited mouth opening, TMJ sounds, and pain. Condylar resorption was observed in both TMJs. Her TMJ pain was reduced by splint therapy, and then orthodontic treatment was initiated. Titanium miniscrews were placed at the posterior maxilla to intrude the molars. After 2 years and 7 months of orthodontic treatment, an acceptable occlusion was achieved without any recurrence of TMJ symptoms. The retropositioned mandible was considerably improved, and the lips showed less tension upon lip closure. The maxillary molars were intruded by 1.5 mm, and the mandible was subsequently rotated counterclockwise. Magnetic resonance imaging of both condyles after treatment showed avascular necrosis-like structures. During a 2-year retention period, an acceptable occlusion was maintained without recurrence of the open bite. In conclusion, correction of open bite and clockwise-rotated mandible through molar intrusion using titanium miniscrews is effective for the management of TMJ-OA with jaw deformity.
(出版サイトへのリンク): ● Publication site (DOI): 10.4041/kjod.2012.42.3.144
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23112945; ● Search Scopus @ Elsevier (PMID): 23112945; ● Search Scopus @ Elsevier (DOI): 10.4041/kjod.2012.42.3.144

(DOI: 10.4041/kjod.2012.42.3.144, PubMed: 23112945) Yuko Tomita, Shingo Kuroda, Tomoko Kataura, Teppei Watanabe, Keiichiro Watanabe, Shinji Fujihara and Eiji Tanaka :
Severity of alveolar cleft before palatoplasty affects vertical maxillofacial growth in 6-year-old patients with complete unilateral cleft lip and palate.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.141, No.4 Suppl, S102-9, 2012.

(要約): In this study, we investigated the association between the severity of alveolar clefts in infants and the succeeding maxillofacial growth in patients affected by complete unilateral cleft lip and palate. The subjects were 35 nonsyndromic patients affected by unilateral cleft lip and palate (n = 27) or bilateral cleft lip and palate (n = 8). Plaster models and lateral cephalograms taken at 6 years of age were analyzed and compared with the Japanese norms. In the unilateral cleft lip and palate patients, the relationship between the width of the alveolar cleft before palatoplasty and the skeletal characteristics was also explored. Significant deficiencies of the posterior maxilla and steep palatal planes were noted in both the unilateral and bilateral cleft lip and palate patients. However, they were not clearly observed in the unilateral cleft lip and palate patients born with a small alveolar cleft and were correlated with the severity of alveolar cleft in infancy. Neither cleft type nor the severity of the alveolar cleft was implicated in the maxillary arch form in childhood, but the growth of the alveolar height on the cleft side was less in the unilateral cleft lip and palate patients born with a large alveolar cleft. The severity of the alveolar cleft before palatoplasty affects the succeeding vertical maxillofacial growth in patients affected by unilateral cleft lip and palate; this suggests the necessity of a different diagnosis and treatment in unilateral cleft lip and palate patients according to the severity of the alveolar cleft in infancy.
(キーワード): Alveolar Process / 分散分析 (analysis of variance) / Case-Control Studies / Cephalometry / 子ども (children) / Child, Preschool / Cleft Lip / Cleft Palate / Dental Arch / Dental Models / Female / Humans / Imaging, Three-Dimensional / Male / Maxilla / Maxillofacial Development / Models, Anatomic / Palate, Hard / Reference Values / Severity of Illness Index / Statistics, Nonparametric / Vertical Dimension
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2011.09.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22449590; ● Summary page in Scopus @ Elsevier: 2-s2.0-84859083500

(DOI: 10.1016/j.ajodo.2011.09.010, PubMed: 22449590, Elsevier: Scopus) Shingo Kuroda, Yasuko Kuroda, Yuko Tomita and Eiji Tanaka :
Long-term stability of conservative orthodontic treatment in a patient with rheumatoid arthritis and severe condylar resorption.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.141, No.3, 352-362, 2012.

(要約): Rheumatoid arthritis is a chronic inflammatory condition that can result in progressive destruction of the articular surfaces of the joints, including the temporomandibular joint. The purpose of this article is to report the conservative correction of a Class II malocclusion in a woman with rheumatoid arthritis. The patient was 32 years 6 months old at the start of treatment. She had a convex profile and a skeletal Class II jaw-base relationship caused by severe condylar resorption. An anterior open bite of -2.0 mm and an excessive overjet of 10.0 mm were observed. Severe crowding was shown in the mandibular incisors. After 8 months of splint therapy, all first premolars were extracted, and 0.018-in preadjusted edgewise appliances were placed in both arches. Class II elastics were used during space closure. After 41 months of active orthodontic treatment, an acceptable occlusion was achieved, and the facial profile was considerably improved. From the cephalometric evaluations, the mandible was rotated counterclockwise, and the mandibular plane angle was significantly decreased. However, the anteroposterior position of the chin was not changed. The condylar resorption was not changed during and after orthodontic treatment. Conclusively, the proper facial profile was maintained, and the occlusion was stable after a 5-year retention period. Our results suggest the possibility of compromised treatment in a Class II malocclusion with an anterior open bite because of rheumatoid arthritis.
(キーワード): Adult / Arthritis, Rheumatoid / Bicuspid / Bone Resorption / Cephalometry / Female / Follow-Up Studies / Humans / Incisor / Malocclusion, Angle Class II / Mandible / Mandibular Condyle / Mandibular Diseases / Occlusal Splints / Open Bite / Orthodontic Space Closure / Overbite / Retrognathia / Rotation / Temporomandibular Joint Disorders / Tooth Extraction / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2010.04.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22381496; ● Search Scopus @ Elsevier (PMID): 22381496; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2010.04.036

(DOI: 10.1016/j.ajodo.2010.04.036, PubMed: 22381496) Shingo Kuroda, Rima Wazen, Pierre Moffatt, Eiji Tanaka and Antonio Nanci :
Mechanical stress induces bone formation in the maxillary sinus in a short-term mouse model.,
Clinical Oral Investigations, Vol.17, No.1, 131-137, 2012.

(要約): OBJECTIVES: Clinicians occasionally face the challenge of moving a tooth through the maxillary sinus. The objective of this study was to evaluate tissue remodeling during tooth movement into the maxillary sinus, more specifically as regards to bone formation. MATERIALS AND METHODS: The maxillary first molar of 20 male mice was moved toward the palatal side by a nickel-titanium super elastic wire for 1 to 14 days, and the bone remodeling around the root was evaluated using histomorphometry and immunodetection of bone-restricted Ifitm-like (Bril) protein, a novel marker of active bone formation. RESULTS: When mechanical stress was applied to the tooth, the periodontal ligament on the palatal side was immediately compressed to approximately half of its original width by the tipping movement of the tooth. At the same time, osteoblasts deposited new bone on the wall of the maxillary sinus prior to bone resorption by osteoclasts on the periodontal side, as evidenced by the high level of expression of Bril at this site. As a result of these sequential processes, bone on the sinus side maintained a consistent thickness during the entire observation period. No root resorption was observed. CONCLUSIONS: Bone formation on the surface of the maxillary sinus was evoked by mechanotransduction of mechanical stress applied to a tooth over a 2-week period, and was induced ahead of bone resorption on the periodontal ligament side. CLINICAL RELEVANCE: Mechanical stress can be exploited to induce bone formation in the maxillary sinus so that teeth can be moved into the sinus without losing bone or causing root damage.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00784-012-0686-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22373776; ● Search Scopus @ Elsevier (PMID): 22373776; ● Search Scopus @ Elsevier (DOI): 10.1007/s00784-012-0686-4

(DOI: 10.1007/s00784-012-0686-4, PubMed: 22373776) Takuya Seike, Ichiro Hashimoto, Kazuya Matsumoto, Eiji Tanaka and Hideki Nakanishi :
Early postoperative evaluation of secondary bone grafting into the alveolar cleft and its effects on subsequent orthodontic treatment,
The Journal of Medical Investigation : JMI, Vol.59, No.1,2, 152-165, 2012.

(要約): Alveolar bone grafting is a standard procedure used to achieve good occlusion for both functional and aesthetic purposes in patients with cleft lip and palate. At the past, main methods used to evaluate bone bridge formation after bone grafting are radiographs, such as dental, occlusal, and panoramic. To evaluate bone bridge both qualitatively and quantitatively, we used CT scans (conventional and QCT). Quantitative computed tomography (QCT) has previously been used for measuring bone mineral density of the lumbar vertebrae. The study comprised 26 male and 15 female patients who underwent alveolar bone grafting. We analyzed bone bridge with regard to four factors: marginal bone level, vertical height, anteroposterior bone width and bone mineral density using dental radiographs, and CT scans such as conventional and QCT. The clinical results of orthodontic treatment were evaluated more than 2 years postoperatively. Orthodontic treatment was considered to be successful when the bone bridge satisfied the following criteria: marginal bone level >= 3, vertical height >= 6.5 mm, anteroposterior bone width >= 5 mm, and bone mineral density < 350 mg Ca(5) (PO(4)) OH/mL. we could predict the prognosis of patients' orthodontic treatment in early stage after bone grafting.
(キーワード): Adult / Alveolar Process / Bone Transplantation / 子ども (children) / Cleft Palate / Female / Humans / Ilium / Male / Orthodontics / Phantoms, Imaging / Postoperative Complications / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 106017
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.59.152
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22450004; ● Search Scopus @ Elsevier (PMID): 22450004; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.152

(徳島大学機関リポジトリ: 106017, DOI: 10.2152/jmi.59.152, PubMed: 22450004) Tatsuya Nakamura, Shinji Fujihara, Kumiko Nagata, Tomoko Kataura, Toshihiro Inubushi and Eiji Tanaka :
Low-Intensity Pulsed Ultrasound Reduces the Inflammatory Activity of Synovitis.,
Annals of Biomedical Engineering, Vol.39, No.12, 2964-2971, 2011.

(要約): The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on the cell proliferation and growth of synovial membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis. The rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with or without IL-1β or TNF-α. Four hours after stimulation with the cytokines, the cells received LIPUS or sham exposure. Cell proliferation and growth were then analyzed. Using MRL/lpr mice, the anti-inflammatory effects of LIPUS were also evaluated in vivo. Stimulation with proinflammatory cytokines significantly up-regulated cell proliferation which was significantly down-regulated by LIPUS exposure. In MRL/lpr mice, exposure of knee joints to LIPUS caused a significant reduction of histological damage compared to the control. Histological lesions were significantly reduced in the joints treated with LIPUS for 3 weeks. Cox-2-positive cells in the knee joints treated with LIPUS were markedly decreased compared to the control joints. Therefore, LIPUS stimulation may be a medical treatment for joint inflammatory diseases, such as synovitis.
(キーワード): Animals / Arthritis, Rheumatoid / Cell Line / Cyclooxygenase 2 / Disease Models, Animal / Humans / Interleukin-1beta / Knee Joint / Male / Mice / Rabbits / Synovial Membrane / Synovitis / Tumor Necrosis Factor-alpha / Ultrasonic Therapy
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-011-0408-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21938555; ● Search Scopus @ Elsevier (PMID): 21938555; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-011-0408-0

(DOI: 10.1007/s10439-011-0408-0, PubMed: 21938555) Shingo Kuroda, Keiichiro Watanabe, Kyoko Ishimoto, Hideki Nakanishi, Keiji Moriyama and Eiji Tanaka :
Long-term stability of LeFort III distraction osteogenesis with a rigid external distraction device in a patient with Crouzon syndrome.,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.140, No.4, 550-561, 2011.

(要約): A 6-year-old boy, diagnosed with Crouzon syndrome, had moderate exorbitism, a concave profile, an anterior crossbite of -4.0 mm, and a skeletal Class III jaw-base relationship caused by midfacial hypoplasia. At age 8 years 9 months, a LeFort III osteotomy was performed, and distraction osteogenesis was immediately started with the rigid external distractor system. The midface was advanced approximately 10.0 mm for 6 days, including overcorrection. After the distraction, a reverse headgear was used for 6 years to prevent relapse and to accelerate expected growth. At age 16 years 5 months, after extraction of the maxillary first premolars and mandibular third molars, 0.022-in preadjusted edgewise brackets were placed to treat the edge-to-edge incisor relationship and minor crowding. After 13 months of treatment, the facial profile was significantly improved, and an acceptable occlusion was achieved. During the 9-year observation period after the distraction, acceptable facial growth occurred, and no relapse of the maxillary advancement was observed. However, syndrome-specific growth and methodologically induced relapse should be considered when planning a LeFort III distraction in children for the treatment of Crouzon syndrome.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2009.12.038
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21967944; ● Search Scopus @ Elsevier (PMID): 21967944; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2009.12.038

(DOI: 10.1016/j.ajodo.2009.12.038, PubMed: 21967944) M. J. Lamela, Y. Prado, P. Fernández, A. Fernández-Canteli and Eiji Tanaka :
Non-linear Viscoelastic Model for Behaviour Characterization of Temporomandibular Joint Discs,
Experimental Mechanics, Vol.51, No.8, 1435-1440, 2011.

(要約): Generally, the complex behaviour of the disc ofthe temporomandibular joint (TMJ) cannot be adequatelyrepresented using linear elastic or linear viscoelasticmodels. Since the disc is regularly subjected to large strainand stress levels, the study of its non-linear response undercompression is of practical interest, especially for analysisof medical dysfunctions. With this aim, relaxation andcreep tests were carried out using round specimens ofdiameters ranging between 4 and 6 mm cut off from thecentral, anterior, posterior, lateral and medial zones ofporcine discs to investigate the regional mechanicalproperties differences. The experimental data results arefitted using Prony series, based on generalized Maxwelland Kelvin models, allowing the relaxation and creepmoduli to be represented, respectively, as a function of thestrain and stress. The results show that the non-linearmaterial behaviour of this biological tissue is properlydescribed by the proposed models, to be consideredsubsequently in numerical calculations.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11340-011-9465-4
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/s11340-011-9465-4

(DOI: 10.1007/s11340-011-9465-4) Teppei Watanabe, Akihiro Yasue, Shinji Fujihara and Eiji Tanaka :
PERIOSTIN regulates MMP-2 expression via the αvβ3 integrin/ERK pathway in human periodontal ligament cells.,
Archives of Oral Biology, Vol.57, No.1, 52-59, 2011.

(要約): OBJECTIVE: During orthodontic tooth movement, activation of the vascular system in the compressed periodontal ligament (PDL), which becomes hypoxic, is essential for periodontal tissue remodelling. PERIOSTIN, an extracellular matrix protein, is expressed in PDL and its concentration is increased on the compressive side during orthodontic tooth movement. PERIOSTIN promotes angiogenesis through upregulation of matrix metalloproteinase (MMP)-2, which has been shown to be expressed via αvβ3 integrin/extracellular signal-related kinase (ERK) signalling pathway and vascular endothelial growth factor (VEGF). Therefore, we hypothesized that hypoxia-induced PERIOSTIN promotes MMP-2 expression via αvβ3 integrin/ERK signalling and VEGF in PDL cells. METHODS: Human PDL cells were cultured in condition medium containing desferrioxamine (DFO) to mimic hypoxia. The total RNA, cell lysates or supernatant were collected, and MMP2 and VEGF expression, PERIOSTIN expression and ERK phosphorylation, and MMP-2 activity were analysed by real-time RT-PCR, western blot analysis, and zymography, respectively. A recombinant human PERIOSTIN or PERIOSTIN siRNA was applied to the cells, then the total RNA was extracted to measure MMP-2 and VEGF expression. The cells were treated with αvβ3 integrin-blocking antibody or ERK inhibitor followed by PERIOSTIN stimulation. MMP-2 expression was measured by real-time RT-PCR. RESULTS: PERIOSTIN was upregulated in a time-dependent manner in human PDL cells treated with DFO, a chemical hypoxia mimic. MMP-2 and VEGF expression, and MMP-2 activity were increased by DFO or PERIOSTIN treatment, and decreased by PERIOSTIN silencing. PERIOSTIN treatment also induced ERK phosphorylation, and PERIOSTIN-induced MMP-2 was reduced by αvβ3 integrin-blocking antibody or ERK inhibitor. CONCLUSION: These data suggest that PERIOSTIN upregulates MMP-2 expression via the αvβ3 integrin/ERK signalling pathway and VEGF expression in human PDL cells.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2011.07.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21885032; ● Search Scopus @ Elsevier (PMID): 21885032; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2011.07.010

(DOI: 10.1016/j.archoralbio.2011.07.010, PubMed: 21885032) 竹内久裕, 石川輝明, 松本文博, 田中栄二, 中野雅德 :
徳島大学病院における顎関節症患者の特徴に関する調査-男女比，年齢構成と受診期間-,
日本顎関節学会雑誌, Vol.23, No.2, 83-89, 2011年.

(要約): 目的:徳島大学病院で使用している顎機能レポートシステム記録から受診患者の特徴と経過を把握し，さらに臨床サンプルにおけるバイアスの影響について検討を行うことを目的とした．対象および方法:対象は徳島大学病院を顎関節症または関連疾患で受診し，顎機能レポートシステムに記録があり，なおかつ選択基準を満たした解析対象群1,083例(男女比1:2.4)と歯科診療部門をほぼ同期間に受診した一般初診患者群24,588例(男女比1:1.4)である．解析項目は年齢構成，男女比，受診期間などである．結果および考察:解析対象群の年齢構成は15∼24歳と55∼59歳にピークのある二峰性を示した．一般初診患者群との比較では，解析対象群の15∼34歳が多い傾向を示す一方，60歳以上では少ない傾向を示し，男女比も有意に異なっていた(χ2検定:p<0.001)．年齢分布については，一般住民の年齢構成(総務省「平成17年国勢調査」)に対し一般初診患者群，解析対象群とも青壮年層で少ない傾向を示し，大学病院受診患者というサンプリングバイアスが見かけ上の二峰性を生じさせていた可能性が考えられた．経過としては90日以内で約80%，180日以内で約90%が診療終了となる一方，通院1年以上の長期症例が約5%存在した．結論:大学病院における顎関節症患者の特徴および経過について明らかにするとともに，サンプリングバイアスの影響について検討を行った．
(キーワード): 年齢分布 / 男女比 / 疫学調査 / サンプルバイアス
(出版サイトへのリンク): ● Publication site (DOI): 10.11246/gakukansetsu.23.83
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204420730496; ● Search Scopus @ Elsevier (DOI): 10.11246/gakukansetsu.23.83

(DOI: 10.11246/gakukansetsu.23.83, CiNii: 1390001204420730496) 高原一菜, 川合暢彦, 中村彩花, 松本一真, 天知良太, 渡邉佳一郎, 川上恵実, 大浦徳永律子律子, 石本恭子, 藤原慎視, 黒田晋吾, 田中栄二 :
徳島大学病院矯正歯科における患者の動向調査,
中·四国矯正歯科学会雑誌, Vol.23, No.1, 77-82, 2011年. 米田尚子, 日浅雅博, 井上雅秀, 長山智子, 吉田亮彦, 森博世, 藤原慎視, 堀内信也, 田中栄二 :
インプラント固定に関する臨床統計学的研究,
中·四国矯正歯科学会雑誌, Vol.23, No.1, 69-76, 2011年. 永田久美子, 木内奈央, 中村竜也, 渡邉哲平, 桂智子, 泰江章博, 藤原慎視, 富田優子, 田中栄二 :
過去25年間に徳島大学病院矯正歯科に来院した口唇裂・口蓋裂患者の臨床統計学的調査,
中·四国矯正歯科学会雑誌, Vol.23, No.1, 61-68, 2011年. Shingo Kuroda, R Wazen, K Sellin, Eiji Tanaka, P Moffatt and A Nanci :
Ameloblastin is not implicated in bone remodelling and repair.,
European Cells & Materials, Vol.22, 56-67, 2011.

(要約): Ameloblastin (AMBN) is an enamel matrix protein produced by ameloblasts. It has been suggested that AMBN might also be implicated in craniofacial bone formation. Our objective was to determine whether AMBN has an effect on osteogenic mineralisation and influences bone remodelling and repair. MC3T3-E1 cells were screened for endogenous expression of enamel proteins using real time PCR. Various osteogenic cells were infected with lentivirus encoding for AMBN and protein expression was verified using immunochemistry. Cultures were stained with alizarin red and mineralisation was quantified. Healing bone was probed for expression of AMBN by DNA microarray analysis. Tooth extraction, experimental tooth movement (ETM), and creation of a non-critical size bone defect in the tibia (BDT) were carried out in wild type and AMBNΔ5-6 mutant mice. Tissues were processed for immunolabelling of AMBN and Bril, an osteoblast specific protein associated with active bone formation. MC3T3-E1 cells and healing bone showed no significant expression of AMBN. Overexpression of AMBN in osteogenic cultures induced no noticeable changes in mineralisation. In wild type mice, AMBN was immunodetected in ameloblasts and enamel, but not in normal bone, and at sites where bone remodelling and repair were induced. Bone remodelling during ETM and BDT repair in AMBNΔ5-6 mice were not significantly different from that in wild type animals. Our results suggest that AMBN does not influence osteogenic activity in vitro under the conditions used, and does not participate in craniofacial bone remodelling under mechanical stress and in repair of non-critical size bone defects.
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21761392; ● Search Scopus @ Elsevier (PMID): 21761392

(PubMed: 21761392) Shinya Horiuchi, Shingo Kuroda, Masahiro Hiasa, Toshiyuki Suge, Seitaro Saku, Kenichi Hamada, Takashi Matsuo, Kenzo Asaoka and Eiji Tanaka :
Reinforcement of bond strength of self-etching orthodontic adhesive.,
The Angle Orthodontist, Vol.82, No.1, 30-35, 2011.

(要約): Abstract Objective: To determine the reinforcement of bond strength of a self-etching system by applying a pretreatment agent. Materials and Methods: Sixty extracted human premolars were used in this study. The enamel surfaces were treated with four pretreatment agents?phosphoric acid, polyacrylic acid, citric acid, and ammonium hexafluorosilicate (SiF)?and were examined under a scanning electron microscope. Afterward, orthodontic brackets were bonded with a self-etching adhesive system (n ?=? 10 for each agent), and shear bond strength was measured through a debonding process. The adhesive remnant index (ARI) was also assessed. Results: Enamel surfaces treated with polyacrylic acid seemed almost the same as intact enamel. Treatment with SiF induced slight shallow depressions compared with the intact enamel. On the other hand, enamel surfaces treated with citric acid and phosphoric acid showed severe etching patterns. All pretreatments increased the bond strength, but SiF-treated specimens revealed the greatest strength (12.201 ? 1.048?MPa), followed by polyacrylic acid (12.030 ? 2.103?MPa). The control group with no pretreatment showed the least strength (9.078 ? 1.678?MPa). All pretreatments increased ARI score compared with the control group. Conclusions: Surface conditioning before bracket adhesion could reinforce the bond strength of the self-etching adhesive system, resulting in a more reliable bonding system.
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/012011-39.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21751834; ● Search Scopus @ Elsevier (PMID): 21751834; ● Search Scopus @ Elsevier (DOI): 10.2319/012011-39.1

(DOI: 10.2319/012011-39.1, PubMed: 21751834) Shingo Kuroda and Eiji Tanaka :
Application of Temporary Anchorage Devices for the Treatment of Adult Class III Malocclusions,
Seminars in Orthodontics, Vol.17, No.2, 91-97, 2011.

(出版サイトへのリンク): ● Publication site (DOI): 10.1053/j.sodo.2010.12.002
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1053/j.sodo.2010.12.002

(DOI: 10.1053/j.sodo.2010.12.002) B E Rego, Toshihiro Inubushi, Mutsumi Miyauchi, A Kawazoe, Eiji Tanaka, Takashi Takata and Kazuo Tanne :
Ultrasound stimulation attenuates root resorption of rat replanted molars and impairs tumor necrosis factor- signaling in vitro.,
Journal of Periodontal Research, Vol.46, No.6, 648-654, 2011.

(要約): Rego EB, Inubushi T, Miyauchi M, Kawazoe A, Tanaka E, Takata T, Tanne K. Ultrasound stimulation attenuates root resorption of rat replanted molars and impairs tumor necrosis factor-α signaling in vitro. J Periodont Res 2011; 46: 648-654. © 2011 John Wiley & Sons A/S. Background and Objective: A therapeutic protocol to minimize root resorption induced by tooth replantation has not yet been universally established. In this context, noninvasive modality such as ultrasound therapy have been a focus of increased interest. This study aimed to evaluate the inhibitory effect of ultrasound therapy on root resorption of replanted rat molars. In addition, the study aimed to promote insights into the mechanism through which ultrasound mediates the metabolism of periodontal cells in vitro. Material and Methods: An experimental model of tooth replantation in rats, involving luxation and immediate replacement of the maxillary first molars, was used to assess the inhibitory effect of an ultrasound-therapy regimen (15 min of exposure to ultrasound, each day for 21 d) on root resorption. Moreover, the effect of ultrasound on osteoclastogenesis/cementoclastogenesis was examined in vitro using a mouse osteoblastic stromal cell line (ST2) and a mouse cementoblastic cell line (OCCM-30). Results: The area of root resorption lacunae was statistically decreased (p < 0.01) in the ultrasound-treated sample. In addition, immunohistochemical staining, using murine TNF-α polyclonal antibody, failed to detect tumor necrosis factor-α (TNF-α) protein in the ultrasound-treated sample compared with the control. An in vitro study showed that the lipopolysaccharide (LPS)-induced expression of Tnfalpha mRNA was significantly reduced by ultrasound therapy in both osteoblastic and cementoblastic cells. Moreover, the TNF-α-induced up-regulation of Rankl mRNA was also inhibited by ultrasound. Conclusion: Ultrasound may contribute to the reduction of the trauma-induced inflammatory reaction through impairment of the TNF-α signaling pathway. It is therefore suggested that ultrasound shows potential as a therapeutic tool to optimize the regenerative potential of periodontal tissues on replanted teeth.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1600-0765.2011.01384.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21644998; ● Search Scopus @ Elsevier (PMID): 21644998; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0765.2011.01384.x

(DOI: 10.1111/j.1600-0765.2011.01384.x, PubMed: 21644998) Kotaro Tanimoto, Takashi Kamiya, Yuki Tanne, Ryo Kunimatsu, Tomomi Mitsuyoshi, Eiji Tanaka and Kazuo Tanne :
Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage,
Cell and Tissue Research, Vol.344, No.2, 333-340, 2011.

(要約): We examined the localization and boundary lubricating function of superficial zone protein (SZP) on the surface of mandibular condylar cartilage. Chondrocytes were separated from the surface layer of mandibular condylar cartilage of 6- to 9-month-old female pigs. A cyclic tensile strain of 7% or 21% cell elongation was applied to the cultured chondrocytes. Gene expression levels of cartilage matrix proteins and secretory phospholipase A(2) (sPLA(2)) were quantified by real-time polymerase chain reaction analysis. The friction coefficient of the mandibular condylar surface was measured by a friction tester before and after treatment with 0.1 U/ml sPLA(2). Significantly higher mRNA levels of SZP and type I collagen were found in chondrocytes from the superficial layer than in those in the other layers. The SZP mRNA level was up-regulated by cyclic tensile strain of 7% and 21% cell elongation. Cyclic tensile strain of 21% cell elongation up-regulated the sPLA(2) mRNA level. The friction coefficient of the condylar surface was increased significantly by treatment with sPLA(2). The removal of SZP from the surface layer of mandibular condylar cartilage by sPLA(2) resulted in a significant increase in the friction coefficient on the surface of articular cartilage.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00441-011-1156-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21484414; ● Search Scopus @ Elsevier (PMID): 21484414; ● Search Scopus @ Elsevier (DOI): 10.1007/s00441-011-1156-z

(DOI: 10.1007/s00441-011-1156-z, PubMed: 21484414) Emi Kawakami, Nao Kinouchi, Taro Adachi, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice.,
Development Growth & Differentiation, Vol.53, No.1, 48-54, 2011.

(要約): Small interfering RNA (siRNA)-mediated silencing of gene expression is rapidly becoming a powerful tool for molecular therapy. However, the rapid degradation of siRNAs and their limited duration of activity require efficient delivery methods. Atelocollagen (ATCOL)-mediated administration of siRNAs is a promising approach to disease treatment, including muscular atrophy. Herein, we report that ATCOL-mediated systemic administration of a myostatin-targeting siRNA into a caveolin-3-deficient mouse model of limb-girdle muscular dystrophy 1C (LGMD1C) induced a marked increase in muscle mass and a significant recovery of contractile force. These results provide evidence that ATCOL-mediated systemic administration of siRNAs may be a powerful therapeutic tool for disease treatment, including muscular atrophy.
(キーワード): Animals / Caveolin 3 / Collagen / Female / Male / Mice / Muscular Atrophy / Myostatin / RNA Interference / RNA, Small Interfering
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1440-169X.2010.01221.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21261610; ● Search Scopus @ Elsevier (PMID): 21261610; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-169X.2010.01221.x

(DOI: 10.1111/j.1440-169X.2010.01221.x, PubMed: 21261610) Ritsuko 徳永律子 Oura, Shingo Kuroda, Takumi Takahashi, Yuko Tomita and Eiji Tanaka :
Efficient usage of implant anchorage in treatment of overerupted maxillary first molar and mesially inclined mandibular molars,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.139, No.1, 113-122, 2011.

(要約): This case report demonstrates the efficient use of implant anchorage in a patient with mesially inclined mandibular molars and an overerupted maxillary molar. A 14-year-old girl had an overerupted maxillary right first molar, possibly because of severely inclined mandibular right molars. Two-step use of miniplate anchorage in the right zygomatic process was proposed. As the first step, the overerupted maxillary first molar was intruded with elastic chains from the miniplate for 10 months. Then the maxillary right molars were distalized by using the miniplate to correct the Class II molar relationship. In the mandible, the first molar was extruded with intermaxillary elastics applied from the miniplate to the molar for 7 months after the uprighting of the mandibular right second molar. The results suggest that the use of 2-step implant anchorage is efficient for intrusion and distalization of maxillary molars and extrusion and uprighting of mandibular inclined molars.
(キーワード): Adolescent / Bone Plates / Cephalometry / Dental Implants / Female / Follow-Up Studies / Humans / Malocclusion / Mandible / Maxilla / Molar / Orthodontic Anchorage Procedures / Orthodontic Appliance Design / Orthodontic Extrusion / Patient Care Planning / Tooth Eruption / 歯の運動 (tooth movement) / Treatment Outcome / Zygoma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2009.05.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21195284; ● Search Scopus @ Elsevier (PMID): 21195284; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2009.05.025

(DOI: 10.1016/j.ajodo.2009.05.025, PubMed: 21195284) 田中栄二 :
顎関節症患者に対する矯正歯科治療ー長期経過例ー,
日本成人矯正歯科学会雑誌, Vol.17, No.1, 38-51, 2010年. Akira Nakajima, Eiji Tanaka, Yoshihiro Ito, Masao Maeno, Koichi Iwata, Noriyoshi Shimizu and F Charles Shuler :
The expression of TGF-β3 for epithelial-mesenchyme transdifferentiated MEE in palatogenesis.,
Journal of Molecular Histology, Vol.41, No.6, 343-355, 2010.

(要約): The fate of the palatal medial edge epithelial (MEE) cells undergoes programming cell death, migration, and epithelial-mesenchymal transdifferentiation (EMT) coincident with the process of palatal fusion and disappearance of MEE. Mesenchymal cells in the palate have both cranial neural crest (CNC) and non-CNC origins. The objectives of this study were to identify the populations of palatal mesenchymal cells using β-galactosidase (β-gal) and DiI cell lineage markers, and to determine whether MEE-derived cells continued to express transforming growth factor-β3 (TGF-β3) and transforming growth factor-β type III receptor (TβR-III), which were specific for MEE. A model has been developed using Wnt1 tissue specific expression of Cre-recombinase to activate β-gal solely in the CNC. The expressions of TGF-β3 and TβR-III in MEE were temporally correlated with critical events in palatogenesis. Three cell populations could be distinguished in the palatal mesenchymal CNC-derived, non-CNC derived and MEE-derived. After fusion, β-gal^- and DiI+ mesenchymal cells continued to express TGF-β3, however TβR-III was expressed only in the epithelial MEE, as well as keratin expression. In addition, we performed laser capture microdissection to identify mRNA expression of isolated DiI+ MEE cells. Both epithelial and transdifferentiated MEE have expressed TGF-β3, however, TβR-III was only expressed in epithelium. Extracellular matrix, especially MMP13 has been expressed coincident with fused stage which can be strongly associated with TGF-β3. These results demonstrate that combining a heritable marker and a cell lineage dye can distinguish different populations of mesenchymal cells in the developing palate. Furthermore, TGF-β3 and MMP13 could be strongly associated with EMT in palatogenesis.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10735-010-9296-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20967564; ● Search Scopus @ Elsevier (PMID): 20967564; ● Search Scopus @ Elsevier (DOI): 10.1007/s10735-010-9296-0

(DOI: 10.1007/s10735-010-9296-0, PubMed: 20967564) Tatsuya Nakamura, Shinji Fujihara, Tomoko Kataura, Kumiko Yamamoto, Toshihiro Inubushi, Kotaro Tanimoto and Eiji Tanaka :
Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells.,
Annals of Biomedical Engineering, Vol.38, No.11, 3363-3370, 2010.

(要約): The purpose of this study is to examine effects of low-intensity pulsed ultrasound (LIPUS) on metabolism of hyaluronan (HA) in synovial membrane cells stimulated by IL-1β. Rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with the presence or absence of 1 ng/mL IL-1β, and after 4 h the cell was exposed to LIPUS for 15 min. The mRNA levels of HA synthase (HAS) 2,3, hyaluronidase (HYAL) 2, and cyclooxygenase (COX)-2 were examined by real-time PCR analysis. Concentrations of HA and PGE₂ were quantified by use of enzyme linked immunosorbent assay (ELISA). The COX-2 level was analyzed by western blotting. Gene levels of HAS2 and HAS3 in IL-1β-stimulated cells were up-regulated significantly (p < 0.01) by LIPUS. HYAL2 mRNA was up-regulated by the treatment with IL-1β, whereas down-regulated significantly (p < 0.01) by the following LIPUS exposure. Furthermore, IL-1β stimulation enhanced COX-2 and PGE₂ expression as compared to the untreated control, and IL-1β-induced COX-2 and PGE₂ expression was inhibited by LIPUS. These results suggest that LIPUS enhanced HA synthesis and inhibited HYAL2 expression, leading to the accumulation of high-molecular weight HA. Therefore, LIPUS stimulation may be a better candidate as medical remedy to treat inflammatory joint diseases accompanied with HA degradation in synovial fluid.
(キーワード): Animals / Arthritis / Cell Line / Cyclooxygenase 2 / Dinoprostone / Gene Expression Regulation / Glucuronosyltransferase / Hyaluronoglucosaminidase / Interleukin-1beta / Knee Joint / Rabbits / Sound / Synovial Membrane / Time Factors / Ultrasonic Therapy / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-010-0104-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20571855; ● Summary page in Scopus @ Elsevier: 2-s2.0-78149285438

(DOI: 10.1007/s10439-010-0104-5, PubMed: 20571855, Elsevier: Scopus) Hiroko Mori, Shinya Horiuchi, Satoshi Nishimura, Hiroki Nikawa, Takeshi Murayama, Kanji Ueda, Daiichi Ogawa, Shingo Kuroda, Fumiaki Kawano, Hisashi Naito, Masao Tanaka, Harm Jan Koolstra and Eiji Tanaka :
Three-dimensional finite element analysis of cartilaginous tissues in human temporomandibular joint during prolonged clenching.,
Archives of Oral Biology, Vol.55, No.11, 879-886, 2010.

(要約): OBJECTIVE: Bruxism, the parafunctional habit of nocturnal grinding of the teeth and clenching, is associated with the onset of joint degeneration. Especially prolonged clenching is suggested to cause functional overloading in the temporomandibular joint (TMJ). In this study, the distributions of stresses in the cartilaginous TMJ disc and articular cartilage, were analysed during prolonged clenching. The purpose of this study was to examine if joint degradation due to prolonged clenching can be attributed to changes in stress concentration in the cartilaginous tissues. DESIGN: Finite element model was developed on the basis of magnetic resonance images from a healthy volunteer. Condylar movements recorded during prolonged clenching were used as the loading condition for stress analysis. RESULTS: At the onset of clenching (time=0s), the highest von Mises stresses were located in the middle and posterior areas (6.18MPa) of the inferior disc surface facing the condylar cartilage. The largest magnitude of the minimum principal stress (-6.72MPa) was found in the condylar cartilage. The stress concentrations were relieved towards the superior disc surface facing the temporal cartilage. On the surfaces of the temporal cartilage, relatively lower stresses were found. After 5-min clenching, both stress values induced in the TMJ components were reduced to 50-80% of the stress values at the onset of clenching, although the concomitant strains increased slightly during this period. CONCLUSIONS: It is suggested that both the condylar and temporal cartilage layers along with the TMJ disc, play an important role in stress distribution and transmission during prolonged clenching due to tissue expansion. Furthermore, our study suggests that a development of stress concentrations in the TMJ during prolonged clenching and risk factors for the initiation of TMJ degeneration could not be confirmed.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2010.07.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20728866; ● Search Scopus @ Elsevier (PMID): 20728866; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2010.07.011

(DOI: 10.1016/j.archoralbio.2010.07.011, PubMed: 20728866) Taro Adachi, Emi Kawakami, Naozumi Ishimaru, Takahiro Ochiya, Yoshio Hayashi, Hideyo Ohuchi, Masao Tanihara, Eiji Tanaka and Sumihare Noji :
Delivery of small interfering RNA with a synthetic collagen poly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo.,
Development Growth & Differentiation, Vol.52, No.8, 693-699, 2010.

(要約): Silencing gene expression by small interfering RNAs (siRNAs) has become a powerful tool for the genetic analysis of many animals. However, the rapid degradation of siRNA and the limited duration of its action in vivo have called for an efficient delivery technology. Here, we describe that siRNA complexed with a synthetic collagen poly(Pro-Hyp-Gly) (SYCOL) is resistant to nucleases and is efficiently transferred into cells in vitro and in vivo, thereby allowing long-term gene silencing in vivo. We found that the SYCOL-mediated local application of siRNA targeting myostatin, coding a negative regulator of skeletal muscle growth, in mouse skeletal muscles, caused a marked increase in the muscle mass within a few weeks after application. Furthermore, in vivo administration of an anti-luciferase siRNA/SYCOL complex partially reduced luciferase expression in xenografted tumors in vivo. These results indicate a SYCOL-based non-viral delivery method could be a reliable simple approach to knockdown gene expression by RNAi in vivo as well as in vitro.
(キーワード): Animals / Base Sequence / Cell Line, Tumor / Collagen / DNA Primers / Gene Silencing / Mice / RNA, Small Interfering / Reverse Transcriptase Polymerase Chain Reaction
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1440-169X.2010.01206.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20874713; ● Search Scopus @ Elsevier (PMID): 20874713; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-169X.2010.01206.x

(DOI: 10.1111/j.1440-169X.2010.01206.x, PubMed: 20874713) Yuko Tomita, Shingo Kuroda, Hideki Nakanishi and Eiji Tanaka :
Severity of alveolar cleft affects prognosis of infant orthopedics in complete unilateral cleft lip and palate: three-dimensional evaluation from cheiloplasty to palatoplasty.,
The Journal of Craniofacial Surgery, Vol.21, No.5, 1503-1507, 2010.

(要約): The purpose of this study was to investigate the relationships between severity of alveolar cleft and treatment outcome of infant orthopedics in patients affected by complete unilateral cleft lip and palate from cheiloplasty to palatoplasty with a three-dimensional evaluation method. Treatment outcomes of infant orthopedics were evaluated using three-dimensional linear and angular measurements of plaster models after cheiloplasty (T1) and before palatoplasty (T2). Eleven patients who had a width of alveolar cleft (WC) less than 4.0 mm at T1 (mild group) and 13 patients who had a WC 4.0 mm or greater (severe group) were compared and analyzed. From T1 to T2, the lengths of the alveolar segments were increased, and the WC was decreased without palatal collapse of alveolar segments in both groups. However, the WC in the severe group was significantly decreased by increased growth of the major segment compared with the mild group. The incisive papilla had a more evoked growth to the alveolar cleft side than in the severe group. Conclusively, infant orthopedics was quite useful in reducing WC in patients affected by unilateral cleft lip and palate after cheiloplasty, and the severity of WC significantly affected the prognosis of infant orthopedics.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/SCS.0b013e3181ef2c06
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20818240; ● Search Scopus @ Elsevier (PMID): 20818240; ● Search Scopus @ Elsevier (DOI): 10.1097/SCS.0b013e3181ef2c06

(DOI: 10.1097/SCS.0b013e3181ef2c06, PubMed: 20818240) 野地澄晴, 足立太郎, 川上恵実, 田中栄二 :
RNA干渉法による治療を実現するための研究,
中·四国矯正歯科学会雑誌, Vol.22, No.1, 3-8, 2010年. 田中栄二 :
顎顔面成長に対する咀嚼の重要性,
中·四国矯正歯科学会雑誌, Vol.22, No.1, 9-16, 2010年. 松本一真, 川合暢彦, 井澤俊, 藤原慎視, 中村彩花, 大浦徳永律子律子, 高原一菜, 日浅雅博, 田中栄二 :
Oligodontiaを伴う著しい過蓋咬合に対する包括的治療例,
中·四国矯正歯科学会雑誌, Vol.22, No.1, 49-56, 2010年. 松田りえ, 堀内信也, 川上恵実, 森博子, 田中栄二 :
顔面骨骨折による咬合不全に対し，急速拡大装置を逆回転することで整復した1症例,
中·四国矯正歯科学会雑誌, Vol.22, No.1, 27-34, 2010年. 中村竜也, 藤原慎視, 桂智子, 泰江章博, 田中栄二 :
Dynamic positioner with facebowを用いて治療を行ったアングルⅡ級1類の2症例,
中·四国矯正歯科学会雑誌, Vol.22, No.1, 35-48, 2010年. 森博子, 森泰正, 中村彩花, 川合暢彦, 田中栄二 :
上顎歯槽基底弓幅径と聴力との関係,
四国歯学会雑誌, Vol.23, No.1, 61-64, 2010年.

(徳島大学機関リポジトリ): ● Metadata: 109800

(徳島大学機関リポジトリ: 109800) Nobuhiko Kawai, Ryota Sano, M Joannes A Korfage, Saika Nakamura, Nao Kinouchi, Emi Kawakami, Kazuo Tanne, J Geerling E Langenbach and Eiji Tanaka :
Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency: an immunohistochemical and electromyographic study.,
Journal of Anatomy, Vol.216, No.6, 717-723, 2010.

(要約): The development of the craniofacial system occurs, among other reasons, as a response to functional needs. In particular, the deficiency of the proper masticatory stimulus affects the growth. The purpose of this study was to relate alterations of muscle activity during postnatal development to adaptational changes in the muscle fibers. Fourteen 21-day-old Wistar strain male rats were randomly divided into two groups and fed on either a solid (hard-diet group) or a powder (soft-diet group) diet for 63 days. A radio-telemetric device was implanted to record muscle activity continuously from the superficial masseter, anterior belly of digastric and anterior temporalis muscles. The degree of daily muscle use was quantified by the total duration of muscle activity per day (duty time), the total burst number and their average length exceeding specified levels of the peak activity (5, 20 and 50%). The fiber type composition of the muscles was examined by the myosin heavy chain content of fibers by means of immunohistochemical staining and their cross-sectional area was measured. All muscle fibers were identified as slow type I and fast type IIA, IIX or IIB (respectively, with increasing twitch contraction speed and fatigability). At lower activity levels (exceeding 5% of the peak activity), the duty time of the anterior belly of the digastric muscle was significantly higher in the soft-diet group than in the hard-diet group (P < 0.05). At higher activity levels (exceeding 20 and 50% of the peak activity), the duty time of the superficial masseter muscle in the soft-diet group was significantly lower than that in the hard-diet group (P < 0.05). There was no difference in the duty time of the anterior temporalis muscle at any muscle activity level. The percentage of type IIA fibers of the superficial masseter muscle in the soft-diet group was significantly lower than that in the hard-diet group (P < 0.01) and the opposite was true with regard to type IIB fibers (P < 0.05). The cross-sectional area of type IIX and type IIB fibers of the superficial masseter muscle was significantly smaller in the soft-diet group than in the hard-diet group (P < 0.05). There was no difference in the muscle fiber composition and the cross-sectional area of the anterior belly of the digastric and anterior temporalis muscles. In conclusion, for the jaw muscles of male rats reared on a soft diet, the slow-to-fast transition of muscle fiber was shown in only the superficial masseter muscle. Therefore, the reduction in the amount of powerful muscle contractions could be important for the slow-to-fast transition of the myosin heavy chain isoform in muscle fibers.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1469-7580.2010.01235.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20579175; ● Search Scopus @ Elsevier (PMID): 20579175; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7580.2010.01235.x

(DOI: 10.1111/j.1469-7580.2010.01235.x, PubMed: 20579175) Braga Emanuel Rego, Toshihiro Inubushi, Aki Kawazoe, Kotaro Tanimoto, Mutsumi Miyauchi, Eiji Tanaka, Takashi Takata and Kazuo Tanne :
Ultrasound stimulation induces PGE(2) synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway.,
Ultrasound in Medicine & Biology, Vol.36, No.6, 907-915, 2010.

(要約): The present study aims to provide insights into how ultrasound treatment (US) can affect the regenerative response of cementum by evaluating the role of prostaglandin E(2) induced by ultrasound stimulation on cementoblastic differentiation. The mouse cementoblast cell line OCCM-30 was exposed to low-intensity ultrasound and the cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin E(2) (PGE(2)) production were quantified. The role of the US-induced PGE(2) in mineralization was examined using COX-2 inhibitor and prostaglandin receptors (EP-receptors) agonists and antagonists. In addition, gene expression of differentiation markers related to mineral metabolism was evaluated. Ultrasound significantly enhanced COX-2 mRNA expression and PGE(2) production. PGE(2) induced by US mediated mineral nodule formation, whereas COX-2 inhibitor treatment eliminated the enhancement of mineralization induced by US stimulation. Mineral deposition was also inhibited by treatment with EP2 or EP4 antagonist. Moreover, up-regulation of differentiation markers induced by US was suppressed by treatment with COX-2 inhibitor. The present findings provide evidence that US stimulation has a positive effect on mineralization ability of cementoblasts through the activation of EP2/EP4 pathway, suggesting that US can be a promising therapeutic tool for cementum repair.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ultrasmedbio.2010.03.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20447753; ● Search Scopus @ Elsevier (PMID): 20447753; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ultrasmedbio.2010.03.008

(DOI: 10.1016/j.ultrasmedbio.2010.03.008, PubMed: 20447753) Kotaro Tanimoto, T Yanagida, Y Tanne, T Kamiya, Y-C Huang, T Mitsuyoshi, N Tanaka, Eiji Tanaka and Kazuo Tanne :
Modulation of hyaluronan fragmentation by interleukin-1β in synovial membrane cells,
Annals of Biomedical Engineering, Vol.38, No.4, 1618-1625, 2010.

(要約): Hyaluronan (HA) plays a crucial role in the lubricating and buffering properties of synovial fluid. The purpose of this study was to examine the effects of interleukin (IL)-1beta on HA degradation in cultured synovial membrane cells. The rabbit synovial membrane cell line HIG-82 was cultured with and without IL-1beta. The amounts of HA of varying molecular weights in the medium were analyzed using high-performance liquid chromatography, the mRNA levels of HA synthase (HAS) and hyaluronidase (HYAL) were analyzed by means of real-time PCR, and HYAL activity was analyzed by HA zymography. The amounts of HA with a molecular weight lower than 300 kDa, and between 300 and 1900 kDa, in the culture medium of HIG-82 cells were significantly higher in the presence of IL-1beta. However, the amount of HA with a molecular weight greater than 1900 kDa was significantly lower in the presence of IL-1beta. Both HAS2 and HAS3 mRNA levels were upregulated by treatment with IL-1beta. So, too, were the levels of HYAL1 and HYAL2 mRNA, which resulted in enhanced HYAL activity. However, HYAL activity was inhibited by transfection of HYAL2-siRNA. Our results suggest that IL-1beta is a crucial factor in the fragmentation of HA in inflammatory joints.
(キーワード): Animals / Cell Line / Dose-Response Relationship, Drug / Hyaluronic Acid / Interleukin-1 / Rabbits / Signal Transduction / Synovial Membrane
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-010-9927-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20099033; ● Search Scopus @ Elsevier (PMID): 20099033; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-010-9927-3

(DOI: 10.1007/s10439-010-9927-3, PubMed: 20099033) Yu-Yu Lin, Nobuaki Tanaka, Satoru Ohkuma, Yasunori Iwabuchi, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Yu-Ching Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Kotaro Tanimoto, Eiji Tanaka and Kazuo Tanne :
Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system.,
European Journal of Oral Sciences, Vol.118, No.2, 151-158, 2010.

(要約): Osteoarthritis (OA) sometimes occurs as a consequence of repeated microtrauma involved in parafunction, which may lead to microfracture in the subchondral bone. The aim of this in vitro study was to evaluate the effects of subchondral osteoblasts in loading with repeated excessive mechanical stress on the metabolism of overlying chondrocytes. A high-magnitude cyclic tensile stress of 15 kPa (30 cycles min(-1)) was applied to the cultured osteoblasts obtained from porcine mandibular condyles. The chondrocytes in alginate beads were then co-cultured with mechanically stressed or unstressed osteoblasts. Chondrocytes co-cultured with unstressed osteoblasts showed a phenotypic shift to hypertrophic chondrocytes, characterized by decreased expression of type II collagen, aggrecan, Sry-related HMG box (SOX-9), and cartilage oligomeric matrix protein (COMP) genes and increased expression of type X collagen and bone sialoprotein (BSP) genes, suggesting that the co-culture may change the chondrocyte differentiation to some extent. These changes were more distinct in chondrocytes co-cultured with excessively mechanically stressed osteoblasts. After co-culture with stressed osteoblasts, the expressions of matrix metalloproteinase (MMP)1, MMP3 and MMP13 genes were also enhanced and the synthesis of DNA, proteoglycan and collagen were significantly decreased in chondrocytes. These results demonstrate that alterations in cartilage metabolism can be induced by stressed osteoblasts, indicating a possible explanation for the onset and progression of OA.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1600-0722.2010.00710.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20487004; ● Search Scopus @ Elsevier (PMID): 20487004; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0722.2010.00710.x

(DOI: 10.1111/j.1600-0722.2010.00710.x, PubMed: 20487004) Kotaro Tanimoto, R Kitamura, Y Tanne, T Kamiya, R Kunimatsu, M Yoshioka, N Tanaka, Eiji Tanaka and Kazuo Tanne :
Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli,
Journal of Biomedical Materials Research. Part A, Vol.93, No.1, 373-380, 2010.

(要約): Hyaluronan (HA) is a component of the extracellular matrices of cartilage contributing to the structural and functional integrity. HA metabolism is regulated by both anabolic and catabolic processes; however, a great deal more of the detail has been unknown yet. The purpose of this study was to clarify the effect of excessive mechanical load on the expression and activity of hyaluronidase (HYAL) in chondrocytes with a special reference to the expressions of IL-1beta and tumor necrosis factor (TNF)-alpha. A cyclic tensile load of 22.8% cell elongation, regarded as an excessive mechanical stimulus, was applied to cultured rabbit knee articular chondrocytes. HYAL1, HYAL2, IL-1beta, and TNF-alpha mRNA levels were examined by quantitative real-time PCR analysis. The HYAL activity in culture medium was examined by HA zymography. Both HYAL1 and HYAL2 mRNA levels were upregulated significantly by the loading in cultured chondrocytes. HYAL activity was also enhanced as compared with unloaded controls. The IL-1beta mRNA level was upregulated significantly by the loading, and TNF-alpha mRNA level was slightly upregulated. HYAL1 and HYAL2 mRNA levels were upregulated significantly by IL-1beta treatment, resulting in a slight increase in HYAL activity. These results show that the expression of HYAL1 and HYAL2 in articular chondrocytes is enhanced by excessive mechanical stimuli and affected in part by induction of IL-1beta, leading to HA catabolism in articular cartilage. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2009.
(キーワード): Animals / Cells, Cultured / Chondrocytes / Gene Expression Regulation / Hyaluronic Acid / Hyaluronoglucosaminidase / Inflammation Mediators / Interleukin-1beta / Male / RNA, Messenger / Rabbits / Reverse Transcriptase Polymerase Chain Reaction / Stress, Mechanical / Tensile Strength / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jbm.a.32540
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19569218; ● Search Scopus @ Elsevier (PMID): 19569218; ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.a.32540

(DOI: 10.1002/jbm.a.32540, PubMed: 19569218) Eizo Yamano, Mutsumi Miyauchi, Hisako Furusyo, Aki Kawazoe, Atsushi Ishikado, Taketoshi Makino, Kazuo Tanne, Eiji Tanaka and Takashi Takata :
Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis.,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.90, No.8, 1236-1246, 2010.

(要約): Bovine lactoferrin (bLF) modulates the production of proinflammatory cytokines including tumor necrosis factor (TNF)-alpha, and may thus control alveolar bone destruction associated with periodontitis. In this study, the effects of bLF on mRNA expression in lipopolysaccharide (LPS)-stimulated osteoblasts (OBs) and on LPS-induced osteoclastogenesis were examined. The inhibitory effects of oral administration of liposomal-bLF (L-bLF), which improved the robustness of bLF to digestive enzymes, on alveolar bone resorption using LPS-induced periodontitis rat model are also reported. Three groups of 7-week-old male Wistar rats were treated with L-bLF (L-bLF group), bLF (bLF group), or the vehicle (control group) in drinking water (n=6 in each group). On day 7, LPS was topically applied into the gingival sulcus. Number of osteoclasts and immunoexpression of TNF-alpha were analyzed. The bLF inhibited the upregulation of TNF-alpha-mRNA- and upregulation of receptor activator of NFkappaB (RANKL)-mRNA expression and eliminated downregulation of osteoprotegerin (OPG)-mRNA expression in LPS-stimulated OBs and reduced LPS-induced osteoclastogenesis in co-culture with primary OBs and bone marrow cells. In the control group, the number of osteoclasts increased after LPS treatment. The number of osteoclasts that appeared along the alveolar bone margin was significantly reduced (P<0.01) in the L-bLF but not in the bLF group. Furthermore, L-bLF suppressed upregulation of TNF-alpha immunoexpression in periodontal tissue and TNF-alpha and interleukin (IL)-1beta-mRNA level in gingival tissue. The results of this study indicate that oral administration of L-bLF significantly reduces alveolar bone resorption induced by LPS stimulation through inhibition of TNF-alpha production and modulation of RANKL/OPG balance in OBs. It is suggested that L-bLF could be a potent therapeutic and preventive agent for attenuating alveolar bone destruction in periodontitis patients.Laboratory Investigation advance online publication, 26 April 2010; doi:10.1038/labinvest.2010.80.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/labinvest.2010.80
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20421871; ● Search Scopus @ Elsevier (PMID): 20421871; ● Search Scopus @ Elsevier (DOI): 10.1038/labinvest.2010.80

(DOI: 10.1038/labinvest.2010.80, PubMed: 20421871) Seitaro Saku, Hirotomo Kotake, RJ Vilchis Scougall, Shizue Ohashi, Masato Hotta, Shinya Horiuchi, Kenichi Hamada, Kenzo Asaoka, Eiji Tanaka and Kohji Yamamoto :
Antibacterial activity of composite resin with glass-ionomer filler particles,
Dental Materials Journal, Vol.29, No.2, 193-198, 2010.

(要約): The purpose of this study was to examine the antibacterial activity of composite resin with glass-ionomer filler particles versus that of contemporary commercial composite resins. Three composite resins were used: Beautifil II (containing S-PRG filler), Clearfil AP-X, and Filtek Z250. Resin blocks were bonded to maxillary first molars, and plaque accumulation on the resin block surface was examined after 8 hours. For the antibacterial test, the number of Streptococcus mutans in contact with the composite resin blocks after incubation for 12 hours was determined, and adherence of radiolabeled bacteria was evaluated. Less dental plaque was formed on Beautifil II resin block as compared to the other two materials. Antibacterial test revealed that there were no significant differences in the number of Streptococcus mutans among the three composite resins. However, the adherence of radiolabeled bacteria to the saliva-treated resin surface was significantly (p>0.01) lower in Beautifil II than in the other two materials. These results suggested that Beautifil II could reduce dental plaque formation and bacterial adherence, leading to prevention of secondary caries
(キーワード): Adult / Anti-Bacterial Agents / Bacterial Adhesion / Barium Compounds / Bisphenol A-Glycidyl Methacrylate / Colony Count, Microbial / Composite Resins / Dental Materials / Dental Plaque / Female / Glass / Glass Ionomer Cements / Humans / Male / Materials Testing / Methacrylates / Resin Cements / Saliva / Silicon Dioxide / Single-Blind Method / Spectrometry, X-Ray Emission / Streptococcus mutans / Surface Properties / Time Factors / Zirconium
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.2009-050
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20379030; ● Search Scopus @ Elsevier (PMID): 20379030; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2009-050

(DOI: 10.4012/dmj.2009-050, PubMed: 20379030) Yasuko Kuroda, Shingo Kuroda, Richard G. Alexander and Eiji Tanaka :
Adult Class lll Treatment Using a J-Hook Headgear to the Mandibular Arch.,
The Angle Orthodontist, Vol.80, No.2, 336-343, 2010.

(要約): ABSTRACT Objective: To evaluate the treatment effects of high-pull J-hook headgear on the lower dental arch in nongrowing Class III patients. Materials and Methods: Fourteen nongrowing Class III patients having an Angle Class III malocclusion and ANB angle of less than 1.0 degree, were treated with high-pull J-hook headgear to the lower arch. Using lateral cephalograms and plaster models obtained before treatment (T1), after active treatment (T2), and after the retention period (T3), the treatment outcome was analyzed. Results: The incisal edge of the lower central incisor moved a mean of 1.2 mm to the lingual and 1.7 mm to the occlusal between T1 and T2. The axis of the lower incisor inclined 4.0 degrees to the lingual. The lower first molar cusp moved 1.5 mm to the distal and the root apex moved 2.0 mm to the mesial. Molar angulations were tipped 9.8 degrees to the distal. The occlusal plane showed 4.5 degrees counterclockwise rotation. The mean intermolar width increased 1.5 mm on average. Comparison of the records between T2 and T3 showed minimal changes. Conclusions: Distal movement of the lower dental arch using J-hook headgear was clearly demonstrated, confirming that the application of high-pull J-hook headgear to the lower arch was effective for improvement of the Class III occlusion.
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/041609-218.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19905860; ● Search Scopus @ Elsevier (PMID): 19905860; ● Search Scopus @ Elsevier (DOI): 10.2319/041609-218.1

(DOI: 10.2319/041609-218.1, PubMed: 19905860) Takashi Kamiya, Kotaro Tanimoto, Yuki Tanne, YY Lin, Ryo Kunimatsu, Motoko Yoshioka, Nobuaki Tanaka, Eiji Tanaka and Kazuo Tanne :
Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes,
Journal of Biomedical Materials Research. Part A, Vol.92, No.2, 801-805, 2010.

(要約): Superficial zone protein (SZP) has been demonstrated to contribute to the boundary lubrication in synovial joints. This study was designed to clarify the modulation of SZP expression by mechanical stress in articular chondrocytes. Cyclic tensile strains of 7 and 21% cell elongation were applied to cultured chondrocytes obtained from porcine mandibular condylar cartilage. The mRNA levels of SZP, IL-1 beta, and TGF-beta1 were examined by a quantitative real-time PCR analysis. Protein level of SZP was examined by Western blotting. The SZP mRNA level was significantly upregulated after 12, 24, and 48 h by 7% elongation. Although SZP mRNA level was upregulated by 21% elongation after 12 h, it decreased to a lower level than the control after 48 h. The TGF-beta1 mRNA level exhibited an almost similar change to SZP. The IL-1 beta mRNA level was not changed markedly by 7% elongation. However, the IL-1 beta mRNA level was significantly increased by a 12-h application of 21% elongation. Western blot analysis revealed that the SZP expression was increased by 7% elongation, but decreased remarkably by 21% elongation. It is suggested from these findings that the SZP expression level in the chondrocytes is enhanced by optimal mechanical stimuli, but inhibited by excessive loading partly affected by TGF-beta1 and IL-1 beta, leading to the deterioration of joint lubrication. (c) 2009 Wiley Periodicals, Inc.
(キーワード): Animals / Blotting, Western / Cells, Cultured / Chondrocytes / Female / Glycoproteins / Interleukin-1beta / Physical Stimulation / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Swine / Temporomandibular Joint / Tensile Strength / Transforming Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jbm.a.32295
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19280634; ● Search Scopus @ Elsevier (PMID): 19280634; ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.a.32295

(DOI: 10.1002/jbm.a.32295, PubMed: 19280634) Maya Shirakura, Keiji Tanimoto, Hidetaka Eguchi, Mutsumi Miyauchi, Hideaki Nakamura, Keiko Hiyama, Kotaro Tanimoto, Eiji Tanaka, Takashi Takata and Kazuo Tanne :
Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.,
Biochemical and Biophysical Research Communications, Vol.393, No.4, 800-805, 2010.

(要約): Vascular endothelial growth factor (Vegf) was previously shown to be expressed specifically in the condylar cartilage of temporomandibular joint-osteoarthritis (TMJ-OA) model rats. Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression. In rat TMJs, degeneration of the condylar cartilage became prominent in proportion to the duration of overloading. Hif-1alpha expression was observed specifically in mature and hypertrophic chondrocytes, and Hif-1alpha-positivity, level of Vegf expression, and tartrate-resistant acid phosphatase (TRAP)-positive cell numbers all increased in the same manner. When ATDC5 cells induced differentiation by insulin were cultured under hypoxia, Hif-1alpha induction was observed in mature stage, but not in immature stage. Inductions of Hif-1-target genes showed a similar expression pattern. In addition, expression of Opg decreased in hypoxia, and Hif-1alpha played a role, in part, in its regulation.
(キーワード): Animals / Bone Resorption / Cartilage, Articular / Chondrocytes / Disease Models, Animal / Hypoxia-Inducible Factor 1, alpha Subunit / Male / Osteoarthritis / Osteoclasts / Rats / Rats, Wistar / Temporomandibular Joint Disorders
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2010.02.086
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20171183; ● Search Scopus @ Elsevier (PMID): 20171183; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2010.02.086

(DOI: 10.1016/j.bbrc.2010.02.086, PubMed: 20171183) R Kitamura, Kotaro Tanimoto, Y Tanne, T Kamiya, Y-C Huang, N Tanaka, Eiji Tanaka and Kazuo Tanne :
Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells,
Journal of Biomedical Materials Research. Part A, Vol.92, No.1, 87-93, 2010.

(要約): Hyaluronan (HA) has lubricating and buffering functions in joints. Mechanical load is a regulatory factor of HA metabolism in joints, and HA synthesis by synovial membrane cells is modulated by mechanical load. However, the effects of mechanical load on HA catabolism by hyaluronidase (HYAL) in synovial membrane cells remain unclear. The purpose of this study was to evaluate the effects of cyclic tensile load on the expression and activity of HYAL in synovial membrane cells. A cyclic tensile load of 22.8% cell elongation was applied to cultured rabbit synovial membrane cells for 3 to 48 h with or without cycloheximide. HYAL1 and HYAL2 mRNA levels were evaluated by means of real-time polymerase chain reaction (PCR) analysis. HYAL activity in the cell culture was analyzed by means of HA zymography with or without HYAL2-small interfering (si) RNA. Levels of both HYAL1 and HYAL2 mRNA were up-regulated significantly (p < 0.01) by the cyclic tensile load with or without cycloheximide. HYAL activity was detected in the loaded cell cultures and was suppressed substantially by HYAL2-siRNA. HYAL activity was undetectable in unloaded cell cultures. These results show that a cyclic tensile load induces the expression and activity of HYAL in synovial membrane cells, suggesting that increased HYAL by mechanical load affects HA catabolism in synovial fluid.
(キーワード): Animals / Cells, Cultured / Gene Expression Regulation, Enzymologic / Hyaluronoglucosaminidase / RNA, Messenger / RNA, Small Interfering / Rabbits / Reverse Transcriptase Polymerase Chain Reaction / Stress, Mechanical / Synovial Membrane / Transfection
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jbm.a.32345
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19165786; ● Search Scopus @ Elsevier (PMID): 19165786; ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.a.32345

(DOI: 10.1002/jbm.a.32345, PubMed: 19165786) Masahiro Hiasa, Masahiro Abe, Ayako Nakano, Asuka Oda, Hiroe Amou, Shinsuke Kido, Kyoko Takeuchi, Kumiko Kagawa, Kenichiro Yata, Toshihiro Hashimoto, Shuji Ozaki, Kenzo Asaoka, Eiji Tanaka, Keiji Moriyama and Toshio Matsumoto :
GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-{alpha} converting enzyme (TACE),
Blood, Vol.114, No.20, 4517-4526, 2009.

(要約): Monocytes give rise to macrophages, osteoclasts (OCs), and dendritic cells (DCs). M-CSF and RANK ligand induce OC differentiation from monocytes, while GM-CSF and IL-4 trigger monocytic differentiation into DCs. These two differentiation pathways occur in a mutually exclusive manner. However, regulatory mechanisms for the polarization of monocytic differentiation are still unclear. The present study was undertaken to clarify the mechanism of triggering the deflection of OC and DC differentiation from monocytes. GM-CSF and IL-4 abolished monocytic differentiation into OCs while inducing DC differentiation even in the presence of M-CSF and RANK ligand. GM-CSF and IL-4 in combination potently up-regulate TNF-alpha converting enzyme (TACE) expression and activity in monocytes, causing ectodomain shedding of the membrane-bound M-CSF receptor, resulting in the disruption of its phosphorylation by M-CSF as well as the induction of osteoclastogenesis from monocytes by M-CSF and RANK ligand. Interestingly, TACE inhibition robustly causes the resumption of the surface expression of M-CSF receptors on monocytes, which facilitates M-CSF-mediated phosphorylation of M-CSF receptors and macrophage/OC differentiation while impairing GM-CSF and IL-4-mediated DC differentiation from monocytes. These results reveal a novel proteolytic regulation of M-CSF receptor expression in monocytes to control M-CSF signaling and monocytic differentiation into macrophage/OC-lineage cells or DCs.
(キーワード): ADAM Proteins / Blotting, Western / Cell Differentiation / Dendritic Cells / Fluorescent Antibody Technique / Granulocyte-Macrophage Colony-Stimulating Factor / Humans / Interleukin-4 / Macrophages / Monocytes / Osteoclasts / RANK Ligand / Receptor, Macrophage Colony-Stimulating Factor / Reverse Transcriptase Polymerase Chain Reaction / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1182/blood-2009-04-215020
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19762488; ● Search Scopus @ Elsevier (PMID): 19762488; ● Search Scopus @ Elsevier (DOI): 10.1182/blood-2009-04-215020

(DOI: 10.1182/blood-2009-04-215020, PubMed: 19762488) Yuko Kondo, Takumi Takahashi, Yasuo Oba, Shingo Kuroda, Eiji Tanaka and Keiji Moriyama :
Blood flow distribution of repaired lip in cleft lip patients.,
The Angle Orthodontist, Vol.79, No.6, 1182-1187, 2009.

(要約): Abstract Objective: To investigate the blood flow distribution in the repaired lip of cleft patients using a laser Doppler imager and to evaluate the difference in blood flow of the scar tissue between unilateral cleft lip patients with and without cleft palate. Materials and Methods: Twenty patients with either unilateral cleft lip only (CL group, n = 8) or cleft lip and palate (CLP group, n = 12) were used as subjects. The blood flow of the upper lip was two-dimensionally visualized by a color scale alongside the corresponding photo image of the tissue surface with laser Doppler imaging. The upper lip photo image was divided into five regions: scar, white lip on the cleft side, white lip on the noncleft side, red lip on the cleft side, and red lip on the noncleft side. The average flux score (AFS), which is proportional to blood flow, was analyzed in each region. Results: The AFS for the scar region was significantly (P < .05) lower than in the other four regions. The AFS for the red lip on the cleft side was not significantly different from that for the noncleft side. The white lip revealed a significantly (P < .05) higher score on the cleft side than on the noncleft side. The AFS ratio (AFS in the scar region/AFS in the white lip region) was significantly (P < .01) lower in the CLP group than in the CL group. Conclusions: These results suggest that blood flow distribution in the repaired lip might be affected by the anatomic features of the cleft.
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/102908-549R.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19852613; ● Search Scopus @ Elsevier (PMID): 19852613; ● Search Scopus @ Elsevier (DOI): 10.2319/102908-549R.1

(DOI: 10.2319/102908-549R.1, PubMed: 19852613) JH Koolstra and Eiji Tanaka :
Tensile stress patterns predicted in the articular disc of the human temporomandibular joint,
Journal of Anatomy, Vol.215, No.4, 411-416, 2009.

(要約): The direction of the first principal stress in the articular disc of the temporomandibular joint was predicted with a biomechanical model of the human masticatory system. The results were compared with the orientation of its collagen fibers. Furthermore, the effect of an active pull of the superior lateral pterygoid muscle, which is directly attached to the articular disc, was studied. It was hypothesized that the markedly antero-posterior direction of the collagen fibers would be reflected in the direction of the tensile stresses in the disc and that active pull of the superior lateral pterygoid muscle would augment these tensions. It was found that the tensile patterns were extremely dependent on the stage of movement and on the mandibular position. They differed between the superior and inferior layers of the disc. The hypothesis could only be confirmed for the anterior and middle portions of the disc. The predicted tensile principal stresses in the posterior part of the disc alternated between antero-posterior and medio-lateral directions.
(キーワード): Bite Force / Finite Element Analysis / Humans / Models, Biological / Pterygoid Muscles / Temporomandibular Joint / Temporomandibular Joint Disc / Tensile Strength
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1469-7580.2009.01127.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19627392; ● Search Scopus @ Elsevier (PMID): 19627392; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7580.2009.01127.x

(DOI: 10.1111/j.1469-7580.2009.01127.x, PubMed: 19627392) Nobuhiko Kawai, Sano Ryota, Korfage A M J, Nakamura Saika, Eiji Tanaka, Wessel van Tim, Langenbach E J G and Kazuo Tanne :
Functional characteristics of the rat jaw muscles: daily muscle activity and fiber type composition,
Journal of Anatomy, Vol.215, No.6, 656-662, 2009.

(要約): Skeletal muscles have a heterogeneous fiber type composition, which reflects their functional demand. The daily muscle use and the percentage of slow-type fibers have been shown to be positively correlated in skeletal muscles of larger animals but for smaller animals there is no information. The examination of this relationship in adult rats was the purpose of this study. We hypothesized a positive relationship between the percentage of fatigue-resistant fibers in each muscle and its total duration of use per day. Fourteen Wistar strain male rats (410-450 g) were used. A radio-telemetric device was implanted to record muscle activity continuously from the superficial masseter, deep masseter, anterior belly of digastric and anterior temporalis muscles. The degree of daily muscle use was quantified by the total duration of muscle activity per day (duty time) exceeding specified levels of the peak activity (2, 5, 20 and 50%). The fiber type composition of the muscles was examined by the myosin heavy chain content of the fibers by means of immunohistochemical staining. At lower activity levels (exceeding 2 and 5% of the peak activity), the duty time of the anterior belly of digastric muscle was significantly (P < 0.01) longer than those of the other muscles. The anterior belly of digastric muscle also contained the highest percentage of slow-type fibers (type I fiber and hybrid fiber co-expressing myosin heavy chain I + IIA) (ca. 11%; P < 0.05). By regression analysis for all four muscles, an inter-muscular comparison showed a positive relationship between the duty time (exceeding 50% of the peak activity) and the percentage of type IIX fibers (P < 0.05), which demonstrate intermediate physiological properties relative to type IIA and IIB fibers. For the jaw muscles of adult male rats, the variations of fiber type composition and muscle use suggest that the muscle containing the largest amounts of slow-type fibers (the anterior belly of digastric muscle) is mainly involved in low-amplitude activities and that the amount of type IIX fibers is positively related to the generation of large muscle forces, validating our hypothesis.
(キーワード): Animals / Electromyography / Male / Masticatory Muscles / Muscle Fibers, Fast-Twitch / Muscle Fibers, Skeletal / Muscle Fibers, Slow-Twitch / Myosin Heavy Chains / Rats / Rats, Wistar / Telemetry
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1469-7580.2009.01152.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19811563; ● Search Scopus @ Elsevier (PMID): 19811563; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7580.2009.01152.x

(DOI: 10.1111/j.1469-7580.2009.01152.x, PubMed: 19811563) 冨田優子, 堀内信也, 高橋巧, 神野恵, 黒田晋吾, 田中栄二 :
過去10年間に徳島大学病院矯正歯科を受診した顎顔面骨骨折患者の実態調査,
中·四国矯正歯科学会雑誌, Vol.21, No.1, 71-75, 2009年. 石本恭子, 黒田晋吾, 高橋巧, 渡邉佳一郎, 田中栄二 :
ミニスクリュー固定を用いて上顎歯列の遠心移動を行ったアングルⅡ級2類過蓋咬合症例,
中·四国矯正歯科学会雑誌, Vol.21, No.1, 31-39, 2009年. 川上恵実, 堀内信也, 松田りえ, 泰江章博, 黒田晋吾, 田中栄二 :
PLLAスクリュー固定による下顎枝矢状分割術を施行した骨格性下顎前突症の一症例-長期観察例-,
中·四国矯正歯科学会雑誌, Vol.21, No.1, 25-30, 2009年. Yuki Nakatani, Kotaro Tanimoto, Nobuaki Tanaka, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Eiji Tanaka and Kazuo Tanne :
Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells,
Archives of Oral Biology, Vol.54, No.8, 757-763, 2009.

(要約): It is well known that low-molecular weight hyaluronan (HA) is detected in human periodontal tissue under inflammatory conditions. HA oligosaccharide (HAoligo) has been demonstrated to induce matrix metalloproteinase (MMP)-1 expression in dendritic cells and chondrocytes, however, the bioactivities of HAoligo in periodontal ligament (PDL) cells remain unclear. In this study, we investigated the effect of HAoligo on MMP-1 expression in human PDL (HPDL) cells and the mechanisms in terms of the signal transmission. HAoligo was generated and purified from commercial human umbilical cord HA. HPDL cells were isolated from healthy ligaments, and cultured with HAoligo for 0-24h. The expression of MMP-1, tissue inhibitor of MMPs (TIMP)-1 and TIMP-2 was analyzed by real-time PCR and Western blot analyses. Effects of specific inhibitors of p38 mitogen-activated protein kinase (MAPK) activity, MAPK kinase activity and NFkB activity on HAoligo-induced MMP-1 expression in HPDL cells were also investigated by real-time PCR and Western blot analyses. HAoligo remarkably enhanced MMP-1 expression in both mRNA and protein levels, but no effect was shown on the expression of TIMP-1 and TIMP-2 mRNAs. Inhibition of p38MAPK activity decreased the MMP-1 expression. Neither inhibition of NFkB nor MAPKK activity affected the MMP-1 expression. It was suggested that HAoligo induces MMP-1 expression in HPDL cells, and p38MAPK plays a crucial role in signal transduction for MMP-1 inducted by HAoligo
(キーワード): Anti-Inflammatory Agents / Cells, Cultured / Dose-Response Relationship, Drug / Enzyme Inhibitors / フラボノイド (flavonoids) / Humans / Hyaluronic Acid / Imidazoles / Matrix Metalloproteinase 1 / Mitogen-Activated Protein Kinase Kinases / NF-kappa B / Oligosaccharides / Periodontal Ligament / Pyridines / Sesquiterpenes / シグナル伝達 (signal transduction) / Tissue Inhibitor of Metalloproteinase-1 / Tissue Inhibitor of Metalloproteinase-2 / p38 Mitogen-Activated Protein Kinases
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2009.05.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19523610; ● Search Scopus @ Elsevier (PMID): 19523610; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2009.05.005

(DOI: 10.1016/j.archoralbio.2009.05.005, PubMed: 19523610) Y Ohnuki, Nobuhiko Kawai, Eiji Tanaka, Kazuo Tanne, GEJ Langenbach and Y Saeki :
Effects of increased occlusal vertical dimension on daily activity and myosin heavy chain composition in rat jaw muscle,
Archives of Oral Biology, Vol.54, No.8, 783-789, 2009.

(要約): Mammalian skeletal muscles change their contractile-protein phenotype in response to mechanical loading and/or chronic electrical stimulation, implying that the phenotypic changes in masticatory muscles might result from new masticatory-loading conditions. To analyze the effects of increased occlusal vertical dimension (OVD) on daily activities and fibre-type compositions in jaw muscles, we measured the total duration of daily activity (duty time) and the myosin heavy chain (MyHC) compositions in the masseter and digastric muscles of freely moving control and bite-opened rats. In the control state, the duty time of the digastric muscle was higher than that of the masseter muscle at activity levels exceeding 5 and 20% of the day's peak activity. The opposite was true at activity levels exceeding 50 and 80% of the day's peak activity. The MyHCs consisted of a mixture of fast and slow types in the digastric muscle. The masseter consisted of mostly fast-type MyHC. The increment of OVD increased not only the duty time at activity levels exceeding 5, 20, 50 and 80% of the day' peak activity in both muscles but also the proportion of MyHC IIa in the masseter muscle and MyHC I in the digastric muscle at the expense of that of MyHC IIb. These results suggest that the increment of OVD changes masseter and digastric muscles towards slower phenotypes by an increase in their daily activities.
(キーワード): Animals / Electrodes, Implanted / Electromyography / Electrophoresis, Polyacrylamide Gel / Masseter Muscle / Muscle Contraction / Muscle Fibers, Fast-Twitch / Muscle Fibers, Slow-Twitch / Myosin Heavy Chains / Neck Muscles / Open Bite / Phenotype / Rats / Vertical Dimension
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2009.05.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19524215; ● Search Scopus @ Elsevier (PMID): 19524215; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2009.05.008

(DOI: 10.1016/j.archoralbio.2009.05.008, PubMed: 19524215) Kei Jinno, Takumi Takahashi, K Tsuchida, Eiji Tanaka and Keiji Moriyama :
Acceleration of palatal wound healing in Smad3-deficient mice,
Journal of Dental Research, Vol.88, No.8, 757-761, 2009.

(要約): Wound healing is a well-orchestrated complex process leading to the repair of injured tissues. It is suggested that transforming growth factor (TGF)-beta/Smad3 signaling is involved in wound healing. The purpose of this study was to investigate the role of TGF-beta/Smad3 signaling in palatal wound healing in Smad3-deficient (Smad3(-/-)) mice. Histological examination showed that wound closure was accelerated by the proliferation of epithelium and dermal cells in Smad3(-/-) mice compared with wild-type (WT) mice. Macrophage/monocyte infiltration at wounded regions in Smad3(-/-) mice was decreased in parallel with the diminished production of TGF-beta1, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1alpha compared with WT mice. Fibrocytes, expressing hematopoietic surface marker and fibroblast products, were recruited and produced alpha-smooth-muscle actin in WT mice, but were not observed in Smad3(-/-) mice. These results suggest that TGF-beta/Smad3 signaling may play an important role in the regulation of palatal wound healing.
(キーワード): Actins / Animals / Antigens, Surface / Cell Proliferation / Chemokine CCL2 / Chemokine CCL3 / Chemotaxis / Epithelium / Fibroblasts / Hematopoiesis / Langerhans Cells / Macrophages / Mice / Mice, Knockout / Monocytes / Mouth Mucosa / Palate / Signal Transduction / Smad3 Protein / Transforming Growth Factor beta / Wound Healing
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0022034509341798
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19734465; ● CiNii @ 国立情報学研究所 (CRID): 1571980076127100800; ● Search Scopus @ Elsevier (PMID): 19734465; ● Search Scopus @ Elsevier (DOI): 10.1177/0022034509341798

(DOI: 10.1177/0022034509341798, PubMed: 19734465, CiNii: 1571980076127100800) C Nishio, K Tanimoto, M Hirose, Shinya Horiuchi, Shingo Kuroda, Kazuo Tanne and Eiji Tanaka :
Stress analysis in the mandibular condyle during prolonged clenching: a theoretical approach with the finite element method.,
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, Vol.223, No.6, 739-748, 2009.

(要約): Parafunctional habits, such as bruxism and prolonged clenching, have been associated with functional overloading in the temporomandibular joint (TMJ), which may result in internal derangement and osteoarthrosis of the TMJ. In this study, the distributions of stress on the mandibular condylar surface during prolonged clenching were examined with TMJ mathematical models. Finite element models were developed on the basis of magnetic resonance images from two subjects with or without anterior disc displacement of the TMJ. Masticatory muscle forces were used as a loading condition for stress analysis during a 10 min clenching. In the asymptomatic model, the stress values in the anterior area (0.100 MPa) and lateral area (0.074 MPa) were relatively high among the five areas at 10 min. In the middle and posterior areas, stress relaxation occurred during the first 2 min. In contrast, the stress value in the lateral area was markedly lower (0.020 MPa) than in other areas in the symptomatic model at 10 min. The largest stress (0.050 MPa) was located in the posterior area. All except the anterior area revealed an increase in stress during the first 2 min. The present result indicates that the displacement of the disc could affect the stress distribution on the condylar articular surface during prolonged clenching, especially in the posterior area, probably leading to the cartilage breakdown on the condylar articular surface.
(キーワード): Bite Force / Bruxism / Computer Simulation / Dental Stress Analysis / Elastic Modulus / Finite Element Analysis / Humans / Mandibular Condyle / Models, Biological / Stress, Mechanical
(出版サイトへのリンク): ● Publication site (DOI): 10.1243/09544119JEIM485
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19743639; ● Search Scopus @ Elsevier (PMID): 19743639; ● Search Scopus @ Elsevier (DOI): 10.1243/09544119JEIM485

(DOI: 10.1243/09544119JEIM485, PubMed: 19743639) Shinya Horiuchi, Kazuyuki Kaneko, H Mori, Emi Kawakami, T Tsukahara, K Yamamoto, Kenichi Hamada, Kenzo Asaoka and Eiji Tanaka :
Enamel bonding of self-etching and phosphoric acid-etching orthodontic adhesives in simulated clinical conditions: Debonding force and enamel surface,
Dental Materials Journal, Vol.28, No.4, 419-425, 2009.

(要約): This study aimed to evaluate the effectiveness of self-etching and phosphoric acid-etching orthodontic adhesives for enamel bonding in simulated clinical conditions. By using two self-etching (Transbond Plus, TP; Beauty Ortho Bond, BB) and two acid-etching (Transbond XT, TX; Superbond Orthomite, SB) adhesives, orthodontic brackets were bonded on human premolars (n=10 for each adhesive). Ten teeth without bracket bonding, i.e., intact enamel surfaces, were used as control for SEM observation. After 7-day storage in lactic acid solution, bracket debonding force by means of debonding pliers, adhesive remnant index (ARI), and enamel surface morphology were examined. All the tested adhesives exhibited sufficient bond strength for clinical use. The ARI scores were almost the same among the four adhesives. In terms of SEM observation, the enamel surfaces in the control and TP groups showed a slight change after immersion in lactic acid solution, while the BB group showed less change on the enamel surface compared with the TP group. Meanwhile, the two acid-etching adhesives caused considerable demineralization. Taken together, these findings indicated that the action of self-etching systems was evidently more conservative.
(キーワード): Bicuspid / Dental Bonding / Dental Debonding / Dental Enamel / Dental Etching / Dental Stress Analysis / Humans / Materials Testing / Orthodontic Brackets / Resin Cements / Surface Properties
(出版サイトへのリンク): ● Publication site (DOI): 10.4012/dmj.28.419
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19721278; ● Search Scopus @ Elsevier (PMID): 19721278; ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.28.419

(DOI: 10.4012/dmj.28.419, PubMed: 19721278) YY Lin, Nobuaki Tanaka, Satoru Ohkuma, Takashi Kamiya, Ryo Kunimatsu, Y-C Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Yuki Tanne, Kotaro Tanimoto, Eiji Tanaka and Kazuo Tanne :
The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading,
Annals of Biomedical Engineering, Vol.37, No.7, 1358-1367, 2009.

(要約): Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a degenerative disease caused by excessive external loading. Recently, it was reported that the damage in the mineralized subchondral bone caused by traumatic impact-loading is responsible for the initiation and progression of cartilage degeneration. Thus far, we have hypothesized that cytokines released from damaged subchondral bone from impact-loading affect the cartilage catabolism under pathological conditions. An impactor of 200 gw was dropped onto the top of a porcine mandibular condyle. After organ culture for 2 days, we investigated the association between the subchondral bone and cartilage using histological and biochemical experiments. The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone. We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone. The mRNA expressions of type II collagen, aggrecan, and type X collagen in chondrocytes were decreased significantly by the co-culture with osteoblasts pre-treated by IL-1beta, -6, and TNF-alpha. Among them, osteoblasts pre-treated by IL-1beta affected chondrocytes most strongly. It was also shown that IL-1beta-treated osteoblasts enhanced the MMP-1 mRNA level most markedly in chondrocytes among the four cytokines. These results suggest that the TMJ subjected to impact-loading can increase directly IL-1beta synthesis in the subchondral region, subsequently altering the metabolism of adjacent cartilage and may eventually resulting in the onset and progression of TMJ-OA.
(キーワード): Animals / Cartilage / Cytokines / Interleukin-1beta / Mandible / Organ Culture Techniques / Swine / Weight-Bearing / Wounds, Nonpenetrating
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-009-9696-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19381811; ● Search Scopus @ Elsevier (PMID): 19381811; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-009-9696-z

(DOI: 10.1007/s10439-009-9696-z, PubMed: 19381811) Shinya Horiuchi, Kenzo Asaoka and Eiji Tanaka :
Development of a novel cement by conversion of hopeite in set zinc phosphate cement into biocompatible apatite,
Bio-Medical Materials and Engineering, Vol.19, No.2, 121-131, 2009.

(要約): Synthetic bone cement that has zinc oxide core particles covered with hydroxyapatite (HAP) was developed; that is, the conversion of hopeite, the traditional zinc phosphate cement, into HAP was attempted. Here, hopeite is the final product of the reaction between powders and trituration liquid of the traditional zinc phosphate cement. This cement may have many advantages not only in terms of biological functions but also the setting process of the traditional cement and the mechanical properties of the developed compact if the hopeite can be converted into calcium phosphate (CP). In this study, calcium nitrate solutions of various concentrations were used for the conversion of hopeite crystals into CP. The products after the solution treatment were analyzed by X-ray diffractometry (XRD), Fourier transform infrared spectrometry (FTIR), and scanning electron microscope (SEM) observation. These results indicated that the converted scholzite crystals could be partially detected. Several types of set zinc phosphate cement with different P/L ratios were arranged. The surface products of the set cement after the solution treatment were analyzed by XRD. However, the crystal phase such as hopeite was not detected except for zinc oxide. The set cement, which was treated with the calcium nitrate solution, was immersed in simulated body fluid (SBF). HAP-like crystals on the set cement could be detected for the specimens immersed for 4 weeks. These findings suggested that the binding phase in the set cement could be converted into HAP by immersion in SBF.
(キーワード): Absorption / Adhesiveness / Biocompatible Materials / Body Fluids / Bone Cements / Crystallization / Durapatite / Hardness / Materials Testing / Particle Size / Phosphates / Porosity / Surface Properties / Zinc Compounds
(出版サイトへのリンク): ● Publication site (DOI): 10.3233/BME-2009-0571
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19581705; ● Search Scopus @ Elsevier (PMID): 19581705; ● Search Scopus @ Elsevier (DOI): 10.3233/BME-2009-0571

(DOI: 10.3233/BME-2009-0571, PubMed: 19581705) 川上清一, 川上映子, 菅野貴浩, 藤岡真左子, 田中栄二 :
口内法LeFort Ⅱ型骨切り術により中顔面の陥凹を改善させた骨格性下顎前突症例,
四国歯学会雑誌, Vol.22, No.1, 123-128, 2009年. Shingo Kuroda, Kotaro Tanimoto, Takashi Izawa, Shinji Fujihara, J H. Koolstra and Eiji Tanaka :
Biomechanical and biochemical characteristics of the mandibular condylar cartilage.,
Osteoarthritis and Cartilage, Vol.17, No.11, 1408-1415, 2009.

(要約): The human masticatory system consists of a mandible which is able to move with respect to the skull at its bilateral temporomandibular joint (TMJ) through contractions of the masticatory muscles. Like other synovial joints, the TMJ is loaded mechanically during function. The articular surface of the mandibular condyle is covered with cartilage that is composed mainly of collagen fibers and proteoglycans. This construction results in a viscoelastic response to loading and enables the cartilage to play an important role as a stress absorber during function. To understand its mechanical functions properly, and to assess its limitations, detailed information about the viscoelastic behavior of the mandibular condylar cartilage is required. The purpose of this paper is to review the fundamental concepts of the biomechanical behavior of the mandibular condylar cartilage. This review consists of four parts. Part 1 is a brief introduction of the structure and function of the mandibular condylar cartilage. In Part 2, the biochemical composition of the mandibular condylar cartilage is summarized. Part 3 explores the biomechanical properties of the mandibular condylar cartilage. Finally, Part 4 relates this behavior to the breakdown mechanism of the mandibular condylar cartilage which is associated with the progression of osteoarthritis in the TMJ.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.joca.2009.04.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19477310; ● Search Scopus @ Elsevier (PMID): 19477310; ● Search Scopus @ Elsevier (DOI): 10.1016/j.joca.2009.04.025

(DOI: 10.1016/j.joca.2009.04.025, PubMed: 19477310) Yukiko Kitase, Masahiko Yokozeki, Shinji Fujihara, Takashi Izawa, Shingo Kuroda, Kotaro Tanimoto, Keiji Moriyama and Eiji Tanaka :
Analysis of gene expression profiles in human periodontal ligament cells under hypoxia: the protective effect of CC chemokine ligand 2 to oxygen shortage.,
Archives of Oral Biology, Vol.54, No.7, 618-624, 2009.

(要約): Periodontal ligament (PDL) cells appear to play important functional roles in response to mechanical stress. We hypothesized that hypoxia caused by a deformation of blood vessels and the following ischaemia may play a crucial role in differential gene expression in PDL cells affected by mechanical stress. Gene induction in cultured human PDL cells by hypoxia was analyzed using cDNA array, followed by RT-PCR analysis. Eleven hypoxia-responsive genes were found differentially expressed under low-oxygen conditions in PDL cells. Among them, CCR2, CC chemokine ligand 2 (CCL2) receptor was studied in more detail since little information is available on the role of chemokines in adaptive responses of PDL cells under hypoxia. Here we investigate whether CCR2 mediates the signalling to maintain the homeostasis of PDL cells. We found that cell death of PDL cells was induced under hypoxia with down-regulation of CCL2 mRNA expression. However, the exogenous CCL2 prevented PDL cell death under oxygen shortage with the increment of cellular inhibitor of apoptosis (cIAP) mRNA expression. The present study demonstrated substantial effects of hypoxia on gene expression of CCL2 and CCR2 in PDL cells, indicating that mechanical loading accompanied with mild hypoxia allows PDL cells to elicit adaptive responses with up-regulation of CCR2.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2009.03.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19406381; ● Search Scopus @ Elsevier (PMID): 19406381; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2009.03.010

(DOI: 10.1016/j.archoralbio.2009.03.010, PubMed: 19406381) Nishio Clarice, Mendes de Moraes Alvaro, Almeida Antonio de Oliveira Marco, Eiji Tanaka, Tanne Kazuo and Eliasf Nelson Carlos :
Evaluation of esthetic brackets' resistance to torsional forces from the archwire,
American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.135, No.1, 42-48, 2009.

(要約): The aim of this study was to evaluate the resistance to deformation or fracture of esthetic brackets produced by archwire torsion. Six types of maxillary right central incisor brackets were analyzed: traditional ceramic brackets (cer); ceramic brackets reinforced with a stainless steel slot (cer/ss); ceramic brackets reinforced with a gold slot (cer/gold); traditional polycarbonate brackets (poly); polycarbonate brackets reinforced with a stainless steel slot (poly/ss); and polycarbonate brackets reinforced with ceramic fillers and a stainless steel slot (poly/cer/ss). Stainless steel wire segments were used, and the testing instrument (Emic DL 10000, São José do Rio Preto, PR, Brazil) was moved at a rate of 1 inch per minute to generate the wire torsion. The brackets showed deformation or fracture resistance values (gf x mm) in decreasing order as follows: cer/ss (3528.1 +/- 516.6), cer/gold (2858.7 +/- 611.6), cer (2424.0 +/- 352.1), poly/cer/ss (2279.5 +/- 174.5), poly/ss (2142.0 +/- 275.7), and poly (1463.6 +/- 193.3). The cer/ss ceramic brackets showed the greatest statistically significant (P <0.01) values of resistance to fracture, and the poly brackets had the lowest statistically significant (P <0.01) values of resistance to deformation. The cer brackets showed no significant differences (P >0.01) from the cer/gold, the poly/cer/ss, and the poly/ss brackets. This suggested that the stainless steel slot might enhance resistance to deformation or fracture, although gold slots and ceramic fillers are ineffective for reinforcing esthetic brackets.
(キーワード): セラミックス (ceramics) / Dental Alloys / Dental Materials / Equipment Failure / Esthetics, Dental / Gold Alloys / Humans / Materials Testing / Orthodontic Appliance Design / Orthodontic Brackets / Orthodontic Wires / Polycarboxylate Cement / Stainless Steel / Stress, Mechanical / 界面特性 (surface properties) / Torsion, Mechanical
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajodo.2007.04.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19121499; ● Search Scopus @ Elsevier (PMID): 19121499; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajodo.2007.04.036

(DOI: 10.1016/j.ajodo.2007.04.036, PubMed: 19121499) Eiji Tanaka, R Sano, Nobuhiko Kawai, J M A Korfage, S Nakamura, Takashi Izawa, G J E Langenbach and Kazuo Tanne :
Regional differences in fiber characteristics in the rat temporalis muscle,
Journal of Anatomy, Vol.213, No.6, 743-748, 2008.

(要約): The behavioral differences in muscle use are related to the fiber type composition of the muscles among other variables. The aim of this study was to examine the degree of heterogeneity in the fiber type composition in the rat temporalis muscle. The temporalis muscle was taken from 10-week-old Wistar strain male rats (n = 5). Fiber types were classified by immunohistochemical staining according to their myosin heavy chain content. The anterior temporalis revealed an obvious regional difference of the fiber type distribution, whereas the posterior temporalis was homogeneous. The deep anterior temporalis showed a predominant proportion of type IIA fibers and was the only muscle portion displaying slow type fibers (< 10%). The other two muscle portions, the superficial anterior and posterior temporalis, did not differ significantly from each other and contained mainly type IIB fibers. Moreover, the deep anterior temporalis was the only muscle portion showing slow type fibers (< 10%). In the deep portion, type IIX fibers revealed the largest cross-sectional area (1943.1 +/- 613.7 microm(2)), which was significantly (P < 0.01) larger than those of type IIA and I + IIA fibers. The cross-sectional area of type IIB fibers was the largest in the remaining two muscle portions and was significantly (P < 0.01) larger than that of type IIX fibers. In conclusion, temporalis muscle in rats showed an obvious heterogeneity of fiber type composition and fiber cross-sectional area, which suggests multiple functions of this muscle.
(キーワード): Animals / Biological Markers / Immunohistochemistry / Male / Muscle Fibers, Fast-Twitch / Muscle Fibers, Skeletal / Muscle Fibers, Slow-Twitch / Myosin Heavy Chains / Rats / Rats, Wistar / Temporal Muscle
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1469-7580.2008.00990.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19094190; ● Search Scopus @ Elsevier (PMID): 19094190; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7580.2008.00990.x

(DOI: 10.1111/j.1469-7580.2008.00990.x, PubMed: 19094190) Eiji Tanaka, A Kawazoe, S Nakamura, G Ito, N Hirose, Y Tanne, N Kawai, K Tanimoto and K Tanne :
An adolescent patient with multiple impacted teeth,
The Angle Orthodontist, Vol.78, No.6, 1110-1118, 2008.

(要約): Multiple impacted permanent teeth is uncommon and rarely reported in the literature. This article reports the treatment of an adolescent patient with multiple impacted teeth without systemic disease. A 9-year 2-month-old boy complained of a delay of eruption of the first molars. All first molars were unerupted, and the left deciduous second molar was a submerged tooth. The panoramic radiograph showed all permanent teeth except the incisors were unerupted and, especially for the first molars, spontaneous eruption was not expected. His medical history was uneventful. A lingual arch appliance and a segmental arch were placed on the mandibular and maxillary dentitions, respectively, to guide eruption of the impacted first molars. After traction of the first molars, eruption of the impacted lower premolars was induced. Furthermore, at 15 years the impacted mandibular second molars were also positioned properly by use of the lingual arch with auxiliary wires. After achieving traction of the impacted teeth, tooth alignment was initiated using multibracket appliances after the bilateral extraction of the second premolars. After 22 months of treatment with multibracket appliances, an acceptable occlusion was achieved with a Class I molar relationship. After 2 years of retention an acceptable occlusion was maintained without any relapse in the occlusion. Since a delay in the treatment of impacted teeth may induce secondary problems such as root dilacerations and ankylosis, it is highly recommended to perform early treatment of multiple impacted teeth during adolescence.
(キーワード): Adolescent / Bicuspid / Child / Cuspid / Humans / Male / Malocclusion, Angle Class I / Molar / Radiography, Panoramic / Tooth Movement / Tooth, Impacted / Tooth, Unerupted / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/121007-581.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18947292; ● Search Scopus @ Elsevier (PMID): 18947292; ● Search Scopus @ Elsevier (DOI): 10.2319/121007-581.1

(DOI: 10.2319/121007-581.1, PubMed: 18947292) Eiji Tanaka and JH Koolstra :
Biomechanics of the temporomandibular joint,
Journal of Dental Research, Vol.87, No.11, 989-991, 2008.

(キーワード): Biomechanics / Dental Stress Analysis / Finite Element Analysis / Humans / Models, Biological / Range of Motion, Articular / Temporomandibular Joint
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/154405910808701101
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18946004; ● Search Scopus @ Elsevier (PMID): 18946004; ● Search Scopus @ Elsevier (DOI): 10.1177/154405910808701101

(DOI: 10.1177/154405910808701101, PubMed: 18946004) T Inubushi, Eiji Tanaka, EB Rego, M Kitagawa, A Kawazoe, A Ohta, H Okada, JH Koolstra, M Miyauchi, T Takata and K. Tanne :
Effects of Ultrasound on the Proliferation and Differentiation of Cementoblast Lineage Cells,
Journal of Periodontology, Vol.79, No.10, 1984-1990, 2008.

(要約): Background: The purpose of this study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) stimulation on the proliferation and differentiation of cementoblast lineage cells. Methods: An immortalized human periodontal ligament cell line (HPL) showing immature cementoblastic differentiation was used. Cultured HPL cells were subjected to LIPUS exposure (frequency = 1 MHz; pulsed 1:4; intensity = 30 mW/cm(2)) or sham exposure for 15 minutes per day. Expression levels of alkaline phosphatase (ALP), type I collagen (Col-I), runt-related gene 2 (Runx2), bone sialoprotein (BSP), osteocalcin (OCN), and osteopontin (OPN) mRNA were analyzed with real-time polymerase chain reaction analysis. Furthermore, ALP activity, collagen synthesis, and protein level of Runx2 were examined after 6 days of LIPUS exposure. Results: mRNA and protein levels of ALP, Col-I, and Runx2 were significantly increased by LIPUS exposure compared to controls, whereas BSP, OCN, and OPN mRNA expression could not be detected in HPL cells, irrespective of LIPUS exposure. Conclusion: LIPUS enhanced ALP activity, collagen synthesis, and Runx2 expression of HPL cells, which provides important insight into the promotion of early cementoblastic differentiation of immature cementoblasts.
(キーワード): Alkaline Phosphatase / Biological Markers / Blotting, Western / Cell Differentiation / Cell Line / Cell Lineage / Cell Proliferation / Cells, Cultured / Collagen / Collagen Type I / Core Binding Factor Alpha 1 Subunit / Dental Cementum / Humans / Integrin-Binding Sialoprotein / Osteocalcin / Osteopontin / Periodontal Ligament / Polymerase Chain Reaction / RNA / Sialoglycoproteins / Ultrasonics
(出版サイトへのリンク): ● Publication site (DOI): 10.1902/jop.2008.080081
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18834255; ● Search Scopus @ Elsevier (PMID): 18834255; ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2008.080081

(DOI: 10.1902/jop.2008.080081, PubMed: 18834255) 白倉麻耶, 山野栄三, 花岡宏一, 田中栄二, 丹根一夫 :
鎖骨頭蓋異骨症を伴う一卵性双生児における口腔顎顔面形態,
中·四国矯正歯科学会雑誌, Vol.20, No.1, 61-70, 2008年. 藤原慎視, 堀内信也, 井澤俊, 辻けい子, 大庭康雄, 森山啓司, 田中栄二 :
エナメル質形成不全を伴う空隙歯列症例の一治験例,
中·四国矯正歯科学会雑誌, Vol.20, No.1, 55-60, 2008年. 井澤俊, 堀内信也, 辻けい子, 藤原慎視, 大庭康雄, 田中栄二, 森山啓司 :
下顎枝垂直骨切り術と下顎枝矢状分割術を併用した外科的矯正治療後に下顎頭のリモデリングを認めた一症例,
日本顎関節学会雑誌, Vol.20, No.2, 134-138, 2008年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11246/gakukansetsu1989.20.134
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204419815552; ● Search Scopus @ Elsevier (DOI): 10.11246/gakukansetsu1989.20.134

(DOI: 10.11246/gakukansetsu1989.20.134, CiNii: 1390001204419815552) Eiji Tanaka, N Hirose, JH Koolstra, TMGJ Eijden van, R Fujita, M Tanaka, Y Iwabuchi and Kazuo Tanne :
Modeling of the effect of friction in the temporomandibular joint on displacement of its disc during prolonged clenching,
Journal of Oral and Maxillofacial Surgery, Vol.66, No.3, 462-468, 2008.

(要約): The effect of the frictional coefficient in the temporomandibular joint on the disc during prolonged clenching was examined. For this purpose, a finite element model of the temporomandibular joint based on magnetic resonance images from a volunteer subject was used. Muscle forces applied for clenching were used as a loading condition for stress analysis during 10 minutes. With respect to the frictional coefficient between articular surfaces, 3 different values ranging from micro = 0.001 to micro = 0.1 were established. At the onset of clenching, large stresses were found in the central and lateral part of the intermediate zone in the disc, and its stress distribution was not markedly changed during 10 minutes of clenching. In the retrodiscal tissue, stress relaxation occurred during the first 2 minutes of clenching. When the frictional coefficient between articular surfaces increased, the anterior, lateral, and central points in the disc moved further forward. At the end of 10 minutes of clenching, the disc showed a more anterior position as the frictional coefficient increased. This result indicates that increase of the frictional coefficient between the articular surfaces may be a major cause for the onset of the disc displacement.
(キーワード): Adult / Biomechanics / Bruxism / Dental Stress Analysis / Dislocations / Female / Finite Element Analysis / Humans / Masticatory Muscles / Temporomandibular Joint / Temporomandibular Joint Disc / Temporomandibular Joint Disorders / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.joms.2007.06.640
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18280378; ● Search Scopus @ Elsevier (PMID): 18280378; ● Search Scopus @ Elsevier (DOI): 10.1016/j.joms.2007.06.640

(DOI: 10.1016/j.joms.2007.06.640, PubMed: 18280378) N Kawai, Eiji Tanaka, GE Langenbach, T Wessel van, R Sano, TM Eijden van and K Tanne :
Jaw-muscle activity changes after the induction of osteoarthrosis in the temporomandibular joint by mechanical loading,
Journal of Orofacial Pain, Vol.22, No.2, 153-162, 2008.

(要約): AIMS: To examine the effect of mechanical loading on the induction of temporomandibular joint osteoarthrosis (TMJ OA). METHODS: Mechanical stress was applied to the rat TMJ by forced jaw opening of 3 hours a day for 5 days. The electromyographic (EMG) activity of the masseter and digastric muscles was continuously monitored by radio-telemetry. It was characterized by the total time each muscle was active (duty time), the number of bursts, and the average burst length. For histologic analysis, rats were sacrificed before, immediately after, and 3 weeks after the period of forced jaw opening. RESULTS: The condylar cartilage revealed OA-like lesions with a decrease in the number of chondrocytes immediately after forced jaw opening. Three weeks later, the OA-like lesions were repaired to some extent. After the forced jaw opening, the duty time of the masseter increased, whereas the duty time of the digastric decreased significantly (P < .01) at the 5% activity level. Three weeks later, the masseter duty time had decreased and the digastric duty time had slightly increased, returning to the levels observed before forced jaw opening. CONCLUSION: These results suggest that mechanical overloading of the TMJ induced OA-like lesions with a simultaneous influence on jaw muscle activity, especially at the low activity level. This might imply that muscle activity adapted to reduce the effects of (forced) joint overloading.
(キーワード): Animals / Cartilage, Articular / Dental Stress Analysis / Electromyography / Male / Masseter Muscle / Neck Muscles / Osteoarthritis / Rats / Rats, Wistar / Stress, Mechanical / Telemetry / Temporomandibular Joint Disorders
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18548845; ● Search Scopus @ Elsevier (PMID): 18548845

(PubMed: 18548845) M Ueki, N Tanaka, K Tanimoto, C Nishio, K Honda, YY Lin, Y Tanne, S Ohkuma, T Kamiya, Eiji Tanaka and Kazuo Tanne :
The effect of mechanical loading on the metabolism of growth plate chondrocytes,
Annals of Biomedical Engineering, Vol.36, No.5, 793-800, 2008.

(要約): It is well known that mechanical loading influences the endochondral bone formation essential for the growth and development of longitudinal bones. The question was, however, asked whether the effect of mechanical loading on the chondrocyte metabolism is dependent on the loading frequency. This study was aimed at evaluating the effect of tensile loadings with various frequencies on the proliferation of growth plate chondrocytes and extracellular matrix synthesis. The chondrocytes obtained from rib growth plate cartilage of 4-week-old male Wistar strain rats were cultured by day 4 and day 11 and used as proliferating and matrix-forming chondrocytes, respectively. Intermittent tensile stresses with different frequencies were applied to each stage chondrocyte. DNA syntheses were examined by measuring the incorporation of [(3)H]thymidine into the cells. Furthermore, the rates of collagen and proteoglycan syntheses were determined by measuring the incorporation of [2,3-(3)H]proline and [(35)S]sulfate into the cells, respectively. At the proliferating stage, intermittent tensions with the frequencies of 30 cycles/min and 150 cycles/min significantly (p < 0.05) upregulated the syntheses of DNA, which indicates the promotion of chondrocyte proliferation. At the matrix-forming stage, collagen, and proteoglycan syntheses also enhanced with increase of the loading frequency. In particular, the intermittent tension with the frequencies of 30 cycles/min and 150 cycles/min increased significantly (p < 0.05 or p < 0.01) both the collagen and proteoglycan syntheses. These results suggest that the proliferation and differentiation of growth plate chondrocytes are regulated by the mechanical loading and that the chondrocyte metabolism enhanced with increase of loading frequency. These may give more insight into the possible mechanism leading to endochondral bone formation.
(キーワード): Animals / Cells, Cultured / Chondrocytes / Collagen / Extracellular Matrix / Extracellular Matrix Proteins / Growth Plate / Male / Mechanotransduction, Cellular / Proteoglycans / Rats / Rats, Wistar / Stress, Mechanical / Tensile Strength / Weight-Bearing
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-008-9462-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18278554; ● Search Scopus @ Elsevier (PMID): 18278554; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-008-9462-7

(DOI: 10.1007/s10439-008-9462-7, PubMed: 18278554) Y Tanne, K Tanimoto, N Tanaka, M Ueki, YY Lin, S Ohkuma, T Kamiya, Eiji Tanaka and K Tanne :
Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation,
Archives of Oral Biology, Vol.53, No.5, 478-487, 2008.

(要約): During endochondral ossification, the production of hyaluronan (HA) is strictly and selectively regulated by chondrocytes, with a temporal peak at the hypertrophic stage. This study was conducted to clarify the effects of HA on expression and activity of runt-related gene 2 (Runx2), a potent transcription factor for chondrocyte differentiation in hypertrophic chondrocytes. Immature chondrocytes from an ATDC5 cell line were cultured and differentiated in DMEM/Ham's F12 with pre-defined supplements. Using real-time PCR, the gene expressions of type II collagen, MMP-13, HAS2, and Runx2 in cultured chondrocytes were analysed from days 0 to 18 of cell differentiation. The activity and expression of Runx2 in hypertrophic chondrocytes were analysed after the treatment with HA oligosaccharide (HAoligo) using AML-3/Runx2 binding, real-time PCR and Western blot analysis. The effects of pre-incubation of anti-CD44 antibody on Runx2 expression were also examined. Expression of type X collagen and Runx2 mRNAs reached a maximum at the terminal differentiation of chondrocytes. The activity and expression of Runx2 was significantly inhibited in hypertrophic chondrocytes treated with HAoligo compared to the untreated controls. High molecular weight-HA did not affect the expression or activity of Runx2. The expression of Runx2 mRNA was significantly decreased in hypertrophic chondrocytes treated with anti-CD44 antibody. These results suggest that HAoligo may affect the terminal differentiation of chondrocytes during the endochondral ossification by inhibiting the expression and activity of Runx2.
(キーワード): Animals / Antigens, CD44 / Blotting, Western / Cell Differentiation / Cell Line, Tumor / Chondrocytes / Collagen Type II / Collagen Type X / Core Binding Factor Alpha 1 Subunit / Gene Expression / Glucuronosyltransferase / Hyaluronic Acid / Matrix Metalloproteinase 13 / Mice / RNA / Reverse Transcriptase Polymerase Chain Reaction / Transcription Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2007.12.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18242579; ● Search Scopus @ Elsevier (PMID): 18242579; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2007.12.007

(DOI: 10.1016/j.archoralbio.2007.12.007, PubMed: 18242579) Eiji Tanaka, Y Iwabuchi, EB Rego, JH Koolstra, E Yamano, T Hasegawa, A Kawazoe, N Kawai and K Tanne :
Dynamic shear behavior of mandibular condylar cartilage is dependent on testing direction,
Journal of Biomechanics, Vol.41, No.5, 1119-1123, 2008.

(要約): Little information is available on the direction-dependency of shear behavior in mandibular condylar cartilage. Therefore, we tested the hypothesis that such a dependency of the dynamic shear properties is present in mandibular condylar cartilage. From each of 17 condyles, two cartilage-bone plugs were dissected and tested in a simple shear sandwich configuration under a compressive strain of 10%. Sinusoidal shear strain (frequency range: 0.01-10 Hz) was applied in the medio-lateral or antero-posterior direction with an amplitude of 1.0%, 2.0%, and 3.0%. The magnitudes of the dynamic shear moduli, as calculated from the resulting shear stress, were found to increase with applied frequency and the shear strain amplitude. The values |G*|, G' and G'' for a medio-laterally applied shear were about 20-33% of those in the antero-posterior shear, although the loss tangent (elasticity/viscosity ratio) was almost the same. In conclusion, the present results clearly show the direction-dependent characteristic of the mandibular condylar cartilage in dynamic shear.
(キーワード): Animals / Cartilage / Elasticity / Mandibular Condyle / Shear Strength / Sus scrofa / Tensile Strength / Viscosity
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jbiomech.2007.12.012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18242620; ● Search Scopus @ Elsevier (PMID): 18242620; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jbiomech.2007.12.012

(DOI: 10.1016/j.jbiomech.2007.12.012, PubMed: 18242620) Eiji Tanaka, MS Detamore and LG Mercuri :
Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment,
Journal of Dental Research, Vol.87, No.4, 296-307, 2008.

(要約): Temporomandibular joint (TMJ) disorders have complex and sometimes controversial etiologies. Also, under similar circumstances, one person's TMJ may appear to deteriorate, while another's does not. However, once degenerative changes start in the TMJ, this pathology can be crippling, leading to a variety of morphological and functional deformities. Primarily, TMJ disorders have a non-inflammatory origin. The pathological process is characterized by deterioration and abrasion of articular cartilage and local thickening. These changes are accompanied by the superimposition of secondary inflammatory changes. Therefore, appreciating the pathophysiology of the TMJ degenerative disorders is important to an understanding of the etiology, diagnosis, and treatment of internal derangement and osteoarthrosis of the TMJ. The degenerative changes in the TMJ are believed to result from dysfunctional remodeling, due to a decreased host-adaptive capacity of the articulating surfaces and/or functional overloading of the joint that exceeds the normal adaptive capacity. This paper reviews etiologies that involve biomechanical and biochemical factors associated with functional overloading of the joint and the clinical, radiographic, and biochemical findings important in the diagnosis of TMJ-osteoarthrosis. In addition, non-invasive and invasive modalities utilized in TMJ-osteoarthrosis management, and the possibility of tissue engineering, are discussed.
(キーワード): Biomechanics / Cartilage, Articular / Dislocations / Humans / Osteoarthritis / Temporomandibular Joint Disorders / Tissue Engineering
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/154405910808700406
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18362309; ● Search Scopus @ Elsevier (PMID): 18362309; ● Search Scopus @ Elsevier (DOI): 10.1177/154405910808700406

(DOI: 10.1177/154405910808700406, PubMed: 18362309) DA Dalla-Bona, Eiji Tanaka, T Inubushi, H Oka, A Ohta, H Okada, M Miyauchi, T Takata and K Tanne :
Cementoblast response to low- and high-intensity ultrasound,
Archives of Oral Biology, Vol.53, No.4, 318-323, 2008.

(要約): It has been shown that ultrasound stimulation accelerates repair of orthodontically induced root resorption. However, the mechanism of such adaptive change is still unclear. The purpose of this study was to evaluate pulsed ultrasound on the differentiation-potential and cementoblast-mediated osteoclastogenesis using a cementoblastic cell line. DESIGN: Cultured cementoblasts (murine cementoblastic cell line, OCCM-30) were subjected to ultrasound exposure (frequency = 1 MHz; pulsed 1:4; spatial average temporal average intensities=30 or 150 mW/cm(2)) or sham exposure for 15 min per day. Expression levels of alkaline phosphatase (ALP), type I collagen (COL-I), osteoprotegerin (OPG) and receptor activator of nuclear factor small ka, CyrillicB ligand (RANKL) mRNAs were analysed by a real-time PCR analysis. Furthermore, ALP activity, collagen synthesis, and protein levels of OPG and RANKL were examined after 6-day ultrasound exposure. RESULTS: Real-time PCR analysis indicated that, irrespective of the intensity, single ultrasound exposure increased the expression of transcripts for COL-I and ALP after 24h; the expression of OPG and RANKL also increased after 1 and 4h, respectively. Cultured cementoblasts receiving ultrasound stimulation for 6 days showed a significant (p<0.05 or 0.01) increase in cell number and collagen synthesis. ALP activity and OPG synthesis were also significantly (p<0.05) upregulated by ultrasound stimulation with 150 mW/cm(2). CONCLUSIONS: These results demonstrated that ultrasound stimulation especially with 150 mW/cm(2) might be a better candidate as a medical remedy to protect against root resorption and/or accelerate its repair.
(キーワード): Alkaline Phosphatase / Animals / Cell Differentiation / Cell Line / Cell Proliferation / Cementogenesis / Collagen Type I / Dental Cementum / Gene Expression Regulation / Mice / Osteoprotegerin / RANK Ligand / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Ultrasonic Therapy
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2007.11.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18163974; ● Search Scopus @ Elsevier (PMID): 18163974; ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2007.11.006

(DOI: 10.1016/j.archoralbio.2007.11.006, PubMed: 18163974) Eiji Tanaka, B Emanuel Rego, Yasunori Iwabuchi, Toshihiro Inubushi, Harm Jan Koolstra, J Eijden Theo M G van, Nobuhiko Kawai, Yasusei Kudo, Takashi Takata and Kazuo Tanne :
Biomechanical response of condylar cartilage-on-bone to dynamic shear.,
Journal of Biomedical Materials Research. Part A, Vol.85, No.1, 127-132, 2008.

(要約): Shear stress can result in fatigue, damage, and irreversible deformation of the mandibular condylar cartilage. However, little information is available on its dynamic properties in shear. We tested the hypothesis that the dynamic shear properties of the condylar cartilage depend on the frequency and amplitude of shear strain. Ten porcine mandibular condyles were used for dynamic shear tests. Two cartilage-bone plugs were dissected from each condyle and tested in a simple shear sandwich configuration under a compressive strain of 10%. Sinusoidal shear strain was applied with an amplitude of 1.0, 2.0, and 3.0% and a frequency range between 0.01 and 10 Hz. The magnitudes of the shear dynamic moduli were found to be dependent on the frequency and the shear strain amplitude. They increased with shear strain. tan delta ranged from 0.2 to 0.4, which means that the cartilage is primarily elastic in nature and has a small but not negligible viscosity. In conclusion, the present results show that the shear behavior of the mandibular condylar cartilage is dependent on the frequency and amplitude of the applied shear strain. The observed shear characteristics suggest a significant role of shear strain on the interstitial fluid flow within the cartilage.
(キーワード): Animals / 生体力学 (biomechanics) / Bone and Bones / Cartilage / Mandibular Condyle / Shear Strength / Stress, Mechanical / Swine
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jbm.a.31500
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17688244; ● Search Scopus @ Elsevier (PMID): 17688244; ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.a.31500

(DOI: 10.1002/jbm.a.31500, PubMed: 17688244) K Tanimoto, A Suzuki, Y Nakatani, T Yanagida, Y Tanne, Eiji Tanaka and Kazuo Tanne :
A case of anterior open bite with severely narrowed maxillary dental arch and hypertrophic palatine tonsils,
Journal of Orthodontics, Vol.35, No.1, 5-15, 2008.

(要約): This case report describes an adolescent patient with an open bite and severely narrowed maxillary dentition and hypertrophic palatine tonsils, treated efficiently with rapid maxillary expansion (RME) and subsequent orthodontic tooth alignment using fixed appliances. The treatment demonstrates that RME can be effective for the correction of a severely narrowed maxillary arch, as well as, in this case, the correction of an anterior open bite in an adolescent patient where no substantial vertical skeletal discrepancy existed.
(キーワード): Adolescent / Cephalometry / Dental Arch / Female / Follow-Up Studies / Humans / Hypertrophy / Malocclusion, Angle Class II / Maxilla / Open Bite / Orthodontic Appliance Design / Palatal Expansion Technique / Palatine Tonsil / Patient Care Planning / Tooth Movement
(出版サイトへのリンク): ● Publication site (DOI): 10.1179/146531207225022356
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18287389; ● Search Scopus @ Elsevier (PMID): 18287389; ● Search Scopus @ Elsevier (DOI): 10.1179/146531207225022356

(DOI: 10.1179/146531207225022356, PubMed: 18287389) Eiji Tanaka, A Nishi-Sasaki, T Hasegawa, C Nishio, N Kawai and Kazuo Tanne :
Skeletal anchorage for orthodontic correction of severe maxillary protrusion after previous orthodontic treatment,
The Angle Orthodontist, Vol.78, No.1, 181-188, 2008.

(要約): The correction of a severe maxillary protrusion in an adult by distal movement of the maxillary molars has been one of the most difficult biomechanical problems in orthodontics. This article reports on the treatment of an adult case of severe maxillary protrusion and a large overjet treated with a skeletal anchorage system. A female patient, age 22 years and 3 months, complained of the difficulty of lip closure due to severe maxillary protrusion with a gummy smile. Overjet and overbite were +7.6 mm and -0.9 mm, respectively. She had a history of orthodontic treatment in which her maxillary first premolars were extracted. In order to conduct distal movement of the maxillary molars, anchor plates were placed in the zygomatic process. After achieving a Class I molar relationship, retraction and intrusion of the maxillary incisors were performed. After a 2-year treatment, an acceptable occlusion was achieved with a Class I molar relationship. Her convex facial profile with upper lip protrusion was considerably improved, and the lips showed less tension in lip closure. After a 2-year retention period, an acceptable occlusion was maintained without recurrence of maxillary protrusion, indicating a stability of the occlusion. The result of this treatment indicated that skeletal anchorage is of great importance as a remedy for achieving intrusion and retraction of the maxillary incisors in cases of severe maxillary protrusion with a patient who had previous orthodontic treatment.
(キーワード): Adult / Bicuspid / Bone Plates / Female / Humans / Incisor / Lip / Malocclusion / Maxilla / Molar / Molar, Third / Orthodontic Anchorage Procedures / Orthodontic Retainers / Retreatment / Serial Extraction / Tooth Movement / Treatment Outcome / Zygoma
(出版サイトへのリンク): ● Publication site (DOI): 10.2319/010307-3.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18193949; ● Search Scopus @ Elsevier (PMID): 18193949; ● Search Scopus @ Elsevier (DOI): 10.2319/010307-3.1

(DOI: 10.2319/010307-3.1, PubMed: 18193949) Eiji Tanaka, MS Detamore, K Tanimoto and Nobuhiko Kawai :
Lubrication of the temporomandibular joint,
Annals of Biomedical Engineering, Vol.36, No.1, 14-29, 2008.

(要約): Although tissue engineering of the temporomandibular joint (TMJ) structures is in its infancy, tissue engineering provides the revolutionary possibility for treatment of temporomandibular disorders (TMDs). Recently, several reviews have provided a summary of knowledge of TMJ structure and function at the biochemical, cellular, or mechanical level for tissue engineering of mandibular cartilage, bone and the TMJ disc. As the TMJ enables large relative movements, joint lubrication can be considered of great importance for an understanding of the dynamics of the TMJ. The tribological characteristics of the TMJ are essential for reconstruction and tissue engineering of the joint. The purpose of this review is to provide a summary of advances relevant to the tribological characteristics of the TMJ and to serve as a reference for future research in this field. This review consists of four parts. Part 1 is a brief review of the anatomy and function of the TMJ articular components. In Part 2, the biomechanical and biochemical factors associated with joint lubrication are described: the articular surface topology with microscopic surface roughness and the biomechanical loading during jaw movements. Part 3 includes lubrication theories and possible mechanisms for breakdown of joint lubrication. Finally, in Part 4, the requirement and possibility of tissue engineering for treatment of TMDs with degenerative changes as a future treatment regimen will be discussed in a tribological context.
(キーワード): Animals / Computer Simulation / Friction / Humans / Lubrication / Models, Biological / Range of Motion, Articular / Synovial Fluid / Temporomandibular Joint
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-007-9401-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17985243; ● Search Scopus @ Elsevier (PMID): 17985243; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-007-9401-z

(DOI: 10.1007/s10439-007-9401-z, PubMed: 17985243)

MISC

Hirofumi Tenshin, Keiichiro Watanabe, Emiko Nakaue, Khurel-Ochir Tsendsuren, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka :
Identification of key determinant for predicting feasible mandibular molars distalization,
Journal of Dental Sciences, 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jds.2022.05.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85132231189

(DOI: 10.1016/j.jds.2022.05.009, Elsevier: Scopus) 田中栄二 :
顎関節症に対する矯正歯科医の役割,
日本顎関節学会雑誌, Vol.25, No.2, 79, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543026030613120

(CiNii: 1572543026030613120) 細木眞紀, 松尾敬志, 永田俊彦, 市川哲雄, 松香芳三, 田中栄二 :
徳島大学病院,
歯科審美, Vol.25, No.2, 196, 2013年.

総説・解説

保坂啓一, 渡邉佳一郎, 田中栄二, 中島正俊, 岩﨑智憲 :
【小児のCR(コンポジットレジン)充填アップデート】接着システムのアップデート,
小児歯科臨床, Vol.28, No.12, 15-26, 2023年12月. 保坂啓一, 鴨居浩平, 田中栄二 :
デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(6)矯正治療とのコンビネーション治療,
日本歯科評論, Vol.82, No.6, 10-13, 2022年6月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010997612859648

(CiNii: 1520010997612859648) Eiji Tanaka, YAO LIU, LINZE XIA, Naoko Ogasawara, Takuma Sakamaki, Fumiya Kano, Noboru Hashimoto, Xingmei Feng and Akihito Yamamoto :
Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review.,
Annals of Biomedical Engineering, Vol.48, No.8, 2158-2170, Jun. 2020.

(要約): Loading is indispensable for the growth, development, and maintenance of joint tissues, including mandibular condylar cartilage, but excessive loading or reduced host adaptive capacity can considerably damage the temporomandibular joint (TMJ), leading to temporomandibular joint osteoarthritis (TMJ-OA). TMJ-OA, associated with other pathological conditions and aging processes, is a highly degenerative disease affecting the articular cartilage. Many treatment modalities for TMJ-OA have been developed. Traditional clinical treatment includes mainly nonsurgical options, such as occlusal splints. However, non-invasive therapy does not achieve joint tissue repair and regeneration. Growing evidence suggests that low-intensity pulsed ultrasound (LIPUS) accelerates bone fracture healing and regeneration, as well as having extraordinary effects in terms of soft tissue repair and regeneration. The latter have received much attention, and various studies have been performed to evaluate the potential role of LIPUS in tissue regeneration including that applied to articular cartilage. The present article provides an overview of the status of LIPUS stimulation used to prevent the onset and progression of TMJ-OA and enhance the tissue regeneration of mandibular condylar cartilage. The etiology and management of TMJ-OA are explained briefly, animal models of TMJ-OA are described, and the effectiveness of LIPUS on cell metabolism and tissue regeneration in the TMJ is discussed.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10439-020-02540-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32514932; ● Search Scopus @ Elsevier (PMID): 32514932; ● Search Scopus @ Elsevier (DOI): 10.1007/s10439-020-02540-x

(DOI: 10.1007/s10439-020-02540-x, PubMed: 32514932) Eiji Tanaka :
An interview with Eiji Tanaka.,
Dental Press Journal of Orthodontics, Vol.20, No.1, 30-39, Jan. 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1590/2176-9451.20.1.030-039.int
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25741822; ● Search Scopus @ Elsevier (PMID): 25741822; ● Search Scopus @ Elsevier (DOI): 10.1590/2176-9451.20.1.030-039.int

(DOI: 10.1590/2176-9451.20.1.030-039.int, PubMed: 25741822) M. J. Lamela, Y. Prado, P. Fernández, A. Fernández-Canteli and Eiji Tanaka :
1. Lamela MJ, Pelayo F, Ramos A, Fernandez-Canteli A, Tanaka E. (2014): Analysis of compressive properties of porcine temporomandibular joint disc., --- Proceedings of the Conference Materials Structure & Micromechanics of Fracture VII, July 1-3, 2013, Brno, Czech Republic (Key Engineering Materials Vol. 592-593: 354-357). ---,
2014. Shingo Kuroda and Eiji Tanaka :
Risks and complications of miniscrew anchorage in clinical orthodontics,
Japanese Dental Science Review, Vol.50, No.4, 79-85, Nov. 2014.

(要約): SummaryMiniscrew anchorage has greatly expanded the limit of clinical orthodontics. Even without patient compliance, miniscrews can provide stationary anchorages for various tooth movements and even make it possible to move the tooth in directions which have been impossible with traditional orthodontic mechanics. On the other hand, the clinical use of miniscrew anchorage includes some risks. Screw fracture might be one of the most undesirable side effects in clinical use of miniscrew anchorage, which occurs in not only the placement but also the removal. A lot of factors are suggested to relate with screw failure, but screw-root proximity and the mandible are considered as two common factors. Damages of soft tissues are temporary in most cases, but damages of hard tissues are irreversible and should be avoided. We have to understand these risks and complications of miniscrew anchorage, and pay attention for their safety-conscious use.
(キーワード): Miniscrew / Anchorage / 臨床矯正歯科学 (clinical orthodontics) / Screw fracture / Screw failure / Success rate
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jdsr.2014.05.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdsr.2014.05.001

(DOI: 10.1016/j.jdsr.2014.05.001) Eiji Tanaka :
Mechanism of functional overloading for TMJ degenerative disorders, --- Etiology, mechanism, and management. ---,
Journal of Taiwan Orthodontic Society, Vol.2, No.2, 27-49, Feb. 2010. 井澤俊, 石丸直澄, 田中栄二, 林良夫 :
RANKLとFasシグナルクロストークによる樹状細胞の機能調節機構,
臨床免疫·アレルギー科, Vol.52, No.5, 471-477, 2009年11月.

(キーワード): RANK/RANKL signal / Fas/FasL signal / dendritic cell / apoptosis / rheumatoid arthritis / rank/rankl signal / fas/fasl signal
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522543655149137152

(CiNii: 1522543655149137152) 田中栄二 :
顎関節の潤滑機能,
四国歯学会雑誌, Vol.21, No.2, 319-325, 2009年1月.

(徳島大学機関リポジトリ): ● Metadata: 109778

(徳島大学機関リポジトリ: 109778) 宮内睦美, 山野栄三, 田中栄二, 今中宏真, 水道裕久, 牧野武利, 丹根一夫, 高田隆 :
歯周病とラクトフェリン-基礎研究から臨床応用までリポソーム化ラクトフェリン経口投与がリポポリサッカライド誘導歯周組織破壊に及ぼす抑制効果,
歯界展望, Vol.112, 728-729, 2008年10月.

講演・発表

Eiji Tanaka, H Yamada, M Higashino, S Suetake and S Abe :
Influence of orthodontic treatment on changes in the maxillary sinus dimensions South Jordan, Utah, USA. (e-Poster),
10th Annual Roseman University Research Symposium, South Jordan, Utah, USA., Feb. 2024. Eiji Tanaka :
Idiopathic Condylar Resorption Etiology, diagnosis, and orthodontic treatment,
16th Indonesian Association of Orthodontists Meeting, Makassar, South Sulawesi, Indonesia., Sep. 2023. Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka :
DEVELOPMENT OF SMART DENTAL CEMENT ELECTRICALLY DEBONDABLE ON-DEMAND: EFFECTS OF IMMERSION IN SODIUM CHLORIDE SOLUTION,
Biomaterials International 2023, Sapporo, Jul. 2023. Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka :
Effects of Immersion in NaCl Solutions on Shear Bond Strength and Electric Conductivity of a Dental Cement,
The 7th International Symposium on Biomedical Engineering (ISBE2022), Nov. 2022. Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka :
Shear bond strength change due to current application of resin-modified glass-ionomer-cement immersed in NaCl solutions,
International Dental Materials Congress 2022, Nov. 2022. Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Takeshi Harada, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Tomoyo Hara, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
Mechanical unloading promotes bone destruction and myeloma tumor expansion,
Cancer and bone society young investigator symposium, Online, Feb. 2022. Hirofumi Tenshin, Takeshi Harada, Yusuke Inoue, Jumpei Teramachi, Masahiro Hiasa, Sou Shimizu, Emiko Nakaue, Kotaro Tanimoto, Yoshiki Higa, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Targeting SLAMF7 to disrupt myeloma-osteoclast interaction: elotuzumabs ADCC activity with Th1-like gamma delta T cells towards osteoclasts and myeloma cells.,
Cancer and bone society young investigator symposium, Feb. 2022. Eiji Tanaka :
Introduction of accelerated orthodontic tooth movement by a low-intensity pulsed ultrasound exposure,
First National Symposium of Mongolian Dentistry, Ulanbaator, Mongolia. (Webinar meeting), Dec. 2021. Eiji Tanaka :
Orthodontic approach to children with obstructive sleep apnea syndrome,
FORSILA 2021, Semarang, Indonesia. (Webinar meeting), Aug. 2021. Kenichi Hamada, Hiroko Sato, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka :
Change of electric and mechanical properties of ionic-liquid containing ``smart'' resin-modified glass-ionomer-cement with water immersion,
Thermec' 2021, Wien, Jun. 2021. Hirofumi Tenshin, Takeshi Harada, 井上雄介, Jumpei Teramachi, Masahiro Hiasa, 小田明日香, Kotaro Tanimoto, Sou Shimizu, Yoshiki Higa, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Tomoko Maruhashi, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
The anti-SLAMF7 elotuzumab enhances ADCC activity with Th1-like γδT cells towards osteoclasts and myeloma cells.,
The European Calcified Tissue Society 2021 Digital Congress 2021, web, Mar. 2021. Kenichi Hamada, Hiroko Sato, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka :
Water immersion effects on bonding strength of dental cement containing ionic-liquid,
11th World Biomaterials Congress, Glasgow, Dec. 2020. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Takeshi Harada, Eiji Tanaka, Kotaro Tanimoto, Sou Shimizu, Masahiro Oura, Kimiko Sogabe, Masahiro Abe, Toshio Matsumoto and Itsuro Endo :
The novel therapeutic approaches with TAK1 inhibition against the aberrant NLRP3 inflammasome activation in rheumatoid arthritis,
ECTS 2020 Digital Congress, Oct. 2020. Yuta Matsuki, Hiroko Sato, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada :
Electrolytic solution immersion effects on novel glass ionomer cement -Change of electric conductivity and shear bonding reduction after current application-,
9th IOC, Yokohama, Oct. 2020. Akihiko Iwasa, Naoko Ogasawara, Mohannad Ashtar, Masaki Sawada, Shinya Horiuchi and Eiji Tanaka :
An orthodontic treatment using the miniscrew for a patient with aromatase inhibitor-induced bone density reduction.,
9th IOC, Yokohama, Oct. 2020. Toyoaki Takagi, Sou Shimizu and Eiji Tanaka :
Mandibular deviation and unilateral posterior crossbite treated with minicrew-assisted radid palatal expander.,
9th IOC, Yokohama, Oct. 2020. Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Masahiro Abe and Eiji Tanaka :
Immobilization accelerates bone loss and myeloma tumor expansion.,
9th IOC, Yokohama, Oct. 2020. Mohannad Ashtar, Hirofumi Tenshin, Masahiro Abe and Eiji Tanaka :
The effects of Febuxostat on RANKL-induced bone resorption.,
9th IOC, Yokohama, Oct. 2020. Kaoru Yoshinaga, Akihiro Yasue, Seiichi Oyadomari and Eiji Tanaka :
In vivo elucidation of the effect on the number of teeth caused by double mutant of WNT10A and WNT10B.,
9th IOC, Yokohama, Oct. 2020. Hiroko Sato, Yuta Matsuki, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada :
Water immersion effects on novel glass ionomer cement containing ionic liquid Changes of electric effects on novel glass ionomer cement containing ionic liquid-.,
9th IOC, Yokohama, Oct. 2020. Keiichiro Watanabe, B Mitchell, Y Hirai, D-G Kim, T Deguchi and Eiji Tanaka :
Mechanical characteristic of a novel thread shape of miniscrew.,
9th IOC, Yokohama, Oct. 2020. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Ashtar Mohannad, Kotaro Tanimoto, Soh Shimizu, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
The role of NLRP3 inflammasome activation in joint inflammation and destruction in rheumatoid arthritis: novel therapeutic approaches with TAK1 inhibition.,
29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting, Oct. 2019. Susumu Abe, Hiroki Mori, Eiji Tanaka, Tachibana Naoko, Murakami Ayu, Kazuo Okura, Yoshitaka Suzuki, Toshinori Okawa and Fumiaki Kawano :
Craniofacial morphology in OSA patients treated by oral appliance with and without sufficient effects,
2019 World Sleep Congress, Sep. 2019. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Ashtar Mohannad, Kotaro Tanimoto, Masami Iwasa, Bat-Erdene Ariunzaya, Takeshi Harada, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
TAK1 inhibition effectively alleviates joint inflammation as well as bone destruction in rheumatoid arthritis: Suppression of NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption,
American Society for Bone and Mineral Society Annual meeting 2019, Orlando, Florida, USA,, Sep. 2019. Jumpei Teramachi, Soh Shimizu, Hirofumi Tenshin, Bat-Erdene Ariunzaya, Masahiro Hiasa, Kotaro Tanimoto, Oda Asuka, Takeshi Harada, Mohannad Ashtar, Kotaro Tanimoto, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
A progressive auto-amplification loop in TAK1 expression and activation in MM cells.,
ASBMR 2019,, Orlando, Florida, USA., Sep. 2019. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Oda Asuka, Ashtar Mohannad, Kotaro Tanimoto, Masami Iwasa, Bat-Erdene Ariunzaya, Takeshi Harada, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
TAK1 inhibition effectively alleviates joint inflammation as well as bone destruction in rheumatoid arthritis: Suppression of NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption.,
ASBMR 2019,, Orlando, Florida, USA., Sep. 2019. Eiji Tanaka :
Orthodontic approach to the establishment of aesthetic smile by use of temporary anchorage devices.,
7th Meeting of Mongolian Association of Orthdontists, Special presentation,, Tereji, Mongolia., Aug. 2019. Susumu Abe, Hiroki Mori, Eiji Tanaka, N Tachibana, A Murakami, Kazuo Okura, Yoshitaka Suzuki, Toshinori Okawa and Fumiaki Kawano :
Craniofacial morphology in OSA patients treated by oral appliance with and without sufficient effects.,
World Sleep 2019, Vancouver, Jun. 2019. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Masahiro Abe and Eiji Tanaka :
Effective suppression of inflammasome-mediated joints destruction by TAK1 inhibition,
第97回IADR学術大会, Vancouver, Jun. 2019. Islamy Rahma Hutami, Eiji Tanaka and Takashi Izawa :
Hypoxia Inducible Factor-1α Regulates the Palatal Wound Healing via M1/M2 Macrophage Reprogramming.,
Association of Orthodontists (Singapore) Congress,, Singapore, Feb. 2019. Mohannad Ashtar, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Oda Asuka, Iwasa Masami, Takeshi Harada, Bat-Erdene Ariunzaya, Kimiko Sogabe, Masahiro Oura, Shiroh Fujii, Kumiko Kagawa, Shingen Nakamura, Hirokazu Miki, Toshio Matsumoto, Masahiro Abe and Eiji Tanaka :
Peri-implantitis and the role of Febuxostat in osteoclast differentiation.,
AEEDC Dubai World Orthodontic Conference, Dubai, UAE, Feb. 2019. Eiji Tanaka :
Treatment of severe maxillary hypoplasia with combined orthodontics and distraction osteogenesis,
AEEDC Dubai World Orthodontic Conference, Special presentation,, Dubai, UAE., Feb. 2019. Eiji Tanaka :
Surgical-orthodontic treatment for jaw deformities-Its indications, aims, treatment goal and procedures.,
AEEDC Dubai World Orthodontic Conference, Special presentation,, Dubai, UAE., Feb. 2019. Eiji Tanaka :
Integrated Orthodontic Treatment by use of Temporary Anchorage Devices-from the consultation to treatment planning.,
Dubai World Dental Meeting Pre-conference course,, Dubai, UAE., Feb. 2019. Islamy Rahma Hutami, Eiji Tanaka and Takashi Izawa :
Fas/S1P1 crosstalk via NF-kB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis,
American Society for Bone and Mineral Research 2018 Annual Meeting, 132, Montreal, Sep. 2018.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL) / 自己免疫 (autoimmunity) / アポトーシス (apoptosis)

Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Oda Asuka, Ashtar Mohannad, Kotaro Tanimoto, Iwasa Masami, Bat-Erdene Ariunzaya, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Opposite effects of TRAIL on the Sp-1-c-FLIP survival pathway in myeloma cells and osteoclasts.,
ASBMR 2018 Annual Meeting, Montreal, Sep. 2018. Eiji Tanaka :
Orthodontic approach to progressive condylar resorption of temporomandibular joint.,
6th Meeting of Mongolian Association of Orthdontists,, Ulaanbaatar, Mongolia., Sep. 2018. Tsendsuren Khurel-Ochir, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
The role of p21 on the development of TMJ-OA,
6th Meeting of Mongolian Association of Orthdontists,, Ulaanbaatar, Mongolia., Sep. 2018.

(キーワード): TMJ-OA / 細胞周期 (cell cycle)

Islamy Rahma Hutami, Hiroki Mori, Tsendsuren Khurel-Ochir, Akiko Mino, Akihiko Iwasa, Eiji Tanaka and Takashi Izawa :
HIF-1alpha regulates the palatal wound healing through M1/M2 macrophage reprogramming,
96th General Session & Exhibition of the IADR, 214, London, Jul. 2018.

(キーワード): 創傷治癒 / 低酸素応答遺伝子

Hirofumi Tenshin, Jumpei Teramachi, Ryota Amachi, Masahiro Hiasa, Keiichiro Watanabe, Toshio Matsumoto, Masahiro Abe and Eiji Tanaka :
Apoptosis inducer TRAIL stimulates osteoclast differentiation and survival via TAK1 activation.,
1st International Conference of Biophysical Technology in Dentistry (+10th International Scientific Meeting in Dentistry),, Makassar, Indonesia., Apr. 2018. Eiji Tanaka :
Orthodontic approach to progressive condylar resorption of the temporomandibular joint.,
1st International Conference of Biophysical Technology in Dentistry (+10th International Scientific Meeting in Dentistry),, Makassar, Indonesia., Apr. 2018. Takashi Izawa, Rieko Arakaki, Eiji Tanaka and Naozumi Ishimaru :
Crosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone homeostasis,
Gordon Research Conference; "Bones and Teeth" From Skeletal and Dental Stem Cells to Rare Bone Disease and Integrative Physiology, Houston, Jan. 2018.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL)

Hirofumi Tenshin, Jumpei Teramachi, Ryota Amachi, Masahiro Hiasa, Keiichiro Watanabe, Toshio Matsumoto, Masahiro Abe and Eiji Tanaka :
Apoptosis inducer TRAIL stimulates osteoclast differentiation and survival via TAK1 activation.,
The 4th ASEAN plus Tokushima Joint International Conference, Bali, Indonesia, Dec. 2017. Eiji Tanaka :
Orthodontic approach to progressive condylar resorption in the temporomandibular joint.,
Special lecture in the orthodontic meeting in Nantong University, Nantong, China., Nov. 2017. Eiji Tanaka :
Diagnosis and tearment of malocclusion.,
General lecture in Nantong University, Nantong, China., Nov. 2017. Takashi Izawa, Eiji Tanaka and Naozumi Ishimaru :
The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis,
ASBMR 2017 Annual Meeting, Denver, Sep. 2017. Eiji Tanaka :
Diagnosis and tearment of malocclusion,
General lecture in UNISSULA, Semarang, Indonesia., Aug. 2017. Hirofumi Tenshin, Jumpei Teramachi, A Oda, Ryota Amachi, Masahiro Hiasa, A Baterdene, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Osteoclasts utilize TRAIL for their NF-B activation, but TAK1 inhibition resumes TRAIL-induced apoptosis in osteoclasts.,
Australian and New Zealand Bone and Mineral Society 2017, Brisbane, Australia., Jun. 2017. Eiji Tanaka :
Surgical-orthodontic diagnosis and treatment -Its indications, aims, treatment goal and procedures,
Nantong University Medical School, Nantong, China., May 2017. Eiji Tanaka :
Introduction of accelerated orthodontic tooth movement by a low-intensity pulsed ultrasound exposure.,
2017 Annual Session of the American Association of Orthodontists,, San Diego, Apr. 2017. Ryota Amachi, Masahiro Hiasa, Oda Asuka, Bat-Erdene Ariunzaya, Jumpei Teramachi, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiroh Fujii, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
Osteoblast Creates a Non-permissive Niche for Myeloma Cells,
95th General Session & Exhibition of the IADR program book, San Francisco, Mar. 2017. Hirofumi Tenshin, Jumpei Teramachi, Ryota Amachi, Masahiro Hiasa, Keiichiro Watanabe, Toshio Matsumoto, Masahiro Abe and Eiji Tanaka :
TRAIL Stimulates Osteoclast Differentiation and Survival via TAK1 Activation.,
95th General Session & Exhibition of the IADR program book, San Francisco, Mar. 2017. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Akihiko Iwasa and Eiji Tanaka :
Fas/S1P1 signaling controls temporomandibular joint subchondral bone remodeling in autoimmune-arthritis.,
95th General Session & Exhibition of the IADR program book, 243, San Francisco, Mar. 2017. Minami Sato, Mutsumi Fujita, Akihiko Iwasa, Hiroki Mori, Akiko Mino, Natsuko Hichijo, Shinya Horiuchi and Eiji Tanaka :
Effect of Low-intensity Pulsed Ultrasound on ATDC5 Cells Under Inflammation,
95th General Session & Exhibition of the IADR program book, San Francisco, Mar. 2017. Hiroki Mori, Takashi Izawa, Takehiro Shinohara, Akiko Mino, Minami Sato, Natsuko Hichijo, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
Effect of Rebamipide administration on TMJ-OA model mouse.,
95th General Session & Exhibition of the IADR program book, 207, San Francisco, Mar. 2017. Akihiro Yasue, Silvia Naomi Mitsui Akagi, Daishi Arai, Seiichi Oyadomari, Keita Sato, Junji Inoue, Seiichi Oyadomari and Eiji Tanaka :
In vivo DNA deletion assay of MSX1 gene in mice using CRISPR/Cas system,
JOINT MEETING of the German and Japanese Societies of Developmental Biologists, Kiel, Germany, Mar. 2017. Akihiro Yasue, Silvia Naomi Mitsui Akagi, Daishi Arai, Seiichi Oyadomari and Eiji Tanaka :
In vivo DNA deleiton assay of Msx1 gene in mice using CRISPR/Cas system,
Joint Meeting of the German and Japanese Societies of Developmental Biologists, Kiel, Germany, Mar. 2017. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices.,
Seminar in Sri Hasanamba Dental College & Hospital, Hassan, Karnataka, India., Feb. 2017. Eiji Tanaka :
Temporomandibular Joint disorders. Its Aetiology, Diagnosis and Orthodontic Approach.,
Seminar in Sri Hasanamba Dental College & Hospital, Hassan, Karnataka, India., Feb. 2017. Eiji Tanaka :
Surgical-orthodontic diagnosis and treatment -Its indications, aims, treatment goal and procedures-,
Indian Dental Association, Hassan, Karnataka, India., Feb. 2017. Eiji Tanaka :
Orthodontic approach to temporomandibular disorder,
Bali Dental Science and Exhibition (Dence), Denpasar, Indonesia., Sep. 2016. Eva Barrientos, Fernández Pelayo, Eiji Tanaka, Jesús María Lamela-Rey, Alfonso Fernández-Canteli and JC Vicente :
Viscoelastic characterization and numerical simulation of the whole TMJ disc for static and dynamic loadings.,
TMJ Bioengineering Conference, Barcelona, Sep. 2016.

(要約): 4.Barrientos E, Pelayo F, Tanaka E, Lamela MJ, Canteli A, de Vicente JC.

M Iwata, 黒田優子, K Matsumoto, T Shinohara and Eiji Tanaka :
Five-year prognosis of a patient with malocclusion who underwent comprehensive treatment for severe periodontitis.,
102nd Annual Meeting of American Academy of Periodontology, San Diego, Sep. 2016. Hirofumi Tenshin, Jumpei Teramachi, A Oda, Ryota Amachi, Bingzi Dong, Masahiro Hiasa, Keiichiro Watanabe, Ryota Amachi, S Nakamura, H Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Osteoclasts utilize an apoptosis-inducer TRAIL as a stimulator for osteoclastogenesis Critical roles of the TAK-1-Pim-2 signaling induced by RANK ligand and TRAIL.,
ANZBMS 2016 Annual Meeting, Gold Coast, Aug. 2016. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices.,
Lecture in Nantong University Medical School, Nantong, China., Jul. 2016. Hiroki Mori, Takashi Izawa and Eiji Tanaka :
Role of Rho-GTP/S1P/Smad3 Signaling on the Pathogenesis of TMJ-OA.,
International Association for Dental Research General Session, Seoul, Jun. 2016. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Kiyoshi Masuda, Takuya Naruto, Seiichi Oyadomari, Sumihare Noji, Issei Imoto and Eiji Tanaka :
Conserved C-terminal domain of MSX1 is essential for tooth development,
12th Tooth Morphogenesis and Differentiation conference, Porvoo, Finland, Jun. 2016. Akihiro Yasue, Takuya Naruto, Silvia Naomi Mitsui Akagi, Tomohiro Komoto, Issei Imoto and Eiji Tanaka :
Detection of small deletion in PAX9 gene in a Japanese family with oligodontia by combined targeted resequencing and quantitative PCR analysis,
12th Tooth Morphogenesis and Differentiation conference, Porvoo, Finland, Jun. 2016. Eiji Tanaka :
Orthodontic approach to the establishment of aesthetic smile by use of temporary anchorage devices,
Dream2016, Yogyakarta, Indonesia, May 2016. MANSJUR KARIMA QURNIA, Minami Sato and Eiji Tanaka :
Combined therapeutic effects of parathyroid hormone and low-intensity pulsed ultrasound enhance bone fracture healing in osteoporotic rats,
2016 AADR/CADR Annual Meeting & Exhibition, Los Angels, CA, USA, Mar. 2016. Minami Sato, MANSJUR KARIMA QURNIA and Eiji Tanaka :
Low-intensity pulsed ultrasound rescues insufficient salivary secretion in Sjogren syndrome,
2016 AADR/CADR Annual Meeting & Exhibition, Los Angels, CA, USA, Mar. 2016. Hirofumi Tenshin, Jumpei Teramachi, A Oda, Ryota Amachi, Masahiro Hiasa, Keiichiro Watanabe, S Nakamura, H Miki, I Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
TRAIL is not a proapoptotic but rather anti-apoptotic mediator for osteoclasts to stimulate their differentiation and survival,
ASBMR 2015 Annual Meeting, Seattle, Oct. 2015. Hiroki Mori, Takashi Izawa and Eiji Tanaka :
Smad3 deficiency leads to mandibular condyle degeneration via the Sphingosine 1-phosphate (S1P)/ S1P3 signaling axis,
ASBMR 2015 Annual Meeting, 143, Seattle, Oct. 2015. Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiroh Fujii, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Up-regulation of the pH sensor TRPV1 in myeloma cells and their adaption to an acidic microenvironment,
ASBMR 2015 Annual Meeting, Seattle, Oct. 2015. Takeshi Kondo, Itsuro Endo, Ken-ichi Aihara, nishi Oh Yukiyo, Bingzi Dong, Kiyoe Kurahashi, Sumiko Yoshida, Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Masahiro Abe, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Serum carboxy-terminal telopeptide of type I collagen, as a marker for systemic atherosclerosis,
ANZBMS 2015 Annual Meeting, Hobart, Sep. 2015. Eiji Tanaka :
Surgical-orthodontic diagnosis and treatment-Its indications, aims, treatment goal and procedures-,
Ulanbaatar, Mongolia, Jul. 2015. Eiji Tanaka :
Orthodontic approach to patients with TMJ-internal derangement,
FORSILA II 2015, Semarang, Indonesia, May 2015. A Nakajima, R Sano, Y Suzuki, Y Ito, Eiji Tanaka, M Maeno, K Iwata, N Shimizu and CF Shuler :
Functional role of TGF- receptors during palatal fusion in vitro,
93rd IADR, Vol.59, No.11, 1192-1204, Boston, Mar. 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.archoralbio.2014.07.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25105252; ● Summary page in Scopus @ Elsevier: 2-s2.0-84905682284

(DOI: 10.1016/j.archoralbio.2014.07.007, PubMed: 25105252, Elsevier: Scopus) Natsuko Hichijo, Nobuhiko Kawai, LJ Ruijven van, GEJ Langenbach and Eiji Tanaka :
Effects of decreased occlusal loading on the mandibular bone characteristics,
93rd IADR, Boston, Mar. 2015. Silvia Naomi Mitsui Akagi, Akihiro Yasue and Eiji Tanaka :
Mutation affecting the C-terminal of MSX1 causes non-syndromic tooth agenesis,
93rd IADR, Boston, Mar. 2015. Hiroki Mori, Takashi Izawa and Eiji Tanaka :
Role of Smad3 and lysophospholipid receptor S1P3 signaling in the pathogenesis of TMJ-OA,
The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014. Minami Sato, Kumiko Nagata, Shingo Kuroda, MANSJUR KARIMA QURNIA, Shinya Horiuchi, Yoshiko Yamamura, Masayuki Azuma and Eiji Tanaka :
Effects of low-intensity pulsed ultrasound on salivary gland,
The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014. Natsuko Hichijo, Eiji Tanaka, Nobuhiko Kawai, ODO BAYARSAIKHAN, LJ Ruijven van and GEJ Langenbach :
Effects of decreased occlusal loading on the mandibular bone characteristics,
The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014. Silvia Naomi Mitsui Akagi, Akihiro Yasue, K Matsuda, Keiichiro Watanabe, Shinya Horiuchi, Issei Imoto and Eiji Tanaka :
Sequence analysis and in vitro study of novel mutations identified in patients with tooth agenesis,
The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014. MANSJUR KARIMA QURNIA, Shingo Kuroda and Eiji Tanaka :
Combined effects therapy of recombinant parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound on osteoporotic bone fracture healing in rats,
The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014. Akihiro Yasue, Silvia Naomi Mitsui Akagi, Teppei Watanabe, T Sakuma, Seiichi Oyadomari, T Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka :
Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems,
X meeting for Spanish Society for Developmental Biology (SEBD), Madrid, Oct. 2014. Nobuhiko Kawai, Katsuya Hirasaka, Chieko Shiota, Takeshi Nikawa and Eiji Tanaka :
Effectiveness Of Myostatin Knockdown On Jaw Muscle Activity,
2014 IADR/PER Congress, Dubrovnik, Croatia., Sep. 2014. Hiroyo Mori, Nobuhiko Kawai, ODO BAYARSAIKHAN, Natsuko Hichijo, Nao Kinouchi and Eiji Tanaka :
The inhibition of skeletal muscle atrophy with anti-ubiquitination oligopeptide,
2014 IADR/PER Congress, Dubrovnik, Croatia., Sep. 2014. MANSJUR KARIMA QURNIA, Shingo Kuroda and Eiji Tanaka :
2.Mansjur KQ, Kuroda S, Tanaka EThe effectiveness of low-intensity pulsed ultrasound on the fracture healing of osteoporotic bones,
8th International Dental Scientific Meeting, Makassar, Indonesia, Jun. 2014. Eiji Tanaka :
Orthodontic approach to the establishment of aesthetic smile using temporary anchorage devices,
8th International Dental Scientific Meeting, Jun. 2014. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
Pathologenesis of Sjogren's syndrome through Aromatase and adipose tissue.,
International Congress on Autoimmunity, Niece, Mar. 2014. Akihiro Yasue, Silvia Naomi Mitsui Akagi, H Watanabe, T Sakuma, Seiichi Oyadomari, T Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka :
A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system.,
International Symposium on RNAi and Genome Editing Methods, Tokushima, Mar. 2014. Eiji Tanaka :
Mechanism of Temporomandibular Joint Osteoarthritis: Aetiology, Diagnosis and Orthodontic Approach,
3rd Dental Technology Exhibition and Meeting, Batu, Malang, Indonesia, Feb. 2014. Ryota Amachi, Masahiro Abe, Masahiro Hiasa, Keiichiro Watanabe, S Fujii, T Harada, H Miki, S Nakamura, I Endo, Eiji Tanaka and Toshio Matsumoto :
Acidic conditions epigenetically repress the TRAIL receptor DR4 in myeloma cells to confer their resistance to TRAIL,
ASBMR 2013 Annual Meeting,, Baltimore, Oct. 2013. Keiichiro Watanabe, Masahiro Abe, H Mori, Ryota Amachi, Masahiro Hiasa, T Harada, S Fujii, S Nakamura, H Miki, K Kagawa, I Endo, Eiji Tanaka and Toshio Matsumoto :
Potent induction of bone formation in myeloma bone lesions by the cathepsin K inhibitor KK1-300-01 in combination with the proteasome inhibitor bortezomib,
ASBMR 2013 Annual Meeting,, Baltimore, Oct. 2013. Shingo Kuroda, C Nishio, RM Wazen, JDS Neves, Eiji Tanaka, A Nanci and P Moffatt :
Expression of the osteoblast membrane protein Bril in tooth and periodontal tissues during development and following tooth movement,
The 65th Annual Scientific Session of Canadian Orthodontic Association (CAO), Alberta, Canada., Sep. 2013. Jesús María Lamela, Fernández Pelayo, Alberto Ramos, Alfonso Fernández-Canteli and Eiji Tanaka :
Analysis of compressive properties of porcine temporomandibular joint disc.,
Materials Structure & Micromechanics of Fracture VII, July 1-3, 2013, Brno, Czech Republic., Brno, Jul. 2013. Eiji Tanaka :
Orthodontic approach to acquired open bite involved in. TMJ osteoarthritis.,
TMJ Workshop: Advances in the Study of Temporomandibular Joint Pathology, Dr. Llorente Oral and Maxillofacial Surgery,, Oviedo, Spain., Jun. 2013. Eiji Tanaka :
Basic concept in the etiology and diagnosis of temporomandibular joint disorders,
TMJ Workshop: Advances in the Study of Temporomandibular Joint Pathology, Dr. Llorente Oral and Maxillofacial Surgery,, Oviedo, Spain., Jun. 2013. Eiji Tanaka :
Orthodontic approach to TMJ-osteoarthritis with jaw deformity,
FORSILA KG 2013, Semarang, Indonesia., May 2013. Keiichiro Watanabe, Masahiro Abe, Ryota Amachi, Masahiro Hiasa, T Harada, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, H Mori, Itsuro Endo, Eiji Tanaka and Toshio Matsumoto :
Induction of bone formation in myeloma osteolytic lesions by cathepsinK inhibition,
Kyoto, Apr. 2013. Ryota Amachi, Keiichiro Watanabe, Shiroh Fujii, T Harada, Hirokazu Miki, Shingen Nakamura, A Oda, Masahiro Hiasa, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
An acidic milieu suppersses histone acetylation in myeloma cells to down-regulate the TRAIL receptor DR4 expression.,
Kyoto, Apr. 2013. Eiji Tanaka :
Orthodontic approach to temporomandibular disorders: Long-term follow-up,
10th National Congress of Indonesian Dental Association & 4th Makassar Scientific Meeting, Special Lecture, Makassar Grand Clarion Hotel & Convention Makassar, Indonesia., Mar. 2013. Naoko Yoneda, Akihiro Yasue and Eiji Tanaka :
6.Yoneda N, Yasue A, Tanaka E. Effects of Smad3 gene inhibition on scar formation,
ASEAN plus and Tokushima Joint International Conference, Yogjakarta, Indonesia, Dec. 2012. Ryota Amachi, Masahiro Abe, Ryota Amachi, Keiichiro Watanabe, S Fujii, T Harada, H Miki, S Nakamura, A Oda, Masahiro Hiasa, Eiji Tanaka and Toshio Matsumoto :
An acidic milieu suppresses DR4 editing to cause myeloma resistance to TRAIL,
ASEAN plus and Tokushima Joint International Conference, Yogjakarta, Indonesia, Dec. 2012. Keiichiro Watanabe, Masahiro Abe, Ryota Amachi, Masahiro Hiasa, T Harada, S Fujii, S Nakamura, H Miki, K Kagawa, H Mori, I Endo, Eiji Tanaka and Toshio Matsumoto :
Restoration of bone formation in myeloma osteolytic lesions by the cathepsin K inhibitor KK1-300-01,
34th ASBMR meeting, Minneapolis, MN, USA., Oct. 2012. P Fernandez, MJ Lamela, A Ramos, A Fernandez-Canteli and Eiji Tanaka :
Viscoelastic dynamic characterization of the porcine temporomandibular joint disc under compression,
3rd TMJ Bioengineering Conference, Pittsberg, PA, USA., Sep. 2012. Keiichiro Watanabe, Masahiro Abe, Hiroyo Mori, Ryota Amachi, Masahiro Hiasa, T Harada, S Fujii, S Nakamura, H Miki, K Kagawa, I Endo, Eiji Tanaka and Toshio Matsumoto :
The cathepsin K inhibitor KK1-300-01 prevents bone destruction and resumes bone formation in myeloma osteolytic lesions,
Australian & New Zealand Bone & Mineral Society 22th Annual Scientific Meeting with 1st Asia-Pacific Bone and Mineral Research meeting, Perth, Australia., Sep. 2012. Eiji Tanaka :
Orthodontic approach to temporomandibular disorders: Long-term stability,
Orthodontic Seminar in Mongolia, August 1, 2012, Ulan Bator, Mongolia., Aug. 2012. MJ Lamela, P Fernandez, D Dorantes, A Ramos, Eiji Tanaka, A Arguelles and A Fernandez-Canteli :
Experimental biomechanical characterization and numerical analysis of the temporomandibular joint,
15th International Conference on Experimental Mechanics, Porto, Portugal, Jul. 2012. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Yoshio Hayashi and Eiji Tanaka :
Hyperfunctions of osteoclasts in a rheumatoid arthritis model,
ASBMR 2011 Annual Meeting, San Diego, Sep. 2011. Keiichiro Watanabe, Masahiro Abe, M Kawatani, Masahiro Hiasa, A Kawano, T Jinno, T Harada, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Kyoko Takeuchi, Shuji Ozaki, Eiji Tanaka, H Osada and Toshio Matsumoto :
Aggravation of myeloma growth and drug resistance by an acidic created in myeloma-osteoclast interaction.,
ASBMR 2011 Annual Meeting, San Diego, Sep. 2011. Masahiro Hiasa, nakano ayako, Keiichiro Watanabe, C Qu, T Harada, Shiroh Fujii, Hirokazu Miki, Shingen Nakamura, Kumiko Kagawa, Kyoko Takeuchi, Eiji Tanaka, Kenzo Asaoka, Shuji Ozaki, Toshio Matsumoto and Masahiro Abe :
Prevention of tumor growth and bone destruction in myeloma by Pim kinase inhibition.,
ASBMR 2011 Annual Meeting, San Diego, Sep. 2011. Masahiro Hiasa, nakano ayako, Keiichiro Watanabe, C Qu, T Harada, Shiroh Fujii, Hirokazu Miki, Shingen Nakamura, Kumiko Kagawa, Kyoko Takeuchi, Eiji Tanaka, Kenzo Asaoka, Shuji Ozaki, Toshio Matsumoto and Masahiro Abe :
Dual effects of Pim inhibition on myeloma: induction of bone formation and tumor suppression.,
IOF-ANZBMS 2011 Annual Meeting, Gold Coast, Sep. 2011. Eiji Tanaka :
Orthodontic approach to TMJ osteoarthritis with jaw deformity,
International Symposium for Temporomandibular Disorder, Saoul, Korea., Sep. 2011. Eiji Tanaka :
Orthodontic treatment for the acquired open bite associated osteoarthritis of temporomandibular joint,
2011 Taiwan Orthodontic Society Annaul Sections, Taipei, Taiwan., Aug. 2011. Akihiro Yasue, Naoko Yoneda, Teppei Watanabe and Eiji Tanaka :
Application of SIS3, a prospective drug, for wound repair acceleration,
89th IADR, San Diego, Mar. 2011. Shingo Kuroda, Rima Wazen, Karen Sellin, Eiji Tanaka, Pierre Moffatt and Antonio Nanci :
Full-length ameloblastin is not implicated in bone remodeling and repair.,
89th IADR, San Diego, Mar. 2011. A Nakajima, Y Ito, Eiji Tanaka, K Iwata, M Maeno, N Shimizu and C Shuler :
The functional role of TβR-II and IIIduring palatal fusion.,
89th IADR, San Diego, Mar. 2011. Shinya Horiuchi, Kenzo Asaoka, Shinji Fujihara, Akihiro Yasue and Eiji Tanaka :
Development of zinc-releasing apatite cement modified by zinc calcium phosphoate,
89th IADR, San Diego, Mar. 2011. Yuko Tomita, Shingo Kuroda, Tomoko Kataura, Shinji Fujihara and Eiji Tanaka :
Alveolar cleft severity in UCLP infants affects following maxillofacial growth,
89th IADR, San Diego, Mar. 2011. Shinji Fujihara, Tomoko Kataura, Tatsuya Nakamura, Kumiko Nagata, Shinya Horiuchi and Eiji Tanaka :
The effect of low-intensity pulsed ultrasound on maxillofacial bone healing,
89th IADR, San Diego, Mar. 2011. Tatsuya Nakamura, Shinji Fujihara and Eiji Tanaka :
Effects of LIPUS on Synovial Membrane under Inflammatory Condition,
89th IADR, San Diego, Mar. 2011. Kazuma Matsumoto, Naozumi Ishimaru, Yoshio Hayashi and Eiji Tanaka :
Analysis of osteoclast activation in the pathogenesis of rheumatoid arthritis,
International Joint Symposium: The University of Tokushima, Universitas Gadjah Mada, Niigata University, Denpasar, Bali, Dec. 2010. Kazuna Takahara, R Murahashi, K Mori, Seiichi Oyadomari and Eiji Tanaka :
ATF6 links endoplasmic reticulum (ER) stress to intestinal inflammation in mice.,
International Joint Symposium: The University of Tokushima, Universitas Gadjah Mada, Niigata University, Denpasar, Bali, Dec. 2010. Kyoko Ishimoto, Takeo Iwata, Katsuhiko Yoshimoto and Eiji Tanaka :
Functional analysis of a novel adipokine, D-dopachrome tautomerase, in preadipocytes.,
International Joint Symposium: The University of Tokushima, Universitas Gadjah Mada, Niigata University, Denpasar, Bali, Dec. 2010. Keiichiro Watanabe, Masahiro Abe, Cui Qu, Kawatani Makoto, Masahiro Hiasa, Nakano Ayako, Jinno Tadashi, Harada Takeshi, Shiroh Fujii, Shingen Nakamura, Miki Hirokazu, Kumiko Kagawa, Kyoko Takeuchi, Shuji Ozaki, Eiji Tanaka, Osada Hiroyuki and Toshio Matsumoto :
An Acidic Mileu Created In Myeloma-Osteoclast Interaction Enhances Tumor Growth, but Triggers Anti-Myeloma Activity of Reveromycin A, a Novel Anti-Resorptive Agent,
52th American Society of Hematology, Orlando, Dec. 2010. Eiji Tanaka :
Orthodontic treatment for the acquired open bite associated osteoarthritis of temporomandibular joint (TMJ),
Dentisphere (Dentistry Update and Scientific Atmosphere), Surabaya, Indonesia., Oct. 2010. Keiichiro Watanabe, Masahiro Abe, Cui Qu, Kawatani Makoto, Masahiro Hiasa, Nakano Ayako, Jinno Tadashi, Harada Takeshi, Shiroh Fujii, Shingen Nakamura, Miki Hirokazu, Kumiko Kagawa, Kyoko Takeuchi, Shuji Ozaki, Eiji Tanaka, Osada Hiroyuki and Toshio Matsumoto :
A Novel Anti-resorptive Agent, Reveromycin A, Ameliorates Bone Destruction and Tumor Growth in Myeloma,
ASBMR 2010 Annual Meeting, Toronto, Oct. 2010. Masahiro Hiasa, Masahiro Abe, nakano ayako, oda aska, amo hiroe, Keiichiro Watanabe, Shingen Nakamura, miki hirokazu, Kyoko Takeuchi, Kumiko Kagawa, Shuji Ozaki, Eiji Tanaka, Kenzo Asaoka and Toshio Matsumoto :
Bone Marrow Stromal Cells Suppress TACE-mediated M-CSFR and RANK Shedding to Facilitate Osteoclastogenesis and Suppress DC Differentiation from Monocytes.,
ASBMR 2010 Annual Meeting, Toronto, Oct. 2010. Keiichiro Watanabe, Masahiro Abe, Cui Qu, Kawatani Makoto, Masahiro Hiasa, Nakano Ayako, Jinno Tadashi, Harada Takeshi, Shiroh Fujii, Shingen Nakamura, Miki Hirokazu, Kumiko Kagawa, Kyoko Takeuchi, Shuji Ozaki, Eiji Tanaka, Osada Hiroyuki and Toshio Matsumoto :
The novel anti-resorptive agent reveromycin A ameliorates bone destruction and tumor growth in myeloma,
10th International Conference Cancer-induced Bone Disease, Sheffield (United Kingdom), Sep. 2010. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Ritsuko 徳永律子 Oura, Eiji Tanaka and Yoshio Hayashi :
Fas-independent apoptosis of T cells via DCs controls autoimmune arthritis,
international immunology, Vol.22, No.1, 113, Aug. 2010. Ritsuko 徳永律子 Oura, Naozumi Ishimaru, Rieko Arakaki, Takashi Izawa, Akiko Yamada, Kazuma Matsumoto, Eiji Tanaka and Yoshio Hayashi :
Rapid T cell death via interaction with CD11b+ macrophages in Fas-deficient host,
international immunology, Vol.22, No.1, 116, Aug. 2010. Teppei Watanabe, Akihiro Yasue, Shinji Fujihara and Eiji Tanaka :
Periostin Up-regulates MMPs via ERK pathway in Periodontal Ligament Cells,
88th IADR, Barcelona, Jul. 2010. Ritsuko 徳永律子 Oura, Naozumi Ishimaru, Eiji Tanaka and Yoshio Hayashi :
Rapid peripheral T cell death in Fas-deficient mice,
88th IADR, Barcelona, Jul. 2010. Toshihiro Inubushi, EB Rego, A Kawazoe, Kotaro Tanimoto, Mutsumi Miyauchi, Eiji Tanaka, Takashi Takata and Kazuo Tanne :
Low-intensity ultrasound enhanced cementum regeneration in vitro and in vivo,
88th IADR, Barcelona, Jul. 2010. Ohnuki Y, Saika Nakamura, Nobuhiko Kawai, Eiji Tanaka and Saeki Y :
Effects of Clenbuterol on Daily Activity in Rat Masseter Muscle,
88th IADR, Barcelona, Jul. 2010. Nao Kinouchi, Emi Kawakami, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Atelocollagen-mediated Systemic Administration of Myostatin siRNA Improves Muscular Dystrophy,
88th IADR, Barcelona, Jul. 2010. Saika Nakamura, Nobuhiko Kawai, R Sano, JAM Korfage, GEJ Langenbach, Y Ohnuki, Y Saeki, Kazuo Tanne and Eiji Tanaka :
Aging-associated Changes in Fiber Characteristics in the Rat Masticatory Muscles,
88th IADR, Barcelona, Jul. 2010. Emi Kawakami, Nao Kinouchi, Adachi Taro, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Special Processed Collagen-mediated Application of Myostatin-siRNA for Muscular Atrophy Diseases,
88th IADR, Barcelona, Jul. 2010. Masahiro Hiasa, Masahiro Abe, Eiji Tanaka, Kenzo Asaoka and Toshio Matsumoto :
Stroma inhibit DC differentiation through the suppression of M-CSFR shedding,
88th IADR, Barcelona, Jul. 2010. Eiji Tanaka, Shingo Kuroda, Nobuhiko Kawai, Takashi Izawa, Toshihiro Inubushi and Kotaro Tanimoto :
Sensitivity of loading direction on dynamic shear behavior of condylar cartilage-on-bone,
16th US National Congress of Theoretical and Applied Mechanics, PA, USA, Jun. 2010. Masahiro Hiasa, Masahiro Abe, I Endo, A Nakano, Shuji Ozaki, Eiji Tanaka, Kenzo Asaoka and Toshio Matsumoto :
Myeloma-bone marrow stromal cell interaction enhances osteoclastogenesis and suppresses dendritic cell differentiation from monocytes,
14th International Congress of Endocrinology, Kyoto, Mar. 2010. Eiji Tanaka :
Orthodontics and it's relation to TMJ,
University of Airlangga, Surabaya, Inodonesia., Mar. 2010. Eiji Tanaka :
Temporomandibular joint disorders: Etiology, Diagnosis, and Treatment. Management of pain in dentisty,
Management of pain in dentisty, Makasar, Indonesia., Mar. 2010. Eiji Tanaka :
Development of biomechanical assessment system for TMJ loading and its application to orthodontic treatment,
Taiwan Orthodontic Society 2010, Taipei, Feb. 2010. Emi Kawakami, Nao Kinouchi, Yutaka Osawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Strategic study of atelocollagen-mediated application of mystatin-targeting siRNA for therapeutic use for muscular atrophy diseases,
QOL International Congress, Niigata, Feb. 2010. Eiji Tanaka :
Biomechanical and clinical assessment for jaw movement and the related TMJ loading in patients with TMDs,
Baiturrahmah University Dentistry Faculty, Padang, Indonesia, Nov. 2009. Eiji Tanaka :
The use of ultrasound in dentistry,
The 4th Regional Dental Meeting and Exhibition, Medan, Indonesia., Nov. 2009. Masahiro Hiasa, Masahiro Abe, A Nakano, Kyoko Takeuchi, K Watanabe, Kumiko Kagawa, Ken-ichiro Yata, Kenzo Asaoka, Eiji Tanaka and Toshio Matsumoto :
Bone marrow stromal cells inhibit dendritic cell differentiation and facilitate osteoclastogenesis in myeloma through the suppression of M-CSF receptor shedding in monocytes,
第26回内藤コンファレンス, Nov. 2009. Saika Nakamura, Nobuhiko Kawai, Y Kitayama, M Watanabe, Kazuo Tanne and Eiji Tanaka :
Masticatory muscle activity in a rat model of Parkinson's disease,
2nd Meeting of IADR PAPF / 1st Meeting of IADR APR, Wuhan, Sep. 2009. Teppei Watanabe, Akihiro Yasue, Shinji Fujihara and Eiji Tanaka :
Periostin negatively regulates osteoblastic differentiation in human periodontal ligament cells,
2nd Meeting of IADR PAPF / 1st Meeting of IADR APR, Wuhan, Sep. 2009. Eiji Tanaka, R Sano, JAM Korfage, Nobuhiko Kawai, Saika Nakamura, Shinya Horiuchi, Shingo Kuroda and GEL Langenbach :
Fiber heterogeneity in the rat masseter and temporalis muscles,
87th IADR, Miami, Apr. 2009. Shinya Horiuchi, Kenzo Asaoka, Takashi Izawa, Shinji Fujihara, Nao Kinouchi, Shingo Kuroda and Eiji Tanaka :
Development of novel bioceramic by modification of zinc phosphate cement,
87th IADR, Miami, Apr. 2009. C Nishio, M Ueki, N Tanaka, Y-Y Lin, K Tanimoto, Eiji Tanaka, A Moraes Mendes de, C Quintao and Kazuo Tanne :
Comparison of response to mechanical loading between two articular cartilages,
86th IADR, Toronto, Jul. 2008. EB Rego, Eiji Tanaka, T Inubushi, M Miyauchi, Takashi Takata, A Ohta, H Okada and Kazuo Tanne :
PGE2 production in cementoblasts and PDL cells by ultrasound stimulation,
86th IADR, Toronto, Jul. 2008. Nao Kinouchi, Yutaka Osawa, Naozumi Ishimaru, Yoshio Hayashi, Keiji Moriyama, Sumihare Noji and Eiji Tanaka :
Atelocollagen-mediated lapplications of myostatin-targeting siRNA increase skeletal muscle mass,
86th IADR, Toronto, Jul. 2008. 髙田一樹, 渡邉佳一郎, 堀内信也, 松木佑太, 安陪晋, 梅田雛代, 前田直樹, 田中栄二 :
CT値を用いた特発性下顎頭吸収の鑑別診断の可能性の検討,
第37回日本顎関節学会総会・学術大会, 2024年7月. 和田涼平, 武川恵美, 堀内信也, 関根一光, 田中栄二, 浜田賢一 :
レジン添加型グラスアイオノマーセメントの接着強度に印加電圧の変動が与える影響,
第82回日本歯科理工学会学術講演会, 2024年4月.

(キーワード): スマートセメント / レジンセメント / 接着 / 剥離

内海雄太, 川野沙織, 松木優承, 渡邉佳一郎, 大毛健一郎, 伊田百美香, 米倉和秀, 田中栄二, 保坂啓一 :
上顎側切歯1歯欠損に対して，デジタルワークフローを活用したインジェクションテクニックにより，2層のダイレクトボンディングブリッジを行った審美修復症例,
日本歯科審美学会, 2023年12月. 日浅雅博, 堀内信也, 渡邉佳一郎, 田中栄二 :
歯科矯正用アンカースクリューの初期安定性に対する皮質骨厚の影響,
第3回歯科矯正用アンカースクリュー研究会学術大会, 2023年11月. 田中栄二 :
下顎偏位に起因した顔面非対称症における咬合平面傾斜改善が術後安定性に及ぼす影響,
第41回日本頭蓋顎顔面外科学会，シンポジウム, 2023年11月. 花輪茂己, 関根一光, キムイエウン, 浜田賢一, 田中栄二 :
ボールミリング法で改質したリン酸カルシウムセメントへのポロキサマー・コラーゲン・クエン酸ゲルの添加効果,
第61回日本人工臓器学会大会, 2023年11月. 峯田一秀, 吉永薫, 渡邉佳一郎, 山崎裕行, 美馬俊介, 安倍吉郎, 田中栄二, 橋本一郎 :
ファーラー法による口蓋形成の術直前後と3か月後のにおける硬口蓋の形態評価,
第41回日本頭蓋顎顔面外科学会学術集会, 2023年11月. 吉永薫, 泰江章博, 田中栄二 :
Wnt10aおよびWnt10bのダブル変異が歯の発生に及ぼす影響,
第82回日本矯正歯科学会学術大会抄録集, 156, 2023年11月. 中上絵美子, 寺町順平, 日浅雅博, 清水宗, 比嘉佳基, 田中茉里子, 金秀河, 中川宗純, 田中栄二, 安倍正博 :
プロテアソーム阻害薬による骨髄腫骨病変部における骨形成のメカニズム,
第82回日本矯正歯科学会学術大会抄録集, 192, 2023年11月. 比嘉佳基, 日浅雅博, 中川宗純, 金秀河, 田中茉里子, 中上絵美子, 清水宗, 天眞寛文, 田中栄二, 安倍正博 :
KEAP1-NRF2軸を介した脂肪細胞分化と骨芽細胞分化の制御機構,
第82回日本矯正歯科学会学術大会抄録集, 194, 2023年11月. 峰田眞伍, 中嶋昭, 中野泰児, 納村泰弘, 田中栄二, 米山隆之, 本吉満 :
スロット形状の異なるリンガルブラケットにおけるサードオーダーベンド付与時のモーメント値の比較,
第82回日本矯正歯科学会学術大会抄録集, 201, 2023年11月. 高木豊明, 新宅優子, 相川友直, 清水宗, 田中栄二 :
外科的矯正治療を適用した特発性下顎頭吸収を伴う骨格性II級症例,
第82回日本矯正歯科学会学術大会抄録集, 255, 2023年11月. 渡邉佳一郎, 竹谷淳志, 芳賀昭弘, 田中栄二 :
仮想コーンビームCT(CBCT)とAI技術を用いたCBCT画像の歯の高精度オートセグメンテーション手法の開発,
第82回日本矯正歯科学会学術大会抄録集, 151, 2023年11月. 堀内信也, 中上絵美子, 渡邉佳一郎, 日浅雅博, 田中栄二 :
顎間関係を判断するAIにおける判定根拠に関する検討,
第82回日本矯正歯科学会学術大会抄録集, 208, 2023年11月. 森仁志, 森浩喜, 管野貴浩, 田中栄二 :
下顎枝矢状分割術とオトガイ形成術にて下顎骨前方移動を施行した著しい下顎後退症患者の長期経過観察,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 117-118, 2023年8月.

(キーワード): 顎後退症(合併症, 外科的療法, 予後) / 顎前突症(合併症, 外科的療法, 予後) / 統計 (statistics) / 下顎枝矢状分割術 / オトガイ形成術 / ヒト; 成人(19∼44); 女; 歯学

金城聡一郎, 塩屋園玲子, 吉永薫, 中上絵美子, 渡邉佳一郎, 日浅雅博, 田中栄二 :
上顎骨前方部延長術を行った口唇口蓋裂患者2症例の術後評価,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 114-115, 2023年8月.

(キーワード): 顎の奇形(外科的療法) / 歯科矯正治療 / 統計 (statistics) / 病院歯科診療部門 / 顎矯正手術 / ヒト; 男; 女; 歯学

花輪茂己, 日浅雅博, 岩浅亮彦, 渡邉佳一郎, 天眞寛文, 木内奈央, 堀内信也, 田中栄二 :
上顎左側第二小臼歯先天性欠如を伴う片側性唇顎口蓋裂患者に対して下顎左側第二小臼歯を移植した一症例,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 67-75, 2023年8月.

(要約): 口唇裂・口蓋裂患者では永久歯が先天性欠如する割合が高く,とくに複数歯が先天性欠如する症例の場合,マルチブラケット装置を用いた治療の際に咬合の確立に苦慮することは少なくない.今回,上顎左側側切歯および第二小臼歯の先天性欠如を伴う左側唇顎口蓋裂患者に対して,便宜抜去した下顎左側第二小臼歯を上顎左側第二小臼歯欠如部に移植し全顎的な矯正治療を行うことで良好な治療結果が得られたので報告する.初診時年齢0歳20日の女児で,左側唇顎口蓋裂を主訴に当院形成外科から紹介され来院した.12歳時,下顎歯列におけるarch length discrepancyの改善のために抜去した下顎左側第二小臼歯を上顎左側第二小臼歯欠如部へ移植した.12歳10ヵ月時,移植歯の歯根形成と根尖孔閉鎖が認められ,顎骨の成長がほぼ終了したため,二期治療としてマルチブラケット装置を用いて咬合の確立を図った.動的治療期間は5年0ヵ月で,1歯対2歯の緊密な咬合関係が獲得された.現在,保定後2年3ヵ月経過して安定した咬合を維持している.本症例では,便宜抜去した歯を移植することで,補綴処置を回避し,天然歯による緊密な咬合を獲得することができた.移植後2年経過した時点で歯根吸収は認めず,安定した経過をたどっている.しかしながら今後も長期的な観察が必要と考えられる.口唇裂・口蓋裂患者の歯の先天性欠如部位に対する治療法の一つとして歯の移植が有用であることが示唆された.(著者抄録)
(キーワード): パノラマX線撮影法 X線診断 *自家移植下顎骨歯根吸収(合併症,X線診断,外科的療法) *上顎疾患(合併症,外科的療法,診断) *小臼歯(移植) 頭部計測法歯(移植) *無歯症(合併症,外科的療法,診断) 歯科矯正維持装置歯科矯正用ブラケット *唇顎口蓋裂(合併症,外科的療法,診断) ヒト新生児女歯学

田中茉里子, 堀内信也, 日浅雅博, 渡邉佳一郎, 岩浅亮彦, 田中栄二 :
術後に顎関節に疼痛を訴えた下顎骨左方偏位を伴う骨格性上顎前突症例,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 77-86, 2023年8月.

(要約): 顎偏位を伴う骨格性上顎前突患者に対し,咬合平面の傾斜と下顎骨左方偏位および後退の改善を目的として上下顎同時移動術を施行し,術後に顎関節の変調をきたした症例を経験したので報告する.初診時25歳9ヵ月の女性で,顔面の非対称と上顎前突を主訴に来院した.顔面正中に対して上顎歯列正中は一致し,下顎歯列正中は6.0mm左方に偏位していた.咬合平面は2.0°左上がりに傾斜し,左側下顎枝は右側に比べ短かった.Overjetは8.5mm,overbiteは2.5mmであった.咬合平面の傾斜,下顎の左方偏位と後退を改善するため,上顎Le Fort I型骨切り術および下顎枝矢状骨切り術を施行した.顎骨の移動量については上顎右側臼歯部で5.5mmの圧下および左側臼歯部で1.5mmの圧下を計画した.下顎は右側臼歯部で4.0mmの後方移動および左側臼歯部で5.0mmの前方移動を計画した.術後,左側顎関節の疼痛を訴えたため,II級ゴムと上下顎同時移動術に用いたセカンドスプリントから移行した下顎前方整位型スプリントを使用したところ,関節部の疼痛は軽減した.段階的にII級ゴムとスプリントの装着時間を短くした結果,下顎の後退が観察され,overjetが増加傾向を示したため,歯科矯正用アンカースクリューを固定源として使用した上顎歯列の遠心移動を行った.術後2年8ヵ月経過時に,良好な咬合が獲得され下顎位も安定したため保定へと移行した.現在保定後5年4ヵ月経過して,緊密な咬合状態が保たれている.下顎の前方移動を伴う外科的矯正治療は,顎関節に不調をきたすことも多く,術後長期にわたる経過観察と,治療変化に対応し得る余地を残した治療計画を勘案する必要性が示唆された.(著者抄録)
(キーワード): パノラマX線撮影法 X線診断 *下顎骨 *顎関節疾患(病因,診断,治療) 顎の奇形(合併症,外科的療法,診断) *顎前突症(合併症,外科的療法,診断) 歯科矯正ワイヤー MRI *術後痛(診断,治療) 頭部計測法 *関節痛(病因,診断,治療) オクルーザルスプリント LeFort骨切り術歯科矯正用ブラケット下顎枝矢状分割術歯科矯正用固定源埋込みエッジワイズ法矯正的遠心移動ヘッドギアヒト成人(19∼44) 女歯学

中川宗純, 日浅雅博, 花輪茂己, 金秀河, 比嘉佳基, 松木佑太, 堀内信也, 田中栄二 :
上顎骨前方部延長術を行った口唇口蓋裂患者2症例の術後評価,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 112-113, 2023年8月.

(キーワード): *口蓋裂(外科的療法,診断) *口唇裂(外科的療法,診断) *骨延長法 *上顎骨治療成績ヒト歯学

西田真衣, 堀内信也, 清水宗, 田中茉里子, 和田涼平, 谷本幸多朗, 渡邉佳一郎, 田中栄二 :
徳島大学病院矯正歯科における成長ホルモン投与矯正患者に関する実態調査,
中·四国矯正歯科学会雑誌, Vol.35, No.1, 115, 2023年8月.

(キーワード): *成長ホルモン(治療的利用) 外来患者 *歯科矯正治療 *病院歯科診療部門実態調査ヒト男女歯学

金秀河, 寺町順平, 日浅雅博, 天眞寛文, 中上絵美子, 田中茉里子, 中川宗純, 遠藤逸朗, 原田武志, 田中栄二, 安倍正博 :
骨形成誘導による骨髄腫排他的ニッチ形成の分子機序の探索,
日本骨代謝学会学術集会プログラム抄録集, 173, 2023年7月. 梅田雛代, 増田多衣子, 安陪晋, 前田直樹, 松木祐太, 岩浅亮彦, 堀内信也, 田中栄二 :
下顎頭の器質的変化を伴う顎関節疾患患者の下顎頭の形態学的特徴,
日本顎関節学会雑誌, Vol.35, No.36, 120, 2023年7月. 田中栄二 :
特発性下顎頭吸収に関する基礎知識,
中·四国矯正歯科学会雑誌, 2023年7月. 松木佑太, 岩浅亮彦, 堀内信也, 前田直樹, 田中栄二 :
特発性下顎頭吸収に起因する著しい前歯部開咬症例に対する歯科矯正学的アプローチ,
日本顎関節学会雑誌, Vol.35, No.Suppl., 112, 2023年7月.

(キーワード): *下顎頭 *骨吸収(合併症,X線診断,治療) *歯科矯正治療 *開咬(病因,X線診断,治療) *前歯ヒト成人(19∼44) 女歯学

渡邉佳一郎, 中上絵美子, 鎌田久美子, 髙丸菜都美, 栗尾奈愛, 田中栄二 :
3DシミュレーションとCAD/CAMスプリントを用いて上下顎移動術を施行した顎偏位を伴う骨格性下顎前突の1例,
日本顎変形症学会雑誌, Vol.33, No.2, 174, 2023年5月.

(キーワード): 顎前突症(合併症, 外科的療法, 診断) / スプリント, 不正咬合-アングルIII級(合併症, 外科的療法, 診断) / コンピュータ支援設計, *コンピュータシミュレーション / 三次元イメージング, *顎矯正手術 / ヒト; 成人(19∼44); 女; 歯学

渡邉佳一郎, 吉永薫, 金秀河, 花輪茂己, 田中茉里子, 山崎裕行, 峯田一秀, 堀内信也, 橋本一郎, 田中栄二 :
中間顎誘導型NAMの早期装着により,短期間で中間顎の整位を行った両側性唇顎口蓋裂の3,
日本口蓋裂学会雑誌, Vol.48, No.2, 133, 2023年5月.

(キーワード): 唇顎口蓋裂(治療) / 術前顎矯正治療 / 統計 (statistics) / ヒト; 新生児; 男; 女; 歯学

和田涼平, 渡邉佳一郎, 吉永薫, 金秀河, 花輪茂己, 田中茉里子, 坂本幸, 島田亜紀, 近藤英司, 北村尚正, 山崎裕行, 峯田一秀, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における過去10年間の口唇裂・口蓋裂患者に関する臨床統計調査,
日本口蓋裂学会雑誌, Vol.48, No.2, 200, 2023年5月.

(キーワード): 口蓋裂 / 統計 (statistics) / 大学病院 / ヒト; 男; 女; 歯学

近藤英司, 坂本幸, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討,
第47回日本口蓋裂学会, 2023年5月. 坂本幸, 近藤英司, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の新生児聴覚スクリーニング結果と滲出性中耳炎罹患率,
日本口蓋裂学会雑誌, Vol.48, No.2, 153, 2023年4月.

(キーワード): *口蓋裂(合併症) *新生児スクリーニング *中耳炎-滲出性(診断,合併症) 発生率大学病院 *聴覚検査ヒト乳児(1∼23ヶ月) 幼児(2∼5) 男女歯学

近藤英司, 坂本幸, 島田亜紀, 吉永薫, 北村尚正, 山崎裕行, 峯田一秀, 渡邉佳一郎, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討,
日本口蓋裂学会雑誌, Vol.48, No.2, 154, 2023年4月.

(キーワード): *口蓋裂(合併症) *中耳炎-滲出性(外科的療法,合併症) *中耳換気大学病院結果再現性ヒト乳児(1∼23ヶ月) 幼児(2∼5) 小児(6∼12) 青年期(13∼18) 男女歯学

峯田一秀, 金秀河, 渡邉佳一郎, 山崎裕行, 山下雄太郎, 安倍吉郎, 田中栄二, 橋本一郎 :
徳島大学病院口唇口蓋裂センター設立前後での患者動向の検討,
第40回日本頭蓋顎顔面外科学会学術集会, 2022年11月. 花輪茂己, 関根一光, キムイエウン, 浜田賢一, 田中栄二 :
in vivo下および疑似in vivo環境下で結晶化させた改質型リン酸カルシウムセメントの生体内硬化挙動に関する評価と解析,
第60回日本人工臓器学会大会, Vol.51, No.2, S-181, 2022年11月. 渡邉佳一郎, 天眞寛文, 中上絵美子, 塩屋園玲子, 田中栄二 :
上顎歯列の全体的な圧下を行い骨格的な改善を図った，ガミースマイルを伴う成人骨格性上顎前突症例,
第81回日本矯正歯科学会学術大会, 2022年10月. 比嘉佳基, 日浅雅博, 金秀河, 田中茉里子, 中上絵美子, 清水宗, 谷本幸多朗, 天眞寛文, 田中栄二, 安倍正博 :
キサンチンオキシダーゼ阻害薬febuxostatはKEAP1-NRF2軸を介し脂肪細胞分化と骨芽細胞分化を制御する,
第81回日本矯正歯科学会学術大会, 2022年10月. 清水宗, 寺町順平, 日浅雅博, 天眞寛文, 比嘉佳基, 中上絵美子, 安倍正博, 田中栄二 :
骨髄腫細胞の生存・増殖におけるTAK1-CIP2A経路の重要な役割,
第81回日本矯正歯科学会学術大会, 2022年10月. 松木佑太, 佐藤博子, 梶本昇, 堀内信也, 関根一光, 田中栄二 :
通電によるレジン添加型グラスアイオノマーセメントのせん断強度低下に塩化ナトリウム溶液浸漬が与える影響,
第81回日本矯正歯科学会学術大会, 2022年10月. 岩浅亮彦, 比嘉佳基, 中上絵美子, 吉永薫, 清水宗, 松木佑太, 谷本幸多朗, 渡邉佳一郎, 日浅雅博, 堀内信也, 田中栄二 :
特発性下顎頭吸収を呈する矯正患者の下顎頭の形態学的特徴,
第81回日本矯正歯科学会学術大会, 2022年10月. 中上絵美子, 天眞寛文, 日浅雅博, 寺町順平, 原田武志, 井上雄介, 谷本幸多朗, 清水宗, 比嘉佳基, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
プロテアソーム阻害薬による骨髄腫骨病変部選択的骨形成誘導活性の検討,
第40回日本骨代謝学会学術集会, 141, 2022年7月. 比嘉佳基, 日浅雅博, 天眞寛文, 寺町順平, 原田武志, 小田明日香, 遠藤逸朗, 松本俊夫, 田中栄二, 安倍正博 :
キサンチンオキシダーゼ(XO)阻害薬febuxostatによる脂肪細胞分化と骨芽細胞分化の制御機構,
第40回日本骨代謝学会学術集会, 2022年7月. 田中茉里子, 日浅雅博, 谷本幸多朗, 天眞寛文, 清水宗, 比嘉佳基, 中上絵美子, 金秀河, 寺町順平, 原田武志, 中村信元, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
不動は骨髄腫骨病変部DPP-4発現増加と骨髄腫の腫瘍進展・髄外播種を加速させる,
第40回日本骨代謝学会学術集会, 2022年7月. 原田武志, 天眞寛文, 井上雄介, 住谷龍平, 中上絵美子, 寺町順平, 日浅雅博, 田中栄二, 松本俊夫, 安倍正博 :
破骨細胞によるSLAMF7の産生と骨髄腫関連骨病変に対するSLAMF7標的療法の開発,
第40回日本骨代謝学会学術集会, 2022年7月. 大瀧大地, 赤松沙友里, 後藤田茉子, 花輪茂己, 田中茉里子, 佐藤博子, 田中栄二 :
徳島大学病院矯正歯科に来院した不正咬合患者における顎関節症の実態調査,
中·四国矯正歯科学会雑誌, 2022年7月. 中上絵美子, 渡邉佳一郎, 天眞寛文, 吉永薫, 松木佑太, 日浅雅博, 堀内信也, 田中栄二 :
実現可能な下顎臼歯遠心移動の予測に必要な決定因子の特定,
中·四国矯正歯科学会雑誌, 2022年7月. 坂巻拓馬, 渡邉佳一郎, 岩浅亮彦, 金秀河, 田中栄二 :
歯科矯正用アンカースクリューの初期安定性に対する皮質骨厚の影響,
中·四国矯正歯科学会雑誌, 2022年7月. 岩浅亮彦, 比嘉佳基, 中上絵美子, 清水宗, 中村竜也, 藤原慎視, 堀内信也, 田中栄二 :
上顎埋伏犬歯に対して開窓牽引を行った叢生症例-長期保定観察例-,
中·四国矯正歯科学会雑誌, 2022年7月.

(キーワード): 臨床矯正歯科学 (clinical orthodontics)

田中茉里子, 堀内信也, 日浅雅博, 渡邉佳一郎, 岩浅亮彦, 髙丸菜都美, 永井宏和, 宮本洋二, 田中栄二 :
術後に顎関節に変調をきたした顎偏位を伴う骨格性上顎前突症例,
第32回日本顎変形症学会総会・学術大会, Vol.32, No.2, 171, 2022年6月. 花輪茂己, 日浅雅博, 岩浅亮彦, 渡邉佳一郎, 天眞寛文, 木内奈央, 堀内信也, 田中栄二 :
上顎左側第二小臼歯先天欠損を伴う片側性唇顎口蓋裂患者に対して下顎左側第二小臼歯を移植した一症例,
日本口蓋裂学会雑誌, Vol.47, No.2, 146, 2022年5月. 金秀河, 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
徳島大学病院における口唇口蓋裂センター設立前後での患者動向の変化金秀河(徳島大学大学院口腔科学教育部口腔顎顔面矯正学分野), 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩崎智憲, 橋本一郎, 田中栄二日本口蓋裂学会雑誌(0386-5185)47巻2号 Page135(2022.04),
日本口蓋裂学会雑誌, Vol.47, No.2, 135, 2022年5月. 比嘉佳基, 日浅雅博, 天眞寛文, 谷本幸多朗, 清水宗, 寺町順平, 原田武志, 小田明日香, 遠藤逸朗, 松本俊夫, 田中栄二, 安倍正博 :
骨髄腫骨髄微小環境の変容におけるキサンチンオキシダーゼ-ROS経路の重要な役割,
International Journal of Myeloma, Vol.12, No.3, 149, 2022年5月. 中上絵美子, 天眞寛文, 寺町順平, 日浅雅博, 原田武志, 谷本幸多朗, 清水宗, 比嘉佳基, 住谷龍平, 丸橋朋子, 大浦雅博, 曽我部公子, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 安倍正博 :
プロテアソーム阻害薬のパルス投与の骨代謝への影響,
International Journal of Myeloma, Vol.12, No.3, 152, 2022年5月.

(キーワード): 骨髄腫-多発性(薬物療法,病理学) / 骨組織リモデリング / パルス療法(薬物療法) / Proteasome Inhibitors(治療的利用,薬理学) / ヒト (Homo sapiens)

渡邉佳一郎, 天眞寛文, 吉永薫, 中上絵美子, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 日浅雅博, 堀内信也, 岩﨑智憲, 橋本一郎, 田中栄二 :
Pre-epiglottic baton plateによる保存的治療で重度気道閉塞の改善がみられたPierre Robin Sequenceの1例,
日本口蓋裂学会雑誌, Vol.47, No.2, 116, 2022年4月.

(キーワード): *Pierre Robin症候群(合併症) *気道閉塞(合併症,診断,予後) 呼吸障害(病因,予後) *保存的療法哺乳障害(病因,予後) ヒト新生児男歯学

大瀧大地, 赤松沙友里, 後藤田茉子, 佐藤博子, 田中栄二 :
徳島大学病院矯正歯科に来院した不正咬合患者の顎関節症状に関する臨床統計調査,
四国歯学会雑誌, 2022年3月. 田中栄二 :
徳島大学病院矯正歯科における臨床と研究の特色について,
東北矯正歯科学会第15回秋期セミナー, 2021年11月. 坂巻拓馬, 岩浅亮彦, 夏霖泽, Yao Liu, 加納史也, 山本朗仁, 田中栄二 :
変形性顎関節症に対する低出力超音波パルスの治療効果,
日本矯正歯科学会雑誌, 2021年11月. 渡邉佳一郎, 荒井大志, 篠原丈裕, 岩浅亮彦, 田中栄二 :
歯科矯正用アンカースクリューを用いて咬合の構築を行った全顎的な鋏状咬合と過蓋咬合を伴う重度歯槽性上顎前突症例,
日本矯正歯科学会雑誌, 2021年11月. 渡邉佳一郎, Bobby Mitchell, 平井雄三, Do-gyoon Kim, 出口徹, 田中栄二 :
新しいネジ山形状を有する歯科矯正用アンカースクリューの機械的安定性に関する研究,
日本矯正歯科学会雑誌, 2021年11月. 山田尋士, 沢田正樹, 東野正明, 安陪晋, 田中栄二 :
日本人小学生のアデノイドおよび口蓋扁桃の形態的特徴に関する縦断的調査,
日本矯正歯科学会雑誌, 2021年11月. 細木秀彦, 前田直樹, 松本文博, 田中栄二, 松香芳三 :
顎関節症患者のMRI検査のキャンセルに関する検討,
日本顎関節学会雑誌, Vol.33, 96, 2021年10月. 天眞寛文, 渡邉佳一郎, 中上絵美子, 田中栄二 :
歯科矯正用アンカースクリューを用いた積極的な臼歯圧下により治療を行なった成人骨格性開咬症例,
第80回日本矯正歯科学会学術大会, 2021年10月. Sou Shimizu, Jumpei Teramachi, Takeshi Harada, 小田明日香, Hirofumi Tenshin, Masahiro Hiasa, Kotaro Tanimoto, Yoshiki Higa, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
The critical roles of the TAK1-CIP2A axis in MM cell growth and survival and osteoclastogensis,
第83回日本血液学会学術集会, BPA-3-3, Sep. 2021. Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Takeshi Harada, 小田明日香, 大浦雅弘, Kimiko Sogabe, Itsuro Endo, Toshio Matsumoto, Masahiro Abe and Eiji Tanaka :
Critical roles of the XO-ROS axis in the pathology of bone loss in myeloma,
第83回日本血液学会学術集会, BPA-3-4, Sep. 2021. Hirofumi Tenshin, 寺町順平日浅雅博小田明日香原田武志, Masahiro Hiasa, 小田明日香, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Kotaro Tanimoto, Sou Shimizu, Yoshiki Higa, Eiji Tanaka, Itsuro Endo, Toshio Matsumoto and Masahiro Abe :
NLRP3 inflammasome aggravates osteoclastic bone destruction in myeloma,
日本血液学会学術集会83回 Page 83回 Page OS2-4B-4(2021.09), Sep. 2021. Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Takeshi Harada, 小田明日香, Masahiro Oura, Kimiko Sogabe, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka and Masahiro Abe :
Extraosseous dissemination of myeloma by mechanical unloading,
日本血液学会学術集会83回 Page 83回 Page OS2-11C-3(2021.09), Sep. 2021. 加納史也, LIU YAO, 橋本登, 松香芳三, 田中栄二, 山本朗仁 :
⻭髄幹細胞由来無⾎清培養上清は坐⾻神経結紮モデルマウスの神経障害性疼痛を改善する,
第63回歯科基礎医学会学術大会, 2021年9月.

(キーワード): 歯髄幹細胞 / 培養上清 / 神経障害性疼痛

佐藤博子, 堀内信也, 清水宗, 田中栄二 :
埋伏した巨大な上顎中切歯を伴う上顎前突症例,
中·四国矯正歯科学会雑誌, Vol.33, No.1, 86-87, 2021年8月.

(キーワード): *顎前突症(合併症,治療,予後) 過剰歯(合併症,外科的療法,予後) *上顎骨 *切歯抜歯 *埋伏歯(合併症,外科的療法,予後) 歯科矯正用ブラケットヘッドギアヒト小児(6∼12) 男歯学

岩浅亮彦, 渡邉佳一郎, 伊藤彩実, 塩屋園玲子, 坂巻拓馬, 比嘉佳基, 小笠原直子, 堀内信也, 田中栄二 :
Hemifacial microsomiaに対して矯正歯科治療単独で緊密な咬合を獲得した3症例,
中·四国矯正歯科学会雑誌, Vol.33, No.1, 86, 2021年7月. 平井雄三, 渡邉佳一郎, 中上絵美子, 吉村宗之, 天眞寛文, 日浅雅博, 田中栄二 :
歯科矯正用アンカースクリューおよび周囲骨の応力分布に及ぼす植立深さの影響:有限要素法による解析,
中·四国矯正歯科学会雑誌, Vol.33, No.1, 80, 2021年7月. 田中栄二 :
変形性顎関節症および特発性下顎頭吸収に対する歯科矯正学的対応,
第62回北海道矯正歯科学会学術大会, 2021年6月. 川合暢彦, 渡邊正彦, 柴田愛実, 堀内信也, 不島健持, 田中栄二 :
顎口腔機能分析による骨格性III級症例に対する外科的矯正治療と矯正単独治療のボーダーラインの検討,
日本顎変形症学会雑誌, Vol.31, No.2, 135, 2021年5月.

(キーワード): *口顎系, *骨格, *歯科矯正治療, *不正咬合-アングルIII級(治療, 外科的療法), *外科的歯科矯正治療

中上絵美子, 堀内信也, 渡邊正彦, 川合暢彦, 田中栄二 :
骨格性下顎前突症患者における口腔周囲機能に関する検討,
日本顎変形症学会雑誌, Vol.31, No.2, 143, 2021年5月.

(キーワード): *圧力 *顎前突症 *歯科生理学的現象 *口唇骨格舌 *下顎運動 *舌圧 *閉口動作ヒト青年期(13∼18) 成人(19∼44) 男女歯学

渡邉佳一郎, 天眞寛文, 峯田一秀, 石田創士, 吉永薫, 中上絵美子, 比嘉佳基, 宮嵜彩, 北村尚正, 坂本幸, 近藤英司, 島田亜紀, 日浅雅博, 堀内信也, 橋本一郎, 田中栄二 :
当院における口腔内スキャナーを活用した哺乳床早期装着のための取り組み,
日本口蓋裂学会雑誌, Vol.46, No.2, 123, 2021年4月.

(キーワード): 口蓋裂口唇裂 *歯科用機器 *母乳栄養ヒト乳児(1∼23ヶ月) 歯学

夏霖泽, 加納史也, 橋本登, 小笠原直子, LIU YAO, 田中栄二, 山本朗仁 :
:Analysis of the Therapeutic Mechanisms of SHED-CM for Experimentally Induced Temporomandibular Joint Osteoarthritis in Mice.,
四国歯学会雑誌, 2021年3月. 清水宗, 寺町順平, 原田武志, 小田明日香, 天眞寛文, 日浅雅博, 谷本幸多朗, 比嘉佳基, 田中栄二, 松本俊夫, 安倍正博 :
骨髄腫細胞のPP2A阻害因子CIP2A発現誘導を介するTAK1活性化増強機構,
日本骨代謝学会学術集会プログラム抄録集, 149, 2020年10月. 谷本幸多朗, 日浅雅博, 天眞寛文, ASHTAR MOHANNAD, 清水宗, 比嘉佳基, 寺町順平, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
不動は骨吸収と骨髄腫進展を促進させる,
日本骨代謝学会学術集会プログラム抄録集, 149, 2020年10月. 天眞寛文, ASHTAR MOHANNAD, 寺町順平, 日浅雅博, 谷本幸多朗, 清水宗, 比嘉佳基, 原田武志, 大浦雅博, 曽我部公子, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
抗腫瘍薬が誘導するROSは破骨細胞分化を促進する:Xanthine oxidase阻害剤febuxostatの治療効果．,
日本骨代謝学会学術集会プログラム抄録集, 148, 2020年10月. 堀内信也, 齋藤早紀, 中上絵美子, 渡邊正彦, 川合暢彦, 田中栄二 :
AIにて考察する最大口唇圧と顔面形態との関連性について,
日本矯正歯科学会雑誌, 2020年10月. Hirofumi Tenshin, アシテルモハナッド, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Sou Shimizu, 比嘉佳基, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
抗腫瘍薬が誘導するROSは破骨細胞分化を促進する Xanthine oxidase阻害剤febuxostatの治療効果,
The Annual Meeting of the Japanese Society for Bone and Mineral Research Program & Abstracts, 148, Oct. 2020.

(キーワード): Xanthine Oxidase(拮抗物質・阻害物質) / 活性酸素 (reactive oxygen species) / 抗腫瘍剤(毒性・副作用) / 骨吸収(化学的誘発,薬物療法,実験的) / 細胞分化 (cell differentiation) / 破骨細胞 (osteoclast) / 破骨細胞分化因子 / Febuxostat(治療的利用) / RAW264.7細胞 / マウス / 動物 (animal)

加納史也, 小笠原直子, 橋本登, 森浩喜, 宮嵜彩, 岩本勉, 田中栄二, 山本朗仁 :
歯髄幹細胞由来無血清培養上清を用いた変形性顎関節症の治療法開発,
第62回歯科基礎医学会学術大会, 2020年9月.

(キーワード): 変形性顎関節症 / 乳歯歯髄幹細胞 / 乳歯歯髄幹細胞由来培養上清

加納史也, LIU YAO, 橋本登, 松香芳三, 田中栄二, 山本朗仁 :
歯髄幹細胞由来無血清培養上清は坐骨神経結紮モデルマウスの神経障害性疼痛を改善する,
日本炎症・再生医学会, 2020年7月. 吉永薫, 塩屋園玲子, 伊藤彩実, 松木祐太, 谷本幸多朗, 渡邉佳一郎, 田中栄二 :
ソトス症候群に起因する交叉咬合を伴う骨格性下顎前突,
第63回中・四国矯正歯科学会大会, 2020年7月. 比嘉佳基, 泰江章博, 坂巻拓馬, 清水宗, 渡邊正彦, 荒井大志, 堀内信也, 田中栄二 :
Temporary Anchorage Device (TAD)を用いた非抜歯遠心移動治療の長期保定2症例．,
第63回中・四国矯正歯科学会大会, 2020年7月. 天眞寛文, 佐藤博子, 岩浅亮彦, 中上絵美子, 沢田正樹, 荒井大志, 堀内信也, 田中栄二 :
哺乳様式と不正咬合との関連性についての検討．,
第63回中・四国矯正歯科学会大会, 2020年7月. 中上絵美子, 渡邉佳一郎, 森浩喜, 天眞寛文, 堀内信也, 田中栄二 :
カモフラージュ治療が行われた片側性完全唇顎口蓋裂患者の動的治療終了時の顎顔面形態の特徴,
第30回日本顎変形症学会総会・学術大会, Vol.30, No.2, 164, 2020年6月. 片桐渉, 小林正治, 佐々木朗, 須佐美隆史, 須田直人, 田中栄二, 近津大地, 冨永和宏, 森山啓司, 山城隆, 齋藤功, 高橋哲 :
本邦における外科的矯正治療の実態調査,
第30回日本顎変形症学会総会・学術大会, 2020年6月. 中上絵美子, 渡邉佳一郎, 森浩喜, 天眞寛文, 堀内信也, 田中栄二 :
カモフラージュ治療が行われた片側性完全唇顎口蓋裂患者の動的治療終了時の顎顔面形態の特徴,
第44回日本口蓋裂学会総会・学術集会, 2020年6月. 加納史也, 小笠原直子, 橋本登, 森浩喜, 宮嵜彩, 岩本勉, 田中栄二, 山本朗仁 :
歯髄幹細胞由来無血清培養上清を用いた変形性顎関節症の治療法開発,
第19回日本再生医療学会, 20, 2020年3月. 奥住千聡, 野坂祐一, 山崎椋太郎, 天眞寛文, 佐藤博子, 岩本勉, 田中栄二 :
哺乳様式と不正咬合との関連性についての検討．,
徳島県歯科医学大会, 36, 2020年2月. 国田智成, 松木優承, 山本貴志, 武川香織, 齋藤早紀, ミツイアカギシルビアナオミ, 岩浅亮彦, 田中栄二 :
矯正歯科における歯科衛生士による口腔筋機能療法に関する臨床統計学的検討,
徳島県歯科医学大会, 34, 2020年2月. 森浩喜, 岩本勉, 齋藤早紀, 上田(山口) 公子, 高石和美, 山村佳子, 日浅雅博, 堀内信也, 田中栄二 :
本院における口唇口蓋裂児への治療の取り組み,
徳島県歯科医学大会, 28, 2020年2月. 佐藤博子, 松木佑太, 梶本昇, 武川恵美, 堀内信也, 関根一光, 田中栄二, 浜田賢一 :
通電するとグラスアイオノマーセメントの接着強度は低下する,
徳島県歯科医学大会, 28, 2020年2月. 小笠原直子, 加納史也, 橋本登, LIU YAO, 森浩喜, 寺町順平, 岩本勉, 田中栄二, 山本朗仁 :
歯髄幹細胞由来無血清培養上清を用いた変形性顎関節症の治療法開発,
徳島県歯科医学大会, 20, 2020年2月. 市原亜起, 泰江章博, ミツイアカギシルビアナオミ, 荒井大志, 沢田正樹, 親泊政一, 田中栄二 :
骨形成に関与するMsx1遺伝子C末端領域の機能解析．,
第42回日本分子生物学会年会, 2019年12月. 荒井大志, 泰江章博, ミツイアカギシルビアナオミ, 市原亜起, 沢田正樹, 親泊政一, 田中栄二 :
Functional verification of C-terminal domain of Msx1 gene in mice for craniofacial development.,
第42回日本分子生物学会年会, 2019年12月. Tsendsuren Khurel-Ochir, Takashi Izawa, Takuma Sakamaki, Hiroki Mori and Eiji Tanaka :
Immunoregulatory role of p21 on the development of osteoarthritis in the temporomandibular joint,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page288.(2019), 288, Nov. 2019. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
Rogdi plays an important role during bone and enamel development,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page283.(2019), 283, Nov. 2019. 坂巻拓馬, 七條なつ子, 高橋巧, 田中栄二 :
下顎両側第一大臼歯にヘミセクションを適用して治療した成人叢生症例の長期経過症例,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page259.(2019), 259, 2019年11月. 岩浅亮彦, 小笠原直子, 沢田正樹, ASHTAR MOHANNAD, 堀内信也, 田中栄二 :
慢性辺縁性歯周炎を伴う骨格性II級叢生に対する歯科矯正用アンカースクリューを用いた包括的治療例,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page256.(2019), 256, 2019年11月. 髙橋史子, 日浅雅博, 堀内信也, 誉田栄一, 田中栄二 :
歯科矯正学的に骨性癒着歯と診断された歯の歯科用CBCT画像を用いた鑑別診断,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page207.(2019), 207, 2019年11月. 渡邉佳一郎, 田中栄二, 出口徹 :
口腔内スキャナーおよびCBCT画像を組み合わせた3次元歯科模型の開発,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page206.(2019), 206, 2019年11月. 中野泰児, 中嶋昭, 渡辺博人, 田中栄二, 本吉満 :
材質の異なる審美ブラケットを用いた，サードオーダーベンド付与時のモーメント力の評価,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page191.(2019), 191, 2019年11月. 荒井大志, 泰江章博, ミツイアカギシルビアナオミ, 親泊政一, 田中栄二 :
歯の形態形成におけるMsx1遺伝子MH6ドメインの機能検証,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page187.(2019), 187, 2019年11月. 市原亜起, 泰江章博, 荒井大志, 沢田正樹, ミツイアカギシルビアナオミ, 親泊政一, 田中栄二 :
多数歯欠損症の原因遺伝子Msx1のC末端領域は骨形成において重要である,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page184.(2019), 184, 2019年11月. 小笠原直子, 橋本登, 山本朗仁, 田中栄二 :
変形性顎関節症に対するヒト脱落乳歯歯髄幹細胞由来無血清馴化培地の治療効果,
第78回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 78回 Page183.(2019), 183, 2019年11月. 天眞寛文, 寺町順平, 日浅雅博, 谷本幸多朗, ASHTAR MOHANNAD, Bat-Erdene Ariunzaya, 岩佐昌美, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1阻害は関節リウマチにおけるNLRP3インフラマソーム誘導性の炎症および骨破壊を抑制する,
日本骨代謝学会学術集会プログラム抄録集, 190, 2019年10月. 谷本幸多朗, 日浅雅博, 岩浅亮彦, 天眞寛文, 寺町順平, ASHTAR MOHANNAD, 岩佐昌美, 小田明日香, 曾我部公子, 大浦雅博, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
不動性骨吸収の亢進は骨髄内の骨髄腫進展を促進させる．,
日本骨代謝学会学術集会プログラム抄録集, 2019年10月. Khurel-Ochir Tsendsuren, 井澤俊, 坂巻拓馬, 森浩喜, 岩浅亮彦, 田中栄二 :
p21 deficiency is susceptible to TMJ-Osteoarthritis with mechanical stress.,
日本骨代謝学会学術集会プログラム抄録集, 2019年10月. 天眞寛文, 寺町順平, 日浅雅博, 谷本幸多朗, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐昌美, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1阻害は関節リウマチにおけるNLRP3インフラマソーム誘導性の炎症および骨破壊を抑制する．,
第37回日本骨代謝学会学術集会, 2019年10月. 谷本幸太朗, 日浅雅博, 天眞寛文, 寺町順平, ASHTAR MOHANNAD, 岩佐昌美, 小田明日香, 曽我部公子, 大浦雅博, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
不動性骨吸収の亢進は骨髄内の骨髄腫進展を促進させる,
第37回日本骨代謝学会学術集会, 2019年10月. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, 小田明日香, Kotaro Tanimoto, Soh Shimizu, Ashtar Mohannad, Takeshi Harada, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis : the therapeutic roles of TAK1 inhibition,
16th Meeting of Bone Biology Forum, Aug. 2019. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
Rogdi plays an important role during enamel mineralization.,
第59回日本先天異常学会学術集会, Jul. 2019. 田中栄二 :
矯正歯科臨床における下顎頭吸収の診断と治療方針立案, --- イブニングセミナー「矯正歯科治療における下顎頭吸収を考える」 ---,
日本顎関節学会雑誌, 2019年7月. 松本文博, 細木秀彦, 前田直樹, 安陪晋, 堀川恵理子, 松香芳三, 田中栄二 :
変形性顎関節症に関連した神経障害性疼痛の一症例,
日本顎関節学会雑誌, 2019年7月. Habuta Munenori, Akihiro Yasue, Suzuki T Ken-ichi, Fujita Hirofumi, Bando Tetsuya, Sato Keita, Seiichi Oyadomari, Eiji Tanaka and Hideyo Ohuchi :
Higher amount of the Fgf10 gene product is required for the accessory lobe formation and type 2 alveolar cell differentiation in the mouse lung as revealed by Fgf10-mosaic mutants generated by genome-editing.,
第59回日本先天異常学会学術集会, Jul. 2019. YAO RIU, 橋本登, 寺町順平, 松香芳三, 田中栄二, 山本朗仁 :
乳歯歯髄幹細胞培養上清によるマウス坐骨神経結紮モデルにおける神経障害性疼痛の改善．,
第40回日本炎症・再生医学会, 2019年7月. 坂巻拓馬, 岩浅亮彦, 森浩喜, 小笠原直子, 谷本幸多朗, ASHTAR MOHANNAD, LIU YAO, 沢田正樹, 中村竜也, 堀内信也, 田中栄二 :
矯正治療中に生じた下顎中切歯の歯肉退縮に対して結合組織移植術を行った歯性上顎前突症例―長期保定症例,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, 2019年7月. 森仁志, 森浩喜, 塩屋園玲子, 渡邉佳一郎, 堀内信也, 菅野貴浩, 田中栄二 :
閉塞性睡眠時無呼吸症候群を伴うPierre Robin Sequenceに対し下顎骨前方移動術を行った1例,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, 2019年7月. 沢田正樹, 岩浅亮彦, 吉村宗之, 市原亜起, ミツイアカギシルビアナオミ, 塩屋園玲子, 日浅雅博, 泰江章博, 田中栄二 :
シルエットを用いた側貌に対する審美的評価,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, 2019年7月. 松木佑太, 川合暢彦, 藤多睦, Khurel-Ochir Tsendsuren, 渡邊正彦, 荒井大志, 髙橋史子, 佐藤博子, 井澤俊, 田中栄二 :
巨大な上顎中切歯を抜去しマルチブラケット治療を行った一治療例,
第62回中・四国矯正歯科学会大会, Vol.31, No.1, 2019年7月. 田中栄二, 森浩喜, 岩浅亮彦, 堀内信也 :
乳児黒色性神経外胚葉性腫瘍の下顎骨亜全摘後に遊離肩甲骨移植による下顎骨再建を行った1例．,
日本顎変形症学会雑誌, 2019年6月. 泰江章博, 堀内信也, 田中栄二 :
上顎大臼歯部圧下により上下顎同時移動術を回避した下顎前突症例,
日本顎変形症学会雑誌, 2019年6月. 清水宗, 堀内信也, 天眞寛文, 岩浅亮彦, 渡邉佳一郎, 日浅雅博, 岩本勉, 田中栄二 :
徳島大学病院矯正歯科における口唇裂・口蓋裂患者の合併先天異常に関する実態調査．,
日本口蓋裂学会雑誌, 2019年5月. 渡邊正彦, 川合暢彦, 柴田愛実, 田中栄二 :
骨格性下顎前突症患者における筋機能の特徴．,
第62回日本顎口腔機能学会学術大会, 2019年4月. Islamy Rahma Hutami, Hiroki Mori, Tsendsuren Khurel-Ochir, Akiko Mino, Akihiko Iwasa, Eiji Tanaka and Takashi Izawa :
HIF1α modulates the palatal wound healing via M1/M2 marcophage reprogramming.,
第66回国際歯科研究学会日本部会総会・学術大会(JADR2018), Nov. 2018. Tsendsuren Khurel-Ochir, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Islamy Rahma Hutami and Eiji Tanaka :
The role of p21 on the development of TMJ-OA,
The 77th Annual Meeting of the Japanese Orthodontic Society, Vol.77, 79, Nov. 2018.

(キーワード): TMJ-OA / 細胞周期 (cell cycle)

田中栄二 :
歯科矯正学的な歯の移動の加速について,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集, 146, 2018年10月. 新井千博, 川合暢彦, 柘植厚志, 田中栄二, 中村芳樹 :
矯正学的歯の側方移動に対する低出力超音波パルス(LIPUS)照射の効果,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集, 229, 2018年10月. 布川隆三, 重田南, 佐川聖子, 安賀稔, Moon Won, 田中栄二 :
Maxillary Skeletal Expanderを用いた著しい上顎骨狭窄に対する戦略的アプローチ,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集, 325, 2018年10月. 金南希, 堀内信也, 市原亜起, 田中栄二 :
機能的矯正装置による下顎の誘導が功奏した，幼少期に発症した顔面非対称症症例．,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 77回 Page338(2018.10), 338, 2018年10月. 藤多睦, 重田南, 森浩喜, 岩浅亮彦, 川合暢彦, 田中栄二 :
変形性顎関節症モデルラット下顎頭及び炎症状態下軟骨細胞に対する低出力パルス超音波照射の影響,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 77回 Page320.(2018.10), 320, 2018年10月. 小笠原直子, 森浩喜, 山本朗仁, 田中栄二 :
変形性顎関節症に対するヒト脱落乳歯歯髄幹細胞由来無血清馴化培地の治療効果の検討,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 77回 Page245.(2018.10), 245, 2018年10月. 市原亜起, 泰江章博, ミツイアカギシルビアナオミ, 渡辺八十夫, 田中栄二 :
多数歯欠損症患者におけるPAX9遺伝子変異の検出,
第77回日本矯正歯科学会学術大会: 日本矯正歯科学会大会プログラム・抄録集 77回 Page244(2018.10), 244, 2018年10月. Ashtar Mohannad, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Oda Asuka, Iwasa Masami, Takeshi Harada, Ariunzaya Erdene Bat, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Shingen Nakamura, Hirokazu Miki, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Roles of ROS in induction of bone disease and cancer treatment-induced bone loss in myeloma.,
The 80th Annual Meeting of the Japanese Society of Hematology, Oct. 2018. Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Mohannad Ashtar, Ariunzaya Bat-Erdene, Iwasa Masami, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Inverse regulation of c-FLIP-mediated survival in myeloma cells and osteoclasts by TRAIL.,
The 80th Annual Meeting of the Japanese Society of Hematology, Oct. 2018. Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Oda Asuka, Mohannad Ashtar, Ariunzaya Bat-Erdene, Iwasa Masami, Kimiko Sogabe, Oura Masahiro, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Impact of denervation-induced paralysis and mechanical unloading on tumor expansion in myeloma.,
The 80th Annual Meeting of the Japanese Society of Hematology, Oct. 2018. Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Kotaro Tanimoto, Ariunzaya Bat-Erdene, Mohannad Ashtar, Masami Iwasa, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Oda Asuka, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
The effects of cathepsin K inhibition on osteocytes: its role in bone restoration in MM bone disease.,
The 80th Annual Meeting of the Japanese Society of Hematology, Oct. 2018. 安倍吉郎, 柏木圭介, 石田創士, 峯田一秀, 山下雄太郎, 吉本聖, 森浩喜, 田中栄二, 橋本一郎 :
乳児黒色性神経外胚葉性腫瘍の下顎骨亜全摘症例に対し二期的な遊離肩甲骨移植で良好な咬合を獲得した1例,
第36回日本頭蓋顎顔面外科学会学術集会, 2018年10月. 日浅雅博, 寺町順平, 天眞寛文, 谷本幸多朗, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐昌美, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
カテプシンK阻害による多発性骨髄腫骨病変部の骨量回復プロセスにおける骨細胞の役割．,
第36回日本骨代謝学会学術集会, 2018年7月. 天眞寛文, 寺町順平, 日浅雅博, 谷本幸多朗, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐昌美, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1阻害はTRAILによる破骨細胞活性化作用を遮断させると同時にTRAILの抗骨髄腫作用を増強する,
第36回日本骨代謝学会学術集会, 2018年7月. 高橋史子, 日浅雅博, 堀内信也, 誉田栄一, 田中栄二 :
パノラマX線画像による外科的亜脱臼後予後良好な骨性癒着大臼歯の鑑別診断,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 2018年7月. 森仁志, 森浩喜, 塩屋園玲子, 渡邉佳一郎, 堀内信也, 田中栄二 :
上顎中切歯の翼状捻転を伴う叢生症例,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 77-78, 2018年7月. 吉村宗之, 泰江章博, 白井愛実, 七條なつ子, 古谷昌裕, 田中栄二 :
二分割Le Fort I型骨切り術併用による上下顎移動術を行った骨格性下顎前突の2症例．,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 2018年7月. 渡邊正彦, 川合暢彦, 白井愛実, 七條なつ子, ミツイアカギシルビアナオミ, 泰江章博, 田中栄二 :
外科的矯正治療と矯正単独治療を行った骨格性下顎前突症患者の顎口腔機能評価,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 2018年7月. 武川香織, 岩浅亮彦, ミツイアカギシルビアナオミ, 国田智成, 松木優承, 山本貴志, 齋藤早紀, 川合暢彦, 田中栄二 :
歯科衛生士による歯科矯正患者に対する口腔筋機能療法に関する実態調査．,
第61回中・四国矯正歯科学会大会, Vol.30, No.1, 73-74, 2018年7月. 井澤俊, 田中栄二 :
AhRはRANK/c-Fosシグナル伝達経路を介して破骨細胞の分化を制御する,
第4回日本骨免疫学会, Vol.4, 106, 2018年6月. 天眞寛文, 寺町順平, 日浅雅博, 小田明日香, 谷本幸多朗, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐昌美, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1による破骨細胞に対するTRAILの生存・細胞死シグナル制御機構．,
第4回日本骨免疫学会, 2018年6月. 谷本幸多朗, 日浅雅博, 天眞寛文, 寺町順平, 小田明日香, ASHTAR MOHANNAD, Ariunzaya Bat-Erdene, 岩佐昌美, 曽我部公子, 大浦雅弘, 原田武志, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
神経切断による麻痺と免荷の骨髄腫の進展への影響．,
第4回日本骨免疫学会, 2018年6月. Hutami Islamy Rahma, 井澤俊, 森浩喜, 岡彰子, Khurel-Ochir Tsendsuren, 岩浅亮彦, 田中栄二 :
低酸素応答遺伝子 HIF-1alpha は M1/M2 マクロファージのリプログラミングを介して口蓋創傷治癒を制御する．,
第42回日本口蓋裂学会総会・学術集会抄録号, Vol.43, No.2, 182, 2018年5月. 谷本幸多朗, 森浩喜, 井澤俊, 川合暢彦, 泰江章博, 田中栄二 :
徳島大学病院における過去 10 年間の口唇裂・口蓋裂患者に関する実態調査,
第42回日本口蓋裂学会総会・学術集会抄録号, Vol.43, No.2, 178, 2018年5月. 泰江章博, 白井愛実, 七條なつ子, 田中栄二 :
二分割Le Fort I型骨切り術併用による上下顎移動術を行った下顎側方偏位例,
日本顎変形症学会雑誌, Vol.28, No.2, 210, 2018年5月. 土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代 :
ゲノム編集Fgf10モザイク変異体の組織学的解析,
第123回日本解剖学会総会・全国集会, 2018年3月. 吉原靖智, 鈴木善貴, 中川聖子, 岩浅亮彦, 鴨居浩平, 大倉一夫, 細木眞紀, 田中栄二, 松香芳三 :
睡眠衛生指導とパラタルスプリントにより睡眠時ブラキシズムをコントロールした症例,
四国歯学会雑誌, 2018年3月. 田中栄二 :
下顎頭吸収への矯正歯科的対応,
第3回冬期口腔外科臨床研究会(東北), 2018年2月. Takashi Izawa, Rieko Arakaki, Eiji Tanaka and Naozumi Ishimaru :
Crosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone homeostasis (selected for oral presentation by English at Workshop "Cytokines and chemokines-2" and poster session),
Proceedings of the Japanese Society for Immunology, Vol.46, 36, Dec. 2017.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL) / AhR

井澤俊, 新垣理恵子, 田中栄二, 石丸直澄 :
The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis,
2017年度生命科学系学会合同年次大会第90回日本生化学大会第40回日本分子生物学会年会, 402, 2017年12月.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL) / aryl hydrocarbon receptor / c-Fos

土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代 :
CRISPR/Cas9システムにより作製したモザイク変異マウスの組織学的解析．,
第40回日本分子生物学会, 2017年12月. 田中栄二 :
安全・安心で効率的な歯の移動をめざして,
第29回日本舌側矯正歯科学会学術大会・総会特別講演, 2017年11月. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
CRISPR/Cas9-mediated targeting for the analysis of ROGDI in enamel mineralization.,
第65回国際歯科研究学会日本部会総会・学術大会 JADR, Nov. 2017. Akihiro Yasue, Daishi Arai, Silvia Naomi Mitsui Akagi, Seiichi Oyadomari and Eiji Tanaka :
In vivo deletion assay of mouse MSX1 gene using CRISPR/Cas system.,
第65回国際歯科研究学会日本部会総会・学術大会 JADR, Nov. 2017. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
CRISPR/Cas9-mediaated targeting for the analysis of ROGDI in enamel mineralization,
The 65th Annual Meeting of Japanese Association for Dental Research, Nov. 2017. Akihiro Yasue, Daishi Arai, Silvia Naomi Mitsui Akagi, Seiichi Oyadomari and Eiji Tanaka :
In vivo deletion assay of mouse MSX1 gene using CRISPR/Cas system,
The 65th Annual Meeting of Japanese Association for Dental Research, Nov. 2017. 土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代 :
CRISPR-Cas9システムにより作製した形態形成遺伝子(Pax6およびFgf10)のモザイク変異マウスの解析,
第72回中国・四国支部学術集会, 2017年10月. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
The role of Rogdi in enamel biomineralization.,
第76回日本矯正歯科学会学術大会, Oct. 2017. 七條なつ子, ミツイアカギシルビアナオミ, 荒井大志, 川合暢彦, 田中栄二 :
片側性の多数歯根肥大歯により開咬を呈した症例,
第76回日本矯正歯科学会学術大会, 2017年10月. 岡彰子, 堀内信也, 松田りえ, 塩屋園玲子, 森山啓司, 田中栄二 :
先天性頚部リンパ管腫を伴う顎偏位症例に対する矯正治療後の長期経過報告,
第76回日本矯正歯科学会学術大会, 2017年10月. 岩浅亮彦, 小西晴奈, 藤本果南, 小笠原直子, 渡邉佳一郎, 日浅雅博, 堀内信也, 田中栄二 :
徳島大学病院矯正歯科患者における永久歯埋伏に関する臨床統計学的調査,
第76回日本矯正歯科学会学術大会, 2017年10月. 白井愛実, 川合暢彦, ミツイアカギシルビアナオミ, 七條なつ子, 泰江章博, 田中栄二 :
骨格性下顎前突症患者の顎口腔機能に対する術後ガム咀嚼訓練の効果,
第76回日本矯正歯科学会学術大会, 2017年10月. 荒井大志, 泰江章博, ミツイアカギシルビアナオミ, 親泊政一, 田中栄二 :
CRISPR/Casシステムを用いたMsx1遺伝子各ドメインの形態形成における機能検証．,
第76回日本矯正歯科学会学術大会, 2017年10月. Islamy Rahma Hutami, Takashi Izawa, Akihiko Iwasa, Akiko Mino, Tsendsuren Khurelochir, Hiroki Mori and Eiji Tanaka :
Role of hypoxia inducible factor-1 alpha in the palatal wound healing,
The 76th Annual Meeting of the Japanese Orthodontic Society Academic Exhibits (AE-012), 309, Oct. 2017. 田中栄二 :
下顎頭吸収への矯正歯科的対応,
第42回日本顎関節学会学術講演会, 2017年10月. ミツイアカギシルビアナオミ, 泰江章博, 田中栄二 :
Rogdi 遺伝子はマウスエナメル質石灰化において重要である,
第59回歯科基礎医学会学術大会, 2017年9月. 泰江章博, ミツイアカギシルビアナオミ, 荒井大志, 田中栄二 :
CRISPR/Cas システムを用いた in vivo におけるマウス Msx1 機能ドメインの解析,
第59回歯科基礎医学会学術大会, 2017年9月. 田中栄二 :
特発性下顎頭吸収の診断,
第30回日本顎関節学会総会・学術大会メインシンポジウム(特発性下顎頭吸収を含む開咬の診断と治療)，, 2017年7月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, Ariunzaya Baterdene, 岩佐昌美, 藤井志朗, 賀川久美子, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TRAILは破骨細胞を活性化させるが，TAK1阻害により骨髄腫細胞とともに破骨細胞にもTRAILのアポトーシス誘導活性が惹起できる,
第35回日本骨代謝学会学術集会, 2017年7月. 岩浅亮彦, 井澤俊, 森浩喜, 岡彰子, 藤多睦, 川合暢彦, 堀内信也, 田中栄二 :
歯科矯正患者における進行性下顎頭吸収の発現頻度とその危険因子の検索,
第30回日本顎関節学会総会・学術大会, 2017年7月. 藤多睦, 重田南, 岩浅亮彦, 森浩喜, 川合暢彦, 井澤俊, 堀内信也, 田中栄二 :
変形性顎関節症モデルラット下顎頭及び炎症状態下軟骨細胞に対する低出力パルス超音波による影響．,
日本顎関節学会雑誌, 2017年7月. 井澤俊, 田中栄二, 石丸直澄 :
核内受容体AhRはRANK/c-Fosシグナル伝達経路を介して破骨細胞の分化を制御する,
第35回日本骨代謝学会学術集会 (口演発表), 2017年7月. 松本文博, 細木秀彦, 前田直樹, 安陪晋, 堀川恵理子, 葉山莉香, 松香芳三, 田中栄二 :
顎関節注射後に咬合不全および著明な開口障害を呈した一症例,
日本顎関節学会雑誌, 2017年7月. 森仁志, 森浩喜, 塩屋園玲子, 渡邉佳一郎, 堀内信也, 田中栄二 :
ペンデュラムアプライアンスを使用して上顎第一大臼歯を遠心移動した3症例,
第60回中・四国矯正歯科学会大会, 2017年7月. 藤本果南, 小西晴奈, 岩浅亮彦, 市原亜起, 白井愛実, 渡邉佳一郎, 日浅雅博, 森博世, 堀内信也, 田中栄二 :
歯科矯正患者における埋伏永久歯に関する実態調査,
第60回中・四国矯正歯科学会大会, 2017年7月. 小笠原直子, 岩浅亮彦, 佐藤博子, 藤多睦, 岡彰子, 伊藤彩実, 七條なつ子, 川合暢彦, 井澤俊, 田中栄二 :
矯正患者における永久歯の先天的欠如に関する臨床統計調査,
第60回中・四国矯正歯科学会大会, 2017年7月. 荒井大志, 渡邉佳一郎, Hutami Islamy Rahma, 天眞寛文, 篠原丈裕, 木内奈央, 田中栄二 :
矯正歯科患者における近年の永久前歯歯冠幅径の変化,
第60回中・四国矯正歯科学会大会学術口演, 2017年7月. 白井愛実, 川合暢彦, 七條なつ子, 森博世, 泰江章博, 田中栄二 :
骨格性下顎前突症患者における外科的矯正治療前後の顎口腔機能評価,
第27回日本顎変形症学会大会, 2017年6月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, Baterdene Ariunzaya, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1阻害はTRAILの抗骨髄腫作用を増強するともに骨吸収促進活性を抑制活性に変換する．,
第42回日本骨髄腫学会, 2017年5月. 天知良太, 中村信元, 日浅雅博, 小田明日香, バットエルデネアリウンザヤ, 寺町順平, 天眞寛文, 渡邉佳一郎, 三木浩和, 賀川久美子, 藤井志朗, 田中栄二, 松本俊夫, 安倍正博 :
骨形成誘導による骨髄腫細胞のエネルギー代謝の抑制,
第42回日本骨髄腫学会学術集会, 2017年5月. Akihiro Yasue, Daishi Arai, Silvia Naomi Mitsui Akagi, Seiichi Oyadomari and Eiji Tanaka :
Functional verification of each Msx homology domain of Msx1 gene for tooth morphogenesis using CRISPR/Cas system.,
第50回日本発生生物学会, May 2017. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Seiichi Oyadomari and Eiji Tanaka :
Rogdi is required for enamel biomineralization,
第50回日本発生生物学会, May 2017. 土生田宗憲, 泰江章博, 板東哲哉, 佐藤恵太, 井上順治, 親泊政一, 大内淑代, 田中栄二 :
CRISPR/Cas9システムにより作製したPax6モザイク変異体の組織学的解析,
第122回日本解剖学会総会・全国集会, 2017年3月. 小西晴奈, 藤本果南, 岩浅亮彦, 渡邉佳一郎, 堀内信也, 田中栄二 :
不正咬合患者における埋伏歯についての臨床統計学的調査,
四国歯学会第50回例会, 2017年3月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
30. 天真寛文, 寺町順平, 小田明日香, 天知良太, , ,破骨細胞系細胞はアポトーシス誘引因子TRAILを生存促進・破骨細胞形成誘導因子として利用する:TAK1-Pim-2経路の役割,
第19回日本癌と骨病変研究会, 2016年11月. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Issei Imoto, Seiichi Oyadomari and Eiji Tanaka :
Biological validation of tooth agenesis causing mutation using CRISPR/Cas system in mice.,
The 75th Annual Meeting of the Japanese Orthodontic Society, Nov. 2016. ODO BAYARSAIKHAN, Nobuhiko Kawai, Hiroyo Mori, Nao Kinouchi and Eiji Tanaka :
Effectiveness of myostatin targeting siRNA and ActRIIB-Fc fusion protein in skeletal muscle mass,
The 75th Annual Meeting of the Japanese Orthodontic Society, Nov. 2016. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Takehiro Shinohara, Akiko Mino and Eiji Tanaka :
The role of osteoclast in the spontaneously developed temporomandibular joint arthritis of the MRL/lpr mice,
The 75th Annual Meeting of the Japanese Orthodontic Society, 321, Nov. 2016. 田中栄二 :
よく噛むことは楽しく生きること,
第75回日本矯正歯科学会市民公開講座, 2016年11月. 黒田優子, 岩田光弘, 松本一真, 篠原丈裕, 玉村長都, 田中栄二 :
中等度歯周炎および咬合平面の傾斜を伴う成人上顎前突患者に対して包括的歯科治療を行った1症例．,
日本矯正歯科学会大会プログラム・抄録集. 第75回大会, 2016年11月. 天眞寛文, 渡邉佳一郎, 白井愛実, 七條なつ子, 田中栄二 :
新たな下顎臼歯の遠心移動量および移動様式の予測指標の開発-第2報-,
日本矯正歯科学会大会プログラム・抄録集. 第75回大会, 2016年11月. 渡邉佳一郎, 天眞寛文, 白井愛実, 七條なつ子, 田中栄二 :
新たな下顎臼歯の遠心移動量および移動様式の予測指標の開発-第1報-,
日本矯正歯科学会大会プログラム・抄録集. 第75回大会, 2016年11月. 三野彰子, 井澤俊, Hutami Islamy Rahma, 篠原丈裕, 森浩喜, 田中栄二 :
変形性顎関節症における低酸素誘導因子HIF-1αの機能解析,
日本矯正歯科学会大会プログラム・抄録集. 第75回大会, 2016年11月. 新井千博, 川合暢彦, 下田信治, 田中栄二, 中村芳樹 :
矯正学的歯の側方移動に対する低出力超音波パルス(LIPUS)照射の効果,
日本矯正歯科学会大会プログラム・抄録集. 第75回大会, 2016年11月. 日浅雅博, 天知良太, 天眞寛文, 堀内信也, 安倍正博, 石丸直澄, 田中栄二 :
RelBは古典的NF-κB経路の活性化を阻害し骨癒合不全と偽関節形成を予防する,
日本矯正歯科学会大会プログラム・抄録集., 192., 2016年11月. 白井愛実, 川合暢彦, BAYARSAIKHAN ODO, 七條なつ子, 森博世, 泰江章博, 堀内信也, 田中栄二 :
下顎骨単独骨切り術と上下顎同時移動術を行った骨格性下顎前突症例の顎顔面形態の比較,
日本矯正歯科学会大会プログラム・抄録集., 218, 2016年11月. 森仁志, 森浩喜, 篠原丈裕, 天知良太, 塩屋園玲子, 渡邉佳一郎, 堀内信也, 菅野貴浩, 田中栄二 :
比較的大きな顎裂を有する口唇口蓋裂患者に対する骨トランスポート骨延長法の応用,
日本矯正歯科学会大会プログラム・抄録集., 263., 2016年11月. 寺町順平, 森裕史, 越智保夫, 天知良太, 小田明日香, 日浅雅博, 原田武志, 藤井志朗, 中村信元, 三木浩和, 賀川久美子, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
Potent induction of bone formation by anti-resorptive cathepsin K inhibitor in myeloma.,
第77回日本血液学会学術集会,, 2016年10月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TAK1 inhibition subverts TRAIL-mediated osteoclastogenesis.,
第77回日本血液学会学術集会,, 2016年10月. 天知良太, 日浅雅博, 寺町順平, 小田明日香, 天眞寛文, 渡邉佳一郎, 中村信元, 三木浩和, 賀川久美子, 藤井志朗, 遠藤逸郎, 田中栄二, 松本俊夫, 安倍正博 :
Mechanism of the TRPV1 up-regulatation in myeloma cells and adaptation to an acidic microenvironment.,
第77回日本血液学会学術集会,, 2016年10月. 渡邉佳一郎, 寺町順平, 天知良太, 小田明日香, 天眞寛文, 岩浅正美, 日浅雅博, 中村信元, 遠藤逸郎, 川谷誠, 長田裕之, 田中栄二, 松本俊夫, 安倍正博 :
Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFb1 in mouse gingival epithelial cells,
第77回日本血液学会学術集会,, 2016年10月. 佐藤博子, 梶本昇, 日浅雅博, 堀内信也, 浜田賢一, 田中栄二 :
イオン液体を混和したレジンセメントの特性-矯正用レジンセメントにおける検討-,
日本歯科理工学会近畿中四国地方会夏期セミナー, 2016年8月. 山野栄三, 山野玲子, 谷本幸太郎, 田中栄二 :
下顎骨の過小を主徴候としたPierre-Robin症候群患児の矯正歯科治療例,
中·四国矯正歯科学会雑誌, Vol.28, No.(1), 65-74, 2016年8月. 黒田優子, 堀内信也, 渡邉佳一郎, 泰江章博, 田中栄二 :
口唇裂口蓋裂児の裂型は幼児期における上顎歯槽部の垂直的な成長に影響を及ぼす,
中·四国矯正歯科学会雑誌, Vol.28, No.(1), 127, 2016年8月. 渡邉佳一郎, 寺町順平, 天知良太, 小田明日香, 天眞寛文, 日浅雅博, 中村信元, 三木浩和, 遠藤逸朗, 川谷誠, 長田裕之, 田中栄二, 松本俊夫, 安倍正博 :
リベロマイシンAによる酸性環境での骨髄腫細胞の治療抵抗性の克服,
日本骨代謝学会学術集会プログラム抄録集 (1349-0761)34回 Page183(2016.07), 183, 2016年7月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
破骨細胞はTAK1の発現誘導を介しアポトーシスを抑制しTRAILにより成熟活性化される,
日本骨代謝学会学術集会プログラム抄録集 (1349-0761)34回 Page183(2016.07), 183, 2016年7月. 田中栄二 :
成長期児童における変形性顎関節症の発症率とそのリスク因子, --- シンポジウム2(変形性顎関節症への取り組みー小児から高齢者までー) ---,
第29回日本顎関節学会総会・学術大会シンポジウム2, 2016年7月. 安陪晋, 堀川恵理子, 田中栄二, 松本文博, 大本勝弘, 葉山莉香, 宮城麻友, 大倉一夫, 松香芳三 :
徳島大学病院顎関節症外来に来院した顎関節症患者の臨床統計学的調査,
日本顎関節学会雑誌, 2016年7月. 岩浅亮彦, 森浩喜, 井澤俊, 篠原丈裕, 三野彰子, 佐藤南, 堀内信也, 田中栄二 :
不正咬合患者における顎関節症の臨床統計学的調査,
第29回日本顎関節学会総会・学術大会ポスター発表, Vol.28, No.Supplement, 145, 2016年7月. 篠原丈裕, 井澤俊, 岩浅亮彦, 森浩喜, 三野彰子, 犬伏俊博, 田中栄二 :
変形性顎関節症モデルマウス下顎頭におけるヒアルロン酸代謝機構の役割,
第29回日本顎関節学会総会・学術大会ポスター発表, Vol.28, No.Supplement, 123, 2016年7月. 三野彰子, 井澤俊, 篠原丈裕, 森浩喜, 田中栄二 :
HIF-1alpha+/-マウスを用いた変形性顎関節症におけるHIF-1alphaの機能解析,
第29回日本顎関節学会総会・学術大会一般口演, Vol.28, No.Supplement, 115, 2016年7月. 藤多睦, 川合暢彦, 塩田智子, BAYARSAIKHAN ODO, 森博世, 井澤俊, 大谷淳二, 廣瀬尚人, 谷本幸太郎, 田中栄二 :
上顎骨延長術と下顎枝垂直骨切り術を行った左側唇顎口蓋裂症例,
第59回中・四国矯正歯科学会大会学術口演, 2016年7月. 佐藤博子, 井澤俊, 森浩喜, 岩浅亮彦, 木内奈央, 堀内信也, 田中栄二 :
Le Fort III型骨延長術後に上下顎骨移動術を施行したApert症候群の1例,
第59回中・四国矯正歯科学会大会学術口演, 2016年7月. 七條なつ子, 黒田晋吾, 古谷昌裕, 田中栄二 :
ガミースマイルを伴う過蓋咬合症例に対する上顎前歯圧下の有用性,
第26回日本顎変形症学会大会, 2016年6月. 佐藤南, 岩浅亮彦, 森浩喜, 堀内信也, 田中栄二 :
関節滑膜細胞に対する低出力超音波照射によって生じる抗炎症シグナル伝達経路の解明,
日本顎関節学会雑誌., 124., 2016年6月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TRAILは破骨細胞に細胞死を誘導せず，破骨細胞分化・生存を促進する.,
第41回日本骨髄腫学会, 2016年5月. 泰江章博, 前田有一, ミツイアカギシルビアナオミ, 白井愛実, 堀内信也, 橋本一郎, 田中栄二 :
過大な顎裂を有する片側性唇顎蓋裂に対し集学的治療を行った1例,
第40回日本口蓋裂学会総会・学術集会抄録号, Vol.41, No.2, 137, 2016年5月. 前田有一, 黒田晋吾, KARIMA QURNIA MANSJUR, 木内奈央, 天知良太, Wazen Riza, Antonio Nanci, 田中栄二 :
Dermatopontinおよびvascular adhesion protein 1の発現亢進が骨芽細胞のナノ処理チタンへの接着を促進する,
第74回日本矯正歯科学会大会プログラム・抄録集, 198, 2015年11月. MANSJUR KARIMA QURNIA, Shingo Kuroda, Yuichi Maeda, Minami Sato, Silvia Naomi Mitsui Akagi, ODO BAYARSAIKHAN, Keiichiro Watanabe and Eiji Tanaka :
Applications of parathyroid hormone and low intensity pulsed ultrasound enhance fracture healing in osteoporotic rats,
第74回日本矯正歯科学会大会プログラム・抄録集, 142, Nov. 2015. 堀内信也, 泰江章博, 川合暢彦, 白井愛実, 天眞寛文, 佐藤南, 阪間稔, 田中栄二 :
矯正歯科用接着剤のフッ素徐放機能に関する検討,
第74回日本矯正歯科学会大会プログラム・抄録集, 212, 2015年11月. 三野彰子, 井澤俊, 篠原丈裕, 森浩喜, 森博世, 岩浅亮彦, 田中栄二 :
マウス下顎頭軟骨の形成，維持におけるHIF-1αの機能解析,
第74回日本矯正歯科学会大会プログラム・抄録集, 204, 2015年11月. 金南希, 吉丸哲郎, 片桐豊雅, 田中栄二 :
乳がん細胞におけるがん抑制分子PHB2のエストロゲン依存性核内移行機序の解明,
第74回日本矯正歯科学会大会プログラム・抄録集, 194, 2015年11月. 森浩喜, 井澤俊, 三野彰子, 岩浅亮彦, 内田玲子, 田中栄二 :
S1P/Smad3シグナルクロストークを介した変形性顎関節症の病態メカニズムの解明,
第74回日本矯正歯科学会大会プログラム・抄録集, 194, 2015年11月. 井澤俊, 森浩喜, 篠原丈裕, 三野彰子, 塩田智子, 犬伏俊博, 岩浅亮彦, 田中栄二 :
変形性顎関節症モデルマウスにおけるレパミピドの治療効果の検討,
第74回日本矯正歯科学会大会プログラム・抄録集, 193, 2015年11月. 篠原丈裕, 井澤俊, 三野彰子, 森浩喜, 七條なつ子, 犬伏俊博, 田中栄二 :
実験的な変形性顎関節症モデルマウス下顎頭におけるヒアルロン酸の役割,
第74回日本矯正歯科学会大会プログラム・抄録集, 190, 2015年11月. 佐藤南, 永田久美子, 堀内信也, 黒田晋吾, 山村佳子, 東雅之, 田中栄二 :
低出力パルス超音波は唾液腺炎に対して抗炎症作用を有し唾液分泌を促進させる,
第74回日本矯正歯科学会大会プログラム・抄録集, 164, 2015年11月. 田中栄二, 井澤俊, 森浩喜, 川合暢彦, 泰江章博, 堀内信也 :
片側性顎関節円板前方転位が健側顎関節に及ぼす影響に関する生体力学的解析,
第23回顎顔面バイオメカニクス学会プログラム, 193, 2015年11月. Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, A Oda, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, H Miki, Kumiko Kagawa, Shiroh Fujii, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Mechanism of the TRPV1 up-regulatation in myeloma cells and adaptation to an acidic microenvironment,
第77回日本血液学会学術集会, Oct. 2015. Keiichiro Watanabe, Jumpei Teramachi, H Mori, Y Ochi, Ryota Amachi, A Oda, Masahiro Hiasa, T Harada, Shiroh Fujii, Shingen Nakamura, H Miki, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
Potent induction of bone formation by anti-resorptive cathepsin K inhibitor in myeloma,
第77回日本血液学会学術集会, Oct. 2015. 田中栄二 :
歯科矯正用アンカースクリューを用いたインプラント矯正治療,
日本口腔インプラント学会誌, Vol.28, No.3, 352, 2015年9月. 高原一菜, 黒田晋吾, 堀内信也, 川合暢彦, 森博世, 塩田智子, 七條なつ子, BAYARSAIKHAN ODO, 田中栄二 :
徳島大学病院矯正歯科における初診患者に対するアンケート調査,
第58回中·四国矯正歯科学会大会, 19, 2015年7月. 吉永薫, 渡邉佳一郎, 中村瑠里, 佐藤南, ミツイアカギシルビアナオミ, 天知良太, 岩浅亮彦, 堀内信也, 黒田晋吾, 田中栄二 :
歯科矯正用アンカースクリューの導入による診断内容の変化∼抜歯・非抜歯および抜歯部位の判定に関する検討∼,
第58回中·四国矯正歯科学会大会, 18, 2015年7月. 天眞寛文, 渡邉佳一郎, 七條なつ子, 三野彰子, 森浩喜, KARIMA QURNIA MANSJUR, 泰江章博, 黒田晋吾, 田中栄二 :
歯科矯正用アンカースクリューを用いた下顎臼歯遠心移動量および移動様式の治療前予測に関する検討,
第58回中·四国矯正歯科学会大会, 14, 2015年7月. 白井愛実, 川合暢彦, 森博世, 七條なつ子, BAYARSAIKHAN ODO, 篠原丈裕, 井澤俊, 木内奈央, 田中栄二 :
徳島大学病院矯正歯科における顎変形症患者の臨床統計学的検討(第2 報),
第58回中·四国矯正歯科学会大会, 13, 2015年7月. 森浩喜, 井澤俊, 田中栄二 :
変形性顎関節症の病態形成におけるS1P/Smad3シグナルの役割,
日本顎関節学会雑誌, Vol.27, No.Supplement, 149, 2015年7月. 井澤俊, 森浩喜, 篠原丈裕, 岩浅亮彦, 田中栄二 :
変形性顎関節症モデルマウスにおけるレパミピドの治療効果の検討,
日本顎関節学会雑誌, Vol.27, No.Supplement, 148, 2015年7月. 安陪晋, 松本文博, 田中栄二, 大本勝弘, 葉山莉香, 宮城麻友, 大倉一夫, 松香芳三 :
顎関節症外来患者におけるアンケートを用いた睡眠の質の実態調査,
日本顎関節学会・日本口腔顔面痛学会, 2015年7月. 細木秀彦, 前田直樹, 松本文博, 松香芳三, 田中栄二 :
MRI検査による顎関節症患者の経時的観察,
日本顎関節学会雑誌, Vol.27, No.Suppl., 111, 2015年7月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
TRAILは破骨細胞分化・生存を促進する:TAK-1による生と死の運命制御,
第1回日本骨免疫学会, 137, 2015年7月. 天知良太, 日浅雅博, 寺町順平, 小田明日香, 天眞寛文, 渡邉佳一郎, 中村信元, 賀川久美子, 三木浩和, 藤井志朗, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
酸環境での骨髄腫細胞のDR4発現抑制:酸によるエピジェネティックな遺伝子発現制御,
第1回日本骨免疫学会, 108, 2015年7月. 天知良太, 日浅雅博, 寺町順平, 小田明日香, 渡邉佳一郎, 天眞寛文, 中村信元, 三木浩和, 遠藤逸朗, 近藤剛史, 田中栄二, 松本俊夫, 安倍正博 :
酸性環境での骨髄腫細胞のTRPV1の発現亢進と酸環境への適応,
日本骨代謝学会学術集会プログラム抄録集, 165, 2015年7月. 天眞寛文, 寺町順平, 小田明日香, 天知良太, 日浅雅博, 渡邉佳一郎, 中村信元, 三木浩和, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
アポトーシス誘導因子TRAILによる破骨細胞分化・生存の促進,
日本骨代謝学会学術集会プログラム抄録集, 164, 2015年7月. Akihiro Yasue, Hitomi Kono, Tetsuya Bando, Yoshiyasu Ishimaru, Junji Inoue, Takahiro Watanabe, Seiichi Oyadomari, Sumihare Noji, Taro Mito, Hideyo Ohuchi and Eiji Tanaka :
Study of Pax6-deficient mosaic mice generated by the CRISPR/Cas system,
第48回日本発生生物学会, Jun. 2015. 高原一菜, 堀内信也, 渡邉佳一郎, 黒田晋吾, 橋本一郎, 田中栄二 :
顎裂部唇側に腸骨海綿骨移植術を施行した両側性唇顎口蓋裂症例,
日本口蓋裂学会雑誌抄録号(39回総会・学術集会), Vol.40, No.2, 161, 2015年5月. 阿部直樹, 黒田晋吾, 古谷昌裕, 田中栄二 :
外科的矯正治療後の顔貌予測システムの臨床的評価,
日本顎変形症学会雑誌第25回総会・学術大会プログラム・抄録号, Vol.25, No.2, 125, 2015年5月. 七條なつ子, 黒田晋吾, 佐藤南, 阿部直樹, 古谷昌裕, 田中栄二 :
二分割Le Fort Ⅰ型骨切り術を施行した重篤な前歯部開咬を伴う骨格性下顎前突症例,
日本顎変形症学会雑誌第25回総会・学術大会プログラム・抄録号, Vol.25, No.2, 181, 2015年5月. 田中栄二 :
歯科矯正用アンカースクリューを用いたインプラント矯正治療,
第35回日本口腔インプラント学会中部支部総会・学術大会, 2014年12月. 河野仁美, 泰江章博, 石丸善康, 井上順治, 渡辺崇仁, 板東哲哉, 親泊政一, 野地澄晴, 三戸太郎, 山本卓, 田中栄二, 大内淑代 :
CRISPR/CasシステムによるPax6 遺伝子破壊マウスの解析,
第37回日本分子生物学会, 2014年11月. MANSJUR KARIMA QURNIA, Shingo Kuroda, Minami Sato, KHALIUNAA GANZORIG, Yuichi Maeda, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka :
Effectiveness of low-intensity pulsed ultrasound for the treatment of tibial fractures in osteoporotic rats,
第73回日本矯正歯科学会大会・第5回日韓ジョイントミーティングプログラム・抄録集, 350, Oct. 2014. KHALIUNAA GANZORIG, Shingo Kuroda, Yuichi Maeda, MANSJUR KARIMA QURNIA, Kumiko Nagata and Eiji Tanaka :
Low-intensity pulsed ultrasound enhances bone formation around titanium and stainless steel mini-screw implants,
第73回日本矯正歯科学会大会・第5回日韓ジョイントミーティングプログラム・抄録集, 344, Oct. 2014. 黒田晋吾, 七條なつ子, 三野彰子, KARIMA QURNIA MANSJUR, GANZORIG KHALIUNAA, 玉村長都, 岩田光弘, 田中栄二 :
部分無歯症患者の包括的歯科治療における歯科矯正用アンカースクリューの有用性,
第73回日本矯正歯科学会大会プログラム・抄録集, 314, 2014年10月. 中嶋昭, 佐野麗美, 田中栄二, 前野正夫, シューラーチャールズ, 清水典佳 :
二次口蓋癒合時における3種の異なるTGF-β受容体の下流シグナルへの影響,
第73回日本矯正歯科学会大会プログラム・抄録集, 276, 2014年10月. 森浩喜, 井澤俊, 田中栄二 :
変形性顎関節症の病態形成におけるS1P/Smad3シグナルの役割,
第73回日本矯正歯科学会大会プログラム・抄録集, 217, 2014年10月. 塩田智子, 安倍知紀, 川合暢彦, 塩田智子, 二川健, 田中栄二 :
LPS誘導性筋萎縮関連遺伝子発現を抑制しうるフラボノイドの探索とその抑制機構の解明,
第73回日本矯正歯科学会大会プログラム・抄録集, 212, 2014年10月. 川合暢彦, 平坂勝也, 七條なつ子, 塩田智子, 森博世, 木内奈央, 二川健, 田中栄二 :
アテロコラーゲンを担体とした抗ユビキチン化ペプチドによる骨格筋萎縮抑制法の開発,
第73回日本矯正歯科学会大会プログラム・抄録集, 209, 2014年10月. 佐藤南, 永田久美子, 堀内信也, 黒田晋吾, 山村佳子, 東雅之, 田中栄二 :
唾液腺に対する低出力パルス超音波照射の影響の検討,
第73回日本矯正歯科学会大会プログラム・抄録集, 176, 2014年10月. 七條なつ子, 川合暢彦, 森博世, BAYARSAIKHAN ODO, 田中栄二 :
軟食飼育による咀嚼性刺激の低下は下顎骨の恒常性を負に調節する,
第73回日本矯正歯科学会大会プログラム・抄録集, 170, 2014年10月. 田中栄二 :
マウスピース矯正治療とその問題点,
第2回全国大会・国際マウスピース矯正学会準備会, 2014年9月. 天知良太, 日浅雅博, 渡邉佳一郎, 寺町順平, 小田明日香, 渡邉佳一郎, 中村信元, 遠藤逸朗, 田中栄二, 松本俊夫, 安倍正博 :
酸が惹起する骨髄腫細胞の酸感受と生存シグナルの悪循環,
日本骨代謝学会学術集会プログラム抄録集, 225, 2014年7月. 森浩喜, 井澤俊, 田中栄二 :
変形性顎関節症の病態形成におけるSmad3の役割,
日本顎関節学会雑誌, Vol.26, No.Supplement, 107, 2014年7月. 松本文博, 藤澤健司, 細木秀彦, 安陪晋, 松香芳三, 田中栄二 :
顎関節症と鑑別を要する疾患あるいは障害に関する調査-紹介により顎関節症外来を受診した患者における検討-,
日本顎関節学会雑誌, Vol.26, No.Supplement, 2014年7月. 三野彰子, 黒田晋吾, 七條なつ子, KARIMA QURNIA MANSJUR, GANZORIG KHALIUNAA, 田中栄二 :
緩みにくい新型歯科矯正用アンカースクリューの開発 -第一報埋入・緩みトルクの評価-,
第57回中·四国矯正歯科学会大会, 23, 2014年7月. 篠原丈裕, 渡邉佳一郎, 森浩喜, 井澤俊, 堀内信也, 黒田晋吾, 田中栄二 :
顎関節内障を有する骨格性下顎前突症に対する矯正歯科治療の一治験例,
第57回中·四国矯正歯科学会大会, 21, 2014年7月. 佐藤南, 藤原慎視, 川合暢彦, 堀内信也, 黒田晋吾, 近藤壽郎, 田中栄二 :
下顎頭骨軟骨腫による顔面非対称症例に対し下顎骨切除および対側下顎枝矢状分割術を同時施行した1例,
第24回日本顎変形症学会大会, 2014年6月. 川合暢彦, 高原一菜, 森博世, 堀内信也, 黒田晋吾, 田中栄二 :
外科的急速口蓋骨拡大術を用いた上顎歯列弓狭窄症例,
第24回日本顎変形症学会大会, 2014年6月. 篠原丈裕, 渡邉佳一郎, 三野彰子, 米田尚子, 高原一菜, 泰江章博, 堀内信也, 黒田晋吾, 田中栄二 :
口唇裂・口蓋裂患者における歯科矯正治療の実態調査,
第38回日本口蓋裂学会総会・学術集会, 2014年5月. 岩浅亮彦, 黒澤実愛, 新垣理恵子, 山田安希子, 田中栄二, 工藤保誠, 石丸直澄 :
Relationship between aromatase-related obesity and autoimmunity in Sjogren's syndorome.,
日本免疫学会総会·学術集会記録, 2013年12月. Akihiro Yasue, Silvia Naomi Mitsui Akagi, Teppei Watanabe, T Sakuma, Seiichi Oyadomari, T Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka :
A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system,
第36回日本分子生物学会, Dec. 2013. Keiichiro Watanabe, Masahiro Abe, H Mori, K Udaka, M Iwasa, D Hanson, Ryota Amachi, Masahiro Hiasa, T Harada, Shiroh Fujii, Shingen Nakamura, H Miki, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka and Toshio Matsumoto :
Bone restoration and tumor suppression in myeloma by cathepsin K inhibition with Bortezomib,
第75回日本血液学会学術集会, Oct. 2013. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Shinya Horiuchi, Shingo Kuroda and Eiji Tanaka :
Long-term stability of conservative orthodontic treatment in a patient with temporomandibular joint disorder,
第72回日本矯正歯科学会大会プログラム・抄録集, Oct. 2013. 荒井大志, 泰江章博, ミツイアカギシルビアナオミ, 米田尚子, 渡邉哲平, 田中栄二 :
Smad3リン酸化阻害剤を用いた瘢痕組織形成抑制法の開発,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 天知良太, 渡邉佳一郎, 日浅雅博, 安倍正博, 松本俊夫, 田中栄二 :
酸性環境が骨髄腫細胞の破骨細胞活性に及ぼす影響,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 森博世, 木内奈央, 川合暢彦, 内田玲子, 川上恵実, 石田竜弘, 田中栄二 :
カチオン性リポソームを用いたRNA干渉法による骨格筋量制御効果の検討,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 佐藤南, 永田久美子, 中村竜也, 堀内信也, 黒田晋吾, 田中栄二 :
低出力超音波照射によって滑膜細胞に生じるシグナル伝達経路の解明,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. Shingo Kuroda, KHALIUNAA GANZORIG, Yuichi Maeda, MANSJUR KARIMA QURNIA, Kumiko Nagata and Eiji Tanaka :
Effect of LIPUS on bone remodeling around titanium and stainless steel miniscrew implants,
第72回日本矯正歯科学会大会プログラム・抄録集, Oct. 2013. 黒田晋吾, 塩田智子, 渡邉哲平, 七條なつ子, GANZORIG KHALIUNAA, 田中栄二 :
下顎側方偏位症例の診断と治療における三次元顔面形態計測の応用,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 中嶋昭, 田中栄二, 前野正夫, Charles F Shuler, 清水典佳 :
二次口蓋癒合時におけるTβRsを介したTGF-β signaling pathwayの解明,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 井上雅秀, 黒田晋吾, 渡邉佳一郎, 七條なつ子, 荒古江圭嗣, 上田寛治, 田中栄二 :
歯科矯正用アンカースクリューの直径，埋入角度および荷重方向の違いが周囲骨組織内応力分布へ及ぼす影響,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 川合暢彦, 平坂勝也, 七條なつ子, 塩田智子, 森博世, 木内奈央, 二川健, 田中栄二 :
抗ユビキチン化ペプチドによる骨格筋萎縮抑制法の開発,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 木内奈央, 堀内信也, 高原一菜, 石本恭子, 泰江章博, 黒田晋吾, 田中栄二 :
外鼻形態に対するnasal stent付きホッツ型口蓋床の効果に関する検討,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 堀内信也, 湯本浩通, 木村智子, 天知良太, 金南希, 田中栄二 :
パルス式超音波歯ブラシがStreptococcus mutansのBiofilmに及ぼす影響,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 岩浅亮彦, 石丸直澄, 井澤俊, 徳永律子, 工藤保誠, 田中栄二 :
アロマターゼ遺伝子欠損マウスにおけるシェーグレン症候群様病変と肥満との関連,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 渡邉佳一郎, 黒田晋吾, 森浩喜, 田中栄二 :
歯科矯正用アンカースクリューを用いて治療した成長期の骨格性II級前歯部開咬症例,
第72回日本矯正歯科学会大会プログラム・抄録集, 2013年10月. 前田有一, 黒田晋吾, Wazen Rima, GANZORIG KHALIUNAA, KARIMA QURNIA MANSJUR, Nanci Antonio, 田中栄二 :
上顎洞への歯の移動は安全か-マウス実験的歯の移動モデルを用いた検討-,
第72回日本矯正歯科学会大会プログラム・抄録集, 316, 2013年10月. 田中栄二 :
顎関節症患者の矯正治療後の長期安定性．第72回日本矯正歯科学会大会臨床セミナー1(より良い治療結果を求めて),
第72回日本矯正歯科学会大会プログラム・抄録集, 99, 2013年10月. 川合暢彦, 平坂勝也, 塩田智子, 越智ありさ, 安倍知紀, 真板綾子, 近藤茂忠, 田中栄二, 二川健 :
アテロコラーゲンを担体とした抗ユビキチン化ペプチドによる骨格筋萎縮抑制,
日本宇宙生物科学会第27回大会, 2013年9月. 高原一菜, 三宅雅人, 野村明利, 小倉淳, 親泊美帆, 森智子, 宮本千伸, 三浦直子, 津川和江, 田中栄二, 森和俊, 親泊政一 :
軟骨異形成症の原因である変異型FGFR3は小胞体ストレスを介して軟骨細胞のアポトーシスを誘導する,
2013年9月. 高原一菜, 三宅雅人, 野村明利, 小倉淳, 親泊美帆, 森智子, 宮本千伸, 三浦直子, 津川和江, 田中栄二, 森和俊, 親泊政一 :
小胞体ストレス応答伝達タンパク質ATF6-alphaとATF6-betaの代謝における役割,
第86回日本生化学会大会, 2013年9月. 井澤俊, 森浩喜, 堀内信也, 川合暢彦, 田中栄二 :
ブタ下顎頭軟骨および関節窩軟骨の動的粘弾性特性解析,
日本顎関節学会雑誌, Vol.25, No.Supplement, 84, 2013年7月. 森浩喜, 渡邉佳一郎, 内田玲子, 井澤俊, 黒田晋吾, 森仁志, 田中栄二 :
圧迫骨短縮術を施術した，エナメル質形成不全を伴う骨格性開咬の一治療例,
第56回中·四国矯正歯科学会大会, 2013年7月. 佐藤南, 石本恭子, 渡邉哲平, 木内奈央, 川合暢彦, 黒田晋吾, 田中栄二 :
三次元形態計測装置を用いた顔面非対称の定量的評価,
第56回中·四国矯正歯科学会大会, 2013年7月. 七條なつ子, 黒田晋吾, 井上雅秀, GANZORIG KHALIUNAA, 泰江章博, 堀内信也, 田中栄二 :
歯科矯正用アンカースクリューの撤去時トルクの評価,
第56回中·四国矯正歯科学会大会, 2013年7月. 堀内信也, 泰江章博, 川合暢彦, 黒田晋吾, 宮本洋二, 田中栄二 :
先端巨大症に起因した骨格性下顎前突症に対し舌縮小術を併用して外科的矯正治療を行った1例,
第23回日本顎変形症学会大会, 2013年6月. 阿部直樹, 黒田晋吾, 古谷昌裕, 田中栄二 :
顔認証システムを用いた顎矯正手術後の顔貌予測システムの精度検定,
第23回日本顎変形症学会大会, 2013年6月. 岩浅亮彦, 近藤智之, 黒澤実愛, 新垣理恵子, 山田安希子, 田中栄二, 工藤保誠, 石丸直澄 :
アロマターゼ遺伝子欠損マウスにおける肥満とシェーグレン症候群様病変との関連,
第102回日本病理学会, 2013年6月. 泰江章博, 堀内信也, 黒田晋吾, 大庭康雄, 高橋巧, 田中栄二 :
軟口蓋裂を伴う多数歯欠損症に対し集学的治療を行った1例,
第37回日本口蓋裂学会総会・学術集会, 2013年5月. Ryota Amachi, Keiichiro Watanabe, Shiroh Fujii, T Harada, H Miki, S Nakamura, A Oda, Masahiro Hiasa, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
An acdic milieu confers the resistance to TRAIL in myeloma cells through the PI3K-Akt-mediated epigenetic down-regulation of the TRAIL receptor DR4,
International Bone and Mineral Society 2013, May 2013. Keiichiro Watanabe, Masahiro Abe, H Mori, Ryota Amachi, Masahiro Hiasa, T Harada, Shiroh Fujii, S Nakamura, H Miki, K Kagawa, I Endo, Eiji Tanaka and Toshio Matsumoto :
Induction of cathepsin K induce bone formation in myeloma osteolytic lesions,
International Bone and Mineral Society 2013, May 2013. Ryota Amachi, Keiichiro Watanabe, Shiroh Fujii, T Harada, H Miki, S Nakamura, A Oda, Masahiro Hiasa, Eiji Tanaka, Toshio Matsumoto and Masahiro Abe :
An acdic milieu suppresses histone acetylation in myeloma cells to down-regulate the TRAIL receptor DR4 expression,
14th International Myeloma Workshop, Apr. 2013. Keiichiro Watanabe, Masahiro Abe, Ryota Amachi, Masahiro Hiasa, T Harada, Shiroh Fujii, S Nakamura, H Miki, K Kagawa, I Endo, Eiji Tanaka and Toshio Matsumoto :
Induction of bone formation in myeloma osteolytic lesions by cathepsin K inhibition,
14th International Myeloma Workshop, Apr. 2013. 竹内久裕, 石川輝明, 松本文博, 田中栄二, 中野雅德, 松香芳三 :
徳島大学病院における顎関節症患者の特徴に関する調査 ―男女比,年齢構成と受診期間―,
補綴若手研究会, 2013年3月. 井戸裕奨, 野崎一徳, 内藤尚, 松本健志, 田中栄二, 田中正夫 :
持続的な噛みしめ時における顎関節円板及び後部結合組織の力学解析,
日本機械学会関西支部第88期定時総会・講演会, 2013年3月. 高原一菜, 伊藤太二, 森智子, ロバートゼング, 船橋茉莉, 宮本千伸, 香川聖子, 三宅雅人, 親泊美帆, 津川和江, 田中栄二, 森和俊, 親泊政一 :
DSS誘発性大腸炎モデルを用いたATF6αとATF6βの機能解析,
第85回日本生化学会大会, 2012年12月. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka :
Candidate gene analysis in patients with tooth agenesis,
第60回国際歯科研究学会日本部会総会・学術大会, Dec. 2012. Chikako Takeda, Akihiro Yasue, Naoko Yoneda, Teppei Watanabe and Eiji Tanaka :
Inhibitory effects of Smad3 phosphorylation on wound repair,
第60回国際歯科研究学会日本部会総会・学術大会, Dec. 2012. Yuichi Maeda, Shingo Kuroda, KHALIUNAA GANZORIG, Rima Wazen, Pierre Moffat, Antonio Nanci and Eiji Tanaka :
Miniscrew anchorage enhances the quality of orthodontic treatment,
第60回国際歯科研究学会日本部会総会・学術大会, Dec. 2012. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yasusei Kudo and Naozumi Ishimaru :
The dysfunction of the aromatase worsens the pathogenesis of Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Dec. 2012. 岩浅亮彦, 木内奈央, 永田久美子, 堀内信也, 田中栄二 :
インプラント固定を用いて垂直的被蓋の改善を行った顎関節症を伴う骨格性開咬の治療例,
日本顎関節学会雑誌, Vol.24, No.Suppl., 127, 2012年11月.

(キーワード): *顎関節機能不全症候群(合併症,診断,治療) / *咬合 / 骨格 / *歯科インプラント / *歯牙計測法 / *開咬(合併症,診断,治療) / *歯科矯正用固定源埋込み / *オーバーバイト / ヒト / 青年期(13~18) / 女 / 歯学

清家卓也, 中西秀樹, 田中栄二 :
顎裂骨移植における骨膜移植の併用,
第30回日本頭蓋顎顔面外科学会学術集会, 2012年11月. 阿部直樹, 渡邉佳一郎, 黒田晋吾, 田中栄二 :
顔認証システムを用いた顎矯正手術後の顔貌予測システムの開発,
第30回日本頭蓋顎顔面外科学会学術大会, 2012年11月. 渡邉佳一郎, 黒田晋吾, 中西秀樹, 田中栄二 :
機能的矯正装置による顎整形的治療を行ったHemifacial microsomiaの長期観察例,
第30回日本頭蓋顎顔面外科学会学術大会, 2012年11月. 井戸裕奨, 野崎一徳, 内藤尚, 松本健志, 田中栄二, 田中正夫 :
クレンチング時に関節円板に生じる応力・変位の咬合の条件による違い,
日本顎口腔機能学会第49回学術大会, 2012年10月. Ryota Amachi, Masahiro Abe, Keiichiro Watanabe, Masahiro Hiasa, Eiji Tanaka and Toshio Matsumoto :
An acidic milieu suppresses DR4 editing and induces p22 c-FLIP to cause myeloma resistance to TRAIL,
第74回日本血液学会学術集会, Oct. 2012. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Keiichiro Watanabe, Teppei Watanabe, Naoko Yoneda, Shinya Horiuchi and Eiji Tanaka :
Msx1 gene analysis in non-syndromic tooth agenesis,
第71回日本矯正歯科学会大会プログラム・抄録集, 301, Sep. 2012. 黒田晋吾, 黒田康子, 冨田優子, 田中栄二 :
下顎頭の著しい吸収を伴うII級前歯部開咬症例における保存的矯正治療の長期安定性,
第71回日本矯正歯科学会大会プログラム・抄録集, 281, 2012年9月. 米田尚子, 泰江章博, 渡邉哲平, ミツイアカギシルビアナオミ, 田中栄二 :
核酸医薬からの瘢痕組織形成抑制アプローチ,
第71回日本矯正歯科学会大会プログラム・抄録集, 237, 2012年9月. 木内奈央, 石本恭子, 大浦徳永律子律子, 内田玲子, 岩浅亮彦, 高橋巧, 堀内信也, 黒田晋吾, 田中栄二 :
外鼻形態に対するnasal stent付きホッツ型口蓋床の効果に関する検討,
第71回日本矯正歯科学会大会プログラム・抄録集, 237, 2012年9月. 中村竜也, 永田久美子, 桂智子, 藤原慎視, 堀内信也, 黒田晋吾, 田中栄二 :
顎顔面領域における骨治癒に対する低出力超音波パルス照射の効果の検討,
第71回日本矯正歯科学会大会プログラム・抄録集, 222, 2012年9月. 井上雅秀, 黒田晋吾, 渡邉佳一郎, 高原一菜, 森博世, 田中栄二 :
ミニスクリューの埋入時トルクが成功率に及ぼす影響,
第71回日本矯正歯科学会大会プログラム・抄録集, 213, 2012年9月. 渡邉博人, 中嶋昭, 黒田晋吾, 田中栄二, 清水典佳 :
Ti-Nb合金ワイヤーにおけるサードオーダーベンド付与時のモーメント値の評価,
第71回日本矯正歯科学会大会プログラム・抄録集, 188, 2012年9月. 堀内信也, 天知良太, 金南希, 川上恵実, 松本一真, 松田りえ, 日浅雅博, 黒田晋吾, 田中栄二 :
継続的なフッ素供給がS-PRGフィラー含有矯正歯科用接着剤の歯質脱灰抑制効果に及ぼす影響,
第71回日本矯正歯科学会大会プログラム・抄録集, 187, 2012年9月. 渡邉哲平, 泰江章博, 米田尚子, 田中栄二 :
Smad3リン酸化抑制はPHD2発現を誘導しHIF-1 の分解を促進する,
第71回日本矯正歯科学会大会プログラム・抄録集, 174, 2012年9月. 中嶋昭, 前野正夫, 田中栄二, シューラーチャールズ, 清水典佳 :
二次口蓋癒合時におけるTβRIIおよびTβRIIIを介したTGF-β signaling pathwayの解明,
第71回日本矯正歯科学会大会プログラム・抄録集, 172, 2012年9月. 黒田晋吾, WAZEN Rima, 前田有一, GANZORIG KHALIUNAA, NANCI Antonio, 田中栄二 :
Ameloblastinが骨芽細胞活性に及ぼす影響,
第71回日本矯正歯科学会大会プログラム・抄録集, 163, 2012年9月. 永田久美子, 中村竜也, 前田有一, GANZORIG KHALIUNAA, 川合暢彦, 堀内信也, 黒田晋吾, 田中栄二 :
超音波照射は筋損傷後の筋形成を促進する,
第71回日本矯正歯科学会大会プログラム・抄録集, 144, 2012年9月. 渡邉佳一郎, 安倍正博, 天知良太, 日浅雅博, 中村信元, 遠藤逸郎, 森裕史, 田中栄二, 松本俊夫 :
カテプシンK 阻害剤KK1-300-01 は骨髄腫骨病変部の骨破壊を抑制し骨形成を惹起する,
第30回日本骨代謝学会学術大会, 217, 2012年7月. 天知良太, 安倍正博, 渡邉佳一郎, 中村信元, 日浅雅博, 田中栄二, 松本俊夫 :
酸性環境は骨髄腫細胞にDR4 の発現抑制とcFLIP の活性化を惹起しTRAIL に対する抵抗性を獲得させる,
第30回日本骨代謝学会学術集会, 259, 2012年7月. S Su, Kotaro Tanimoto, Y Tanne, N Hirose, T Mitsuyoshi, K Sumi, Eiji Tanaka and Kazuo Tanne :
Effect of enzymatic degradation on frictional coefficient and tissue change in temporomandibular joint.,
Journal of the Japanese Society for the Temporomandibular Joint, No.SUPPLEMENT, Jul. 2012. 森仁志, 渡邉佳一郎, 内田玲子, 堀内信也, 田中栄二 :
口唇裂・口蓋裂患者に対するセミカスタムメイド創内固定型延長器を用いた上顎骨延長後の安定性の検討,
第55回中・四国矯正歯科学会大会, 41, 2012年7月. 泰江章博, 前田有一, 渡邉哲平, 石本恭子, 木内奈央, 田中栄二 :
後戻りにより再治療を行った上顎前突症例,
第55回中・四国矯正歯科学会大会, 30, 2012年7月. 前田有一, 泰江章博, 大浦徳永律子律子, 中村竜也, 渡邉佳一郎, 田中栄二 :
Hypodontiaを伴う二卵性双生児の上顎前突症例,
第55回中・四国矯正歯科学会大会, 24, 2012年7月. 松本一真, 川合暢彦, 堀内信也, 高原一菜, 川上恵実, 日浅雅博, 黒田晋吾, 田中栄二 :
矯正治療により良好な咬合を獲得した軟骨無形成症患者の長期観察例,
第55回中・四国矯正歯科学会大会, 29, 2012年7月. 猪熊健一, 堀内信也, 黒田晋吾, 田中栄二 :
中性次亜塩素酸水が矯正治療患者のカリエスリスクに及ぼす影響,
第55回中・四国矯正歯科学会大会, 46, 2012年7月. 川上清一, 三次正春, 川上映子, 原慎吾, 古木良彦, 川上恵実, 田中栄二 :
先端巨大症に伴う骨格性下顎前突症に対して顎矯正手術を施行した1例-術後の睡眠呼吸障害への対応について-,
第22回日本顎変形症学会総会, 2012年6月. 阿部直樹, 廣田阿佐緒, 町田恵美, 橋川直浩, 田中栄二, 古谷昌裕 :
上下顎移動術に伴う気道の変化~側方頭部X線規格写真での検討~,
第22回日本顎変形症学会総会, 2012年6月. 米田尚子, 泰江章博, 渡邉哲平, 田中栄二 :
Smad3遺伝子抑制が瘢痕組織形成に及ぼす影響,
第36回日本口蓋裂学会総会, Vol.37, No.2, 141, 2012年5月. 金南希, 天知良太, 堀内信也, 川合暢彦, 藤原慎視, 木内奈央, 黒田晋吾, 田中栄二 :
三次元デジタルモデルを用いた片側性口唇口蓋裂患者の咬合評価に関する検討第二報,
第36回日本口蓋裂学会総会, Vol.37, No.2, 171, 2012年5月. 黒田晋吾, Rima Wazen, Antonio Nanci, 田中栄二 :
DNA,
連携機能を活用した口腔からQOL向上を目指す研究平成23年度研究報告会, 2012年1月. 松本一真, 新垣理恵子, 山田安希子, 日浅雅博, 大浦徳永律子律子, 岩浅亮彦, 田中栄二, 林良夫, 石丸直澄 :
Hyperfunctions of osteoclasts in pathogenesis of rheumatoid arthritis in MRL/lpr mice.,
第40回日本免疫学会学術集会, 2011年11月. Ritsuko 徳永律子 Oura, Rieko Arakaki, Masahiro Hiasa, Akiko Yamada, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
In vivo T cell apoptosis via interaction with CD11b+ macrophages in Fas-deficient host.,
Proceedings of the Japanese Society for Immunology, Vol.40, 111, Nov. 2011. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
A critical role of aromatase in the pathogenesis of Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Vol.40, 127, Nov. 2011. 木内誠, 藤澤健司, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 永井宏和, 藤原慎視, 田中栄二, 宮本洋二 :
下顎枝矢状分割骨切り術と下顎枝垂直骨切り術の術後安定性に関する検討,
第59回NPO法人日本口腔科学会中国・四国地方部会, 2011年11月. 黒田晋吾, 中西秀樹, 森山啓司, 田中栄二 :
仮骨延長法を用いた頭蓋骨早期癒合症患者の中顔面低形成及び不正咬合の改善,
第29回日本頭蓋顎顔面外科学会学術大会, 2011年11月. Keiichiro Watanabe, Masahiro Abe, Q Cui, Masahiro Hiasa, M Kawatani, T Harada, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, A Nakano, K Kagawa, K Takeuchi, H Osada, Eiji Tanaka and Toshio Matsumoto :
Targeting an acidic microenvironment by reveromycin A to overcome drug resistance to myeloma cells and ameliorate bone disease.,
第36回日本骨髄腫研究会総会, Nov. 2011. 川合暢彦, 川上恵実, 中村彩花, 木内奈央, 田中栄二 :
筋ジストロフィーモデルマウスにおけるRNA干渉を用いた咀嚼筋機能の回復,
日本顎口腔機能学会第47回学術大会, 2011年10月. Shingo Kuroda, Rima Wazen, Antonio Nanci and Eiji Tanaka :
Gene expression profiling by DNA microarray and histomorphometric analyses of healing bone around nanotextured implants,
連携機能を活用した口腔からQOL向上を目指す研究平成23年度口腔QOLシンポジウム, Oct. 2011. 川上恵実, 堀内信也, 松田りえ, 内田玲子, 黒田晋吾, 宮本洋二, 天真覚, 田中栄二 :
骨格性開咬症に対する下顎骨の反時計方向を伴う外科的下顎骨移動術の長期安定性:15年経過症例,
第70回日本矯正歯科学会学術大会, 322, 2011年10月. 川上恵実, 堀内信也, 松田りえ, 内田玲子, 黒田晋吾, 宮本洋二, 天真覚, 田中栄二 :
骨格性開咬症に対する下顎骨の反時計方向を伴う外科的下顎骨移動術の長期安定性:15年経過症例,
第70回日本矯正歯科学会学術大会, 2011年10月. 永田久美子, 藤原慎視, 中村竜也, 堀内信也, 黒田晋吾, 田中栄二 :
炎症状態下の筋芽細胞に対する低出力超音波照射の影響の検討,
第70回日本矯正歯科学会学術大会, 205, 2011年10月. 渡邉哲平, 泰江章博, 高原一菜, 三井なおみ, 藤原慎視, 川上恵実, 川合暢彦, 田中栄二 :
ぺリオスチンはヒト歯根膜細胞の骨芽細胞様分化を抑制する,
第70回日本矯正歯科学会学術大会プログラム抄録集, 207, 2011年10月. 中村竜也, 藤原慎視, 永田久美子, 塩田智子, 堀内信也, 黒田晋吾, 田中栄二 :
低出力超音波は関節滑膜炎の増殖性炎症を抑制する,
第70回日本矯正歯科学会学術大会, 292, 2011年10月. 冨田優子, 黒田晋吾, 桂智子, 石本恭子, 中村彩花, 藤原慎視, 田中栄二 :
片側性口唇口蓋裂児における口蓋形成術前の顎裂の重篤度が顎顔面成長に及ぼす影響,
第70回日本矯正歯科学会学術大会プログラム抄録集, 302, 2011年10月. 黒田晋吾, Rima Wazen, 田中栄二, Antonio Nanci :
ナノ加工チタンインプラント周囲の骨治癒様相に対するDNAマイクロアレイを用いた遺伝発現解析,
第70回日本矯正歯科学会学術大会プログラム抄録集, 225, 2011年10月. 米田尚子, 泰江章博, 渡邉哲平, 森博世, 川上恵実, 木内奈央, 田中栄二 :
Smad3遺伝子抑制が瘢痕組織形成に及ぼす影響,
第70回日本矯正歯科学会大会プログラム・抄録集, 245, 2011年10月. 松本一真, 石丸直澄, 井澤俊, 日浅雅博, 大浦徳永律子律子, 岩浅亮彦, 林良夫, 田中栄二 :
関節リウマチモデルマウスにおける破骨細胞の機能亢進,
日本矯正歯科学会大会プログラム・抄録集, 218, 2011年10月.

(キーワード): *関節リウマチ(実験的); 疾患モデル(動物); *破骨細胞 / マウス; 動物; 歯学

堀内信也, 黒田晋吾, 日浅雅博, 天知良太, 渡邉佳一郎, 川上恵実, 川合暢彦, 田中栄二 :
S-PRGフィラー含有矯正歯科用接着剤の歯質脱灰抑制効果に関する検討,
日本矯正歯科学会大会プログラム・抄録集, 312, 2011年10月.

(キーワード): *歯科矯正装置; *歯科矯正治療; *歯牙接着法; 接着剤; フッ素; *歯牙脱灰(予防) / フィラー / ヒト; 歯学

日浅雅博, 安倍正博, 中野綾子, 竹内恭子, 賀川久美子, 中村信元, 三木浩和, 田中栄二, 淺岡憲三, 矢田健一郎, 松本俊夫 :
Pimキナーゼ阻害による腫瘍進展と骨破壊の抑制,
第73回日本血液学会, 2011年10月. Toshihiro Inubushi, M Miyauchi, A Kawazoe, M Okada, A Min, Y Kudo, A Ishikado, T Makino, Kazuo Tanne, Eiji Tanaka and Takashi Takata :
Molecular mechanisms of inhibitory effects of lactoferrin on LPS-mediated osteoclastogenesis,
59th Annual Meeting of JADR, 64, Oct. 2011. Saika Nakamura, Nobuhiko Kawai, R Sano, Y Ohnuki, Y Saeki, Kazuo Tanne and Eiji Tanaka :
The symptoms of masticatory muscles in Parkinsons disease rat model,
59th Annual Meeting of JADR, 64, Oct. 2011. 高原一菜, 伊藤太二, 森智子, Robert Zeng, 船橋茉莉, 宮本千伸, 香川聖子, 三宅雅人, 親泊美帆, 田中栄二, 森和俊, 親泊政一 :
DSS誘発性大腸炎におけるATF6αとATF6βの役割,
第84回日本生化学会大会, 2011年9月. Masahiro Hiasa, A Nakano, Keiichiro Watanabe, C Qu, T Harada, S Fujii, H Miki, S Nakamura, K Kagawa, K Takeuchi, Eiji Tanaka, Kenzo Asaoka, Shuji Ozaki, Toshio Matsumoto and Masahiro Abe :
Prevention of tumor growth and bone destruction in myeloma by Pim kinase inhibition,
Bone Biology Forum, 19-21st Aug, 2011, Shizuoka., Aug. 2011. 日浅雅博, 安倍正博, 中野綾子, 渡邉佳一郎, 中村信元, 田中栄二, 淺岡憲三, 松本俊夫 :
Pimキナーゼの阻害は骨芽細胞分化を促進し，骨髄腫骨病変の形成と腫瘍進展を抑制する,
日本骨代謝学会学術集会プログラム抄録集, 178, 2011年7月. 渡邉佳一郎, 安倍正博, 川谷誠, 日浅雅博, 中村信元, 田中栄二, 長田裕之, 松本俊夫 :
リベロマイシンAによる酸性環境がもたらす骨髄腫薬剤耐性の克服と骨病変形成の抑制,
日本骨代謝学会学術集会プログラム抄録集, 208, 2011年7月. 松本一真, 石丸直澄, 井澤俊, 日浅雅博, 田中栄二, 林良夫 :
関節リウマチモデルマウスにおける破骨細胞の機能解析,
日本骨代謝学会学術集会プログラム抄録集, 256, 2011年7月. 田中栄二 :
低出力超音波の歯科医療への応用,
日本顎関節学会雑誌, Vol.23, 83, 2011年7月. 松本一真, 石丸直澄, 井澤俊, 大浦徳永律子律子, 岩浅亮彦, 林良夫, 田中栄二 :
関節リウマチ病態における破骨細胞を介したT細胞活性化機構の解析,
日本顎関節学会雑誌, Vol.23, 102, 2011年7月. 中村竜也, 藤原慎視, 永田久美子, 田中栄二 :
低出力超音波が関節滑膜炎に及ぼす影響の検討,
日本顎関節学会雑誌, Vol.23, No.supplement, 103, 2011年7月. 永田久美子, 藤原慎視, 中村竜也, 田中栄二 :
低出力超音波照射が筋芽細胞の増殖・分化に及ぼす影響の検討,
日本顎関節学会雑誌, Vol.23, No.supplement, 105, 2011年7月. 松本文博, 石川輝明, 山村佳子, 竹内久裕, 細木秀彦, 中野雅德, 田中栄二 :
顎関節症外来を受診した顎関節脱臼患者における臨床的検討,
日本顎関節学会雑誌, Vol.23, 113, 2011年7月. 岩浅亮彦, 木内奈央, 堀内信也, 田中栄二 :
骨格性下顎前突症患者の顎矯正手術前後における下顎偏位量と咀嚼運動経路との関連性,
日本顎関節学会雑誌, Vol.23, 119, 2011年7月. 三井なおみ, 泰江章博, 堀内信也, 黒田晋吾, 田中栄二 :
下顎骨の反時計回転を伴う下顎枝矢状分割後の長期安定性に関する検討,
第54回中・四国矯正歯科学会学術大会, 23, 2011年7月. 塩田智子, 藤原慎視, 中村竜也, 桂智子, 田中栄二 :
Ankylosisを伴う歯に対する外科的亜脱臼後の牽引処置について,
第54回中・四国矯正歯科学会学術大会, 14, 2011年7月. 田中栄二 :
ラクトフェリン経口投与による歯周組織破壊の抑制効果,
第2回骨バイオサイエンス研究会, 2011年7月. Eiji Tanaka :
Orthodontic approach to TMJ-osteoarthritis with jaw deformity,
第21回日本顎変形症学会総会・30周年記念国際シンポジウム, Jun. 2011. 森博世, 内田玲子, 泰江章博, 川合暢彦, 中村彩花, ミツイアカギシルビアナオミ, 黒田晋吾, 田中栄二 :
骨格性下顎前突症患者における下顎枝矢状分割術後の咽頭部気道形態の変化,
日本顎変形症学会雑誌, 2011年6月. 阿部直樹, 町田恵美, 廣田阿佐緒, 橋川直浩, 田中栄二, 古谷昌裕 :
下顎枝矢状分割術における術後知覚異常∼CT画像による検討∼,
日本顎変形症学会雑誌, 2011年6月. 松田りえ, 堀内信也, 川上恵実, 阿部直樹, 藤澤健司, 永井宏和, 田中栄二 :
上下顎移動術を施行した骨格性下顎前突症の3治験例上顎骨の回転移動と軟組織変化との関連性,
日本顎変形症学会雑誌, 2011年6月. 内田玲子, 木内奈央, 森博世, 内田大亮, 栗林伸行, 田中栄二 :
下顎骨骨折に対してバイオネータータイプのスプリントを用いて整復した1症例,
第21回日本顎変形症学会, 2011年6月. 黒田晋吾, 冨田優子, 桂智子, 藤原慎視, 田中栄二 :
片側性及び両側性口唇・口蓋裂児の乳幼児期における上顎歯槽部成長の三次元的評価,
第35回日本口蓋裂学会総会, 2011年5月. 松田りえ, 堀内信也, 川上恵実, 阿部直樹, 藤澤健司, 永井宏和, 田中栄二 :
上下顎移動術を施行した骨格性下顎前突症の3治験例上顎骨の回転移動と軟組織変化との関連性,
日本顎変形症学会雑誌, Vol.21, No.2, 128, 2011年5月. 松本一真, 石丸直澄, 新垣理恵子, 山田安希子, 田中栄二, 林良夫 :
関節リウマチ病態における破骨細胞を介したT細胞活性化機構の解析,
第100回日本病理学会学術集会, Vol.100, No.1, 60, 2011年4月. 泰江章博, 米田尚子, 渡邉哲平, 田中栄二 :
Smad3リン酸化阻害の創傷治癒に及ぼす効果,
日本口蓋裂学会雑誌, Vol.36, No.2, 119, 2011年4月. 藤原慎視, 桂智子, 中村竜也, 永田久美子, 塩田智子, 田中栄二 :
二次骨移植術施行時の新規補助療法として用いる低出力超音波パルス照射の効果の検討,
日本口蓋裂学会雑誌, Vol.36, No.2, 120, 2011年4月. 天知良太, 堀内信也, 川合暢彦, 木内奈央, 藤原慎視, 黒田晋吾, 田中栄二 :
三次元デジタルモデルを用いた片側性口唇口蓋裂患者の咬合評価に関する検討,
日本口蓋裂学会雑誌, Vol.36, No.2, 120, 2011年4月. 日浅雅博, 安倍正博, 中野綾子, 渡邉佳一郎, 中村信元, 田中栄二, 淺岡憲三, 松本俊夫 :
Pimキナーゼの阻害は骨芽細胞分化を促進し，骨髄腫骨病変の形成と腫瘍進展を抑制する,
日本骨代謝学会学術集会プログラム抄録集, 178, 2011年.

(キーワード): *癌原遺伝子蛋白質(拮抗物質・阻害物質); *骨芽細胞; *骨疾患(病因,実験的); *骨髄腫(合併症,実験的); 細胞分化; *Protein-Serine-Threonine Kinases(拮抗物質・阻害物質) / *Mouse Pim2 Protein(拮抗物質・阻害物質) / マウス; 動物

渡邉佳一郎, 安倍正博, 川谷誠, 日浅雅博, 中村信元, 田中栄二, 長田裕之, 松本俊夫 :
リベロマイシンAによる酸性環境がもたらす骨髄腫薬剤耐性の克服と骨病変形成の抑制,
日本骨代謝学会学術集会プログラム抄録集, 208, 2011年.

(キーワード): *Pyrans; *Spiro Compounds; *骨疾患; *骨髄腫; *抗腫瘍剤耐性 / *Reveromycin A

松本一真, 石丸直澄, 井澤俊, 日浅雅博, 田中栄二, 林良夫 :
関節リウマチモデルマウスにおける破骨細胞の機能解析,
日本骨代謝学会学術集会プログラム抄録集, 256, 2011年.

(キーワード): *関節リウマチ(実験的); 疾患モデル(動物); *破骨細胞 / マウス; 動物; 歯学

渡邉佳一郎, 安倍正博, Cui Qu, Kawatani Makoto, 日浅雅博, Nakano Ayako, Jinno Tadashi, Harada Takeshi, 藤井志朗, 中村信元, Miki Hirokazu, 賀川久美子, 竹内恭子, 尾崎修治, 田中栄二, Osada Hiroyuki, 松本俊夫 :
Reveromycin A prevents bone destruction and suppresses tumor growth in myeloma,
第72回日本血液学会, 2010年12月. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Yoshio Hayashi and Eiji Tanaka :
Analysis of osteoclast activation in the pathogenesis of rheumatoid arthritis,
58th JADR, Nov. 2010. Akihiro Yasue, Naoko Yoneda, Teppei Watanabe and Eiji Tanaka :
Effects of the inhibition of Smad3 phosphorylation on wound healing,
58th JADR, Nov. 2010.

(要約): Objectives: The surgical closure of a cleft palate is considered to impair maxillary growth and dento-alveolar development. Transforming growth factor (TGF)-/Smad3 signaling is known to play an important role in wound healing. In our previous in vivo study, Smad3-deficient mice showed the accelerated re-epithelialization and tissue remodeling in the process of palatal wound repair with downregulation of TGF-1, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1 compared with wild-type mice. In this study, to develop a new remedy for palatal wound, we investigated the effect of a Specific Inhibitor of Smad3 (SIS3) which blocks TGF-1/Smad3 signaling through the inhibition of Smad3 phophorylation. Methods: The primary culture was performed for epithelial cells and fibroblasts from murine newborn mice-derived epidermis. The inhibition of Smad3 phosphorylation by SIS3 was verified with western blot analysis in fibroblasts. The effect of SIS3 on epithelial cell chemotaxis was assessed by in vitro migration assay. The SIS3 effect was also examined by three-dimensional collagen gel contraction assay, then -smooth muscle actin (SMA) expression was examined. Moreover, SIS3 was applied onto the mouse palate after creating mucoperiosteal wound. Histological analysis and immunohistochemistry were also performed for TGF-1, MIP-1 and MCP-1 expressions. Results: Smad3 phosphorylation was inhibited by SIS3 treatment in mice fibroblasts derived from newborn epidermis. The epithelial cells treated with SIS3 showed resistance to migration restraint by TGF-1 stimulation. Fibroblasts augmented contraction rate of collagen gels in the presence of TGF-1, whereas the lower ratio was observed in the case of SIS3 treatment and -SMA expression was decreased simultaneously. Scar formation in palate was reduced in the mice treated with SIS3 followed by the inhibitory effect of inflammation as seen the reduced expressions of TGF-1, MCP-1 and MIP-1. Conclusion: It was suggested that SIS3 treatment may be available for controlling wound repair by inhibiting TGF-1/Smad3 signaling.

清家卓也, 中西秀樹, 田中栄二, 森山啓二, 川上慎吾 :
顎裂骨移植における梨状孔∼顎裂の骨形態の重要性∼,
第28回日本頭蓋顎顔面外科学会学術集会, 2010年10月. 渡邉佳一郎, 黒田晋吾, 田中栄二 :
変則型Le Fort II型骨切りを用いて仮骨延長を行ったCrouzon症候群の一症例,
第69回日本矯正歯科学会大会, 2010年10月. 岩渕泰憲, 谷本幸太郎, 本川雅英, 丹根由起, 犬伏俊博, 神谷貴志, 大熊暁, 國松亮, ファンユウチン, 吉岡基子, 道田将彦, 笹本智子, 光吉智美, 田中栄二, 丹根一夫 :
退行性変性を呈する下顎頭軟骨に対する低出力超音波の影響について,
第69回日本矯正歯科学会, 2010年9月. 大浦徳永律子律子, 石丸直澄, 日浅雅博, 松本一真, 林良夫, 田中栄二 :
Fasを介した末梢T細胞維持機構の破綻による関節リウマチ発症機序の解明,
第69回日本矯正歯科学会, 2010年9月. 川上恵実, 木内奈央, 足立太郎, 中村彩花, 川合暢彦, 田中栄二, 野地澄晴 :
特殊加工コラーゲンを単体としたマイオスタチンsiRNA投与による骨格筋量調節法の研究,
第69回日本矯正歯科学会, 2010年9月. 泰江章博, 米田尚子, 渡邉哲平, 田中栄二 :
Smad3遺伝子機能抑制が瘢痕組織形成に及ぼす影響,
第69回日本矯正歯科学会, 2010年9月.

(要約): 【目的】口唇裂・口蓋裂患者における裂隙閉鎖術後の瘢痕組織は，その強い瘢痕鈎縮により上顎歯列弓狭窄をもたらし，矯正治療により獲得した歯列・咬合の長期安定にも影響を及ぼす．Smad3はTGF-βシグナリングの主要な細胞内因子であり，そのノックアウトマウスにおける口蓋創傷治癒過程では，単球浸潤低下に伴う炎症性反応の抑制ならびに再上皮化の促進が生じ，一方で線維芽細胞の筋線維芽細胞への分化抑制，すなわち瘢痕組織形成の抑制が生じることを我々は明らかにしてきた．今回，瘢痕組織形成抑制法の開発を目的として，Smad3遺伝子機能抑制をSmad3リン酸化阻害剤(Specific Inhibitor of Smad3; SIS3)を用いて行い，その瘢痕組織形成に及ぼす影響について検討した．【試料および方法】新生野生型マウス由来上皮細胞ならびに線維芽細胞の初代培養を行い，SIS3を適用後Smad3遺伝子の抑制効果をウエスタンブロット法にて確認した．一方で，TGF-β1添加後の上皮細胞の遊走能ならびに線維芽細胞における炎症関連因子の発現を解析した．さらにin vivo実験系として，SIS3を野生型マウスの口蓋へ投与し口蓋粘膜に創傷を作製後，その治癒過程における形態学的観察，およびTGF-β1，MIP-1α，MCP-1の免疫組織化学的解析を行った．【結果】SIS3を適用した新生野生型マウス由来初代培養細胞において，Smad3機能抑制が確認された．また，TGF-β1添加後の上皮細胞の遊走能抑制効果はSIS3添加後に低下した．線維芽細胞におけるTGF-β1，MCP-1，MIP-1αの発現量もSIS3非添加群と比較し同様に低下した．SIS3導入マウスでは，口蓋における炎症性反応の抑制に伴う瘢痕形成抑制効果が認められた．【結論】TGF-β1/Smad3シグナル伝達経路の遮断は瘢痕形成抑制に有効であることが示唆された．

田中栄二 :
顎関節と矯正治療, --- 変形性顎関節症の発症機序と矯正歯科的なアプローチ ---,
第69回日本矯正歯科学会, 2010年9月. 石本恭子, 岩田武男, 吉本勝彦, 田中栄二 :
前駆脂肪細胞における新規アディポカインD-dopachrome tautomeraseの作用解析,
第69回日本矯正歯科学会, 2010年9月. 日浅雅博, 安倍正博, 中野綾子, 小田明日香, 天羽宏枝, 竹内恭子, 賀川久美子, 中村信元, 三木浩和, 矢田健一郎, 渡邉佳一郎, 尾崎修治, 淺岡憲三, 田中栄二, 松本俊夫 :
Bone marrow stromal cells supress TACE activity in monocytes to induce osteoclastogenesis,
第72回日本血液学会, 2010年9月. 田中栄二 :
顎関節のバイオメカニクス,
顎顔面バイオメカニクス学会, 2010年9月. 石本恭子, 岩田武男, 吉本勝彦, 田中栄二 :
D -dopachrome tautomeraseが脂肪分化に及ぼす影響,
第52回歯科基礎医学会学術大会・総会, 2010年9月. 石本恭子, 岩田武男, 田中栄二, 吉本勝彦 :
新規アディポカインD-dopachrome tautomeraseの抗肥満作用についての検討,
第10回日本内分泌学会四国支部学術集会, 2010年9月. 堀内信也, 日浅雅博, 木内奈央, 泰江章博, 浜田賢一, 淺岡憲三, 田中栄二 :
リン酸亜鉛カルシウムを添加した亜鉛徐放性アパタイトセメントの開発,
日本矯正歯科学会大会プログラム・抄録集, 208, 2010年9月. 森博子, 高原一菜, 阿部直樹, 堀内信也, 田中栄二 :
持続的噛みしめにおける顎関節内応力解析,
日本矯正歯科学会大会プログラム・抄録集, 251, 2010年9月. 松田りえ, 堀内信也, 川上恵実, 内田玲子, 細木秀彦, 森山啓司, 田中栄二 :
先天性リンパ管腫を伴う下顎側方偏位の一治療例,
日本矯正歯科学会大会プログラム・抄録集, 290, 2010年9月. 渡邉哲平, 泰江章博, 米田尚子, 藤原慎視, 田中栄二 :
ペリオスチンはERK経路を介して歯根膜細胞におけるMMPs発現を上昇させる,
日本矯正歯科学会大会プログラム・抄録集, 194, 2010年9月. 藤原慎視, 桂智子, 中村竜也, 永田久美子, 堀内信也, 田中栄二 :
低出力超音波パルスを用いた顎顔面領域の骨治癒促進効果の検討,
日本矯正歯科学会大会プログラム・抄録集, 258, 2010年9月. 竹内久裕, 石川輝明, 松本文博, 鈴木善貴, 細木秀彦, 細木眞紀, 田中栄二, 中野雅德 :
徳島大学病院における長期受診顎関節症患者に関する後ろ向き研究,
第23回一般社団法人日本学関節学会総会・学術大会, 2010年7月. 中村竜也, 藤原慎視, 永田久美子, 堀内信也, 谷本幸太郎, 田中栄二 :
低出力超音波が炎症状態下の関節滑膜に及ぼす影響の検討,
第23回日本顎関節学会総会・学術大会プログラム・抄録集, Vol.22, No.SUPPLEMENT, 136, 2010年7月. 日浅雅博, 安倍正博, 中野綾子, 小田明日香, 天羽宏枝, 竹内恭子, 賀川久美子, 中村信元, 三木浩和, 矢田健一郎, 渡邉佳一郎, 尾崎修治, 淺岡憲三, 田中栄二, 松本俊夫 :
骨髄間質細胞は，単球のTACE活性を抑制し樹状細胞分化を抑制し破骨細胞文化を誘導する,
第28回日本骨代謝学会, 2010年7月. 渡邉佳一郎, 安倍正博, Kawatani Makoto, 日浅雅博, 中村信元, 田中栄二, 長田裕之, 松本俊夫 :
リベロマイシンAは骨髄腫骨破壊病変の形成と腫瘍進展を抑制する,
第28回日本骨代謝学会, 2010年7月. 米田尚子, 日浅雅博, 井上雅秀, 長山智子, 吉田亮彦, 森博世, 藤原慎視, 堀内信也, 田中栄二 :
インプラント固定に関する統計学的研究,
第53回中・四国矯正歯科学会学術大会, 2010年7月. 高原一菜, 川合暢彦, 中村彩花, 川上恵実, 松本一真, 大浦徳永律子律子, 石本恭子, 藤原慎視, 田中栄二 :
徳島大学病院矯正歯科における矯正患者の動向,
第53回中・四国矯正歯科学会学術大会, 2010年7月. 永田久美子, 木内奈央, 中村竜也, 渡邉哲平, 桂智子, 泰江章博, 藤原慎視, 近藤優子, 田中栄二 :
過去15年間に徳島大学病院矯正歯科に来院した口唇裂・口蓋裂患者の臨床統計学的調査,
第53回中・四国矯正歯科学会学術大会, 2010年7月. 内田玲子, 泰江章博, 渡邉佳一郎, 松田りえ, 天地良太, 堀内信也, 大西正人, 高道康宏, 田中栄二 :
徳島大学病院矯正歯科における顎変形症患者の臨床統計学的検討,
第53回中・四国矯正歯科学会学術大会, 2010年7月. 川合暢彦, 中村彩花, 木内奈央, 川上恵実, 松本一真, 高原一菜, 泰江章博, 藤原慎視, 堀内信也, 田中栄二 :
インダイレクトボンディング法を用いた顎顔面骨骨折時の顎間固定装置装着の試み,
第20回日本顎変形症学会総会プログラム・抄録号, Vol.22, No.2, 195, 2010年6月. 木島毅, 鳥飼勝行, 長西裕樹, 錦織なぎ, 大木健作, 渡邉佳一郎, 田中栄二, 森山啓司, 山本真弓, 島崎一夫, 米満郁男, 大村進 :
梨状孔縁骨切・骨延長により中顔面の形態改善を図ったsyndromic craniosynostosisの1例,
第20回日本顎変形症学会総会プログラム・抄録号, Vol.22, No.2, 152, 2010年6月. 桂智子, 藤原慎視, 近藤優子, 堀内信也, 中西秀樹, 田中栄二 :
一卵性双生児の片側性口唇裂・口蓋裂児と非裂児の三次元顎顔面形態比較,
第34回日本口蓋裂学会総会・学術集会, 2010年5月. 大浦徳永律子律子, 石丸直澄, 山田安希子, 新垣理恵子, 田中栄二, 林良夫 :
Fas分子を介したマクロファージによる末梢T細胞の維持機構,
日本病理学会, Vol.99, No.1, 374, 2010年4月. 松本一真, 石丸直澄, 新垣理恵子, 山田安希子, 大浦徳永律子律子, 田中栄二, 林良夫 :
マウス関節炎モデル樹状細胞のRANKL/Fasシグナルを介した免疫抑制効果,
日本病理学会, Vol.99, No.1, 220, 2010年4月. 松本一真, 石丸直澄, 新垣理恵子, 山田安希子, 大浦徳永律子律子, 田中栄二, 林良夫 :
マウス関節炎モデル樹状細胞のRANKL/FASシグナルを介した免疫抑制効果,
日本病理学会会誌, Vol.99, No.1, 220, 2010年4月. 岩渕泰憲, 谷本幸太郎, 犬伏俊博, 丹根由起, 神谷貴志, 国松亮, 光吉智美, 田中栄二, 丹根一夫 :
変形性顎関節症に対する低出力超音波照射の影響,
第7回歯科物理刺激研究会, 2010年3月. EB Rego, T Inubushi, A Kawazoe, Kotaro Tanimoto, M Miyauchi, Eiji Tanaka, Takashi Takata and Kazuo Tanne :
Ultrasound stimulation induces PGE2 synthesis promoting cementoblastic differentiation in vitro and cementum repair in vivo,
第7回歯科物理刺激研究会, Mar. 2010. 藤原慎視, 中村竜也, 永田久美子, 桂智子, 田中栄二 :
LIPUS照射による頭頸部領域の骨治癒促進効果の検討,
第7回歯科物理刺激研究会, 2010年3月. 中村竜也, 藤原慎視, 永田久美子, 桂智子, 谷本幸太郎, 田中栄二 :
低出力超音波による炎症状態下の関節滑膜およびその細胞に対する影響の検討,
第7回歯科物理刺激研究会, 2010年3月. 髙丸菜都美, 玉谷哲也, 内田大亮, 堀内信也, 永井宏和, 田中栄二, 宮本洋二 :
最近，頭を悩ませた臨床症例その5∼片側性下顎頭過成長を伴う顔面非対称症例の治療経験,
四国歯学会第36回例会, 2010年3月. 髙丸菜都美, 玉谷哲也, 内田大亮, 堀内信也, 永井宏和, 田中栄二, 宮本洋二 :
最近，頭を悩ませた臨床症例(その5) 片側性下顎頭過成長を伴う顔面非対称症例の治療経験,
四国歯学会雑誌, Vol.23, No.2, 142, 2010年. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Ritsuko 徳永律子 Oura, Eiji Tanaka and Yoshio Hayashi :
Immunoregulatory effect via RANKL and Fas signaling of dendritic cells in immurine autoimmune arthritis models,
日本免疫学会総会・学術集会, Dec. 2009. Ritsuko 徳永律子 Oura, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Takashi Izawa, Kazuma Matsumoto, Eiji Tanaka and Yoshio Hayashi :
Immune Regulation by Macrophages through cross-talk between Fas and NF-B Signaling,
日本免疫学会総会・学術集会, Dec. 2009. 川合暢彦, 中村彩花, 川上恵実, 木内奈央, 田中栄二 :
咀嚼性刺激の変化がラット咀嚼筋に及ぼす影響-終日咀嚼筋活動および免疫組織染色による検索-,
日本顎口腔機能学会第43回学術大会, 2009年11月. 川上真奈, 村山長, 長崎信一, 上田寛治, 小川大一, 田中栄二, 二川浩樹 :
3テスラMRIを利用した顎関節の三次元シミュレーション用モデルの構築,
第31回日本歯科技工学会学術大会, 2009年11月. 堀内信也, 日浅雅博, 森博子, 浜田賢一, 淺岡憲三, 田中栄二 :
ボンディング前処理剤がセルフエッチングプライマーを用いるダイレクトボンディングに与える影響について,
第68回日本矯正歯科学会学術大会, 2009年11月. 岩渕泰憲, 谷本幸太郎, 田中伸明, 丹根由起, 犬伏俊博, 神谷貴志, 大熊暁, 国松亮, Huang Yu-Ching, 吉岡基子, 尾崎徳継, 笹本智子, 道田将彦, 田中栄二, 丹根一夫 :
下顎頭軟骨細胞に対する低出力超音波(LIPUS)照射の影響について,
第68回日本矯正歯科学会学術大会, 2009年11月. 中村竜也, 藤原慎視, 泰江章博, 桂智子, 犬伏俊博, 谷本幸太郎, 田中栄二 :
低出力超音波は炎症存在下の滑膜細胞のCOX-2発現を抑制する,
第68回日本矯正歯科学会学術大会, 2009年11月. 松本一真, 井澤俊, 大浦徳永律子律子, 林良夫, 田中栄二 :
関節リウマチにおけるRANKL/Fasシグナルを介した骨・軟骨破壊機構の解析,
第68回日本矯正歯科学会学術大会, 2009年11月. 冨田優子, 黒田晋吾, 渡邉哲平, 松田りえ, 田中栄二 :
Hotz型口蓋床を用いた片側性口唇口蓋裂児の上顎歯槽弓形態変化,
第68回日本矯正歯科学会学術大会, 2009年11月. 中村彩花, 川合暢彦, 佐野良太, 木内奈央, 川上恵実, 丹根一夫, 田中栄二 :
ラット咀嚼筋線維の加齢変化に関する免疫組織学的研究,
第68回日本矯正歯科学会学術大会, 2009年11月. 二川浩樹, 村山長, 上田寛治, 小川大一, 長崎信一, 田中栄二 :
MR画像の3次元構築とシミュレーションモデルの作成,
第2回日本口腔検査学会総会・学術大会, 2009年10月. 田中栄二 :
変形性顎関節症に継発する開咬に対する矯正的なアプローチ,
第22回日本顎関節学会総会・学術大会, Vol.21, No.supplement, 2009年7月. 二川浩樹, 村山長, 上田寛治, 小川大一, 長崎信一, 田中栄二 :
高性能MRIを利用した顎関節の三次元シミュレーションシステムの開発,
第22回日本顎関節学会総会・学術大会, 2009年7月. 松本一真, 井澤俊, 田中栄二 :
RANKLシグナルを介した関節リウマチモデルマウスの骨・軟骨破壊機構の解析,
第22回日本顎関節学会総会・学術大会, Vol.21, No.supplement, 117, 2009年7月. 田中栄二 :
よく噛むことは楽しく生きること,
日本臨床矯正歯科医会中四国キャラバン, 2009年7月. 田中栄二 :
顎顔面成長に対する咀嚼の重要性,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 川上恵実, 堀内信也, 松田りえ, 泰江章博, 黒田晋吾, 田中栄二 :
PLLAスクリュー固定による下顎枝矢状分割術を施行した骨格性下顎前突症の一症例-長期観察例-,
第52回中・四国矯正歯科学会大会, 2009年7月. 中村竜也, 藤原慎視, 桂智子, 泰江章博, 田中栄二 :
Dynamic positioner with facebowを用いて治療を行ったアングルⅡ級1類の2症例,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 渡邉佳一郎, 木内奈央, 中村彩花, 川合暢彦, 黒田晋吾, 田中栄二 :
混合歯列期にLe Fort III型骨延長術を行ったCrouzon症候群男児の長期観察例,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 松本一真, 井澤俊, 大浦徳永律子律子, 日浅雅博, 田中栄二 :
Oligodontiaを伴う著しい過蓋咬合に対する包括的治療例,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 松田りえ, 堀内信也, 川上恵実, 森博子, 宮本洋二, 田中栄二 :
上顎縦骨折による咬合不全に対し，急速拡大装置を逆回転することで整復した1症例,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 渡邉哲平, 近藤優子, 堀内信也, 勝瀬昭三郎, 田中栄二 :
Parry-Romberg症候群患者の頭蓋顔面硬組織および軟組織形態の経時的変化,
第52回中・四国矯正歯科学会学術大会, 2009年7月. 田中栄二 :
顎関節症患者に対する矯正歯科治療ー長期経過例ー,
第17回日本成人矯正歯科学会大会, 2009年6月. 藤原慎視, 堀内信也, 近藤優子, 黒田晋吾, 田中栄二 :
臨床指導講演インプラントアンカーを用いた矯正治療,
四国歯学会第35回例会, 2009年6月. 石本恭子, 藤原慎視, 木内奈央, 中村竜也, 渡邉哲平, 渡邉佳一郎, 近藤優子, 黒田晋吾, 田中栄二 :
石本恭子，藤原慎視，木内奈央，中村竜也，渡邉哲平，渡邉佳一郎，近藤優子，黒田晋吾，田中栄二:片側性口唇裂・口蓋裂児の顎裂の重篤度が顎顔面の成長発育に影響を及ぼす,
第33回日本口蓋裂学会総会, 2009年5月. 渡邉佳一郎, 木内奈央, 近藤優子, 中村竜也, 石本恭子, 渡邉哲平, 藤原慎視, 黒田晋吾, 田中栄二 :
5歳時における片側性及び両側性口唇・口蓋裂児の顎顔面形態の比較,
第33回日本口蓋裂学会総会, 2009年5月. 渡邉哲平, 近藤優子, 藤原慎視, 中村竜也, 渡邉佳一郎, 石本恭子, 木内奈央, 黒田晋吾, 田中栄二 :
片側性口唇・口蓋裂児の顎裂の重篤度と上顎骨歯槽幅径の成長変化の関連性,
第33回日本口蓋裂学会総会, 2009年5月. 中村竜也, 藤原慎視, 黒田晋吾, 堀内信也, 井澤俊, 谷本幸太郎, 田中栄二 :
低出力超音波は炎症存在下の滑膜細胞のCOX-2発現を抑制する,
第6回歯科物理刺激研究会, 2009年3月. 犬伏俊博, 田中栄二, レゴエマヌエル, 谷本幸太郎, 宮内睦美, 高田隆, 丹根一夫 :
セメント芽細胞の破歯細胞誘導能に対する低出力超音波照射の影響,
第6回歯科物理刺激研究会, 2009年3月. 谷本幸太郎, 犬伏俊博, 岩渕泰憲, 田中伸明, 丹根一夫, 田中栄二 :
変形性顎関節症に対する低出力超音波治療,
第6回歯科物理刺激研究会, 2009年3月. 白倉麻耶, 谷本圭司, 檜山桂子, 宮内睦美, 高田隆, 田中栄二, 丹根一夫 :
軟骨細胞における低酸素応答遺伝子発現変動,
第31回日本分子生物学会年会, 2008年12月. 井澤俊, 石丸直澄, 新垣理恵子, 大浦徳永律子律子, 田中栄二, 林良夫 :
Analysis of RANKL and Fas signaling through NF-kB in dendritic cell activation in murine autoimmune arthritis models,
日本免疫学会総会・学術集会記録, Vol.38, 176, 2008年12月. 川添亜希, 山野栄三, 宮内睦美, 石角篤, 田中栄二, 牧野武利, 丹根一夫, 高田隆 :
大豆レシチンによるリポソーム化ラクトフェリン経口投与がリポポリサッカライド誘導歯周組織破壊に及ぼす抑制効果,
第3回ラクトフェリンフォーラム, 2008年11月. 田中栄二, 佐野良太, 川合暢彦, 中村彩花, 木内奈央, 藤原慎視, 井澤俊, 堀内信也, 黒田晋吾 :
ラット側頭筋の筋線維性状,
「口腔からQOL向上を目指す連携研究」インターネット発表会, 2008年11月. 白倉麻耶, 谷本圭司, 中村秀明, 檜山桂子, 宮内睦美, 高田隆, 田中栄二, 丹根一夫 :
軟骨細胞における転写因子HIF-1活性化と破骨細胞誘導機構,
第6回がんとハイポキシア研究会, 2008年11月. 大貫芳樹, 川合暢彦, 田中栄二, 丹根一夫, 三枝木泰丈 :
咬合挙上がラット顎筋の咀嚼運動時の筋活動およびサーカディアンリズムに与える影響,
第50回歯科基礎医学会学術大会, 2008年9月. 堀内信也, 日浅雅博, 川上恵実, 藤原慎視, 淺岡憲三, 田中栄二 :
水硬性リン酸亜鉛セメントのアパタイト置換を応用した新しいバイオマテリアルの開発,
第67回日本矯正歯科学会学術大会, 2008年9月. 木内奈央, 川上恵実, 田中栄二 :
アテロコラーゲンを併用したマイオスタチン特異的RNA干渉法による骨格筋量の調節,
第67回日本矯正歯科学会学術大会, 2008年9月. 佐野良太, 川合暢彦, 中村彩花, 上田宏, 田中栄二, 丹根一夫 :
粉末飼料飼育ラットの終日咀嚼筋活動様相,
第67回日本矯正歯科学会学術大会, 2008年9月. 犬伏俊博, レゴエマヌエルブラガ, 田中栄二, 山野栄三, 川添亜希, 宮内睦美, 高田隆, 丹根一夫 :
過度の力による実験的歯根吸収に対する低出力超音波の抑制効果,
第67回日本矯正歯科学会学術大会, 2008年9月. 井澤俊, 林良夫, 田中栄二 :
RANKLシグナルを介した関節リウマチにおける関節骨・軟骨破壊機構の解析,
第67回日本矯正歯科学会学術大会, 2008年9月. 田中栄二 :
顎関節症状を有する患者の矯正歯科治療, --- 臨床セミナー2 「安全有効な矯正歯科治療のために」 ---,
第67回日本矯正歯科学会学術大会, 2008年9月. 岩渕泰憲, 田中栄二, 川添亜希, 神谷貴志, 川合暢彦, 谷本幸太郎, 丹根一夫 :
下顎頭軟骨の動的剪断特性の異方性,
第21回日本顎関節学会総会・学術大会, 2008年7月. 神谷貴志, 谷本幸太郎, 田中伸明, 丹根由起, 田中栄二, 丹根一夫 :
顎関節表層のSZPとリン脂質との相互作用,
第21回日本顎関節学会総会・学術大会, 2008年7月. 白倉麻耶, 谷本圭司, 田中栄二, 田中伸明, 谷本幸太郎, 丹根一夫 :
軟骨分化過程におけるhypoxia-inducible factor-1標的遺伝子発現,
第21回日本顎関節学会総会・学術大会, 2008年7月. 川添亜希, 田中栄二, 河野信也, 丹根一夫 :
上顎小臼歯先天欠損部に下顎小臼歯の移植を行った切端咬合の矯正歯科治療例,
第51回中・四国矯正歯科学会学術大会, 2008年7月. 北瀬由紀子, 堀内信也, 井澤俊, 田中栄二 :
ハイプルチンキャップを併用した仮骨延長法による上顎骨前方移動を行った両側性唇顎口蓋裂患者の一例,
第51回中・四国矯正歯科学会学術大会, 2008年7月. 藤原慎視, 北瀬由紀子, 高橋巧, 堀内信也, 田中栄二 :
顎裂幅狭小化のための二次的骨移植前に歯槽骨の仮骨延長術を行った2症例,
第51回中・四国矯正歯科学会学術大会, 2008年7月. 近藤優子, 神野恵, 塩屋園敦, 北瀬由紀子, 堀内信也, 高橋巧, 田中栄二 :
過去10年間に徳島大学病院矯正歯科に来院した顎顔面骨骨折患者の実態調査,
第51回中・四国矯正歯科学会学術大会, 2008年7月. 大浦徳永律子律子, 高橋巧, 田中栄二 :
インプラントアンカーを用いて治療した下顎大臼歯の著しい近心傾斜を伴う2症例,
第51回中・四国矯正歯科学会学術大会, 2008年7月. 田中栄二 :
安全有効な矯正歯科治療を目指した臨床と研究,
四国歯学会第33回例会・第27回総会, 2008年6月. 太田耕司, 小野重弘, 瀧雅行, 水田邦子, 二宮嘉昭, 東森秀年, 宮内美和, 武知正晃, 柄なつみ, 田中栄二, 丹根一夫, 杉山勝, 鎌田伸之 :
下顎枝矢状分割骨切り術のスクリュー，プレート固定におけるコントラアングルスクリュードライバーシステムの応用,
第18回日本顎変形症学会, 2008年6月. 植木雅士, 長谷川拓郎, 尾崎徳継, 田中伸明, 国松亮, 田中栄二, 丹根一夫 :
広島大学病院矯正歯科における口唇裂・口蓋裂患者の統計学的調査,
第32回日本口蓋裂学会総会, 2008年5月. 廣瀬尚人, 田中栄二, 長谷川拓郎, 鎌田伸之, 丹根一夫 :
仮骨延長術によって上顎部の後退を改善した片側性口唇裂・口蓋裂の1症例,
第32回日本口蓋裂学会総会, 2008年5月. 西美香, 當麻愉衣子, 筒井啓介, 加来真人, 田中栄二, 宮本義洋, 林堂安貴, 岡本哲治, 丹根一夫 :
広島大学病院矯正歯科における顎裂部への自家腸骨海綿骨移植を受けた口唇裂・口蓋裂患者の臨床統計的調査,
第32回日本口蓋裂学会総会, 2008年5月. 神野恵, 高橋巧, 大庭康雄, 森山啓司, 田中栄二 :
Smad3ノックアウトマウスを用いた口蓋粘膜における創傷治癒解析-第2報-,
第32回日本口蓋裂学会総会, 2008年5月. 山野栄三, 宮内睦美, 石角篤, 田中栄二, 水道裕久, 今中宏真, 牧野武利, 丹根一夫, 高田隆 :
リポポリサッカライド誘導歯周組織破壊に及ぼすリポソーム化ラクトフェリン経口投与の抑制効果第3報:骨芽細胞による破骨細胞形成に及ぼすラクトフェリンの抑制効果について,
第51回日本歯周病学会春季学術大会, 2008年4月. 川添亜希, 山野栄三, 宮内睦美, 田中栄二, 石角篤, 水道裕久, 今中宏真, 牧野武利, 丹根一夫, 高田隆 :
骨芽細胞による破骨細胞形成に及ぼすラクトフェリンの抑制効果について,
第51回日本歯周病学会春季学術大会, 2008年4月.

研究会・報告書

西田真衣, 夏霖泽, Khurel-Ochir Tsendsuren, 加納史也, 田中栄二, 山本朗仁 :
The therapeutic effect of soluble sialic acid-recognizing immunoglobulin-like lectin 9 on the temporomandibular joint arthritis,
2023年度骨・筋とCaクラスター・ミニリトリート, 2024年2月. Eiji Tanaka and N. Suda :
Typodont course. Hands-on Seminar.,
Hands-on Seminar. Mongolian National Univesity of Medical Sciences. Aug 14-17, 2023. (Ulaanbaatar, Mongolia), Aug. 2023. Eiji Tanaka :
Integrated Orthodontic Treatment with Temporary Anchorage Device.,
Lecture and Hands-on Seminar. Mongolian National Univesity of Medical Sciences. Aug 13, 2023. (Ulaanbaartar, Mongolia), Aug. 2023. 保坂啓一, 渡邉佳一郎, 田中栄二, 田代浩史 :
CRインジェクションモールディング法導入セミナー,
ASO International Inc., 2023年8月. 田中栄二 :
矯正歯科臨床における医療安全―デジタル歯科医療に向けてー,
香川県保険医協会・医療安全セミナー, 2023年6月. 保坂啓一, 中島正俊, 渡邉佳一郎, 田中栄二, 鴨居浩平 :
MI時代のコンポジットレジン修復戦略∼SLDPによる接着耐久性向上と，フルデジタルガイドインデックス活用∼．Dental Magazine．モリタ 184:30-33．2023．3月号,
Dental Magazine, 2023年3月. LINZE XIA, Fumiya Kano, Noboru Hashimoto, Eiji Tanaka and Akihito Yamamoto :
Conditioned Medium from M2 Macrophages Alleviates Murine Temporomandibular Joint Osteoarthritis,
第22回日本再生医療学会総会抄録, 73, Mar. 2023. 田中栄二, 日浅雅博 :
歯科矯正用アンカースクリューを用いた安心安全なMTMの実際と注意点,
香川県保険医協会・歯科セミナー, 2022年10月. 田中栄二 :
矯正歯科におけるスクリーニング検査．-スクリーニングを通した治療難易度判定-,
香川県保険医協会・歯科セミナー, 2021年9月. 田中栄二 :
症例に応じた歯科矯正用アンカースクリューの活用,
徳島県歯科医師会講演会, 2021年5月. 田中栄二 :
D-function(歯科用両側性筋電気刺激装置)を利用した咀嚼筋痛への臨床応用．香川県保険医協会・歯科セミナー，令和3年2月23日，高松，マリンパレスさぬき．,
香川県保険医協会・歯科セミナー, 2021年2月. 髙橋哲, 田中栄二 :
外科的矯正治療における難易性の判断を考察する．シンポジウム4モデレーター，,
第30回日本顎変形症学会総会・学術大会, 2020年6月. 田中栄二, 須田直人 :
口唇口蓋裂治療における医科歯科連携を考える．矯正歯科Workshop モデレーター,
第44回日本口蓋裂学会総会・学術大会, 2020年6月. 田中栄二 :
症例に応じた歯科矯正用アンカースクリューの活用,
香川県保険医協会講演会, 2020年3月. 田中栄二 :
変形性顎関節症の発症メカニズムと歯科矯正学的対応,
2019年度第5回研究談話会，神奈川歯科大学学会，令和元年9月4日，横須賀(神奈川歯科大学附属病院)., 2019年9月. Eiji Tanaka :
Temporomandibular Joint disorders in Orthodontics. Special lectures for Department of Orthodontics,,
Aug. 2019. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices. Special lectures for Department of Orthodontics,,
Aug. 2019. 田中栄二 :
下顎頭吸収への矯正歯科的対応,
日本大学歯学部歯科矯正学講座・同門会学術講演会, 2019年3月. 田中栄二 :
認定医の取得，更新を目指す方，また，その指導者へ．,
第77回日本矯正歯科学会学術大会指導者講習会, 2018年10月. Eiji Tanaka :
Diagnosis and tearment of malocclusion.,
General lecture for undergraduate students and international students in Nantong University, Sep. 2018. 田中栄二 :
変形性顎関節症の発現メカニズムと歯科矯正学的対応,
東京歯科大学第438回大学院セミナー, 2018年9月. 田中栄二 :
歯科矯正学学生講義「Orthodontic treatment for skeletal and dentoalveolar open bite」,
広島大学歯学部, 2018年5月. Takashi Izawa, Rieko Arakaki, Eiji Tanaka and Naozumi Ishimaru :
Crosstalk between cytokine RANKL and AhR signaling in osteoclasts controls bone homeostasis,
Gordon Research Seminar; "Bones and Teeth" Translating Mechanisms of Bone Formation and Repair, Jan. 2018.

(キーワード): 破骨細胞 (osteoclast) / RANKL (RANKL)

田中栄二 :
変形性顎関節症の発症メカニズムと歯科矯正学的対応,
第9回木真会定期講演会, 2017年2月. 川合暢彦, 堀内信也, 泰江章博, 篠原丈裕, 白井愛実, 田中栄二 :
外科的矯正治療への歯科矯正用アンカースクリューの導入に関する調査,
日本歯科矯正用アンカースクリュー研究会第1回学術大会, 2016年10月. Islamy Rahma Hutami, Takashi Izawa, Hiroki Mori, Akihiko Iwasa, Takehiro Shinohara, Akiko Mino and Eiji Tanaka :
Fas/S1P system controls subchondral bone remodeling of the temporomandibular joint in autoimmune arthritic mice.,
2016 Tokushima Bioscience Retreat, Sep. 2016. Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino-Oka, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Correction: Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.,
PLoS ONE, Vol.11, No.8, e0162032, Aug. 2016.

(要約): [This corrects the article DOI: 10.1371/journal.pone.0154107.].
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0162032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27560140; ● Search Scopus @ Elsevier (PMID): 27560140; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0162032

(DOI: 10.1371/journal.pone.0162032, PubMed: 27560140) Takashi Izawa, Hiroki Mori, Takehiro Shinohara, Akiko Mino, Islamy Rahma Hutami, Akihiko Iwasa and Eiji Tanaka :
Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis,
13th Meeting of Bone Biology Forum, Aug. 2016. 田中栄二 :
若手口腔外科医のための外科的矯正治療解説―上顎骨移動術の診断・治療計画・術式―．,
日本顎変形症学会第12回教育研修会モデレーター，第26回日本顎変形症学会総会・学術大会, 2016年6月. 井澤俊, 森浩喜, 田中栄二 :
S1P/Smad3シグナルを介した顎関節における変形性関節症の病態解明,
第7回骨バイオサイエンス研究会, 2016年6月. T El-Bialy and Eiji Tanaka :
Therapeutic Ultrasound in Dentofacial Regeneration and Tissue Engineering,
Chair persons of Session Syposium, Mar. 2016. 川合暢彦, 二川健, 田中栄二 :
抗ユビキチン化ペプチドによる骨格筋萎縮抑制,
2016年3月. 泰江章博, 田中栄二 :
ゲノム編集技術を用いたマウス1細胞期胚における遺伝子変異導入,
平成27年度革新的特色研究シンポジウム「エピゲノムと臓器ネットワークで迫る次世代糖尿病研究」, 2016年2月. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices and enhancement of their initial stability,
Special presentation for the Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Dec. 2015. 田中栄二 :
日本矯正歯科学会指導医の更新申請の進め方,
ラウンドテーブルディスカッション(RTD)モデレータ, 2015年11月. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices,
Orthodontic lecture in Mahasaraswati Denpasar University Fuculty of Dentistry, Nov. 2015. Eiji Tanaka :
Integrated orthodontic treatment by use of temporary anchorage devices and enhancement of their initial stability,
Seminar in Mongolian Orthodontists in Mongolian National University of Medical Sciences, July 8, 2015, Ulanbaatar, Mongolia., Jul. 2015. 田中栄二 :
歯科矯正学学生講義「Orthodontic treatment for skeletal and dentoalveolar open bite」,
広島大学歯学部, 2015年6月. Eiji Tanaka :
Mechanism of temporomandibular joint-osteoarthritis: Aetiology, diagnosis and orthodontic approach.,
Nov. 2014. Eiji Tanaka :
The use of low-intensity ultrasound in dentistry, especially in orthodontics.,
May 2014. 田中栄二 :
歯科医療現場におけるリスクマネージメント,
平成25年度愛媛県歯科医師会医療安全講習会, 2014年2月. Eiji Tanaka :
The use of low-intensity pulsed ultrasound in dentistry,
Special lecture in Yonsei University, January 13th, 2014, Wonju, Korea., Jan. 2014. 天知良太, 安倍正博, 渡邉佳一郎, 賀川久美子, 藤井志朗, 原田武志, 三木浩和, 渡邉佳一郎, 小野明日香, 日浅雅博, 田中栄二, 松本俊夫 :
骨髄腫の酸性環境はTRAIL受容体発現をエピジェネティックに抑制し，TRAIL抵抗性をもたらす,
第20回徳島骨代謝研究会, 2013年11月. 田中栄二 :
開業医が手を出して良い症例，手を出しはいけない症例,
西日本歯科研究会, 2013年11月. 田中栄二 :
矯正歯科におけるスクリーニング検査-スクリーニングを通した治療難易度判定-,
徳島市歯科医師会オープンセミナー, 2013年11月. 泰江章博, ミツイアカギシルビアナオミ, 渡辺崇人, 佐久間哲史, 親泊政一, 山本卓, 野地澄晴, 三戸太郎, 田中栄二 :
TALEN，CRISPR/Casシステムを用いたマウス1細胞期胚における標的遺伝子破壊,
第3回ゲノム編集研究会, 2013年10月. 田中栄二 :
顎顔面領域への低出力超音波の応用とスペインの経済情勢の実態調査報告,
木曜研修会, 2013年10月. 田中栄二 :
歯科矯正学特別講義「顎関節症の矯正治療」,
長崎大学歯学部, 2013年6月. 田中栄二 :
矯正セミナー「顎関節のバイオメカニクス」,
長崎大学歯学部, 2013年6月. 田中栄二 :
基礎臨床フォーラム「顎顔面領域への低出力超音波の応用」,
長崎大学歯学部特別講演会, 2013年6月. 田中栄二 :
顎関節症に対する歯科矯正学的アプローチ,
日本顎関節学会第33回学術講演会, 2013年5月. 田中栄二 :
顎関節症の原因，病態，およびその治療法,
香川県保険医協会医科歯科研究会, 2013年4月. 田中栄二 :
口唇口蓋裂患者の矯正歯科治療の流れ,
大空会(徳島地区)医療講演会, 2013年3月. 田中栄二 :
変形性顎関節症の発症メカニズムと歯科矯正学的対応,
平成24年度松本歯科大学歯科矯正学同門会総会, 2012年11月. Keiichiro Watanabe, Ryota Amachi, Masahiro Hiasa, Shingen Nakamura, Itsuro Endo, Hiroshi Mori, Eiji Tanaka and Toshio Matsumoto :
The cathepsinK inhibitor ONO-KK1-300-01 (ONO-KK1) prevents bone destruction and restores bone formation in myeloma bone lesions,
Bone Seminar, Aug. 2012. 天知良太, 安倍正博, 渡邉佳一郎, 賀川久美子, 藤井志郎, 原田武志, 三木浩和, 中村信元, 小田明日香, 日浅雅博, 田中栄二, 松本俊夫 :
酸環境は骨髄腫細胞のTRAILに対する抵抗性を増強する,
第3回骨バイオサイエンス研究会, 2012年7月. 田中栄二 :
咬合と顎関節症との関わり,
平成24年度愛知学院大学歯学会学生のための講演会, 2012年6月. 田中栄二 :
顎関節症患者に対する矯正歯科治療-長期経過例-,
広島大学歯学部歯科矯正学教室同門会セミナー, 2012年6月. 田中栄二 :
顎関節のバイオメカニクス,
日本大学歯学部歯科矯正学教室講演会, 2012年5月. 堀内信也, 田中栄二 :
S-PRGフィラー含有矯正歯科用接着剤の歯質脱灰抑制効果に関する検討,
第4回界面機能性ガラス研究会 Ver.2, 2011年12月. 市川卓, 村田守, 星野和義, 西恭一, 坂井卓爾, 中島昭, 新井嘉則, 田中栄二 :
顎関節の有限要素モデル構築に関する研究,
第44回(平成23年度)日本大学生産工学部学術講演会, 2011年12月. 日浅雅博, 安倍正博, 中野綾子, 渡邉佳一郎, 竹内恭子, 賀川久美子, 三木浩和, 中村信元, 藤井志朗, 原田武志, 尾崎修治, 田中栄二, 淺岡憲三, 松本俊夫 :
Pimキナーゼの阻害による骨髄腫の進展抑制,
癌と骨病変研究会, 2011年11月. Eiji Tanaka :
Biomechanics of the temporomandibular joint,
Special lecture in Univeristy of Oviedo, Gijon Polytechnic School of Engineering, Sep. 2011. 渡邉佳一郎, 安倍正博, 崔衢, 川谷誠, 日浅雅博, 長田裕之, 田中栄二, 松本俊夫 :
A novel anti-resorptive agent, reveromycin A, ameliorates bone destruction and tumor growth in myeloma,
第2回骨バイオサイエンス研究会, 2011年7月. 堀内信也, 田中栄二 :
S-PRGフィラー含有矯正歯科用接着剤の歯質脱灰抑制効果に関する検討-第2報-,
第3回界面機能性ガラス研究会 Ver.2, 2011年4月.

(キーワード): *歯科矯正装置; *歯科矯正治療; *歯牙接着法; 接着剤; フッ素; *歯牙脱灰(予防) / フィラー / ヒト; 歯学

田中栄二 :
噛むことと食育の大切さ-矯正歯科の立場から,
第4回徳島市歯科医師会市民公開講座, 2010年12月. 堀内信也, 田中栄二 :
S-PRGフィラー含有矯正歯科用接着剤の歯質脱灰抑制効果に関する検討,
第2回界面機能性ガラス研究会 Ver.2, 2010年11月. 日浅雅博, 安倍正博, 中野綾子, 小田明日香, 天羽宏枝, 竹内恭子, 賀川久美子, 中村信元, 三木浩和, 矢田健一郎, 渡邉佳一郎, 尾崎修治, 淺岡憲三, 田中栄二, 松本俊夫 :
骨髄間質細胞は，単球のTACE活性を抑制し樹状細胞分化を抑制し破骨細胞文化を誘導する,
第17回徳島骨代謝研究会, 2010年11月. 田中栄二 :
低出力超音波の歯科治療への応用,
香川デンタルスタディークラブ(KDSC)例会, 2010年10月. 渡邉佳一郎, 安倍正博, 崔衢, 川谷誠, 長田裕之, 田中栄二, 松本俊夫 :
リベロマイシンAの骨髄腫骨病変と腫瘍進展抑制作用,
第1回骨バイオサイエンス研究会, 2010年6月. 二川浩樹, 村山長, 上田寛治, 小川大一, 長崎信一, 田中栄二 :
高性能MRIを利用した顎関節の三次元シミュレーションシステムの開発,
鶴見大学新ハイテクリサーチセンター最終年度報告会公開シンポジウム, 2010年1月. 川上恵実, 木内奈央, 田中栄二, 野地澄晴 :
慢性筋委縮疾患制圧を目指したRNA干渉法を利用した咀嚼筋量制御法の開発研究,
先端歯学スクール2009, 2009年8月. 川上恵実, 足立太郎, 田中栄二, 野地澄晴 :
ナノ粒子によるsiRNAの導入検討法,
こころの健康科学研究事業(砂田班)リサーチミーティング, 2009年6月.

特許: 渡邉佳一郎, 保坂啓一, 鴨居浩平, 田中栄二 : 歯科治療用インデックス，歯科治療用インデックス固定クリップ及び歯科治療セット, 特願2024-526462 (2023年5月), 特許第PCT/JP2024/016629号. 山本弘昭, 田中栄二, 黒田晋吾, 阿部直樹 : 顎変形症術後顔貌予測法及びシステム, 特願5883816 (2016年2月), 特許第2013-047559号. 上田寛治, 川岡拓司, 荒古江圭嗣, 田中栄二, 黒田晋吾 : スクリューインプラント, 特願2013-055917 (2013年3月), 特開2014-180366, 特許第5904963号 (2016年3月).
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 治療後に安全にはがせるダイレクトボンディング剤の開発 (研究課題/領域番号: 18K09855 )
低酸素応答遺伝子を介した代謝リプログラミングによる口蓋瘢痕形成抑制への挑戦 (研究課題/領域番号: 17K19758 )
ユビキチン-プロテアソーム系制御による廃用性筋萎縮抑制法の開発 (研究課題/領域番号: 17K11938 )
次世代型高解像度逆遺伝学を駆使した歯牙形成異常関連遺伝子の構造機能相関の解明 (研究課題/領域番号: 16H05551 )
内分泌撹乱物質ダイオキシン受容体AhRによる骨代謝調節機構解明への挑戦 (研究課題/領域番号: 15K15757 )
成長期におけるIGF-1シグナルを介した骨格筋萎縮の機序解明と治療法の開発 (研究課題/領域番号: 26463095 )
頭蓋顎顔面領域高頻度疾患の原因究明から病態発症機序解明への最先端研究戦略 (研究課題/領域番号: 26293436 )
ナノ加工チタンインプラントの臨床応用を目指したメカニカルストレスによる骨形成促進 (研究課題/領域番号: 25463185 )
慢性筋萎縮性疾患に対する核酸創薬の開発研究 (研究課題/領域番号: 25463183 )
グラスアイオノマーの抗齲蝕作用を強化する新規フッ素化合物の検索 (研究課題/領域番号: 25463181 )
骨形成誘導と骨破壊性腫瘍の進展抑制を併せ持つ新たな分子標的薬の開発 (研究課題/領域番号: 25463087 )
関節リウマチにおけるRANKL/Fas シグナルを介した骨・軟骨破壊機構の解明 (研究課題/領域番号: 23659966 )
リン酸カルシウム置換型機能性ベクトルマテリアルに対する細胞応答の検討 (研究課題/領域番号: 22592287 )
TGF-β/Smad3シグナル経路を介した創傷治癒における瘢痕形成抑制法の検討 (研究課題/領域番号: 21592597 )
バイオミネラリゼーションモデルを用いたエナメル質形成不全症(AI)発症機構の解明 (研究課題/領域番号: 20390522 )
歯根膜細胞におけるRhoファミリータンパク質RhoEの細胞骨格制御機構の解明 (研究課題/領域番号: 19592356 )
リン酸カルシウム置換処理による機能性ベクトルマテリアルの開発 (研究課題/領域番号: 19592355 )
顎顔面領域における神経因性疼痛の発生機序解明と炎症性サイトカインの関連性 (研究課題/領域番号: 18592235 )
顎関節再建術に関する研究動向調査 (研究課題/領域番号: 17639020 )
グルタミン酸レセプター拮抗薬による実験的歯の移動時の疼痛抑制 (研究課題/領域番号: 16592045 )
In vivoおよびin vitroでの顎関節円板に対する機械的負荷の影響 (研究課題/領域番号: 14571950 )
患者別計算バイオメカニクスによる顎関節システムの機能評価と顎関節症診断・治療計画 (研究課題/領域番号: 14380402 )
顎関節円板の粘弾性特性解析と円板穿孔の生成メカニズムの解明 (研究課題/領域番号: 12771280 )
顎関節システムの患者個体別計算バイオメカニクスと顎関節症診断への応用 (研究課題/領域番号: 12680830 )
鼻上顎複合体の成長に対する縫合性仮骨延長法の効果 (研究課題/領域番号: 11877361 )
変形性顎関節症における尿中PyrおよびDpyrの診断マーカーとしての有用性 (研究課題/領域番号: 10877337 )
変形性顎関節症における下顎頭吸収機序の解明と治療法の探求 (研究課題/領域番号: 09557176 )
咀嚼運動と中枢神経系・脈管系の形態,機能との関連性 (研究課題/領域番号: 09470471 )
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2024年12月20日更新

専門分野・研究分野: 歯科矯正学 (Orthodontics)
所属学会・所属協会: 日本矯正歯科学会 [2020年4月〜2022年3月])
四国歯学会
国際歯科研究学会日本部会
日本顎関節学会 [2014年7月〜2023年], 新認定医制度委員会副委員長 [2014年7月〜2016年], 渉外委員会委員 [2014年7月〜2020年], 編集査読委員会副委員長 [2014年7月〜2018年], 会則検討委員会副委員長 [2014年7月〜2018年], 理事 [2016年8月〜2020年7月], 専門医制度委員会委員長 [2016年11月〜2018年7月], 総務委員会委員 [2016年11月〜2022年7月], 専門医等試験委員会委員 [2016年11月〜2022年7月], 学会賞選考委員会ポスター発表優秀賞選考委員会委員 [2018年7月〜2020年])
中·四国矯正歯科学会
The Open Dentistry Journal
日本口蓋裂学会
Orthodontics and Craniofacial Research
Journal of Biomechanics
Annals of Biomedical Engineering
日本顎口腔機能学会
Taiwan Orthodontic Society
TheScientificWorldJOURNAL
日本顎変形症学会
日本学術振興会 [2010年12月〜2012年11月])
日本歯科医学会
Conference Papers in Medicine [2012年9月〜2016年9月])
Journal of Research and Practice in Dentistry
Frontiers in Biomechanics
日本矯正歯科学会 [2016年11月〜11月])
全日本歯科学生体育連盟
Journal of Pearldent
日本軟骨代謝学会
日本学術振興会 [2016年12月〜2017年11月])
Frontiers of Oral and Maxillofacial Medicine
Journal of Clinical Medicine
日本頭蓋顎顔面外科学会
委員歴・役員歴: 日本矯正歯科学会 (代議員 [2007年1月〜2022年3月], 卒後教育委員会委員 [2008年4月〜2012年3月], 認定医委員会委員 [2010年4月〜2017年3月], 認定医・専門医制度改革検討委員会委員 [2012年4月〜2016年3月], 理事 [2016年4月〜2020年3月], 認定医委員会委員長 [2018年4月〜2022年3月], 診療ガイドライン委員会委員(令和2年4月1日∼令和4年3月31日) [2020年4月〜2022年3月])
四国歯学会 (理事 [2008年4月〜])
国際歯科研究学会日本部会 (評議員 [2009年1月〜2012年12月], 次期会長選考委員 [2010年3月〜12月], 2012年度次期会長選考委員 [2012年4月〜12月])
日本顎関節学会 (ガイドライン作成委員会委員 [2008年7月〜2012年], 会則検討委員会委員 [2008年7月〜2016年], 評議員 [2007年1月〜2008年12月], 評議員 [2010年7月〜2014年], 編集査読委員会委員 [2012年7月〜2021年], 診療ガイドライン作成委員会委員 [2012年7月〜2016年6月], 代議員(平成26年7月18日∼令和5年7月) [2014年7月〜2023年], 新認定医制度委員会副委員長 [2014年7月〜2016年], 渉外委員会委員 [2014年7月〜2020年], 編集査読委員会副委員長 [2014年7月〜2018年], 会則検討委員会副委員長 [2014年7月〜2018年], 理事 [2016年8月〜2020年7月], 専門医制度委員会委員長 [2016年11月〜2018年7月], 総務委員会委員 [2016年11月〜2022年7月], 専門医等試験委員会委員 [2016年11月〜2022年7月], 学会賞選考委員会ポスター発表優秀賞選考委員会委員 [2018年7月〜2020年])
中·四国矯正歯科学会 (代議員 [2008年4月〜], 学会長 [2016年1月〜2019年12月])
The Open Dentistry Journal (Editorial Board [2007年〜2024年])
日本口蓋裂学会 (第32回日本口蓋裂学会総会・学術集会準備委員長[2008年5月28-29日] [2008年5月〜5月])
Orthodontics and Craniofacial Research (Orthodontics and Craniofacial Research, Editorial Board, 2007.1.~ [2007年1月〜])
Journal of Biomechanics (Board of Editorial Consultants [2009年9月〜])
Annals of Biomedical Engineering (Associate Editors [2009年10月〜])
日本顎口腔機能学会 (評議員 [2011年4月〜], 矯正治療患者の機能評価のガイドライン評価委員会委員 [2010年])
Taiwan Orthodontic Society (Honorary fellow of Taiwan Orthodontic Society [2011年8月〜])
TheScientificWorldJOURNAL (Editorial Board [2011年8月〜2017年6月])
日本顎変形症学会 (評議員 [2012年1月〜2023年6月], 学術委員会委員 [2012年7月〜2023年6月], 認定医制度検討委員会小委員 [2015年1月〜2018年6月], 理事 [2016年7月〜2020年6月], 医療問題検討委員会委員 [2016年7月〜2018年6月])
日本学術振興会 (科学研究費委員会専門委員(平成22年12月1日∼平成24年11月30日) [2010年12月〜2012年11月])
日本歯科医学会 (英文雑誌編集委員会editorial Board委員 [2013年7月〜2020年6月])
Conference Papers in Medicine (Editorial Board (2012.9.-) [2012年9月〜2016年9月])
Journal of Research and Practice in Dentistry (Editorial Board [2013年4月〜2021年3月])
Frontiers in Biomechanics (Editorial Board [2013年5月〜])
日本矯正歯科学会 (第75回日本矯正歯科学会大会長(平成28年11月7日∼9日) [2016年11月〜11月])
全日本歯科学生体育連盟 (第49回大会副会長 [2016年9月〜2017年8月], 理事 [2016年9月〜2023年8月])
Journal of Pearldent (International Board Review Member [2016年4月〜2021年3月])
日本口蓋裂学会 (日本口蓋裂学会評議員 [2017年5月〜])
日本軟骨代謝学会 (日本軟骨代謝学会評議員 [2017年4月〜])
日本学術振興会 (科学研究費委員会専門委員(平成28年12月1日∼平成29年11月30日) [2016年12月〜2017年11月])
Frontiers of Oral and Maxillofacial Medicine (Editorial Board [2020年5月〜])
Journal of Clinical Medicine (Guest Editor [2019年〜2020年])
日本頭蓋顎顔面外科学会 (日本頭蓋顎顔面外科学会代議員 [2022年11月〜])
Journal of Clinical Medicine (Editiorial Board [2022年6月〜])
受賞: 2008年5月, 第32回日本口蓋裂学会総会優秀ポスター賞 (日本口蓋裂学会)
2008年9月, 第67回日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2009年8月, 先端歯学スクール2009，優秀発表賞 (先端歯学スクール2009)
2009年9月, JADR 学術奨励賞, 2009． (国際歯科研究学会)
2009年11月, 第68回日本矯正歯科学会大会優秀発表賞 (日本矯正歯科学会)
2010年, Young Investigator Award, 2010. (2010 ASBMR)
2010年1月, 三木康楽賞 (財団法人三木康楽会)
2010年7月, 88th IADR Travel Award, 2010. (国際歯科研究学会)
2010年9月, Travel Grant Award, 2010. (10th International Conference Cancer-Induced Bone Disease)
2010年9月, 第69回日本矯正歯科学会大会優秀発表賞 (日本矯正歯科学会)
2010年11月, JADR 学術奨励賞, 2010. (国際歯科研究学会・日本部会)
2010年12月, 52nd ASH Travel Award (52nd ASH)
2010年12月, Best Poster Presentation Award (International Joint Symposium on Oral Science)
2011年7月, IOF-ANZBMS Travel Award. (国際歯科研究学会日本部会)
2011年7月, 優秀演題賞 (第29回日本骨代謝学会)
2011年7月, 高得点演題賞 (日本骨代謝学会)
2011年9月, 4. Hiasa M, Nakano A, Watanabe K, Qu C, Harada T, Fujii S, Miki H, Nakamura S, Kagawa K, Takeuchi K, Tanaka E, Asaoka K, Ozaki S, Matsumoto T, Abe M: (米国骨代謝学会)
2011年10月, 2011年度JADR学術奨励賞 (国際歯科研究学会日本部会)
2011年10月, 第70日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2012年, 平成24年度日本顎関節学会学術奨励賞 (日本顎関節学会)
2012年5月, 第36回日本口蓋裂学会総会優秀ポスター賞 (日本口蓋裂学会)
2012年9月, Young Investigator Award, 2012 (ANZBMS)
2012年9月, 第71回日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2012年12月, JADR/Joseph Lister Award.2012 (国際歯科研究学会)
2013年6月, 日本口蓋裂学会優秀論文賞 (日本口蓋裂学会)
2013年10月, Plenary poster & Young Investigator Travel Award (米国骨代謝学会)
2013年10月, 第72日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2013年10月, The 72nd Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award (日本矯正歯科学会)
2014年10月, 第73日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2014年12月, Best Poster Presentation Award. (The 3rd ASEAN Plus and Tokushima Joint International Conference,)
2015年6月, 第25回日本顎変形症学会総会優秀ポスター賞 (日本顎変形症学会)
2015年11月, 第74日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2015年11月, 第74日本矯正歯科学会学術大会 English Presentation Award. (日本矯正歯科学会)
2016年7月, 第29回日本顎関節学会総会・学術大会口演発表大会長賞 (日本顎関節学会)
2016年7月, 第34回日本骨代謝学会学術集会・第3回アジア太平洋骨代謝学会議,Young investigator award. (日本骨代謝学会)
2016年9月, 4. Iwata M, Kuroda Y, Matsumoto K, Shinohara T, Tanaka E. Five-year prognosis of a patient with malocclusion who underwent comprehensive treatment for severe periodontitis. 第102回アメリカ歯周病学会共催日本歯周病学会・日本臨床歯周病学会2016年大会(AAP-JSP/JACPサンディエゴ大会), JSP/JACP ポスターCase Report 部門(デンツプライシロナ賞)優秀賞. (JSP/JACP)
2016年11月, 第75回日本矯正歯科学会大会優秀発表賞 (日本矯正歯科学会)
2016年11月, 第19回日本矯正歯科学会学術奨励賞 (日本矯正歯科学会)
2017年6月, ANZBMS Plenary Poster Award. (Australian and New Zealand Bone and Mineral Society)
2017年10月, 第76回日本矯正歯科学会学術大会優秀発表賞 (academic exhibits competition 部門) (日本矯正歯科学会)
2018年9月, 6th Meeting of Mongolian Association of Orthdontists 優秀ポスター賞 (Mongolian Association of Orthdontists)
2018年11月, 第77回日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2019年2月, the Meritorious Award for the best research project. (Association of Orthodontists (Singapore) Congress,)
2019年6月, 第29回日本顎変形症学会総会・学術大会優秀ポスター賞. (日本顎変形症学会)
2019年7月, 第36回日本骨代謝学会学術集会研究奨励賞. (日本骨代謝学会)
2019年11月, 第78回日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2021年9月, 第83回日本血液学会学術集会優秀ポスター賞 (一般社団法人日本血液学会)
2021年11月, 第80回日本矯正歯科学会学術大会優秀発表賞 (日本矯正歯科学会)
2022年5月, 第47回日本骨髄腫学会学術集会優秀ポスター賞 (日本骨髄腫学会)
2024年4月, 2023年度教養教育賞 (徳島大学)
活動: The Open Dentistry Journal (Editorial Board [2007年〜])
Orthodontics and Craniofacial Research (Editorial Board [2007年〜])
Research Grants Council (RGC) of Hong Kong (External reviewer to assess grants proposal [2007年〜])
Journal of Biomechanics (Board of Editorial Consultants [2009年〜])
Annals of Biomedical Engineering (Associate Editor [2009年〜])
TheScientificWorldJOURNAL (Editorial Board [2011年8月〜])
Taiwan Orthodontic Society (Honorary fellow [2011年8月〜])
Conference Papers in Medicine (Editorial Board [2012年9月〜])
Journal of Dentistry Research (Editorial Board [2013年3月〜])
平成24年5月20日∼6月8日(20日間) A grant in the program Cajastur Fellowship €15,000 for 1.5 month research stay 渡航先:スペイン・オビエド大学・工学部構造力学分野(主任:Alfonso Fernandez Canteli教授) (A grant in the program Cajastur Fellowship [2012年5月〜6月])
The Research Grants Council (RGC), of Hong Kong (External reviewer to assess grants proposal [2007年〜])
日本学術振興会 (科学研究費委員会専門委員 [2013年12月〜2017年11月])
医療系大学間共用試験実施評価機構 (11. 医療系大学間共用試験実施評価機構歯学系CBT実施小委員会委員 [2013年4月〜2016年3月])
第49回全日本歯科学生体育連盟 (大会副会長 [2016年9月〜2017年8月])
全日本歯科学生体育連盟 (理事 [2016年9月〜2017年8月])

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2024年12月22日更新

2024年12月21日更新

Ｊグローバル

Jグローバル最終確認日: 2024/12/21 01:23
氏名（漢字）: 田中栄二
氏名（フリガナ）: タナカエイジ
氏名（英字）: Tanaka Eiji
所属機関: 旧所属広島大学大学院医歯薬学総合研究科(歯) 助教授

リサーチマップ

researchmap最終確認日: 2024/12/22 01:33
氏名（漢字）: 田中栄二
氏名（フリガナ）: タナカエイジ
氏名（英字）: Tanaka Eiji
プロフィール: リサーチマップAPIで取得できませんでした。
登録日時: 2008/12/19 00:00
更新日時: 2024/12/18 10:32
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学位授与機関: 大阪大学
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2024年12月21日更新

研究者番号: 40273693

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2020/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学域), 教授
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(歯学系), 教授
2015/4/1 – 2016/4/1 : 徳島大学, 大学院医歯薬学研究部, 教授
2014/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2011/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2012/4/1 : 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授
2008/4/1 – 2012/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2007/4/1 : 広島大学, 大学院・医歯薬学総合研究科, 准教授
2006/4/1 : 広島大学, 大学院医歯薬学総合研究科, 助教授
2005/4/1 : 広島大学, 大学院・医歯学総合研究科, 助教授
2002/4/1 – 2005/4/1 : 広島大学, 大学院・医歯薬学総合研究科, 助教授
2003/4/1 : 広島大学, 大学院・医歯薬総合研究科, 助教授
2002/4/1 : 広島大学, 大学院・医学歯学薬学総合研究科, 助教授
2001/4/1 : 広島大学, 歯学部, 助教授
2000/4/1 : 広島大学, 歯学部・附属病院, 講師
1998/4/1 – 1999/4/1 : 広島大学, 歯学部附属病院, 講師
1998/4/1 : 広島大学, 歯学部・附属病院, 講師

審査区分/研究分野

研究代表者

医学 / 歯学 / 矯正・小児・社会系歯学
生物系 / 医歯薬学 / 歯学 / 矯正・小児系歯学

研究代表者以外

医学 / 歯学 / 矯正・小児・社会系歯学
生物系 / 医歯薬学 / 歯学 / 矯正・小児系歯学
生物系 / 医歯薬学 / 歯学 / 外科系歯学
複合領域 / 医用生体工学・生体材料学
口腔科学およびその関連分野
小区分57070:成長および発育系歯学関連

キーワード

研究代表者

顎関節円板 / 粘弾性特性 / 機械的負荷 / 円板穿孔 / プロテオグリカン / 応力緩和 / 顎関節 / 変形性顎関節症 / 人工置換 / 再生医工学 / 再建術 / 歯科矯正学 / 創傷治癒 / 口蓋粘膜 / Smad3 / 瘢痕形成 / siRNA / Smad3拮抗薬 / 関節リウマチ / RANKLシグナル / 破骨細胞 / 免疫細胞 / 関節骨破壊 / 樹状細胞 / ゲノム編集 / 遺伝子疾患 / CRISPR/Cas / 非症候性多数歯欠損 / TALEN / 突然変異導入 / 潤滑機能 / 円板培養細胞 / 関節内摩擦 / ヒアルロン酸 / 血小板由来増殖因子 / 培養細胞 / 関節摩擦 / Temporomandibular joint disc / Viscoelastic property / Lubrication / Cultured disc cell / Mechanical load / Joint friction / Hyaluronic acid / PDGF / 中枢神経系 / グルタミン酸 / NMDA受容体 / 疼痛伝達 / MK-801 / セロトニン / 下降性抑制系 / 実験的歯の移動 / Central nerve system / Glutamate / NMDA-receptor / Pain transmission / Serotonin / Descending modulation / 神経因性疼痛 / サイトカイン / 疼痛伝達系 / 行動テスト / 眼窩下神経 / Neuropathic pain / Cytokine / Behavior test / Infraorbital nerve

研究代表者以外

変形性顎関節症 / 下顎頭吸収 / 下顎頭軟骨 / ピリジノリン / デオキシピリジノリン / 生化学診断 / 診断マーカー / 高速液体クロマトグラフィ / 仮骨延長法 / ラット / 骨縫合 / 上顎骨 / 亜鉛 / ハイドロキシアパタイト / 骨形成 / セメント / リン酸亜鉛 / 硝酸カルシウム / 人工骨置換材 / 歯科矯正学 / 歯根膜細胞 / RhoE / 細胞骨格 / RNAi / アテロコラーゲン / メカニカルストレス / エナメル蛋白 / バイオミネラリゼーション / エナメル質形成不全症 / アメロゲニン / 生体材料 / リン酸カルシウム / リン酸亜鉛カルシウム / 創傷治癒 / 口蓋粘膜 / Smad3 / 瘢痕形成 / siRNA / 多発性骨髄腫 / 骨芽細胞 / 間質細胞 / 歯質強化 / フッ素 / 歯科矯正用接着剤 / グラスアイオノマー / 矯正歯科用接着剤 / 骨格筋 / リポソーム / ナノ加工インプラント / マイクコアレイ / マイクロアレイ / LIPUS / 骨治癒 / チタン / インプラント / 骨格筋萎縮 / ユビキチンン-プロテアソーム経路 / IGF-1シグナル / Cbl-b / 機能性ペプチド / ユビキチン-プロテアソーム経路 / 咀嚼 / 咬合 / 機械的負荷 / 求心性刺激 / 中枢神経系 / 大理石病マウス / 咀嚼機能 / 顎顔面形態 / 縫合成長 / 破骨細胞 / 大理石骨病マウス / 骨粗鬆症 / Mastication / Occlusion / Mechanical stimuli / Sensory input / Central nervous system / Osteopetrotic mice / Masticatory muscle activity / 顎関節 / 滑液 / 顎関節内障 / 顎関節病態 / 下顎頭位 / 顎関節負荷 / 関節軟骨 / 軟骨基質タンパク質 / Temporomandibular joint / Osteoarthrosis (OA) / Condylar resorption / Synovial fluid / Condylar cartilage / Mechanical loading / バイオメカニクス / 計算生体力学 / 個体別モデル / Biomechanics / Computational Mechanics / Individual modeling / 個体別モデリング / Individual Modeling / 歯学 / 骨代謝学 / 免疫学 / シグナル伝達 / 骨リモデリング / 病理学 / 細胞・組織 / 歯の発生 / ゲノム編集 / in vivo DNA deletion / In vivo DNA deletion / CRISPR/Casシステム / 蛋白質 / 低酸素応答遺伝子 / 口蓋瘢痕 / 代謝リプログラミング / イオン液体 / 通電剥離 / グラスアイオノマーセメント / ダイレクトボンディング材 / 剥離 / 解体性接着剤

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田中栄二