トップ研究者を探す東アジア・英国での生理活性物質の流域での形成要因と生態影響レベルの比較

東アジア・英国での生理活性物質の流域での形成要因と生態影響レベルの比較

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26257302
研究種目 基盤研究(A)
研究分野 総合系
環境学
環境解析学
放射線・化学物質影響科学
研究機関 京都大学
代表研究者 田中 宏明
研究分担者 中田 典秀
研究分担者 宮川 信一
研究分担者 井原 賢
研究分担者 井口 泰泉
研究分担者 山下 尚之
研究分担者 李 善太
研究分担者 花本 征也
連携研究者 花本 征也
研究協力者 JOHNSON Andrew
研究協力者 PARK Chulhwi
研究協力者 呉 光学
研究協力者 PARK Junwon
研究協力者 ZHANG Han
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2017/4/1)
配分額(合計) 40,690,000 (直接経費 :31,300,000、間接経費 :9,390,000)
配分額(履歴) 2016年度:11,700,000 (直接経費 :9,000,000、間接経費 :2,700,000)
2015年度:11,700,000 (直接経費 :9,000,000、間接経費 :2,700,000)
2014年度:17,290,000 (直接経費 :13,300,000、間接経費 :3,990,000)
キーワード 生理活性
医薬品類
下水
河川
レポータージーンアッセイ
Gタンパク結合受容体(GPCR)
アルカリホスファターゼ融合TGFα切断アッセイ
抗うつ剤受容体アッセイ
化学分析
下水処理
膜分離活性汚泥法
モデル
バイオアッセイ
エストロゲン様作用
TGFα切断アッセイ
生理作用
モデル化
薬理作用
機器分析

研究成果

[雑誌論文] The different fate of antibiotics in the Thames River, UK, and the Katsura River, Japan

Hanamoto, S., Nakada, N., Johnson, AC., Jürgens, MD., Yamashita, N., Tanaka, H. 2018

[雑誌論文] Source estimation of pharmaceuticals based on catchment population and in-stream attenuation in Yodo River watershed, Japan

Hanamoto, S., Nakada, N., Yamashita, N., Tanaka, H. 2018

[雑誌論文] Membrane fouling control and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR

J. Park, N.Yamashita, H.Tanaka 2018

[雑誌論文] 下水,河川水からの医薬品生理活性の検出

井原賢, 張 晗, 花本征也,田中宏明 2018

[雑誌論文] Removal of pharmaceuticals and personal care products by ammonia oxidizing bacteria acclimated in a membrane bioreactor: Contributions of cometabolism and endogenous respiration

Park, J., Yamashita, N., Wu, G., Tanaka, H. 2017

[学会発表] Removal characteristics of pharmaceuticals and personal care products in a membrane bioreactor

Park, J., Yamashita, N., Tanaka, H. 2017

[学会発表] Evaluation of the fate of photoproducts of ketoprofen in urban rivers

Hanamoto S, Hasegawa E, Nakada N, Yamashita N, Tanaka H 2017

[学会発表] 膜分離活性汚泥法における医薬品類の除去特性とメカニズム解明

朴畯遠、山下尚之、田中宏明 2017

[学会発表] Fouling control and biodegradability enhancement of pharmaceuticals and personal care products by coagulation-MBR process

Park, J., Yamashita, N., Tanaka, H. 2017

[学会発表] Fouling reduction and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR process

Park, J., Yamashita, N., Tanaka, H. 2017

[雑誌論文] Removal characteristics of pharmaceuticals and personal care products: Comparison between membrane bioreactor and various biological treatment processes

Park, J., Yamashita, N., Park, C., Shimono, T., Takeuchi, D., Tanaka, H. 2017

[学会発表] "The fate of ketoprofen’s photo transformation products in waste water treatment plant"

E. Hasegawa, S. Hanamoto, N. Nakada, N. Yamashita, H. Tanaka 2017

[学会発表] Detection of physiological activities of pharmaceuticals in river water: Suggestions to prioritization of pharmaceuticals in research involving environmental monitoring and toxicity testing

Masaru Ihara, Han Zhang, Seiya Hanamoto, and Hiroaki Tanaka 2017

[学会発表] Prioritization of main causative β-blockers for physiological activity in UK wastewater

Han Zhang, Masaru Ihara, Seiya Hanamoto, Norihide Nakada, Monika D. Jurgens, Andrew C. Johnson, and Hiroaki Tanaka 2017

[学会発表] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay

Masaru Ihara, Mariko O. Ihara, and Hiroaki Tanaka 2017

[学会発表] Investigation of main G Protein-Coupled Receptor-acting pharmaceuticals to trigger physiological activities in the wastewater of UK by the in vitro TGFα shedding assay

Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA 2017

[学会発表] In vitroアッセイによる下水中の抗うつ薬様物質の生理活性の検出

井原 賢、井原 満理子、加藤 大典、Han Zhang、田中 宏明 2017

[学会発表] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay

Masaru Ihara, Mariko O. Ihara, Hiroaki Tanaka 2017

[学会発表] Prediction and management of emerging chemicals in the water environment

Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Fumiaki OGAWA, Seiya HANAMOTO, Andrew JOHNSON, Monika JÜRGENS 2017

[学会発表] 下水処理水が流入する都市河川におけるケトプロフェンとその光分解産物の濃度変動調査

長谷川英資、花本征也、中田典秀、山下尚之、田中宏明 2016

[学会発表] 河川における医薬品類の底質への移行に関する検討

花本征也、中田典秀、山下尚之、田中宏明 2016

[学会発表] 水生生物への影響が懸念される医薬品:下水・河川水中の医薬品生理活性からの考察

井原賢、花本征也、Zhang Han、田中宏明 2016

[学会発表] Comparison of Physiological Activities of Pharmaceuticals in Primary Effluent of Wastewater Treatment Plant between Japan and UK

Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA 2016

[学会発表] 下水中のエストロゲン様作用、抗エストロゲン作用による複合影響

井原賢、北村友一、Vimal Kumar、Park Chang-Beom、大野満理子、Lee Sang-Jung、山下尚之、宮川信一、井口泰泉、岡本誠一郎、鈴木穣、田中宏明 2015

[学会発表] In vivo vitellogenin expression in male medaka induced by wastewater is determined by the balance between estrogenic and antiestrogenic activities

M. Ihara, T. Kitamura, V. Kumar, C. B. Park, M. O. Ihara, S. J. Lee, N. Yamashita, S. Miyagawa, T. Iguchi, S. Okamoto, Y. Suzuki, and Hiroaki Tanaka 2015

[学会発表] 河川流下過程における医薬品類の減衰:実態把握とメカニズム解明

花本征也、中田典秀、山下尚之、田中宏明 2015

[雑誌論文] Evaluation of Estrogenic Activity of Wastewater: Comparison Among In Vitro ERα Reporter Gene Assay, In Vivo Vitellogenin Induction, and Chemical Analysis

Masaru Ihara, Tomokazu Kitamura, Vimal Kumar, Chang-Beom Park, Mariko O. Ihara, Sang-Jung Lee, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Seiichiro Okamoto, Yutaka Suzuki, and Hiroaki Tanaka 2015

[雑誌論文] Influence of Hydraulic Retention Time, Sludge Retention Time, and Ozonation on the Removal of Free and Conjugated Estrogens in Japanese Activated Sludge Treatment Plants

Kumar, V., Nakada, N., Yamashita, N., Johnson, A.C., Tanaka, H. 2015

[学会発表] 河川水に含まれる医薬品生理活性の測定

井原賢、花本征也、Zhang Han、田中宏明 2015

[学会発表] Detection and Comparison of Physiological Activities of Pharmaceuticals in Secondary Effluent between UK and Japan

Han Zhang, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA 2015

[雑誌論文] The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review.

Vimal Kumar, Andrew C. Johnson, Achim Trubiroha, Jitka Tumova, Masaru Ihara, Roman Grabic, Werner Kloas, Hiroaki Tanaka, Hana Kocour Kroupova. 2015

[学会発表] Detection of physiological activities of pharmaceuticals in river water in Japan

Masaru Ihara, Han Zhang, Seiya Hanamoto, and Hiroaki Tanaka 2015

[雑誌論文] Detection of physiological activities og G protein-coupled receptor-acting pharmaceuticals in wastewater.

Masaru Ihara, Asuka Inoue, Seiya Hanamoto, Han Zhang, Jyunken Aoki, Hiroaki Tanaka. 2015

[学会発表] Fate of endocrine disrupting chemicals and emerging contaminants in the environment and their remediation

Hiroaki TANAKA, Masaru IHARA, Seiya HANAMOTO, Seiichiro OKAMOTO, Andrew JOHNSON, Monika JÜRGENS 2015

[学会発表] Comparison of physiological activities of pharmaceuticals in secondary effluent between UK and Japan

Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA 2015

[学会発表] 河川水からの医薬品生理活性の検出

井原賢、花本征也、Han Zhang、田中宏明 2015

[学会発表] "Mechanistical consideration of natural attenuation of pharmaceuticals and personal care products

Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka 2014

[学会発表] Sorption of pharmaceuticals from river water onto sediment: harnessing river as treatment system in water reuse

Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Hiroaki Tanaka 2014

[学会発表] Natural attenuation of pharmaceuticals and personal care products in Thames River

S. Hanamoto, N. Nakada, M.D. Jürgens, A. C. Johnson, N. Yamashita and H. Tanaka 2014

[雑誌論文] Co-occurrence of Estrogenic and Antiestrogenic Activities in Wastewater: Quantitative Evaluation of Balance by in Vitro ERα Reporter Gene Assay and Chemical Analysis

"Masaru Ihara, Mariko O. Ihara, Vimal Kumar, Masanori Narumiya, Seiya Hanamoto,Norihide Nakada, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, and Hiroaki Tanaka 2014

[学会発表] "Change of estrogenic activity of wastewater; comparison among in vitro ERα reporter gene assay,

"Masaru Ihara, Tomokazu Kitamura, Vimal Kumar, ChangBeom Park, Mariko O. Ihara, SunJun Lee, Kentarou Kobayashi, Hiroo Takabatake, Hiroaki Tanaka, Yuji Tanaka, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Seiichiro Okamoto, Yutaka Suzuki, and Hiroaki Tanaka 2014

[学会発表] "Detection of physiological activities of G protein-coupled receptor-acting pharmaceuticals

"Masaru Ihara, Asuka Inoue, Seiya Hanamoto, Han Zhang, Jyunken Aoki, and Hiroaki Tanaka 2014

[学会発表] "Comparison of physiological activities of pharmaceuticals in UK and Japan wastewater by TGFα shedding assay

"Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA 2014

[学会発表] Detection and comparison of physiological activities of pharmaceuticals in wastewater in UK and Japan

Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA 2014

[学会発表] 下水中の医薬品類の生理活性の検出

井原賢、井上飛鳥、花本征也、青木淳賢、田中宏明 2014

[図書] 生物応答を用いた排水評価・管理手法の国内外最新動向

田中宏明, 井原賢 (分担執筆) 2014

[学会発表] 河川における医薬品類の底質への収着に関する検討

花本征也、中田典秀、山下尚之、田中宏明 0

[学会発表] The Fate of selected Pharmaceuticals in a section of the River Thames and in Sewage Treatment Plants

S. Hanamoto, N. Nakada, M.D. Jürgens, A. C. Johnson, N. Yamashita, H. Tanaka 0

[学会発表] Detection of Estrogenic and Anti-Estrogenic Activities in Wastewater by in vitro ERalpha Reporter Gene Assay

Masaru Ihara, Mariko O. Ihara, Vimal Kumar, Masanori Narumiya, Seiya Hanamoto, Norihide Nakada, Naoyuki Yamashita, Shinichi Miyagawa, Taisen Iguchi, Hiroaki Tanaka 0

[学会発表] Comparison of physiological activities of pharmaceuticals in secondary effluent in UK and Japan

Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Hiroaki TANAKA 0