トップ研究者を探す遺伝子改変マウスと未固定遺体を用いた動脈硬化の新規の病態解明と治療法の開発

遺伝子改変マウスと未固定遺体を用いた動脈硬化の新規の病態解明と治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23K24330
研究種目 基盤研究(B)
研究分野
研究機関 徳島大学
代表研究者 佐田 政隆
研究分担者 福田 大受
研究分担者 添木 武
研究分担者 川端 豊
研究分担者 伊藤 孝司
研究期間 開始年月日 2022/4/1
研究期間 終了年度 2024
研究ステータス 交付 (2024/4/1)
配分額(合計) 17,680,000 (直接経費 :13,600,000、間接経費 :4,080,000)
配分額(履歴) 2024年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2023年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2022年度:9,360,000 (直接経費 :7,200,000、間接経費 :2,160,000)
キーワード 慢性炎症
生活習慣病
自然免疫
動脈硬化
インスリン抵抗性
脂質異常症

研究成果

[雑誌論文] Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment

Yamaji Takayuki、Sata Masataka、Ishibashi Yutaka、Node Koichi、Maemura Koji、Ohya Yusuke、Furukawa Taiji、Ito Hiroshi、Yamashina Akira、Koba Shinji、Higashi Yukihito 2024

[雑誌論文] LCZ696, an Angiotensin Receptor-Neprilysin Inhibitor, Ameliorates Endothelial Dysfunction in Diabetic C57BL/6 Mice

Munkhjargal Uugantsetseg、Fukuda Daiju、Maeda Juri、Hara Tomoya、Okamoto Shintaro、Bavuu Oyunbileg、Yamamoto Takayuki、Sata Masataka 2024

[雑誌論文] Lupus anticoagulant hypoprothrombinemia syndrome with multiple and high-titer antiphospholipid antibodies strongly interfered with coagulation assays

Sugasaki Motoki、Nakamura Shingen、Teramoto Keisuke、Urushihara Minami、Inoue Yusuke、Nakao Takayuki、Nishioka Yasuhiko、Sata Masataka 2024

[雑誌論文] Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers

Kawabata Yutaka、Wakatsuki Tetsuzo、Yamaguchi Koji、Fukuda Daiju、Ito Hiroyuki、Matsuura Tomomi、Kusunose Kenya、Ise Takayuki、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Tsuruo Yoshihiro、Sata Masataka 2023

[雑誌論文] A Selective Mineralocorticoid Receptor Blocker, Esaxerenone, Attenuates Vascular Dysfunction in Diabetic C57BL/6 Mice

Munkhjargal Uugantsetseg、Fukuda Daiju、Ganbaatar Byambasuren、Suto Kumiko、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2023

[雑誌論文] Emerging roles of protease-activated receptors in cardiometabolic disorders

Hara Tomoya、Sata Masataka、Fukuda Daiju 2023

[学会発表] Long-Term Outcome of Stentless Coronary Intervention With Drug-Coated Balloon in Patients With High Bleeding Risk.

Nagano K, Takahashi T, Wakatsuki T, Zheng R, Saijo Y, Kadota M, Kawabata Y, Matsuura T, Ise T, Yamaguchi K, Yagi S, Yamada H, Soeki T, Sata M 2023

[学会発表] Two-year outcomes of drug-coated balloon only strategy for de novo lesions in large coronary vessels,

Bando R, Wakatsuki T, Yamaguchi K, Kawabata Y, Takahashi T, Saijo Y, Kadota M, Matsuura T, Ise T, Kusunose K, Yagi S, Yamada H, Soeki T, Akaike M, Sata M 2023

[雑誌論文] Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers

Kawabata Yutaka、Wakatsuki Tetsuzo、Yamaguchi Koji、Fukuda Daiju、Ito Hiroyuki、Matsuura Tomomi、Kusunose Kenya、Ise Takayuki、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Tsuruo Yoshihiro、Sata Masataka 2023

[雑誌論文] Lipoprotein (a) is a risk factor of aortic valve calcification in patients with a risk of atherosclerosis

Tserensonom Munkhtsetseg、Yagi Shusuke、Ise Takayuki、Kawabata Yutaka、Kadota Muneyuki、Hara Tomoya、Kusunos Kenya、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2023

[雑誌論文] Emerging roles of protease-activated receptors in cardiometabolic disorders

Hara Tomoya、Sata Masataka、Fukuda Daiju 2023

[雑誌論文] Benefits of guideline-directed medical therapy to loop diuretics in management of heart failure

Kusunose Kenya、Okushi Yuichiro、Okayama Yoshihiro、Zheng Robert、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2023

[雑誌論文] Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)

Tanaka Atsushi、Sata Masataka、Tobiume Takeshi、Wakatsuki Tetsuzo、Yamada Hirotsugu、Yamaguchi Koji、Hotta Yuki、Iwasaki Mariko、Kazama Junichiro、Saito Yu、Sato Masahiro、Takiguchi Yoshinori、Tanabe Hayato、Watanabe Kiriko、Yamaguchi Mizuki、Tomita Sachiko、Kagiyama Mikiko、Onodera Keiko、the DIANA study investigators 2023

[雑誌論文] Endomyocardial biopsy-proven fulminant lymphocytic myocarditis presenting with mid-apical ballooning

Miyamoto Ryota、Ise Takayuki、Yoshida Tomoya、Sata Masataka 2023

[雑誌論文] Intimal Sarcoma of the Pulmonary Artery as an Embolic Cause of Sudden Death

Yagi Shusuke、Hara Tomoya、Yamada Hirotsugu、Kusunose Kenya、Ise Takayuki、Sata Masataka 2023

[雑誌論文] Message From the Editor-in-Chief ― <i>Circulation Reports</i>: 4 Years of Progress After Launch ―

Sata Masataka 2023

[雑誌論文] The Clinical Utility of Noninvasive Forrester Classification in Acute Heart Failure from PREDICT Study

Takahashi Tomonori、Iwano Hiroyuki、Shibayama Kentaro、Kitai Takeshi、Tanaka Hidekazu、Yamada Hirotsugu、Sata Masataka、Kusunose Kenya 2023

[学会発表] A selective mineralocorticoid receptor blocker, esaxerenone, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient mice.

Uugantsetseg Munkhjargal1, Fukuda D, Sata M 2023

[学会発表] The DEAD-Box RNA Helicase Ddx41 Contributes to Adverse Cardiac Remodeling During Pressure Overload Through Modulation of RNA Metabolism

Liu W, Higashikuni Y, Obana T, Tanaka Y, Hirata Y, Sata M 2023

[雑誌論文] Effectiveness of surveillance by echocardiography for cancer therapeutics-related cardiac dysfunction of patients with breast cancer

Okushi Yuichiro、Saijo Yoshihito、Yamada Hirotsugu、Toba Hiroaki、Zheng Robert、Seno Hiromitsu、Takahashi Tomonori、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka、Kusunose Kenya 2023

[学会発表] Macrophage-Specific DNaseII Deficiency Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.

Suto K, Hara T, Nishimoto S, Kaneyama S, Sata M, Fukuda D 2023

[雑誌論文] Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice

Hara Tomoya、Fukuda Daiju、Ganbaatar Byambasuren、Pham Phuong Tran、Aini Kunduziayi、Rahadian Arief、Suto Kumiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Sata Masataka 2023

[雑誌論文] Drug-coated balloon angioplasty for severe pulmonary vein stenosis resulting from cryoballoon ablation for atrial fibrillation

Yamaguchi Koji、Wakatsuki Tetsuzo、Matsuura Tomomi、Matsumoto Kazuhisa、Kawabata Yutaka、Kadota Muneyuki、Kusunose Kenya、Ise Takayuki、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Sata Masataka 2022

[雑誌論文] Isoproterenol loading transesophageal echocardiography in atrial fibrillation

Takahashi Tomonori、Kusunose Kenya、Hayashi Shuji、Zheng Robert、Yamaguchi Natsumi、Morita Sae、Hirata Yukina、Nishio Susumu、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2022

[雑誌論文] Pulmonary Tumor Thrombotic Microangiopathy Due to Gastric Cancer Diagnosed Antemortem by a Cytological Examination of Aspirated Pulmonary Artery Blood

Mitsui Yasuhiro、Yagi Mai、Muraki Sho、Matsuura Tomomi、Bando Yoshimi、Fujimoto Shota、Kitamura Shinji、Okamoto Koichi、Muguruma Naoki、Sata Masataka、Takayama Tetsuji 2022

[雑誌論文] Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease

Takahashi Tomonori、Kusunose Kenya、Zheng Robert、Yamaguchi Natsumi、Hirata Yukina、Nishio Susumu、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2022

[雑誌論文] Clinical course and decision‐making in heart failure by preload stress echocardiography: a preliminary study

Kusunose Kenya、Yamada Hirotsugu、Saijo Yoshihito、Nishio Susumu、Hirata Yukina、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2022

[学会発表] Lipoprotein (a) is a Residual Risk Factor of Aortic Valve Calcification in Patients With High Risk of Atherosclerosis

Yagi S, Munkhtsetseg Tserensonom, Sata M 2022

[雑誌論文] Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet

Bavuu Oyunbileg、Fukuda Daiju、Ganbaatar Byambasuren、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2022

[雑誌論文] Effect of canagliflozin on white blood cell counts in patients with type 2 diabetes and heart failure: A subanalysis of the randomized CANDLE trial

Tanaka Atsushi、Imai Takumi、Shimabukuro Michio、Nakamura Ikuko、Matsunaga Kazuo、Ozaki Yukio、Minamino Tohru、Sata Masataka、Node Koichi、CANDLE trial investigators 2022

[雑誌論文] Comparing the Effects of Canagliflozin vs. Glimepiride by Body Mass Index in Patients with Type 2 Diabetes and Chronic Heart Failure: A Subanalysis of the CANDLE Trial

Sezai Akira、Tanaka Atsushi、Imai Takumi、Kida Keisuke、Sekino Hisakuni、Murohara Toyoaki、Sata Masataka、Suzuki Norio、Node Koichi 2022

[雑誌論文] New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy

Matsuda Noritake、Otsuka Hideki、Otani Tamaki、Azane Shota、Kunikane Yamato、Otomi Yoichi、Ueki Yuya、Kubota Masahiro、Amano Masafumi、Yagi Shusuke、Sata Masataka、Harada Masafumi 2022

[雑誌論文] JCS/JSCVS 2018 Guideline on Revascularization of Stable Coronary Artery Disease

Nakamura Masato、Sata Masataka、Takanashi Shuichiro 2022