トップ研究者を探すサルコペニック肥満の病態解明に関する研究

サルコペニック肥満の病態解明に関する研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23390188
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
内科学一般(含心身医学)
研究機関 愛媛大学
代表研究者 小原 克彦
研究分担者 茂木 正樹
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 19,110,000 (直接経費 :14,700,000、間接経費 :4,410,000)
配分額(履歴) 2013年度:5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000)
2012年度:4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
2011年度:8,580,000 (直接経費 :6,600,000、間接経費 :1,980,000)
キーワード 内臓肥満
サルコペニア
動脈スティフネス
機能障害
代謝異常
アディポカイン
肥満
動脈硬化
老化因子
モデル動物
プレ・フレイルティ
認知機能
サルコペニック肥満
重心動揺
起立性低血圧
縦断研究
起立性血圧変動

研究成果

[雑誌論文] Postprandial hypotension as a risk marker for asymptomatic lacunar infarction.

Tabara Y, Okada Y, Uetani E, Nagai T, Igase M, Kido T, Ochi N, Ohara M, Takita R, Kohara K, Miki T. 2014

[雑誌論文] Sarcopenic obesity and arterial stiffness, pressure wave reflection and central pulse pressure : The J-SHIPP study

Ohara M, Kohara K, Tabara Y, Ochi M, Nagai T, Igase M, Miki T 2014

[雑誌論文] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade

Ohshima K, Mogi M(31人中②), et al 2014

[雑誌論文] Sarcopenic obesity in aging population : current status and future directions for research

Kohara K 2014

[雑誌論文] Change in arterial stiffness associated with monthly bisphosphonate treatment in women with postmenopausal osteoporosis.

Igase M, Kohara K, Tabara Y, Ohara M, Takita R, Ochi M, Okada Y, Miki T. 2014

[雑誌論文] Interaction between serum uric acid and triglycerides in relation to prehypertension in community-dwelling Japanese adults.

Kawamoto R, Tabara Y, Kohara K, Kusunoki T, Abe M, Miki T. 2014

[雑誌論文] Clinical Characteristics of High Plasma Adiponectin and High Plasma Leptin as Risk Factors for Arterial Stiffness and Related End-Organ Damage

Kohara K, (10人中①), et al 2014

[学会発表] 高齢者高血圧の特徴と治療 JSH2014を踏まえて

小原克彦 2014

[学会発表] 高血圧と認知症

小原克彦 2014

[雑誌論文] CDH13 genotype-dependent association of high-molecular weight adiponectin with all-cause mortality: the J-SHIPP study.

Uetani E, Tabara Y, Kawamoto R, Onuma H, Kohara K, Osawa H, Miki T. 2014

[学会発表] Fit elderlyとFrail elderly:FitとFrailの判定と降圧目標

小原克彦 2014

[雑誌論文] Direct Stimulation of Angiotensin II Type 2 Receptor Initiated After Stroke Ameliorates Ischemic Brain Damage

Min LJ, Mogi M (12人中②), et al 2014

[雑誌論文] Sarcopenic obesity in aging population: current status and future directions for research.

Kohara K. 2014

[雑誌論文] Association of longer QT interval with arterial waveform and lower pulse pressure amplification: the Nagahama Study.

Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S, Sekine A, Miki T, Nakayama T, Matsuda F; Nagahama Study Group. 2013

[雑誌論文] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP and Toon Health Study.

Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T. 2013

[学会発表] サルコペニック肥満の臨床

小原克彦 2013

[図書] 今日の循環器疾患治療指針 第3版

小原克彦 2013

[学会発表] Arterial aging and sarcopenia

Katsuhiko Kohara 2013

[図書] 高齢者の高血圧今日の循環器疾患治療指針第3版

小原克彦. 井上博, 許俊鋭, 檜垣実男, 代田浩之, 筒井裕之編 2013

[学会発表] JSH2014改訂に向けてのトピックス:高齢者高血圧の治療を中心に

小原克彦 2013

[学会発表] Clinical implication of pulse wave analysis; from radial to central BP

Kohara K 2013

[雑誌論文] Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women.

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M, Katoh T, Ohtsuka N. 2013

[学会発表] Clinical implication of pulse wave analysis; from radial to central BP

Katsuhiko Kohara 2013

[学会発表] Arterial aging and sarcopenia

Kohara K 2013

[図書] 高血圧診療のすべて

小原克彦 2013

[雑誌論文] Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations.

Gao H, Kim YM, Chen P, Igase M, Kawamoto R, Kim MK, Kohara K, Lee J, Miki T, Ong RT, Onuma H, Osawa H, Sim X, Teo YY, Tabara Y, Tai ES, van Dam RM. 2013

[雑誌論文] Visit-to-visit variability in systolic blood pressure is a novel risk factor for the growth of intracranial aneurysms.

Igase M, Igase K, Kohara K, Yamashita S, Fujisawa M, Katagi R, Miki T. 2013

[雑誌論文] Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population.

Kawamoto R, Tabara Y, Kohara K, Kusunoki T, Abe M, Miki T. 2013

[学会発表] Arterial aging and sarcopenia. Presidential symposium : arterial component of age-related diseases

Kohara K 2013

[雑誌論文] A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes.

Kawamoto R, Tabara Y, Kusunoki T, Abe M, Kohara K, Miki T. 2013

[雑誌論文] An association between body mass index and high-sensitivity C-reactive protein concentrations is influenced by age in community-dwelling persons.

Kawamoto R, Kusunoki T, Abe M, Kohara K, Miki T. 2013

[図書] 老年病・認知症 長寿の秘訣 改訂版

小原克彦 2013

[雑誌論文] Hematological parameters are associated with metabolic syndrome in Japanese community-dwelling persons.

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Abe M, Katoh T. 2013

[学会発表] 中心血圧による高血圧診断の有用性

小原克彦 2013

[雑誌論文] rterial stiffness in sarcopenic visceral obesity in the elderly : J-SHIPP study

Kohara K, 他 2012

[図書] Advances in Medicine and Biology

Kohara K, 他 2012

[雑誌論文] Central blood pressure and end-organ damage

Kohara K 2012

[雑誌論文] Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects : J-SHIPP study

Kido M, Kohara K, 他 2012

[雑誌論文] Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Kawamoto R, Kohara K (6人中②), et al 2012

[雑誌論文] Potential utility of soluble p3-Alcadeina plasma levels as a biomarker for sporadic Alzheimer's disease

Kamogawa K, Kohara K, 他 2012

[学会発表] 起立性低血圧・食後性低血圧 シンポジウム

小原克彦 2012

[図書] ポリピル高血圧療法における併用療法檜垣実男編

小原克彦 2012

[学会発表] Thigh Muscle Mass Decline Was Associated Brain Small Vessel Diseases in Men; Possible Link between Sarcopenia and Dementia.

Kohara K 2012

[学会発表] サルコペニアの臨床 エイジングサイエンス・シンポジウム

小原克彦 2012

[学会発表] 高齢者の最終降圧目標 ディベート

小原克彦 2012

[学会発表] Epidemiological Studies Suggest the Link between Sleep Disorders and Nonspecific Headache Including Chronic Headache.

Kohara K 2012

[図書] 頸動脈エコー脂質異常症・肥満 動脈硬化

小原克彦, 荻原俊男 2011

[学会発表] Mechanical stresses in the common carotid artery in patients with small vessel disease

Okada Y、Kohara K, 他 2011

[学会発表] Increased levels of soluble p3-Alcadeinain plasma of patients with Alzheimer's disease

KamogawaK、Kohara K, 他 2011

[学会発表] Arterial Stiffness in Sarcopenic Obesity, the Common Form of Obesity in the Elderly : J-SHIPP Study

Kohara K, 他 2011

[雑誌論文] Hemoglobin is associated with serum high molecular weight adiponectin in Japanese community-dwelling persons

Kawamoto R, Kohara K, 他 2011

[学会発表] Relatively Lower Central Aortic Pressure in Subjects with Impaired Insulin Sensitivity and Eesistance : The Toon Health Study

Tabara Y, Kohara K, 他 2011

[学会発表] Postprandial Hypertension, an Overlooked Risk Factor for Arterial Stiffness

Uetani E, Kohara K, 他 2011

[雑誌論文] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance : the Toon Health Study

Tabara Y, Kohara K, 他 2011

[学会発表] Arterial Stiffness Associates with Cognitive Impairment and Brain Atrophy : J-SHIPP Study

KidoM, Kohara K, 他 2011

[学会発表] Atherosclerotic indices for the presence of cognitive impairment in a general population : J-SHIPP Study

Kohara K, 他 2011

[学会発表] 認知機能と動脈硬化指数 シンポジウム

小原克彦