細胞老化現象に着目した高齢者の精神神経疾患研究

トップ›研究者を探す›細胞老化現象に着目した高齢者の精神神経疾患研究

代表研究者	伊賀淳一
研究課題番号	KAKENHI-PROJECT-22K07597
研究種目	基盤研究(C)
研究分野
研究機関	愛媛大学
研究期間開始年月日	2022/4/1
研究期間終了年度	2024
研究ステータス	完了 (2024/4/1)
配分額（合計）	4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
配分額（履歴）	2024年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2023年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000) 2022年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード	細胞老化認知症うつ病アパシーストレスオートファジーミトコンドリア炎症高齢者軽度認知障害血液アルツハイマー型認知症精神神経疾患モデル動物

研究成果

[雑誌論文] Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Shibata Shutaro、Noguchi-Shinohara Moeko、Shima Ayano、Ozaki Taro、Usui Yuta、Taki Yasuyuki、Uchida Kazuhiro、Honda Takanori、Hata Jun、Ohara Tomoyuki、Mikami Tatsuya、Maeda Tetsuya、Mimura Masaru、Nakashima Kenji、Iga Jun-ichi et al. 2025

[雑誌論文] Effects of Psychotropic Medications Taken by Pregnant Women on Newborn Medical Condition and Lactation Method

Yoshino Yuta、Yagi Toru、Tsubouchi Koichi、Takaishi Yusuke、Ozaki Yuki、Iga Jun‐ichi、Matsubara Keiichi、Matsubara Yuko、Uchikura Yuka、Sugiyama Takashi、Ueno Shu‐ichi 2025

[学会発表] アルツハイマー型認知症の疫学、病態、症状

伊賀淳一 2025

[雑誌論文] Associations between clozapine availability, the diagnosis of treatment-resistant schizophrenia subgroups, antipsychotic monotherapy, and concomitant psychotropics among patients with schizophrenia: a real-world nationwide study

Ochi Shinichiro、Kodaka Fumitoshi、Hasegawa Naomi、Tsuboi Takashi、Ohi Kazutaka、Igarashi Shun、Fukumoto Kentaro、Iga Jun-ichi et al. 2025

[学会発表] 非定型の特徴は臨床に役立つのか？

伊賀淳一 2024

[学会発表] 特定用語

伊賀淳一 2024

[雑誌論文] Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Tachibana Ayumi、Iga Jun-ichi et al. 2024

[学会発表] アルツハイマー型認知症におけるドラッグリポジショニングの可能性

伊賀淳一 2024

[雑誌論文] Randomized open-label study of second-generation antipsychotics for the treatment of schizophrenia: 104-week final results of the JUMPs study assessing treatment discontinuation, remission, and social functioning

Ishigooka Jun、Nakagome Kazuyuki、Ohmori Tetsuro、Iwata Nakao、Inada Ken、Iga Jun-ichi、Kishi Taro、Fujita Kiyoshi、Kikuchi Yuka、Shichijo Toshiaki、Tabuse Hideaki、Koretsune Shotatsu、Terada Hiroshi、Terada Haruko、Kishimoto Toshifumi、Tsutsumi Yuichiro、Ohi Kazutaka 2024

[雑誌論文] The association between benzodiazepine prescriptions and the risk of laxative use in schizophrenia treatment

Ochi Shinichiro、Tsuboi Takashi、Hasegawa Naomi、Hori Hikaru、Ichihashi Kayo、Imamura Yayoi、Okada Tsuyoshi、Kodaka Fumitoshi、Saito Yoshitaka、Iga Jun‐ichi、Onitsuka Toshiaki、Atake Kiyokazu、Ueno Shu‐ichi、Hashimoto Ryota、Yasui‐Furukori Norio 2024

[雑誌論文] Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer's disease and mitochondrial function in mild cognitive impairment

Iga Jun-ichi、Yoshino Yuta、Ozaki Tomoki、Tachibana Ayumi、Kumon Hiroshi、Funahashi Yu、Mori Hiroaki、Ueno Mariko、Ozaki Yuki、Yamazaki Kiyohiro、Ochi Shinichiro、Yamashita Masakatsu、Ueno Shu-ichi 2024

[学会発表] Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer’s disease and mitochondrial function in mild cognitive impairment.

Jun-ichi Iga, Yuta Yoshino, Tomoki Ozaki, Ayumi Tachibana, Hiroshi Kumon, Yu Funahashi, Hiroaki Mori, Mariko Ueno, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Masakatsu Yamashita, Shu-ichi Ueno 2024

[雑誌論文] Sleep Awareness of Japanese Outpatients: A Survey at a Psychiatry Department of a University Hospital

Soga Junya、Kawabe Kentaro、Horiuchi Fumie、Yoshino Yuta、Ozaki Yuki、Nakachi Kiwamu、Hosokawa Rie、Inoue Saori、Matsumoto Yu、Okazawa Maya、Iga Jun-ichi、Ueno Shu-Ichi 2024

[雑誌論文] A web‐based survey on the occurrence of emotional blunting in patients with major depressive disorder in Japan: Patient perceptions and attitudes

Kikuchi Toshiaki、Iga Jun‐ichi、Oosawa Masato、Hoshino Tatsuya、Moriguchi Yoshiya、Izutsu Miwa 2024

[学会発表] 非定型うつ病の疾患論的位置づけ（特に双極症との相違や共通点など）

伊賀淳一 2024

[学会発表] クロザピンの効果と副作用

伊賀淳一 2024

[学会発表] Microglial changes of the delayed carbon monooxide encephalopahty rat model.

Ochi S, Nishihara T, Boku S, Iga J, Ueno SI 2023

[学会発表] 高齢者のうつ病　治療ガイドラインを臨床に活かす

伊賀淳一 2023

[雑誌論文] Effects of gestational haloperidol exposure on mRNA expressions related to glutamate and GABA receptors in offspring

Kumon Hiroshi、Yoshino Yuta、Funahashi Yu、Ochi Shinichiro、Iga Jun-ichi、Ueno Shu-ichi 2023

[学会発表] Aberrant Expression of GABA-Related Genes in the Hippocampus of 3xTg-AD Model Mice from the Early to End stages of Alzheimer's Disease.

Mori H, Yoshino Y, Iga J, Ueno SI 2023

[学会発表] COVID-19がもたらしたうつ病治療への影響

伊賀淳一 2023

[雑誌論文] Analysis of factors related to cognitive impairment in a community‐based, complete enumeration survey in Japan: the Nakayama study

Yoshida Taku、Mori Takaaki、Shimizu Hideaki、Tachibana Ayumi、Yoshino Yuta、Ochi Shinichiro、Yamazaki Kiyohiro、Ozaki Yuki、Kawabe Kentaro、Horiuchi Fumie、Komori Kenjiro、Iga Jun‐ichi、Ueno Shu‐ichi 2023

[学会発表] 中山町コホートを用いた研究

伊賀淳一 2023

[雑誌論文] Gestational exposure to haloperidol changes Cdkn1a and Apaf1 mRNA expressions in mouse hippocampus

Kumon Hiroshi、Yoshino Yuta、Ozaki Tomoki、Funahashi Yu、Mori Hiroaki、Ueno Mariko、Ozaki Yuki、Yamazaki Kiyohiro、Ochi Shinichiro、Iga Jun-ichi、Ueno Shu-ichi 2023

[雑誌論文] Impact of clozapine on the expression of miR-675-3p in plasma exosomes derived from patients with schizophrenia

Funahashi Yu、Yoshino Yuta、Iga Jun-ichi、Ueno Shu-ichi 2022

[雑誌論文] Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan

Kumon Hiroshi、Miyake Yoshihiro、Yoshino Yuta、Iga Jun-ichi、Tanaka Keiko、Senba Hidenori、Kimura Eizen、Higaki Takashi、Matsuura Bunzo、Kawamoto Ryuichi、Ueno Shu-ichi 2022

[学会発表] 中山町コホートを用いた生物学的研究

伊賀淳一 2022

[雑誌論文] Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment

Kawakami Ito、Iga Jun‐ichi、Takahashi Sho、Lin Yi‐Ting、Fujishiro Hiroshige 2022

[学会発表] Emotional Bluntingは本当に存在するのか？

伊賀淳一 2022

[雑誌論文] Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer’s disease (from the Nakayama Study)

Ozaki Tomoki、Yoshino Yuta、Tachibana Ayumi、Shimizu Hideaki、Mori Takaaki、Nakayama Tomohiko、Mawatari Kazuaki、Numata Shusuke、Iga Jun-ichi、Takahashi Akira、Ohmori Tetsuro、Ueno Shu-ichi 2022

[雑誌論文] Association Study and Meta-Analysis of Polymorphisms and Blood mRNA Expression of the ALDH2 Gene in Patients with Alzheimer’s Disease

Ueno Mariko、Yoshino Yuta、Mori Hiroaki、Funahashi Yu、Kumon Hiroshi、Ochi Shinichiro、Ozaki Tomoki、Tachibana Ayumi、Yoshida Taku、Shimizu Hideaki、Mori Takaaki、Iga Jun-ichi、Ueno Shu-ichi 2022

[学会発表] 双極性障害におけるDSMの重要性と限界

伊賀淳一 2022

[雑誌論文] Secular trends in the prevalence of dementia based on a community‐based complete enumeration in Japan: the Nakayama Study

Shimizu Hideaki、Mori Takaaki、Yoshida Taku、Tachibana Ayumi、Ozaki Tomoki、Yoshino Yuta、Ochi Shinichiro、Sonobe Naomi、Matsumoto Teruhisa、Komori Kenjiro、Iga Jun‐ichi、Ninomiya Toshiharu、Ueno Shu‐ichi、Ikeda Manabu 2022

[雑誌論文] Guidelines for diagnosis and treatment of depression in older adults: A report from the Japanese Society of mood disorders

Baba Hajime、Kito Shinsuke、Nukariya Kazutaka、Takeshima Minoru、Fujise Noboru、Iga Junichi、Oshibuchi Hidehiro、Kawano Masahiko、Kimura Mahiko、Mizukami Katsuyoshi、Mimura Masaru、Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders 2022

[雑誌論文] Prevalence of Comorbid Dementia in Late-life Depression and Bipolar Disorder: A Retrospective Inpatient Study

Ochi Shinichiro、Mori Takaaki、Iga Jun-ichi、Ueno Shu-ichi 2022

[雑誌論文] Blood <i>MAPT</i> expression and methylation status in Alzheimer's disease

Mori Hiroaki、Yoshino Yuta、Ueno Mariko、Funahashi Yu、Kumon Hiroshi、Ozaki Yuki、Yamazaki Kiyohiro、Ochi Shinichiro、Iga Jun‐ichi、Ueno Shu‐ichi 2022