トップ›研究者を探す›分子シャペロンによるミスフォールディングタンパク質の凝集ダイナミクス

分子シャペロンによるミスフォールディングタンパク質の凝集ダイナミクス

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22770117
研究種目 若手研究(B)
研究分野 生物系
生物学
生物科学
構造生物化学
研究機関 独立行政法人理化学研究所
代表研究者 座古 保
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額（履歴） 2011年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2010年度：2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
キーワード アミロイド
分子シャペロンタンパク質
ミスフォールディングタンパク質凝集
プレフォルディン
可溶性オリゴマー
細胞毒性
タンパク質ミスフォールディング病
アルツハイマー病
アミロイドβ
タンパク質凝集

研究成果

[雑誌論文] Cell interaction study of amyloid using luminescent conjugated polythiophene : Implication that amyloid cytotoxicity is correlated with prolonged cellular binding

Tamotsu Zako 2012

[学会発表] Function and application of protein molecules and bio-nanoparticles

Tamotsu Zako and Mizuo Maeda 2011

[学会発表] Development of new photon counting histogram method towards precise analysis of oligomerization

Naofumi Terada, Tamotsu Zako, Masafumi Sakono and Mizuo Maeda 2011

[雑誌論文] Application of two morphologically different fibrillar and filamentous insulin amyloids as a biomaterial for cell culture surfaces

Sakono M, Akiyama S, Zako T., Sakaki S, Waku T, Tanaka N, Maeda M 2011

[学会発表] Noodle'-like filaments of bovine insulin and ss2 microglobulin were non-cytotoxic due to abbreviated cell binding

Tamotsu Zako 2011

[学会発表] Noodle'-like filaments of bovine insulin andβ2 microglobulin were non-cytotoxic due to abbreviated cell binding

Tamotsu Zako, Masafumi Sakono, Takahiro Kobayashi, K. Peter R. Nilsson, Per Hammarstrom, Mikael Lindgren and Mizuo Maeda 2011

[雑誌論文] Immobilized Insulin Amyloid Enhances Cell Adhesion and Proliferation due to Interaction with Fibronectin

Sakono M, Akiyama S, Zako T., Sakaki S, Waku T, Tanaka N, Maeda M 2011

[学会発表] 近赤外光を用いたバイオイメージングのためのナノ粒子開発とその応用

座古保 2011

[学会発表] Formation of non-toxic Abeta amyloids by small heat shock protein(sHsp) under stress condition

Tamotsu Zako, Masafumi Sakono, Arata Utsum, Chika Sugino, Masafumi Yohda, Mizuo Maeda 2010

[学会発表] Formation of non-toxic Abeta fibrils by small heat shock protein (sHsp) under stress condition

Tamotsu Zako 2010

[雑誌論文] Analysis of interaction mode between hyperthermophilic archaeal group II chaperonin and prefoldin using a platform of chaperonin oligomers of various subunit arrangements

Sahlan M., Kanzaki T., Zako T., Maeda M. and Yohda M. 2010

[学会発表] Amyloid Beta Oligomer Studied By photon counting histogram

Naofumi Terada, Tamotsu Zako, Masafumi Sakono and Mizuo Maeda 2010

[学会発表] Supramolecular photochirogenesis with biomolecular hosts

Y. Inoue, M. Nishijima, C. Yang, T. Mori, T. Wada, K. Bando, T. Zako, M. Sakon, M. Maeda, T. Pace, C. Bohne 2010

[雑誌論文] Size-selective recognition of gold nanoparticles by a molecular chaperone

Sakono M, Zako T., Drakulic S, Valpuesta J. M, Yohda M and Maeda M 2010

[雑誌論文] Hyperthermophilic archaeal prefoldin shows refolding activity at low temperature

Tamotsu Zako 2010

[雑誌論文] Amyloid oligomers : Formation and toxicity of Abeta oligomers

Sakono M. and Zako T. 2010

[学会発表] ポリグルタミンタンパク質凝集における分子シャペロンプレフォルディンの役割

伊藤禎宣、座古保、Karin Sorgjerd、寺田尚史、田代絵梨佳、北村朗、久保田広志、武藤秀樹、金城政孝、有賀寛芳、前田瑞夫 2010

[学会発表] Formation of non-toxic Abeta amyloids by small heat shock protein (sHsp) under stress condition

Tamotsu Zako 2010

[雑誌論文] Thermodynamic Characterization of the Interaction between Prefoldin and Group II Chaperonin

Sahlan M., Zako T., Tai Phan The, Ohtaki A., Noguchi K., Maeda M., Miyatake H., Dohmane N. and Yohda M. 2010

[学会発表] Molecular chaperone prefoldin blocks the formation of mutant Huntingtin oligomer and inclusion body, resulting in reduction of its cytotoxity

Erika Tashiro, Hideki Muto, Tamotsu Zako, Makoto Miyazawa, Hirotake Kitaura, Akira Kitamura, Hiroshi Kubota, Mizuo Maeda, Masataka Kinjo, Hiroyoshi Ariga 2010

[学会発表] 分子シャペロンPrefoldinは変異ハンチンチンのオリゴマーおよび凝集体形成を阻害して細胞死を減少させる

田代絵梨佳,武藤秀樹,座古保,宮澤誠,北浦廣剛,北村朗,久保田広志,前田瑞夫,金城政孝,有賀寛芳 2010

[学会発表] The Molecular Chaperone Prefoldin can Capture Aggregation Prone States of A-Beta and Might Play a Role in the Progress of Alzheimer's Disease

Karin Sorgjerd, Tamotsu Zako, Masafumi Sakono, Peter Stirling, Michel Leroux, Mizuo Maeda 2010

[学会発表] 分子シャペロンをめぐる分子間相互作用の解析

養王田正文、阿部哲也、Sahlan Muhamad, Phan The tai,神埼太郎、岡俊彦、座古保、前田瑞夫 2010

[学会発表] The molecular chaperone prefoldin can capture aggregation prone states of A-beta and might play a role in the progress of Alzheimers disease

Karin Sorgjerd, Tamotsu Zako, Masafumi Sakono, Peter Stirling, Michel Leroux, Mizuo Maeda 2010

[雑誌論文] Bio-Supramolecular Photochirogenesis with Molecular Chaperone : Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Prefoldin

Bando K., Zako T., Sakono M., Maeda M., Wada T., Nishijima M., Fukuhara G., Yang C., Mori T., Pace TCS., Bohne C. and Inoue Y. 2010

[学会発表] Formation of non-toxic Abeta fibrils by small heat shock protein(sHsp) under stress condition

Tamotsu Zako, Masafumi Sakono, Arata Utsum, Chika Sugino, Masafumi Yohda, Mizuo Maeda 2010

[学会発表] Toxic amyloid oligomer detection system using molecular chaperone

Masafumi Sakono, Tamotsu Zako, Masafumi Yohda and Mizuo Maeda 2010

[雑誌論文] Amyloid oligomers

Tamotsu Zako 2010

[雑誌論文] Hyperthermophilic archaeal prefoldin shows refolding activity at low temperature

Zako T., Banba S., Sahlan M., Sakono M., Terada N., Yohda M. and Maeda M. 2010