トップ›研究者を探す›血液脳関門ヘミチャネルの病態生理学的役割と分子標的診断・治療

血液脳関門ヘミチャネルの病態生理学的役割と分子標的診断・治療

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22689005
研究種目 若手研究(A)
研究分野 生物系
医歯薬学
薬学
医療系薬学
研究機関 東北大学
富山大学
代表研究者 立川 正憲
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額（合計） 25,350,000 (直接経費 :19,500,000、間接経費 :5,850,000)
配分額（履歴） 2013年度：4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2012年度：5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000)
2011年度：8,190,000 (直接経費 :6,300,000、間接経費 :1,890,000)
2010年度：7,280,000 (直接経費 :5,600,000、間接経費 :1,680,000)
キーワード ヘミチャネル
脳毛細血管内皮細胞
パネキシン
コネキシン
輸送
血液脳関門
病態
阻害
トランスポーター

研究成果

[図書] Recent progress in the blood-brain barrier and the blood-CSF barrier transport research : Pharmaceutical relevance of drug delivery to the brain. Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)

Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T 2014

[学会発表] Pharmacological impact of the brain barrier prostaglandin transport

Tachikawa M 2014

[雑誌論文] Quantitative targeted proteomics for understanding the blood-brain barrier : towards pharmacoproteomics

Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T 2014

[学会発表] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性

立川正憲, 金子洋介, 赤荻諒, 内田康雄, 大槻純男, 寺崎哲也 2014

[図書] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)

Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T 2014

[図書] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches

Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T 2014

[図書] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches

Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T 2014

[学会発表] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport

Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T 2013

[学会発表] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能

立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也 2013

[学会発表] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport: An application of quantitative targeted proteomics

Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T. 2013

[雑誌論文] 血液脳関門トランスポートソームの定量的絶対発現プロファイル : 動物種間, 系統間, 野生型-遺伝子欠損マウス間の相違性と類似性

内田康雄, 立川正憲, 星裕太朗, 寺崎哲也 2013

[雑誌論文] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice

Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T 2013

[学会発表] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築

立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也 2013

[雑誌論文] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset.

Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T 2013

[雑誌論文] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model

Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T 2013

[雑誌論文] 動的インターフェースとしての脳関門輸送システムと脳関門生理学・創薬研究

立川正憲, 内田康雄, 寺崎哲也 2013

[学会発表] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport.

Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T. 2013

[雑誌論文] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset

Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T 2013

[雑誌論文] 血液脳関門トランスポートソームの定量的絶対発現プロファイル：動物種間，系統間，野生型-遺伝子欠損マウス間の相違性と類似性

内田康雄、立川正憲、星裕太朗、寺崎哲也 2013

[雑誌論文] 標的絶対定量プロテオミクスが拓くヒト血液脳関門輸送機能研究

立川正憲, 内田康雄, 寺崎哲也 2013

[学会発表] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport : An application of quantitative targeted proteomics

Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T 2013

[学会発表] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier

Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T 2013

[学会発表] 血液脳関門輸送機能変動因子としてのヘミチャネル

立川正憲 2013

[学会発表] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research

Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T 2013

[学会発表] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents

立川正憲, 村上晃路, 赤沼伸乙, 細谷健一 2012

[雑誌論文] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters

Tachikawa M, Tsuji K, Yokoyama R, Higuchi T, Ozeki G, Yashiki A, Akanuma S, Hayashi K, Nishiura A, Hosoya K 2012

[雑誌論文] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E_2 produced in the brain

Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K 2012

[学会発表] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells

金子洋介、立川正憲, 他 2012

[雑誌論文] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain.

Tachikawa M 2012

[学会発表] Profile of hemichannls mRNA expresson at the blood-brain and inner blood-retinal barriers in mice

Akanuma S, Murakami K, Tachikawa M, Kubo Y, Hosoya K 2012

[学会発表] Pathophysiological impact of hemichannels on the blood-brain barrier transport.

Tachikawa M 2012

[学会発表] ヘミチャネルファミリーを標的とした定量プロテオミクス

立川正憲, 金子洋介, 内田康雄, 寺崎哲也 2012

[学会発表] 脳及び網膜毛細血管皮細胞におけるヘミチャネル分子のmRNA発現解析

村上晃路、立川正憲, 他 2012

[雑誌論文] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.

Tachikawa M 2012

[学会発表] 脳及び網膜毛細血管内皮細胞におけるヘミチャネル分子のmRNA 発現解析

村上晃路, 立川正憲, 赤沼伸乙, 久保義行, 細谷健一 2012

[学会発表] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells

金子洋介, 立川正憲, 寺崎哲也 2012

[学会発表] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier

Tachikawa M, Kaneko Y, Uchida Y, Ohtsuki S, Couraud PO, Terasaki T 2012

[学会発表] Proteomics-based technology as a new path to toxicological evaluation

Tachikawa M 2012

[学会発表] Pathophysiological impact of hemichannels on the blood-brain barrier transport

Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T 2012

[学会発表] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents

立川正憲、村上晃路, 他 2012

[雑誌論文] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model.

Ohtsuki S 2012

[雑誌論文] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier

Tachikawa M, Murakami K, Martin P, Hosoya K, Ganapathy V 2011

[雑誌論文] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins

Hosoya K, Tachikawa M 2011

[雑誌論文] The inner blood-retinal barrier mediates L-isomer-predominant transport of serine

Tachikawa M., Okamoto M., et al 2011

[雑誌論文] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier

Tachikawa M., Murakami K., et al 2011

[雑誌論文] 定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能

立川正憲, 内田康雄, 大槻純男, 寺崎哲也 2011

[学会発表] グアニジノ化合物のトランスポーターと脳関門輸送

立川正憲 2011

[学会発表] グアニジノ化合物のトランスポーターと脳関門輸送

立川正憲 2011

[雑誌論文] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.

Tachikawa M. 2011

[雑誌論文] Hypertonicity Enhances GABA Uptake by Cultured Rat Retinal Capillary Endothelial Cells

Yahara T, Tachikawa M, Akanuma S, Hosoya K 2011

[図書] Systemic route for retinal drug delivery : role of the blood-retinal barrier transporters. Drug Product Development for the Back of the Eye, Kompella U. B. and Edelhauser H. F. (Ed), American Association of Pharmaceutical Scientists

Tachikawa M, Ganapathy V, Hosoya K 2011

[雑誌論文] Strategies for therapy of retinal diseases using systemic drug delivery : relevance of transporters at the blood-retinal barrier

Hosoya K, Tomi M, Tachikawa M 2011

[雑誌論文] Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T 2011

[雑誌論文] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders

Tachikawa M, Hosoya K 2011

[雑誌論文] The Inner Blood-Retinal Barrier Mediates L-Isomer-Predominant Transport of Serine

Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K 2011

[図書] Systemic route for retinal drug delivery : role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye

Tachikawa M., Ganapathy V., Hosoya K. 2011

[学会発表] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割

立川正憲 2010

[学会発表] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割

立川正憲, 細谷健一 2010

[雑誌論文] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability

Hosoya K, Yamamoto A, Akanuma S, Tachikawa M 2010

[学会発表] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築

立川正憲

[学会発表] Proteomics-based technology as a new path to toxicological evaluation

Tachikawa M

[学会発表] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能

立川正憲、金子洋介、内田康雄、大槻純男、寺崎哲也

[学会発表] 血液脳関門輸送機能変動因子としてのヘミチャネル

立川正憲

[学会発表] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier.

Tachikawa M

[学会発表] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research

Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.

[学会発表] Pharmacological impact of the brain barrier prostaglandin transport

Tachikawa M.

[学会発表] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性

立川正憲、金子洋介、赤荻諒、内田康雄、大槻純男、寺崎哲也

[学会発表] ヘミチャネルファミリーを標的とした定量プロテオミクス

立川正憲

[学会発表] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier.

Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.