トップ›研究者を探す›膜型増殖因子のER/核膜オートトランスロケーション分子機構解明とがん特性診断応用

膜型増殖因子のER/核膜オートトランスロケーション分子機構解明とがん特性診断応用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22650228
研究種目 挑戦的萌芽研究
研究分野 総合・新領域系
総合領域
腫瘍学
腫瘍生物学
研究機関 愛媛大学
代表研究者 東山 繁樹
連携研究者 福田 信治
連携研究者 澤崎 達也
連携研究者 城 卓志
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 3,330,000 (直接経費 :3,000,000、間接経費 :330,000)
配分額（履歴） 2011年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2010年度：1,900,000 (直接経費 :1,900,000、間接経費 :0)
キーワード がん細胞の特性
膜型増殖因子
HB-EGF
amphiregulin
ER/核膜移行
レトログレード小胞輸送
膜型プロテアーゼ
抗がん剤抵抗性
胃がん
epiregulin
エンドサイトーシス
核膜移行
shedding

研究成果

[雑誌論文] A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells

Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M 2012

[雑誌論文] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin

Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashiyama S. 2012

[雑誌論文] A Disintegrin and Metalloenzyme(ADAM) 17 Activation Is Regulated byα5β1 Integrin in Kidney Mesangial Cells

Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M. 2012

[雑誌論文] Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF growth factor domain independent manner

Tanaka H, Nishioka Y, Yokoyama Y, Higashiyama S, Matsuura N, Matsuura S, Hieda M. 2012

[雑誌論文] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S. 2012

[雑誌論文] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin

Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashiyama S 2012

[雑誌論文] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S 2012

[雑誌論文] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer

Yoshida M, Shimura T, Fukuda S, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Nakazawa T, Higashiyama S, Joh T. 2012

[雑誌論文] Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF growth factor domain independent manner

Tanaka H, Nishioka Y, Yokoyama Y, Higashiyama S, Matsuura N, Matsuura S, Hieda M 2012

[学会発表] The role of monoubiqutination in the regulation of endocytosis and ectodomain shedding of a ligand of epidermal growth factor(EGF) recetor, amphiregulin

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S. 2011

[雑誌論文] Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands

Higashiyama S, Nanba D, Nakayama H, Inoue H, Fukuda S. 2011

[学会発表] HB-EGF-CTF nuclear translocation induce gastric cancer invasion

Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T 2011

[学会発表] HB-EGF-CTF nuclear translocation induce gastric cancer invasion

Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T. 2011

[学会発表] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer

Yoshida M, Shimura T, Fukuda S, Higashiyama S, Mizoshita T, Kataoka H, Joh T. 2011

[雑誌論文] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro

Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y. 2011

[学会発表] The role of monoubiqutination in the regulation of endocytosis and ectodomain shedding of a ligand of epidermal growth factor (EGF) recetor, amphiregulin

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S 2011

[雑誌論文] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts

Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ. 2011

[雑誌論文] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ. 2011

[学会発表] Ectodomain shedding of LYVE-1 : VEGF-A promotes the initial step of pathological lymphoangiogenesis

Satoshi Hirakawa, Shigeki Higashiyama 2010

[学会発表] Identification of novel molecules that regulate ectodomain shedding of EGF ligands

福田信治、中山寛尚、東山繁樹 2010

[学会発表] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death

東山繁樹、井上博文 2010

[雑誌論文] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.

Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y. 2010

[学会発表] dentification of novel molecules that regulate ectodomain shedding of EGF ligands

福田信治、中山寛尚、東山繁樹 2010

[雑誌論文] Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro

Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y. 2010

[雑誌論文] TGFβinduces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells

Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T. 2010

[雑誌論文] TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.

Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T. 2010

[学会発表] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御

東山繁樹 2010

[学会発表] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御

東山繁樹 2010

[学会発表] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death

東山繁樹、井上博文 2010