傷害脳に出現するマクロファージ様細胞BINCsの多能性幹細胞性の証明

トップ›研究者を探す›傷害脳に出現するマクロファージ様細胞BINCsの多能性幹細胞性の証明

傷害脳に出現するマクロファージ様細胞BINCsの多能性幹細胞性の証明

代表研究者	田中潤也
研究課題番号	KAKENHI-PROJECT-22390037
研究種目	基盤研究(B)
研究分野	生物系医歯薬学基礎医学生理学一般
研究機関	愛媛大学
研究分担者	矢野元
研究分担者	高橋寿明
研究分担者	杉本香奈
連携研究者	大西丘倫
連携研究者	久門良明
研究期間開始年月日	2010/4/1
研究期間終了年度	2012
研究ステータス	完了 (2012/4/1)
配分額（合計）	18,720,000 (直接経費 :14,400,000、間接経費 :4,320,000)
配分額（履歴）	2012年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000) 2011年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000) 2010年度：9,100,000 (直接経費 :7,000,000、間接経費 :2,100,000)
キーワード	マクロファージマイクログリア骨髄分化多能性神経細胞保護作用単球 BINCs 脳梗塞 NG2 パーキンソン病新規治療法幹細胞性脳損傷 Iba1 サイトカイン分化誘導

研究成果

[学会発表] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors

Yudai Ohara, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano、Nari Tei, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka 2013

[学会発表] Agents modulating neuroprotective and neurotoxic functions of microglia and their application to the pathologic brains

Junya Tanaka 2013

[雑誌論文] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions

Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi 2013

[雑誌論文] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions

Nari Tei 2013

[学会発表] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-18 Ayano Mise

Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanak 2013

[学会発表] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-18

Ayano Mise 2013

[雑誌論文] Oct-3/4 promotes migration and invasion of glioblastoma cells.

Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J. 2012

[雑誌論文] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes.

Mayorca-Guiliani AE, Yano H, Nakashiro KI, Hamakawa H, Tanaka J. 2012

[学会発表] A cytokine mixture containing GM-CSF and IL-3 targeting microglia ameliorates neurological deficits of Parkinson's disease model rats

Junya Tanaka, Mohammed E. Choudhury, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano 2012

[学会発表] 脳梗塞巣に集積するマクロファージの役割とその治療的利用

田中潤也、杉本香奈、西原佑、高橋寿明、矢野元 2012

[雑誌論文] Zonisamide up-regulated them RNAs encoding astrocytic anti-oxidative and neurotrophic factors

Choudhury ME, Sugimoto K, Kubo M, Iwaki H, Tsujii T, Kyaw WT, Nishikawa N, Nagai M, Tanaka J, Nomoto M 2012

[雑誌論文] Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children

Hitomi Hino, Hisaaki Takahashi, Yuka Suzuki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda 2012

[雑誌論文] Oct-3/4 promotes migration and invasion of glioblastoma cells

Kobayashi K 2012

[雑誌論文] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes

Mayorca-Guiliani AE 2012

[雑誌論文] Subcutaneous injection containing IL-3 and GM-CSF amelioratesstab wound-induced brain injury in rats

Nishihara T, Michihisa Ochi M, Kana Sugimoto K, Takahashi H, Yano H, Kumon Y, Ohnishi T, Tanaka J 2011

[雑誌論文] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Tasuku

Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka. 2011

[雑誌論文] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages.

NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J. 2011

[雑誌論文] A cytokine mixture of GM‐CSF and IL‐3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6‐OHDA)‐induced Parkinsonism of rats

Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J. 2011

[学会発表] 神経細胞傷害に対するグリア細胞の反応:ラット6-OHDA負荷パーキンソン病モデルを用いた検討

田中潤也, 他 2011

[雑誌論文] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages

Nakata, T., et al 2011

[雑誌論文] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats

Nishihara, T., et al 2011

[雑誌論文] A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats

Choudhry, E., et al 2011

[雑誌論文] Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain

Smirkin, A.Matsumoto, H.Takahashi, H.Inoue, A.Tagawa, M.Ohue, S.Watanabe, H.Yano, H.Kumon, Y.Ohnishi, T.Tanaka, J. 2010

[雑誌論文] Iba1+/NG2+ macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.

Anna Smirkin, Hiroaki Matsumoto, Hisaaki Takahashi, Akihiro Inoue, Masahiko Tagawa, Shiro Ohue, Hideaki Watanabe, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi and Junya TanakaJ 2010

[雑誌論文] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity

Inoue A., Takahashi, H., Harada, H., Kohno, S., Ohue, S., Kobayashi, K., Yano, H., Tanaka, J., Ohnishi, T. 2010

[雑誌論文] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.

Inoue, A., Takahashi, H., Harada, H., Kohno, S., Ohue, S., Kobayashi, K., Yano, H., Tanaka, J., Ohnishi, T. 2010

[学会発表] Generation of ramified microglia and other types of neural cells from leptomeninges

Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Junya Tanaka 2010