トップ研究者を探す肝細胞がんの発がんおよび進展に関わるPKR関連分子eIF2の標的治療の可能性

肝細胞がんの発がんおよび進展に関わるPKR関連分子eIF2の標的治療の可能性

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21K08008
研究種目 基盤研究(C)
研究分野
研究機関 愛媛大学
代表研究者 日浅 陽一
研究期間 開始年月日 2021/4/1
研究期間 終了年度 2023
研究ステータス 交付 (2022/4/1)
配分額(合計) 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額(履歴) 2023年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2022年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2021年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード eIF2-alpha
eIF2-beta
eIF2-gamma
PKR
PERK
肝細胞癌
eIF2B
protein kinase R
hepatocellular carcinoma

研究成果

[雑誌論文] Early experience of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma BCLC‐B stage patients classified as beyond up to seven criteria ? Multicenter analysis

Hiraoka A、Kumada T、Tada T、Hirooka M、Kariyama K、Tani J、Atsukawa M、Takaguchi K、Itobayashi E、Fukunishi S、Tsuji K、Ishikawa T、Tajiri K、Ochi H、Yasuda S、Toyoda H、Ogawa C、Nishimura T、Hatanaka T、Kakizaki S、Shimada N、Kawata K、Naganuma A、Tanaka T、Ohama H、Nouso K、Morishita A、Hiasa Y、Kudo M、et al. 2022

[雑誌論文] Atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma: Early clinical experience

Hiraoka A、Kumada T、Tada T、Hirooka M、Kariyama K、Tani J、Atsukawa M、Takaguchi K、Itobayashi E、Fukunishi S、Tsuji K、Ishikawa T、Tajiri K、Ochi H、Yasuda S、Toyoda H、Ogawa C、Nishimura T、Hatanaka T、Ohama H、Nouso K、Morishita A、Tsutsui A、Nagano T、Itokawa N、Hiasa Y、Kudo M、et al. 2022

[雑誌論文] Glasgow prognostic score predicts survival in patients with unresectable hepatocellular carcinoma treated with lenvatinib: a multicenter analysis

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Comparative efficacy and safety of atezolizumab and bevacizumab between hepatocellular carcinoma patients with viral and non‐viral infection: A Japanese multicenter observational study

Hatanaka Takeshi、Kakizaki Satoru、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] C-reactive protein to albumin ratio predicts survival in patients with unresectable hepatocellular carcinoma treated with lenvatinib

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Clinical Usefulness of Surgical Resection Including the Complementary Use of Radiofrequency Ablation for Intermediate-Stage Hepatocellular Carcinoma

Ohama Hideko、Hiraoka Atsushi、Tada Fujimasa、Hiasa Yoichi、et al. 2022

[雑誌論文] Prognostic impact of C-reactive protein and alpha-fetoprotein in immunotherapy score in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab: a multicenter retrospective study

Hatanaka Takeshi、Kakizaki Satoru、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Neutrophil-lymphocyte ratio predicts early outcomes in patients with unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab: a multicenter analysis

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Does first‐line treatment have prognostic impact for unresectable HCC? -Atezolizumab plus bevacizumab versus lenvatinib

Hiraoka Atsushi、Kumada Takashi、Tada Toshifumi、Hiasa Yoichi、et al. 2022

[雑誌論文] The hepatocellular carcinoma modified Gustave Roussy Immune score (HCC-GRIm score) as a novel prognostic score for patients treated with atezolizumab and bevacizumab: A multicenter retrospective analysis

Hatanaka Takeshi、Naganuma Atsushi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Therapeutic efficacy of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma in patients with Child‐Pugh class A or B liver function in real‐world clinical practice

Tanaka Takaaki、Hiraoka Atsushi、Tada Toshifumi、Hiasa Yoichi、et al. 2022

[雑誌論文] A Novel SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease (CHESS2102): An International Multicenter Cohort Study

Liu Chuan、Cao Zhujun、Yan Huadong、Hiasa Yoichi、et al. 2022

[雑誌論文] New prognostic system based on inflammation and liver function predicts prognosis in patients with advanced unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab: A validation study

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Clinical Predictor of Urinary Protein as Adverse Event Associated with Atezolizumab plus Bevacizumab Treatment for Unresectable Hepatocellular Carcinoma

Hiraoka Atsushi、Kumada Takashi、Tada Toshifumi、Hiasa Yoichi、et al. 2022

[雑誌論文] Development and validation of a modified albumin?bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab

Hatanaka Takeshi、Kakizaki Satoru、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Association of early bevacizumab interruption with efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma: A landmark analysis

Hatanaka Takeshi、Hiraoka Atsushi、Tada Toshifumi、Hiasa Yoichi、et al. 2022

[雑誌論文] Comparison of Surgical Resection and Percutaneous Ultrasonographic Guided Radiofrequency Ablation for Initial Recurrence of Hepatocellular Carcinoma in Early Stage following Curative Treatment

Ohama Hideko、Hiraoka Atsushi、Tada Fujimasa、Hiasa Yoichi、et al. 2022

[雑誌論文] Nutritional Status Is Associated with Prognosis in Patients with Advanced Unresectable Hepatocellular Carcinoma Treated with Atezolizumab plus Bevacizumab

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Safety and efficacy of atezolizumab plus bevacizumab in elderly patients with hepatocellular carcinoma: A multicenter analysis

Tada Toshifumi、Kumada Takashi、Hiraoka Atsushi、Hiasa Yoichi、et al. 2022

[雑誌論文] Efficacy of lenvatinib for unresectable hepatocellular carcinoma based on background liver disease etiology: multi-center retrospective study

Hiraoka A、Kumada T、Tada T、Tani J、Kariyama K、Fukunishi S、Atsukawa M、Hirooka M、Tsuji K、Ishikawa T、Takaguchi K、Itobayashi E、Tajiri K、Shimada N、Shibata H、Ochi H、Kawata K、Yasuda S、Toyoda H、Aoki T、Tanaka T、Ohama H、Hiasa Y、Kudo M、et al. 2021

[雑誌論文] Lenvatinib versus Sorafenib as first‐line treatment in hepatocellular carcinoma: A multi‐institutional matched case‐control study

Rimini M、Shimose S、Lonardi S、Tada T、Masi G、Iwamoto H、Lai E、Burgio V、Hiraoka A、Ishikawa T、Solda C、Shirono T、Vivaldi C、Takaguchi K、Shimada N、Astara G、Koga H、Nouso K、Joko K、Torimura T、Hiasa Y、Salani F、Scartozzi M、Cascinu S、Casadei GA. 2021

[雑誌論文] Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib

Rapposelli IG、Tada T、Shimose S、Burgio V、Kumada T、Iwamoto H、Hiraoka A、Niizeki T、Atsukawa M、Koga H、Hirooka M、Torimura T、Iavarone M、Tortora R、Campani C、Lonardi S、Tamburini E、Piscaglia F、Masi G、Cabibbo G、Giuseppe FF、Silletta M、Tsuji K、Ishikawa T、Hiasa Y、Casadei GA、et al. 2021

[雑誌論文] Radiofrequency Ablation Covering the Entire Tumor Blood Drainage Area Improves Survival in Hepatocellular Carcinoma

Hirooka M、Koizumi Y、Tanaka T、Sunago K、Nakamura Y、Watanabe T、Yoshida O、Tokumoto Y、Abe M、Hiasa Y. 2021

[雑誌論文] Impact of Early Lenvatinib Administration on Survival in Patients with Intermediate-Stage Hepatocellular Carcinoma: A Multicenter, Inverse Probability Weighting Analysis

Tada T、Kumada T、Hiraoka A、Michitaka K、Atsukawa M、Hirooka M、Tsuji K、Ishikawa T、Takaguchi K、Kariyama K、Itobayashi E、Tajiri K、Shimada N、Shibata H、Ochi H、Yasuda S、Toyoda H、Fukunishi S、Ohama H、Kawata K、Nakamura S、Nouso K、Tsutsui A、Nagano T、Hiasa Y、et al. 2021

[雑誌論文] Impact of modified albumin?bilirubin grade on survival in patients with HCC who received lenvatinib

Tada T、Kumada T、Hiraoka A、Atsukawa M、Hirooka M、Tsuji K、Ishikawa T、Takaguchi K、Kariyama K、Itobayashi E、Tajiri K、Shimada N、Shibata H、Ochi H、Yasuda S、Toyoda H、Fukunishi S、Ohama H、Kawata K、Tani J、Nakamura S、Nouso K、Tsutsui A、Nagano T、Takaaki T、Hiasa Y、et al. 2021

[雑誌論文] Therapeutic efficacy of lenvatinib as third‐line treatment after regorafenib for unresectable hepatocellular carcinoma progression

Hiraoka A、Kumada T、Hatanaka T、Tada T、Kariyama K、Tani J、Fukunishi S、Atsukawa M、Hirooka M、Tsuji K、Ishikawa T、Takaguchi K、Itobayashi E、Tajiri K、Shimada N、Shibata H、Ochi H、Kawata K、Yasuda S、Toyoda H、Ogawa C、Tamai T、Kakizaki S、Tojima H、Hiasa Y、Kudo M、et al. 2021