トップ›研究者を探す›脳動脈瘤形成・増大におけるスタチンの二面性作用

脳動脈瘤形成・増大におけるスタチンの二面性作用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21591844
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
脳神経外科学
研究機関 徳島大学
代表研究者 里見 淳一郎
研究分担者 永廣 信治
研究分担者 兼松 康久
研究分担者 八木 謙次
研究分担者 多田 恵曜
研究分担者 佐田 政隆
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2011年度：130,000 (直接経費 :100,000、間接経費 :30,000)
2010年度：2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
2009年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
キーワード 脳動脈瘤
高血圧
エストロゲン
炎症
酸化ストレス

研究成果

[学会発表] Excessive salt-intake exacerbates ischemic brain damage independent of blood pressure

Sumiyoshi M, Kinouchi T, Tsutsumi T, Kitazato K, Shimada K, Matsushita N, Kanematsu Y, Satomi J, Nagahiro S 2012

[学会発表] ACTIVATION OF NUCLEAR RECEPTORS ON NEUROPROTECTION AFTER EXPERIMENTAL CEREBRAL ISCHEMIA IN FEMALE RATS

Kohrai M, Kitazato KT., Kinouchi T, Shimada K, Sumiyoshi M, Matsushita N, Kanematsu Y, Satomi J, Kageji T, Nagahiro S 2012

[学会発表] Nagahiro S Influence of sodium retention on the formation of cerebral aneurysm

Matsushita N, Kitazato K, Shimada K, Kinouchi T, Kanematsu Y, Satomi J 2012

[雑誌論文] Nagahiro S Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats

Kinouchi T, Kitazato KT, Shimada K, Yagi K, Tada Y, Matsushita N, Sumiyoshi M, Satomi J, Kageji T 2012

[学会発表] Vascular Mineralcorticoid Receptor Antagonism Combined with A Decrease in Salt-intake By Eplerenone Inhibits Cerebral Aneurysm without Affecting Blood Pressure

Kitazato KT, Tada Y, Kanematsu Y, Satomi J., Nagahiro S 2011

[雑誌論文] Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats

Tada Y, Kitazato KT, Yagi K, Shimada K, Matsushita N, Kinouchi T, Kanematsu Y, Satomi J, Kageji T, Nagahiro S 2011

[学会発表] High salt-intake under hypoestrogenicity exacerbates ischemic brain damage

Sumiyoshi M, Kitazato KT, Kinouchi T, Tsutsumi T, Shimada K, Matsushita N, Kanematsu Y., Satomi J., Nagahiro S 2011

[雑誌論文] A mouse model of intracranial aneurysm : technical considerations

Tada Y, Kanematsu Y, Kanematsu M, Nuki Y, Liang EI, Wada K, Makino H, Hashimoto T 2011

[雑誌論文] Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats

Tada Y, et al 2011

[雑誌論文] Activation of estrogen receptor-αand of angiotensin-converting enzyme 2 suppresses ischemic brain damage in oophorectomized rats

Shimada K, Kitazato KT, Kinouchi T, Yagi K, Tada Y, Satomi J, Kageji T, Nagahiro S 2011

[雑誌論文] Kruppel-like Zinc-Finger Transcription Factor 5(KLF5) Is Highly Expressed in Large and Giant Unruptured Cerebral Aneurysms

Nakajima N, Nagahiro S, Sano T, Satomi J, Tada Y, Yagi K, Kitazato KT, Satoh K 2011

[雑誌論文] Statins promote the growth of experimentally induced cerebral aneurysms in estrogen deficient rats.

Tada Y, Kitazato KT, Satomi J, Nagahiro S, et al. 2011

[雑誌論文] Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats

Tada Y, Yagi K, Kitazato KT, Tamura T, Kinouchi T, Shimada K, Matsushita N, Nakajima N, Satomi J, Kageji T, Nagahiro S 2010

[雑誌論文] Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats

Yagi K, Tada Y, Kitazato KT, Tamura T, Satomi J, Nagahiro S 2010

[雑誌論文] Incidence and clinical correlation of intracranial hemorrhages observed by 3-tesla gradient echo T(2)*-weighted images following intravenous thrombolysis with recombinant tissue plasminogen activator

Harada M, Morita N, Uno M, Satomi J, Izumi Y, Asanuma K, Nishitani H, Kaji R, Nagahiro S 2010

[雑誌論文] Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats

Tamura T, Jamous MA, Kitazato KT, Yagi K, Tada Y, Uno M, Nagahiro S 2009

[雑誌論文] Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats

Tada Y, Kitazato KT, Tamura T, Yagi K, Shimada K, Kinouchi T, Satomi J, Nagahiro S 2009