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多田恵曜

徳島大学

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2024年11月14日更新

職名: 講師
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学歴: 2000/3: 徳島大学医学部医学科卒業
学位: 博士(医学) (徳島大学) (2009年9月)
職歴・経歴: 〜: 徳島大学医員, 病院 (-2006.9.)
2007/6: 徳島大学リサーチ・アシスタント, 医学部 (-2008.3.)
2009/4: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2009.4.)
2009/5: 徳島大学助教, 病院 (-2011.9.)
2012/4: 徳島大学特任助教, 病院 (-2012.9.)
2012/10: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2015.9.)
2015/10: 徳島大学助教, 病院 (-2016.4.)
2016/5: 徳島大学講師, 大学院医歯薬学研究部 (-2017.9.)
2017/10: 徳島大学特任講師, 病院 (-2024.3.)
2024/4: 徳島大学講師, 大学院医歯薬学研究部

専門分野・研究分野: 医学 (Medicine)

研究者総覧で最新データを確認する

2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: 神経・精神・行動コース (学部)
臨床病理学総論 (学部)
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2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)

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論文

Eiji Shikata, Takeshi Miyamoto, Tadashi Yamaguchi, Izumi Yamaguchi, Hiroshi Kagusa, Daiki Gotoh, Kenji Shimada, Yoshiteru Tada, Kenji Yagi, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi :
An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with infammatory changes in rat brain harboring cerebral aneurysms prone to rupture,
Journal of Neuroinflammation, Vol.19, No.161, 161, 2022.

(要約): An aneurysmal subarachnoid hemorrhage is a devastating event. To establish an effective therapeutic strategy, its pathogenesis must be clarified, particularly the pathophysiology of brain harboring intracranial aneurysms (IAs). To elucidate the pathology in brain harboring IAs, we examined the significance of the receptor for advanced glycation end-products (RAGE)/mineralocorticoid receptor (MR) pathway and Na/K-ATPase (ATP1α3). Ten-week-old female rats were subjected to oophorectomy as well as hypertension and hemodynamic changes to induce IAs, and were fed a high-salt diet. Brain damage in these rats was assessed by inflammatory changes in comparison to sham-operated rats fed a standard diet. Six weeks after IA induction (n = 30), irregular morphological changes, i.e., an enlarged vessel diameter and vascular wall, were observed in all of the left posterior cerebral arteries (Lt PCAs) prone to rupture. Approximately 20% of rats had ruptured IAs within 6 weeks. In brain harboring unruptured IAs at the PCA, the mRNA levels of RAGE and MR were higher, and that of ATP1α3 was lower than those in the sham-operated rats (p < 0.05, each). Immunohistochemically, elevated expression of RAGE and MR, and decreased expression of ATP1α3 were observed in the brain parenchyma adjacent to the Lt PCA, resulting in increased Iba-1 and S100B expression that reflected the inflammatory changes. There was no difference between the unruptured and ruptured aneurysm rat groups. Treatment with the MR antagonist esaxerenone abrogated these changes, and led to cerebral and vascular normalization and prolonged subarachnoid hemorrhage-free survival (p < 0.05). Regulation of the imbalance between the RAGE/MR pathway and ATP1α3 may help attenuate the damage in brain harboring IAs, and further studies are warranted to clarify the significance of the down-regulation of the MR/RAGE pathway and the up-regulation of ATP1α3 for attenuating the pathological changes in brain harboring IAs.
(キーワード): Aneurysm, Ruptured / Animals / Brain / Female / HMGB1 Protein / Intracranial Aneurysm / Rats / Receptor for Advanced Glycation End Products / Receptors, Mineralocorticoid / Sodium-Potassium-Exchanging ATPase / Subarachnoid Hemorrhage
(徳島大学機関リポジトリ): ● Metadata: 117703
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12974-022-02526-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35725479; ● Search Scopus @ Elsevier (PMID): 35725479; ● Search Scopus @ Elsevier (DOI): 10.1186/s12974-022-02526-7

(徳島大学機関リポジトリ: 117703, DOI: 10.1186/s12974-022-02526-7, PubMed: 35725479) Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, Izumi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Masaaki Korai, Keiko T. Kitazato, Yasuhisa Kanematsu and Yasushi Takagi :
Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats,
Journal of Neurosurgery, 1-8, 2022.

(要約): Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.
(徳島大学機関リポジトリ): ● Metadata: 117700
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2022.4.JNS212945
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35594890; ● Search Scopus @ Elsevier (PMID): 35594890; ● Search Scopus @ Elsevier (DOI): 10.3171/2022.4.JNS212945

(徳島大学機関リポジトリ: 117700, DOI: 10.3171/2022.4.JNS212945, PubMed: 35594890) Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Takeshi Miyamoto, Tadashi Yamaguchi, Hiroshi Kagusa, Kenji Shimada, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu and Yasushi Takagi :
Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?,
Brain Hemorrhages, Vol.137, No.6, 1707-1717, 2022.

(徳島大学機関リポジトリ): ● Metadata: 118951
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.hest.2023.10.005
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85175417356

(徳島大学機関リポジトリ: 118951, DOI: 10.1016/j.hest.2023.10.005, Elsevier: Scopus) Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging,
Journal of the Neurological Sciences, Vol.436, 1-8, 2022.

(要約): Arterial spin labeling (ASL) and diffusion-weighted imaging (DWI) are useful for assessing hyperperfusion and cytotoxic edema, respectively, caused by acute seizures. This study investigated the clinical characteristics associated with normal ASL findings and DWI abnormalities in patients with acute seizures. Overall, 41 patients with ASL and DWI images that were obtained within 48 h of focal onset seizure diagnosis, due to epilepsy or acute symptomatic seizures, were divided into groups based on initial ASL findings (ASL-negative vs. ASL-positive), and DWI abnormalities (DWI-negative vs. DWI-positive). The diagnosis was made based on seizure semiology, electroencephalography, and conventional imaging modalities. ASL and DWI abnormalities were based on visual assessment. Of the 41 patients, eight (19.5%) displayed normal ASL findings. The proportion of patients with focal aware seizures (FAS) was significantly higher among ASL-negative patients (62.5%) than that in ASL-positive patients (15.2%); the proportion of patients with focal impaired awareness seizures (FIAS) was significantly lower among ASL-negative patients (12.5%) than that among ASL-positive patients (57.6%). Hyperintensity findings on DWI were observed in 12 patients (29.3%, DWI-positive). The proportion of patients with FIAS was significantly higher among DWI-positive patients (75.0%) than that among DWI-negative patients (37.9%). Multivariate analysis revealed that FAS and FIAS were associated with normal ASL findings (odds ratio [OR]: 21.37, P = 0.010) and DWI abnormalities (OR = 6.11, P = 0.028). A diagnosis of seizures should not be excluded based on normal ASL findings, especially in patients with FAS. FIAS may be a risk factor for neuronal damage caused by seizure activity.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2022.120223
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35279594; ● Summary page in Scopus @ Elsevier: 2-s2.0-85126008460

(DOI: 10.1016/j.jns.2022.120223, PubMed: 35279594, Elsevier: Scopus) Izumi Yamaguchi, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Yoshiteru Tada, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Hiroshi Kagusa, Yoko Yamamoto, Taku Matsuda, Keiko T. Kitazato, Yoshihiro Okayama and Yasushi Takagi :
Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study,
Journal of Clinical Neuroscience, Vol.94, 244-249, 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2021.10.037
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2021.10.037

(DOI: 10.1016/j.jocn.2021.10.037) Kenji Shimada, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yoshiteru Tada, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi :
Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations,
World Neurosurgery, E1-E7, 2021.

(要約): Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs.
(徳島大学機関リポジトリ): ● Metadata: 116871
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2021.08.118
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34478890; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115331132

(徳島大学機関リポジトリ: 116871, DOI: 10.1016/j.wneu.2021.08.118, PubMed: 34478890, Elsevier: Scopus) Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi :
Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report.,
Surgical Neurology International, Vol.12, No.347, 2021.

(要約): The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms.
(徳島大学機関リポジトリ): ● Metadata: 119411
(出版サイトへのリンク): ● Publication site (DOI): 10.25259/SNI_533_2021
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487; ● Search Scopus @ Elsevier (PMID): 34345487; ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021

(徳島大学機関リポジトリ: 119411, DOI: 10.25259/SNI_533_2021, PubMed: 34345487) Shotaroh Yoshioka, Takeshi Miyamoto, Junichiro Satomi, Yoshiteru Tada, Kenji Yagi, Kenji Shimada, Koji Naruishi, Eiji Shikata, Izumi Yamaguchi, Tadashi Yamaguchi, Masaaki Korai, Yoshihiro Okayama, Masafumi Harada, Keiko Kitazato, Yasuhisa Kanematsu, Shinji Nagahiro and Yasushi Takagi :
Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage,
Neurosurgery Open, Vol.1, No.3, 1-9, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115292
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/neuopn/okaa007
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1093/neuopn/okaa007

(徳島大学機関リポジトリ: 115292, DOI: 10.1093/neuopn/okaa007) Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Naoki Akazawa, Yasushi Takagi and Shinji Nagahiro :
Action observation treatment improves gait ability in subacute to convalescent stroke patients.,
Journal of Clinical Neuroscience, Vol.75, 55-61, 2020.

(要約): The aim of this study was to investigate the effects of action observation treatment (AOT) on gait ability in patients with subacute to convalescent stroke. Sixteen patients with subacute stroke were divided into a control group (n = 8) and AOT group (n = 8) when admitted to the convalescent ward. The control group received a conventional rehabilitation only. In addition to conventional rehabilitation, the AOT received AOT for 3 months (30 min per day 5 times per week). The AOT involved observing the action of another subject in a comfortable gait situation from the front, sides, and back via video and conducting the actual action. All participants were assessed during the main-assessment period, which included a baseline (i.e., when admitted to the convalescent ward) and 1, 2, and 3 months after baseline. The sub-assessment period at 2 and 3 months after baseline was conducted with participants who could walk independently. The main outcomes of the main-assessment and sub-assessment periods were Functional Ambulation Classification (FAC) and the 10-m walk test (10MWT), respectively. With respect to the FAC, we used a split plot design analysis of covariance to test the interaction between assessment time and group. There was no significant interaction between assessment time and group in FAC. However, a significant improvement of the 10MWT in the sub-assessment period was observed in the AOT group, but not the control group. Our results indicate that AOT may be an effective therapy for patients with subacute to convalescent stroke who can walk independently.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2020.03.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32234334; ● Search Scopus @ Elsevier (PMID): 32234334; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2020.03.031

(DOI: 10.1016/j.jocn.2020.03.031, PubMed: 32234334) Tadashi Yamaguchi, Takeshi Miyamoto, keiko Kitazato, Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshihito Matsuzaki, Yasuhisa Kanematsu and Yasushi Takagi :
Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model,
Journal of Neurosurgery, 2019.

(要約): The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture.
(徳島大学機関リポジトリ): ● Metadata: 113804
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2019.6.JNS19777
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31518986; ● Search Scopus @ Elsevier (PMID): 31518986; ● Search Scopus @ Elsevier (DOI): 10.3171/2019.6.JNS19777

(徳島大学機関リポジトリ: 113804, DOI: 10.3171/2019.6.JNS19777, PubMed: 31518986) Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Hideo Mure, Kenji Shimada, Toshiyuki Okazaki, Masaaki Korai, Noki Akazawa, Yuki Matsumoto, Yuki Matsumoto, Yasushi Takagi and Shinji Nagahiro :
Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons.,
Journal of Clinical Neuroscience, Vol.60, 79-83, 2019.

(要約): The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training.
(キーワード): Adult / Brain / Exercise Therapy / Female / Gait / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Mirror Neurons / Stroke / Stroke Rehabilitation
(徳島大学機関リポジトリ): ● Metadata: 113267
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jocn.2018.09.035
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30318398; ● Search Scopus @ Elsevier (PMID): 30318398; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2018.09.035

(徳島大学機関リポジトリ: 113267, DOI: 10.1016/j.jocn.2018.09.035, PubMed: 30318398) Shinji Nagahiro, Yoshiteru Tada, Junichiro Satomi, Tomoya Kinouchi, Kazuyuki Kuwayama, Kenji Yagi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Kenji Shimada, Masaaki Korai, Hideo Mure, Y Okayama, Takashi Abe, Masafumi Harada, Keiko T. Kitazato and Yasuhisa Kanematsu :
Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study.,
Journal of Stroke & Cerebrovascular Diseases, Vol.27, No.8, 2134-2140, 2018.

(要約): Currently there are no pharmacological therapies for patients with unruptured cerebral aneurysms. Elsewhere we showed that the mineralocorticoid receptor antagonist eplerenone prevented the formation of cerebral aneurysms in our ovariectomized hypertensive aneurysm rat model. The current pilot study evaluated whether it can be used to prevent the growth and rupture of cerebral aneurysms in hypertensive patients. Between August 2011 and May 2014, we enrolled 82 patients with 90 aneurysms in an open-label uncontrolled clinical trial. All provided prior informed consent for inclusion in this study, and all were treated with eplerenone (25-100 mg/d). The primary end points of our study were the rupture and enlargement of the cerebral aneurysms. Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21.3 months (153.4 aneurysm-years); 12 patients (15.0%) permanently discontinued taking the drug. One month after the start of eplerenone administration and throughout the follow-up period, eplerenone kept the blood pressure within the normal range. Most notably, no aneurysms smaller than 9 mm ruptured or enlarged. However, of 2 large thrombosed aneurysms, 1 enlarged and the other ruptured. The overall annual rupture rate was .65%; it was 13.16% for aneurysms larger than 10 mm; the overall annual rate for reaching the primary end points was 1.30%. Our observations suggest that eplerenone may help to prevent the growth and rupture of unruptured cerebral aneurysms smaller than 9 mm. To assess its potential long-term clinical benefits, large clinical trials are needed.
(キーワード): Aged / Aneurysm, Ruptured / 脳 (brain) / Disease Progression / 女性 (female) / Follow-Up Studies / Humans / Intracranial Aneurysm / 男性 (male) / Mineralocorticoid Receptor Antagonists / Neuroprotective Agents / Pilot Projects / Spironolactone / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 115570
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2018.03.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29622372; ● Summary page in Scopus @ Elsevier: 2-s2.0-85049537109

(徳島大学機関リポジトリ: 115570, DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.008, PubMed: 29622372, Elsevier: Scopus) Yasuhisa Kanematsu, Junichiro Satomi, Masaaki Korai, Toshiyuki Okazaki, Idumi Yamaguchi, Yoshiteru Tada, Masaaki Uno, Shinji Nagahiro and Yasushi Takagi :
Flow Alteration Therapy for Ruptured Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery,
Neurologia Medico-Chirurgica, Vol.58, 341-349, 2018.

(要約): Surgery for- and endovascular treatment of vertebral artery (VA) dissecting aneurysms involving the origin of the posterior inferior cerebellar artery (PICA) remain challenging. Their ideal treatment is complete isolation of the aneurysm by surgical or endovascular trapping plus PICA reconstruction. However, postoperative lower cranial nerve palsy and medullary infarction are potential complications. We report four patients with VA dissecting aneurysms involving the PICA origin who were treated by occipital artery (OA)-PICA bypass followed by proximal occlusion of the VA and clip ligation of the PICA origin instead of trapping. There were no procedural or ischemic complications. In all patients, angiography performed 2-3 weeks later showed good patency of the bypass graft and complete obliteration of the aneurysm. During the follow-up period ranging from 1 to 14 years, none experienced bleeding. Although retrograde blood flow to the dissecting aneurysm persisted in the absence of trapping, iatrogenic lower cranial nerve injury could be avoided. The decrease in aneurysmal flow might elicit spontaneous thrombosis and prevent aneurysmal rerupture. Our technique might be less invasive than aneurysmal trapping and help to prevent rebleeding.
(徳島大学機関リポジトリ): ● Metadata: 119189
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2018-0076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29998934; ● Summary page in Scopus @ Elsevier: 2-s2.0-85051865821

(徳島大学機関リポジトリ: 119189, DOI: 10.2176/nmc.oa.2018-0076, PubMed: 29998934, Elsevier: Scopus) Tomoya Kinouchi, Keiko T. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Yoshitaka Kurashiki, Junichiro Satomi, Masataka Sata and Shinji Nagahiro :
Correction to: Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats.,
Translational Stroke Research, Vol.9, No.3, 317, 2017.

(要約): In the original publication of the article, the second author (Keiko T. Kitazato) was missing.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12975-017-0589-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29177991; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035015467

(DOI: 10.1007/s12975-017-0589-4, PubMed: 29177991, Elsevier: Scopus) Hidetsugu Maekawa, Yoshiteru Tada, Kenji Yagi, Takeshi Miyamoto, Kitazato T. Keiko, Masaaki Korai, Junichiro Satomi, Tomoki Hashimoto and Shinji Nagahiro :
Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats.,
Journal of Neuroinflammation, Vol.2, No.14, 197, 2017.

(要約): Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen replacement therapy appears to reduce this risk but is associated with significant side effects. We tested our hypothesis that bazedoxifene, a clinically used selective estrogen receptor (ER) modulator with fewer estrogenic side effects, reduces cerebral aneurysm rupture in a new model of ovariectomized rats. Ten-week-old female Sprague-Dawley rats were subjected to ovariectomy, hemodynamic changes, and hypertension to induce aneurysms (ovariectomized aneurysm rats) and treated with vehicle or with 0.3 or 1.0 mg/kg/day bazedoxifene. They were compared with sham-ovariectomized rats subjected to hypertension and hemodynamic changes (HT rats). The vasoprotective effects of bazedoxifene and the mechanisms underlying its efficacy were analyzed. During 12 weeks of observation, the incidence of aneurysm rupture was 52% in ovariectomized rats. With no effect on the blood pressure, treatment with 0.3 or 1.0 mg/kg/day bazedoxifene lowered this rate to 11 and 17%, almost the same as in HT rats (17%). In ovariectomized rats, the mRNA level of ERα, ERβ, and the tissue inhibitor of metalloproteinase-2 was downregulated in the cerebral artery prone to rupture at 5 weeks after aneurysm induction; the mRNA level of interleukin-1β and the matrix metalloproteinase-9 was upregulated. In HT rats, bazedoxifene restored the mRNA level of ERα and ERβ and decreased the level of interleukin-1β and matrix metalloproteinase-9. These findings suggest that bazedoxifene was protective against aneurysmal rupture by alleviating the vascular inflammation and degradation exacerbated by the decrease in ERα and ERβ. Our observation that bazedoxifene decreased the incidence of aneurysmal rupture in ovariectomized rats warrants further studies to validate this response in humans.
(キーワード): Animals / 血圧 (blood pressure) / Cerebral Arteries / Cytokines / Disease Models, Animal / Dose-Response Relationship, Drug / Estrogen Receptor alpha / Estrogen Receptor beta / Female / Gene Expression Regulation / 高血圧 (hypertension) / Indoles / Intracranial Aneurysm / Matrix Metalloproteinase 2 / Ovariectomy / RNA, Messenger / Rats / Rats, Sprague-Dawley / Salts / Selective Estrogen Receptor Modulators / Tissue Inhibitor of Metalloproteinase-2
(徳島大学機関リポジトリ): ● Metadata: 111431
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12974-017-0966-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28969701; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030714321

(徳島大学機関リポジトリ: 111431, DOI: 10.1186/s12974-017-0966-7, PubMed: 28969701, Elsevier: Scopus) Yasuhisa Kanematsu, Junichiro Satomi, Kazuyuki Kuwayama, Izumi Yamaguchi, Shotaroh Yoshioka, Tomoya Kinouchi, Yoshiteru Tada, Nobuaki Yamamoto, Shunji Matsubara, Kenji Shono and Shinji Nagahiro :
Treatment Outcome of Carotid Artery Stenting Underwent within 14 Days of Stroke Onset - Consideration of Safety and Efficacy of Urgent Carotid Artery Stenting for Neurologically Progressing Patients,
Neurologia Medico-Chirurgica, Vol.57, No.6, 278-283, 2017.

(要約): As the safety and effectiveness of urgent carotid artery stenting (CAS) for neurologically progressing patients remain controversial, we retrospectively analyzed the outcome of urgent CAS based on the patients' pathophysiological condition and neuroimaging findings. We divided 71 patients who underwent CAS within 14 days of stroke onset into two groups. Group 1 (n = 35) was comprised of patients with progressing neurologic signs and a reversible ischemic penumbra on magnetic resonance images (MRI). They were treated by urgent CAS. Group 2 (n = 36) was neurologically stable and underwent prophylactic CAS. In all patients we recorded the National Institutes of Health Stroke Scale (NIHSS) score and the modified Rankin scale (mRS). Urgent CAS resulted in significant improvement in the NIHSS score, when compared before and after CAS in group 1 (5.3 ± 4.3, P < 0.01). The rate of good outcomes (mRS 0-2 at 3 months post-CAS) was 48.6% in group 1, and 75% in group 2. The cumulative incidence of ipsilateral stroke between 31 days and 1 year was 5.9% in group 1, and 0% in group 2. The procedural complication rate was similar in both groups (group 1: 5.7%, n = 2; group 2: 5.6%, n = 2). No patient suffered a symptomatic intracerebral hemorrhage. When the pathophysiological status and neuroimaging findings are used to determine patient eligibility for urgent CAS, this treatment improve neurologic outcome and can be performed as safely as prophylactic CAS in our cohort of patients with acute ischemic stroke.
(徳島大学機関リポジトリ): ● Metadata: 119202
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.oa.2016-0236
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381652; ● Search Scopus @ Elsevier (PMID): 28381652; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2016-0236

(徳島大学機関リポジトリ: 119202, DOI: 10.2176/nmc.oa.2016-0236, PubMed: 28381652) Shu Sogabe, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Shotaroh Yoshioka, Yoshifumi Mizobuchi, Hideo Mure, Izumi Yamaguchi, Takashi Abe, Nobuaki Yamamoto, Keiko Kitazato, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment,
Neuroradiology, Vol.59, No.6, 587-595, 2017.

(要約): Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer than the post-labeling delay, labeled spins are visible on ASL images as bright, high intra-arterial signals (IASs); such signals were found within occluded vessels of patients with acute ischemic stroke. The identification of the occluded segment in the internal carotid artery (ICA) is crucial for endovascular treatment. We tested our hypothesis that high IASs on ASL images can predict the occluded segment. Our study included 13 patients with acute ICA occlusion who had undergone angiographic and ASL studies within 48 h of onset. We retrospectively identified the high IAS on ASL images and angiograms and recorded the occluded segment and the number of high IAS-positive slices on ASL images. The ICA segments were classified as cervical (C1), petrous (C2), cavernous (C3), and supraclinoid (C4). Of seven patients with intracranial ICA occlusion, five demonstrated high IASs at C1-C2, suggesting that high IASs could identify stagnant flow proximal to the occluded segment. Among six patients with extracranial ICA occlusion, five presented with high IASs at C3-C4, suggesting that signals could identify the collateral flow via the ophthalmic artery. None had high IASs at C1-C2. The mean number of high IAS-positive slices was significantly higher in patients with intra- than extracranial ICA occlusion. High IASs on ASL images can identify slow stagnant and collateral flow through the ophthalmic artery in patients with acute ICA occlusion and help to predict the occlusion site.
(徳島大学機関リポジトリ): ● Metadata: 111444
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00234-017-1828-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28397019; ● Search Scopus @ Elsevier (PMID): 28397019; ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-017-1828-9

(徳島大学機関リポジトリ: 111444, DOI: 10.1007/s00234-017-1828-9, PubMed: 28397019) Kenji Shono, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Nobuaki Yamamoto, Yuishin Izumi, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Optimal Timing of Diffusion-Weighted Imaging to Avoid False-Negative Findings in Patients With Transient Ischemic Attack,
Stroke, Vol.48, No.7, 1990-1992, 2017.

(要約): We aimed to investigate the optimal timing of diffusion-weighted imaging (DWI) in patients with transient ischemic attack (TIA). Seventy-three consecutive patients with TIA underwent DWI on admission (initial DWI) and at 24 hours after admission (second DWI). Patients were divided into 2 groups based on initial DWI findings in relation to the second examination: false negative (group 1) and other (group 2). The probability of initial false-negative findings was determined for each hour from TIA onset to initial DWI. Multivariate analysis was used to evaluate the independent risk factors associated with false-negative findings on initial DWI. Of the 73 patients examined (56 men; mean age, 68 years), 9 (12%) were categorized into group 1. The latency from TIA onset to initial DWI was 1.7±0.6 hours for group 1 (range, 1-2.8 hours) and 3.3±2.6 hours for group 2 (range, 35 minutes to 12 hours). The probability of false-negative findings on initial DWI decreased in a time-dependent manner (25%, 21%, and 7% for 1, 2, and 3 hours, respectively), and no false-negative findings were observed on initial DWI performed at >3 hours from symptom onset. Short latency (2 hours) from TIA onset to initial DWI was an independent risk factor related to false-negative findings (odds ratio, 13.11; 95% confidence interval, 1.07-161.38; P=0.045). If the duration between TIA symptom onset and initial DWI is <2 hours, a repeat examination should be performed to minimize the risk of false-positive findings.
(キーワード): Aged / Aged, 80 and over / Diffusion Magnetic Resonance Imaging / False Negative Reactions / Female / Humans / Ischemic Attack, Transient / Male / Middle Aged / Retrospective Studies / Risk Factors / Sensitivity and Specificity / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.117.014576
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28536173; ● Summary page in Scopus @ Elsevier: 2-s2.0-85019546161

(DOI: 10.1161/STROKEAHA.117.014576, PubMed: 28536173, Elsevier: Scopus) Izumi Yamaguchi, Junichiro Satomi, Nobuaki Yamamoto, Shotaroh Yoshioka, Yoshiteru Tada, Kenji Yagi, Yasuhisa Kanematsu and Shinji Nagahiro :
Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review,
NMC Case Report Journal, Vol.4, 5-9, 2017.

(要約): POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare paraneoplastic syndrome elicited by plasma cell dyscrasia. Its clinical manifestations are multiple and stroke is not a recognized feature. A 44-year-old woman with a 3-month history of bilateral lower extremity sensorimotor disturbance was admitted to our hospital. Examinations revealed polyneuropathy, organomegaly, hypothyroidism, monoclonal gammopathy, pelvic plasmacytoma, and elevated serum vascular endothelial growth factor (VEGF) levels. A diagnosis of POEMS was made. Her condition was improved by radiation therapy of her pelvic plasmacytoma and she continued to be seen on an outpatient basis. Five years after her first admission she was re-admitted with sudden-onset right hemiparesis. A brain computed tomography (CT) scan revealed a left intracranial hemorrhage and magnetic resonance (MR) angiography and cerebral angiography showed occlusion of the proximal portion of the bilateral middle cerebral artery and narrowing of the bilateral internal carotid artery at the terminal portion; moyamoya vessels were seen. This is the first report of a patient whose intracranial hemorrhage was attributable to quasi-moyamoya disease associated with POEMS syndrome. We suggest that the POEMS syndrome be ruled out in the differential diagnosis of patients presenting with atypical stroke, multivessel stenotic lesions (moyamoya vessels), and polyneuropathy.
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmccrj.cr.2016-0106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28664017; ● Search Scopus @ Elsevier (PMID): 28664017; ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2016-0106

(DOI: 10.2176/nmccrj.cr.2016-0106, PubMed: 28664017) Akemi Hioka, Yoshifumi Mizobuchi, Yoshiteru Tada, Kyoko Nishi, Yasuhiko Shirayama, Shinsuke Katoh, N Akazawa, Ryuji Kaji, Y Ojima and Shinji Nagahiro :
Usefulness of a novel higher brain dysfunction screening test for evaluating higher brain function in healthy persons.,
The Journal of Medical Investigation : JMI, Vol.64, No.3.4, 280-285, 2017.

(要約): To accurately and rapidly screen for higher brain dysfunction, we developed a screening test named the "higher brain dysfunction screening test" (HIBRID-ST). Previous studies have reported a decrease in higher brain function with age. However, whether HIBRID-ST can detect a decrease in higher brain function in healthy persons remains unclear. We aimed to assess the usefulness of HIBRID-ST for evaluating higher brain function in healthy persons. We recruited 60 persons without physiological abnormalities and divided them into six equal groups based on their age (20s-70s). HIBRID-ST addresses orientation, short-term memory, word recall, situational awareness, visual short-term memory, and graphic replication and includes the Trail Making and Kana-hiroi tests. There was a significant negative correlation between the participants' age and their total HIBRID-ST score (ϱ = -0.68, p < 0.01). The total HIBRID-ST score of participants in their 70s was significantly lower than that of participants in their 20s-60s; the total HIBRID-ST score of participants in their 60s was significantly lower than that of participants in their 20s-50s. Our findings show that HIBRID-ST accurately detects an age-related decline in higher brain function. Further studies are needed to examine the usefulness of HIBRID-ST in patients with higher brain dysfunction. J. Med. Invest. 64: 280-285, August, 2017.
(キーワード): Adult / Aged / 加齢 (aging) / 脳 (brain) / Cross-Sectional Studies / 女性 (female) / Humans / 男性 (male) / Middle Aged
(徳島大学機関リポジトリ): ● Metadata: 111133
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.64.280
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28954996; ● Search Scopus @ Elsevier (PMID): 28954996; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.64.280

(徳島大学機関リポジトリ: 111133, DOI: 10.2152/jmi.64.280, PubMed: 28954996) 蔭山彩人, 兼松康久, 山口泉, 山本伸昭, 木内智也, 多田恵曜, 西京子, 里見淳一郎, 永廣信治 :
徳島大学病院脳卒中センターにおける院内発症脳卒中の検討,
四国医学雑誌, Vol.72, No.5-6, 195-198, 2016年.

(要約): We assessed the current status of patients with acute in-hospital stroke. 63 patients with acute in-hospital stroke were enrolled. The most prevalent subtype of stroke was embolism(n＝24). The main cause of hospitalization were malignant neoplasms in15. Only 5 patients were treated with rt-PA, 8 patients received endovascular interventions. In-hospital stroke is a sever complication of in-patients and is associated with an unfavorable prognosis, but endovascular interventions offer safe and feasible therapeutic treatment options.
(キーワード): in-hospital ischemic stroke / rt-PA / stroke care services / endovascular interventions
(徳島大学機関リポジトリ): ● Metadata: 110402
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762395251200

(徳島大学機関リポジトリ: 110402, CiNii: 1050845762395251200) Yoko Yamamoto, Toshiyuki Okazaki, Keishi Yoda, Yoshiteru Tada and Shinji Nagahiro :
Successful emergency carotid endarterectomy after thrombolysis with intravenous recombinant tissue-type plasminogen activator,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 300-304, 2016.

(要約): Acute internal carotid artery (ICA) occlusion may result in severe disability or death. Revascularization by carotid artery stenting after treatment with intravenous (iv) recombinant tissue-type plasminogen activator (rt-PA) has been documented. However, there are few reports on emergency carotid endarterectomy (CEA) within 24 hours after the iv administration of rt-PA. We treated a 58-year-old man with right ICA occlusion with iv rt-PA. Although partial recanalization of the ICA was obtained, severe stenosis at the origin of the ICA persisted and he developed fluctuating neurological deficits. To prevent progressive stroke he underwent CEA 10.5 hours after rt-PA treatment. Thereafter his blood pressure was strictly controlled under sedation. During and after CEA there were no hemorrhagic complications. Our findings suggest that emergency CEA may be an option to address symptomatic severe residual ICA stenosis even after iv rt-PA therapy delivered in the acute stage. J. Med. Invest. 63: 300-304, August, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111198
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644576; ● Search Scopus @ Elsevier (PMID): 27644576; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.63.300

(徳島大学機関リポジトリ: 111198, DOI: 10.2152/jmi.63.300, PubMed: 27644576) Masaaki Korai, 北里慶子, Yoshiteru Tada, Takeshi Miyamoto, Kenji Shimada, Nobuhisa Matsushita, Yasuhisa Kanematsu, Junichiro Satomi, 橋本友紀 and Shinji Nagahiro :
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats,
Journal of Neuroinflammation, Vol.13, No.1, 165, 2016.

(要約): Hyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall. However, the role of HHcy in the growth and rupture of cerebral aneurysms remains unclear. Thirteen-week-old female Sprague-Dawley rats were subject to bilateral ovariectomy and ligation of the right common carotid artery and fed an 8 % high-salt diet to induce cerebral aneurysms. Two weeks later, they underwent ligation of the bilateral posterior renal arteries. They were divided into two groups and methionine (MET) was or was not added to their drinking water. In another set of experiments, the role of folic acid (FA) against cerebral aneurysms was assessed. During a 12-week observation period, subarachnoid hemorrhage due to aneurysm rupture was observed at the anterior communicating artery (AcomA) or the posterior half of the circle of Willis. HHcy induced by excessive MET intake significantly increased the incidence of ruptured aneurysms at 6-8 weeks. At the AcomA of rats treated with MET, we observed the promotion of aneurysmal growth and infiltration by M1 macrophages. Furthermore, the mRNA level of MMP-9, the ratio of MMP-9 to the tissue inhibitor of metalloproteinase-2, and the level of interleukin-6 were higher in these rats. Treatment with FA abolished the effect of MET, suggesting that the inflammatory response and vascular degradation at the AcomA is attributable to HHcy due to excessive MET intake. We first demonstrate that in hypertensive ovariectomized rats, HHcy induced by excessive MET intake may be associated with the propensity of the aneurysm wall to rupture.
(徳島大学機関リポジトリ): ● Metadata: 110031
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12974-016-0634-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27349749; ● Search Scopus @ Elsevier (PMID): 27349749; ● Search Scopus @ Elsevier (DOI): 10.1186/s12974-016-0634-3

(徳島大学機関リポジトリ: 110031, DOI: 10.1186/s12974-016-0634-3, PubMed: 27349749) Takeshi Miyamoto, DK Kung, KT Kitazato, Kenji Yagi, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Yoshitaka Kurashiki, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi, T Hashimoto and Shinji Nagahiro :
Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model,
Journal of Cerebral Blood Flow and Metabolism, Vol.37, No.8, 2795-2805, 2016.

(要約): The pathogenesis of subarachnoid hemorrhage remains unclear. No models of cerebral aneurysms elicited solely by surgical procedures and diet have been established. Elsewhere we reported that only few rats in our original rat aneurysm model manifested rupture at the anterior and posterior Willis circle and that many harbored unruptured aneurysms at the anterior cerebral artery-olfactory artery bifurcation. This suggests that rupture was site-specific. To test our hypothesis that a site-specific response to hemodynamic changes is associated with aneurysmal rupture, we modified our original aneurysm model by altering the hemodynamics. During 90-day observation, the incidence of ruptured aneurysms at the anterior and posterior Willis circle was significantly increased and the high incidence of unruptured aneurysms at the anterior cerebral artery-olfactory artery persisted. This phenomenon was associated with an increase in the blood flow volume. Notably, the level of matrix metalloproteinase-9 associated with interleukin-1β was augmented by the increase in the blood flow volume, suggesting that these molecules exacerbated the vulnerability of the aneurysmal wall. The current study first demonstrates that a site-specific increase in interleukin-1β and matrix metalloproteinase-9 elicited by hemodynamic changes is associated with rupture. Our novel rat model of rupture may help to develop pharmaceutical approaches to prevent rupture.
(徳島大学機関リポジトリ): ● Metadata: 110032
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0271678X16675369
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27798272; ● Search Scopus @ Elsevier (PMID): 27798272; ● Search Scopus @ Elsevier (DOI): 10.1177/0271678X16675369

(徳島大学機関リポジトリ: 110032, DOI: 10.1177/0271678X16675369, PubMed: 27798272) Nobuaki Yamamoto, Junichiro Satomi, Yamamoto Yuki, Takahiro Furukawa, Yoshiteru Tada, Masafumi Harada, Shinji Nagahiro and Ryuji Kaji :
The susceptibility vessel sign containing two compositions on 3-tesla T2*-weighted image and single corticosubcortical infarct on diffusion-weighted image are associated with cardioembolic stroke,
Journal of the Neurological Sciences, Vol.359, No.1-2, 141-145, 2015.

(要約): Although accurate diagnosis of the ischemic stroke subtype is one of the most important factors for selection of therapeutic approach, it is sometimes difficult at the time of admission. We previously reported that susceptibility vessel sign (SVS) with two layers (termed two-layered SVS) on 3-tesla-T2*-weighted image (T2*-WI) might be useful to predict cardioembolic stroke in patients with cerebral major vessel occlusion. We studied about biomarkers on magnetic resonance imaging (MRI), including two-layered SVS for diagnosing cardioembolic stroke. We included 132 ischemic stroke patients within 24h from onset who suffered internal carotid artery or middle cerebral artery occlusion due to cardioembolic stroke (group CE) or large artery atherosclerosis (group LAA). We studied about biomarkers on MRI such as two-layered SVS and abnormal finding patterns of diffusion-weighted image (DWI) for diagnosis of cardioembolic stroke in addition to laboratory data, physiological examination, and clinical findings. In this study, 132 patients (72 men and 60 women, age 74.5 ± 12.1 years) were included. Of these, 63 (47.7%) were cardioembolic stroke. In univariate analysis, frequency of comorbid atrial fibrillation, presence of two-layered SVS on T2*-WI and that of single corticosubcortical infarct on DWI, intima-media thickness were significantly higher in group CE. In multivariate analysis, the presence of two-layered SVS and single corticosubcortical infarct were associated with cardioembolic stroke (odds ratio, two-layered SVS, 30.08, p<0.001; single corticosubcortical infarct, 15.78, p<0.001). Biomarkers associated with cardioembolic stroke may be two-layered SVS on T2*-WI and single corticosubcortical infarct on DWI.
(キーワード): 3-T MRI / T2*-weighted image / SVS / Two-layered SVS / Diffusion-weighted image / Stroke subtype
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2015.10.033
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26671103; ● Summary page in Scopus @ Elsevier: 2-s2.0-84949635529

(DOI: 10.1016/j.jns.2015.10.033, PubMed: 26671103, Elsevier: Scopus) Kenji Shimada, Hjime Furukawa, Kousuke Wada, Masaaki Kohrai, Yuan Wei, Yoshiteru Tada, Atsushi Kuwahara, Fumiaki Shikata, Keiko T. Kitazato, Shinji Nagahiro, Michael T. Lawton and Tomoki Hashimoto :
Protective role of peroxisome proliferator-activated receptor- in the development of intracranial aneurysm rupture,
Stroke, Vol.46, No.6, 1664-1672, 2015.

(要約): Inflammation is emerging as a key component of the pathophysiology of intracranial aneurysms. Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear hormone receptor of which activation modulates various aspects of inflammation. Using a mouse model of intracranial aneurysm, we examined the potential roles of PPARγ in the development of rupture of intracranial aneurysm. A PPARγ agonist, pioglitazone, significantly reduced the incidence of ruptured aneurysms and the rupture rate without affecting the total incidence aneurysm (unruptured aneurysms and ruptured aneurysms). PPARγ antagonist (GW9662) abolished the protective effect of pioglitazone. The protective effect of pioglitazone was absent in mice lacking macrophage PPARγ. Pioglitazone treatment reduced the mRNA levels of inflammatory cytokines (monocyte chemoattractant factor-1, interleukin-1, and interleukin-6) that are primarily produced by macrophages in the cerebral arteries. Pioglitazone treatment reduced the infiltration of M1 macrophage into the cerebral arteries and the macrophage M1/M2 ratio. Depletion of macrophages significantly reduced the rupture rate. Our data showed that the activation of macrophage PPARγ protects against the development of aneurysmal rupture. PPARγ in inflammatory cells may be a potential therapeutic target for the prevention of aneurysmal rupture.
(キーワード): Aneurysm, Ruptured / Anilides / Animals / Cerebral Arteries / 細胞質分裂 (cytokinesis) / Hypoglycemic Agents / Intracranial Aneurysm / Macrophages / Mice / ノックアウトマウス (knockout mice) / PPAR gamma / Thiazolidinediones
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.114.007722
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25931465; ● Summary page in Scopus @ Elsevier: 2-s2.0-84942924464

(DOI: 10.1161/STROKEAHA.114.007722, PubMed: 25931465, Elsevier: Scopus) Yoshiteru Tada, Kenji Yagi, Masaaki Uno, Nobuhisa Matsushita, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Shimada, Kyoko Nishi, Motohiro Hirasawa, Junichiro Satomi, KT Kitazato, Teruyoshi Kageji, E Matsumura and Shinji Nagahiro :
Improvement of plasma biomarkers after switching stroke patients from other angiotensin II type I receptor blockers to olmesartan,
Journal of Stroke & Cerebrovascular Diseases, Vol.24, 1487-1492, 2015.

(要約): Managing hypertension is crucial for preventing stroke recurrence. Some stroke patients experience resistant hypertension. In our experimental stroke model, olmesartan increased the expression of angiotensin (Ang) II converting enzyme-2. We hypothesized that switching to olmesartan affects biomarkers and the blood pressure (BP) in stroke patients whose BP is insufficiently controlled by standard doses of Ang II type I receptor blockers (ARBs) other than olmesartan. We recruited 25 patients to study our hypothesis. All had a history of stroke or silent cerebral infarction. We switched them to olmesartan (10-40 mg per day) for 12 weeks and determined their plasma level of Ang-(1-7), peroxiredoxin, oxidized low-density lipoprotein (oxLDL)/β-2-glycoprotein I (β2GPI) complex, adiponectin, high mobility group box 1 (HMGB1), and tumor necrosis factor-α (TNFα) and recorded their BP before and after olmesartan treatment. After switching the patients to olmesartan, their plasma level of Ang-(1-7) as a vasoprotective indicator and adiponectin regulating metabolic syndrome was increased, and peroxiredoxin and the oxLDL/β2GPI complex indicating its antioxidative stress and its proatherogenicity were lower than their baseline. This suggests that olmesartan may be more effective than other ARBs to improve these conditions. Neither HMGB1 nor TNFα reflecting an inflammatory response was affected, suggesting that the anti-inflammatory effects of olmesartan are similar to those of other ARBs. The recommended BP (<140/90) was obtained in 10 of the 25 patients after switching to olmesartan. No adverse events occurred. Switching from other ARBs to olmesartan may be a promising therapeutic option in patients with resistant hypertension.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2015.03.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25891757; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930820228

(DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.015, PubMed: 25891757, Elsevier: Scopus) Kenji Shimada, Hajime Furukawa, Kosuke Wada, Yuan Wei, Yoshiteru Tada, Atsushi Kuwabara, Fumiaki Shikata, Yasuhisa Kanematsu, Michael T. Lawton, Keiko T. Kitazato, Shinji Nagahiro and Tomoki Hashimoto :
Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice,
Journal of Cerebral Blood Flow and Metabolism, Vol.35, No.7, 1163-1168, 2015.

(要約): Angiotensin-(1-7) (Ang-(1-7)) can regulate vascular inflammation and remodeling, which are processes that have important roles in the pathophysiology of intracranial aneurysms. In this study, we assessed the effects of Ang-(1-7) in the development of intracranial aneurysm rupture using a mouse model of intracranial aneurysms in which aneurysmal rupture (i.e., aneurysmal subarachnoid hemorrhage) occurs spontaneously and causes neurologic symptoms. Treatment with Ang-(1-7) (0.5 mg/kg/day), Mas receptor antagonist (A779 0.5 mg/kg/day or 2.5 mg/kg/day), or angiotensin II type 2 receptor (AT2R) antagonist (PD 123319, 10 mg/kg/day) was started 6 days after aneurysm induction and continued for 2 weeks. Angiotensin-(1-7) significantly reduced the rupture rate of intracranial aneurysms without affecting the overall incidence of aneurysms. The protective effect of Ang-(1-7) was blocked by the AT2R antagonist, but not by the Mas receptor antagonist. In AT2R knockout mice, the protective effect of Ang-(1-7) was absent. While AT2R mRNA was abundantly expressed in the cerebral arteries and aneurysms, Mas receptor mRNA expression was very scarce in these tissues. Angiotensin-(1-7) reduced the expression of tumor necrosis factor-α and interleukin-1β in cerebral arteries. These findings indicate that Ang-(1-7) can protect against the development of aneurysmal rupture in an AT2R-dependent manner.
(キーワード): Aneurysm, Ruptured / Angiotensin I / Angiotensin II / Angiotensin II Type 2 Receptor Blockers / Animals / 脳 (brain) / Cerebral Arteries / 細胞質分裂 (cytokinesis) / Imidazoles / Male / Mice / Mice, Inbred C57BL / ノックアウトマウス (knockout mice) / Peptide Fragments / Pyridines / RNA, Messenger / Receptor, Angiotensin, Type 2 / Subarachnoid Hemorrhage
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/jcbfm.2015.30
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25757758; ● Summary page in Scopus @ Elsevier: 2-s2.0-84934443499

(DOI: 10.1038/jcbfm.2015.30, PubMed: 25757758, Elsevier: Scopus) Norio Nakajima, Shinji Nagahiro, Junichiro Satomi, Yoshiteru Tada, Kohhei Nakajima, Shu Sogabe, Mami Hanaoka, Shunji Matsubara, Masaaki Uno and Koichi Satoh :
Prevention of retrograde blood flow into large or giant internal carotid artery aneurysms by endovascular coil embolization with high-flow bypass: surgical technique and long-term results,
World Neurosurgery, Vol.83, No.6, 1127-1134, 2015.

(要約): Recanalization has been reported in large or giant aneurysms of the internal carotid artery (ICA) addressed by high-flow bypass and endovascular treatment. Aneurysmal recanalization may be attributable to retrograde blood flow into the aneurysm through the ICA branches, such as the ophthalmic artery or the meningohypophyseal trunk, or through the surgically created bypass. We modified the endovascular treatment of aneurysms to prevent retrograde flow and evaluated the long-term efficacy of our method. We used a hybrid operative/endovascular technique to treat 5 patients with large or giant aneurysms arising from the C2-C4 segment of the ICA who presented with visual symptoms due to the mass effect of the aneurysm. To prevent retrograde flow into the aneurysm our modified endovascular treatment involves coil embolization of the aneurysmal orifice and the ICA, including the origin of the ophthalmic artery and meningohypophyseal trunk, and placement of a high-flow bypass using a radial artery graft. During the 5- to 12-year follow-up period, 4 aneurysms disappeared, and the other decreased in size. There were no subarachnoid hemorrhages. All bypass grafts remained patent. Visual preservation was achieved in 2 patients; 1 patient manifested visual improvement. Although 2 patients experienced transient neurological deficits we encountered no permanent complications in this series. The final modified Rankin scale of the 5 patients was 0 or 1. Prevention of retrograde flow into the aneurysm by coil embolization with high-flow bypass is a safe and effective method. It prevents the recanalization of large or giant ICA aneurysms.
(キーワード): Adult / Aged / Angiography / Blood Flow Velocity / Carotid Artery, Internal, Dissection / Cerebrovascular Circulation / Embolization, Therapeutic / Endovascular Procedures / Female / Follow-Up Studies / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2015.01.037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25681599; ● Summary page in Scopus @ Elsevier: 2-s2.0-84930929071

(DOI: 10.1016/j.wneu.2015.01.037, PubMed: 25681599, Elsevier: Scopus) Nobuaki Yamamoto, Junichiro Satomi, Yoshiteru Tada, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji :
The two-1 layered susceptibility vessel sign on 3-tesla T2*-weighted imaging is a predictive biomarker of stroke subtype,
Stroke, Vol.46, No.1, 269-271, 2014.

(要約): A susceptibility vessel sign (SVS) on 1.5-tesla (T)-T2*-weighted images may predict cardioembolism. It has also been detected in patients with large artery atherosclerosis. In patients with major vessel occlusion, the SVS was comprised 2 layers on 3T-T2*-weighted images. We assessed the efficacy of 2-layered SVS on 3T-T2*-weighted imaging scans for predicting cardioembolism. Our study included 132 patients who had ischemic stroke within the preceding 24 hours and presented with internal carotid artery or middle cerebral artery occlusion because of cardioembolism or large artery atherosclerosis. We compared 2-layered SVS and SVS on 3T-T2*-weighted imaging scans for their sensitivity, specificity, and diagnostic odds ratio for predicting cardioembolism. We enrolled 132 patients (72 men; mean age, 74.5 years); of these, 63 (47.7%) were presented with cardioembolism. Although the sensitivity of SVS and 2-layered SVS for cardioembolism and large artery atherosclerosis was not statistically different (74.6% and 58.0%, respectively), the sensitivity of 2-layered SVS was significantly higher in patients with cardioembolism (42.9%) than those with large artery atherosclerosis (2.9%; P<0.001). The specificity and diagnostic odds ratio for 2-layered SVS for cardioembolism were 97.1% and 25.1; for SVS they were 42.0% and 2.1, respectively. The specificity of 2-layered SVS for cardioembolism was high. It may be useful for predicting cardioembolism and for the management of patients with acute ischemic stroke.
(キーワード): imaging biomarker / 3-tesla magnetic resonance imaging / T2*-weighted imaging / susceptibility vessel sign / two-layered susceptibility vessel sign
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.114.007227
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25477219; ● Summary page in Scopus @ Elsevier: 2-s2.0-84920283485

(DOI: 10.1161/STROKEAHA.114.007227, PubMed: 25477219, Elsevier: Scopus) Yoshiteru Tada, Hiroshi Makino, Hajime Furukawa, Kenji Shimada, Kosuke Wada, EI Liang, Shoko Murakami, Mari Kudo, DK Kung, KT Kitazato, Shinji Nagahiro, MT Lawton and Tomoki Hashimoto :
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice,
Neurosurgery, Vol.75, No.6, 690-695, 2014.

(要約): Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. Intracranial aneurysms were induced in mice by combining a single injection of elastase into the cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The mice were treated with estrogen (17β-estradiol), an ERα agonist (propyl pyrazole triol), and an ERβ agonist (diarylpropionitrile) with and without a nitric oxide synthase inhibitor. The ovariectomized female mice had a significantly higher incidence of aneurysms than the male mice, which was consistent with findings in previous epidemiological studies. In ovariectomized female mice, an ERβ agonist, but not an ERα agonist or 17β-estradiol, significantly reduced the incidence of aneurysms. The protective effect of the ERβ agonist was absent in the ovariectomized ERβ knockout mice. The protective effect of the ERβ agonist was negated by treatment with a nitric oxide synthase inhibitor. The effects of sex, menopause, and estrogen treatment observed in this animal study were consistent with previous epidemiological findings. Stimulation of estrogen receptor-β was protective against the formation of intracranial aneurysms in ovariectomized female mice.
(キーワード): Animals / Disease Models, Animal / Estradiol / Estrogen Receptor alpha / Estrogen Receptor beta / Estrogens / Female / Intracranial Aneurysm / Male / Mice / Mice, Knockout / Nitriles / Ovariectomy / Propionates / Pyrazoles / Sex Characteristics
(出版サイトへのリンク): ● Publication site (DOI): 10.1227/NEU.0000000000000528
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25181430; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925871499

(DOI: 10.1227/NEU.0000000000000528, PubMed: 25181430, Elsevier: Scopus) 多田恵曜, 平澤元浩, 牟礼英生, 里見淳一郎, 山本伸昭, 阿部考志, 永廣信治 :
T2強調画像で脊髄内に高信号を呈する病変圧迫骨折を伴い，両下肢の筋力低下で発症した80歳女性,
脳神経外科速報, Vol.24, No.11, 1208-1211, 2014年. Yoshiteru Tada, Junichiro Satomi, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Nobuhisa Matsushita, Takashi Abe, Masafumi Harada and Shinji Nagahiro :
Post-ischemic hyperperfusion after clipping of a reptured internal carotid-posterior communicating artery aneurysm under suction decomperession,
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, Vol.1, No.3, 62-65, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.inat.2014.07.005
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84940288718

(DOI: 10.1016/j.inat.2014.07.005, Elsevier: Scopus) Yoshiteru Tada, K Wada, Kenji Shimada, H Makino, EI Liang, S Murakami, M Kudo, F Shikata, RAP Silva, KT Kitazato, DM Hasan, Yasuhisa Kanematsu, Shinji Nagahiro and T Hashimoto :
Estrogen protects against intracranial aneurysm rupture in ovariectomized mice,
Hypertension, Vol.63, 1339-1344, 2014.

(要約): Clinical observations suggest that postmenopausal women have a higher incidence of aneurysmal rupture than premenopausal women. We hypothesize that a relative deficiency in estrogen may increase the risks of aneurysmal growth and subarachnoid hemorrhage in postmenopausal women. We assessed the effects of estrogen and selective estrogen receptor subtype agonists on the development of aneurysmal rupture in ovariectomized female mice. We used an intracranial aneurysm mouse model that recapitulates the key features of human intracranial aneurysms, including spontaneous rupture. Ten- to 12-week-old ovariectomized female mice received treatment with estrogen, nonselective estrogen receptor antagonist, estrogen receptor-α agonist, or estrogen receptor-β agonist starting 6 days after aneurysm induction so that the treatments affected the development of aneurysmal rupture without affecting aneurysmal formation. Estrogen significantly reduced the incidence of ruptured aneurysms and rupture rates in ovariectomized mice. Nonselective estrogen receptor antagonist abolished the protective effect of estrogen. Although estrogen receptor-α agonist did not affect the incidence of ruptured aneurysms or rupture rates, estrogen receptor-β agonist prevented aneurysmal rupture without affecting the formation of aneurysms. The protective role of estrogen receptor-β agonist was abolished by the inhibition of nitric oxide synthase. We showed that estrogen prevented aneurysmal rupture in ovariectomized female mice. The protective effect of estrogen seemed to occur through the activation of estrogen receptor-β, a predominant subtype of estrogen receptor in human intracranial aneurysms and cerebral arteries.
(キーワード): Aged / Aneurysm, Ruptured / Animals / Disease Models, Animal / Enzyme Inhibitors / Estradiol / Estrogen Antagonists / Estrogen Receptor alpha / Estrogen Receptor beta / Estrogens / Female / Humans / Intracranial Aneurysm / Mice / Mice, Inbred C57BL / Middle Aged / NG-Nitroarginine Methyl Ester / Nitric Oxide / Nitric Oxide Synthase / Nitriles / Ovariectomy / Pyrazoles / Subarachnoid Hemorrhage
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.114.03300
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24732889; ● Search Scopus @ Elsevier (PMID): 24732889; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.114.03300

(DOI: 10.1161/HYPERTENSIONAHA.114.03300, PubMed: 24732889) Yoshiteru Tada, Junichiro Satomi, Takashi Abe, Kazuyuki Kuwayama, Shu Sogabe, Koji Fujita, Nobuaki Yamamoto, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro :
Intra-arterial signal on arterial spin labeling perfusion MRI to identify the presence of acute middle cerebral artery occlusion,
Cerebrovascular Diseases, Vol.38, No.3, 191-196, 2014.

(要約): The susceptibility vessel sign on gradient echo-type-T2*-weighted imaging is a well-known marker of arterial occlusion. Stagnant flow in front of the middle cerebral artery (MCA) occlusion sites may contribute to the intra-arterial, high-intensity signal on arterial spin labeling magnetic resonance imaging (MRI), making it another potential marker of MCA occlusion. We compared the intra-arterial, high-intensity signal and susceptibility vessel sign in patients with symptomatic MCA occlusion and patients without major vessel occlusion. We identified transient ischemic attack or ischemic stroke patients with (1) 3-T MRI performed within 24 h after clinical onset including arterial spin labeling, T2*-weighted imaging, and magnetic resonance angiography (MRA) and (2) either having MCA occlusion (n = 34 patients) or without major vessel occlusion (n = 24 patients). The intra-arterial, high-intensity signal was defined as an enlarged circular or linear bright hyperintensity within the artery. The susceptibility vessel sign was defined as an enlarged spot of hypointensity within the MCA, in which the diameter of the hypointense signal within the vessel exceeded the contralateral vessel diameter. The presence or absence of the intra-arterial, high-intensity signal and susceptibility vessel sign were assessed, along with their inter-rater agreement and consistency with the presence of MCA occlusion on MRA. The intra-arterial, high-intensity signal was detectable in 30 patients (52%), and susceptibility vessel sign was observed in 17 patients (29%). The sensitivity of the intra-arterial high-intensity signal was significantly higher than that of the susceptibility vessel sign (88% vs. 50%; p < 0.05). The accuracy of the intra-arterial high-intensity signal was also higher than that of the susceptibility vessel sign (93% vs. 71%; p < 0.05). The intra-arterial high-intensity signal was situated in the proximal regions of the susceptibility vessel sign on T2*WI within the MCA. Neither the intra-arterial high-intensity signal nor the susceptibility vessel sign was observed in patients without major vessel occlusion. Inter-rater agreement was good for intra-arterial high-intensity signal detection (κ = 0.73) and moderate for susceptibility vessel sign detection (κ = 0.47). The presence or absence of the intra-arterial high-intensity signal was highly consistent with that of MCA occlusion on MRA (κ = 0.74). The intra-arterial high-intensity signal on arterial spin labeling appears to be useful to identify the presence of acute MCA occlusion and may be associated with stagnant flow in front of occlusion sites. The intra-arterial high-intensity signal may also be used to identify the occlusion site.
(キーワード): Aged / Aged, 80 and over / Cerebral Angiography / Female / Humans / Infarction, Middle Cerebral Artery / Ischemic Attack, Transient / Magnetic Resonance Angiography / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Middle Cerebral Artery / Sensitivity and Specificity / Stroke
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000365653
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25300901; ● Summary page in Scopus @ Elsevier: 2-s2.0-84912121647

(DOI: 10.1159/000365653, PubMed: 25300901, Elsevier: Scopus) Yoshiteru Tada, Wada Kosuke, Kenji Shimada, Makino Hiroshi, EI Liang, Murakami Shoko, Kudo Mari, KT Kitazato, Shinji Nagahiro and Hashimoto Tomoki :
Roles of hypertension in the rupture of intracranial aneurysms,
Stroke, Vol.45, No.2, 579-586, 2014.

(要約): Systemic hypertension has long been considered a risk factor of aneurysmal rupture. However, a causal link between systemic hypertension and the development of aneurysmal rupture has not been established. In this study, using a mouse model of intracranial aneurysm rupture, we examined the roles of systemic hypertension in the development of aneurysmal rupture. Aneurysms were induced by a combination of deoxycorticosterone acetate (DOCA)-salt and a single injection of elastase into the cerebrospinal fluid in mice. Antihypertensive treatment was started 6 days after aneurysm induction. Aneurysmal rupture was detected by neurological symptoms and confirmed by the presence of intracranial aneurysm with subarachnoid hemorrhage. Hydralazine (direct vasodilator) or discontinuation of DOCA-salt treatment was used to assess the roles of systemic hypertension. Captopril (angiotensin-converting enzyme inhibitor) or losartan (angiotensin II type 1 receptor antagonist) was used to assess the roles of the local renin-angiotensin system in the vascular wall. Normalization of blood pressure by hydralazine significantly reduced the incidence of ruptured aneurysms and the rupture rate. There was a dose-dependent relationship between reduction of blood pressure and prevention of aneurysmal rupture. Captopril and losartan were able to reduce rupture rate without affecting systemic hypertension induced by DOCA-salt treatment. Normalization of blood pressure after aneurysm formation prevented aneurysmal rupture in mice. In addition, we found that the inhibition of the local renin-angiotensin system independent from the reduction of blood pressure can prevent aneurysmal rupture.
(キーワード): Aneurysm, Ruptured / Animals / Antihypertensive Agents / Blood Pressure / Captopril / Desoxycorticosterone Acetate / Dose-Response Relationship, Drug / Hydralazine / Hypertension / Intracranial Aneurysm / Losartan / Male / Mice / Mice, Inbred C57BL / Pancreatic Elastase / Renin-Angiotensin System / Risk Factors / Subarachnoid Hemorrhage / Survival Analysis / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.113.003072
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24370755; ● Summary page in Scopus @ Elsevier: 2-s2.0-84893815565

(DOI: 10.1161/STROKEAHA.113.003072, PubMed: 24370755, Elsevier: Scopus) 里見淳一郎, 多田恵曜, 八木謙次, 松下展久, 山本伸昭, 兼松康久, 永廣信治 :
80歳以上の破裂脳動脈瘤の治療成績,
脳卒中の外科, Vol.42, No.1, 42-46, 2014年.

(要約): While the number of elderly patients who presented with aneurysmal subarachnoid hemorrhage (SAH) has been increasing, its optimal management in that population remains controversial. Therefore, we retrospectively reviewed the treatment outcomes in 49 consecutive patients aged between 80 and 94 years who presented with SAH. The neurological World Federation of Neurological Surgeons (WFNS) grade at the time of admission was Grade I in 7, Grade II in 11, Grade III in 8, Grade IV in 13, and Grade V in 10 patients. Of the 49 patients, 28 underwent coil embolization, and 7 (25%) had a favorable outcome (mRS: 0-2) at discharge, while in 21 (75%) the outcome was poor (mRS: 3-6). Six patients underwent clipping; the outcome was favorable in one patient (17%) and poor in 5 (83%). Of 15 patients under conservative therapy none had a favorable outcome. A low WFNS grade (I-II) was significantly associated with a favorable outcome (p<0.05). Although the treatment outcome in elderly patients with SAH was poor, radical treatment of ruptured aneurysms should be considered if their WFNS grade is low.
(キーワード): ruptured aneurysm / elderly patients / outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2335/scs.42.42
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204673719808; ● Search Scopus @ Elsevier (DOI): 10.2335/scs.42.42

(DOI: 10.2335/scs.42.42, CiNii: 1390001204673719808) 多田恵曜, 永廣信治 :
くも膜下出血の病態,
日本臨牀, Vol.72, No.7, 449-452, 2014年. 多田恵曜, 北里慶子, 永廣信治 :
脳動脈瘤におけるNa+蓄積とRASの影響,
Angiotensin Research, Vol.10, No.2, 84-92, 2013年. 里見淳一郎, 多田恵曜, 永廣信治 :
Radiculopathy で発症した頚椎硬膜外病変の1例,
脳神経外科ジャーナル, Vol.22, No.1, 69-71, 2013年.

(出版サイトへのリンク): ● Publication site (DOI): 10.7887/jcns.22.69
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679382311936; ● Search Scopus @ Elsevier (DOI): 10.7887/jcns.22.69

(DOI: 10.7887/jcns.22.69, CiNii: 1390282679382311936) 羽星辰哉, 八木謙次, 多田恵曜, 松下展久, 兼松康久, 坂東美佳, 上田由佳, 山田博胤, 里見淳一郎, 西京子, 佐田政隆, 永廣信治 :
くも膜下出血に続発した重症のNeurogenic stress cardiomyopathyの検討,
四国医学雑誌, Vol.68, No.5, 6, 233-238, 2012年.

(キーワード): neurogenic stress cardiomyopathy / subarachnoid hemorrhage / sympathetic nerve
(徳島大学機関リポジトリ): ● Metadata: 110362
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762395239424

(徳島大学機関リポジトリ: 110362, CiNii: 1050845762395239424) Tomoya Kinouchi, Keiko T. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats,
Stroke, Vol.43, No.2, 478-483, 2012.

(要約): The role of the phosphorylated signal transducer and activator of transcription-3 (p-STAT3) after cerebral ischemia by the peroxisome proliferator-activated receptor (PPAR) agonist pioglitazone (PGZ) remains controversial. Whether the increase in p-STAT3 by estrogen is mediated by the estrogen receptor is also obscure. We examined the role of p-STAT3, PPAR, and estrogen receptor against ischemic brain damage after PGZ treatment. Female Wistar rats subjected or not subjected to bilateral oophorectomy were injected with 1.0 or 2.5 mg/kg PGZ 2 days, 1 day, and 1 hour before 90-minute middle cerebral artery occlusion-reperfusion and compared with vehicle-control rats. The cortical infarct size was larger in ovariectomized than in nonovarietomized rats; it was reduced by PGZ treatment. Inversely with the reduction of the infarct size, PPAR, and p-STAT3 but not estrogen receptor in the peri-infarct area were increased in PGZ-treated compared with vehicle-control rats. The increase in PPAR and p-STAT3 was associated with the transactivation of antiapoptotic and survival genes and the reduction of caspase-3 in this area. Inhibitors of PPAR or STAT3 abolished the PGZ-induced neuroprotection and the increase in p-STAT3. More importantly, p-STAT3 increased by PGZ was bound to PPAR and the complex translocated to the nucleus to dock to the response element through p-STAT3. Our findings suggest that the activation in the peri-infarct region of p-STAT3 and PPAR by PGZ is essential for neuroprotection after ischemia and that PGZ may be of benefit even in postmenopausal stroke patients.
(キーワード): Animals / Apoptosis / Basal Ganglia / Brain / Brain Ischemia / Caspase 3 / Cell Nucleus / Cerebral Infarction / DNA / Estrogen Receptor alpha / Female / Neuroprotective Agents / Ovariectomy / PPAR gamma / Protein Transport / Rats / Rats, Wistar / Response Elements / STAT3 Transcription Factor / Thiazolidinediones / Transcriptional Activation
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.111.618926
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22076002; ● Search Scopus @ Elsevier (PMID): 22076002; ● Search Scopus @ Elsevier (DOI): 10.1161/STROKEAHA.111.618926

(DOI: 10.1161/STROKEAHA.111.618926, PubMed: 22076002) Nobuhisa Matsushita, Keiko T. Kitazato, Yoshiteru Tada, Manabu Sumiyoshi, Kenji Shimada, Kenji Yagi, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro :
Increase in body Na⁺-to-water ratio is associated with cerebral aneurysm formation in oophorectomized rats,
Hypertension, Vol.60, No.5, 1309-1315, 2012.

(要約): The incidence of cerebral aneurysms is higher in women than in men, especially postmenopause. Although hypertension is thought to be associated with a high incidence of stroke, not all patients with unruptured cerebral aneurysms are hypertensive. The possibility of water-free Na(+) storage associated with hypertension has been raised. However, whether the increase in the body Na(+)/water ratio that characterizes water-free Na(+) accumulation is associated with the formation of cerebral aneurysms remains obscure. To examine this relationship, Sprague-Dawley female rats subjected to carotid artery ligation were divided into 3 groups: a high-salt diet group (HSD) without and another with bilateral oophorectomy (HSD/OVX) and a third group that underwent additional renal artery ligation (HSD/OVX/RL). Compared with rats receiving a normal diet (shams), water retention was increased in HSD rats but not in HSD/OVX rats. Interestingly, compared with HSD rats, the incidence of cerebral aneurysms and the body Na(+)/water ratio were significantly higher in HSD/OVX and HSD/OVX/RL rats, independent of hypertension. In their aneurysmal wall, ATP12, a subtype of Na(+)/K(+)-ATPase, was downregulated, whereas inflammatory-related molecules were upregulated. Treatment with low-dose olmesartan that did not affect the blood pressure in hypertensive HSD/OVX/RL rats reduced the rate of cerebral aneurysm formation, body Na(+) retention, and the Na(+)/water ratio and upregulated ATP12. These results suggest that the increase in the Na(+)/water ratio and a reduction in ATP12 may be associated with cerebral aneurysm formation. We provide the new insight that the management of water-free Na(+) is important to prevent their development.
(キーワード): Angiotensin II Type 1 Receptor Blockers / Animals / Blood Pressure / Blotting, Western / Body Water / Carotid Arteries / Female / Humans / Hypertension / Imidazoles / Intracranial Aneurysm / Ligation / Ovariectomy / Rats / Rats, Sprague-Dawley / Renal Artery / Sodium / Sodium Chloride, Dietary / Sodium-Potassium-Exchanging ATPase / Tetrazoles / Up-Regulation / Water-Electrolyte Balance
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.112.198762
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23045463; ● Search Scopus @ Elsevier (PMID): 23045463; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.112.198762

(DOI: 10.1161/HYPERTENSIONAHA.112.198762, PubMed: 23045463) Norio Nakajima, Shinji Nagahiro, Toshiaki Sano, Junichiro Satomi, Kenji Yagi, Yoshiteru Tada, Keiko T. Kitazato and Koichi Satoh :
Krüppel-like zinc-finger transcription factor 5 (KLF5) is highly expressed in large and giant unruptured cerebral aneurysms.,
World Neurosurgery, Vol.78, No.1-2, 114-121, 2011.

(要約): Krüppel-like zinc-finger transcription factor 5 (KLF5), known as BTEB2 and IKLF, has several biological functions that involve cell proliferation, development, and apoptosis. In human cerebral aneurysms, macrophage infiltration is profoundly associated with growth and rupture, but the role of KLF5 remains unclear. We examined the significance of KLF5 expression in cerebral aneurysms. Unruptured (n=15) and ruptured (n=12) aneurysms obtained at surgery or autopsy were divided into 3 size groups: small (<10 mm); large (10 mm but <25 mm); and giant (25 mm). Control samples comprised 5 cerebral arteries obtained from surgery or autopsy subjects. The expression of KLF5-, -smooth muscle actin-, and KP-1 (macrophages) -positive cells were counted and compared between groups. Media of control arteries was negative for KLF5. In the luminal layers, KLF5 in unruptured small aneurysm was also negative; KLF5 expression was higher in unruptured large/giant aneurysms than other groups (P<0.05). KP-1 expression in unruptured large/giant aneurysms, ruptured small aneurysms, and ruptured large/giant aneurysms was higher than in unruptured small aneurysms (P<0.05). In the unruptured large/giant aneurysms, KP-1-positive cells were lower than KLF5-positive cells. On the other hand, irrespective of size, KLF5 positivity tended to be lower than KP-1 in the luminal and abluminal layers of all ruptured aneurysms. This represents the first documentation that KLF5 is highly expressed in large and giant unruptured aneurysms and that in ruptured aneurysmal wall KLF5 expression was scarce. These findings suggest that the KLF5 expression and macrophage infiltration play essential roles on aneurysmal growth or rupture.
(キーワード): Adult / Aged / Aneurysm, Ruptured / Female / Gene Expression / Humans / Intracranial Aneurysm / Kruppel-Like Transcription Factors / Macrophages / Male / Middle Aged / Muscle, Smooth, Vascular
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2011.05.052
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22120375; ● Search Scopus @ Elsevier (PMID): 22120375; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2011.05.052

(DOI: 10.1016/j.wneu.2011.05.052, PubMed: 22120375) Yoshiteru Tada, Keiko T. Kitazato, Kenji Yagi, Kenji Shimada, Nobuhisa Matsushita, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Statins Promote the Growth of Experimentally Induced Cerebral Aneurysms in Estrogen-Deficient Rats,
Stroke, Vol.42, No.8, 2286-2293, 2011.

(要約): The pathogenesis of cerebral aneurysms is linked to inflammation, degradation of the extracellular matrix, and vascular wall apoptosis. Statins exert pleiotropic effects on the vasculature, independent of their cholesterol-lowering properties. To explore the detailed pathogenesis of cerebral aneurysms, we examined their progression in a rat model and studied whether statins prevent their initiation and growth. Cerebral aneurysms were induced in female rats subjected to hypertension, increased hemodynamic stress, and estrogen deficiency. The development of aneurysm was assessed morphologically on corrosion casts. The effects of pravastatin (5, 25, or 50 mg/kg per day) and of simvastatin (5 mg/kg per day) on their aneurysms were studied. Human brain endothelial cells were also used to determine the effects of pravastatin. Pravastatin (5 mg/kg per day) reduced endothelial damage and inhibited aneurysm formation; there was an association with increased endothelial nitric oxide synthase (eNOS) levels and a decrease in human brain endothelial cell adhesion molecules. Unexpectedly, 25 mg/kg per day and 50 mg/kg per day pravastatin and 5 mg/kg per day simvastatin promoted aneurysmal growth, and high-dose pravastatin induced aneurysmal rupture. The deleterious effects exerted by these statins were associated with an increase in apoptotic caspase-3 levels and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells, suggesting that statins exert bidirectional effects. Our results provide the first evidence that cerebral aneurysm growth is partly associated with apoptosis and issue a warning that statins exert bidirectional effects on cerebral aneurysms. Additional intensive research is necessary to understand better their mechanisms and to identify patients in whom the administration of statins may elicit deleterious effects.
(キーワード): Animals / Apoptosis / Brain / Cells, Cultured / Disease Models, Animal / Endothelial Cells / Estrogens / Female / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hypertension / Intracranial Aneurysm / Nitric Oxide Synthase Type III / Pravastatin / Rats / Rats, Sprague-Dawley / Simvastatin
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.110.608034
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21737796; ● Search Scopus @ Elsevier (PMID): 21737796; ● Search Scopus @ Elsevier (DOI): 10.1161/STROKEAHA.110.608034

(DOI: 10.1161/STROKEAHA.110.608034, PubMed: 21737796) Kenji Shimada, Keiko T. Kitazato, Tomoya Kinouchi, Kenji Yagi, Yoshiteru Tada, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Activation of estrogen receptor- and of angiotensin-converting enzyme 2 suppresses ischemic brain damage in oophorectomized rats.,
Hypertension, Vol.57, No.6, 1161-1166, 2011.

(要約): Like the angiotensin II type 1 receptor blocker, endogenous estrogen (17-estradiol) is neuroprotective against cerebral ischemia; its effects are thought to be mediated by estrogen receptors (ERs). To verify the role of ERs and the brain renin-angiotensin system in estrogen-deficient rats with ischemia induced by middle cerebral artery occlusion, we compared rats subjected to oophorectomy (OVX(+)) with sham-oophorectomized rats (OVX(-)) and OVX(+) rats treated with 0.3 or 3.0 mg/kg of olmesartan for 2 weeks before middle cerebral artery occlusion. Independent of the blood pressure, the cortical infarct volume was larger in OVX(+) than in OVX(-) rats. It was smaller in olmesartan-pretreated OVX(+) rats. The expression of ER in the peri-infarct region was correlated with the reduction of cortical infarct but not that of ER or G protein-coupled estrogen receptor. Olmesartan prevented ER downregulation in the cortical peri-infarct area, without affecting ER or G protein-coupled estrogen receptor. Olmesartan also increased mRNA expression of angiotensin-converting enzyme 2, Bcl-2, and Bcl-xL and reduced angiotensin II and cleaved caspase 3. These effects were augmented by olmesartan and abolished by the ER inhibitor. In OVX(+) rats treated with the ER agonist alone, the infarct size was decreased, and the neuroprotective genes were upregulated. These findings suggest that the transactivation of neuroprotective genes and the reduction in brain angiotensin II are ER dependent and that this may augment neuroprotection together with an angiotensin II type 1 receptor blockade by olmesartan. We present the new insight that the activation of ER independent of estrogen contributes at least partly to limiting cerebral ischemic damage.
(キーワード): Angiotensin II / Angiotensin II Type 1 Receptor Blockers / Animals / 血圧 (blood pressure) / Blotting, Western / 脳 (brain) / Brain Ischemia / Caspase 3 / Dose-Response Relationship, Drug / Estrogen Receptor alpha / Female / 遺伝子発現 (gene expression) / Imidazoles / 免疫組織化学 (immunohistochemistry) / Ovariectomy / Peptidyl-Dipeptidase A / Pyrazoles / Rats / Rats, Wistar / Receptors, Angiotensin / Reverse Transcriptase Polymerase Chain Reaction / Tetrazoles / ras Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.110.167650
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21536991; ● Search Scopus @ Elsevier (PMID): 21536991; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.110.167650

(DOI: 10.1161/HYPERTENSIONAHA.110.167650, PubMed: 21536991) Yoshiteru Tada, Kenji Yagi, Keiko T. Kitazato, Tetsuya Tamura, Tomoya Kinouchi, Kenji Shimada, Nobuhisa Matsushita, Norio Nakajima, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats.,
Journal of Hypertension, Vol.28, No.9, 1883-1891, 2010.

(要約): OBJECTIVE: The formation of cerebral aneurysms is associated with endothelial damage and macrophage migration. Hypothesizing that the opening of tight junctions due to the disappearance of the tight junction proteins occludin and zona occludens-1 (ZO-1) in damaged endothelia allows macrophage migration, leading to cerebral aneurysm formation, we investigated the role of tight junction proteins. METHODS: The vascular wall of female rats subjected to hypertension, oophorectomy (OVX), and hemodynamic stress to induce cerebral aneurysms was evaluated morphologically, immunohistochemically, and by quantitative RT-PCR. We also assessed the regulation of tight junction proteins in human brain endothelial cells (HBECs). RESULTS: In the very early stage before aneurysm formation, the expression of occludin and ZO-1 was reduced in injured endothelial cell junctions exhibiting gaps. In the course of aneurysmal progression their reduction progressed and was correlated with macrophage migration. In hypertension along with OVX rats we observed an increase in angiotensin II and the degradation molecules matrix metalloproteinase-9 (MMP-9), nicotinamide-adenine dinucleotide phosphate oxidases and monocyte chemoattractant protein-1. The mineralocorticoid receptor blocker eplerenone increased occludin and ZO-1 expression; this was associated with a reduction in angiotensin II and the degradation molecules and resulted in the inhibition of macrophage exudation and aneurysm formation. In HBECs, occludin and ZO-1 downregulation by angiotensin II and estrogen deficiency was reversed by eplerenone, the MMP inhibitor SB3CT, and apocynin. Our results suggest that macrophage migration is associated with the reduction in tight junction proteins induced by the degradation molecules. CONCLUSION: In rats, the destruction of tight junctions may facilitate macrophage migration and cerebral-aneurysm formation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/HJH;0b013e32833c2273
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20577123; ● Search Scopus @ Elsevier (PMID): 20577123; ● Search Scopus @ Elsevier (DOI): 10.1097/HJH;0b013e32833c2273

(DOI: 10.1097/HJH;0b013e32833c2273, PubMed: 20577123) Kenji Yagi, Yoshiteru Tada, Keiko T. Kitazato, Tetsuya Tamura, Junichiro Satomi and Shinji Nagahiro :
Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats.,
Neurosurgery, Vol.66, No.3, 551-9;discussion559, 2010.

(要約): OBJECTIVE: Phosphodiesterase-4 (PDE-4) is a cyclic adenosine monophosphate-specific enzyme involved in various inflammatory diseases. We studied its role in and the effect of ibudilast, which predominantly blocks PDE-4, on rat cerebral aneurysms. METHODS: Cerebral aneurysms were induced at the anterior cerebral artery-olfactory artery bifurcation of female rats subjected to hypertension, increased hemodynamic stress, and estrogen deficiency. The effect of ibudilast (30 or 60 mg/kg/d for 3 months) on their cerebral aneurysms was studied by morphological and immunohistochemical assessment and quantitative real-time polymerase chain reaction assay. In our in vitro study, we grew endothelial cells stimulated by angiotensin II under estrogen-free conditions and examined the effect of ibudilast on PDE-4 activation and the cyclic adenosine monophosphate level. RESULTS: Morphological evaluation using vascular corrosion casts showed ibudilast significantly suppressed cerebral aneurysms in a dose-dependent manner. In rats with induced cerebral aneurysms, the gene and protein expression of PDE-4 was high, and endothelial leukocyte adhesion molecules (P-selectin, intracellular adhesion molecule 1, and vascular adhesion molecule 1), matrix metalloproteinase-9, and tumor necrosis alpha were expressed. Macrophage migration was also increased. Treatment with ibudilast down-regulated these molecules, suppressed macrophage migration into the aneurysm wall, and inhibited PDE-4 activation and the elevation of cyclic adenosine monophosphate in endothelial cells. CONCLUSION: These results suggest that blocking of PDE4 is associated with the reduction of inflammation-related molecules and macrophage migration, thereby reducing the progression of cerebral aneurysms. It may represent a new conservative therapy to treat patients with cerebral aneurysms.
(キーワード): Angiotensin II / Animals / Antigens, CD / Antigens, Differentiation, Myelomonocytic / Cell Line, Transformed / Cyclic AMP / Cyclic Nucleotide Phosphodiesterases, Type 4 / Disease Models, Animal / Down-Regulation / Endothelial Cells / Endothelium, Vascular / Female / Humans / Intercellular Adhesion Molecule-1 / Intracranial Aneurysm / Matrix Metalloproteinase 9 / P-Selectin / Phosphodiesterase Inhibitors / Pyridines / RNA, Messenger / Rats / Rats, Sprague-Dawley
(出版サイトへのリンク): ● Publication site (DOI): 10.1227/01.NEU.0000365771.89576.77
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20124930; ● Search Scopus @ Elsevier (PMID): 20124930; ● Search Scopus @ Elsevier (DOI): 10.1227/01.NEU.0000365771.89576.77

(DOI: 10.1227/01.NEU.0000365771.89576.77, PubMed: 20124930) Yoshiteru Tada, Masaaki Uno, Shunji Matsubara, Atsuhiko Suzue, Kenji Shimada, Naomi Morita, Masafumi Harada and Shinji Nagahiro :
Reversibility of ischemic findings on 3-T T2*-weighted imaging after emergency superficial temporal artery-middle cerebral artery anastomosis in patients with progressive ischemic stroke.,
Neurologia Medico-Chirurgica, Vol.50, No.11, 1006-1011, 2010.

(要約): Vascular ischemic signs, i.e. multiple hypointense vessels in the ischemic territory, were identified by gradient echo-type 3-T T(2)*-weighted magnetic resonance (MR) imaging in 3 patients with acute ischemia due to major vessel occlusion. Emergency superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis was performed in 2 patients with progressive stroke caused by bleeding-type moyamoya disease or severe MCA stenosis. Both patients were initially treated conservatively, but their neurological signs deteriorated. 3-T T(2)*-weighted MR imaging detected funicular low signals in both patients indicating enhancement of cortical vessels or medullary veins. The area of the vascular ischemic signs was almost the same or smaller than the hypoperfusion area on perfusion-weighted MR imaging or single-photon emission computed tomography. Postoperatively, the vascular ischemic signs disappeared in both patients, suggesting a relationship with severe ischemia due to high-risk misery perfusion. Their postoperative course was uneventful, and MR imaging revealed no new cerebral ischemic lesions or cerebral hyperperfusion. The patient without surgery developed cerebral infarction in the area of the vascular ischemic signs. Vascular ischemic signs detected by 3-T T(2)*-weighted MR imaging may represent a new predictor of high-risk misery perfusion, and may disappear after STA-MCA anastomosis performed in the subacute stage.
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.50.1006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21123987; ● Search Scopus @ Elsevier (PMID): 21123987; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.50.1006

(DOI: 10.2176/nmc.50.1006, PubMed: 21123987) Yoshiteru Tada, Keiko T. Kitazato, Tetsuya Tamura, Kenji Yagi, Kenji Shimada, Tomoya Kinouchi, Junichiro Satomi, Shinji Nagahiro and Shinji Nagahiro :
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.,
Hypertension, Vol.54, No.3, 552-557, 2009.

(要約): Activation of the renin-angiotensin (Ang)-aldosterone system is involved in the pathology of vascular diseases. Although the blockade of the mineralocorticoid receptor protects against vascular diseases, its role in cerebral aneurysms remains to be elucidated. We treated female rats subjected to renal hypertension, increased hemodynamic stress, and estrogen deficiency for 3 months with the mineralocorticoid receptor blocker eplerenone (30 or 100 mg/kg per day) or vehicle (vehicle control). Eplerenone reduced the incidence of cerebral aneurysms and saline intake without lowering of the blood pressure. In the aneurysmal wall, the production of Ang II and nitrotyrosine was increased. The mRNA levels of Ang-converting enzyme 1 and NADPH oxidase subunits NOX4, Rac1, monocyte chemoattractant protein 1, and matrix metalloproteinase 9 were increased. Eplerenone brought about a reduction in these molecules, suggesting that mineralocorticoid receptor blockade suppresses cerebral aneurysm formation by inhibiting oxidative stress, inflammatory factors, local renin-Ang system activation, and saline intake. Other female rats implanted with pellets of the mineralocorticoid receptor agonist deoxycorticosterone acetate manifested a high incidence of cerebral aneurysm formation and the upregulation of molecules related to oxidative stress, inflammatory factors, and the local renin-Ang system; their saline intake was increased. We demonstrate that mineralocorticoid receptor activation at least partly contributes to the pathogenesis of cerebral aneurysms.
(キーワード): Aldosterone / Angiotensin II / Animals / 血圧 (blood pressure) / Cerebral Arteries / Chemokine CCL2 / Female / 遺伝子発現 (gene expression) / Hypertension, Renal / 免疫組織化学 (immunohistochemistry) / Intracranial Aneurysm / Mineralocorticoid Receptor Antagonists / NADPH Oxidase / Ovariectomy / 酸化ストレス (oxidative stress) / Peptidyl-Dipeptidase A / RNA, Messenger / Rats / Rats, Sprague-Dawley / Receptors, Mineralocorticoid / レニン·アンジオテンシンシステム (Renin-angiotensin System) / Reverse Transcriptase Polymerase Chain Reaction / Spironolactone / Tyrosine
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.109.134130
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19620512; ● Search Scopus @ Elsevier (PMID): 19620512; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.109.134130

(DOI: 10.1161/HYPERTENSIONAHA.109.134130, PubMed: 19620512) Tetsuya Tamura, Mohammad A. Jamous, Keiko T. Kitazato, Kenji Yagi, Yoshiteru Tada, Masaaki Uno and Shinji Nagahiro :
Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats,
Journal of Hypertension, Vol.27, No.6, 1284-1292, 2009.

(要約): Epidemiological data indicate a high incidence of cerebral aneurysms in postmenopausal women. To elucidate the pathogenesis of cerebral aneurysms, we focused on the contribution of endothelial damage in rats. We induced estradiol deficiency by oophorectomy (OVX), hypertension, or both, and hemodynamic stress in 7-week-old female Sprague-Dawley rats. They were then given hormone-replacement therapy with 17beta-estradiol or an angiotensin II type 1 receptor blocker (ARB). The effects of estradiol, angiotensin II type 1 receptor blocker, or both on cultured endothelial cells were also examined. The number of anomalously shaped endothelial cells was higher in OVX than hypertensive rats (P < 0.05). Rats subjected to hypertension and OVX exhibited a marked increase in the incidence of saccular cerebral aneurysms. Estradiol or angiotensin II type 1 receptor blocker treatment reduced this incidence (P < 0.05). The endothelial nitric oxide synthase (eNOS) mRNA level in the intracranial artery of OVX and hypertensive and OVX rats was low (P < 0.05). Immunohistochemically, the expression of eNOS and estrogen receptor alpha (ERalpha) in the vascular wall of hypertensive and OVX rats was decreased; angiotensin II and the nicotinamide adenine dinucleotide phosphate oxidase subunits nicotinamide adenine dinucleotide phosphate oxidase 4 and p22phox were strongly expressed in cerebral aneurysms. In the absence of estradiol, eNOS was downregulated and nicotinamide adenine dinucleotide phosphate oxidase expression was increased in endothelial cells; angiotensin II augmented these phenomena. The regulation of eNOS was mediated by ERalpha. These results suggest that estrogen deficiency induces endothelial dysfunction and reactive oxygen species generation, triggering endothelial damage that leads to cerebral aneurysms and that hypertension is an additional risk factor. A therapy targeted at the endothelium and management of hypertension may help to prevent cerebral aneurysms.
(キーワード): Angiotensin II / Angiotensin II Type 1 Receptor Blockers / Animals / Base Sequence / Benzimidazoles / Biphenyl Compounds / 血圧 (blood pressure) / Corrosion Casting / DNA Primers / Endothelium, Vascular / Estradiol / Estrogen Replacement Therapy / Female / Humans / Hypertension / Intracranial Aneurysm / NADPH Oxidase / 一酸化窒素 (nitric oxide) / Nitric Oxide Synthase Type III / Ovariectomy / 酸化ストレス (oxidative stress) / RNA, Messenger / Rats / Rats, Sprague-Dawley / Tetrazoles
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/HJH.0b013e328329d1a7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19307983; ● Search Scopus @ Elsevier (PMID): 19307983; ● Search Scopus @ Elsevier (DOI): 10.1097/HJH.0b013e328329d1a7

(DOI: 10.1097/HJH.0b013e328329d1a7, PubMed: 19307983) Kenji Yagi, Keiko T. Kitazato, Masaaki Uno, Yoshiteru Tada, Tomoya Kinouchi, Kenji Shimada and Shinji Nagahiro :
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasmininogen activator,
Stroke, Vol.40, No.2, 626-631, 2009.

(要約): Intracerebral hemorrhage, induced by recombinant tissue plasminogen activator (rtPA) in ischemic stroke, is attributable to the increased activity of matrix metalloproteinase-9 (MMP-9). Patients with acute infarct benefit from the neuroprotective drug edaravone, a free radical scavenger. We examined the mechanisms by which edaravone may help to suppress rtPA-induced brain hemorrhage. Male Wistar rats weighing 250 to 280 g were subjected to 3-hour transient middle cerebral artery occlusion (MCAO) and divided randomly into 3 groups. Immediately after reperfusion, 1 group was intravenously injected with 10 mg/kg rtPA, another with rtPA plus 3 mg/kg edaravone, and the 3rd group received no treatment. We assessed the hemorrhage volume and the activity of MMP-9 in the brain 24 hours postischemia. We also studied the activity of MMP-9, its mRNA expression, and nuclear factor-kappa B (NF-kappaB) activity in rtPA-stimulated human microvascular endothelial cells (HBECs). The degree of hemorrhage and the level of endothelial cell-derived MMP-9 were elevated in rats treated with rtPA alone and attenuated in rats treated with rtPA plus edaravone. In rtPA-stimulated HBECs, edaravone suppressed the activity and mRNA expression of MMP-9 in a dose-dependent manner. Edaravone also inhibited NF-kappaB activation. We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs. Edaravone may render thrombolytic therapy safer for the administration of rtPA in patients with ischemic stroke.
(キーワード): Animals / Antipyrine / 血圧 (blood pressure) / Blotting, Western / Brain Ischemia / Cells, Cultured / Cerebral Hemorrhage / Dose-Response Relationship, Drug / Endothelial Cells / Free Radical Scavengers / 免疫組織化学 (immunohistochemistry) / Infarction, Middle Cerebral Artery / Male / Matrix Metalloproteinase 9 / Middle Cerebral Artery / NF-kappa B / RNA, Messenger / Rats / Rats, Wistar / Reperfusion Injury / Reverse Transcriptase Polymerase Chain Reaction / Tissue Plasminogen Activator
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.108.520262
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19095969; ● Search Scopus @ Elsevier (PMID): 19095969; ● Search Scopus @ Elsevier (DOI): 10.1161/STROKEAHA.108.520262

(DOI: 10.1161/STROKEAHA.108.520262, PubMed: 19095969) H Liu, KT Kitazato, Masaaki Uno, Kenji Yagi, Yasuhisa Kanematsu, Tetsuya Tamura, Yoshiteru Tada, Tomoya Kinouchi and Shinji Nagahiro :
Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies,
Journal of Hypertension, Vol.26, No.7, 1435-1445, 2008.

(要約): Angiotensin II type 1 (AT1) receptor blockers decrease ischemia by mechanisms dependent on and independent of arterial blood pressure in hypertensive rats and AT1-R knockout mice, respectively. However, the detailed mechanisms underlying the effects of AT1 receptor blockers remain unclear. To elucidate the systemic and focal effects of AT1 receptor blockers against cerebral ischemia in in-vivo and in-vitro studies. Normotensive Wistar rats were treated for 2 weeks with 0.5 or 1 mg/kg candesartan cilexetil and then subjected to 2-h middle cerebral artery occlusion-reperfusion. Human umbilical endothelial cells were stimulated with the active form of candesartan and angiotensin II in the absence and presence of an angiotensin II type 2 (AT2) receptor antagonist. In candesartan-pretreated hypotensive and nonhypotensive rats, blood pressure was moderately increased during middle cerebral artery occlusion and fell gradually to the baseline after the reperfusion; it remained elevated in the control even after the reperfusion occlusion. Candesartan treatment resulted in a decrease in the cortical infarct volume and oxidative damage, the hypoxic status was improved, and the expression of repair-associated and growth-associated proteins in the cortical penumbra was augmented. Candesartan also increased the eNOS mRNA level and the lumen size of the middle cerebral artery. In human umbilical endothelial cells, candesartan increased the eNOS protein level AT2-R dependently, inhibited the expression of nicotinamide adenine dinucleotide phosphate oxidase subunits and angiotensin II-induced intracellular reactive oxygen species and nitric oxide, and promoted the extracellular release of nitric oxide, suggesting that it augmented the bioavailability of nitric oxide. Among the mechanisms candesartan exerts in its protection against cerebral ischemia, restoration of endothelial function may represent an attractive therapeutic goal to address cerebral ischemia.
(キーワード): Angiotensin II Type 1 Receptor Blockers / Animals / Benzimidazoles / Biphenyl Compounds / Brain Ischemia / Disease Models, Animal / Endothelium, Vascular / Ligation / Middle Cerebral Artery / Nitric Oxide / Nitric Oxide Synthase Type II / Nitric Oxide Synthase Type III / Oxidative Stress / Rats / Rats, Wistar / Reactive Oxygen Species / Reperfusion Injury / Tetrazoles / Vasodilation
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/HJH.0b013e3283013b6e
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18551021; ● Search Scopus @ Elsevier (PMID): 18551021; ● Search Scopus @ Elsevier (DOI): 10.1097/HJH.0b013e3283013b6e

(DOI: 10.1097/HJH.0b013e3283013b6e, PubMed: 18551021)

MISC

多田恵曜, 平澤元浩, 牟礼英生, 里見淳一郎, 山本信昭, 阿部考志 :
T2強調画像で脊髄内に高信号を呈する病変,
脳神経外科速報, Vol.24, No.11, 1194-1197, 2014年. 平井聡, 桑山一行, 多田恵曜, 里見淳一郎, 阿部考志, 藤田浩司 :
T2*強調画像における脳静脈洞，皮質静脈の低信号病変,
脳神経外科速報, Vol.24, No.7, 700-704, 2014年.

総説・解説

高麗雅章, 多田恵曜, 北里慶子, 橋本友紀, 髙木康志 :
脳動脈瘤の発生のメカニズム,
Clinical Neuroscience, Vol.41, No.10, 1332-1335, 2023年10月.

(キーワード): 脳動脈瘤 (brain aneurysm) / くも膜下出血

講演・発表

Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Peri-ictal normal arterial spin labeling imaging in patients with seizures,
13 回アジア・オセアニアてんかん学会(13th AOEC), Jun. 2021. Tadashi Yamaguchi, Keiko T Kitazato, Eiji Shikata, Idumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu and Yasushi Takagi :
Pro-inflammatory response promoted by Porphyromonas gingivalis lipopolysaccharide enhances the rupture of experimental intracranial aneurysms.,
Brain and Brain PET2019, Yokohama, Jul. 2019. Tadashi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yoshiteru Tada, Yasuhisa Kanematsu, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi :
Estrogen deficiency activates inflammasome in a rat model of intracranial aneurysms,
11th World Stroke Congress 2018, Montreal, Oct. 2018. Masaaki Korai, Yasuhisa Kanematsu, Yoshiteru Tada, Idumi Yamaguchi, Nobuaki Yamamoto, Yuki Yamamoto and Junichiro Satomi :
Treatment strategy and outcome of ruptured vertebral artery dissecting aneurysms,
14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017. Junichiro Satomi, Yasuhisa Kanematsu, Masaaki Korai, Yuki Yamamoto, Nobuaki Yamamoto, Yoshifumi Mizobuchi, Hideo Mure, Yoshiteru Tada, Kohhei Nakajima, Toshiyuki Okazaki and Toshitaka Fujihara :
Acute stroke management using image sharing on smart phones and tablet devices,
14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017. Takeshi Miyamoto, Yoshiteru Tada, Kenji Shimada, Kenji Yagi, Masaaki Korai, Hidetsugu Maekawa, Tadashi Yamaguchi, Syotaro Soshioka, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro :
Pro-inflammatory Response Elicited by Porphyromonas Gingivalis Lipopolysaccharide Exacerbates the Rupture of Experimental Cerebral Aneurysms,
International Stroke Conference 2017, Houston, Feb. 2017. Takeshi Miyamoto, Keiko Kitazato, Hidetsugu Maekawa, Tadashi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshitaka Kurashiki, syotaro Yoshioka, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro :
Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats,
25th European Stroke Conference, Apr. 2016. Yoshitaka Kurashiki, Keiko Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Tomoya Kinouchi, Manabu Sumiyoshi, Takeshi Miyamoto, Tadashi Yamaguchi, Junichiro Satomi, Yoshihiro Uto and Shinji Nagahiro :
Activation of M2 macrophages in the late phase of cerebral ischemia may contribute to phagocytosis of infarct area and neurogenesis,
25th European Stroke Conference, Apr. 2016. Syotaro Yoshioka, Yoshiteru Tada, Junichiro Satomi, Kenji Yagi, Koji Naruishi, Kazuyuki Kuwayama, Keiko Kitazato, Takeshi Miyamoto, Yasuhisa Kanematsu, Masafumi Harada, Toshihiko Nagata and Shinji Nagahiro :
Impact of Periodontal Disease and Bacteria on Intracranial Aneurysms,
International Stroke Conference 2016, Los Angeles, Feb. 2016. Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Tomoya Kinouchi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Masaaki Korai, Hideo Mure, Keiko Kitazato and Shinji Nagahiro :
A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms,
International Stroke Conference 2016, Los Angeles, Feb. 2016. Manabu Sumiyoshi, Kenji Yagi, Takeshi Miyamoto, Yoshitaka Kurashiki, Nobuhisa Matsushita, Tomoya Kinouchi, Yoshiteru Tada, Kazuyuki Kuwayama, Junichiro Satomi and Shinji Nagahiro :
The accumulation of brain water-free Na+ may be a detrimental factor of ischemic damage independent of hypertension in female rats,
The 8th International Aldosterone Forum in Japan, May 2015. Takeshi Miyamoto, Masaaki Korai, David K. Kung, Keiko K. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshitaka Kurashiki, Kazuyuki Kuwayama, Junichiro Satomi and Shinji Nagahiro :
Hemodynamic changes elicit the formation and rupture of experimental cerebral aneurysms,
International stroke conference, Nashville, Feb. 2015. Masaaki Korai, Kenji Yagi, Keiko T. Kitazato, Yoshiteru Tada, Junichiro Satomi and Shinji Nagahiro :
Hyperhomocysteinemia is associated with vulnerability of the cerebral aneurysmal wall to rupture in ovariectomized rats.,
International stroke conference, Nashville, Feb. 2015. Yoshitaka Kurashiki, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Manabu Sumiyoshi, 宮本健志, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Predominant Activation of M2 Macrophages by Group-specific Component Protein-derived Macrophage Activating,
INTERNATIONAL STROKE CONFERENCE 2015, Feb. 2015. Masaaki Korai, Kenji Shimada, Yoshiteru Tada and Shinji Nagahiro :
INTERNATIONAL STROKE CONFERENCE 2015 Roles of Macrophage PPAR on Intracranial Aneurysmal Rupture,
INTERNATIONAL STROKE CONFERENCE 2015, Feb. 2015. 宮本健志, Masaaki Korai, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Yoshitaka Kurashiki, Kazuyuki Kuwayama, Junichiro Satomi and Shinji Nagahiro :
Hemodynamic Changes May Be Partly Attributable To The Formation And Rupture Of Aneurysms In A Rat Model,
INTERNATIONAL STROKE CONFERENCE 2015, Feb. 2015. Junichiro Satomi, Yoshiteru Tada, Takashi Abe, Kazuyuki Kuwayama, Ryuji Kaji, Nobuaki Yamamoto, Masafumi Harada and Shinji Nagahiro :
Intra-arterial signal on arterial spin labeling perfusion MRI can identify stagnant flow in patients with acute middle cerebral rtery occlusion,
INTERNATIONAL STROKE CONFERENCE 2015, Nashville, USA, Feb. 2015. 伊藤弘道, 森健治, 東田好広, 藤原敏孝, 多田恵曜, 中島公平, 影治照喜, 飯田幸治, 永廣信治, 高橋幸利, 香美祥二 :
VNSにより発作頻度，認知行動面に改善が認められたAERRPSの1例,
第9回日本てんかん学会中国・四国地方会, 2015年2月. Yoshitaka Kurashiki, K.T Kitazato, Kung K David, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Junichiro Satomi, Y Uto and Shinji Nagahiro :
Effects of the immunostimulant GcMAF in cerebral ischemia,
Congress Of Neurological Surgeons 2013 Annual Meeting, San Francisco, Oct. 2013. Masaaki Korai, David K Kung, K.T Kitazato, Nobuhisa Matsushita, Yoshiteru Tada, Kenji Yagi, Kenji Shimada, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro :
Role of hyperhomocysteinemia in the development of intracranial aneurysms,
Congress Of Neurological Surgeons 2013 Annual Meeting, San Francisco, Oct. 2013. T Fujihara, Junichiro Satomi, Yasuhisa Kanematsu, Yoshiteru Tada, Kenji Yagi, Yoshifumi Mizobuchi, Teruyoshi Kageji and Shinji Nagahiro :
Delayed intra-arterial urokinase thrombolysis based on MRI criteria has similar outcome compared to intravenous t-PA within 3 hours,
Congress Of Neurological Surgeons 2013 Annual Meeting, San Francisco, Oct. 2013. Masaaki Korai, DK Kung, KT Kitazato, Nobuhisa Matsushita, Yoshiteru Tada, Kenji Yagi, Yasuhisa Kanematsu, Junichiro Satomi and Shinji Nagahiro :
Imbalance between activation of matrix metalloprotease and its inhibition may facilitate the growth of cerebral aneurysm in female rats,
International Stroke Conference 2013, Honolulu, Feb. 2013. Tomoya Kinouchi, Yoshitaka Kurashiki, 北里慶子, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Junichiro Satomi, Masataka Sata and Shinji Nagahiro :
Post-stroke PPAR activation promotes the proliferation and differentiation of innate- and bone marrow-derived stem cells insubventricular zone, leading to vasogenesis and neurogenesis in cortex,
International STROKE Conference 2013, Honolulu, Feb. 2013. Keiko T. Kitazato, Yoshiteru Tada, Tetsuya Tamura, Kenji Yagi, Kenji Shimada, Nobuhisa Matsushita, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Vascular Mineralcorticoid Receptor Antagonism Combined with A Decrease in Salt-intake By Eplerenone Inhibits Cerebral Aneurysm without Affecting Blood Pressure,
International Stroke Conference 2011, LosAngels, Feb. 2012. KT Kitazato, Yoshiteru Tada, Tetsuya Tamura, Kenji Yagi, Kenji Shimada, Nobuhisa Matsushita, Tomoya Kinouchi, Yasuhisa Kanematsu, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Vascular mineralcorticoid receptor antagonism combined with a decrease in salt-intake by eplerenone inhibits cerebral aneurysm without affecting blood pressure,
International Stroke Conference 2011, Los Angeles, Oct. 2011. KT Kitazato, Tomoya Kinouchi, Kenji Shimada, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Yasuhisa Kanematsu, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Role of Nuclear receptors on neuroprotection after experimental cerebral ischemia in female rats,
115th International Symposium on Cerebral Blood Flow Metabolism and Function, Barcelona, May 2011. Kenji Shimada, Keiko T. Kitazato, Tomoya Kinouchi, Kenji Yagi, Yoshiteru Tada, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Activation of estrogen receptor a and of ace2 suppresses ischemic brain damage in oophorectomized rats,
115th International Symposium on Cerebral Blood Flow,Metabolism,and Function, Barcelona, May 2011. Kenji Shimada, Keiko T. Kitazato, Tomoya Kinouchi, Kenji Yagi, Yoshiteru Tada, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Up-regulation of estrogen receptor alpha with down-regulation of the brain renin-angiotensin system by olmesartan contributes to neuroprotection against cerebral infarction in estrogen-deficient rats,
International Stroke Conference 2011, Los Angeles, Feb. 2011. Kenji Shimada, Keiko T. Kitazato, Tomoya Kinouchi, Kenji Yagi, Yoshiteru Tada, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Activation of estrogen receptor and inhibition of local renin angiotensin system against cerebral ischenmia in oophorectomized rats,
The 1st World Forum on Cerebral Blood Flow Metabolism & Function, Kyoto, Oct. 2010. Kenji Shimada, Tomoya Kinouchi, KT Kitazato, Yoshiteru Tada, Kenji Yagi, Teruyoshi Kageji and Shinji Nagahiro :
Role of Estrogen receptors in cerebral ischemia in female rats; Contribution of angiotensintype 1 receptor blocker,
XIV World Congress of Neurological Surgery, Boston, Aug. 2009. Tomoya Kinouchi, Keiko T. Kitazato, Kenji Yagi, Kenji Shimada, Yoshiteru Tada, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro :
Pioglitazone promotes neuroprotection through the activation of STAT3 against cerebral ischemia in female rats,
XIV World Congress of Neurological Surgery, Boston, Aug. 2009. Yoshiteru Tada, Keiko T. Kitazato, Tetsuya Tamura, Kenji Yagi, Kenji Shimada, Tomoya Kinouchi, Nobuhisa Matsushita, Junichiro Satomi and Shinji Nagahiro :
Eplerenone Suppresses the Progression of Experimentally-induced Cerebral Aneurysms in Rats,
XIV World Congress of Neurological Surgery, Boston, Aug. 2009. Kenji Yagi, Keiko T. Kitazato, Yoshiteru Tada, Tetsuya Tamura, Kazuhito Matsuzaki, Junichiro Satomi and Shinji Nagahiro :
Cyclic Nucleotide Phosphodiesterase 4-Related Vascular Inflammation Contributes to the Progression of Cerebral Aneurysm,
XIV World Congress of Neurological Surgery, Boston, Aug. 2009. Yoshiteru Tada, Keiko T. Kitazato, Tetsuya Tamura, Kenji Yagi, Kenji Shimada, Tomoya Kinouchi, Junichiro Satomi and Shinji Nagahiro :
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats,
The 6th International Intracranial Stent Meeting 2009, Sendai, Aug. 2009. Kenji Yagi, Keiko T. Kitazato, Yoshiteru Tada, Tetsuya Tamura, Kazuhito Matsuzaki, Junichiro Satomi and Shinji Nagahiro :
Cyclic Nucleotide Phosphodiesterase 4-Related Vascular Inflammation Contributes to the Progression of Cerebral Aneurysms,
09AANS ANNUAL MEETING, California, May 2009. 藤原敏孝, 多田恵曜, 安積麻衣, 原慶次郎, 中島公平, 髙木康志 :
てんかん重積状態を来した脳腫瘍症例の臨床的特徴と治療成績,
日本脳神経外科学会第83回学術総会, 2024年10月. 多田恵曜, 藤原敏孝, 高麗雅章, 宮本健志, 島田健司, 髙木康志 :
くも膜下出血急性期における非けいれん性てんかん重積状態の転帰,
日本脳神経外科学会第83回学術総会, 2024年10月. 藤原敏孝, 多田恵曜, 中島公平, 原慶次郎, 安積麻衣, 髙木康志 :
テント上髄膜腫手術症例におけるてんかん発作および周術期管理についての検討,
第57回日本てんかん学会学術集会, 2024年9月. 多田恵曜, 藤原敏孝, 髙木康志 :
非けいれん性てんかん重積におけるASLでの陰性所見に関与する因子に関する検討,
第57回日本てんかん学会学術集会, 2024年9月. 多田恵曜 :
脳神経外科医が行うてんかん診断から薬物治療・外科治療まで,
第44回日本脳神経外科コングレス総会, 2024年5月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激療法を必要とした80歳以上の高齢者てんかんの特徴と治療経験,
第37回日本老年脳神経外科学会, 2024年4月. 多田恵曜, 藤原敏孝, 髙木康志 :
80歳以上の高齢者てんかんに対する迷走神経刺激療法の治療経験,
第18回日本てんかん学会中国・四国地方会, 2024年2月. 多田恵曜, 藤原敏孝, 髙木康志 :
側頭葉の解剖と前側頭葉切除術の進め方,
第47回日本てんかん外科学会, 2024年2月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激療法を必要とした80歳以上の高齢者てんかんの特徴と治療経験,
第47回日本てんかん外科学会, 2024年2月. 多田恵曜, 藤原敏孝, 冨田江一, 飯田幸治, 髙木康志 :
未固定遺体による前頭葉離断術，前頭葉切除術に対するトレーニング,
第47回日本てんかん外科学会, 2024年2月. 多田恵曜, 藤原敏孝, 髙木康志 :
非けいれん性てんかん重積におけるASLでの陰性所見に関与する因子に関する検討,
日本脳神経外科学会第82回学術総会, 2023年10月. 藤原敏孝, 中島公平, 原慶次郎, 安積麻衣, 松田拓, 多田恵曜, 髙木康志 :
脳腫瘍生検術におけるStealth Autoguideの初期使用経験,
日本脳神経外科学会第82回学術集会, 2023年10月. 藤原敏孝, 多田恵曜, 髙木康志 :
高齢発症てんかんの特徴と治療経験,
第56回日本てんかん学会学術集会, 2023年10月. 多田恵曜, 藤原敏孝, 泉千恵, 福田直也, 中瀧理仁, 森達夫, 山﨑博輝, 髙木康志 :
「誰も取り残さない」てんかんの医療費助成・福祉サービスの提供,
第56回日本てんかん学会学術集会, 2023年10月. 森達夫, 多田恵曜, 中瀧理仁, 田山貴広, 郷司彩, 東田好広, 藤原敏孝, 山﨑博輝, 森健治 :
徳島大学病院てんかんセンターにおけるトランジションの現状と今後の課題,
第10回全国てんかんセンター協議会総会栃木大会 2023, 2023年3月. 山口泉, 兼松康久, 溝渕佳史, 多田恵曜, 宮本健志, 曽我部周, 石原学, 鹿草宏, 山本陽子, 松田拓, 北里慶子, 髙木康志 :
硬膜転移が慢性硬膜下血腫の転帰に及ぼす影響についての後視的検討,
第46回日本脳神経外傷学会, 2023年2月. 藤原敏孝, 多田恵曜, 中島公平, 手島奈津美, 髙木康志 :
深部電極留置におけるStealth Autoguideの初期使用経験:Posterior quadrantectomyを行った薬剤抵抗性てんかんの1例,
第17回日本てんかん学会中国・四国地方会, 2023年2月. 多田恵曜, 中瀧理仁, 森達夫, 藤原敏孝, 郷司彩, 山﨑博輝, 泉千恵, 高尾里沙, 多田雅美, 阿部修司, 森健治, 髙木康志 :
地方におけるてんかん支援拠点病院の役割,
第10回全国てんかんセンター協議会, 2023年2月. 藤原敏孝, 多田恵曜, 髙木康志 :
てんかん外科へのアクセス困難な地域における診療支援,
第10回全国てんかんセンター協議会, 2023年2月. 多田恵曜, 藤原敏孝, 板東康司, 山本陽子, 髙木康志 :
てんかん重積に対して迷走神経刺激療法を施行した5例,
第46回日本てんかん外科学会, 2023年1月. 藤原敏孝, 多田恵曜, 板東康司, 髙木康志 :
Posterior quadrantectomyが有効であった脳腫瘍術後薬剤抵抗性てんかんの1例,
第46回日本てんかん外科学会, 2023年1月. 高麗雅章, 橋本友紀, 宮本健志, 北里慶子, 四方英二, 山口真司, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
Neutrophil extracellular trapsは脳動脈瘤破裂を促進する,
日本脳神経外科学会第81回学術総会, 2022年9月. 兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 :
徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み,
日本脳神経外科学会第81回学術総会, 2022年9月. 多田恵曜, 藤原敏孝, 島田健司, 兼松康久, 髙木康志 :
傍発作時におけるASLおよびDWI所見と発作型の関連性について,
第55回日本てんかん学会学術集会, 2022年9月. 平野愛子, 北村愛里, 重根裕代, 川原みゆき, 藤原敏孝, 多田恵曜, 森健治, 髙木康志 :
長時間ビデオ脳波モニタリング実施時の発作時観察力向上のための取り組み∼発作観察時のビデオ作成発作時対応のシミュレーションの実施∼.,
, 2022年3月. 高尾里沙, 多田雅美, 安部修司, 中瀧理仁, 森達夫, 藤原敏孝, 多田恵曜, 山﨑博輝, 森健治 :
てんかん相談における徳島県の現状の把握と今後の課題.,
第9回全国てんかんセンター協議会総会鹿児島大会, 2022年3月. 多田恵曜, 中瀧理仁, 森達夫, 藤原敏孝, 郷司彩, 山﨑博輝, 高尾里沙, 泉千恵, 多田雅美, 安部修司, 森健治 :
今後の徳島県におけるてんかん地域診療連携整備事業の展望について,
第9回全国てんかんセンター協議会総会, 2022年3月. 兼松康久, 藤原敏孝, 島田健司, 多田恵曜, 髙木康志 :
外傷性内頚動脈海綿静脈洞瘻による静脈環流障害から非けいれん性てんかん重積をきたした一例,
第45回日本脳神経外傷学会, 2022年2月. 藤原敏孝, 多田恵曜, 片桐匡弥, 香川幸太, 飯田幸治, 髙木康志 :
比較的長時間持続する両側口角のけいれんを主とする薬剤抵抗性てんかんに対し迷走神経刺激療法を施行した1例,
第16回日本てんかん学会中国・四国地方会, 2022年2月. 藤原敏孝, 多田恵曜, 髙木康志 :
迷走神経刺激装置交換時のリード損傷により全システムの交換を要した1例,
第45回日本てんかん外科学会, 2022年1月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 飯田幸治, 髙木康志 :
未固定遺体による半球離断術に対する手術トレーニング,
第45回日本てんかん外科学会, 2022年1月. 藤原敏孝, 多田恵曜, 溝渕佳史, 中島公平, 原慶次郎, 安積麻衣, 髙木康志 :
テント上髄膜腫手術症例におけるてんかん及び周術期発作管理の検討,
日本脳神経外科学会第80回学術総会, 2021年10月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 髙木康志 :
未固定遺体によるてんかん外科に対する手術トレーニング,
NMC Case Report Journal, 2021年10月. 兼松康久, 金澤裕樹, 島田健司, 曽我部周, 宮本健志, 石原学, 四方英二, 山口泉, 多田恵曜, 山本雄貴, 山本伸昭, 原田雅史, 髙木康志 :
CEST MRIを用いた頚動脈プラーク診断 Chemical exchange saturation transfer MRI for carotid plaque imaging,
NMC Case Report Journal, 2021年10月. 多田恵曜, 藤原敏孝, 鶴尾吉宏, 飯田幸治, 髙木康志 :
未固定遺体による半球離断術に対する手術トレーニング,
第54回日本てんかん学会学術集会, 2021年9月. 多田恵曜, 藤原敏孝, 佐藤裕一, 飯田幸治, 髙木康志 :
2期的に半球離断術を施行した成人片側巨脳症の1例,
第15回日本てんかん学会中国・四国地方会, 2021年2月. 藤原敏孝, 多田恵曜, 島田健司, 兼松康久, 髙木康志 :
内頚動脈海綿静脈洞瘻に急性症候発作重積を合併した1例,
第14回日本てんかん学会中国・四国地方会, 2020年2月. 藤原敏孝, 多田恵曜, 安積麻衣, 髙木康志 :
海馬からのてんかん性放電が乏しかった海馬硬化症の1例,
第7回全国てんかんセンター協議会広島大会, 2020年2月. 多田恵曜, 東田好広, 中瀧理仁, 藤原敏孝, 森達夫, 郷司彩, 飯田幸治, 森健治, 髙木康志 :
徳島県におけるてんかん地域診療連携整備事業の活動状況,
第7回全国てんかんセンター協議会広島大会, 2020年2月. 多田恵曜, 藤原敏孝, 香川幸太, 片桐匡弥, 瀬山剛, 飯田幸治, 髙木康志 :
遠隔てんかん症例検討会による薬剤抵抗性側頭葉てんかん治療方針の決定について,
第43回日本てんかん外科学会, 2020年1月. 藤原敏孝, 多田恵曜, 兼松康久, 髙木康志 :
Wadatestにて言語優位半球を同定できなかった薬剤抵抗性側頭葉てんかんの一例,
第43回日本てんかん外科学会, 2020年1月. 山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
エストロゲン欠乏脳動脈瘤ラットモデルにおけるERαの低下とNLRP3 inflammasome活性の関係,
第62回日本脳循環代謝学会学術集会, 2019年11月. 兼松康久, 島田健司, 高麗雅章, 宮本健志, 多田恵曜, 山本雄貴, 山本伸昭, 里見淳一郎, 髙木康志 :
当院での急性期脳底動脈閉塞に対する血管内治療成績,
第35回日本脳神経血管内治療学会学術総会, 2019年11月. 中瀧理仁, 江戸宏彰, 多田恵曜, 東田好広, 藤原敏孝, 森達夫, 郷司彩, 森健治, 大森哲郎 :
てんかん発作や精神症状と関連しない生活の質,
第53回日本てんかん学会学術集会, 2019年11月. 藤原敏孝, 多田恵曜, 溝渕佳史, 中島公平, 安積麻衣, 髙木康志 :
脳腫瘍手術における周術期抗てんかん薬使用と術後発作抑制効果についての検討,
第53回日本てんかん学会学術集会, 2019年10月. 多田恵曜, 東田好広, 中瀧理仁, 藤原敏孝, 森達夫, 郷司彩, 飯田幸治, 森健治, 髙木康志 :
徳島県におけるてんかん地域診療連携整備事業の紹介,
第53回日本てんかん学会学術集会, 2019年10月. 山口真司, 宮本健志, 北里慶子, 四方英二, 山口泉, 高麗雅章, 島田健司, 多田恵曜, 兼松康久, 髙木康志 :
脳動脈瘤破裂モデルにおける部位特異的な早期形態変化と血管崩壊関連分子の変動,
日本脳神経外科学会第78回学術集会, 2019年10月. 多田恵曜, 藤原敏孝, 中島公平, 安積麻衣, 髙木康志 :
高齢発症てんかんの臨床的特徴,
日本脳神経外科学会第78回学術集会, 2019年10月. 兼松康久, 島田健司, 高麗雅章, 宮本健志, 山口泉, 山口真司, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 :
当院における急性期脳底動脈閉塞に対する治療成績,
日本脳神経外科学会第78回学術集会, 2019年10月. 宮本健志, 北里慶子, 多田恵曜, 島田健司, 高麗雅章, 山口真司, 兼松康久, 髙木康志 :
Porphyromonas gingivalis LPSは脳動脈瘤モデルラットにおいて脳動脈瘤破裂を促進する,
日本脳神経外科学会第78回学術集会, 2019年10月. 藤原敏孝, 溝渕佳史, 中島公平, 安積麻衣, 多田恵曜, 髙木康志 :
脳腫瘍手術における周術期抗てんかん薬使用の現状,
Neurologia Medico-Chirurgica, 2019年10月. 兼松康久, 島田健司, 高麗雅章, 岡﨑敏之, 多田恵曜, 里見淳一郎, 永廣信治, 髙木康志 :
当院における高齢者(80歳以上)くも膜下出血の治療成績と予後の検討,
日本脳神経外科学会第77回学術総会, 2018年10月. 里見淳一郎, 吉岡正太郎, 宮本健志, 成石浩司, 北里慶子, 多田恵曜, 原田雅史, 髙木康志, 永廣信治 :
脳動脈瘤と歯周病との関連,
日本脳神経外科学会第77回学術総会, 2018年10月. 多田恵曜, 藤原敏孝, 中島公平, 森健治, 髙木康志 :
高齢発症てんかんの臨床的特徴，新規抗てんかん薬の効果,
日本脳神経外科学会第77回学術総会, 2018年10月. 高麗雅章, 山口泉, 多田恵曜, 兼松康久, 里見淳一郎, 山本伸昭, 山本雄貴, 髙木康志 :
地方国立大学病院における院内発症脳卒中症例の特徴,
第43回日本脳卒中学会学術集会, 2018年3月. 庄野健児, 里見淳一郎, 多田恵曜, 兼松康久, 山本伸昭, 和泉唯信, 梶龍兒, 原田雅史, 永廣信治, 髙木康志 :
Optimal timing of DWI to avoid false-negative findings in patients with TIA,
第41回日本脳神経CI学会総会, 2018年3月. 多田恵曜, 藤原敏孝, 郷司彩, 森達夫, 東田好広, 森健治, 飯田幸治, 里見淳一郎, 髙木康志 :
術前精査中にバルブロ酸の追加が著効したrolandic crtical dysplasiaに1例,
第41回日本てんかん外科学会, 2018年1月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 原田雅史, 里見淳一郎, 永廣信治 :
非痙攣性てんかん重積診断におけるArterial Spin Labeling法の有用性,
第51回日本てんかん学会年次学術集会, 2017年11月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 原田雅史, 里見淳一郎, 永廣信治 :
当院で経験した非痙攣性てんかん重積症例の検討,
日本脳神経外科学会第76回学術総会, 2017年10月. 高麗雅章, 木内智也, 多田恵曜, 兼松康久, 里見淳一郎, 永廣信治 :
当院における院内発症脳卒中症例の検討,
第4回日本心血管脳卒中学会学術集会, 2017年6月. 日岡明美, 多田恵曜, 北里慶子, 出口純次, 篠原宏美, 阿部巧規, 松本真巳, 里見淳一郎, 永廣信治 :
回復期脳卒中患者の歩行障害に対する運動観察治療の効果,
第8回日本ニューロリハビリテーション学会, 2017年4月. 高麗雅章, 橋本友紀, 北里慶子, 多田恵曜, 木内智也, 兼松康久, 里見淳一郎, 永廣信治 :
脳動脈瘤破裂におけるNeutrophil eztracellular tropの役割,
第42回日本脳卒中学会学術集会, 2017年3月. 里見淳一郎, 多田恵曜, 山本伸昭, 梶龍兒, 原田雅史, 永廣信治 :
超急性期脳梗塞に必要な画像診断:Stroke MRI用,
第42回日本脳卒中学会学術集会, 2017年3月. 兼松康久, 里見淳一郎, 高麗雅章, 木内智也, 山口泉, 多田恵曜, 松原俊二, 佐藤浩一, 永廣信治 :
くも膜下出血で発症した，解離性椎骨動脈瘤の治療方針と成績,
第46回日本脳卒中の外科学会学術集会, 2017年3月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 飯田幸治, 永廣信治 :
同側の未破裂中大脳動脈瘤を合併した左海馬硬化症による難治性内側側頭葉てんかんの一例,
第11回てんかん学会中国・四国地方会, 2017年2月. 多田恵曜, 藤原敏孝, 中島公平, 東田好広, 伊藤弘道, 森達夫, 郷司彩, 飯田幸治, 森謙治, 永廣信治 :
徳島大学てんかんセンターの取り組みと課題,
全国てんかんセンター協議会総会 JEPICA 2017 in Nara, 2017年2月. 多田恵曜, 山本伸昭, 梶龍兒, 原田雅史, 永廣信治 :
超急性期脳梗塞に必要な画像診断:Stroke MRI,
第42回日本脳卒中学会学術集会, 2017年2月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 里見淳一郎, 原田雅史, 永廣信治 :
Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性,
第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月. 兼松康久, 里見淳一郎, 山口泉, 木内智也, 多田恵曜, 山本伸昭, 山本伸昭, 松原俊二, 佐藤浩一, 永廣信治 :
神経症状の改善および安定化を目的として行ったUrgent CASの有効性および安全性の検討,
第32回NPO法人日本脳神経血管内治療学会学術総会, 2016年11月. 宮本健志, 山口真司, K.Kung David, 北里慶子, 多田恵曜, 島田健司, 八木謙次, 高麗雅章, 兼松康久, 里見淳一郎, 永廣信治 :
新規脳動脈瘤破裂モデルにおける破裂動脈瘤の病態解明,
第59回日本脳循環代謝学会学術集会, 2016年11月. 高麗雅章, 北里慶子, 多田恵曜, 宮本健志, 島田健司, 八木謙次, 松下展久, 兼松康久, 里見淳一郎, 永廣信治 :
メチオニン過剰摂取による高ホモシステイン血症は崩壊しやすい特定脳動脈壁の炎症反応を増強し脳動脈瘤破裂を促進する,
第59回日本脳循環代謝学会学術集会, 2016年11月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 里見淳一郎, 原田雅史, 永廣信治 :
Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性,
第50回日本てんかん学会学術集会, 2016年10月. 多田恵曜, 山本伸昭, 藤原敏孝, 中島公平, 香川幸太, 片桐匡弥, 飯田幸治, 梶龍兒, 永廣信治 :
自己免疫性介在性脳炎後の難治性てんかんの1例,
第50回日本てんかん学会学術集会, 2016年10月. 山口真司, 多田恵曜, 里見淳一郎, 山口泉, 吉岡正太郎, 木内智也, 兼松康久, 永廣信治 :
くも膜下出血後のDIND発症例における脳梗塞の検討,
日本脳神経外科学会第75回学術総会, 2016年9月. 藤原敏孝, 多田恵曜, 中島公平, 牟礼英生, 里見淳一郎, 原田雅史, 永廣信治 :
Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性,
日本脳神経外科学会第75回学術総会, 2016年9月. 多田恵曜, 兼松康久, 里見淳一郎, 桑山一行, 八木謙次, 木内智也, 中島公平, 高麗雅章, 牟礼英生, 宮本健志, 山口真司, 北里慶子, 永廣信治 :
高血圧症合併未破裂脳動脈瘤に対するミネラルコンチコイド受容体阻害薬の有効性に関するパイロット試験,
日本脳神経外科学会第75回学術総会, 2016年9月. 兼松康久, 里見淳一郎, 山口泉, 木内智也, 多田恵曜, 西京子, 松原俊二, 宇野昌明, 佐藤浩一, 永廣信治 :
リスク回避に基づいた難易度の高い頚動脈狭窄症の治療戦略,
日本脳神経外科学会第75回学術総会, 2016年9月. 日岡明美, 溝渕佳史, 中村和己, 多田恵曜, 牟礼英生, 西京子, 北里慶子, 里見淳一郎, 永廣信治 :
年代別健常者の高次脳機能障害スクリーニングテストの特性,
第17回日本早期認知症学会学術集会, 2016年9月. 松田拓, 住吉学, 山口泉, 吉岡正太郎, 多田恵曜, 八木謙次, 曽我部周, 山本伸昭, 桑山一行, 里見淳一郎, 永廣信治 :
MRI CUBE T1が診断の一助となった前大脳動脈解離による脳梗塞の一例,
第80回(一社)日本脳神経外科学会中国四国支部学術集会, 2015年12月. 山口泉, 曽我部周, 吉岡正太郎, 多田恵曜, 桑山一行, 里見淳一郎, 山本伸昭, 永廣信治 :
椎骨脳底動脈閉塞に対するarterial spin labelingの動脈内高信号の有用性,
第31回NPO法人日本脳神経血管内治療学会学術総会,, 2015年11月. 桑山一行, 山口泉, 曽我部周, 吉岡正太郎, 多田恵曜, 里見淳一郎, 山本伸昭, 永廣信治 :
内頚動脈急性閉塞に対する血管内治療の有効性,
第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月. 曽我部周, 里見淳一郎, 多田恵曜, 吉岡正太郎, 山口泉, 山本伸昭, 永廣信治 :
Stent retriever導入後の当院での急性期血行再建術,
第31回NPO法人日本脳神経血管内治療学会学術総会, 2015年11月. 宮本健志, Kung K David, 北里慶子, 前川秀継, 八木謙次, 島田健司, 多田恵曜, 倉敷佳孝, 吉岡正太郎, 桑山一行, 里見淳一郎, 永廣信治 :
ラット脳動脈瘤モデルにおける脳動脈瘤増大・破裂に及ぼす血行力学的負荷の影響,
第27回日本脳循環代謝学会, 2015年10月. 多田恵曜, 藤原敏孝, 中島公平, 影治照喜, 東田好広, 伊藤弘道, 森健治, 香川幸太, 飯田幸治, 永廣信治 :
発作時に過呼吸をきたす前頭葉てんかんの1例,
第49回日本てんかん学会学術集会, 2015年10月. 倉敷佳孝, 北里慶子, 多田恵曜, 八木謙次, 住吉学, 宮本健志, 桑山一行, 里見淳一郎, 島田健司, 木内智也, 宇都義浩, 永廣信治 :
脳虚血後後期におけるGcMAF投与はM2 macrophageを増加させ神経再生に寄与する,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 吉岡正太郎, 多田恵曜, 桑山一行, 八木謙次, 里見淳一郎, 宮本健志, 北里慶子, 成石浩司, 永田俊彦, 原田雅史, 永廣信治 :
歯周病の重症度および原因菌は脳動脈瘤の発生と破裂に関与する,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 山口泉, 多田恵曜, 里見淳一郎, 永廣信治 :
椎骨脳底動脈閉塞に対するarterial spin labelingの動脈内高信号の有用性,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 前川秀継, 宮本健志, 北里慶子, 多田恵曜, 八木謙次, 里見淳一郎, 永廣信治 :
ラット血栓化膿動脈瘤のvasa vasorumの3次元構造,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 宮本健志, 北里慶子, 前川秀継, 八木謙次, 島田健司, 多田恵曜, 倉敷佳孝, 吉岡正太郎, 桑山一行, 里見淳一郎, 永廣信治, K.Kung David :
ラット脳動脈瘤モデルにおける脳動脈瘤増大・破裂に及ぼす血行力学的負荷の影響,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 多田恵曜, 八木謙次, 北里慶子, 桑山一行, 島田健司, 里見淳一郎, 永廣信治, 宇野昌明 :
脳血管障害の既住がある高血圧症例に対するオルメサルタンの降圧効果と臓器保護作用,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 山本伸昭, 里見淳一郎, 原田雅史, 多田恵曜, 永廣信治, 梶龍兒 :
Is the susceptibility vessel sign on 3-tesla magnetic resonance T2*-weighted imaging a useful tool to predict recanalization?,
第2回日本心血管脳卒中学術総会 2015, 2015年6月. 山本伸昭, 多田恵曜, 里見淳一郎, 和泉唯信, 原田雅史, 永廣信治, 梶龍兒 :
The two-layered susceptibility vessel sign on 3-tesla T2*-weighted imaging is a predictive biomarker of stroke subtype,
2015年心血管脳卒中学術総会, 2015年6月. 永廣信治, 里見淳一郎, 桑山一行, 多田恵曜, 曽我部周, 山口泉, 吉岡正太郎, 佐田政隆 :
当院SCUにおける心疾患を合併した脳卒中症例,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 住吉学, 里見淳一郎, 北里慶子, 鈴江涼子, 八木謙次, 島田健司, 多田恵曜, 桑山一行, 永廣信治 :
脳梗塞におけるHigh mobility group box-1シグナル活性化とエイコサペントエン酸による脳保護作用,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 倉敷佳孝, 北里慶子, 島田健司, 八木謙次, 多田恵曜, 木内智也, 住吉学, 宮本健志, 桑山一行, 里見淳一郎, 永廣信治, 宇都義浩 :
脳虚血後後期におけるGroup-specific protein-derived macrophage activating factor (GcMAF)投与は，M2 macrophage,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 宮本健志, 北里慶子, 高麗雅章, 八木謙次, 多田恵曜, 倉敷佳孝, 桑山一行, 里見淳一郎, 永廣信治 :
ラットモデルにおける血行力学的変化と脳動脈瘤形成および破裂の関係,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 原田雅史, 山本伸昭 :
Arterial spin labelingの動脈内高信号は急性期中大脳動脈閉塞におけるstagnant flowを反映する,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 曽我部周, 多田恵曜, 里見淳一郎, 桑山一行, 吉岡正太郎, 山口泉, 永廣信治, 山本伸昭, 山田博胤, 若槻哲三, 佐田政隆 :
当院における院内発症脳卒中症例の検討,
第2回日本心血管脳卒中学会学術集会, 2015年6月. 里見淳一郎, 多田恵曜, 桑山一行, 永廣信治, 山本伸昭, 八木謙次, 曽我部周, 吉岡正太郎 :
内頸動脈- 前脈絡叢動脈分岐部動脈瘤に対する治療成績,
第44回日本脳卒中の外科学会, 2015年3月. 桑山一行, 曽我部周, 多田恵曜, 里見淳一郎, 永廣信治, 山本伸昭 :
病態別にみた急性期頸動脈ステント留置術(CAS)の成績,
第40回日本脳卒中学会総会, 2015年3月. 曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭 :
当院でのstent retrieverの初期使用経験,
第40回日本脳卒中学会総会, 2015年3月. 伊藤弘道, 東田好弘, 香美祥二, 森健司, 藤原敏孝, 多田恵曜, 中島公平, 影治照喜, 永廣信治, 飯田幸治, 高橋幸利 :
VNSにより発作頻度，認知行動面に改善が認められたAERRPSの1例,
第9回日本てんかん学会中国・四国地方会, 2015年2月. 多田恵曜, 藤原敏孝, 中島公平, 影治照喜, 永廣信治, 東田好弘, 伊藤弘道, 森健司, 香川幸太, 飯田幸治 :
発作時に過換気をきたす前頭葉てんかんの1例,
第9回日本てんかん学会中国・四国地方会, 2015年2月. 山本伸昭, 和泉唯信, 梶龍兒, 里見淳一郎, 多田恵曜, 永廣信治 :
頸動脈ステント留置後のIn stent plaqueの予測因子,
第30回日本脳神経血管内治療学術総会, 2014年12月. 曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭, 和泉唯信 :
小脳萎縮をきたした横静脈洞―S状静脈洞部硬膜動静脈瘻の一例,
第30回日本脳神経血管内治療学術総会, 2014年12月. 山本伸昭, 和泉唯信, 梶龍兒, 曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治 :
The high-intense signal on maximum intensity projection images (MIP) of time-of-flight (TOF) magnetic resonance angiography (MRA) can be a predictor of plaque-in-stent after carotid artery stenting,
2014年脳血管内治療学会総会, 2014年12月. 宮本健志, 高麗雅章, 北里慶子, 島田健司, 八木謙次, 多田恵曜, 倉敷佳孝, 里見淳一郎, 永廣信治, Kung K David :
ラットモデルにおける血行力学的変化と脳動脈瘤形成および破裂の関係,
第26回日本脳循環代謝学会, 2014年11月. 山口真司, 多田恵曜, 里見淳一郎, 桑山一行, 曽我部周, 永廣信治, 山本伸昭 :
3テスラT2*強調画像のischemic vessel sign はCEA，CAS術後過灌流の予測に有用か,
第26回日本脳循環代謝学会, 2014年11月. 多田恵曜, 住吉学, 里見淳一郎, 北里慶子, 倉敷佳孝, 桑山一行, 永廣信治 :
脳梗塞におけるHigh mobility group box-1シグナル活性化とEPAによる脳保護作用,
第26回日本脳循環代謝学会, 2014年11月. 影治照喜, 倉敷佳孝, 北里慶子, 島田健司, 八木謙次, 多田恵曜, 木内智也, 住吉学, 宮本健志, 里見淳一郎, 宇都義弘, 永廣信治 :
虚血後後期におけ脳るGroup-specific protein-derived macrophage activating factor(GcMAF)によるM2 macrophage,
第26回日本脳循環代謝学会, 2014年11月. 多田恵曜, 里見淳一郎, 桑山一行, 曽我部周, 永廣信治, 山本伸昭 :
CEA，CAS術後過灌流の予測における3テスラT2*強調画像の虚血所見の検討,
第73回日本脳神経外科学会学術総会, 2014年10月. 藤原敏孝, 多田恵曜, 永廣信治 :
迷走神経刺激装置植込術を施行した難治性てんかんの一例,
第26回徳島てんかん談話会, 2014年7月. 多田恵曜, 里見淳一郎, 曽我部周, 桑山一行, 永廣信治, 阿部考志, 原田雅史, 山本伸昭 :
中大脳動脈閉塞例におけるarterial spin labelingの動脈内高信号の検討,
第1回日本心血管脳卒中学会学術集会, 2014年6月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
2014年脳卒中学会総会, 2014年3月. 中島公平, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭 :
脳卒中発症時のエイコサペンタエン酸/アラキドン酸比の検討,
第39回日本脳卒中学会総会, 2014年3月. 曽我部周, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治, 山本伸昭 :
脳主幹動脈急性閉塞に対する機械的血栓回収療法の治療成績,
第39回日本脳神経学会総会, 2014年3月. 山本伸昭, 多田恵曜, 里見淳一郎, 永廣信治, 兼松康久 :
脳梗塞発症後早期からの抗血小板薬使用が予後に及ぼす影響の検討,
第39回日本脳卒中学会総会, 2014年3月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
第39回日本脳卒中学会総会, 2014年3月. 里見淳一郎, 桑山一行, 多田恵曜, 曽我部周, 永廣信治, 山本伸昭 :
大型脳動脈瘤に対する治療戦略 -開頭術と血管内治療の使い分け-,
第43回日本脳卒中の外科学会, 2014年3月. 藤原敏孝, 多田恵曜, 中島公平, 香川幸太, 影治照喜, 飯田幸治, 永廣信治 :
側方性の診断に頭蓋内電極からの脳波記録が有用であった難治性内側側頭葉てんかんの1例,
第47回日本てんかん外科学会, 2014年2月. 藤原敏孝, 中島公平, 多田恵曜, 影治照喜, 永廣信治 :
当院におけるてんかん外科治療の取り組み,
第39回徳島脳神経外科談話会, 2013年12月. 里見淳一郎, 兼松康久, 多田恵曜, 桑山一行, 西京子, 永廣信治, 松原俊二, 宇野昌明, 佐藤浩一 :
長期成績からみたCASの有用性:CEA第1選択施設における検討,
第29回日本脳神経血管内治療学会学術総会, 2013年11月. 桑山一行, 多田恵曜, 里見淳一郎, 永廣信治 :
80歳以上の破裂脳動脈瘤治療の可能性と限界,
第29回NPO法人日本脳神経血管内治療学会学術総会, 2013年11月. 桑山一行, 里見淳一郎, 多田恵曜, 永廣信治 :
Yステントを用いてコイル塞栓術を行った脳底動脈先端部動脈瘤の1例,
第22回中国四国脳神経血管内手術研究会, 2013年9月. 石原学, 多田恵曜, 里見淳一郎, 永廣信治 :
脳血管内治療後に開頭手術を追加した椎骨脳底動脈解離の2例,
第15回徳島脳血管障害カンファレンス, 2013年4月. 多田恵曜, 八木謙次, 松下展久, 山本伸昭, 兼松康久, 里見淳一郎, 永廣信治 :
80歳以上の破裂脳動脈瘤の予後検討,
第42回日本脳卒中の外科学会, 2013年3月. 松下展久, 八木謙次, 多田恵曜, 兼松康久, 里見淳一郎, 永廣信治 :
脳卒中ケアユニットにおけるクモ膜下出血後遅発性脳虚血障害の現状と今後の課題,
第29回スパズム・シンポジウム, 2013年3月. 松下展久, 北里慶子, 多田恵曜, 住吉学, 高麗雅章, 兼松康久, 里見淳一郎, 永廣信治 :
体内水分貯留に対するナトリウム貯留の割合の増加は卵巣摘出ラットにおける脳動脈瘤形成と関係がある,
第38回日本脳卒中学会総会, 2013年3月. 多田恵曜, 和田浩輔, 牧野洋, Liang Elena, 村上晶子, 工藤真理, 橋本友紀, 北里慶子, 兼松康久, 永廣信治 :
卵巣摘出マウスにおいて，エストロゲンはエストロゲン受容体-betaを介して脳動脈瘤破裂を抑制する,
第38回日本脳卒中学会総会, 2013年3月. 松下展久, 多田恵曜, 兼松康久, 里見淳一郎, 永廣信治 :
徳島大学病院脳卒中センターにおける最近の急性期脳卒中診療,
第15回徳島脳卒中研究会, 2013年2月. 兼松康久, 多田恵曜, 松下展久, 北里慶子, 里見淳一郎, 永廣信治 :
臨床研究:REDUCE PILOT study 進捗状況,
第38回徳島脳神経外科談話会, 2012年12月. 多田恵曜, 牟礼英生, 山本伸昭, 兼松康久, 平澤元浩, 里見淳一郎, 永廣信治, 佐藤浩一 :
発症様式の異なる脊髄硬膜外動静脈瘻の2症例,
第28回NPO法人日本脳神経血管内治療学会学術総会, 2012年11月. 高麗雅章, 里見淳一郎, 山本伸昭, 松下展久, 多田恵曜, 兼松康久, 永廣信治 :
内頚動脈Carotid cave動脈瘤に対する血管内治療,
社団法人日本脳神経外科学会第71回学術総会, 2012年10月. 島田健司, 北里慶子, 木内智也, 八木謙次, 多田恵曜, 里見淳一郎, 影治照喜, 永廣信治 :
オルメサルタンによる脳梗塞抑制効果の新たなメカニズム;estrogen receptor αと脳内のRASの制御,
第36回日本脳卒中学会総会, 2011年7月. 多田恵曜 :
ラット脳動脈瘤モデルにおけるミネラルコルチコイド受容体の役割について,
第33回日本バイオレオロジー学会, 2010年6月. 多田恵曜 :
新規マウス脳動脈瘤モデルを用いた，脳動脈瘤におけるマクロファージの役割,
第33回日本バイオレオロジー学会, 2010年6月. 島田健司, 北里慶子, 木内智也, 八木謙次, 多田恵曜, 里見淳一郎, 影治照喜, 永廣信治 :
卵巣摘出ラットにおけるオルメサルタンの組織RASの抑制を介した脳梗塞の抑制効果について,
第39回日本脳卒中の外科学会, 2010年4月. 多田恵曜, 森垣龍馬, 島田健司, 鈴江淳彦, 西京子, 宇野昌明, 永廣信治 :
急性期STA-MCA anastomosisの検討,
第36回日本脳卒中の外科学会, 2007年3月.

研究会・報告書: 羽星辰哉, 多田恵曜, 藤原敏孝, 亘雄也, 中島公平, 髙木康志 :
前方脳梁離断術を施行した成人難治性てんかんの2例,
第43回徳島脳神経外科談話会, 2017年12月. 藤原敏孝, 多田恵曜, 永廣信治 :
当院で経験した非痙攣性てんかん重積症例の検討,
第4回徳島脳神経疾患談話会, 2017年3月. 多田恵曜, 藤原敏孝, 中島公平, 永廣信治 :
慢性頭蓋内電極留置後に左選択的偏桃体海馬切除を行った症例,
第42回徳島脳神経外科談話会, 2016年12月. 大北真哉, 藤原敏孝, 中島公平, 多田恵曜, 溝渕佳史, 永廣信治 :
Awake suegery ― 当院でのfirst case,
第3回徳島脳神経疾患談話会, 2016年3月. 藤原敏孝, 多田恵曜, 中島公平, 里見淳一郎, 永廣信治 :
WADAテストの実際,
第41回徳島脳神経外科談話会, 2015年12月. 多田恵曜, 藤原敏孝, 中島公平, 影治照喜, 永廣信治 :
ビデオ脳波モニタリングの有用性,
第27回徳島てんかん談話会, 2015年7月. 山本伸昭, 和泉唯信, 梶龍兒, 曽我部周, 吉岡正太郎, 多田恵曜, 桑山一行, 里見淳一郎, 永廣信治 :
急性期再灌流療法施行患者の予後予測因子,
第17回徳島脳血管障害カンファレンス, 2015年5月.

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 脳血管障害に影響を及ぼす特定歯周病菌の同定とその制御法の検討 (研究課題/領域番号: 23K08500 )
脳動脈瘤破裂におけるinflammasome活性化とsirtuinの役割 (研究課題/領域番号: 20K09391 )
歯周病巣のexosomeによる脳動脈瘤破裂への影響 (研究課題/領域番号: 20K09326 )
脳動脈瘤と歯周病に関する臨床および基礎的研究 (研究課題/領域番号: 17K10832 )
脳動脈瘤破裂予防を目指したinflammasomeに関する基礎的研究 (研究課題/領域番号: 17K10831 )
脳動脈瘤形成・破裂に対する選択的エストロゲン受容体作動薬の役割 (研究課題/領域番号: 15K19972 )
脳動脈瘤と歯周病に関する臨床および基礎的研究 (研究課題/領域番号: 15K10305 )
脳動脈瘤破裂の病態解析と早期診断・薬物治療へのアプローチ (研究課題/領域番号: 15H04950 )
脳血管障害におけるエストロゲン受容体モジュレーターの有効性と分子機構 (研究課題/領域番号: 26462159 )
未破裂脳動脈瘤の破裂予防に関する基礎研究 (研究課題/領域番号: 25861279 )
脳動脈瘤形成増大における体内塩分貯留の意義と分子機序 (研究課題/領域番号: 24592131 )
脳動脈瘤破裂の分子機構と薬物制御 (研究課題/領域番号: 24390344 )
脳動脈瘤形成・増大におけるスタチンの二面性作用 (研究課題/領域番号: 21591844 )
脳動脈瘤増大・破裂における分子機構と薬物制御 (研究課題/領域番号: 21390412 )
脳動脈瘤形成におけるタイトジャンクション蛋白の関与について (研究課題/領域番号: 20591686 )
研究者番号（30547964）による検索

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2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
所属学会・所属協会: 日本脳神経外科学会
委員歴・役員歴: 日本脳神経外科学会 (評議員 [2006年8月〜2013年])
受賞: 2011年10月, 奨励賞 (日本脳神経外科学会)
2013年2月, Globus New Investigator Award (International STROKE Conference)
2014年10月, 特別賞 (日本脳神経外科学会)
2014年12月, 若手研究者学長賞 (徳島大学)
2015年7月, 青藍会賞(徳島大学)
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研究者番号: 30547964

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 講師

所属（過去の研究課題 情報に基づく）*注記: 2017/4/1 – 2023/4/1 : 徳島大学, 病院, 特任講師
2017/4/1 : 徳島大学, 大学病院, 特任講師
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 講師
2015/4/1 : 徳島大学, 大学病院, 助教
2014/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教
2013/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 助教
2010/4/1 – 2011/4/1 : 徳島大学, 病院, 助教
2009/4/1 : 徳島大学, 医学部・歯学部付属病院, 助教
2009/4/1 : 徳島大学, 医学部・歯学部附属病院, 助教

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学
小区分56010:脳神経外科学関連

キーワード

研究代表者

脳動脈瘤破裂 / エストロゲン / くも膜下出血 / 脳・神経、脳神経疾患 / 脳・神経 / 脳神経疾患 / 選択的エストロゲン受容体作動薬 / 脳 / エストロゲン欠乏 / inflammasome / 脳動脈瘤 / 薬物治療 / Inflammasome

研究代表者以外

脳動脈瘤 / タイトジャンクション蛋白 / mineral corticoid receptor / phosphodiesterase / 血管内皮障害 / angiotensin II / エストロゲン / 炎症 / ラット / cccludin / ZO-1 / マクロファージ / タイトジャンクショク蛋白 / 高血圧 / 酸化ストレス / 脳・神経 / 脳血管病 / 脳動脈瘤破裂 / 血行動態変化 / 結構動態変化 / 脳血管障害 / くも膜下出血 / 破裂脳動脈瘤 / 高塩食 / 高塩分摂取 / 体内塩分貯留 / ミネラルコルチコイド受容体 / 脳神経疾患 / ミネラルコルチコイド / エストロゲン受容体α/β / エストロゲン受容体調節薬 / エストロゲン受容体作動薬(SERM） / エストロゲン受容体作動薬（SERM） / 歯周病 / 歯周菌 / 炎症反応 / エストロゲン受容体調整薬 / 脳動脈瘤破裂　血行動態変化 / 脳 / 歯周病菌 / 血管障害 / 頚動脈病変 / SAH / intracranial aneurysms / periodontal disease / periodontal bacteria / exosome / sirtuin / ERα / 破裂性脳血管病 / Inflammasome / NLRP3 / ERa / NLRP3　inflammasome / Sirtuin / NLRP3 inflammasome / 重症歯周病 / 脳梗塞 / クモ膜下出血 / NETosis

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多田 恵曜

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