トップ›研究者を探す›肝細胞癌で強発現するWT1, PKRのC型肝炎ウイルス発癌・進展における臨床的役割

肝細胞癌で強発現するWT1, PKRのC型肝炎ウイルス発癌・進展における臨床的役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21590848
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 愛媛大学
代表研究者 日浅 陽一
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴） 2011年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2010年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2009年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード WT1遺伝子
PKR
肝細胞癌
アポトーシス
C型肝炎ウイルス
interleukin-8
Caspase
siRNA
PCRアレイ
H77
Annexin V
HCV粒子生成可能複製系
細胞増殖
細胞接着因子

研究成果

[雑誌論文] Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8

Tokumoto Y, Hiasa Y, Uesugi K, 他7名、2番目 2012

[雑誌論文] Rivabirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8

Tokumoto Y, Hiasa Y, Uesugi K, 他7名 2012

[雑誌論文] Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus

Konishi I, Hiasa Y, Tokumoto Y, 他5名 2011

[雑誌論文] Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

Chayama K, Hayes CN, Hiasa Y, 他14名 2011

[雑誌論文] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

Tanaka Y, Kurosaki M, Hiasa Y, 他19名 2011

[雑誌論文] Splenic elasticity measured with real-time tissue elastography is a marker of portal hypertension

Hirooka M, Ochi H, Hiasa Y, 他6名 2011

[図書] 動物モデルによるHBV増殖とその応用B型肝炎ウイルス研究の進歩

日浅陽一、恩地森一 2011

[図書] 新時代のウイルス性肝炎学III B型肝炎3)動物モデルによるHBV増殖とその応用

日浅陽一、恩地森一 2011

[雑誌論文] Sustained virological response of patients with hepatitis C virus genotype 2 depends on pegylated interferon compliance

Watanabe T, Konishi I, Hiasa Y, 他12名 2011

[雑誌論文] Hepatic elasticity in patients with ascites : evaluation with real-time tissue elastography

Hirooka M, Koizumi Y, Hiasa Y, 他4名, 3番目 2011

[雑誌論文] Liver Fibrosis in Patients with Chronic Hepatitis C : Noninvasive Diagnosis by Means of Real-time Tissue Elastography-Establishment of the Method for Measurement

Koizumi Y, Hirooka M, Hiasa Y, 他6名 2011

[雑誌論文] Hepatic elasticity in patients with ascites : evaluation with real-time tissue elastography

Hirooka M, Koizumi Y, Hiasa Y, 他4名 2011

[学会発表] Characterization of ZNF689 in Human Hepatocellular Carcinoma as a Novel Target for Chemotherapy

Shigematsu S, Hiasa Y, Fukuda S, 他3名 2011

[雑誌論文] Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b

Sakamoto N, Nakagawa M, Hiasa Y, 他17名 2011

[雑誌論文] Splenic elasticity measured with real-time tissue elastography is a marker of portal hypertension

Hirooka M, Ochi H, Hiasa Y, 他6名, 8番目 2011

[学会発表] Characterization of ZNF689 in Human Hepatocellular Carcinoma as a Novel Target for Chemotherapy

Shigematsu S, Hiasa Y, Fukuda S, 他3名、2番目 2011

[学会発表] Up-regulated Wilms' tumor 1 gene functions in anti-apoptosis : potential therapeutic target for hepatocellular carcinoma

Uesugi K, Koizumi Y, Hiasa Y, (他8名、3番目) 2010

[雑誌論文] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo

Kasama Y, Sekiguchi S, Hiasa Y, 他8名 2010

[雑誌論文] Immune modulator and antiviral potential of dendritic cells pulsed with both hepatitis B surface antigen and core antigen for treating chronic HBV infection

Akbar SM, Yoshida O, Hiasa Y, 他5名 2010

[雑誌論文] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C

Chayama K, Hayes CN, Hiasa Y, 他14名 2010

[雑誌論文] Variability of the polymerase gene(NS5B) in HCV-infected women

Blackard JT, Ma G, Hiasa Y, 他8名 2010

[雑誌論文] Liver Fibrosis in Patients with Chronic Hepatitis C : Noninvasive Diagnosis by Means of Real-time Tissue Elastography--Establishment of the Method for Measurement

Koizumi Y, Hirooka M, Hiasa Y, (他6名、8番目) 2010

[雑誌論文] Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women

Blackard JT, Ma G, Hiasa Y, (他8名、7番目) 2010

[図書] クリニカルトピックスWilms' tumor 1遺伝子と肝細胞癌

日浅陽一、上杉和寛、恩地森一 2010

[雑誌論文] Mass reduction by radiofrequency ablation before hepatic arterial infusion chemotherapy improved prognosis for patients with huge hepatocellular carcinoma and portal vein thrombus

Hirooka M, Koizumi Y, Hiasa Y, 他5名 2010

[雑誌論文] Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease

Miyake T, Akbar SM, Hiasa Y, 他5名 2010

[雑誌論文] Safety and immunogenicity of hepatitis B surface antigen-pulsed dendritic cells in patients with chronic hepatitis B

Akbar SM, Furukawa S, Hiasa Y, 他3名 2010

[学会発表] Up-regulated Wilms' tumor 1 gene functions in anti-apoptosis : potential therapeutic target for hepatocellular carcinoma

Uesugi K, Koizumi Y, Hiasa Y, 他8名 2010

[雑誌論文] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo

Kasama Y, Sekiguchi S, Hiasa Y, (他8名、9番目) 2010

[雑誌論文] Mechanism of restoration of immune responses of patients with chronic hepatitis B during lamivudine therapy : increased antigen processing and presentation by dendritic cells

Akbar SM, Horiike N, Hiasa Y, 他5名 2010

[雑誌論文] Genome-wide association of IL28B with response to pegylated interferon-αand ribavirin therapy for chronic hepatitis C

Tanaka Y, Nishida N, Hiasa Y, 他26名 2009

[雑誌論文] Etiology of liver cirrhosis in Japan : a nationwide survey

Michitaka K, Nishiguchi S, Hiasa Y, 他3名 2009

[雑誌論文] Hepatocellular carcinoma for the non-specialist

Kumagi T, Hiasa Y, Hirschfield GM 2009

[学会発表] Decrease of SOCS-3 by ME3738 contributes to its synergistic anti-HCV effects when combined with type I interferon

Hiasa Y, Tokumoto Y, Konishi I, 他4名 2009

[雑誌論文] Diabetes pattern on the 75 g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus

Konishi I, Hiasa Y, Shigematsu S, 他7名 2009

[雑誌論文] Diabetes pattern on the 75g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus

Konishi I, Hiasa Y, Shigematsu S, 他7名, 2番目 2009

[雑誌論文] Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

Tanaka Y, Nishida N, Hiasa Y, 他26名, 18番目 2009

[雑誌論文] Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patients

Hiraoka A, Michitaka K, Hiasa Y, 他16名 2009

[学会発表] Decrease of SOCS-3 by ME3738 contributes to its synergistic anti-HCV effects when combined with type I interferon

Hiasa Y, Tokumoto Y, Konishi I, 他4名, 1番目 2009

[雑誌論文] Hepatocellular carcinoma for the non-specialist

Kumagi T, Hiasa Y, Hirschfield GM 2009

SEP (splenic elasticity for portal hypertension) score

SEP(splenic elasticity for portal hypertension) score