トップ›研究者を探す›心筋細胞内アセチルコリン産生系のエネルギー代謝調節と病態への関与の可能性

心筋細胞内アセチルコリン産生系のエネルギー代謝調節と病態への関与の可能性

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21590283
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
薬理学一般
研究機関 高知大学
代表研究者 柿沼 由彦
連携研究者 佐藤 隆幸
連携研究者 有川 幹彦
連携研究者 野口 達哉
連携研究者 鄭 燦
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額（履歴） 2011年度：780,000 (直接経費 :600,000、間接経費 :180,000)
2010年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2009年度：2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
キーワード 心血管
血液
アセチルコリン
心臓
エネルギー代謝
酸素消費量
ミトコンドリア
心筋細胞

研究成果

[学会発表] Donepezil, an Acetylcholinesterase Inhibitor, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice

Arikawa M, Kakinuma Y, et al 2012

[学会発表] Donepezil prevents cardiac rupture during acute phase of myocardial infarction in mice

Arikawa M, KakinumaY, Noguchi T, Sato T 2012

[学会発表] Donepezil, an Acetylcholinesterase Inhibitor, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice

Arikawa M, Kakinuma Y, Noguchi T, Yamasaki F, Satoh T 2012

[学会発表] Donepezil prevents cardiac rupture during acute phase of myocardial infarction in mice

Arikawa M, Kakinuma Y, Noguchi T, Sato T 2012

[学会発表] A non-neuronal cardiac cholinergic system(nNCCS) in cardiomyocytes plays a role in suppressing overshooting energy metabolism

Kakinuma Y, Akiyama T, Sato T 2012

[学会発表] A non-neuronal cardiac cholinergic System(nNCCS) in cardiomyocytes plays a role in suppressing overshooting energy metabolism

Kakinuma Y, Akiyama T, Sato T 2012

[雑誌論文] Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice

Arikawa M, Kakinuma Y, et al 2011

[学会発表] Acetylcholinesterase Inhibitor Donepezil in Treatment of Myocardial Ischemia and Heart Failure

Arikawa M, Kakinuma Y, Noguchi T, Sato T 2011

[学会発表] 心筋細胞内アセチルコリン産生系の生物学的意義

柿沼由彦, 秋山剛, 有川幹彦, 岡崎佳代, 佐藤隆幸 2011

[学会発表] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9の産生を抑制することにより急性期心破裂の危険率を低減する

有川幹彦, 柿沼由彦, 他 2011

[学会発表] 心筋細胞内アセチルコリン産生系の生物学的意義

柿沼由彦,秋山剛,有川幹彦,岡崎佳代,佐藤隆幸 2011

[学会発表] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9産生を抑制し急性期心破裂の危険率を低減する

有川幹彦, 柿沼由彦, 野口達哉, 佐藤隆幸 2011

[雑誌論文] Donepezil, Anti-Alzheimer' s Disease Drug, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice

Arikawa M, Kakinuma Y, Handa T, Yamasaki F, Sato T 2011

[学会発表] Acetylcholinesterase Inhibitor Donepezil in Treatment of Myocardial Ischemia and Heart Failure

Arikawa M, Kakinuma Y, Noguchi T, Sato T 2011

[学会発表] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9の産生を抑制することにより急性期心破裂の危険率を低減する

有川幹彦、柿沼由彦、野口達哉、佐藤隆幸 2011

[学会発表] ドネペジルはマウス心筋梗塞モデルにおいて、マクロファージMMP-9産生を抑制し急性期心破裂の危険率を低減する

有川幹彦,柿沼由彦,野口達哉,佐藤隆幸 2011

[学会発表] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy

Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H 2011

[学会発表] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy

Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H 2011

[雑誌論文] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy

Morita T, Kakinuma Y, et al 2011

[雑誌論文] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy

Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H 2011

[学会発表] Beneficial Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Heart Failure

Kubo T, Kitaoka H, Kakinuma Y, Satoh T, Doi Y 2011

[学会発表] Beneficial Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Heart Failure

Kubo T, Kitaoka H, Kakinuma Y, Sato T, Doi Y 2011

[雑誌論文] Donepezil, an acetylcholinesterase inhibitor against Alzheimer' s dementia, promotes angiogenesis in an ischemic hindlimb model

Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T 2010

[学会発表] Donepezil, an acetylcholinesterase inhibitor, reduces the risk of left ventricular free wall rapture during an acute phase of myocardial infarction by attenuating macrophage matrix metalloproteinase-9.

Arikawa M 2010

[学会発表] Effects of a non-neuronal cholinergic system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism

Kakinuma Y, Akiyama T, Arikawa M, Sato T 2010

[学会発表] Donepezil, an acetylcholinesterase inhibitor, reduces the risk of left ventricular free wall rapture during an acute phase of myocardial infarction by attenuating macrophage matrix metalloproteinase-9

Arikawa M, Kakinuma Y, Yamasaki F, Sato T 2010

[学会発表] Effects of a non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism

Kakinuma Y, Akiyama T, Arikawa M, Handa T, Sato T 2010

[学会発表] Effects of a non-central and non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism

Kakinuma Y, Akiyama T, Arikawa M, Handa T, Sato T 2010

[雑誌論文] Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury

Katare RG, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, Sato T 2010

[学会発表] 塩酸ドネペジル内服による心血管系への影響に関する前向き登録調査研究

久保亨、西永正典、柿沼由彦、佐藤隆幸、土居義典 2010

[学会発表] The new era of therapeutic modalities against heart failure, focusing on pharmacological intervention of the cardiovascular cholinergic system

Kakinuma Y, Sato T 2010

[雑誌論文] Engineered heart tissue : a novel tool to study the ischemic changes of the heart in vitro

Katare RG, Ando M, Kakinuma Y, Sato T 2010

[雑誌論文] Donepezilを使用した容量負荷心不全マウスにおける心機能改善効果

半田武巳、Katare GR、柿沼由彦、有川幹彦、安藤元規、山崎文靖、佐藤隆幸、篠栗志朗 2009

[雑誌論文] Anti-Alzheimer' s drug, donepezil, markedly improves long-term survival after chronic heart failure in mice

Handa T, Katare RG, Kakinuma Y, Arikawa M, Ando M, Sasaguri S, Yamasaki F, Sato T 2009

[雑誌論文] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect

Katare GR, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T 2009

[雑誌論文] Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/ VEGF/ PI3K signaling pathway

Katare GR, Kakinuma Y, Arikawa M, Yamasaki F, Sato T 2009

[学会発表] Donepezil, an Acetylcholinesterase Inhibitor Against Alzheimers Dementia, Prevents Remodeling in Volume-Overload Heart Failure Mice : Local and Central effect of Donepezil

Handa T, Sato T, Kakinuma Y, Arikawa M, Sasaguri S 2009

[学会発表] VHL遺伝子不活性化によるマウス虚血再潅流障害の抑制

森田拓、井口みつこ、柿沼由彦、倉林睦、藤枝幹也、脇口宏、執印太郎、佐藤隆幸、降幡睦夫 2009

[雑誌論文] Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium

Kakinuma Y, Akiyama T, Sato T 2009