トップ›研究者を探す›マラリア原虫メロゾイト先端部小器官分子に対するヒト赤血球レセプターの網羅的同定

マラリア原虫メロゾイト先端部小器官分子に対するヒト赤血球レセプターの網羅的同定

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-21249028
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
基礎医学
寄生虫学(含衛生動物学)
研究機関 愛媛大学
代表研究者 坪井 敬文
研究分担者 竹尾 暁
研究分担者 澤崎 達也
研究分担者 大槻 均
研究期間 開始年月日 2009/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 48,230,000 (直接経費 :37,100,000、間接経費 :11,130,000)
配分額（履歴） 2011年度：13,910,000 (直接経費 :10,700,000、間接経費 :3,210,000)
2010年度：13,910,000 (直接経費 :10,700,000、間接経費 :3,210,000)
2009年度：20,410,000 (直接経費 :15,700,000、間接経費 :4,710,000)
キーワード マラリア
レセプター
コムギ胚芽無細胞タンパク質合成系
ゲノム
感染症
バイオテクノロジー

研究成果

[雑誌論文] Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoite invasion into human erythrocytes

Sakamoto H, Takeo S, Maier AG, Sattabongkot J, Cowman AF, Tsuboi T 2012

[学会発表] Two post-genome approaches for the discovery of novel malaria blood-stage vaccine candidates using wheat germ cell-free system

Tsuboi T 2012

[雑誌論文] Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate

Tachibana M, Sato C, Otsuki H, Sattabongkot J, Kaneko O, Torii M, Tsuboi T 2012

[学会発表] Post-genome discovery of novel malaria vaccine candidates using wheat germ cell-free system

Tsuboi T 2011

[雑誌論文] Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen

Arumugam TU, Takeo S, Tsuboi T., 他14名 2011

[雑誌論文] A Plant-Produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum

Farrance CE, Rhee A, Tsuboi T., 他13名 2011

[雑誌論文] N-terminal pro-domain of Pfs230 synthesized using cell-free system is sufficient to induce the complement dependent malaria transmission-blocking activity

Tachibana M, Wu Y, Iriko H, Muratova O, Macdonald NJ, Sattabongkot J, Takeo S, Otsuki H, Torii M, Tsuboi T 2011

[雑誌論文] Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax.

Doi M, Tanabe K, Tsuboi T., 他14名 2011

[雑誌論文] Plasmodium vivax : comparison of immunogenicity among proteins expressed in the cell-free systems of Escherichia coli and wheat germ by suspension array assays

Rui E, Takeo S, Tsuboi T., 他4名 2011

[雑誌論文] Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine

Miyata T, Harakuni T, Tsuboi T., 他6名 2011

[雑誌論文] Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body

Ito D, Han ET, Takeo S, Thongkukiatkul A, Otsuki H, Torii M, Tsuboi T 2011

[雑誌論文] Tricomponent immunopotentiating system(TIPS) as a novel molecular design strategy for malaria vaccine development

Miyata T, Harakuni T, Tsuboi T., 他6名 2011

[雑誌論文] Measurement of naturally acquired humoral immune responses against the C-terminal region of the Plasmodium vivax MSP1 protein using protein arrays

Chen JH, Takeo S, Tsuboi T, Han ET., 他6名 2011

[学会発表] Post-genome discovery of novel malaria vaccine candidates using wheat germ cell-free system

Tsuboi T 2011

[雑誌論文] An efficient approach to the production of vaccines against the malaria parasite

Tsuboi T, Takeo S, Sawasaki T, Torii M, Endo Y 2010

[雑誌論文] The wheat germ cell-free protein synthesis system : a key tool for novel malaria vaccine candidate discovery

Tsuboi T, Takeo S, Arumugam TU, Otsuki H, Torii M 2010

[雑誌論文] The wheat germ cell-free protein synthesis system : a key tool for novel malaria vaccine candidate discovery

Tsuboi T 2010

[雑誌論文] Immunoproteomics profiling of blood stage Plasmodium vivax infection by high-throughput screening assays

Chen JH, Takeo S, Tsuboi T, Han ET., 他5名 2010

[学会発表] Wheat germ cell-free system-expressed Pfs230 is an effective transmission-blocking vaccine candidate antigen

Tsuboi T 2010

[学会発表] Sexual stage parasites and transmission-blocking antibodies

Tsuboi T 2010

[雑誌論文] Plasmodium vivax ookinete surface protein, Pvs25, linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization

Miyata T, Harakuni T, Tsuboi T., 他6名 2010

[雑誌論文] Intranasal and intramuscular immunization with baculovirus dual expression system-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission

Blagborough AM, Yoshida S, Sattabongkot J, Tsuboi T, Sinden RE 2010

[学会発表] Sexual stage parasites and transmission-blocking antibodies

Tsuboi T 2010

[雑誌論文] Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

VanBuskirk KM, Kangwanrangsan N, Tsuboi T, Cowman AF Kappe SHI., 他12名 2009

[雑誌論文] A small-scale systematic analysis of alternative splicing in Plasmodium falciparum

Iriko H, Jin L, Kaneko O, Takeo S, Han ET, Tachibana M, Otsuki H, Torii M, Tsuboi T 2009

[雑誌論文] Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast

Maeda T, Saito T, Harb OS, Roos DS, Takeo S, Suzuki H, Tsuboi T, Takeuchi T, Asai T 2009

[雑誌論文] Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence

Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M 2009

[雑誌論文] Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection

Arakawa T, Tachibana M, Torii M, Tsuboi T., 他7名 2009

[雑誌論文] Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine : comparison of heterologous prime boost strategies

Jiang G, Tsuboi T, Takeo S, Endo Y, Weiss WR., 他16名 2009

[雑誌論文] Evidence for the transmission of Plasmodium vivax in the Republic of the Congo, west central Africa

Culleton R, Takeo S, Tsuboi T, Tanabe K., 他6名 2009

[雑誌論文] Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites

Cao J, Kaneko O, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M 2009

[雑誌論文] Enzymatic characterization of the Plasmodium vivax chitinase, a potential malaria transmission-blocking target

Takeo S, Hisamori D, Matsuda S, Vinetz J, Sattabongkot J, Tsuboi T 2009

[雑誌論文] Wheat germ cell-free technology for accelerating the malaria vaccine research

Takeo S, Arumugam TU, Torii M, Tsuboi T 2009

[学会発表] Wheat germ cell-free protein synthesis system : a breakthrough for the post-genome malaria vaccine candidate discovery

Tsuboi T 2009