研究成果

[雑誌論文] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.

Suzuki A., Iwamura C., Shinoda K., Tumes JD., Kimura YM., Hosokawa H., Endo Y., Horiuchi S,, Tokoyoda K., Koseki H., Yamashita M., Nakayama T. 2010

[学会発表] TGFβ存在下においてIL-4はTh1細胞分化を増強する

東福寺聡一、中山俊憲、山下政克 2010

[学会発表] STAT6によって誘導されるポリコームとトライソラックスの置換反応

小野寺淳、山下政克、遠藤裕介、桑原誠、東福寺聡一、細川裕之、堀内周、渡邊友紀子、金井明教、鈴木譲、中山俊憲 2010

[学会発表] Sox4はTGFβ刺激で誘導され、GATA3機能の阻害を介してTh2細胞分化を抑制する

桑原誠、山下政克、東福寺聡一、鈴木淳平、篠田健太、中山俊憲 2010

[学会発表] Sox4によるTh1細胞分化制御の解析

東福寺聡一、桑原誠、鈴木淳平、小原収、中山俊憲、山下政克 2010

[学会発表] 新規チオアミド系化合物SH-2251はTh2細胞分化に伴うIL-5遺伝子座のクロマチンリモデリングを阻害する

鈴木淳平、東福寺聡一、桑原誠、今村匡志、中山俊憲、小原収、加藤文法、山下政克 2010

[雑誌論文] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.

Onodera A., Yamashita M., Endo Y., Kuwahara M., Tofukuji S., Hosokawa H., Kanai A., Suzuki Y., Nakayama T. 2010

[雑誌論文] The TCR-mediated signaling pathways that control the direction of helper T cell differentiation.

Nakayama T, Yamashita M 2010

[学会発表] Transcription factor MLL regulates IL-4-mediated anti-tumor response by tumor specific memory Th2 cells

Hosokawa H., Kitajima M., Ito T., Horiuchi S., Sasaki T., Nishimura T., Yamashita M., Nakayama T. 2009

[学会発表] Apolipoprotein A-II protects from ConcanavlinA-induced hepatitis through the inhibition of CD4 T cell activation.

山下潤二 2009

[学会発表] Regulation of GATA3-induced immune responses by the transcription factor Sox4.

山下政克 2009

[雑誌論文] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.

Nakayama T., Yamashita M. 2009

[雑誌論文] Bmil regulates memory Th cell survival via repression of the Noxa gene

Yamashita, M. 2009

[雑誌論文] CD69 controls the pathogenesis of allergic airway inflammation.

Miki HT., Hasegawa A., Iwamura C., Shinoda K, Tofukuji S., Watanabe Y., Hosokawa H., Motohashi S., Hashimoto K., Shirai M., Yamashita M., Nakayama T. 2009

[学会発表] Regulation of GATA3-induced immune responses by the transcription factor Sox4.

山下政克 2009

[学会発表] Regulation of GATA3-induced immune responses by the transcription factor Sox4

山下政克、桑原誠、東福寺聡一、中山俊憲 2009

[雑誌論文] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.

Kitajima M., Iwamura C., Miki HT., Shinoda K., Endo Y. Watanabe Y., Shinnakasu R., Hosokawa H., Hashimoto K., Motohashi S., Koseki H., Ohara O., Yamashita M., Nakayama T. 2009

[学会発表] Sox4 regulates GATA3-induced Th2 cell differentiation and Th2-dependent inflammatory responses

Kuwahara M., Yamashita M., Tofukuji S., Shinoda K., Onodera A., Suzuki J., Iwamura C., Nakayama T. 2009

[学会発表] GfilはGATA3蛋白質の安定化を介してTh2細胞分化を制御する

山下政克 2008

[雑誌論文] Initiation and maintenance of Th2 cell identity. Truncated title : Regulation of Th2 responses.

Nakayama T., Yamashita M. 2008

[図書] 免疫研究最前線2007

山下政克 2008

[雑誌論文] Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells.

Hossain MB., Hosokawa H., Hasegawa A., Watarai H., Taniguchi M., Yamashita M., Nakayama T. 2008

[雑誌論文] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness.

Hirahara K., Yamashita M., Iwamura C., Shinoda K., Hasegawa A., Yoshizawa H., Koseki H., Gejyo F., Nakayama T. 2008

[雑誌論文] Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function.

Yamashita, M. 2008

[雑誌論文] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.

Yamashita M., Kuwahara M., Suzuki A., Hirahara K., Shinnakasu R., Hosokawa H., Hasegawa A., Motohashi S., Iwama A., Nakayama T. 2008

[雑誌論文] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.

Shinnakasu R., Yamashita M., Kuwahara M., Hosokawa H., Hasegawa A., Motohashi S., Nakayama, T. 2008

[学会発表] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の存在を制御する/Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.

Yamashita, M. 2008

[雑誌論文] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.

Yamashita, M. 2008

[雑誌論文] Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.

Ito T., Hasegawa A., Hosokawa H., Yamashita M., Motohashi S., Naka T., Okamoto Y., Fujita,Y., Ishii Y., Taniguchi M., Yano I., Nakayama T. 2008

[学会発表] GfilはGATA3蛋白質の安定化を介してTh2細胞分化を制御する

山下政克 2008