トップ研究者を探す四大原子反応剤の不斉反応の開拓と生理活性有機化合物の不斉合成への展開

四大原子反応剤の不斉反応の開拓と生理活性有機化合物の不斉合成への展開

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-20249002
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
薬学
化学系薬学
研究機関 同志社女子大学
京都大学
代表研究者 富岡 清
連携研究者 山田 健一
連携研究者 山本 康友
研究期間 開始年月日 2008/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額(合計) 37,960,000 (直接経費 :29,200,000、間接経費 :8,760,000)
配分額(履歴) 2011年度:13,910,000 (直接経費 :10,700,000、間接経費 :3,210,000)
2010年度:13,260,000 (直接経費 :10,200,000、間接経費 :3,060,000)
2009年度:10,790,000 (直接経費 :8,300,000、間接経費 :2,490,000)
キーワード 四大元素
キラル配位子
不斉触媒
天然物合成
連続反応

研究成果

[雑誌論文] High Performance of N-Alkoxycarbonyl-Imines in Triethylborane-Mediated Tin-Free Radical Addition

Kiyoshi Tomioka 2012

[雑誌論文] Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane

Hao, X.; Chen, Q.; Kuriyama, M.; Yamada, K.; Yamamoto, Y.; Tomioka, K 2011

[雑誌論文] Chiral N-Heterocyclic Carbene. Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides : Steric and Electronic Effects on γ-Selectivity

Selim, K. B.; Nakanishi, H.; Matsumoto, Y.; Yamamoto, Y.; Yamada, K.; Tomioka, K 2011

[雑誌論文] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation

Hao, X.; Chen, Q.; Yamada, K.; Yamamoto, Y.; Tomioka, K 2011

[雑誌論文] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation

Kiyoshi Tomioka 2011

[雑誌論文] Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines

Akindele, T.; Yamada, K.; Sejima, T.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Tomioka, K 2010

[雑誌論文] Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1, 6-Enynes

Matsumoto, Y.; Selim, K. B.; Nakanishi, H.; Yamada, K.; Yamamoto, Y.; Tomioka, K 2010

[雑誌論文] Stereoselective Formal Synthesis of (+)-Allokainic Acid <i>via</i> Thiol-Mediated Acyl Radical Cyclization

Yamada, K.; Sato, T.; Hosoi, M.; Yamamoto, Y.; Tomioka, K 2010

[雑誌論文] Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines.

Xinyu Hao, Masami Kuriyama, Qian Chen, Yasutomo Yamamoto, Ken-ichi Yamada, Kiyoshi Tomioka 2009

[雑誌論文] Dimethylzinc Initiated Radical Reactions

Akindele, T, Yamada, K.; Tomioka, K 2009

[雑誌論文] Total Synthesis of (-)-Lycorine and(-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade.

Ken-ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, Kiyoshi Tomioka 2009

[雑誌論文] Total Synthesis of(-)-Lycorine and (-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade

Yamada, K.; Yamashita, M.; Sumiyoshi, T.; Nishimura, K.; Tomioka, K 2009

[雑誌論文] Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids

Chen, Q.; Kuriyama, M.; Hao, X.; Soeta, T.; Yamamoto, Y.; Yamada, K.; Tomioka, K 2009

[雑誌論文] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents.

Khalid B.Selim, Yasumasa Matsumoto, Ken-ichi Yamada, Kiyoshi Tomioka 2009

[雑誌論文] Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine

Mohamed, M. A, Yamada, K.; Tomioka, K 2009

[雑誌論文] Tandem Conjugate Addition-Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc

Yamada, K.; Maekawa, M.; Akindele, T.; Yamamoto, Y.; Nakano, M.; Tomioka, K 2009

[雑誌論文] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents

Selim, K. B, Matsumoto, Y.; Yamada, K.; Tomioka, K 2009

[雑誌論文] Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines

Hao, X.; Kuriyama, M.; Chen, Q.; Yamamoto, Y.; Yamada, K.; Tomioka, K 2009

[雑誌論文] Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates

Yamada, K.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Akindele, T.; Tomioka, K 2009

[雑誌論文] Chemoselective Conjugate Addition of Dimethylzinc-Mediated Ether and Acetal Radicals to Alkylidenemalonates and Asymmetric Reactions

Yamada, K.; Maekawa, M.; Akindele, T.; Nakano, M.; Yamamoto, Y.; Tomioka, K 2008

[雑誌論文] Copper-Catalyzed Asymmetric Allylic Substitution with Aryl and Ethyl Grignard Reagents

Selim, K. B.; Yamada, K.; Tomioka, K. 2008