トップ研究者を探す術後排尿障害モデルにおける脂肪由来幹細胞制御による神経再生促進効果に関する研究

術後排尿障害モデルにおける脂肪由来幹細胞制御による神経再生促進効果に関する研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19K09072
研究種目 基盤研究(C)
研究分野
研究機関 徳島大学
代表研究者 徳永 卓哉
研究分担者 柏原 秀也
研究分担者 齋藤 裕
研究分担者 西 正暁
研究分担者 吉川 幸造
研究期間 開始年月日 2019/4/1
研究期間 終了年度 2021
研究ステータス 完了 (2021/4/1)
配分額(合計) 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額(履歴) 2021年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2020年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2019年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード 神経再生
術後排尿障害
ADSC
HMGB1
脂肪由来幹細胞
Schwann細胞
排尿障害
mTORC1
HGGB1

研究成果

[雑誌論文] Strategy for laparoscopic repair of inguinal hernia after robot-assisted radical prostatectomy.

Eto S, Yoshikawa K, Yoshimoto T, Takasu C, Kashihara H, Nishi M, Tokunaga T, Nakao T, Higashijima J, Iwata T, Shimada M. 2022

[雑誌論文] Epigallocatechin-gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer-associated fibroblasts.

Chen S, Nishi M, Morine Y, Shimada M, Tokunaga T, Kashihara H, Takasu C, Yamada S, Wada Y. 2022

[雑誌論文] Usefulness of a stepwise training program for laparoscopic gastrectomy.

Nishi M, Shimada M, Yoshikawa K, Tokunaga T, Kashihara H, Takasu C, Yoshimoto T, Iwahashi S. 2022

[雑誌論文] Propensity Score-Matched Analysis of the Short- and Long-Term Outcomes of Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer

Nishi M, Shimada M, Yoshikawa K, Takasu C, Wada Y, Tokunaga T, Nakao T, Kashihara H, Yoshimoto T, Yamashita S. 2022

[雑誌論文] The correlation of immunoscore and frailty in colorectal cancer.

Nakao T, Shimada M, Yoshikawa K, Tokunaga T, Nishi M, Kashihara H, Takasu C, Wada Y, Yoshimoto T, Yamashita S, Iwakawa Y. 2022

[雑誌論文] Usefulness of Diagnostic Staging Laparoscopy for Advanced Gastric Cancer.

Yoshikawa K, Shimada M, Higashijima J, Tokunaga T, Nishi M, Takasu C, Kashihara H, Eto S, Yoshimoto T. 2021

[雑誌論文] The influence and countermeasure of obesity in laparoscopic colorectal resection.

Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Tokunaga T, Nishi M, Takasu C, Yoshimoto T. 2021

[雑誌論文] A Transabdominal Robotic Purse-String Suture Technique for Transanal Total Mesorectal Excision.

Tokunaga T, Kashihara H, Higashijima J, Yoshikawa K, Nishi M, Takasu C, Eto S, Yoshimoto T, Shimada M. 2021

[雑誌論文] High Ligation of the Inferior Mesenteric Artery Induces Hypoperfusion of the Sigmoid Colon Stump During Anterior Resection.

Higashijima J, Kono T, Shimada M, Sugitani A, Kashihara H, Takasu C, Nishi M, Tokunaga T, Yoshikawa K. 2021

[雑誌論文] Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer.

Nishi M, Shimada M, Tokunaga T, Higashijima J, Yoshikawa K, Kashihara H, Takasu C, Ishikawa D, Wada Y, Eto S, Yoshimoto T. 2021

[雑誌論文] The role of the immunoescape in colorectal cancer liver metastasis.

Takasu C, Yamashita S, Morine Y, Yoshikawa K, Tokunaga T, Nishi M, Kashihara H, Yoshimoto T, Shimada M. 2021

[雑誌論文] Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery.

Yamashita S, Nishi M, Ikemoto T, Yoshikawa K, Higashijima J, Tokunaga T, Takasu C, Kashihara H, Eto S, Yoshimoto T, Shimada M. 2021

[雑誌論文] Robotic-assisted total gastrectomy in a patient with gastric cancer associated with situs inversus totalis: With video.

Yoshimoto T, Yoshikawa K, Tokunaga T, Nishi M, Takasu C, Kashihara H, Nakasu C, Shimada M. 2021

[雑誌論文] Effect of TU-100 on Peyer's patches in a bacterial translocation rat model.

Takasu C, Miyazaki K, Yoshikawa K, Nishi M, Tokunaga T, Kashihara H, Yoshimoto T, Ogawa H, Morine Y, Shimada M. 2021

[学会発表] 直腸切断術に対するTransperineal approachの有用性

徳永 卓哉 2021

[学会発表] 当科におけるTaTME手術手技と治療成績

徳永 卓哉 2021

[学会発表] TaTMEの手術手技と治療成績

徳永 卓哉 2021

[学会発表] 他臓器合併切除を要する直腸癌に対するTrasaperineal abdominoperineal resection

徳永 卓哉 2021

[学会発表] 直腸癌に対する経肛門的アプローチにおけるホログラムと尿道造影を併用した術中ナビゲーション

徳永 卓哉 2021

[学会発表] ホログラムと術中尿道造影を駆使した経会陰的直腸切断術(TpAPR)

徳永 卓哉 2021

[学会発表] 直腸切断術TpTMEにおける術前VR・MRシミュレーションと術中尿道造影ナビゲーションの有用性

徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 齋藤裕, 柏原秀也, 高須千絵, 良元俊昭, 武原悠花子, 杉本真樹 2020

[雑誌論文] Impact of sidedness of colorectal cancer on tumor immunity.

Takasu C, Nishi M, Yoshikawa K, Tokunaga T, Kashihara H, Yoshimoto T, Shimada M. 2020

[学会発表] TpTMEにおける前壁側剥離の工夫 ~術中尿道造影の有用性~

徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 高須千絵, 吉川雅登, 良元俊昭, 武原悠花子 2020

[雑誌論文] Intraoperative Thermal Imaging for Evaluating Blood Perfusion During Laparoscopic Colorectal Surgery.

Tokunaga T, Shimada M, Higashijima J, Yoshikawa K, Nishi M, Kashihara H, Takasu C, Ishikawa D, Yoshimoto T. 2020

[学会発表] 術中尿道造影を併用したTpAPR手術手技

徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 高須千絵, 江藤祥平, 良元俊昭 2020

[雑誌論文] Usefulness of an ICG fluorescence catheter system in TaTME for avoiding intraoperative urethral injury

Ohta S, Nishi M, Tokunaga T, Yoshikawa K, Higashijima J, Miyatani T, Kashihara H, Takasu C, Ishikawa D, Shimada M. 2020

[雑誌論文] Trans-abdominal Pre-peritoneal (TAPP) Inguinal Hernia Repair with Liquid-injection and Gauze Dissection

Kashihara H, Shimada M, Yoshikawa K, Miyatani T, Tokunaga T, Nishi M, Takasu C, Yoshimoto T. 2020

[雑誌論文] The usefulness of intraoperative X-ray fluoroscopy in avoiding urethral injury during transanal total mesorectal excision.

Tokunaga T, Higashijima J, Yoshikawa K, Nishi M, Kashihara H, Takasu C, Shimada M. 2020

[雑誌論文] Establishment of an evaluation system for non-technical skills in surgery : Surgeon and paramedical staff assessments

Yoshikawa K, Shimada M, Higashijima J, Miyatani T, Tokunaga T, Nishi M, Takasu C, Kashihara H, Yoshimoto T, Iwata T. 2020

[学会発表] 経会陰的全直腸間膜切除術(TpTME)のピットフォール~術中尿道損傷の有用性~

Tokunaga T, Shimada M, Higashijima J, Yoshikawa K, Nishi M, Kashihara H, Takasu C, Eto S, Yoshimoto T 2020

[雑誌論文] Transoral Anvil Delivery System With Tension-Free Method for Esophagojejunostomy After Laparoscopic Total Gastrectomy Prevents The Postoperative Stenosis.

Yoshikawa K, Shimada M, Higashijima J, Tokunaga T, Nishi M, Takasu C, Kashihara H, Eto S, Yoshimoto T. 2020

[雑誌論文] Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab.

Yoshimoto T, Yoshikawa K, Higashijima J, Miyatani T, Tokunaga T, Nishi M, Takasu C, Kashihara H, Takehara Y, Shimada M. 2020

[学会発表] TpTMEを安全に行うために ~前壁剥離時の術中尿道造影の有用性~

徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 高須千絵, 良元俊昭, 武原悠花子 2019

[学会発表] Urethrography navigationを用いたTpTME手術手技

徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 2019

[学会発表] 直腸切断術におけるTaTMEの工夫~尿道損傷回避のための術中尿道造影の有用性~

徳永 卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 高須千絵, 良元俊昭 2019

[雑誌論文] Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons

Nishi Masaaki、Yoshikawa Kozo、Higashijima Jun、Tokunaga Takuya、Takasu Chie、Kashihara Hideya、Ishikawa Daichi、Shimada Mitsuo 2019

[雑誌論文] The Effect of Laparoscopic Sleeve Gastrectomy on Obesity and Obesity-related Disease : the Results of 10 Initial Cases

Kashihara Hideya、Shimada Mitsuo、Yoshikawa Kozo、Higashijima Jun、Miyatani Tomohiko、Tokunaga Takuya、Nishi Masaaki、Takasu Chie、Hamada Yasuhiro 2019

[雑誌論文] Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation.

Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Miyatani T, Tokunaga T, Nishi M, Takasu C. 2019

[雑誌論文] The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer

ISHIKAWA DAICHI、TAKASU CHIE、KASHIHARA HIDEYA、NISHI MASAAKI、TOKUNAGA TAKUYA、HIGASHIJIMA JUN、YOSHIKAWA KOZO、YASUTOMO KOJI、SHIMADA MITSUO 2019

[学会発表] The Usefulness of Intraoperative X-ray Fluoroscopy for Avoiding Urethral Injury in Transperineal total Mesorectal Excision

Tokunaga T, Yoshikawa K, Miyatani T, Nishi M, Kashihara H, Takasu C, Yoshimoto T, Takehara Y, Shimada M 2019

[雑誌論文] Usefulness of blood flow evaluation by indocyanine green fluorescence system in laparoscopic anterior resection.

Higashijima Jun、Shimada Mitsuo、Yoshikawa Kozo、Miyatani Tomohiko、Tokunaga Takuya、Nishi Masaaki、Kashihara Hideya、Takasu Chie 2019