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徳永卓哉

徳島大学

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2024年11月15日更新

職名: 特任講師
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学位: 博士(医学)
職歴・経歴: 2013/4: 徳島大学特任助教, 病院 (-2017.3.)
2017/4: 徳島大学助教, 病院 (-2021.3.)
2021/4: 徳島大学特任准教授, 病院 (-2023.1.)
2023/2: 徳島大学助教, 病院 (-2024.3.)
2024/4: 徳島大学特任教授, 病院

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2024年11月15日更新

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2024年11月15日更新

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沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period,
Scientific Reports, Vol.13, No.1, 1856-1856, 2023年.

(要約): <jats:title>Abstract</jats:title><jats:p>Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.</jats:p>
(キーワード): Multidisciplinary
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-28923-3
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1360580230617360512; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-28923-3

(DOI: 10.1038/s41598-023-28923-3, CiNii: 1360580230617360512) Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period.,
Scientific Reports, Vol.13, No.1, 1856, 2023.

(要約): Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
(キーワード): Rats / Animals / Jejunum / Diabetes Mellitus, Type 2 / Positron Emission Tomography Computed Tomography / Fluorodeoxyglucose F18 / Duodenum / Glucose / Glucose Transport Proteins, Facilitative / Blood Glucose / Gastric Bypass
(徳島大学機関リポジトリ): ● Metadata: 118744
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-28923-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36726038; ● Search Scopus @ Elsevier (PMID): 36726038; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-28923-3

(徳島大学機関リポジトリ: 118744, DOI: 10.1038/s41598-023-28923-3, PubMed: 36726038) Yosuke Iwakawa, Kouzou Yoshikawa, Koichi Okamoto, Tetsuji Takayama, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita and Mitsuo Shimada :
Four cases of gastric adenocarcinoma and proximal polyposis of the stomach treated by robotic total gastrectomy,
Surgical Case Reports, Vol.8, No.1, 70, 2022.

(要約): Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare disease and characterized by a unique point mutation in the promoter 1B region of the adenomatous polyposis coli (APC) gene. There are two aims in surgery for GAPPS; the first is prophylactic gastrectomy, and the second is excising concurrent cancer. We performed robotic total gastrectomy (RTG) for four cases of GAPPS. Case 1 was a woman in her 40 s whose sister had died from gastric cancer. Mutational analysis revealed mutation of APC exon 1B. We performed prophylactic gastrectomy. Case 2 was a woman in her 30 s who had a mutation of APC exon 1B, and preoperative biopsy revealed suspected adenocarcinoma. Case 3 was a woman in her 40 s who was diagnosed with gastric cancer with multiple polyps in the stomach and a mutation of APC exon 1B. Case 4 was a woman in her 20 s in whom biopsy revealed low-grade dysplasia of a raised lesion. She had a mutation in APC exon 1B. We performed RTG with D1 + lymphadenectomy in all patients, and there were no intraoperative complications. Patients with GAPPS are mainly followed regularly with repeat biopsy, and tumors are detected in an early stage. As the safety of robotic surgery for the early gastric cancer is reported, RTG is an option for these patients. This is the first report of RTG for GAPPS patients.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40792-022-01425-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35435526; ● Search Scopus @ Elsevier (PMID): 35435526; ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-022-01425-6

(DOI: 10.1186/s40792-022-01425-6, PubMed: 35435526) Shoko Yamashita, Masaaki Nishi, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Yosuke Iwakawa, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada :
Gastric carcinoma with lymphoid stroma derived from hamartomatous inverted polyp with osteoclast-like giant cells: a case report.,
International Cancer Conference Journal, Vol.11, No.3, 196-200, 2022.

(要約): Gastric carcinomas with lymphoid stroma (GCLS) are characterized by prominent stromal infiltration of lymphocyte and account for 1-4% of gastric cancers. Although, osteoclast-like giant cells (OGC) have been reported in some GCLS, OGCs in gastric tumors is exceedingly rare. A 60-year-old woman presented to our hospital after the finding of a positive fecal blood test during a routine medical check. Esophagogastroduodenoscopy revealed a Type 0-III + IIc tumor in the middle part of the gastric body. Biopsy revealed a poorly differentiated tumor and she was referred to our department. Early phase computed tomography showed thickening of the wall in the middle of the gastric body and enlargement of nearby lymph nodes. Laparoscopic total gastrectomy was performed. Pathological examination revealed a hamartomatous inverted polyp (HIP) in the submucosal layer with tub2-por1 tumor in the HIP. Prominent lymphocytic infiltration and OGCs were found around the tumor. Immunohistochemical analysis showed that the tumor cells were negative for EBER, MLH-1, and MSH2, 6. These findings suggest that this tumor was a non-microsatellite instability (MSI)-high GCLS without Epstein-Barr virus (EBV) infection. The patient's postoperative course was uneventful and she was discharged 11 days after surgery. She remains well 3 years after surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s13691-022-00547-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35669900; ● Search Scopus @ Elsevier (PMID): 35669900; ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-022-00547-w

(DOI: 10.1007/s13691-022-00547-w, PubMed: 35669900) 佐々木雄太郎, 安宅真利花, 多田航生, 中西亮太, 橋本啓佑, 吉岡拓哉, 大豆本圭, 尾崎啓介, 上野恵輝, 津田恵, 楠原義人, 布川朋也, 山本恭代, 山口邦久, 高橋正幸, 金山博臣, 柏原秀也, 徳永卓哉 :
局所進行直腸癌に対してロボット支援骨盤内臓全摘除術および体腔内回腸導管造設術を施行した2例,
泌尿器科紀要, Vol.68, No.5, 155-159, 2021年.

(要約): We describe two cases of locally advanced rectal cancer (LARC) treated with robot-assisted total pelvic exenteration (Ra-TPE) and intracorporeal ileal conduit (ICIC). The first case was in a 71-year-old man with LARC (RbP, T4bN2bM0, cStage IIIc). He was started on bevacizumab+S-1/oxaliplatin therapy in July 2019. In April 2020, he developed Fournier's gangrene due to subcutaneous penetration of rectal cancer. Emergency drainage and colostomy were performed simultaneously, and a percutaneous vesical fistula was created. In May 2020, Ra-TPE and ICIC were performed. Histopathological analysis revealed moderately differentiated tubular adenocarcinoma (ypT3N0, RM0). At postoperative 9 months, thoracoscopic right upper lobectomy was performed for a right metastatic lung tumor. At present, ie, at postoperative 12 months, the patient has been free of recurrence and metastasis, with a carcinoembryonic antigen (CEA) level of 1.4 ng/ml and carcinoma antigen (CA) 19-9 level of 11 U/ml. The second case was in a 61-year-old man with fistula-associated anal cancer (PRb, T4N3M1b, cStage IVb). In April 2019, he was started on FOLFOXIRI+cetuximab therapy. In August 2020, Ra-TPE, ICIC, and transperineal total mesenteric excision were performed. Histopathological analysis revealed adenocarcinoma (ypT4N0, RM0). At postoperative 11 months, thoracoscopic left lower lobectomy was performed for a left metastatic lung tumor. At present, ie, at postoperative 12 months, the patient remains free of recurrence and metastasis, with a CEA level of 7.3 ng/ml and CA19-9 level of 12 U/ml. Ra-TPE, which allows transperineal removal of a specimen, can be performed as a minimally invasive surgery in combination with ICIC.
(キーワード): Robot-assisted total pelvic exenteration / Intracorporeal urinary diversion / Intracorporeal ileal conduit
(出版サイトへのリンク): ● Publication site (DOI): 10.14989/actauroljap_68_5_155
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390855656035011840; ● Search Scopus @ Elsevier (DOI): 10.14989/actauroljap_68_5_155

(DOI: 10.14989/actauroljap_68_5_155, CiNii: 1390855656035011840) Toshiaki Yoshimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara and Mitsuo Shimada :
Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab.,
Annals of Gastroenterological Surgery, Vol.4, No.2, 151-155, 2020.

(要約): The purposes of this study are to present cases of emergency surgery in which gastrointestinal perforation occurred during bevacizumab administration, consider the indications for emergency surgery, and examine the safety of scheduled surgery after a washout period for bevacizumab. (a) We retrospectively investigated seven patients who underwent emergency surgery for bevacizumab-associated intestinal perforation. (b) We investigated 104 patients with advanced colorectal cancer treated with neoadjuvant therapy who underwent surgery from 2008 to 2018, retrospectively. (a) In the seven patients undergoing emergency surgery for gastrointestinal perforation, the median bevacizumab administration and washout periods were 16 weeks and 24 days, respectively. A stoma was created in all patients except in those who were not candidates. Two patients developed postoperative abdominal abscesses, and two patients died from perioperative sepsis and gastrointestinal bleeding, respectively; both of these patients had poor performance status. (b) In patients receiving bevacizumab (n = 45) and patients treated with bevacizumab-free regimens as neoadjuvant therapy (n = 59), 31 and 52 patients received chemoradiotherapy, respectively. We found no correlation with postoperative complications with or without bevacizumab. The surgical indications should be considered carefully in patients with gastrointestinal perforation secondary to bevacizumab administration. Meanwhile, after appropriate cessation time, scheduled surgery following bevacizumab administration is feasible.
(徳島大学機関リポジトリ): ● Metadata: 116475
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ags3.12312
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32258980; ● Search Scopus @ Elsevier (PMID): 32258980; ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12312

(徳島大学機関リポジトリ: 116475, DOI: 10.1002/ags3.12312, PubMed: 32258980) Daichi Ishikawa, Kouzou Yoshikawa, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Jun Higashijima and Mitsuo Shimada :
Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer.,
Anticancer Research, Vol.40, No.1, 239-244, 2020.

(要約): In previous studies, we demonstrated the significant role of microRNA-449a (miR-449a) in colorectal cancer with in vivo and clinical samples. The importance of miR-449a in gastric cancer is still to be elucidated. This study examined the impact of miR-449a expression in tumor tissue and serum and investigated its potential as a prognostic marker in gastric cancer. Sixty-six patients with gastric cancer who underwent surgery were included in the study. miR-449a expression in tumor tissue and serum were investigated by real-time polymerase chain reaction analysis. The association of miR-449a expression with clinicopathological factors and patient prognosis were also investigated. miR-449a expression was lower in tumor tissue than non-tumor tissue. miR-449a in tumor tissue negatively correlated with the malignancy of tumor and clinical stage. Increased carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels were seen at significantly higher frequencies in patients with low miR-449a expression. Patients with low miR-449a expression had poorer cancer-specific survival compared to those with high miR-449a expression. The univariate analysis showed that lymphovascular invasion, increased CEA and CA19-9 and a low expression of miR-449a were associated with a poorer 5-year cancer-specific survival. miR-449a expression level in serum correlated to that in tumor tissue and was also associated with tumor malignancy. The miR-449a level in tumor tissue might be useful as a prognostic indicator for patients with gastric cancer and miR-449a in serum appears to reflect its expression in tumor tissue.
(キーワード): Aged / Disease-Free Survival / Female / Gene Expression Regulation, Neoplastic / Humans / Male / MicroRNAs / Prognosis / Stomach Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.13945
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31892572; ● Search Scopus @ Elsevier (PMID): 31892572; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13945

(DOI: 10.21873/anticanres.13945, PubMed: 31892572) Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Toshiaki Yoshimoto and Takashi Iwata :
Establishment of an evaluation system for non-technical skills in surgery : Surgeon and paramedical staff assessments.,
The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 83-86, 2020.

(要約): Purposes : Non-technical skills contribute to safe and efficient team performance. The aim of this study was to clarify the importance of non-technical skills by a questionnaire and the usefulness of feedback to the operator. Method : A questionnaire was administered to the operator and paramedical staff for 404 operations. Total and individual scores were compared, and the effect of feedback was analyzed by comparison between pre-feedback and post-feedback. Results : The total score of the paramedical staff was 100 [full score] [n = 186], 90-99 [n = 133], and 80-89 [n = 47]. In all cases, the score of the paramedical staff was significantly better than that of the operator. After feedback, the rate of a score less than 80 was significantly decreased. In junior doctor cases with laparoscopy, feedback tended to have a positive effect. Conclusions : Questionnaires completed by both surgeons and paramedical staff are useful for identifying problems with non-technical skills. J. Med. Invest. 67 : 83-86, February, 2020.
(キーワード): Allied Health Personnel / Clinical Competence / Communication / Decision Making / Evaluation Studies as Topic / General Surgery / Humans / Leadership / Patient Care Team / Surgeons / Surveys and Questionnaires
(徳島大学機関リポジトリ): ● Metadata: 114757
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.83
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378623; ● Search Scopus @ Elsevier (PMID): 32378623; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.83

(徳島大学機関リポジトリ: 114757, DOI: 10.2152/jmi.67.83, PubMed: 32378623) Daichi Ishikawa, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Koji Yasutomo and Mitsuo Shimada :
The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.,
Anticancer Research, Vol.39, No.6, 2855-2860, 2019.

(要約): miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression.
(キーワード): Aged / Antigens, Tumor-Associated, Carbohydrate / Colorectal Neoplasms / Female / Gene Expression Regulation, Neoplastic / Histone Deacetylase 1 / Humans / Liver Neoplasms / Male / MicroRNAs / Middle Aged / Neoplasm Invasiveness / Prognosis / Survival Analysis
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.13414
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31177123; ● Search Scopus @ Elsevier (PMID): 31177123; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13414

(DOI: 10.21873/anticanres.13414, PubMed: 31177123) Tumenjin Enkhbat, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Masahide Tominaga and Mitsuo Shimada :
Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy.,
Anticancer Research, Vol.38, No.11, 6247-6252, 2018.

(要約): Epigallocatechin-3-gallate (EGCG) is a major polyphenolic component of green tea. EGCG plays a potential role in radio-sensitizing cancer cells. The combined effect of EGCG and radiation was investigated in a colorectal cancer cell line, focusing on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) autophagy signalling. HCT-116 cells were treated with 12.5 μM EGCG for different periods of time, 2 Gy radiation, or both. Cell viability was determined with the WST-8 assay. The number of colonies was determined with the colony formation assay. mRNA expression of LC3 and caspase-9 was analyzed with quantitative real-time polymerase chain reaction. Combination treatment with EGCG and radiation significantly decreased the growth of HCT-116 cells. The number of colonies was reduced to 34.2% compared to the control group. Immunofluorescence microscopy images showed that nuclear translocation of Nrf2 was significantly increased when cells were treated with the combination of EGCG and radiation compared to the control and single-treatment groups. Combined treatment with EGCG and radiation significantly induced LC3 and caspase-9 mRNA expression. EGCG increased the sensitivity of colorectal cancer cells to radiation by inhibiting cell proliferation and inducing Nrf2 nuclear translocation and autophagy.
(キーワード): Caspase 9 / Catechin / Cell Nucleus / Cell Proliferation / Cell Survival / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / HCT116 Cells / Humans / Microtubule-Associated Proteins / NF-E2-Related Factor 2 / Protein Transport / Radiation-Sensitizing Agents / Transcriptional Activation
(徳島大学機関リポジトリ): ● Metadata: 113340
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12980
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30396944; ● Summary page in Scopus @ Elsevier: 2-s2.0-85056084372

(徳島大学機関リポジトリ: 113340, DOI: 10.21873/anticanres.12980, PubMed: 30396944, Elsevier: Scopus) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi and Chie Takasu :
The Effect of Roux-en-Y Reconstruction on Type 2 Diabetes in the Early Postoperative Period.,
Anticancer Research, Vol.38, No.8, 4901-4905, 2018.

(要約): The aim of this study was to investigate the effect of Roux-en-Y (RY) reconstruction on type 2 diabetes with gastric cancer in the early postoperative period. A total of 44 patients with gastric cancer with type 2 diabetes who underwent total gastrectomy (TG) or distal gastrectomy (DG) with Roux-en-Y reconstruction or DG with Bilroth I were enrolled. All three groups had their fasting glucose and daily insulin dose recorded preoperatively, on day 2 postoperatively (POD2) and at discharge. The TG group showed low fasting glucose and daily insulin dose on POD2 compared to their preoperative state. On discharge, the fasting glucose and daily insulin dose were significantly lower in both TG and DG Roux-en-Y groups than preoperatively. Roux-en-Y reconstruction showed early improvement of type 2 diabetes regardless of any body weight loss. The effect of Roux-en-Y reconstruction in TG on type 2 diabetes was more remarkable than that of DG.
(キーワード): Aged / Aged, 80 and over / Anastomosis, Roux-en-Y / Blood Glucose / Diabetes Mellitus, Type 2 / Female / Gastrectomy / Gastroenterostomy / Humans / Insulin / Male / Middle Aged / Postoperative Period / Stomach Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12805
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30061267; ● Search Scopus @ Elsevier (PMID): 30061267; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.12805

(DOI: 10.21873/anticanres.12805, PubMed: 30061267) Tumenjin Enkhbat, Masaaki Nishi, Chie Takasu, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada :
Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer.,
Anticancer Research, Vol.38, No.6, 3367-3373, 2018.

(要約): Programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1(PD-L1) axis is associated with immune tolerance via inhibition of T cell activation. The aim of this study was to clarify the significance of PD-1 and PD-L1 expressions and analyze the relationships between PD-1, PD-L1, transforming growth factor-β (TGF-β) and Forkhead box P3 (Foxp3) expressions in colorectal cancer (CRC). A total of 116 patients who underwent curative colectomy for stage II/III CRC were included in the study. PD-1, PD-L1, TGF-β, and Foxp3 expressions were examined by immunohistochemistry and related to prognostic factors by Kaplan-Meier. PD-1 expression was correlated with PD-L1, TGF-β, and Foxp3 expressions. Overall survival rates were significantly poorer in the PD-1 and PD-L1-positive groups. Multivariate analysis showed that PD-L1-positive is an independent risk factor. Disease-free survival (DFS) was tended in the PD-L1-positive group. The group with double-positive expression had significantly poorer prognosis. PD-1 and PD-L1 expressions were associated with a poor prognosis and correlated with TGF-β and Foxp3 expressions in patients with CRC.
(キーワード): Adult / Aged / Aged, 80 and over / B7-H1 Antigen / Colectomy / Colorectal Neoplasms / Female / Forkhead Transcription Factors / Humans / Immunohistochemistry / Kaplan-Meier Estimate / Male / Middle Aged / Prognosis / Programmed Cell Death 1 Receptor / Transforming Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12603
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848685; ● Summary page in Scopus @ Elsevier: 2-s2.0-85048247787

(DOI: 10.21873/anticanres.12603, PubMed: 29848685, Elsevier: Scopus) Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada and Mitsuo Shimada :
The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer.,
Anticancer Research, Vol.38, No.6, 3387-3392, 2018.

(要約): Indoleamine 2,3-dioxygenase (IDO) down-regulates T cell activation, attenuates regulatory T cell (Treg) activation and is related to immune tolerance. The aim of the study was to clarify the significance of IDO expression and analyze the relationships between the expression of IDO, TGF-β, and Foxp3 in gastric cancer (GC). A total of 60 patients who underwent curative gastrectomy for stage III gastric cancer were included in the study. The expression of IDO, TGF-β, and Foxp3 was examined by immunohistochemistry and the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. IDO expression was not positively correlated with any of the factors examined. IDO expression was positively correlated with TGF-β expression (p<0.05), and TGF-β expression was positively correlated with FoxP3 expression (p<0.05). Overall survival (OS) rates were significantly poorer in the IDO-positive group compared to the IDO-negative group (3-year OS, 78.5% vs. 90%, respectively; p<0.05). Multivariate analysis confirmed IDO expression as independent prognostic factors in OS. Disease-free survival (DFS) was significantly poorer in the IDO-positive group compared to the IDO-negative group (3-year DFS, 59.3% vs. 69.3%, respectively; p<0.05). IDO is associated with poor prognosis and immuno-tolerance through attenuation of Treg activation in Stage III GC.
(キーワード): Adult / Aged / Aged, 80 and over / Female / Forkhead Transcription Factors / Gastrectomy / Humans / Immunohistochemistry / Indoleamine-Pyrrole 2,3,-Dioxygenase / Kaplan-Meier Estimate / Male / Middle Aged / Multivariate Analysis / Neoplasm Staging / Prognosis / Stomach Neoplasms / T-Lymphocytes, Regulatory / Transforming Growth Factor beta1
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12605
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848687; ● Summary page in Scopus @ Elsevier: 2-s2.0-85048212303

(DOI: 10.21873/anticanres.12605, PubMed: 29848687, Elsevier: Scopus) Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara and Daichi Ishikawa :
Usefulness of the Transoral Anvil Delivery System for Esophagojejunostomy After Laparoscopic Total Gastrectomy: A Single-institution Comparative Study of Transoral Anvil Delivery System and the Overlap Method.,
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, Vol.28, No.2, e40-e43, 2018.

(要約): Many reconstruction techniques have been reported after laparoscopic total gastrectomy (LTG), but it is not clear which anastomosis technique is most useful, and no standard methods have been established. This study examined whether LTG using the transoral anvil delivery system (TOADS) is a feasible and safe procedure for gastric cancer. A series of 47 patients underwent the overlap method and 36 underwent the hemi-double-stapling technique with TOADS. Intraoperative and postoperative outcomes were compared between the 2 groups. In the TOADS group, operation time for reconstruction was shorter (16 3 vs. 45 10in, P=0.003), and blood loss was reduced (45 15 vs. 126 13L, P=0.0002). There were no significant differences in intraoperative complications, conversion to open surgery, and intraoperative anastomosis-related complications between the 2 groups. Furthermore, there were no significant differences in the incidence of complications, reoperation, mortality, and postoperative hospital stay. LTG using TOADS for gastric cancer may be a technically feasible surgical procedure with acceptable morbidity.
(キーワード): Adult / Aged / Aged, 80 and over / Esophagostomy / Female / Follow-Up Studies / Gastrectomy / Humans / Jejunostomy / Laparoscopy / Male / Middle Aged / Mouth / Natural Orifice Endoscopic Surgery / Operative Time / Postoperative Complications / Reoperation / Retrospective Studies / Stomach Neoplasms / Suture Techniques / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/SLE.0000000000000495
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29064880; ● Search Scopus @ Elsevier (PMID): 29064880; ● Search Scopus @ Elsevier (DOI): 10.1097/SLE.0000000000000495

(DOI: 10.1097/SLE.0000000000000495, PubMed: 29064880) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Ichio Suzuka, Takashi Nishizaki, Hiroshi Okitsu, Toshiyuki Yagi, Hidenori Miyake, Murato Miura, Mitsutoshi Fukuyama, Daisuke Wada and Yoshiaki Bando :
Propensity score-matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals.,
Journal of Gastroenterology and Hepatology, Vol.31, No.10, 1700-1704, 2016.

(要約): Various randomized clinical studies have suggested that short- and long-term outcomes of laparoscopic surgery (LAP) for colorectal cancer are comparable with those of open surgery (OP). However, these studies were performed in high-volume hospitals. The aim of the present study was to compare the outcomes of LAP versus OP for colorectal cancer in rural hospitals. This was a multicenter retrospective propensity score-matched case-control study of patients who underwent colorectal surgery from January 2004 to April 2009 in 10 hospitals in Japan. All patients underwent curative surgery for pathologically diagnosed stage II or III colorectal cancer. The primary end point was 5-year overall survival (OS). The secondary end points were disease-free survival (DFS) and postoperative complications. In total, 319 patients who underwent LAP and 1020 patients who underwent OP were balanced to 261 pairs. There was no significant difference in the OS and DFS between two groups. The operation time was significantly shorter for OP than for LAP. Blood loss was significantly lower in LAP than in OP. There was no difference in intraoperative morbidity between the two groups. The postoperative morbidity was significantly lower in LAP than in OP. The hospital stay was significantly shorter in LAP than in OP. There was no significant difference in 90-day postoperative mortality. Laparoscopic surgery may be a feasible option for colorectal cancer in rural hospitals.
(キーワード): Adult / Aged / Aged, 80 and over / Colectomy / Colorectal Neoplasms / Feasibility Studies / Female / Hospitals, Rural / Humans / Laparoscopy / Length of Stay / Male / Middle Aged / Neoplasm Grading / Neoplasm Staging / Propensity Score / Retrospective Studies / Survival Analysis / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/jgh.13322
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26896303; ● Summary page in Scopus @ Elsevier: 2-s2.0-85002156898

(DOI: 10.1111/jgh.13322, PubMed: 26896303, Elsevier: Scopus) Shohei Eto, Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Horohiko Sato and Nobuhiro Kurita :
The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer.,
Anticancer Research, Vol.35, No.4, 2071-2076, 2015.

(要約): Gastric cancer is one of the most common types of cancer. Cancer stem cells (CSCs) have been reported to play important roles in multiple cancer types. This study investigated the correlation between cluster of differentiation 133 (CD133), histone deacetylase 1 (HDAC1) and thrombospondin-1 (THBS1) expression in advanced gastric cancer. The study included 65 patients with gastric cancer with recurrence after surgery. Expression of CD133, HDAC1 and THBS1 was examined by immunohistochemistry. Prognostic factors were investigated by multivariate analysis using Cox's proportional hazard model. Clinicopathological variables, including survival, of patients positive for CD133 expression (n=6, 23%), were compared with those without CD133 expression (n=20, 77%). Positive HDAC1 expression and THBS1 expression were observed in 34 (52%) and 17 (26%) patients, respectively. Using univariate analysis, positive expression of CD133 and negative expression of THBS1 predicted significantly worse prognosis. Multivariate analysis revealed CD133-positive and THBS1-negative expression were independent prognostic indicators. CD133 expression and THBS1 expression were prognostic factors, and a negative relationship between HDAC and THBS1 was observed in advanced gastric cancer. These biomarkers may help determine postoperative treatment in patients with gastric cancer.
(キーワード): 欧文論文 / Aged / Aged, 80 and over / Antigens, CD / Biomarkers, Tumor / Female / Gene Expression Regulation, Neoplastic / Glycoproteins / Histone Deacetylase 1 / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Neoplasm Recurrence, Local / Neoplastic Stem Cells / Peptides / Prognosis / Stomach Neoplasms / Thrombospondin 1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25862862; ● Search Scopus @ Elsevier (PMID): 25862862

(PubMed: 25862862)

MISC

Chie Takasu, Masaaki Nishi, Kozo Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada :
Preoperative evaluation to determine the difficulty of No. 6 lymphadenectomy in laparoscopic gastrectomy.,
BMC Surgery, Vol.24, No.1, 69, 2024.

(要約): Laparoscopic gastrectomy (LG) requires a long learning curve because of the complicated surgical procedures. Infrapyloric (No. 6) lymph node dissection (LND) is one of the difficult procedures in LG, especially for trainees. This study investigated the impact of the prediction of the difficulty of No. 6 LND. We retrospectively reviewed the preoperative computed tomography (CT) images and individual operative video records of 57 patients who underwent LG with No. 6 LND to define and predict the No. 6 LND difficulty. To evaluate whether prediction of the difficulty of No. 6 LND could improve surgical outcomes, 48 patients who underwent laparoscopic distal gastrectomy were assessed (30 patients without prediction by a qualified surgeon and 18 patients with prediction by a trainee). The anatomical characteristic that LND required > 2 cm of dissection along the right gastroepiploic vein was defined as difficulty of No. 6 LND. Of the 57 LG patients, difficulty was identified intraoperatively in 21 patients (36.8%). Among the several evaluated anatomical parameters, the length between the right gastroepiploic vein and the right gastroepiploic artery in the maximum intensity projection in contrast-enhanced CT images was significantly correlated with the intraoperative difficulty of No. 6 LND (p < 0.0001). Surgical outcomes, namely intraoperative minor bleeding, postoperative pancreatic fistula, and drain amylase concentration were not significantly different between LG performed by a trainee with prediction compared with that by a specialist without prediction. Preoperative evaluation of the difficulty of No. 6 LND is useful for trainees, to improve surgical outcomes.
(キーワード): Humans / Retrospective Studies / Stomach Neoplasms / Lymph Node Excision / Laparoscopy / Gastrectomy / Postoperative Complications
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12893-024-02349-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38389108; ● Search Scopus @ Elsevier (PMID): 38389108; ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-024-02349-8

(DOI: 10.1186/s12893-024-02349-8, PubMed: 38389108) Chie Takasu, Yuji Morine, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada :
Role of stromal PD-L1 expression in colorectal liver metastasis.,
BMC Cancer, Vol.24, No.1, 97, 2024.

(要約): The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM). The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM. Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1- and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008). Stromal PD-L1 expression may be a significant prognostic marker for CRLM.
(キーワード): Humans / B7-H1 Antigen / Colorectal Neoplasms / Immune Checkpoint Inhibitors / Liver Neoplasms / Lymphocytes, Tumor-Infiltrating / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12885-024-11869-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38233811; ● Search Scopus @ Elsevier (PMID): 38233811; ● Search Scopus @ Elsevier (DOI): 10.1186/s12885-024-11869-8

(DOI: 10.1186/s12885-024-11869-8, PubMed: 38233811) Takayuki Noma, Masaaki Nishi, Chie Takasu, Yuuma Wada, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Yuko Miyakami, Kengo Atsumi, Hisanori Uehara and Mitsuo Shimada :
Conversion surgery after successful response to chemotherapy (S-1 + oxaliplatin + nivolumab) in a patient with stage IV gastric cancer with peritoneal metastasis (P1, CY1): a case report.,
International Cancer Conference Journal, Vol.13, No.1, 11-16, 2023.

(要約): We here present a case report of a patient with Stage IV gastric cancer with peritoneal metastasis (P1, CY1) who underwent conversion surgery after a successful response to chemotherapy (S-1 + oxaliplatin + nivolumab). The patient was a woman in her 60 s. Her chief complaint was epigastric pain. Upper gastrointestinal endoscopy showed Type 4 advanced carcinoma on the lesser curvature of the gastric body. Biopsy showed Group 5 (poorly differentiated adenocarcinoma) and HER2 was negative. Staging laparoscopy revealed seeding in the round ligament of the liver (P1) and adenocarcinoma cells in ascites (CY1). Ten courses of chemotherapy (S-1 + oxaliplatin + nivolumab) were administered, after which contrast-enhanced computed tomography showed that the primary tumor had shrunk and seeding was no longer detectable. Upper gastrointestinal endoscopy revealed scar-like changes. A second staging laparoscopy revealed that ascites cytology was negative and a biopsy of the round ligament of the liver showed no malignant cells (P0, CY0). Conversion surgery comprising laparoscopic total gastrectomy with D2 lymph node dissection and resection of the round ligament of the liver was performed. The postoperative course was uneventful. Histopathological examination of the resected specimen revealed no tumor cells in the gastric mesentery or the round ligament of the liver. The pathological diagnosis was gastric cancer [M, U, L, Less, Ant, Post, type4, T3(SS), N0, M0 (H0, P0, CY0), ypStage IIA]. Adjuvant chemotherapy (S-1) was commenced. The patient is still alive 7 months later with no evidence of recurrence.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s13691-023-00628-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38187176; ● Search Scopus @ Elsevier (PMID): 38187176; ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-023-00628-4

(DOI: 10.1007/s13691-023-00628-4, PubMed: 38187176) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
Visualization of the pelvic nerves using magnetic resonance imaging for rectal cancer surgery.,
Surgical Endoscopy, Vol.37, No.6, 4315-4320, 2023.

(要約): This study evaluated the visualization of the pelvic nerves using magnetic resonance imaging (MRI) combined with computed tomography (CT) to synthesize three-dimensional (3D) reconstruction images of the pelvic organs. The CT and MRI scans were performed for patients with rectal cancer who underwent surgery. The out-of-phase image of LAVA-Flex was used to identify the pelvic nerves. The images of the pelvic nerves were extracted from the MRI scans, and those of the arteries and rectum and pelvis were extracted from the CT scans. Each extracted organ image was used to synthesize 3D reconstruction images. The MRI scan allowed adequate visualization of the pelvic splanchnic nerves, inferior hypogastric plexus, and obturator nerves. The comparison of 3D reconstruction images and intraoperative findings showed matched images. We visualized the pelvic nerves using MRI and synthesized 3D reconstruction images of the pelvic organs. Preoperative confirmation of the location of the pelvic organs is important to prevent unanticipated injury during rectal cancer surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00464-022-09771-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36418640; ● Search Scopus @ Elsevier (PMID): 36418640; ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-022-09771-0

(DOI: 10.1007/s00464-022-09771-0, PubMed: 36418640) Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach.,
BMC Surgery, Vol.23, No.1, 128, 2023.

(要約): Robotic surgery (RS) has been rapidly adopted for gastric cancer and adenocarcinoma of the esophagogastric junction (AEG). However, the utility of RS for Siewert type II/III AEG remains unclear. Forty-one patients who underwent either transhiatal RS (n = 15) or laparoscopic surgery (LS) (n = 26) for Siewert type II/III AEG were enrolled in this study. The surgical outcomes of the two groups were compared. In the entire cohort, there were no significant intergroup differences in the operative time, blood loss volume, or number of retrieved lymph nodes. The length of the postoperative hospital stay was shorter in the RS group than in the LS group (14.20 ± 7.10 days vs. 18.73 ± 17.82 days, respectively; p = 0.0388). The morbidity rate (Clavien-Dindo grade ≥ 2) was similar between the groups. In the Siewert II cohort, there were no significant intergroup differences in short-term outcomes. In the entire cohort, there was no significant difference between the RS and LS groups in the 3-year overall survival rate (91.67% vs. 91.48%, N.S.) or 3-year disease-free survival rate (91.67% vs. 91.78%, N.S.), respectively. Likewise, in the Siewert type II cohort, there was no significant difference between the RS and LS groups in the 3-year overall survival rate (80.00% vs. 93.33%, N.S.) or 3-year disease-free survival rate (80.00% vs. 94.12%, N.S.), respectively. Transhiatal RS for Siewert II/III AEG was safe and contributed to similar short-term and long-term outcomes compared with LS.
(キーワード): Humans / Robotic Surgical Procedures / Retrospective Studies / Gastrectomy / Adenocarcinoma / Stomach Neoplasms / Laparoscopy / Esophagogastric Junction / Esophageal Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12893-023-02045-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37194030; ● Search Scopus @ Elsevier (PMID): 37194030; ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-023-02045-z

(DOI: 10.1186/s12893-023-02045-z, PubMed: 37194030) Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada and Toshiaki Yoshimoto :
The application of enhanced recovery after surgery in total gastrectomy: a propensity score-matched analysis.,
World Journal of Surgical Oncology, Vol.21, No.1, 148, 2023.

(要約): This study aimed to investigate the feasibility and safety of our enhanced recovery after surgery protocol including early oral intake and omitting nasogastric tube (NGT) placement after total gastrectomy. We analyzed 182 consecutive patients who underwent total gastrectomy. The clinical pathway was changed in 2015, and patients were divided into 2 groups (conventional group and modified group). Postoperative complications, bowel movement, and postoperative hospital stays were compared in the two groups in all cases and propensity score matching (PSM). Flatus and defecation were significantly earlier in the modified group compared with those in the conventional group (flatus: 2 (1-5) days vs 3 (2-12) days, p = 0.03; defecation: 4 (1-14) days vs 6 (2-12) days p = 0.04). The postoperative hospital stay was 18 (6-90) days in the conventional group and 14 (7-74) days in the modified group (p = 0.009). Days until discharge criteria were met were earlier in the modified group compared with that in the conventional group (10 (7-69) days vs 14 (6-84) days p = 0.01). Overall and severe complications occurred in nine patients (12.6%) and three patients (4.2%) in the conventional group and twelve patients (10.8%) and four patients (3.6%) in the modified group, respectively (p = 0.70 and p = 0.83) in all cases. In PSM, there is no significant difference between the two groups concerning the postoperative complications (overall complication 6 (12.5%) vs 8 (16.7%) p = 0.56, severe complications 1 (2%) vs 2 (4.2%) p = 0.83). Modified ERAS for total gastrectomy may be feasible and safe.
(キーワード): Humans / Enhanced Recovery After Surgery / Propensity Score / Flatulence / Stomach Neoplasms / Retrospective Studies / Gastrectomy / Length of Stay / Postoperative Complications / Treatment Outcome / Laparoscopy
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-023-03034-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37194033; ● Search Scopus @ Elsevier (PMID): 37194033; ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-023-03034-5

(DOI: 10.1186/s12957-023-03034-5, PubMed: 37194033) Toshiaki Yoshimoto, Kouzou Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Takayuki Noma and Mitsuo Shimada :
Surgical Outcomes of Gastrectomy in Hemodialysis Patients with Gastric Cancer.,
The American Surgeon, Vol.89, No.12, 6328-6330, 2023.

(キーワード): Humans / Stomach Neoplasms / Retrospective Studies / Laparoscopy / Gastrectomy / Treatment Outcome / Renal Dialysis
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/00031348231173970
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37132264; ● Search Scopus @ Elsevier (PMID): 37132264; ● Search Scopus @ Elsevier (DOI): 10.1177/00031348231173970

(DOI: 10.1177/00031348231173970, PubMed: 37132264) Takuya Tokunaga, Maki Sugimoto, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Yuhei Waki, Toshiaki Yoshimoto, Takayuki Noma and Mitsuo Shimada :
Transanal lateral lymph node dissection with intraoperative hologram support in low rectal cancer.,
Surgical Endoscopy, Vol.37, No.7, 5414-5420, 2023.

(要約): In Japan, the standard treatment for stage II/III advanced low rectal cancer is total mesorectal excision plus lateral lymph node dissection (LLND). There are also recent reports on the use of transanal LLND. However, the transanal anatomy is difficult to understand, and additional support tools are required to improve the surgical safety. The present study examined the utility of holograms with mixed reality as an intraoperative support tool for assessing the complex pelvic anatomy. Polygon (stereolithography) files of patients' pelvic organs were created and exported from the SYNAPSE VINCENT imaging system and uploaded into the Holoeyes MD virtual reality software. Three-dimensional images were automatically converted into patient-specific holograms. Each hologram was then installed into a head mount display (HoloLens2), and the surgeons and assistants wore the HoloLens2 when they performed transanal LLND. Twelve digestive surgeons with prior practice in hologram manipulation evaluated the utility of the intraoperative hologram support by means of a questionnaire. Intraoperative hologram support improved the surgical understanding of the lateral lymph node region anatomy. In the questionnaire, 75% of the surgeons answered that the hologram accurately reflected the anatomy, and 92% of the surgeons answered that the anatomy was better understood by simulating the hologram intraoperatively than preoperatively. Moreover, 92% of the surgeons agreed that intraoperative holograms were a useful support tool for improving the surgical safety. Intraoperative hologram support improved the surgical understanding of the pelvic anatomy for transanal LLND. Intraoperative holograms may represent a next-generation surgical tool for transanal LLND.
(キーワード): Humans / Treatment Outcome / Lymph Node Excision / Lymph Nodes / Rectal Neoplasms / Dissection
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00464-023-09977-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37017769; ● Search Scopus @ Elsevier (PMID): 37017769; ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-023-09977-w

(DOI: 10.1007/s00464-023-09977-w, PubMed: 37017769) Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Shohei Eto and Toshiaki Yoshimoto :
Usefulness of Diagnostic Staging Laparoscopy for Advanced Gastric Cancer.,
The American Surgeon, Vol.89, No.4, 685-690, 2023.

(要約): For advanced gastric cancer (AGC), peritoneal metastasis is the most common determinant of unresectability, but accurate preoperative diagnosis for peritoneal metastasis is challenging. Staging laparoscopy (SL) can detect unsuspected peritoneal metastasis. This study retrospectively evaluated the utility of SL and its indication in patients with AGC. In this study, we enrolled 114 patients with pathologically diagnosed gastric adenocarcinoma who underwent SL. Of the 114 patients, 43 (37.7%) had peritoneal metastasis (P1 or CY1). Higher age, larger tumor size, type 4 GC, deeper tumor depth, elevated CA125, and ascites findings in preoperative CT were found to be significant predictors of peritoneal metastasis. In multivariate analysis, peritoneal metastasis was associated with type 4 GC (odds ratio [OR]: 6.11; 95% confidence interval [CI]: 1.87-19.8; P < .01) and ascites in CT (OR: 4.25; 95% CI: 1.48-12.1; P < .01). Staging laparoscopy is an effective tool to detect peritoneal metastasis from AGC. It can increase the curative resection rate and decrease unnecessary laparotomies.
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/00031348211038554
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34382447; ● Search Scopus @ Elsevier (PMID): 34382447; ● Search Scopus @ Elsevier (DOI): 10.1177/00031348211038554

(DOI: 10.1177/00031348211038554, PubMed: 34382447) Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Shohei Eto and Toshiaki Yoshimoto :
Transoral Anvil Delivery System With Tension-Free Method for Esophagojejunostomy After Laparoscopic Total Gastrectomy Prevents The Postoperative Stenosis.,
The American Surgeon, Vol.89, No.4, 1066-1068, 2023.

(出版サイトへのリンク): ● Publication site (DOI): 10.1177/0003134820973393
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33307725; ● Search Scopus @ Elsevier (PMID): 33307725; ● Search Scopus @ Elsevier (DOI): 10.1177/0003134820973393

(DOI: 10.1177/0003134820973393, PubMed: 33307725) Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada and Toshiaki Yoshimoto :
Stapler insertion angle toward the esophagus reduces the incidence of early postoperative Roux stasis syndrome after distal gastrectomy in minimally invasive surgery.,
BMC Surgery, Vol.23, No.1, 54, 2023.

(要約): Roux stasis syndrome (RSS) after Roux-en-Y (RY) reconstruction significantly prolongs the hospital stay and decreases the quality of life. The purpose of the present study was to evaluate the incidence of RSS in patients who underwent distal gastrectomy for gastric cancer and to identify the factors related to the development of RSS after mechanical RY reconstruction in minimally invasive surgery (MIS). This study included 134 patients who underwent distal gastrectomy in MIS with mechanical RY anastomosis. RSS was defined as the presence of symptoms such as nausea, vomiting, or abdominal fullness, and the confirmation of delayed gastric emptying on imaging or gastrointestinal fiber testing. Clinical data were checked, including body mass index, operative procedure, age, sex, operative time, blood loss volume, extent of lymph node dissection, final stage, stapler insertion angle, method of entry hole closure. The relationship between the incidence of RSS and these factors was analyzed. RSS occurred in 24 of 134 patients (17.9%). RSS occurred significantly more frequently in patients with D2 lymphadenectomy than in patients with D1 + lymphadenectomy (p = 0.04). All patients underwent side-to-side anastomosis via the antecolic route. The incidence of RSS was significantly greater in patients with a stapler insertion angle toward the greater curvature (n = 20, 22.5%) versus the esophagus (n = 4, 8.9%) (p = 0.04). The multivariate logistic regression model revealed that the stapler insertion angle to the greater curvature is identified as independent risk factor for RSS (OR 3.23, 95%Cl 1.01-10.3, p = 0.04). Stapler insertion angle toward the esophagus may reduce the incidence of early postoperative RSS rather than toward the greater curvature.
(キーワード): Humans / Incidence / Quality of Life / Gastrectomy / Anastomosis, Roux-en-Y / Esophagus / Stomach Neoplasms / Minimally Invasive Surgical Procedures / Postoperative Complications
(徳島大学機関リポジトリ): ● Metadata: 118879
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12893-023-01954-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36906525; ● Search Scopus @ Elsevier (PMID): 36906525; ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-023-01954-3

(徳島大学機関リポジトリ: 118879, DOI: 10.1186/s12893-023-01954-3, PubMed: 36906525) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
The Impact of the Pre-operative Neutrophil-lymphocyte Ratio as the Predictive Marker of Post-operative Weight Loss and Improving Diabetes in Sleeve Gastrectomy.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 140-144, 2023.

(要約): The aim was to investigate the impact of the neutrophil-lymphocyte ratio (NLR) in sleeve gastrectomy (SG). 15 obese patients were enrolled in this study ; mean body weight (BW) 127.5kg ; mean body mass index (BMI) 46.7kg/m. 10 of these were diabetics who underwent a SG. The impact of the pre-operative NLR on the percentage of excess weight loss (%EWL) and remission of diabetes 1 year post-operative were examined. The %EWL at 1 year post-operative were 46.3%. Improvements were also evident in the diabetes at 1 year post-operative : complete remission (CR) 40%, partial remission (PR) 20% and Improve 40%. Comparing pre-operative NLR in %EWL<50% and ≧50% in 1 year post-operative, <50% was 2.64 and ≧50% was 2.03. The NLR in CR and PR was significantly lower than that in Improve. The pre-operative NLR may be a predictive marker of weight loss and improving diabetes after SG. J. Med. Invest. 70 : 140-144, February, 2023.
(キーワード): Humans / Obesity, Morbid / Treatment Outcome / Neutrophils / Retrospective Studies / Laparoscopy / Diabetes Mellitus / Weight Loss / Body Mass Index / Gastrectomy
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.140
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164710; ● Search Scopus @ Elsevier (PMID): 37164710; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.140

(DOI: 10.2152/jmi.70.140, PubMed: 37164710) Kunitsugu Kubota, Toru Kono, Mitsuo Shimada, Atsushi Takata, Jun Higashijima, Kouzou Yoshikawa, Takuya Tokunaga, Naoki Fujitsuka and Alessandro Fichera :
Intestinal hypomotility due to longitudinal enterotomy can be alleviated by transverse closure.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 180-188, 2023.

(要約): Heineke-Mikulicz (HM) strictureplasty is commonly used to treat short stenoses in Crohn's disease. However, the degree to which intestinal motility is maintained remains unclear. We compared the peristalsis and transport capacity of the sutured intestines with HM configuration and transverse (TS) and longitudinal (LS) incisions. The intestinal diameter, intraluminal pressure, and bead transit time of each sutured group were compared with that of the non-treatment (NT) group in the isolated proximal colon of rats. Propulsive contractions were induced using hydroxy-?-sanshool (HAS), a constituent of Japanese pepper. There was no change in the intestinal diameter between HM, TS, and NT groups ; however, it was significantly narrowed at the suture site and its distal side in the LS group. After HAS administration, the intestinal diameter at the suture site in the HM group was higher than that in the LS group. The intraluminal pressure was higher and the transit time was shorter in the HM group compared to those in the LS group. The HM configuration, which widens the incision site and distal diameter and shortens the cut surface of the circular muscle in the longitudinal direction, may help maintain basal and HAS-induced intestinal peristalsis and motility. J. Med. Invest. 70 : 180-188, February, 2023.
(キーワード): Rats / Animals / Intestines / Crohn Disease / Constriction, Pathologic / Colon / Anastomosis, Surgical
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.180
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164718; ● Search Scopus @ Elsevier (PMID): 37164718; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.180

(DOI: 10.2152/jmi.70.180, PubMed: 37164718) Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Shin-ichiro Yamada, Toshiaki Yoshimoto and Mitsuo Shimada :
Prognostic impact of frailty after gastrectomy in elderly gastric cancer patients.,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 423-429, 2023.

(要約): Frailty plays a crucial role in cancer patients who have received surgery in this recent aging society. We aimed to investigate frailty as a prognostic factor in elderly gastric cancer (GC) patients who underwent curative gastrectomy. We analyzed 86 elderly (over 75 years old) GC patients who underwent curative gastrectomy. Patients were assigned to two groups;frailty group (n=29) and no-frailty group (n=57). Clinicopathological values were compared between the two groups. The OS rate of the frailty group was significantly poorer than that of the no-frailty group (5-yr OS rate;frailty group 52.49% vs. no-frailty group 74.87%, p<0.05). Multivariate analysis of the OS showed that frailty tended to be significant prognostic factor (p=0.09). The DFS rate of the frailty group was significantly poorer than that of the no-frailty group (5-yr DFS rate;frailty group 42.30% vs. no-frailty group 71.55%, p<0.05). Multivariate analysis of the DFS showed that frailty tended to be significant prognostic factor (p=0.14). We identified the clinical impact of frailty prognostic factor for elderly GC patients who underwent gastrectomy. J. Med. Invest. 70 : 423-429, August, 2023.
(キーワード): Humans / Aged / Prognosis / Stomach Neoplasms / Frailty / Aging / Gastrectomy / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.423
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940527; ● Search Scopus @ Elsevier (PMID): 37940527; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.423

(DOI: 10.2152/jmi.70.423, PubMed: 37940527) Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto, Shohei Okikawa, Shoko Yamashita and Mitsuo Shimada :
Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy.,
BMC Cancer, Vol.22, No.1, 1263, 2022.

(要約): The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years. This study examined the prognostic significance of indoleamine-pyrrole 2,3-dioxygenase (IDO) expression in patients with LARC who received preoperative CRT. Ninety patients with LARC who underwent preoperative CRT and curative resection were enrolled. IDO and programmed death-ligand 1 (PD-L1) expression was evaluated by immunohistochemistry. Clinicopathological factors did not significantly differ between patients with positive or negative IDO expression, excluding the correlation of positive IDO expression with better tumor differentiation (p = 0.02). IDO expression was not associated with pathological response (p = 0.44), but it was associated with PD-L1 expression. The 5-year overall survival (OS) rate was significantly worse in the IDO-positive group than in the IDO-negative group (64.8% vs. 85.4%, p = 0.02). Univariate analysis identified IDO and PD-L1 expression (p = 0.02), surgical procedure (p = 0.01), final pathological stage (p = 0.003), lymph node metastasis (p < 0.001), and lymphatic invasion (p = 0.002) as significant prognostic factors for OS. Multivariate analysis revealed that IDO expression (HR: 7.10, p = 0.0006), surgical procedure (HR: 5.03, p = 0.01), lymph node metastasis (HR: 2.37, p = 0.04) and lymphatic invasion (HR: 4.97, p = 0.01) were independent prognostic indicators. Disease-free survival was not correlated with IDO or PD-L1 expression. IDO expression in patients with LARC who received preoperative CRT could be a potential prognostic indicator. IDO expression could be a useful marker for specifying individual treatment strategies in LARC.
(キーワード): Humans / B7-H1 Antigen / Chemoradiotherapy / Lymphatic Metastasis / Neoadjuvant Therapy / Prognosis / Rectal Neoplasms / Indoleamine-Pyrrole 2,3,-Dioxygenase
(徳島大学機関リポジトリ): ● Metadata: 118002
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12885-022-10357-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36471264; ● Search Scopus @ Elsevier (PMID): 36471264; ● Search Scopus @ Elsevier (DOI): 10.1186/s12885-022-10357-1

(徳島大学機関リポジトリ: 118002, DOI: 10.1186/s12885-022-10357-1, PubMed: 36471264) 髙須千絵, 調憲, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
オンライン時代は女性医師キャリア形成の追い風となる,
日本消化器外科学会雑誌, Vol.55, No.11, 729-732, 2022年.

(要約): 新型コロナウイルス感染症の拡大が,これまで停滞していた医師の働き方改革の推進へとつながっている.その中でも,学会のオンライン化は医師の働き方に大きな変化をもたらした.学会のリモート参加は,自宅に居ながら参加でき,地方からも参加しやすく,移動時間と費用の大きな削減となる.オンデマンド配信は,時間・場所にかかわらず学ぶ機会を得られる非常に有効なツールとなる.また,学会の委員活動など,習慣的に行われていた対面での会議が,現在はほぼ遠隔で行われている.これまで時間的制約により,積極的に学会活動に手を挙げることができなかった女性医師の同分野での活躍推進が期待される.特に子育て中の女性医師にとって,オンライン化はワーク・ライフ・バランスを維持しながらキャリアを形成していく有効なツールとなりうる.この変化を逃さず女性活躍推進へとつなげるための,オンライン学会(ハイブリット形式)の継続を強く要望したい.(著者抄録)
(キーワード): 育児 *労働衛生 *女性医師抄録作成と索引作成 *職歴の移動テレビ会議 *テレワーキングヒト女
(出版サイトへのリンク): ● Publication site (DOI): 10.5833/jjgs.2022.sr005
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390857226420483072; ● Search Scopus @ Elsevier (DOI): 10.5833/jjgs.2022.sr005

(DOI: 10.5833/jjgs.2022.sr005, CiNii: 1390857226420483072) Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer.,
Oncology Letters, Vol.24, No.5, 415, 2022.

(要約): Previous studies have revealed the usefulness of neoadjuvant chemotherapy (NAC) followed by surgery for clinical stage III gastric cancer (GC). The tumor volume at the primary tumor site (PT) is sometimes difficult to measure because of the luminal structure; therefore, evaluation of the lymph node (LN) response to NAC may help to more accurately predict survival outcomes. The present study therefore evaluated the LN response to NAC for prediction of survival outcomes in patients with GC. The study involved 160 patients with clinical stage III GC who underwent NAC (n=14) and upfront surgery (n=146). PT and LN responses to NAC were evaluated, various clinicopathological factors were evaluated and Cox proportional hazard regression analyses were performed to determine survival outcomes. Overall survival (OS) and disease-free survival (DFS) were not significantly different between patients who underwent NAC and those who underwent upfront surgery (OS, P=0.71; DFS, P=0.50). However, although there were no significant differences in PT responses, patients classified as LN non-responders to NAC had a significantly worse prognosis compared with patients classified as LN responders in terms of DFS (PT, P=0.93; LN, P<0.01) and OS (PT, P=0.84; LN, P<0.01). Moreover, a higher neutrophil-lymphocyte ratio tended to be associated with poor DFS [univariate: hazard ratio (HR)=4.23, P=0.06; multivariate: HR=6.45, P=0.04]. Finally, an LN response to NAC was significantly better for prediction of recurrence (univariate, HR=7.79, 95% confidence interval=1.16-63.51, P=0.02; multivariate, HR=7.44, P=0.01). Overall, the current study revealed the clinical importance of the LN response to NAC for predicting survival outcomes in patients with GC. These findings highlight the potential clinical impact of optimizing treatment strategies to improve the selection and management of patients.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2022.13535
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36245824; ● Search Scopus @ Elsevier (PMID): 36245824; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13535

(DOI: 10.3892/ol.2022.13535, PubMed: 36245824) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
Computed tomography texture analysis for the prediction of lateral pelvic lymph node metastasis of rectal cancer.,
World Journal of Surgical Oncology, Vol.20, No.1, 281, 2022.

(要約): This study aimed to investigate the usefulness of computed tomography (CT) texture analysis in the diagnosis of lateral pelvic lymph node (LPLN) metastasis of rectal cancer. This was a retrospective cohort study of 45 patients with rectal cancer who underwent surgery with LPLN dissection at Tokushima University Hospital from January 2017 to December 2021. The texture analysis of the LPLNs was performed on preoperative CT images, and 18 parameters were calculated. The correlation between each parameter and pathological LPLN metastasis was evaluated. The texture parameters were compared between pathologically metastasis-positive LPLNs and metastasis-negative LPLNs. A total of 40 LPLNs were extracted from 25 patients by preoperative CT scans. No LPLNs could be identified in the remaining 19 patients. Eight of the 25 patients had pathologically positive LPLN metastasis. Extracted LPLNs were analyzed by the texture analysis. Pathologically metastasis-positive LPLNs had significantly lower mean Hounsfield unit, gray-level co-occurrence matrix (GLCM) energy, and GLCM Entropy_log2 values, and a significantly larger volume than pathologically metastasis-negative LPLNs. Multivariate analysis revealed that the independent predictive factors for LPLN metastasis were volume (a conventional parameter) (odds ratio 7.81, 95% confidence interval 1.42-43.1, p value 0.018) and GLCM Entropy_log2 (a texture parameter) (odds ratio 12.7, 95% confidence interval 1.28-126.0, p value 0.030). The combination of both parameters improved the diagnostic specificity while maintaining the sensitivity compared with each parameter alone. Combining the CT texture analysis with conventional diagnostic imaging may increase the accuracy of the diagnosis of LPLN metastasis of rectal cancer.
(キーワード): Humans / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Rectal Neoplasms / Retrospective Studies / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 118078
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-022-02750-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36057660; ● Search Scopus @ Elsevier (PMID): 36057660; ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-022-02750-8

(徳島大学機関リポジトリ: 118078, DOI: 10.1186/s12957-022-02750-8, PubMed: 36057660) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto and Syoko Yamashita :
Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study.,
International Journal of Clinical Oncology, Vol.27, No.9, 1439-1449, 2022.

(要約): This study was performed to assess the impact of osteopenia on chemotherapy-induced neutropenia and the prognosis for patients treated with FOLFOXIRI for colorectal cancer. In total, 77 patients who underwent FOLFOXIRI for un-resectable metastatic and advanced colorectal cancer were retrospectively evaluated. Osteopenia was evaluated by the bone mineral density, which was measured using the average pixel density of the trabecular bone in the 11th thoracic vertebra by computed tomography before the introduction of chemotherapy. The relationship between osteopenia and neutropenia was evaluated. Progression-free survival and overall survival of patients with osteopenia and patients with neutropenia were evaluated. Grade ≥ 3 neutropenia was significantly more common in patients with than without osteopenia (p = 0.002). The multivariate analysis showed that osteopenia was a significant independent predictive factor for grade ≥ 3 neutropenia (p = 0.016). There was no significant difference in progression-free survival or overall survival between patients with and without osteopenia. Patients with grade ≥ 3 neutropenia tended to have a higher progression-free survival rate than others (p = 0.059). The overall survival rate was significantly higher in patients with grade ≥ 3 neutropenia than in others (p = 0.011). Osteopenia might be a predictor of chemotherapy-induced neutropenia, and neutropenia might be a prognostic factor for progression-free survival and overall survival in patients with colorectal cancer treated with FOLFOXIRI.
(キーワード): Antineoplastic Agents / Antineoplastic Combined Chemotherapy Protocols / Bevacizumab / Bone Diseases, Metabolic / Camptothecin / Colorectal Neoplasms / Fluorouracil / Humans / Leucovorin / Neutropenia / Organoplatinum Compounds / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-022-02199-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35908137; ● Search Scopus @ Elsevier (PMID): 35908137; ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-022-02199-5

(DOI: 10.1007/s10147-022-02199-5, PubMed: 35908137) Takuya Tokunaga, Maki Sugimoto, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita, Yosuke Iwakawa, Noriko Yokota and Mitsuo Shimada :
Intraoperative holographic image-guided surgery in a transanal approach for rectal cancer.,
Langenbeck's Archives of Surgery / Deutsche Gesellschaft für Chirurgie, Vol.407, No.6, 2579-2584, 2022.

(要約): Urethral injury is one of the most important complications in transanal total mesorectal excision (TaTME) in male patients with rectal cancer. The purpose of this study was to investigate holographic image-guided surgery in TaTME. Polygon (stereolithography) files were created and exported from SYNAPSE VINCENT, and then uploaded into the Holoeyes MD system (Holoeyes Inc., Tokyo, Japan). After uploading the data, the three-dimensional image was automatically converted into a case-specific hologram. The hologram was then installed into the head mount display, HoloLens (Microsoft Corporation, Redmond, WA). The surgeons and assistants wore the HoloLens when they performed TaTME. In a Wi-Fi-enabled operating room, each surgeon, wearing a HoloLens, shared the same hologram and succeeded in adjusting the hologram by making simple hand gestures from their respective angles. The hologram contributed to better comprehension of the positional relationships between the urethra and the surrounding pelvic organs during surgery. All surgeons were able to properly determine the dissection line. This first experience suggests that intraoperative holograms contributed to reducing the risk of urethral injury and understanding transanal anatomy. Intraoperative holograms have the potential to become a new next-generation surgical support tool for use in spatial awareness and the sharing of information between surgeons.
(キーワード): Dissection / Humans / Laparoscopy / Male / Postoperative Complications / Proctectomy / Rectal Neoplasms / Rectum / Surgery, Computer-Assisted / Transanal Endoscopic Surgery
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00423-022-02607-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35840706; ● Search Scopus @ Elsevier (PMID): 35840706; ● Search Scopus @ Elsevier (DOI): 10.1007/s00423-022-02607-4

(DOI: 10.1007/s00423-022-02607-4, PubMed: 35840706) Yuuma Wada, Masaaki Nishi, Kozo Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Preoperative nutrition and exercise intervention in frailty patients with gastric cancer undergoing gastrectomy.,
International Journal of Clinical Oncology, Vol.27, No.9, 1421-1427, 2022.

(要約): The frailty was associated with the worse surgical outcomes and poor prognosis in several cancers. Therefore, we aimed to identify the usefulness of nutrition and exercise intervention (NEI) in frailty patients with GC. We analyzed 58 frailty patients with GC who underwent radical surgery. Among these, 15 patients were performed NEI by nutritional and rehabilitation support team. We compared the surgical outcomes between NEI and non-NEI groups with frailty patients and evaluated the nutrition and rehabilitation markers in pre- and post-NEI groups. The postoperative complication of NEI groups was 6.7% and less than that of non-NEI groups (p = 0.08). The mean postoperative hospital stay of NEI groups was 13.0 ± 1.0 days for NEI groups and significantly shorter than that of non-NEI groups (p = 0.03). The NLR was 4.3 ± 0.6 for pre-NEI and significantly improved by NEI between pre- and post-NEI (p = 0.03). We identified the clinical importance of NEI for improving the surgical outcomes in frailty patients with GC. Our findings highlight the potential clinical impact of optimizing treatment strategies to select and manage the frailty patients.
(キーワード): Exercise Therapy / Frailty / Gastrectomy / Humans / Postoperative Complications / Preoperative Care / Stomach Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-022-02202-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35771395; ● Search Scopus @ Elsevier (PMID): 35771395; ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-022-02202-z

(DOI: 10.1007/s10147-022-02202-z, PubMed: 35771395) Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada :
Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts.,
Oncology Letters, Vol.24, No.1, 236, 2022.

(要約): Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant.
(徳島大学機関リポジトリ): ● Metadata: 118072
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2022.13356
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469; ● Search Scopus @ Elsevier (PMID): 35720469; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356

(徳島大学機関リポジトリ: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469) Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Chiharu Nakasu and Mitsuo Shimada :
Pincer Approach to Gastrosplenic Ligament in Robotic Total Gastrectomy for Gastric Cancer.,
Journal of Gastrointestinal Surgery, Vol.26, No.7, 1552-1555, 2022.

(キーワード): Gastrectomy / Humans / Laparoscopy / Ligaments / Retrospective Studies / Robotic Surgical Procedures / Robotics / Stomach Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11605-022-05356-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35578006; ● Search Scopus @ Elsevier (PMID): 35578006; ● Search Scopus @ Elsevier (DOI): 10.1007/s11605-022-05356-3

(DOI: 10.1007/s11605-022-05356-3, PubMed: 35578006) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Syoko Yamashita and Yosuke Iwakawa :
Vascular variations encountered during laparoscopic surgery for transverse colon, splenic flexure, and descending colon cancer: a retrospective cohort study.,
BMC Surgery, Vol.22, No.1, 170, 2022.

(要約): Laparoscopic surgery for cancer located in the transverse colon or splenic flexure is difficult because of vascular variability in this region and adjacent vital organs such as the pancreas, spleen, and duodenum. This retrospective cohort study involved 51 patients who underwent laparoscopic surgery for colon cancer at Tokushima University Hospital from July 2015 to December 2020. Variations of the middle colic artery (MCA), left colic artery (LCA), middle colic vein (MCV), and first jejunal vein (FJV) and short-term outcomes of laparoscopic surgery in patients with each vascular variation were evaluated. Variations of the MCA, LCA, MCV, and FJV were classified into four, three, five, and three patterns, respectively. The short-term outcomes of laparoscopic surgery for transverse colon cancer in patients with MCA variations and those with FJV variations were evaluated, and no significant difference was found in the operation time, blood loss, postoperative complication rate, time from surgery to start of dietary intake, or time from surgery to discharge among the different variations. Additionally, no significant differences were found in the short-term outcomes of laparoscopic surgery for descending colon cancer in patients with LCA variations. Preoperative assessment of vascular variations may contribute to the stability of short-term outcomes of laparoscopic surgery for transverse colon, splenic flexure, and descending colon cancer.
(キーワード): Colectomy / Colon, Descending / Colon, Transverse / Colonic Neoplasms / Humans / Laparoscopy / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 118005
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12893-022-01603-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35538458; ● Search Scopus @ Elsevier (PMID): 35538458; ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-022-01603-1

(徳島大学機関リポジトリ: 118005, DOI: 10.1186/s12893-022-01603-1, PubMed: 35538458) Toshiaki Yoshimoto, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Shohei Okikawa and Kouzou Yoshikawa :
Blue light irradiation inhibits the growth of colon cancer and activation of cancer-associated fibroblasts.,
Oncology Reports, Vol.47, No.5, 2022.

(要約): Irradiation with a specific wavelength of light using light-emitting diodes (LEDs) has various effects on cells and organisms. Recently, the antitumor effects of visible blue light on tumor cells were reported; however, the mechanism and effects on the tumor microenvironment remain unclear. Human colon cancer cells (HCT-116) were injected into the rectal wall of nude mice. Tumors were irradiated with a 465-nm LED light at 30 mW/cm for 30 min. Tumor volumes and the expression levels of opsin 3 (Opn3), autophagy-related factors, cancer-associated fibroblast (CAF) markers, and programmed cell death 1-ligand (PD-L1) were measured. Additionally, human intestinal fibroblasts were cultured in HCT116-conditioned medium (CM) to prepare CAFs. CAFs were divided into an LED group and a control group, and the effect of the LED light on CAF activation in colon cancer cells was examined. Irradiation with blue LED light suppressed tumor growth; Opn3 expression was localized to the cell membrane in the LED group. Irradiated tumors exhibited increased autophagy-related gene expression. Furthermore, in the LED group, TGF-β and α-SMA expression levels in the fibroblasts were decreased. Regarding CAFs, α-SMA and IL-6 expression levels were decreased in the LED group. HCT-116 cells cultured in CAF-CM with LED irradiation showed no enhanced migration or invasion. In the HCT-116 cells cultured in CM of CAFs irradiated with LED, the relative increase in PD-L1 expression was lower than that noted in the CAF-CM without LED irradiation. Blue LED light may have a direct antitumor effect on colon cancer and also an inhibitory effect on CAFs.
(キーワード): Animals / B7-H1 Antigen / Cancer-Associated Fibroblasts / Cell Movement / Cell Proliferation / Colonic Neoplasms / HCT116 Cells / Humans / Light / Mice / Mice, Nude / Rod Opsins / Tumor Microenvironment
(徳島大学機関リポジトリ): ● Metadata: 118073
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2022.8315
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35417035; ● Search Scopus @ Elsevier (PMID): 35417035; ● Search Scopus @ Elsevier (DOI): 10.3892/or.2022.8315

(徳島大学機関リポジトリ: 118073, DOI: 10.3892/or.2022.8315, PubMed: 35417035) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Syoko Yamashita and Yosuke Iwakawa :
Risk factors for postoperative ileus after diverting loop ileostomy closure.,
BMC Surgery, Vol.22, No.1, 131, 2022.

(要約): Postoperative ileus is one of the most common complications after diverting loop ileostomy closure. Some reports have investigated the risk factors for postoperative complications or ileus after ileostomy closure; however, these studies did not evaluate the index surgery sufficiently. In this study, we evaluated the risk factors, including the details of the index surgery, for ileus after diverting ileostomy closure. This was a retrospective study of patients who underwent ileostomy closure following index surgery for rectal cancer. Patients who developed postoperative ileus [POI (+)] and patients who did not [POI (-)] after ileostomy closure were compared. Sixty-eight patients were evaluated and were divided into two groups: POI (+) (n = 11) and POI (-) (n = 57), and the groups were compared. There were no significant differences in the details of the index surgery, operative procedure, transanal total mesorectal excision, lateral lymph node dissection, operating time, or blood loss. The incidence of Clavien-Dindo grade ≥ III complications and adjuvant chemotherapy after index surgery were significantly higher in the POI (+) group. The incidence of Clavien-Dindo grade ≥ III complications and adjuvant chemotherapy after index surgery may increase the risk of postoperative ileus after ileostomy closure.
(キーワード): Humans / Ileostomy / Ileus / Postoperative Complications / Rectal Neoplasms / Retrospective Studies / Risk Factors
(徳島大学機関リポジトリ): ● Metadata: 118004
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12893-022-01583-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35392877; ● Search Scopus @ Elsevier (PMID): 35392877; ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-022-01583-2

(徳島大学機関リポジトリ: 118004, DOI: 10.1186/s12893-022-01583-2, PubMed: 35392877) 徳永卓哉, 柏原秀也, 島田光生 :
【大腸外科医のための骨盤解剖学】直腸癌手術に必要な画像シミュレーション,
手術, Vol.76, No.5, 709-714, 2022年.

(キーワード): Fluorouracil(治療的利用) ホログラフィー Leucovorin(治療的利用) 腫瘍多剤併用療法腫瘍侵入性前立腺腫瘍(X線診断,外科的療法,薬物療法) 前立腺切除 X線CT *直腸腫瘍(X線診断,外科的療法,薬物療法) 腹腔鏡法リンパ節切除コンピュータシミュレーション三次元イメージングネオアジュバント療法 Irinotecan(治療的利用) Oxaliplatin(治療的利用) コンピュータ支援手術直腸切断術ロボット手術低位前方切除 FOLFOXIRI Protocol ヒト男
(出版サイトへのリンク): ● Publication site (DOI): 10.18888/op.0000002751
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.18888/op.0000002751

(DOI: 10.18888/op.0000002751) 西正暁, 島田光生, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 和田佑馬 :
【外科代謝栄養と東洋医学:漢方による周術期管理へのサポート】大建中湯による周術期管理のサポート,
外科と代謝·栄養, Vol.56, No.2, 59-61, 2022年.

(要約): 近年では漢方の分子生物学的な作用機序の解明が進み，臨床においても質の高いランダム化比較試験により漢方の有用性が明らかになってきた．現在では大建中湯を含む多くの漢方製剤が広く臨床の現場で用いられている．大建中湯は乾姜，人参，山椒の3つの生薬に膠飴を加えた漢方で，外科領域においては癒着性イレウスや麻痺性イレウス，過敏性腸症候群，クローン病などを適応とし，消化管運動促進作用，腸管血流増加作用，抗炎症作用などが報告されている．近年では，食道・胃・大腸・肝臓・膵臓・肝移植外科それぞれの領域でランダム化試験が実施され，大建中湯の周術期管理における有効性が証明されている．また分子生物学的なメカニズムについても解明がすすみ，現在，大建中湯は消化管外科・肝胆膵外科の分野を問わず消化器外科全般における周術期管理のkey drugとして位置付けられている．本稿では消化器外科領域における大建中湯による周術期管理のサポートについて概説する．(著者抄録)
(キーワード): 消化管運動 *消化器外科バクテリアルトランスロケーション *周術期管理 *大建中湯(薬理学,治療的利用) 伊東細胞腫瘍微小環境ヒト
(出版サイトへのリンク): ● Publication site (DOI): 10.11638/jssmn.56.2_59
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.56.2_59

(DOI: 10.11638/jssmn.56.2_59) Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita and Yosuke Iwakawa :
The correlation of immunoscore and frailty in colorectal cancer.,
International Journal of Clinical Oncology, Vol.27, No.3, 528-537, 2022.

(要約): The Immunoscore is a useful prognostic and predictive factor for colorectal cancer. Frailty predicts overall and recurrence-free survival following resection of colorectal cancer, and the immunosuppressive state of frailty might affect tumor progression. This study investigated the relationship between the Immunoscore and frailty in colorectal cancer. This retrospective study included patients who underwent radical surgery for stage II and III colorectal cancer (n = 108). Patients were divided into frail (n = 11) and non-frail (n = 97) groups, and low (IS0-2) (n = 70) and high (IS3-4) Immunoscore groups (n = 38), for comparison. American Society of Anesthesiologists physical status was higher, tumor diameter was larger, number of well-differentiated tumors was higher, albumin was lower, 5-year overall survival (OS) was lower (frail group: 50.0%, non-frail group: 90.5%, p < 0.001) and 5-year disease-free survival (DFS) was lower (frail group: 36.4%, non-frail group: 75.2%, p = 0.024) in the frail than in the non-frail group. Left colon cancer was more, 5-year OS was lower (IS0-2 group: 82.0%, IS3-4 group: 96.7%, p = 0.040) and 5-year DFS was lower (IS0-2 group: 66.3%, IS3-4 group: 83.3%, p = 0.043) in the IS0-2 than in the IS3-4 group. The Immunoscore was lower in the frail than in the non-frail group. Immunoscore and frailty are prognostic and predictive factors in colorectal cancer, and they are correlated with each other. The immunosuppressive state from frailty might affect this correlation.
(キーワード): Colonic Neoplasms / Colorectal Neoplasms / Disease-Free Survival / Frailty / Humans / Prognosis / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-021-02096-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34846645; ● Search Scopus @ Elsevier (PMID): 34846645; ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-02096-3

(DOI: 10.1007/s10147-021-02096-3, PubMed: 34846645) Shuhai Chen, Masaaki Nishi, Yuji Morine, Mitsuo Shimada, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shinichiro Yamada and Yuma Wada :
Epigallocatechin 3allate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancerssociated fibroblasts.,
International Journal of Oncology, Vol.60, No.2, 2022.

(要約): In recent times, researchers working on tumor metabolism have paid increasing attention to the tumor microenvironment. Emerging evidence has confirmed that epigenetic modifications of cancerssociated fibroblasts (CAFs) alters the characteristics of glucose metabolism to achieve a symbiotic relationship with the cancer cells. Epigallocatechin 3allate (EGCG) exerts antiumor effects via a variety of mechanisms, although the underlying mechanism that accounts for the effects of EGCG on glucose metabolic alterations of CAFs have yet to be elucidated. In the present study, through coulture with colorectal cancer (CRC) cells, human intestinal fibroblasts were transformed into CAFs, and exhibited enhanced aerobic glycolysis. Induced CAFs were able to enhance the proliferation, migration and invasion of CRC cells . EGCG treatment led to direct inhibition of the proliferation and migration of CRC cells; furthermore, EGCG treatment of CAFs suppressed their tumorromoting capabilities by inhibiting their glycolytic activity. Blocking the lactic acid efflux of CAFs with a monocarboxylate transporter 4 (MCT4) inhibitor or through silencing MCT4 could also suppress their tumorromoting capabilities, indicating that lactate fulfills an important role in the metabolic coupling that occurs between CAFs and cancer cells. Taken together, the results of the present study showed that EGCG targeting of the metabolism of tumor stromal cells provided a safe and effective strategy of antiancer therapy.
(キーワード): Cancer-Associated Fibroblasts / Catechin / Colorectal Neoplasms / Humans / Neoplasms / Oxidative Coupling / Warburg Effect, Oncologic
(徳島大学機関リポジトリ): ● Metadata: 117318
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2022.5309
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35029285; ● Search Scopus @ Elsevier (PMID): 35029285; ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2022.5309

(徳島大学機関リポジトリ: 117318, DOI: 10.3892/ijo.2022.5309, PubMed: 35029285) Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Shoko Iwahashi :
Usefulness of a stepwise training program for laparoscopic gastrectomy.,
Asian Journal of Endoscopic Surgery, Vol.15, No.1, 121-127, 2022.

(要約): Laparoscopic gastrectomy (LG) is a complicated procedure with a long learning curve. This study was performed to investigate the usefulness of our stepwise training program for LG for improving the quality of the surgery. The stepwise training method comprised the following four steps: (1) basic training using a dry box and checking by mentors; (2) advanced training, including the use of animals and cadavers; (3) clinical experience, including standardization and preoperative three-dimensional simulation; and (4) self-assessment and feedback. In total, 153 patients who underwent curative gastrectomy for gastric cancer were included in this study. The operative time gradually decreased for both laparoscopic distal gastrectomy (LDG) (2013, 395inutes; 2017, 278inutes; P < .001; = -0.68) and laparoscopic total gastrectomy (LTG) (2013, 476inutes; 2017, 319inutes; P < .001; = -0.56). The blood loss volume gradually decreased for both LDG (2013, 43.0 mL; 2017, 18.6 mL; P < .005; = -0.30) and LTG (2013, 143.8 mL; 2017, 13.5 mL; P < .005; = -0.41). Our stepwise training program contributes to reduce operation time and blood loss in LG.
(キーワード): Gastrectomy / Humans / Laparoscopy / Retrospective Studies / Stomach Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12979
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34514719; ● Search Scopus @ Elsevier (PMID): 34514719; ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12979

(DOI: 10.1111/ases.12979, PubMed: 34514719) Shohei Eto, Kouzou Yoshikawa, Toshiaki Yoshimoto, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Toshihiro Nakao, Jun Higashijima, Takashi Iwata and Mitsuo Shimada :
Strategy for laparoscopic repair of inguinal hernia after robot-assisted radical prostatectomy.,
Asian Journal of Endoscopic Surgery, Vol.15, No.1, 155-161, 2022.

(要約): Robot-assisted radical prostatectomy (RARP) is nowadays being performed worldwide, and inguinal hernia (IH) continues to be a common complication of radical prostatectomy. Laparoscopic repair of IH is often difficult via internal dissection because of adhesion of the preperitoneal cavity. This study aimed to categorize the intraoperative condition of, and devise a strategy for, IH after RARP. Of 577 patients who underwent RARP, 18 developed IH. These 18 patients then underwent laparoscopic IH repair using the transabdominal preperitoneal approach (TAPP) or modified intraperitoneal onlay mesh repair (mIPOM). Internal dissection was categorized into two groups according to the appearance of Cooper's ligament (exposed or not exposed). After RARP, four patients had exposure of Cooper's ligament while 14 patients showed no exposure. Both patients in the exposed group underwent TAPP and all patients in the not-exposed group underwent mIPOM. There was no significant difference between normal TAPP and RARP regarding operative factors, and IH recurrence was not observed. Laparoscopic repair of IH after RARP is rendered safe and efficient by using our categorization based on the exposure of Cooper's ligament and extension of preperitoneal space.
(キーワード): Hernia, Inguinal / Herniorrhaphy / Humans / Laparoscopy / Male / Prostatectomy / Robotics
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12985
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34514724; ● Search Scopus @ Elsevier (PMID): 34514724; ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12985

(DOI: 10.1111/ases.12985, PubMed: 34514724) Chie Takasu, Emiko Kono, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto, Shoko Yamashita and Mitsuo Shimada :
A "diversity and inclusion" lecture for promoting self-awareness among medical students.,
Surgery Today, Vol.52, No.6, 964-970, 2022.

(要約): The concept of 'diversity and inclusion' is being adopted worldwide, but it is not yet understood well in Japan. We conducted this study to evaluate the impact of a lecture aimed at increasing awareness of academic careers and the benefits of having diversity and inclusion. Two female surgeons delivered a 120-min lecture on "diversity and inclusion" to third-year medical students at Tokushima University. To assess the impact of the lecture, a questionnaire was distributed, for participants to complete anonymously before and after the lecture. Eighty-two students participated in the study (39 men, 38 women, and 5 unknown). Based on the questionnaire responses, 57.1% of the students had already perceived inequality in conduct because of gender. A comparison of pre- and post-lecture responses revealed a significant increase in confidence to succeed in their medical career (56.5% vs. 77.5%, p < 0.01). Learners were more likely to believe that gender would not become a barrier to career development (42.4% vs. 66.7%, p < 0.01). Moreover, 90.4% of the students felt positively about a career in surgery following the lecture. The lecture promoted awareness about diversity, self-awareness, and career development and motivated students to consider specializing in surgery later in their career.
(キーワード): Career Choice / Female / Gender Identity / Humans / Japan / Male / Students, Medical / Surveys and Questionnaires
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00595-021-02424-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35001195; ● Search Scopus @ Elsevier (PMID): 35001195; ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02424-0

(DOI: 10.1007/s00595-021-02424-0, PubMed: 35001195) Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Shoko Yamashita :
Propensity Score-Matched Analysis of the Short- and Long-Term Outcomes of Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer.,
Annals of Surgical Oncology, Vol.29, No.6, 3887-3895, 2022.

(要約): Robotic gastrectomy (RG) has been rapidly adopted for gastric cancer (GC) treatment. However, the benefits of RG over laparoscopic gastrectomy (LG) for GC remain unclear. A total of 451 patients who underwent either RG (n = 83) or LG (n = 368) for GC were enrolled in this study. A 1:1 matched, propensity score-matched analysis was performed using the following factors: age, sex, body mass index, pT, pN, pStage, tumor location, vessel invasion, tumor markers, surgical procedure, reconstruction method, extent of lymphadenectomy, and Endoscopic Surgical Skill Qualification System qualified surgeon as an operator. The surgical outcomes of the two groups were compared. A well-balanced cohort of 158 patients was analyzed (n = 79 in the RG group, n = 79 in the LG group). Regarding the short-term outcomes, the respective blood loss volume, drain amylase content, and number of retrieved lymph nodes in the RG and LG groups were 38.62 ± 73.06 ml and 67.53 ± 108.20 ml (p < 0.05), 450 ± 371 IU/l and 1590 ± 6392 IU/l (p < 0.01), and 35.02 ± 15.51 and 25.28 ± 11.70 (p < 0.01). The morbidity rate was similar between the RG and LG groups (not significant [NS]). Regarding the long-term survival outcomes, there were no intergroup differences in 3-year overall survival (91.72% in the RG group vs. 83.39% in the LG group: NS) and 3-year, disease-free survival (93.31% in the vs. 90.44%: NS). RG was safe and contributed to better short-term outcomes and similar long-term survival outcomes compared with LG.
(キーワード): Gastrectomy / Humans / Laparoscopy / Postoperative Complications / Propensity Score / Retrospective Studies / Robotic Surgical Procedures / Stomach Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-021-11203-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35006502; ● Search Scopus @ Elsevier (PMID): 35006502; ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-021-11203-7

(DOI: 10.1245/s10434-021-11203-7, PubMed: 35006502) Shuhai Chen, Tetsuya Ikemoto, Takuya Tokunaga, Shohei Okikawa, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Yuji Morine and Mitsuo Shimada :
Newly Generated 3D Schwann-Like Cell Spheroids From Human Adipose-Derived Stem Cells Using a Modified Protocol.,
Cell Transplantation, Vol.31, 9636897221093312, 2022.

(要約): Peripheral nerve injury (PNI) is a relatively frequent type of trauma that results in the suffering of many patients worldwide every year. Schwann cells (SCs) are expected to be applied in cell therapy because of their ability to promote peripheral nerve regeneration. However, the lack of clinically renewable sources of SCs hinders the application of SC-based therapies. Adipose-derived stem cells (ADSCs) have generated great interest in recent years because of their multipotency and ease of harvest, and they have already been verified to differentiate into Schwann-like cells (SLCs) in vitro. However, the efficiency of differentiation and the functions of SLCs remain unsatisfactory. We newly generated three-dimensional (3D) SLC spheroids from ADSCs using a modified protocol with human recombinant peptide (RCP) petaloid -piece. Morphological analysis, gene expression analysis by qRT-PCR, ELISA measurement of the secretion capabilities of neurotrophic factors, and neurite formation assay were performed to evaluate the functions of these 3D SLCs in vitro. Motor function recovery was measured in a sciatic nerve injury mouse model to analyze the nerve regeneration-promoting effect of 3D SLCs in vivo. The differentiation efficiency and the secretion of neurotrophic factors were enhanced in 3D SLCs compared with conventional SLCs. 3D SLCs could more effectively promote neurite growth and longer neurite extension in a neuron-like SH-SY5Y model. Additionally, 3D SLCs had a better therapeutic effect on nerve regeneration after transplantation into the sciatic nerve injury mouse model. These findings demonstrated that the potential of ADSC-derived SLCs to promote nerve regeneration could be significantly increased using our modified differentiation protocol and by assembling cells into a 3D sphere conformation. Therefore, these cells have great potential and can be used in the clinical treatment of PNI.
(キーワード): Adipocytes / Adipose Tissue / Animals / Humans / Mice / Nerve Growth Factors / Peripheral Nerve Injuries / Schwann Cells / Stem Cells
(徳島大学機関リポジトリ): ● Metadata: 117435
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/09636897221093312
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35469470; ● Search Scopus @ Elsevier (PMID): 35469470; ● Search Scopus @ Elsevier (DOI): 10.1177/09636897221093312

(徳島大学機関リポジトリ: 117435, DOI: 10.1177/09636897221093312, PubMed: 35469470) Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Shoko Yamashita :
Short-term outcomes of laparoscopic / robotic gastrectomy compared with open gastrectomy for advanced gastric cancer following chemotherapy.,
The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 261-265, 2022.

(要約): Purpose : This study aimed to investigate the short-term outcomes of laparoscopic gastrectomy / robotic gastrectomy after chemotherapy in patients with advanced gastric cancer and compare these outcomes with those of open gastrectomy. Methods : Fifty patients who underwent radical gastrectomy for advanced gastric cancer after chemotherapy between 2007 and 2021 were retrospectively analyzed. The patients were divided into two groups : the laparoscopic gastrectomy / robotic gastrectomy (n = 11) and open gastrectomy (n = 39) groups. The short-term outcomes of these procedures were subsequently examined. Results : The laparoscopic gastrectomy / robotic gastrectomy group had significantly shorter hospital stays and lower intraoperative blood loss than the open gastrectomy group. The overall complication rates were 12.8% (5 of 39 patients) and 0% (0 of 11 patients) in the open gastrectomy and laparoscopic gastrectomy / robotic gastrectomy groups, respectively (P = 0.1). Conclusions : Laparoscopic gastrectomy / robotic gastrectomy may be a surgical option after chemotherapy for patients with advanced gastric cancer. J. Med. Invest. 69 : 261-265, August, 2022.
(キーワード): Gastrectomy / Humans / Laparoscopy / Retrospective Studies / Robotic Surgical Procedures / Stomach Neoplasms / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 117728
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.261
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244778; ● Search Scopus @ Elsevier (PMID): 36244778; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.261

(徳島大学機関リポジトリ: 117728, DOI: 10.2152/jmi.69.261, PubMed: 36244778) Jun Higashijima, Toru Kono, Mitsuo Shimada, Ayumu Sugitani, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga and Kouzou Yoshikawa :
High Ligation of the Inferior Mesenteric Artery Induces Hypoperfusion of the Sigmoid Colon Stump During Anterior Resection.,
Frontiers in Surgery, Vol.8, 756873, 2021.

(要約): Anastomotic leakage (AL) after colorectal surgery is associated with insufficient vascular perfusion of the anastomotic ends. This study aimed to evaluate the effect of high vs. low ligation of the ileocolic artery and inferior mesenteric artery, respectively, on the vascular perfusion of the bowel stumps during ileocecal resection (ICR) and anterior rectal resection (AR). We retrospectively evaluated patients who underwent ICR or AR between 2016 and 2020. Real-time indocyanine green fluorescence angiography was performed to measure the fluorescence time (FT) as a marker of the blood flow in the proximal and distal stumps before anastomosis. Thirty-four patients with lower right-sided colon cancer underwent laparoscopic ICR. Forty-one patients with rectosigmoid colon or rectal cancer underwent robotic high AR (HAR) ( = 8), robotic low AR (LAR) ( = 6), laparoscopic HAR ( = 8), or laparoscopic LAR ( = 19). The FT was similar in the ileal and ascending colon stumps ( = 1.000) and did not differ significantly between high vs. low ligation of the ileocolic artery ( = 0.934). The FT was similar in the sigmoid colon and rectal stumps ( = 0.642), but high inferior mesenteric artery ligation significantly prolonged FT in the sigmoid colon during AR compared with low ligation ( = 0.004), indicating that the high ligation approach caused significant hypoperfusion compared with low ligation. The AL rate was similar after low vs. high ligation. Low vascular perfusion of the bowel stumps may not be an absolute risk factor for AL. High inferior mesenteric artery ligation could induce sigmoid colon stump hypoperfusion during anterior rectal resection.
(徳島大学機関リポジトリ): ● Metadata: 117310
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fsurg.2021.756873
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34966775; ● Search Scopus @ Elsevier (PMID): 34966775; ● Search Scopus @ Elsevier (DOI): 10.3389/fsurg.2021.756873

(徳島大学機関リポジトリ: 117310, DOI: 10.3389/fsurg.2021.756873, PubMed: 34966775) Chie Takasu, Shoko Yamashita, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
The role of the immunoescape in colorectal cancer liver metastasis.,
PLoS ONE, Vol.16, No.11, e0259940, 2021.

(要約): The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study investigated the effects of immune molecules on the prognosis of CRLM. We enrolled 71 patients with CRLM who underwent curative resection for CRC. We used immunohistochemistry to analyze the expression of PD-1, PD-L1, indoleamine-pyrrole 2,3-dioxygenase (IDO), and CD163 (a marker of tumor-associated macrophages [TAMs]) in metastatic tumors. The immune molecules PD-1, PD-L1, IDO, and TAMs were expressed in 32.3%, 47.8%, 45.0%, and 47.9% of metastatic CRC samples, respectively. The 5-year overall survival rates associated with immune molecule-positive groups were significantly better than in the negative groups (PD-1: 87.7% vs 53.2%, p = 0.023; PD-L1: 82.4% vs 42.3%, p = 0.007; IDO: 80.7% vs 43.5%, p = 0.007; TAMs: 82.6% vs 48.0%, p = 0.005). Multivariate analysis revealed PD-1 expression (p = 0.032, hazard ratio: 0.19), IDO expression (p = 0.049, hazard ratio: 0.37), and tumor differentiation (p<0.001, hazard ratio: 0.02) as independent prognostic indicators. PD-1 and TAMs in metastases were associated with less aggressive features such as smaller tumors. Furthermore, TAMs positively and significantly correlated with PD-1 expression (p = 0.011), PD-L1 expression (p = 0.024), and tended to correlate with IDO expression (p = 0.078). PD-1, PD-L1, IDO, and TAMs in CRLM were associated with less aggressive features and better prognosis of patients with CRC, indicating adaptive antitumor immunity vs immune tolerance. These molecules may therefore serve as prognostic markers for CRLM.
(キーワード): Adaptive Immunity / Adult / Aged / Aged, 80 and over / Antigens, CD / Antigens, Differentiation, Myelomonocytic / B7-H1 Antigen / Biomarkers, Tumor / Colonic Neoplasms / Colorectal Neoplasms / Diagnostic Tests, Routine / Female / Gene Expression / Humans / Immune Tolerance / Indoleamine-Pyrrole 2,3,-Dioxygenase / Japan / Liver / Liver Neoplasms / Male / Middle Aged / Neoplasm Metastasis / Prognosis / Programmed Cell Death 1 Receptor / Receptors, Cell Surface / Rectal Neoplasms / Transcriptome / Tumor-Associated Macrophages
(徳島大学機関リポジトリ): ● Metadata: 117381
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0259940
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34797860; ● Search Scopus @ Elsevier (PMID): 34797860; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0259940

(徳島大学機関リポジトリ: 117381, DOI: 10.1371/journal.pone.0259940, PubMed: 34797860) Takuya Tokunaga, Hideya Kashihara, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Chie Takasu, Shohei Eto, Toshiaki Yoshimoto and Mitsuo Shimada :
A Transabdominal Robotic Purse-String Suture Technique for Transanal Total Mesorectal Excision.,
Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A, Vol.31, No.8, 937-941, 2021.

(要約): Transanal total mesorectal excision (TaTME) is a novel technique that overcomes the problem of access to the deep pelvis during radical surgery for mid-rectal and lower rectal cancer. Although TaTME has several important steps, the creation of the distal purse-string suture following TaTME plays an important role in ensuring the integrity of the colorectal anastomosis. However, this procedure represents a major technical challenge for the surgeon. Robot-assisted surgery may make this suturing procedure easier than laparoscopic surgery because it permits intuitive wrist movements and a three-dimensional view. The aim of the present study was to investigate the usefulness of transabdominal robotic purse-string suture during anastomosis in TaTME. Twenty-seven patients, who underwent anastomosis using a single stapling technique (SST) during the TaTME of mid-rectal or lower rectal cancer, were enrolled in the study. The patients were allocated to two groups: 11 patients underwent transabdominal robotic purse-string suturing (the Robot group) and 16 patients underwent transanal purse-string suturing (the Transanal group). The characteristics and short-term surgical outcomes of the participants were compared between the two groups. The Robot group tended to have a shorter purse-string suturing time (541 206 seconds versus 729 310 seconds; = .07). Regarding the shape of the "donut" after SST anastomosis, in the Transanal group, 5 of the 16 participants had incomplete donuts with muscular defects and required additional suturing, whereas in the Robot group, all the participants had complete donuts ( = .04). Transabdominal robotic purse-string suturing may facilitate the suturing procedure and contribute to reliable anastomosis.
(キーワード): Humans / Laparoscopy / Rectal Neoplasms / Rectum / Robotic Surgical Procedures / Robotics / Suture Techniques / Transanal Endoscopic Surgery
(出版サイトへのリンク): ● Publication site (DOI): 10.1089/lap.2021.0286
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34242512; ● Search Scopus @ Elsevier (PMID): 34242512; ● Search Scopus @ Elsevier (DOI): 10.1089/lap.2021.0286

(DOI: 10.1089/lap.2021.0286, PubMed: 34242512) Masaaki Nishi, Mitsuo Shimada, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuuma Wada, Shohei Eto and Toshiaki Yoshimoto :
Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer.,
World Journal of Surgical Oncology, Vol.19, No.1, 201, 2021.

(要約): The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host-tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer.
(キーワード): C-Reactive Protein / Chemoradiotherapy / Humans / Lymphocytes / Neoplasm Staging / Prognosis / Rectal Neoplasms / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 117394
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-021-02319-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34229704; ● Search Scopus @ Elsevier (PMID): 34229704; ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02319-x

(徳島大学機関リポジトリ: 117394, DOI: 10.1186/s12957-021-02319-x, PubMed: 34229704) Jun Higashijima, Toru Kono, Mitsuo Shimada, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Ayumu Sugitani and Kouzou Yoshikawa :
Intestinal hypoperfusion in patients with Crohn's disease revealed by intraoperative indocyanine green fluorescence imaging.,
Annals of Medicine and Surgery, Vol.66, 102402, 2021.

(要約): Anastomotic leakage has been reported as an independent risk factor for surgical recurrence at the anastomotic site in patients with Crohn's disease. An inadequate blood supply may contribute to this leakage. Real-time indocyanine green angiography has been useful for confirming vascular perfusion of the intestines. The aim of this study was to evaluate the use of intraoperative indocyanine green angiography to detect vascular perfusion of the intestines during ileocaecal resection in patients with Crohn's disease and colon cancer. We retrospectively evaluated the medical records of 26 consecutive patients with colon cancer arising in the caecum or ascending colon and 3 consecutive patients with Crohn's disease without a history of disease-related surgery. The patients in the 2 cohorts had undergone ileocaecal resection at Tokushima University Hospital between January 2018 and January 2021. After ileocaecal resection, blood flow was evaluated in ileal (oral) and colon (anal) stapled stumps by indocyanine green fluorescence angiography. The fluorescence time was defined as the time from indocyanine green injection and flush of the injection route to the point when the stump showed the strongest fluorescent signal in the monitor. The fluorescence time for the ileal and colon stumps in patients with Crohn's disease was 43.3 8.8 s each and was significantly longer than the fluorescence time in the patients with colon cancer (29.4 6.5 s and 29.6 6.8 s, respectively) (P < 0.05). Intraoperative indocyanine green fluorescence imaging is safe and reproducible for assessing intestinal perfusion prior to anastomosis in patients with colon cancer and Crohn's disease.
(徳島大学機関リポジトリ): ● Metadata: 117278
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amsu.2021.102402
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34136203; ● Search Scopus @ Elsevier (PMID): 34136203; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amsu.2021.102402

(徳島大学機関リポジトリ: 117278, DOI: 10.1016/j.amsu.2021.102402, PubMed: 34136203) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto :
The influence and countermeasure of obesity in laparoscopic colorectal resection.,
Annals of Gastroenterological Surgery, Vol.5, No.5, 677-682, 2021.

(要約): The aim of this study was to investigate the influence of obesity and the usefulness of a preoperative weight loss program (PWLP) for obese patients undergoing laparoscopic colorectal resection (LCR). Study 1: 392 patients who underwent LCR for colorectal cancer were divided into two groups: those with a body mass index (BMI) ·25 kg/m (n = 113) and those with a BMI <25 kg/m (n = 279). The influence of BMI on LCR was investigated. Study 2: Patients with a BMI ·28 kg/m who were scheduled to undergo LCR (n = 7, mean body weight 87.0 kg, mean BMI 33.9 kg/m) undertook a PWLP including caloric restriction and exercise for 29.6 (15-70) days. The effects of this program were evaluated. Study 1: The BMI ·25 kg/m group had a prolongation of operation time and hospital stay than the BMI <25 kg/m group. Study 2: The patients achieved a mean weight loss of 6.9% (-6.0 kg). The mean visceral fat area was significantly decreased by 18.0%, whereas the skeletal muscle mass was unaffected. The PWLP group had a significantly lower prevalence of postoperative complications compared with the BMI ·25 kg/m group. Obesity affected the surgical outcomes in LCR. A PWLP may be useful for obese patients undergoing LCR.
(徳島大学機関リポジトリ): ● Metadata: 117274
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ags3.12455
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34585052; ● Search Scopus @ Elsevier (PMID): 34585052; ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12455

(徳島大学機関リポジトリ: 117274, DOI: 10.1002/ags3.12455, PubMed: 34585052) Chie Takasu, Katsuki Miyazaki, Kouzou Yoshikawa, Masaaki Nishi, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto, Hirohisa Ogawa, Yuji Morine and Mitsuo Shimada :
Effect of TU-100 on Peyer's patches in a bacterial translocation rat model.,
Annals of Gastroenterological Surgery, Vol.5, No.5, 683-691, 2021.

(要約): Daikenchuto (TU-100), a Japanese herbal medicine, is widely used for various gastrointestinal diseases. We have previously reported that TU-100 suppresses CPT-11-induced bacterial translocation (BT) by maintaining the diversity of the microbiome. In this study we show that TU-100 modulates the immune response during BT by inducing PD-1 expression in Peyer's patches. Eighteen male Wistar rats were divided into four groups: a control group; a control + TU-100 group, given TU-100 1000 mg/kg orally for 5 d; a BT group, given CPT-11 250 mg/kg intra-peritoneal for 2 d; and a TU-100 group, given TU-100 1000 mg/kg orally for 5 d with CPT-11 250 mg/kg intra-peritoneal on days 4 and 5. The size of Peyer's patch was significantly bigger in the BT group compared to the control group (9.0 104 m vs 29.4 104 m, < .05), but improved in the TU-100 group (15.4 104 m, < .005). TU-100 significantly induced PD-1 expression in Peyer's patch compared to the control group and the BT group (control vs BT vs TU-100 = 4.3 4.9 vs 5.1 10.3 vs 17.9 17.8). The CD4 cells were increased in the BT group ( < .05) compared to the control group but decreased in the TU-100 group. The Foxp3 cells were increased in the BT group compared to the control group ( < .05), and further increased in the TU-100 group compared to the BT group. CPT-11 significantly increased TLR4, NF- , TNF- mRNA expressions in the BT group. TU-100 cotreatment significantly reversed these mRNA expressions. TU-100 may have a protective effect against BT through PD-1 expression in Peyer's patch.
(徳島大学機関リポジトリ): ● Metadata: 117275
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ags3.12460
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34585053; ● Search Scopus @ Elsevier (PMID): 34585053; ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12460

(徳島大学機関リポジトリ: 117275, DOI: 10.1002/ags3.12460, PubMed: 34585053) Toshiaki Yoshimoto, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Chiharu Nakasu and Mitsuo Shimada :
Robotic-assisted total gastrectomy in a patient with gastric cancer associated with situs inversus totalis: With video.,
Asian Journal of Endoscopic Surgery, Vol.14, No.2, 297-300, 2021.

(要約): Situs inversus totalis (SIT) refers to an inverted position of the major visceral organ as a "mirror image" of the regular location. We present a video of a robotic-assisted total gastrectomy in a 84-year-old man with SIT. The patient was diagnosed with advanced gastric cancer in the U region. The port placement was done as mirror images of our usual settings. Lymph node dissection was performed with a completely reverse approach to the usual procedure. After total gastrectomy, an intracorporal esophagojejunostomy was performed by circular method. All procedures were performed safely with no intraoperative complications and the patient was discharged uneventfully. Pathological diagnosis confirmed moderately differentiated adenocarcinoma and the depth of invasion was to the subserosa; there were five metastatic lymph nodes. In patients who have gastric cancer with SIT, a robotic-assisted total gastrectomy can be performed safely without surgical complication. Robots are useful for performing a total gastrectomy in SIT.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12860
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32875706; ● Search Scopus @ Elsevier (PMID): 32875706; ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12860

(DOI: 10.1111/ases.12860, PubMed: 32875706) Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Takuya Tokunaga and Masaaki Nishi :
Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma.,
World Journal of Surgical Oncology, Vol.19, No.1, 94, 2021.

(要約): Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. One hundred and twenty patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled. Frailty was defined as a clinical frailty scale score ·4. Patients were divided into frailty (n = 29) and non-frailty (n=91) groups, and clinicopathological factors were compared between the two groups. The frailty group showed an older age, lower serum albumin concentration, lower prognostic nutritional index, larger tumor diameter, and higher rate of lymph node metastasis than the non-frailty group (p < 0.05). Neutrophil-lymphocyte ratio and modified Glasgow prognostic score tended to be higher in the frailty group. Cancer-specific and disease-free survival rates were significantly poor in the frailty group (p < 0.05). With a multivariate analysis, frailty was an independent prognostic factor of cancer-specific survival. Frailty can predict the prognosis of patients with pancreatic ductal adenocarcinoma who undergo pancreatic resection.
(キーワード): Aged / Carcinoma, Pancreatic Ductal / Frailty / Humans / Pancreatectomy / Pancreatic Neoplasms / Prognosis
(徳島大学機関リポジトリ): ● Metadata: 116675
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-021-02205-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33781262; ● Search Scopus @ Elsevier (PMID): 33781262; ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02205-6

(徳島大学機関リポジトリ: 116675, DOI: 10.1186/s12957-021-02205-6, PubMed: 33781262) Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Masaaki Nishi, Takuya Tokunaga, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada :
The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.,
Oncotarget, Vol.12, No.4, 333-343, 2021.

(要約): Cancer-tumor associated macrophage (TAM)-cancer associated fibroblast (CAF) interactions are an important factor in the tumor microenvironment of hepatocellular carcinoma. Hepatic stellate cells (HSCs) were cultured with cancer cell-conditioned medium (Ca.-CM), TAM-CM and CAF-CM, and the expression of CAF markers were evaluated by RT-PCR. Whether HSCs cultured with Ca.-CM, TAM-CM and CAF-CM contributed to the enhanced malignancy of cancer cells was examined using proliferation, invasion and migration assays. Furthermore, the differences between these three types of CM were evaluated using cytokine arrays. HSCs cultured with Ca.-CM, TAM-CM and CAF-CM showed significantly increased mRNA expression of SMA, FAP and IL-6. All HSCs cultured with each CM exhibited significantly increased proliferation, invasion and migration of cancer cells. The osteopontin concentration was significantly higher in HSCs cultured with TAM-CM than the other CAF-CMs. Osteopontin inhibition significantly reduced osteopontin secretion from HSCs cultured with TAM-CM and suppressed the proliferation and invasion of cancer cells enhanced by HSCs cultured with TAM-CM. We observed enhanced osteopontin secretion from TAMs, and this increased osteopontin further promoted osteopontin secretion from HSCs cultured with TAM-CM, leading to increased malignancy. For the first time, we demonstrated the importance of cancer-TAM-CAF interactions via osteopontin in hepatocellular carcinoma.
(徳島大学機関リポジトリ): ● Metadata: 116612
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.27881
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33659044; ● Search Scopus @ Elsevier (PMID): 33659044; ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.27881

(徳島大学機関リポジトリ: 116612, DOI: 10.18632/oncotarget.27881, PubMed: 33659044) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto :
Pre-operative Weight Loss Program for Obese Patients Undergoing Laparoscopic Gastrectomy.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 165-169, 2021.

(要約): Background : The aim of this study was to investigate the influence of obesity and the usefulness of a pre-operative weight loss program (PWLP) for obese patients undergoing laparoscopic gastrectomy (LG) for gastric cancer (GC). Materials and Methods : Study1 : 219 patients who underwent laparoscopic distal gastrectomy (LDG) for GC were divided into 2 groups : body mass index (BMI) 28 and BMI < 28kg /2. The influence of BMI in LG surgery was investigated. Study2 : The BMI 28 kg /2 patients with a planned LG (n = 8) undertook a PWLP including calorie restriction and exercise. The effects of this program were evaluated. Results : Study1 : The BMI 28kg /2 group showed significantly longer operation times, more blood loss and a higher frequency of post-operative complications than that of the BMI < 28kg /2 group. Study 2 : The patients achieved a weight loss of 4.2%. The visceral fat area (VFA) was significantly decreased by 10.6%, whereas skeletal muscle mass was unaffected. The PWLP group showed shorter operation times, less blood loss and a lower frequency of post-operative complications compared with that of the BMI 28kg /2 group. Conclusion : Obesity is an important risk factor and a pre-operative weight loss program is useful for obese patients undergoing a LG. J. Med. Invest. 68 : 165-169, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116007
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.165
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994464; ● Search Scopus @ Elsevier (PMID): 33994464; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.165

(徳島大学機関リポジトリ: 116007, DOI: 10.2152/jmi.68.165, PubMed: 33994464) Jun Higashijima, Takuya Tokunaga, Toshiaki Yoshimoto, Shohei Eto, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Hiroshi Okitsu, Masashi Ishikawa, Hidenori Miyake, Toshiyuki Yagi, Toru Kono and Mitsuo Shimada :
A multicenter phase II trial of preoperative chemoradiotherapy with S-1 plus oxaliplatin and bevacizumab for locally advanced rectal cancer.,
International Journal of Clinical Oncology, Vol.26, No.5, 875-882, 2021.

(要約): We clarified the safety and efficacy of preoperative chemoradiotherapy for locally advanced rectal cancer using a multidrug regimen (S-1 +xaliplatin +evacizumab). This multicenter phase II trial involved 47 patients with locally advanced rectal cancer. All patients received S-1 orally (80 mg/m/day on days 1-5, 8-12, 15-19, and 22-26) and infusions of oxaliplatin (50 mg/m on days 1, 8, 15, and 22) and bevacizumab (5 mg/kg on days 1 and 15). The total radiation dose was 40 Gy delivered in daily fractions of 2 Gy via the four-field technique. The primary endpoint was the pathological complete response rate. The secondary endpoints were safety (incidence of adverse events) and clinical response, relapse-free survival, overall survival, local recurrence, R0 resection, downstaging, and treatment completion rates. All 47 patients received chemoradiotherapy, and 44 patients underwent curative resection. Two patients refused surgery and selected a watch-and-wait strategy. The pathological complete response rate was 18.2% in patients who underwent curative resection. The clinical response rate was 91.3% in 46 patients. Concerning hematotoxicity, there was one grade 4 adverse event (2.1%) and seven grade 3 events (14.9%). Diarrhea was the most frequent non-hematotoxic event, and the grade 3 event rate was 25.5%. Although preoperative chemoradiotherapy for patients with locally advanced rectal cancer using the S-1 +xaliplatin +evacizumab regimen did not achieve the expected pathological complete response rate, this regimen led to an improved clinical response rate.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-021-01868-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33486623; ● Search Scopus @ Elsevier (PMID): 33486623; ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-01868-1

(DOI: 10.1007/s10147-021-01868-1, PubMed: 33486623) Shoko Yamashita, Masaaki Nishi, Tetsuya Ikemoto, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Shohei Eto, Toshiaki Yoshimoto and Mitsuo Shimada :
Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery.,
Surgery Today, Vol.51, No.6, 1022-1027, 2021.

(要約): Venous thromboembolism (VTE) is a major complication after abdominal surgery; however, the best strategy for preventing VTE after surgery is not yet established. We performed this study to investigate the incidence of perioperative VTE and evaluate the efficacy of a VTE preventive strategy for patients undergoing surgery for colorectal cancer (CRC). The subjects of this retrospective analysis were 228 patients who underwent curative surgical resection for CRC between 2012 and 2016. The patients were treated with thromboprophylaxis including enoxaparin. We assessed the perioperative VTE occurrence rate and investigated the risk factors for postoperative VTE. Among the 228 patients, 77 had a preoperative D-dimer level of > 1.0 g/mL and 12 had deep vein thrombosis (DVT) diagnosed by ultrasonography preoperatively. Of the remaining 216 patients, short-term VTE (< 30 days) developed in two patients (0.9%) and long-term VTE (30 days-3 years) developed in seven (3.2%). The mortality rate of patients with VTE was 0%. The univariate analysis indicated that pulmonary disease was the risk factor for short-term VTE, whereas obesity, hyperlipidemia, and a preoperative history of pulmonary embolism were the risk factors for long-term VTE (p < 0.05). The findings of this analysis show that our preventive protocol including enoxaparin is an effective strategy for preventing postoperative VTE.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00595-020-02201-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33387025; ● Search Scopus @ Elsevier (PMID): 33387025; ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-020-02201-5

(DOI: 10.1007/s00595-020-02201-5, PubMed: 33387025) Shohei Okikawa, Jun Higashijima, Masaaki Nishi, Toshiaki Yoshimoto, Shohei Eto, Chie Takasu, Hideya Kashihara, Takuya Tokunaga, Kouzou Yoshikawa and Mitsuo Shimada :
SDF-1 expression after preoperative chemoradiotherapy is associated with prognosis in patients with advanced lower rectal cancer.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 309-314, 2021.

(要約): Stromal cell-derived factor-1 (SDF-1) expression is associated with cancer progression, as a biomarker of prognosis. We clarified the significance of SDF-1 expression on chemoradiotherapy (CRT) resistance and prognosis in advanced lower rectal cancer patients. We evaluated 98 patients with advanced lower rectal cancer who underwent preoperative CRT. All patients received 40 Gy of radiation therapy, with concurrent chemotherapy containing fluorinated pyrimidines, followed by surgical resection. SDF-1 expression in surgical specimens was examined by immunohistochemistry. We divided the patients into SDF-1-positive- (n = 52) and SDF-1-negative groups (n = 46) and compared the clinicopathological factors and survival rates. The SDF-1-positive group was more resistant to CRT than the SDF-1-negative group (non-responder rate, 63.5% vs. 47.8%, respectively ; p = 0.12). Overall survival (OS) in the SDF-1 positive group was significantly poorer vs. the SDF-1-negative group (5-year OS, 73.4% vs. 88.0%, respectively ; p = 0.02), and disease-free survival (DFS) was worse (5-year DFS, 61.0% vs. 74.1%, respectively ; p = 0.07). Multivariate analysis confirmed that SDF-1 expression was a significant independent prognostic predictor of OS (p = 0.04). SDF-1 expression after preoperative CRT is significantly associated with a poor prognosis in advanced lower rectal cancer patients and is a promising biomarker. J. Med. Invest. 68 : 309-314, August, 2021.
(キーワード): Chemoradiotherapy / Disease-Free Survival / Humans / Neoplasm Staging / Prognosis / Rectal Neoplasms / Rectum
(徳島大学機関リポジトリ): ● Metadata: 116500
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.309
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759150; ● Search Scopus @ Elsevier (PMID): 34759150; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.309

(徳島大学機関リポジトリ: 116500, DOI: 10.2152/jmi.68.309, PubMed: 34759150) Shohei Eto, Kouzou Yoshikawa, Yukako Takehara, Toshiaki Yoshimoto, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Toshihiro Nakao, Jun Higashijima, Takashi Iwata and Mitsuo Shimada :
Usefulness of a multidisciplinary surgical site infection team in colorectal surgery.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 256-259, 2021.

(要約): Background : Surgical site infection (SSI) is an adverse event that places a major burden on patients and staff. In this study, we examined the occurrence of SSI and the characteristics of patients referred to the SSI team after colorectal surgery. Methods : In total, 955 patients underwent colorectal surgery at our hospital from 2014 to 2019. Of these 955 patients, 516 received therapeutic support by the SSI team from 2017 to 2019. All patients were evaluated using an SSI surveillance sheet, and we checked for reports of SSI once a month. Each attending physician performed SSI prophylaxis (use of new instruments before wound irrigation and closure). Results : SSI occurred in 80 (8.4%) patients. The incidence of SSI and the incidence of surface SSI were higher in the patients who did not receive intervention by the SSI team than in the patients who did. Organ /pace SSI occurred in 18 patients. Among patients with surface SSI, Enterococcus was the most commonly detected bacteria. Among the 18 patients with organ /pace SSI, 5 developed anastomotic leakage and 4 developed intra-abdominal abscesses. Conclusions : An SSI team for prevention and treatment of infection may contribute to reduction of SSI. J. Med. Invest. 68 : 256-259, August, 2021.
(キーワード): Colorectal Surgery / Humans / Incidence / Risk Factors / Surgical Wound Infection / Therapeutic Irrigation
(徳島大学機関リポジトリ): ● Metadata: 116491
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.256
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759140; ● Search Scopus @ Elsevier (PMID): 34759140; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.256

(徳島大学機関リポジトリ: 116491, DOI: 10.2152/jmi.68.256, PubMed: 34759140) Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto :
Impact of CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) expression in gastric cancer.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 362-367, 2021.

(要約): Background : CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1 (PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods : A total of 105 patients who had undergone curative surgical resection for stage II /II GC at Tokushima University Hospital were included in this study. The expression of CMTM6 was examined by immunohistochemistry. Additionally, the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results : CMTM6 was not positively correlated with any of the factors examined. The overall survival (OS) rates were significantly poorer in the CMTM6 high-expression group than in the CMTM low-expression group (5-year OS : 57.2% vs. 79.2%, respectively ; p < 0.05). Disease-free survival (DFS) was significantly poorer in the CMTM high-expression group than in the CMTM6 low-expression group (5-year DFS : 52.8% vs. 72.4%, respectively ; p < 0.05). Multivariate analysis confirmed CMTM6 expression as an independent prognostic factor in DFS (p < 0.05). CMTM6 expression tended to be correlated with PD-L1 expression (p = 0.07). Conclusions : CMTM6 is associated with a poor prognosis and immunotolerance through PD-L1 in GC. J. Med. Invest. 68 : 362-367, August, 2021.
(キーワード): B7-H1 Antigen / Chemokines / Humans / MARVEL Domain-Containing Proteins / Myelin Proteins / Prognosis / Stomach Neoplasms / Survival Rate
(徳島大学機関リポジトリ): ● Metadata: 116552
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.362
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759159; ● Search Scopus @ Elsevier (PMID): 34759159; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.362

(徳島大学機関リポジトリ: 116552, DOI: 10.2152/jmi.68.362, PubMed: 34759159) Shuhai Chen, Tetsuya Ikemoto, Takuya Tokunaga, Shohei Okikawa, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada :
Effective in vitro differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 347-353, 2021.

(要約): Peripheral nerve injury (PNI) after pelvic surgery is a common issue with a significant impact on patients. Autologous nerve grafting is the gold standard treatment for PNI, but this technique cannot be applied to fine nerve fibers in the pelvis. Schwann-like cell (SLC) differentiation is a novel therapeutic strategy for this clinical condition. However, the efficiency of SLC differentiation remains unsatisfactory. We modified an SLC differentiation protocol using adipose-derived stem cells (ADSCs) and folic acid. Morphology, gene expression and secretion of neurotrophic factors were examined to assess the differentiation quality and phenotypic characteristics. Our new modified protocol effectively induced a Schwann cell (SC) phenotype in ADSCs as assessed by morphology and expression of SC markers [S100 calcium-binding protein B (S100B), P < 0.01 ; p75 neurotrophic receptor (p75NTR), P < 0.05]. SLCs produced by the new protocol displayed a repair phenotype with decreased expression of ERBB2 and early growth response protein 2 (EGR2) /ROX20 (P < 0.01). Furthermore, our new protocol enhanced both mRNA expression and secretion of nerve growth factors by SLCs (P < 0.01). This protocol enhanced the SC characteristics and functions of ADSC-derived SLCs. This promising protocol requires further research and may contribute to SC-based nerve regeneration. J. Med. Invest. 68 : 347-353, August, 2021.
(キーワード): Adipose Tissue / Cell Differentiation / Cells, Cultured / Dietary Supplements / Folic Acid / Humans / Stem Cells
(徳島大学機関リポジトリ): ● Metadata: 116542
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.347
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759157; ● Search Scopus @ Elsevier (PMID): 34759157; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.347

(徳島大学機関リポジトリ: 116542, DOI: 10.2152/jmi.68.347, PubMed: 34759157) 髙須千絵, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 徳永卓哉, 柏原秀也, 武原悠花子 :
夢を実現し，輝く女性外科医たち-求められるサポート体制と働き方改革- 地方外科から発信するダイバーシティ・インクルージョンを目指した取り組み,
日本外科学会雑誌, Vol.121, No.6, 692-693, 2020年.

(キーワード): *労働衛生 *女性医師 *病院人事管理文化の多様性ワークライフバランス *外科医ヒト女

Chie Takasu, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Impact of sidedness of colorectal cancer on tumor immunity.,
PLoS ONE, Vol.15, No.10, e0240408, 2020.

(要約): Clinical and molecular characteristics differ between right-sided and left-sided colorectal cancer (CRC). This study aimed to clarify the correlation between CRC sidedness and tumor immunity. A total of 102 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of programmed cell death (PD)-1, PD1-ligand 1 (PD-L1), forkhead box P3 (Foxp3), transforming growth factor (TGF)-β, and indoleamine-pyrrole 2,3-dioxygenase (IDO) were examined using immunohistochemistry and the relationships between sidedness and several prognostic factors were examined. Clinicopathological factors were not significantly different between right- and left-sided CRC. The tumor immunity-related molecule PD-L1 was more highly expressed in right-sided than in left-sided CRC (62.9% vs. 30.6%, p<0.01). No significant difference was found in overall survival (OS) and disease-free survival (DFS) by sidedness. PD-1 and Foxp3 expression were significant prognostic factors for OS. Lymph node metastasis (N), lymphatic invasion (ly), and PD-L1 expression were significant prognostic factors for DFS. In right-sided CRC, IDO-positive patients had a poor OS (p<0.05), and IDO was the only independent prognostic indicator for OS. N and venous invasion were identified as independent prognostic indicators for DFS. In left-sided CRC, univariate analysis identified PD-1, PD-L1, and Foxp3 expression as significant predictors of poor OS. Multivariate analysis confirmed PD-L1 expression as an independent prognostic indicator. N, ly, and PD-L1 expression levels were identified as significant predictors of poor DFS. The prognostic factors were IDO in right-sided CRC and PD-L1 and Foxp3 in left-sided CRC. These findings indicated that tumor immunity might play different roles depending upon sidedness. Tumor location may be an important factor to consider when assessing immune response and therapeutic decisions in CRC patients.
(キーワード): Adult / Aged / Aged, 80 and over / B7-H1 Antigen / Biomarkers, Tumor / Colorectal Neoplasms / Disease-Free Survival / Female / Forkhead Transcription Factors / Gene Expression Regulation, Neoplastic / Humans / Indoleamine-Pyrrole 2,3,-Dioxygenase / Male / Middle Aged / Neoplasm Staging / Prognosis / Programmed Cell Death 1 Receptor / Transforming Growth Factor beta / Up-Regulation
(徳島大学機関リポジトリ): ● Metadata: 115400
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0240408
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33045001; ● Search Scopus @ Elsevier (PMID): 33045001; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0240408

(徳島大学機関リポジトリ: 115400, DOI: 10.1371/journal.pone.0240408, PubMed: 33045001) Shogo Oota, Masaaki Nishi, Takuya Tokunaga, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Hideya Kashihara, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada :
Usefulness of an ICG fluorescence catheter system in TaTME for avoiding intraoperative urethral injury.,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 285-288, 2020.

(要約): Sometimes intraoperative urethral injury occurs in Transanal total mesorectal excision (TaTME). The aim of this study is to investigate the usefulness of indocyanine green (ICG) fluorescent catheter system for avoiding intraoperative urethral injury in TaTME in experimental model. A urethral catheter was filled with the mixture of albumin and ICG and raw hams were applied in layers as the surrogate model of rectourethral muscle. The detectability of ICG fluorescence in this catheter was investigated by using laparoscope-type fluorescence camera system. Fluorescence was detected when ICG was mixed with albumin or peripheral blood. ICG fluorescence could be detected within 4 mm depth of layered raw hams as the surrogate model. Quantitative analysis of the picture detected that ICG fluorescence plateaued in lower concentration than that of serum. ICG fluorescent catheter system may be useful for avoiding intraoperative urethral injury in TaTME. J. Med. Invest. 67 : 285-288, August, 2020.
(徳島大学機関リポジトリ): ● Metadata: 115426
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.285
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148903; ● Search Scopus @ Elsevier (PMID): 33148903; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.285

(徳島大学機関リポジトリ: 115426, DOI: 10.2152/jmi.67.285, PubMed: 33148903) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto :
Trans-abdominal Pre-peritoneal (TAPP) Inguinal Hernia Repair with Liquid-injection and Gauze Dissection.,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 271-273, 2020.

(要約): Purpose : This report describes a novel technique for trans-abdominal pre-peritoneal (TAPP) inguinal hernia repair using liquid injection and gauze dissection. Methods : Twenty-five cases underwent TAPP inguinal hernia repair with liquid-injection and gauze dissection. Before the initial peritoneal incision, liquid injection was performed percutaneously into the pre-peritoneal space at the outside of the internal inguinal ring and the inside of the seminal duct. Especially, at the inside of the seminal duct, the liquid was injected into the space between the superficial and deep lobe of pre-peritoneal fascia. Gauze was effectively used to dissect this liquid-injected space. Results : In comparison with the cases of inguinal hernia repair without liquid-injection and gauze dissection, the cases who underwent TAPP inguinal hernia repair with liquid-injection and gauze dissection experienced shorter operation times and no complications or recurrence. Conclusions : TAPP inguinal hernia repair with liquid-injection and gauze dissection appears to be a safe and feasible procedure. J. Med. Invest. 67 : 271-273, August, 2020.
(徳島大学機関リポジトリ): ● Metadata: 115423
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.271
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148900; ● Search Scopus @ Elsevier (PMID): 33148900; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.271

(徳島大学機関リポジトリ: 115423, DOI: 10.2152/jmi.67.271, PubMed: 33148900) Yukako Takehara, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Desmoid-type fibromatosis difficult to distinguish from GIST : A case report.,
The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 375-377, 2020.

(要約): Background : Desmoid-type fibromatosis is a very rare disease that has no characteristic image findings, so it is often difficult to differentiate from gastrointestinal stromal tumor (GIST). A case of desmoid-type fibromatosis that was difficult to differentiate from GIST is reported. The decisive factor in the diagnosis was positive nuclear immunostaining for β-catenin nucleus. Case presentation : A man is his 30s had no significant past medical history, including no abdominal surgery. A medical check-up found a large tumor in the right lateral abdomen. After some examinations, a preoperative diagnosis of GIST was made, and open ileocecal resection was performed. However, the final diagnosis based on the pathological findings was desmoid-type fibromatosis. Conclusions : We should consider desmoid-type fibromatosis when we find a large abdominal mass, but it may be difficult to diagnose based only on imaging findings. Immunohistochemical examination of the specimen may make the diagnosis. J. Med. Invest. 67 : 375-377, August, 2020.
(徳島大学機関リポジトリ): ● Metadata: 115460
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.375
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148921; ● Search Scopus @ Elsevier (PMID): 33148921; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.375

(徳島大学機関リポジトリ: 115460, DOI: 10.2152/jmi.67.375, PubMed: 33148921) Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Toshiaki Yoshimoto and Mitsuo Shimada :
Usefulness of virtual three-dimensional image analysis in inguinal hernia as an educational tool.,
Surgical Endoscopy, Vol.34, No.2, 1923-1928, 2020.

(要約): The pre-operative three-dimensional (3D) imaging technique has resulted in a better surgical outcome for patients and has been used as an education and diagnostic tool. However, there are no reports concerning the usefulness of the 3D imaging technique in laparoscopic transabdominal pre-peritoneal repair (TAPP) so the aim of this study was to investigate the usefulness of the 3D imaging technique in laparoscopic TAPP as an educational tool for medical students. Six (6) patients who underwent laparoscopic TAPP for inguinal hernia were enrolled in this study. 3D reconstruction was performed from pre-operative computed tomography (CT) and the usefulness of pre-operative 3D simulation compared with intra-operative laparoscopic imaging was validated. Moreover, thirty (30) medical students at the university completed a multiple-choice questionnaire (MCQ) to determine the level of their satisfaction and understanding of anatomy resulting from the study. The local anatomy of the patients was identified as the same during the operation as the pre-operative 3D simulation. The results of the MCQ showed that most of the medical students were extremely (23%) or very (67%) satisfied with the effect of pre-operative 3D simulation on the quality of the surgery. Moreover, most students could understand the surgery anatomy by the 3D simulation extremely well (40%) or very well (47%) and agreed on the usefulness of this procedure for learning anatomy. Pre-operative 3D simulation increases the understanding of detailed anatomy and virtual three-dimensional image analysis in laparoscopic TAPP is useful as an educational tool for medical students.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00464-019-06964-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31312962; ● Search Scopus @ Elsevier (PMID): 31312962; ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-019-06964-y

(DOI: 10.1007/s00464-019-06964-y, PubMed: 31312962) 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 :
【最先端医療を支える病理学】消化管最新外科手術における病理の役割,
四国医学雑誌, Vol.76, No.1-2, 3-8, 2020年.

(キーワード): *胃腫瘍(外科的療法,病理学) 細胞診術中期生活の質 *直腸腫瘍(外科的療法) 保険適用範囲 *ロボット手術ヒト
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050566774761702016

(CiNii: 1050566774761702016) Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Mitsuo Shimada :
The usefulness of intraoperative X-ray fluoroscopy in avoiding urethral injury during transanal total mesorectal excision.,
Asian Journal of Endoscopic Surgery, Vol.13, No.2, 242-245, 2020.

(要約): Urethral injury is one of the most important complications that can occur during transanal total mesorectal excision in male patients with rectal cancer. This report shows the usefulness of intraoperative X-ray fluoroscopy to avoid urethral injury associated with transanal total mesorectal excision. Real-time navigation using fluoroscopy was performed to check the distance between the urethra and the dissection line at the level of the exposed rectourethral muscle, the middle level of the divided rectourethral muscle, and the level at which the prostate was identified. The dissection was completed transanally up to the level of peritoneal reflection on the anterior side without urethral injury. Pathological examination confirmed that the circumferential resection margin was tumor free. This novel technique using intraoperative X-ray fluoroscopy is an easy-to-use approach that helps prevent urethral injury in male patient who undergo transanal total mesorectal excision for rectal cancer.
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12717
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31215751; ● Summary page in Scopus @ Elsevier: 2-s2.0-85083042497

(DOI: 10.1111/ases.12717, PubMed: 31215751, Elsevier: Scopus) Daichi Ishikawa, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa and Mitsuo Shimada :
The Role of Neutrophil-to-lymphocyte Ratio on the Effect of CRT for Patients With Rectal Cancer.,
In Vivo, Vol.34, No.2, 863-868, 2020.

(要約): Neutrophil-to-lymphocyte ratio (NLR) is an indicator of systemic inflammation and could be a predictive factor in malignant tumors. The aim of this study was to investigate the impact of NLR in patients with lower rectal cancer who received preoperative chemo-radiotherapy (CRT). Forty-eight patients with lower rectal cancer who underwent preoperative CRT and curative resection were enrolled. Blood samples were obtained before and after CRT. The relationship of NLR with clinical outcome was investigated. Post-CRT NLR was higher compared to pre-CRT NLR. The patients with higher post-CRT NLR tended to have worse pathological response to CRT compared to those with low post-CRT NLR. The patients with high post-CRT NLR showed poorer 5-year overall survival and 3-year disease free survival while there was no correlation according to pre-CRT NLR. The univariate analysis showed that post-CRT stage and post-CRT NLR were associated with a poorer 5-year overall survival. NLR after preoperative CRT could be a potential prognostic indicator for patients with lower rectal cancer.
(キーワード): Aged / Aged, 80 and over / Biomarkers, Tumor / Chemoradiotherapy / Combined Modality Therapy / Female / Humans / Leukocyte Count / Lymphocytes / Male / Middle Aged / Neoplasm Staging / Neutrophils / Preoperative Care / Prognosis / Rectal Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/invivo.11850
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32111796; ● Search Scopus @ Elsevier (PMID): 32111796; ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.11850

(DOI: 10.21873/invivo.11850, PubMed: 32111796) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi and Chie Takasu :
Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation.,
Obesity Surgery, Vol.29, No.9, 2745-2749, 2019.

(要約): The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery. The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group. In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11695-019-03922-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31209833; ● Search Scopus @ Elsevier (PMID): 31209833; ● Search Scopus @ Elsevier (DOI): 10.1007/s11695-019-03922-4

(DOI: 10.1007/s11695-019-03922-4, PubMed: 31209833) 岩橋祥子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 島田光生 :
骨髄異形成症候群・発作性夜間血色素尿症合併胃癌に対する腹腔鏡手術の1例,
日本外科系連合学会誌, Vol.44, No.4, 706-712, 2019年.

(キーワード): Haptoglobins(治療的利用)
(出版サイトへのリンク): ● Publication site (DOI): 10.4030/jjcs.44.706
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390848250139518080; ● Search Scopus @ Elsevier (DOI): 10.4030/jjcs.44.706

(DOI: 10.4030/jjcs.44.706, CiNii: 1390848250139518080) Shoko Iwahashi, Masaaki Nishi, Toshiaki Yoshimoto, Hideya Kashihara, Chie Takasu, Takuya Tokunaga, Tomohiko Miyatani, Jun Higashijima, Kouzou Yoshikawa, Yuuma Wada, Yoshimi Bando and Mitsuo Shimada :
A case of gastric heterotopic pancreas with gastroduodenal invagination.,
Surgical Case Reports, Vol.5, No.1, 110, 2019.

(要約): Heterotopic pancreas (HP) is a rare disease commonly found incidentally on imaging studies, at endoscopy or at autopsy and can be associated with abdominal pain, vomiting, heart burn, gastric outlet obstruction, and even dysphagia in very rare cases. Heinrich's classified HP into three groups, types1-3, with Heinrich's type 3 HP the rarest and difficult to diagnose properly because it has only pancreatic ducts but has no islet and acini. The aim of this study is to report a case of gastric outlet obstruction caused by type 3 HP with gastroduodenal invagination with reference to the literature and diagnosed finally by immuno-histochemical analysis. The case presented is a 40-year-old male presenting with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and he was referred to the Tokushima University. Gastric fiber showed that the pedunculated mass originated from the stomach. An open distal gastrectomy was performed. Pathologically, there was small glands proliferation in the sub-mucosal (SM) layer which was membrane and cytoplasm (MUC)1 positive and muscle proliferation. This finding revealed the tumor as HP. Postoperative course was uneventful and the patient was discharged 12 days after surgery. The patient has remained well 12 months after surgery. HP should be considered in the differential diagnosis of SM tumors with gastroduodenal invagination even if this is a rare symptom.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s40792-019-0669-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31292813; ● Search Scopus @ Elsevier (PMID): 31292813; ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-019-0669-7

(DOI: 10.1186/s40792-019-0669-7, PubMed: 31292813) Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara and Chie Takasu :
Usefulness of blood flow evaluation by indocyanine green fluorescence system in laparoscopic anterior resection.,
The Journal of Medical Investigation : JMI, Vol.66, No.1.2, 65-69, 2019.

(要約): One of the major cause of anastomotic leakage (AL) in anterior resection of the rectum is insufficient blood flow of the remnant colon. The indocyanine green fluorescence system (ICG-FS) can visualize the blood flow of organs intra-operatively. The aim of this study is to investigate the usefulness of ICG-FS for evaluating the blood flow of the remnant colon in laparoscopic anterior resection. Rectal cancer patients (n=24) who underwent laparoscopic anterior resection were included in this study. After resection of the rectum, 7.5mg of ICG was administered intravenously, and the blood flow of the oral stump was evaluated by the ICG-FS. The relationship between the fluorescence time (FT) of the oral stump and AL was investigated retrospectively. Two of twenty-four patients (8.3%) suffered AL. The FT of these two cases were over 60 seconds. In the case with the FT was over 80 seconds, we performed additional resection of the late fluorescence portion of the remnant colon and could avoid AL. In patients whose FT was under 60 seconds, no patients suffered AL. ICG-FS may be useful for evaluating the blood flow of the remnant colon to avoid AL in laparoscopic anterior resection. J. Med. Invest. 66 : 65-69, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113323
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.65
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064957; ● Search Scopus @ Elsevier (PMID): 31064957; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.65

(徳島大学機関リポジトリ: 113323, DOI: 10.2152/jmi.66.65, PubMed: 31064957) Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada :
Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons.,
The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 280-284, 2019.

(要約): Purpose The aim of this study was to investigate the utility the three-dimensional (3D) imaging for laparoscopic gastrectomy performed by trainee surgeons. Methods 3D-reconstruction was performed using multi-detector computed tomography (MDCT) and SYNAPSE VINCENT software. Trainee surgeons made 3D-imaging and checked the anatomical structure. Thirty-three patients who underwent laparoscopic gastrectomy (LG) for gastric cancer were examined. Trainees performed 19 LG, while specialists performed 14 LG. The vascular pattern and the surgical outcomes were evaluated. Result 3D imaging depicted the correct positional relationship between the gastric vasculatures and the organs. Regarding vascular pattern detected by 3D imaging, the origins of the infrapyloric artery were the right gastroepiploic artery in 12 cases (36%), the gastroduodenal artery in eight cases (24%), the bifurcation of the right gastroepiploic artery and gastroduodenal artery in seven cases (21%), and not detected in one case (3%). The types of confluence of the infrapyloric vein were the right gastroepiploic vein in 16 cases (48%), the anterior superior pancreatoduodenal vein in 10 cases (30%), and not detected in seven cases (21%). Surgical outcomes were not different between trainee group using intraoperative 3D image with the specialist in instruction group without the intraoperative 3D image. Conclusions Preoperative 3D imaging might contribute to successful and safe LG by trainee surgeons. J. Med. Invest. 66 : 280-284, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114074
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.280
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656289; ● Search Scopus @ Elsevier (PMID): 31656289; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.280

(徳島大学機関リポジトリ: 114074, DOI: 10.2152/jmi.66.280, PubMed: 31656289) Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Yasuhiro Hamada :
The Effect of Laparoscopic Sleeve Gastrectomy on Obesity and Obesity-related Disease : the Results of 10 Initial Cases.,
The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 289-292, 2019.

(要約): Introduction : The number of patients who undergo laparoscopic sleeve gastrectomy (LSG) has been increasing. Department of Surgery, Tokushima University performed the first LSG in 2013. The aim of this study was to report the results of the initial ten cases who underwent a LSG. Patients and methods : Ten obese patients : five males and five females ; age range from thirty-three years to fifty-six years (mean age 42.2 years) ; mean body mass index (BMI) 50.3 ; five with diabetes ; nine with hypertension (HT) ; four with hyperlipidemia (HL) ; eight with sleep apnea syndrome (SAS) who underwent LSG were enrolled in this study. The data was analyzed retrospectively and included short- and long-term outcomes. Results : There were no post-operative complications in this study. The %EWL at three and six months and one year post-operative were 44.2%, 50.2% and 48.6% respectively. In three months post-operative the non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) had improved transaminase (AST/ALT), liver to spleen ratio in plain CT value. Improvements were also evident in the obesity-related diseases : diabetes 80% (4/5) ; HT 67% (6/9) ; HL 75% (3/4) ; and SAS 88% (7/8). Conclusion : LSG is a promising option for the treatment of morbid obesity and obesity-related diseases. J. Med. Invest. 66 : 289-292, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114081
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.289
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656291; ● Search Scopus @ Elsevier (PMID): 31656291; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.289

(徳島大学機関リポジトリ: 114081, DOI: 10.2152/jmi.66.289, PubMed: 31656291) Masaaki Nishi, Bat-Erdene Batsaikhan, Kozo Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada :
High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer.,
Anticancer Research, Vol.37, No.12, 6723-6729, 2017.

(要約): The aim of this study was to investigate the significance of signal transducer and activator of transcription 4 (STAT4) expression and the correlation between STAT4 and interferon gamma (IFN- ) in patients with gastric cancer. Sixty-two patients who underwent gastrectomy for gastric cancer were enrolled in the study. STAT4 and IFNG mRNA expression was evaluated by quantitative real-time polymerase chain reaction (PCR). Immunohistochemistry was performed to examine CD8 T-cells, and STAT4 and IFN- expression. STAT4 mRNA expression was significantly correlated with IFNG mRNA expression (p<0.05). Regarding disease-free survival, there was a significant difference between the groups with high and low STAT4 expression (5-year disease-free survival: 77.8% and 56.4%, p<0.05). Univariate analysis revealed that tumor differentiation and STAT4 expression were significant factors for tumor recurrence. High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy.
(キーワード): Aged / Disease-Free Survival / Female / Gastrectomy / Gene Expression Regulation, Neoplastic / Humans / Interferon-gamma / Kaplan-Meier Estimate / Male / Neoplasm Recurrence, Local / Outcome Assessment (Health Care) / Prognosis / STAT4 Transcription Factor / Stomach Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.12131
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29187449; ● Search Scopus @ Elsevier (PMID): 29187449; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.12131

(DOI: 10.21873/anticanres.12131, PubMed: 29187449) Shohei Eto, Kouzou Yoshikawa, Masaaki Nishi, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Takashi Iwata and Mitsuo Shimada :
Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection.,
Gastric Cancer, Vol.19, No.2, 466-471, 2016.

(要約): Programmed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1 and PD-L1 expression and to analyze the relationships among PD-1, PD-L1, and Foxp3 expression in gastric cancer. A total of 105 patients who underwent curative gastrectomy for stage II/III gastric cancer were included in this study. PD-1, PD-L1, and Foxp3 expression were examined by immunohistochemistry and related to prognostic factors by univariate and multivariate analyses. PD-1 expression was correlated with both PD-L1 and Foxp3 expression. Disease-free survival (DFS) was significantly poorer in PD-1-positive patients than in PD-1-negative patients (3-year DFS, 36.1 % vs. 64.7 %, respectively; p < 0.05). Overall survival also tended to be poorer in PD-L1-positive patients than in PD-L1-negative patients. Univariate analysis identified sex, T factor, lymphatic invasion, and PD-1 positivity as significant predictors of poor DFS. Multivariate analysis confirmed male sex, lymphatic invasion, and positive PD-1 expression as independent prognostic indicators. PD-1 expression is associated with a poor prognosis and is correlated with PD-L1 and Foxp3 expression in patients with gastric cancer.
(キーワード): Adult / Aged / Aged, 80 and over / Antigens, CD274 / Biomarkers, Tumor / Female / Forkhead Transcription Factors / Gastrectomy / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Prognosis / Programmed Cell Death 1 Receptor / Stomach Neoplasms
(徳島大学機関リポジトリ): ● Metadata: 109661
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10120-015-0519-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26210691; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937959229

(徳島大学機関リポジトリ: 109661, DOI: 10.1007/s10120-015-0519-7, PubMed: 26210691, Elsevier: Scopus)

総説・解説

研究者総覧に該当データはありませんでした。

講演・発表

Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada :
Circulating exosomal microRNA signature to predict peritoneal metastasis in patients with advanced gastric cancer.,
ASCO-GI, San Francisco, Jan. 2024. Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
Immunoscore and Frailty in Colorectal Cancer,
IASGO-CME Advanced Post-Graduate Course in Kobe 2023, Kobe, Nov. 2023. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Toshiaki Yoshimoto and Yukako Takehara :
The impact of preoperative neutrophil-lymphocyte ratio as the predictive marker of postoperative weight loss and improving diabetes in sleeve gastrectomy.,
SAGES 2020, クリーブランド, Aug. 2020. Kouzou Yoshikawa, Mitsuo Shimada, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
The usefuluness of the OrVil method in LATG,
SAGES 2020, クリーブランド, Aug. 2020. Takuya Tokunaga, Kouzou Yoshikawa, Tomohiko Miyatani, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto, Yukako Takehara and Mitsuo Shimada :
The Usefulness of Intraoperative X-ray Fluoroscopy for Avoiding Urethral Injury in Transperineal total Mesorectal Excision,
IASGO2019, Bangkok, Oct. 2019. Toshiaki Yoshimoto, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada :
The tumor suppressive effects of blue LED via Opn3 in colon cancer,
第10回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2019. Kouzou Yoshikawa, Mitsuo Shimada, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
The usefulness of the orVil method in LATG,
第10回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2019. Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
The usefulness of our step-wise training system for robotic assisted gastrectomy,
SAGES 2019, Baltimore, Apr. 2019. Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Mitsuo Shimada :
Examination of the VR+AR training for understanding of regional anatomy in the laparoscopic training of the students.,
SAGES 2019, Baltimore, Apr. 2019. Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara and Chie Takasu :
Preoperative Chemoradiotherapy for Lower-Advanced Rectal Cancer Patients Using SOX+Bev Regimen,
SSO's 72nd Annual Cancer Symposium, San Diego, Mar. 2019. Shoko Iwahashi, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Chie Takasu, Hideya Kashihara and Mitsuo Shimada :
The strategy of zero-mortality due to postoperative VTE in patients with colorectal cancer.,
ASCO-GI, San Francisco, Jan. 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.511
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.511

(DOI: 10.1200/JCO.2019.37.4_suppl.511) Masaaki Nishi, Mitsuo Shimada, Hideya Kashihara, Jun Higashijima, Kouzou Yoshikawa, Takuya Tokunaga, Tomohiko Miyatani, Chie Takasu and Shoko Iwahashi :
The impact of sidedness of colorectal cancer in tumor immunity.,
ASCO-GI, San Francisco, Jan. 2019.

(出版サイトへのリンク): ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.584
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.584

(DOI: 10.1200/JCO.2019.37.4_suppl.584) Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Mitsuo Shimada :
Transanal total mesorectal excision for rectal cancer,
第9回日本・モンゴル国際消化器癌シンポジウム, Aug. 2018. Jun Higashijima, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa :
Usefulness of indocyanine green (ICG) fluorescence system and thermography for evaluating bloodflow of intestine in laparoscopic anterior resection.,
SAGES, Seattle, Apr. 2018. Takashi Iwata, Masashi Akaike, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada :
Usefulness of the rubric evaluation as the qualitative evaluation of the laparoscopic training.,
SAGES, Seattle, Apr. 2018. Shogo Oota, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Daichi Ishikawa :
Transabdominal preperitoneal (TAPP) inguinal hernia repair with liquid-injection and gauze dissection.,
SAGES, Apr. 2018. Takuya Tokunaga, Mitsuo Shimada, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Chie Takasu, Hideya Kashihara and Daichi Ishikawa :
The Impact of Indoleamine Two to Three-Dioxygenase (IDO) Expression in Colorectal Cancer.,
SSO's 71st Annual Cancer Symposium, Chicago, Mar. 2018. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Daichi Ishikawa :
The impact of indoleamine 2,3-dioxygenase(IDO)expression on stage III gastric cancer.,
ASCO-GI, San Francisco, Jan. 2018. Daichi Ishikawa, Jun Higashijima, Chie Takasu, Hideya Kashihara, Masaaki Nishi, Takuya Tokunaga, Kouzou Yoshikawa and Mitsuo Shimada :
Preoperative chemoradiotherapy for advanced lower rectal cancer using SOX+Bev regimen and role of microRNA-223 as a predictive indicator for the responder.,
第9回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2017. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Daichi Ishikawa :
The usefulness of the OrVil method and liver mobilization for optimal surgical field in LTG.,
第9回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2017. Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Toshiaki Yoshimoto and Atsushi Takata :
Feasibility of laparoscopic gastrectomy for elderly patients.,
SAGES, Houston, Mar. 2017. Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Hideya Kashihara :
Novel prognostic factor in the colorectal cancer patients who underwent laparoscopic surgery.,
Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016. Satoru Imura, Takuya Tokunaga, Masayuki Sumitomo, Shin-ichiro Yamada, Chie Takasu, Yu Saitou, Jun Higashijima, Kouzou Yoshikawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada :
Usefulness of telementoring system to develop laparoscopic surgery in rural hospital,
Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016. Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara and Chie Takasu :
The usefulness of KI-67 index as predictive factor for the rectal cancer with preoperative chemo-radiotherapy.,
46th World Congress of Surgery (WCS)2015, Bangkok, Aug. 2015. Eto Shohei, Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada :
Relationship of programmed death 1(PD-1)expression to the recurrence in gastric cancer.,
ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2015. 江藤祥平, Takashi Iwata, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada :
Relationship of programmed death 1(PD-1)expression to the recurrence in gastric cancer.,
ASCO-GI 2015 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2014.

(キーワード): 国際学会

住友弘幸, 川上行奎, 富永景子, 吉川雅登, 石橋佳奈, 梅田穂奈美, 徳永卓哉, 山崎誠司, 安藤勤, 滝沢宏光 :
ラッププロテクターとストーマパウチを用いた簡易開窓術が症状緩和に有効であった肺癌終末期膿胸の1例,
第86回日本臨床外科学会学術集会, 2024年11月. 徳永卓哉, 脇悠平, 石橋広樹, 寺奥大貴, 山田眞一郎, 齋藤裕, 池本哲也, 森根裕二, 島田光生 :
ADSCから分化したSchwann cell-like cellが神経修復へ与える影響に関する基礎的検討,
第23回日本再生医療学会総会, 2024年3月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
胃癌腹膜播種予測におけるエクソソームmiRNAの有用性,
第96回日本胃癌学会総会, 2024年2月. 髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
局所進行胃癌に対するロボット支援手術の工夫と成績,
第96回日本胃癌学会総会, 2024年2月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
食道胃接合部腺癌に対する経裂孔ロボット支援手術,
第96回日本胃癌学会総会, 2024年2月. Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
The ingenuity of robotic surgery for advanced gastric cancer,
第96回日本胃癌学会総会, Feb. 2024. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
エクソソームmiRNAを用いての胃癌腹膜播種の予測,
第56回制癌剤適応研究会, 2024年2月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
下部直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性,
第120回日本消化器病学会四国支部例会, 2023年12月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
ロボット支援前立腺全摘後の鼠径ヘルニアに対する腹腔鏡下ヘルニア修復術についての検討,
第36回日本内視鏡外科学会総会, 2023年12月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
腹腔鏡下胃癌手術におけるトレーニングプログラムの確立,
第36回日本内視鏡外科学会総会, 2023年12月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対する経肛門的側方リンパ節郭清の手術手技と短期成績の検討,
第36回日本内視鏡外科学会総会, 2023年12月. 髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
局所進行胃癌に対するロボット支援手術の工夫と成績,
第36回日本内視鏡外科学会総会, 2023年12月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
非アルコール性脂肪肝炎に対する減量・代謝改善手術の意義,
第36回日本内視鏡外科学会総会, 2023年12月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
食道胃接合部腺癌に対するロボット手術(経裂孔アプローチ)の有用性,
第36回日本内視鏡外科学会総会, 2023年12月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性,
第36回日本内視鏡外科学会総会, 2023年12月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
胃全摘OrVil法におけるピットフォールとトラブルシューティング,
第36回日本内視鏡外科学会総会, 2023年12月. 良元俊昭, 徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
再発直腸癌に対する経肛門アプローチにおけるホログラムの有用性,
第32回日本コンピュータ外科学会大会, 2023年12月. 和田佑馬, 髙須千絵, 森根裕二, 池本哲也, 齋藤裕, 山田眞一郎, 脇悠平, 寺奥大貴, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 良元俊昭, 島田光生 :
肝細胞癌におけるエクソソームmiRNAを介したLenvatinib耐性機序の検討,
第34回日本消化器癌発生学会総会, 2023年11月. 徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
青色LEDはmetabolic couplingを抑制することで抗腫瘍効果をもたらす,
第34回日本消化器癌発生学会総会, 2023年11月. 西正暁, 和田佑馬, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
胃癌腹膜播種診断マーカーの臨床的有用性,
第34回日本消化器癌発生学会総会, 2023年11月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
大腸癌におけるImmunoscoreとフレイルの予後に与える影響,
第34回日本消化器癌発生学会総会, 2023年11月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
青色LED光による大腸癌の光受容体をターゲットとした治療法の開発,
第85回日本臨床外科学会総会, 2023年11月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
腹腔鏡下胃癌手術のトレーニングプログラム,
第85回日本臨床外科学会総会, 2023年11月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
食道胃接合部腺癌に対するロボット手術(経裂孔)の有用性,
第85回日本臨床外科学会総会, 2023年11月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
右側結腸癌に対するロボット支援下手術の可能性∼腹腔鏡手術との比較から∼,
第85回日本臨床外科学会総会, 2023年11月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
経肛門アプローチを併用したロボット支援下直腸切除術の有用性,
第85回日本臨床外科学会総会, 2023年11月. 髙須千絵, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
上部胃癌に対するロボット支援手術の工夫と成績,
第85回日本臨床外科学会総会, 2023年11月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌手術におけるMRIを用いた骨盤神経描出,
第85回日本臨床外科学会総会, 2023年11月. 柏原秀也, 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性,
第61回日本癌治療学会学術集会, 2023年10月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性,
第61回日本癌治療学会学術集会, 2023年10月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
胃癌腹膜播種特異的なエクソソーム中miRNAの同定,
第82回日本癌学会学術総会, 2023年9月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
上部胃癌に対するロボット支援胃癌手術の定型化-Left-handed LCS and pincer approach-,
第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
腸内細菌叢の変化からみた減量・代謝改善手術の効果,
第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月. 吉川幸造, 島田光生, 森根裕二, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
大建中湯の消化器疾患における役割,
第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, 2023年9月. 良元俊昭, 西正暁, 吉川幸造, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
青色LEDによる大腸癌由来CAF制御および抗腫瘍効果,
第78回日本消化器外科学会総会, 2023年7月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
エクソソームmiRNAを用いた胃癌腹膜播種の予測,
第78回日本消化器外科学会総会, 2023年7月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌手術におけるMRIを用いた骨盤神経描出,
第78回日本消化器外科学会総会, 2023年7月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下スリーブ状胃切除術後長期効果に影響を及ぼす因子に関する検討,
第78回日本消化器外科学会総会, 2023年7月. 髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
高齢者フレイル胃癌患者における術前栄養・運動介入の意義:短期成績を改善するが長期成績には寄与しない,
第78回日本消化器外科学会総会, 2023年7月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
胃全摘出術における術後パスの有用性―PSMによる解析―,
第78回日本消化器外科学会総会, 2023年7月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
進行胃癌に対するロボット支援手術の有用性,
第78回日本消化器外科学会総会, 2023年7月. 徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
経肛門アプローチを用いた拡大骨盤手術手技,
第78回日本消化器外科学会総会, 2023年7月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
大腸癌におけるFrailの意義と免疫栄養指標との関連,
日本外科代謝栄養学会第60回学術集会, 2023年7月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
胃癌術前における栄養，リハビリ介入の検討,
日本外科代謝栄養学会第60回学術集会, 2023年7月. 野間隆礼, 西正暁, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
切除不能進行胃癌に対してSOX-NIVO後Conversion手術を施行した2症例,
第44回癌免疫外科研究会, 2023年6月. 髙須千絵, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
女性消化器外科医の技術向上とキャリア育成を目指した取り組み,
日本消化器病学会四国支部第119回例会, 2023年6月. Toshihiro Nakao, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuuma Wada and Toshiaki Yoshimoto :
The Correlation of Immunoscore and Frailty in Colorectal Cancer,
第48回日本外科系連合学会学術集会, Jun. 2023. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下スリーブ状胃切除における多職種介入周術期管理の有用性,
第48回日本外科系連合学会学術集会, 2023年6月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
食道胃接合部腺癌に対するロボット支援下手術(経裂孔)の有用性,
第32回日本癌病態治療研究会, 2023年6月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
上部胃癌・食道胃接合部癌に対するロボット支援胃癌手術の手術手技,
第77回手術手技研究会, 2023年5月. 仲須千春, 西正暁, 森根裕二, 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 島田光生 :
青色LEDを用いたCAFの糖代謝に着目した腫瘍免疫制御のメカニズムの解明,
第123回日本外科学会定期学術集会, 2023年4月. 髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
高齢者フレイル胃癌患者における術前栄養・運動リハビリの意義: 短期成績を改善するが長期成績には寄与しない,
第123回日本外科学会定期学術集会, 2023年4月. 和田佑馬, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
胃癌フレイル患者における術前栄養リハビリ介入の有用性,
第123回日本外科学会定期学術集会, 2023年4月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
腸脳相関からみたMetabolic surgeryの術後早期血糖抑制効果,
第123回日本外科学会定期学術集会, 2023年4月. Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara and Toshiaki Yoshimoto :
Utility of robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: transhiatal robotic versus laparoscopic approach,
第123回日本外科学会定期学術集会, Apr. 2023. 徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 :
下部直腸癌に対する経肛門アプローチにおける術中ホログラム手術支援の有用性,
第123回日本外科学会定期学術集会, 2023年4月. 良元俊昭, 沖川昌平, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
青色LED光の腫瘍微小環境に対する効果,
第123回日本外科学会定期学術集会, 2023年4月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対するMRIを用いた骨盤神経描出,
第123回日本外科学会定期学術集会, 2023年4月. 齋藤裕, 杉本真樹, 森根裕二, 池本哲也, 徳永卓哉, 山田眞一郎, 寺奥大貴, 岩田貴, 島田光生 :
消化器外科ナビゲーションの新展開 -Extended reality・ホログラム・メタバース –,
第123回日本外科学会定期学術集会, 2023年4月. 徳永卓哉, 齋藤裕, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 :
経肛門アプローチを用いた腹腔鏡下側方郭清の手術手技と短期成績 ∼Hologramによるシミュレーションの有用性∼,
第122回日本外科学会定期学術集会, 2023年4月. 和田佑馬, 西正暁, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 島田光生 :
胃癌手術における術前栄養リハビリ介入の有用性,
第95回日本胃癌学会総会, 2023年2月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
上部胃癌・食道胃接合部癌に対するロボット手術の有用性,
第95回日本胃癌学会総会, 2023年2月. 髙須千絵, 西正暁, 和田佑馬, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
高齢者フレイル胃癌患者における術前栄養・運動介入の意義:短期成績を改善するが長期成績には寄与しない,
第95回日本胃癌学会総会, 2023年2月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
MISによる胃全摘OrVil法におけるピットフォールとトラブルシューティング,
第95回日本胃癌学会総会, 2023年2月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
下部直腸癌に対するホログラムを駆使した新たな経肛門手術,
第266回徳島医学会学術集会, 2023年2月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 島田光生 :
ロボット支援前立腺全摘後に発症した鼠径ヘルニアに対する腹腔鏡手術症例の検討,
第35回日本内視鏡外科学会総会, 2022年12月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性,
第35回日本内視鏡外科学会総会, 2022年12月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
経肛門側方リンパ節郭清の手技と短期成績 ∼ホログラムシミュレーションの有用性∼,
第35回日本内視鏡外科学会総会, 2022年12月. 徳永卓哉 :
TaTME100例の軌跡∼導入から適応拡大まで∼,
第35回日本内視鏡外科学会総会, 2022年12月. 髙須千絵, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
腹腔鏡下胃切除における6番リンパ節郭清困難性の術前予測,
第35回日本内視鏡外科学会総会, 2022年12月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
食道胃接合部癌に対するロボット支援下手術(経裂孔)の工夫,
第35回日本内視鏡外科学会総会, 2022年12月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
低侵襲胃全摘術後再建における肝臓脱転による視野確保とOrVil法の有用性,
第35回日本内視鏡外科学会総会, 2022年12月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 :
DST吻合における吻合部血流不全のリスク因子および追加切除例の検討,
第84回日本臨床外科学会総会, 2022年11月. 和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭 :
局所進行直腸癌に対する術前化学放射線療法におけるADC値の有用性,
第84回日本臨床外科学会総会, 2022年11月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性,
第84回日本臨床外科学会総会, 2022年11月. 中尾寿宏, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下結腸癌手術における体腔内吻合の短期成績,
第84回日本臨床外科学会総会, 2022年11月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
胃全摘出術における術後パスの有用性―PSMによる解析―,
第84回日本臨床外科学会総会, 2022年11月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 和田佑馬, 柏原秀也, 良元俊昭 :
上部胃癌に対するロボット支援胃癌手術の定型化- Left-handed LCS and pincer app roach –,
第84回日本臨床外科学会総会, 2022年11月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 :
他臓器浸潤を伴う直腸癌に対する経肛門アプローチの有用性,
第84回日本臨床外科学会総会, 2022年11月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性,
第118回日本消化器病学会四国支部例会, 2022年11月. 吉川幸造, 島田光生, 西正暁, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性,
第52回胃外科・術後障害研究会, 2022年11月. 西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
CAFの糖代謝を標的とした治療法の開発 -フラボノイド(EGCGとSudachitin)の可能性-,
第33回日本消化器癌発生学会総会, 2022年11月. 徳永卓哉, 良元俊昭, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 :
腫瘍関連マクロファージおよび大腸癌に対する青色LEDの効果,
第33回日本消化器癌発生学会総会, 2022年11月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
大腸癌におけるImmunoscoreとFrailの相関についての検討,
第33回日本消化器癌発生学会総会, 2022年11月. 西正暁, 髙須千絵, 森根裕二, 吉川幸造, 徳永卓哉, 和田佑馬, 中尾寿宏, 柏原秀也, 良元俊昭, 島田光生 :
漢方とBacterial translocation-大建中湯の消化管疾患に対する多面的効果の検討-,
第35回日本外科感染症学会総会学術集会, 2022年11月. 池本哲也, 徳永卓哉, 脇悠平, 寺奥大貴, 山田眞一郎, 齋藤裕, 森根裕二, 島田光生 :
Schwann-like cell分化誘導による末梢神経損傷修復に関する基礎的検討,
第60回日本癌治療学会学術集会, 2022年10月. 柏原秀也, 徳永卓哉, 島田光生 :
低位直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性,
JDDW 2022, 2022年10月. 良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 髙橋叡, 島田光生 :
大腸癌手術における予後因子としてのFrailの意義,
第60回日本癌治療学会学術集会, 2022年10月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
下部直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性,
第60回日本癌治療学会学術集会, 2022年10月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭 :
上部胃癌に対するロボット手術の工夫 Pincer approach to gastrosplenic ligament,
第60回日本癌治療学会学術集会, 2022年10月. 徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 :
ハイブリッド側方リンパ節郭清手技と短期成績∼ホログラムシミュレーションの有用性∼,
第60回日本癌治療学会学術集会, 2022年10月. 和田佑馬, 島田光生, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭 :
局所進行直腸癌における術前化学放射線療法においてADC値の有用性,
第60回日本癌治療学会学術集会, 2022年10月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 :
大腸癌におけるImmunosoreとFrailの相関,
第60回日本癌治療学会学術集会, 2022年10月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
胃全摘出術における術後パスの有用性―PSMによる解析―,
第60回日本癌治療学会学術集会, 2022年10月. 柏原秀也, 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 髙須千絵, 和田佑馬, 良元俊昭 :
下部直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性,
第77回日本大腸肛門病学会学術集会, 2022年10月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 髙橋叡 :
他臓器浸潤直腸癌に対するTpAPR手術手技,
第77回日本大腸肛門病学会学術集会, 2022年10月. 和田佑馬, 西正暁, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 島田光生 :
癌関連線維芽細胞における糖代謝に着目した治療法の可能性,
第81回日本癌学会学術総会, 2022年9月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
下部直腸癌に対するTaTME併用ロボット支援下直腸切除術(Hybrid robotic surgery)の有用性,
第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月. 西正暁, 島田光生, 吉川幸造, 和田佑馬, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
上部胃癌におけるロボット支援胃癌手術の工夫,
第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月. 髙須千絵, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 髙橋叡, 島田光生 :
腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価,
第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下結腸癌手術における体腔内吻合の短期成績,
第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月. 西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
CAFの糖代謝を標的とした治療法の開発-フラボノイド(EGCGとSudachitin)の可能性-,
第265回徳島医学会学術集会, 2022年7月. 岩川陽介, 西正暁, 和田佑馬, 島田光生, 吉川幸造, 中尾寿宏, 徳永卓哉, 髙須千絵, 柏原秀也, 良元俊昭 :
胃GISTに対するLECSの検討 -腫瘍径5㎝以上に対するLECS-,
第77回日本消化器外科学会総会, 2022年7月. 徳永卓哉, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
Hologramによるシミュレーションを用いた経肛門的側方リンパ節郭清,
第77回日本消化器外科学会総会, 2022年7月. 良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 島田光生 :
大腸癌腫瘍関連マクロファージに対する青色LEDの効果,
第77回日本消化器外科学会総会, 2022年7月. 和田佑馬, 島田光生, 西正暁, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 岩川陽介 :
腹腔鏡下胃癌手術における術前栄養リハビリ介入の有用性,
第77回日本消化器外科学会総会, 2022年7月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 :
腹腔鏡下スリーブ状胃切除術後長期効果に影響を及ぼす因子に関する検討,
第77回日本消化器外科学会総会, 2022年7月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 和田佑馬, 山下祥子 :
上部胃癌に対するロボット支援胃癌手術の工夫,
第77回日本消化器外科学会総会, 2022年7月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 :
胃癌播種診断におけるCTスコアリングシステムを用いた診断率改善の試み,
第77回日本消化器外科学会総会, 2022年7月. 齋藤裕, 杉本真樹, 森根裕二, 池本哲也, 徳永卓哉, 山田眞一郎, 寺奥大貴, 島田光生 :
術中ホログラム胆道造影を駆使した胆道手術支援,
第31回日本コンピュータ外科学会大会, 2022年6月. 徳永卓哉, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性,
第31回日本癌病態治療研究会, 2022年6月. 和田佑馬, 吉川幸造, 西正暁, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 島田光生 :
進行胃癌に対するロボット支援下胃切除術の有用性,
第117回例会日本消化器病学会四国支部, 2022年6月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 :
進行胃癌に対するロボット支援胃切除術の有用性とピットフォール,
第47回日本外科系連合学会学術集会, 2022年6月. Toshiaki Yoshimoto, Takuya Tokunaga, Yu Saitou, Hideya Kashihara, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, 山下祥子, 岩川陽介 and Mitsuo Shimada :
Intraoperative holographic image-guided lateral pelvic lymph node dissection in a transanal approach for rectal cancer,
CARS 2022, Jun. 2022. 徳永卓哉, 杉本真樹, 齋藤裕, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 島田光生 :
経肛門アプローチ併用ハイブリッド側方リンパ節郭清に対するホログラムの有用性,
第31回日本コンピュータ外科学会大会, 2022年6月. Yuuma Wada, Masaaki Nishi, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Mitsuo Shimada :
Apparent diffusion coefficient measurements predict survival outcomes after neoadjuvant chemoradiotherapy in locally advanced rectal cancer,
第67回国際外科学会日本部会総会, Jun. 2022. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
ロボット胃癌手術における工夫 -Left handed LCS techniqueとPincer approach for gastro-splenic ligament-,
第76回手術手技研究会, 2022年5月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
術前抗がん剤治療を行った進行胃癌に対する低侵襲手術の有用性,
第122回日本外科学会定期学術集会, 2022年4月. 徳永卓哉, 齋藤裕, 杉本真樹, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 :
経肛門アプローチを用いた腹腔鏡下側方郭清の手術手技と短期成績∼Hologramによるシミュレーションの有用性∼,
第122回日本外科学会定期学術集会, 2022年4月. 松崎慶仁, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭 :
ALS患者の胃癌2切除例,
第122回日本外科学会定期学術集会, 2022年4月. 和田佑馬, 西正暁, 陳術海, 森根裕二, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 :
癌関連線維芽細胞の糖代謝を標的とした治療法の開発,
第122回日本外科学会定期学術集会, 2022年4月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
大腸癌におけるImmunoscoreとフレイルの検討,
第122回日本外科学会定期学術集会, 2022年4月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
直腸癌に対するTaTME併用ロボット支援下直腸切除術の有用性 - TaTME併用腹腔鏡下直腸切除術との比較から –,
第122回日本外科学会定期学術集会, 2022年4月. 武原悠花子, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
腹腔鏡下スリーブ状胃切除における多職種介入術前減量プログラムの有用,
第122回日本外科学会定期学術集会, 2022年4月. 山下祥子, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 岩川陽介 :
直腸癌の放射線化学療法における肥満細胞の役割,
第122回日本外科学会定期学術集会, 2022年4月. 良元俊昭, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 山下祥子, 岩川陽介, 島田光生 :
青色LEDの腫瘍関連マクロファージ(TAM)および大腸癌細胞に対する効果,
第122回日本外科学会定期学術集会, 2022年4月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子 :
ロボット支援胃癌手術の短期・長期成績-ロボットvs腹腔鏡:プロペンシティスコアマッチ解析-,
第122回日本外科学会定期学術集会, 2022年4月. 髙須千絵, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子 :
腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価,
第94回日本胃癌学会総会, 2022年3月. 和田佑馬, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 :
高齢者におけるFrailtyの臨床的意義,
第94回日本胃癌学会総会, 2022年3月. Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Chie Takasu, Yuuma Wada, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Shoko Yamashita :
Propensity score-matched analysis of the short-and long-term outcomes of RG vs. LG,
第94回日本胃癌学会総会, Mar. 2022. Kouzou Yoshikawa, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Shoko Yamashita :
The usefulness of the minimal invasive surgery for advanced gastric cancer with preoperative chemotherapy,
第94回日本胃癌学会総会, Mar. 2022. 池本哲也, 徳永卓哉, 齋藤裕, 沖川昌平, 寺奥大貴, 山田眞一郎, 森根裕二, 島田光生 :
脂肪由来幹細胞から分化誘導したSchwann-like cellに関する研究,
第21回日本再生医療学会総会, 2022年3月. 髙須千絵, 森根裕二, 吉川幸造, 中尾寿宏, 西正暁, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 島田光生 :
腸管Microbiome解析からみた大建中湯の消化管疾患に対する多面的効果の検討,
第18回日本消化管学会総会学術集会(GI Week 2022), 2022年2月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 :
ロボット支援下前立腺全摘術後に発症した鼠径ヘルニアの検討,
第34回日本内視鏡外科学会総会, 2021年12月. 和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 :
腹腔鏡・ロボット支援下胃癌手術のトレーニングプログラムの構築,
第34回日本内視鏡外科学会総会, 2021年12月. 髙須千絵, 吉川幸造, 中尾寿宏, 徳永卓哉, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子, 島田光生 :
腹腔鏡下胃切除における幽門下リンパ郭清困難性の術前評価,
第34回日本内視鏡外科学会総会, 2021年12月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
NASHに対する新たな治療アプローチとしての腹腔鏡下スリーブ状胃切除術,
第34回日本内視鏡外科学会総会, 2021年12月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
ロボット支援胃癌手術の有用性,
第34回日本内視鏡外科学会総会, 2021年12月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
横行結腸・脾弯曲部・下行結腸癌における血管走行と腹腔鏡下手術手技に関する検討,
第34回日本内視鏡外科学会総会, 2021年12月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
他臓器合併切除を要する直腸癌に対するTrasaperineal abdominoperineal resection,
第34回日本内視鏡外科学会総会, 2021年12月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下スリーブ状胃切除における多職種介入周術期管理の有用性(WS5-2),
第34回日本内視鏡外科学会総会, 2021年12月. 吉川幸造, 島田光生, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
ロボット支援胃癌手術におけるLeft hand LCS techniqueを用いた定型化への取り組み(WS6-7),
第34回日本内視鏡外科学会総会, 2021年12月. 良元俊昭, 沖川昌平, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 :
青色LEDの癌関連線維芽細胞および大腸癌に対する効果,
第32回日本消化器癌発生学会総会, 2021年11月. 和田佑馬, 西正暁, 島田光生, 山下祥子, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 良元俊昭, 岩川陽介 :
直腸癌の放射線化学療法における肥満細胞の役割,
第32回日本消化器癌発生学会総会, 2021年11月. 西正暁, 島田光生, 陳述海, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
EGCGがCAFの糖代謝を標的とし，腫瘍悪性度を抑制する,
第32回日本消化器癌発生学会総会, 2021年11月. 徳永卓哉, 杉本真樹, 齋藤裕, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 島田光生 :
直腸癌に対する経肛門的アプローチにおけるホログラムと尿道造影を併用した術中ナビゲーション,
第30回日本コンピュータ外科学会大会, 2021年11月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 和田佑馬, 徳永卓哉, 中尾寿宏, 柏原秀也, 良元俊昭, 山下祥子, 岩川陽介 :
ロボット支援胃切除の有用性-Robotic Versus Laparoscopic Gastrectomy: Propensi ty-Matched Analysis.-,
第116回日本消化器病学会四国支部例会, 2021年11月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
taTMEの手術手技と治療成績,
第116回日本消化器病学会四国支部例会, 2021年11月. 岩川陽介, 西正暁, 島田光生, 吉川幸造, 中尾寿宏, 徳永卓哉, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子 :
胃原発の未分化型多形肉腫の1例,
第83回日本臨床外科学会総会, 2021年11月. 山下祥子, 西正暁, 良元俊昭, 和田佑馬, 柏原秀也, 髙須千絵, 中尾寿宏, 徳永卓哉, 吉川幸造, 常山幸一, 島田光生 :
Osteoclast-like giant cellを伴うhamartomatous inverted polypから発生したリンパ球浸潤胃癌の一例,
第83回日本臨床外科学会総会, 2021年11月. 沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介, 森根裕二 :
Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討,
第83回日本臨床外科学会総会, 2021年11月. 良元俊昭, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 山下祥子, 岩川陽介, 島田光生 :
大腸癌予後因子としてのFrailの意義,
第83回日本臨床外科学会総会, 2021年11月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
ロボット支援胃癌手術の標準化,
第83回日本臨床外科学会総会, 2021年11月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
直腸切断術に対するTransperineal approachの有用性,
第83回日本臨床外科学会総会, 2021年11月. 和田佑馬, 島田光生, 柏原秀也, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介 :
腹腔鏡下胃癌手術における術前減量プログラムの有用性,
第83回日本臨床外科学会総会, 2021年11月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 良元俊昭 :
経肛門的内視鏡下直腸間膜切除術TaTME併用による安全なロボット支援下直腸切除術の導入,
第83回日本臨床外科学会総会, 2021年11月. 中尾寿宏, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介 :
横行結腸癌における中結腸動脈の分岐からみた腹腔鏡下手術手技，治療成績,
第83回日本臨床外科学会総会, 2021年11月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 :
腹腔鏡下胃全摘OrVil法におけるピットフォールとトラブルシューティング,
第83回日本臨床外科学会総会, 2021年11月. 髙須千絵, 島田光生, 徳永卓哉, 中尾寿宏, 柏原秀也, 和田佑馬, 良元俊昭, 山下祥子, 仲須千春 :
地方だからこそ発信できるインクルージョンを目指した働き方改革,
第83回日本臨床外科学会総会, 2021年11月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 江藤祥平, 良元俊昭 :
ロボット時代の正確な腹膜播種診断に向けての胃癌Staging laparoscopyの有用性,
JDDW 2021, 2021年11月. 和田佑馬, 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 髙須千絵, 柏原秀也, 良元俊昭, 山下祥子 :
外科手術におけるFrailtyの重要性,
第51回胃外科・術後障害研究会, 2021年11月. 齋藤裕, 杉本真樹, 森根裕二, 池本哲也, 徳永卓哉, 山田眞一郎, 寺奥大貴, 岩田貴, 島田光生 :
消化器外科におけるホログラム次世代手術支援,
第30回日本コンピュータ外科学会大会, 2021年11月. 良元俊昭, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 岩川陽介, 島田光生 :
DST吻合における吻合部血流不全のリスク因子:追加切除例の検討,
第59回日本癌治療学会学術集会, 2021年10月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子 :
高齢者胃癌患者における外科手術の意義-Frailtyの重要性-,
第59回日本癌治療学会学術集会, 2021年10月. 徳永卓哉, 島田光生, 吉川幸造, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
当科におけるTaTME手術手技と治療成績,
第59回日本癌治療学会学術集会, 2021年10月. 柏原秀也, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 和田佑馬, 良元俊昭 :
腹腔鏡下胃・大腸癌手術における多職種介入術前減量プログラムの有用性,
第59回日本癌治療学会学術集会, 2021年10月. 吉川幸造, 島田光生, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
進行胃癌に対するロボット手術の有用性,
第59回日本癌治療学会学術集会, 2021年10月. 和田佑馬, 島田光生, 柏原秀也, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 山下祥子, 岩川陽介, 濵田康弘 :
肥満外科手術における術前NLRの有用性,
第27回外科侵襲とサイトカイン研究会, 2021年10月. 西正暁, 島田光生, 陳述海, 吉川幸造, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 山下祥子, 岩川陽介 :
癌関連線維芽細胞の糖代謝を標的とした治療法の開発,
第263回徳島医学会学術集会(令和3年度夏期), 2021年8月. 沖川昌平, 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 森根裕二 :
Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討,
第76回日本消化器外科学会総会, 2021年7月. 良元俊昭, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平, 島田光生 :
青色LEDの癌関連線維芽細胞および大腸癌細胞に対する効果,
第76回日本消化器外科学会総会, 2021年7月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
進行胃癌に対するロボット支援胃切除術の有用性,
第76回日本消化器外科学会総会, 2021年7月. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto :
Feasibility of hybrid robotic rectal surgery with TaTME for lower rectal cancer,
第76回日本消化器外科学会総会, Jul. 2021. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭, 江藤祥平 :
高齢者胃癌に対するFrailityの意義,
第76回日本消化器外科学会総会, 2021年7月. 髙須千絵, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也, 江藤祥平, 良元俊昭, 島田光生 :
地方外科の実情と今後のリーダー育成に向けて,
第76回日本消化器外科学会総会, 2021年7月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
直腸癌に対するTaTMEの手術手技と治療成績,
第76回日本消化器外科学会総会, 2021年7月. 仲須千春, 池本哲也, 徳永卓哉, 宮崎克己, 徳田和憲, 山田眞一郎, 齋藤裕, 居村暁, 森根裕二, 島田光生 :
脂肪由来幹細胞からSchwann-like cellの効果的分化誘導方法の研究,
第76回日本消化器外科学会総会, 2021年7月. Yu Saitou, Maki Sugimoto, Yuji Morine, Tetsuya Ikemoto, Takuya Tokunaga, Hiroki Teraoku, Katsuki Miyazaki, Takashi Iwata and Mitsuo Shimada :
Navigation of rectal and hepatobiliary pancreatic surgery with intraoperative hologram,
第76回日本消化器外科学会総会, Jul. 2021. 良元俊昭, 島田光生, 吉川幸造, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 沖川昌平, 山下祥子, 岩川陽介, 仲須千春 :
青色LEDの癌関連線維芽細胞および大腸癌細胞に対する効果,
第115回日本消化器病学会四国支部例会, 2021年6月. 吉川幸造, 島田光生, 徳永卓哉, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
腹腔鏡下胃・大腸癌手術における術前減量プログラムは短期成績改善に寄与する,
第12回日本臨床栄養代謝学会首都圏支部会学術集会, 2021年5月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 良元俊昭 :
進行胃癌に対するロボット支援下胃切除術の有用性と安全性,
第75回手術手技研究会, 2021年5月. 良元俊昭, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 島田光生 :
大腸癌予後因子としてのFrailの意義とメカニズムの検討,
第107回日本消化器病学会総会, 2021年4月. 仲須千春, 西正暁, 島田光生, 吉川幸造, 髙須千絵, 徳永卓哉, 柏原秀也, 和泉唯信, 宮本亮介 :
胃癌を発症したロックドイン状態のALS患者に対してロボット支援下胃全摘,
第121回日本外科学会定期学術集会, 2021年4月. 東島潤, 島田光生, 沖川昌平, 良元俊昭, 江藤祥平, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 吉川幸造 :
骨髄由来免疫抑制細胞を標的とした放射線治療抵抗性の制御メカニズムの解明,
第121回日本外科学会定期学術集会, 2021年4月. 良元俊昭, 島田光生, 森根裕二, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平 :
大腸癌および腫瘍微小環境に対する青色LEDの効果,
第121回日本外科学会定期学術集会, 2021年4月. 江藤祥平, 吉川幸造, 良元俊昭, 髙須千絵, 柏原秀也, 西正暁, 中尾寿宏, 徳永卓哉, 東島潤, 岩田貴, 島田光生 :
ロボット支援腹腔鏡下前立腺切除術後の鼠径ヘルニア症例に対する治療戦略,
第121回日本外科学会定期学術集会, 2021年4月. 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 江藤祥平, 良元俊昭, 島田光生 :
転移性肝癌におけるstromal PD-L1発現の意義,
第121回日本外科学会定期学術集会, 2021年4月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 江藤祥平, 良元俊昭 :
NASHに対する新たな治療アプローチとしてのmetabolic surgeryの可能性,
第121回日本外科学会定期学術集会, 2021年4月. 徳永卓哉, 島田光生, 齋藤裕, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭, 杉本真樹 :
ホログラムと術中尿道造影を駆使した経会陰的直腸切断術(TpAPR),
第121回日本外科学会定期学術集会, 2021年4月. 池本哲也, 徳永卓哉, 沖川昌平, 徳田和憲, 山田眞一郎, 齋藤裕, 居村暁, 森根裕二, 島田光生 :
脂肪由来幹細胞から分化誘導したSchwann-like cellの基礎的検討,
第20回日本再生医療学会総会, 2021年3月. Toshiaki Yoshimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara, K Yamaguchi, M Takahashi, Hiro-omi Kanayama and Mitsuo Shimada :
Surgical approach for inguinal hernia following robot-assisted radical prostatectomy,
第33回日本内視鏡外科学会, Mar. 2021. Takuya Tokunaga, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Yukako Takehara :
The Usefulness of Intraoperative Urethrography for Avoiding Urethral Injury in TpTME,
第33回日本内視鏡外科学会, Mar. 2021. Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
Usefulness of a left handed LCS technique for robotic gastrectomy,
第33回日本内視鏡外科学会, Mar. 2021. Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
The usefulness of the OrVil method in LATG,
第33回日本内視鏡外科学会, Mar. 2021. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto :
Usefulness of preoperative NLR as a predictive marker of DM remission in sleeve gastrectomy,
第33回日本内視鏡外科学会, Mar. 2021. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性,
第33回日本内視鏡外科学会, 2021年3月. Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shohei Eto, Toshiaki Yoshimoto and Yuuma Wada :
Robotic Versus Laparoscopic Gastrectomy: Propensity-Matched Analysis,
第93回日本胃癌学会総会, Mar. 2021. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
地方におけるロボット手術の定型化への試み,
第93回日本胃癌学会総会, 2021年3月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 :
肥満外科における術後体重減少・糖尿病寛解予測因子としてのNLRの有用性,
第57回日本外科代謝栄養学会学術集会, 2020年12月. 良元俊昭, 徳永卓哉, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 武原悠花子, 島田光生 :
TaTMEを安全に行うために∼術中尿道造影の有用性∼,
第45回日本外科系連合学会学術集会, 2020年12月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 良元俊昭 :
鏡視下胃癌手術のトレーニングプログラムの構築Stepwise training programの有用性,
第45回日本外科系連合学会学術集会, 2020年12月. 武原悠花子, 徳永卓哉, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 島田光生 :
DST吻合における吻合部血流不全域のリスク因子:追加切除例の検討から,
第75回日本消化器外科学会総会, 2020年12月. 髙須千絵, 西正暁, 吉川幸造, 宮谷知彦, 徳永卓哉, 柏原秀也, 良元俊昭, 武原悠花子, 島田光生 :
直腸癌CRTにおける腫瘍のIDO発現の意義,
第75回日本消化器外科学会総会, 2020年12月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 :
進行胃癌に対するロボット支援下胃切除術の有用性,
第75回日本消化器外科学会総会, 2020年12月. 徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 吉川雅登, 良元俊昭, 武原悠花子 :
TpTMEにおける前壁側剥離の工夫 ∼術中尿道造影の有用性∼,
第75回日本消化器外科学会総会, 2020年12月. 良元俊昭, 島田光生, 森根裕二, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 沖川昌平 :
青色LEDによる大腸癌の光受容体をターゲットとする治療法の開発,
第31回日本消化器癌発生学会総会, 2020年11月. 江藤祥平, 西正暁, 良元俊昭, 髙須千絵, 柏原秀也, 徳永卓哉, 中尾寿宏, 東島潤, 吉川幸造, 島田光生 :
下部進行直腸癌におけるCRT後のリンパ球CRP比(LCR)は予後不良因子となる,
第31回日本消化器癌発生学会総会, 2020年11月. Takuya Tokunaga, Mitsuo Shimada, Jun Higashijima, Kouzou Yoshikawa, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shohei Eto and Toshiaki Yoshimoto :
The Usefulness of Intraoperative Urethrography in Transperineal total Mesorectal Excision,
JDDW2020, Nov. 2020. 東島潤, 良元俊昭, 江藤祥平, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 吉川幸造, 島田光生 :
ICG蛍光法を用いた大腸癌手術成績向上のための戦略,
第82回日本臨床外科学会総会, 2020年10月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
ロボット支援胃癌手術の定型化-Left Handed LCS techniqueの有用性-,
第82回日本臨床外科学会総会, 2020年10月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 江藤祥平, 良元俊昭 :
肥満患者に対する術後合併症の回避を目指した術前減量プログラムの有用性,
第82回日本臨床外科学会総会, 2020年10月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
術中尿道造影を併用したTpAPR手術手技,
第82回日本臨床外科学会総会, 2020年10月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法―Tension free methodの有用性―,
第82回日本臨床外科学会総会, 2020年10月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
Bevacizumab使用中の消化器外科手術に関する検討,
第56回日本腹部救急医学会総会, 2020年10月. 吉川幸造, 島田光生, 徳永卓哉, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
ロボット支援下胃切除術の安全な導入と定型化,
第106回日本消化器病学会総会, 2020年8月. 良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 島田光生 :
血液透析患者に対する胃癌手術症例における予後因子の検討,
第92回日本胃癌学会総会, 2020年7月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
腹腔鏡下胃全摘OrVil法におけるピットフォールとトラブルシューティング,
第92回日本胃癌学会総会, 2020年7月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 柏原秀也, 髙須千絵 :
Left handed approach によるロボット支援下胃癌手術の有用性,
第92回日本胃癌学会総会, 2020年7月. 武原悠花子, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 島田光生 :
大腸癌におけるFrailの意義とメカニズムの検討,
第53回制癌剤適応研究会, 2020年2月. 良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 島田光生 :
Bevacizumab使用中の消化器外科手術に関する検討,
第53回制癌剤適応研究会, 2020年2月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 :
大腸癌のsidednessからみた腫瘍免疫,
第53回制癌剤適応研究会, 2020年2月. 徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 :
局所進行直腸癌に対する分子標的薬を加えた術前化学放射線療法の効果と感受性予測,
第53回制癌剤適応研究会, 2020年2月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 :
経肛門的内視鏡下直腸間膜切除術TaTME併用ロボット支援下直腸切除術の有用性,
第34回四国内視鏡外科研究会, 2020年2月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
ロボット支援下胃切除術の安全な導入と定型化,
第34回四国内視鏡外科研究会, 2020年2月. 良元俊昭, 武原悠花子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 森根裕二, 島田光生 :
LED光による新たな癌制御法の開発,
第260回徳島医学会学術集会, 2020年2月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子, 濵田康弘 :
非アルコール性脂肪肝炎(NASH)に対する新たな外科治療の開発,
第260回徳島医学会学術集会, 2020年2月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 :
Stepwise trainingとTaTME併用による安全なロボット支援下直腸切除術の導入,
第32回日本内視鏡外科学会総会, 2019年12月. 西正暁, 島田光生, 吉川幸造, 徳永卓哉, 宮谷知彦, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 :
ロボット支援胃癌手術におけるLeft handed approach の有用性,
第32回日本内視鏡外科学会総会, 2019年12月. 徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 :
TpTMEを安全に行うために ∼前壁剥離時の術中尿道造影の有用性∼,
第32回日本内視鏡外科学会総会, 2019年12月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
スリーブ状胃切除における多職種介入術前減量入院の効果,
第32回日本内視鏡外科学会総会, 2019年12月. Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu and Toshiaki Yoshimoto :
The significance of metabolic surgery in the treatment for NASH,
JDDW2019, Nov. 2019. 武原悠花子, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
大腸切除術における他職種介入SSI対策チームの有用性,
第81回日本臨床外科学会総会, 2019年11月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 武原悠花子 :
直腸癌手術におけるICG蛍光法・サーモグラフィによる血流評価を用いた縫合不全回避対策,
第81回日本臨床外科学会総会, 2019年11月. 西正暁, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 髙須千絵, 良元俊昭, 武原悠花子 :
ロボット支援下胃癌手術におけるLeft handed approach の有用性,
第81回日本臨床外科学会総会, 2019年11月. 良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 森根裕二, 島田光生 :
光受容体Opsin3をターゲットとした青色LEDの大腸癌抑制効果,
第81回日本臨床外科学会総会, 2019年11月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
地方から発信する腹腔鏡技術認定医取得への教育プログラム,
第81回日本臨床外科学会総会, 2019年11月. 良元俊昭, 西正暁, 武原悠花子, 柏原秀也, 髙須千絵, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 :
大腸癌のsidednessからみた腫瘍免疫,
第30回日本消化器癌発生学会総会, 2019年11月. 徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子, 宮崎克己 :
下部直腸癌に対する経肛門的アプローチ(TaTME)∼術中尿道造影の有用性∼,
第112回日本消化器病学会四国支部例会, 2019年11月. 吉川幸造, 島田光生, 柏原秀也, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭, 濵田康弘, 吉田守美子 :
スリーブ状胃切除における術前減量入院の効果とNLRによる術後減量効果予測,
第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月. 武原悠花子, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
腹腔鏡下胃切除術における術前減量プログラムの有用性,
第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 :
NASH治療におけるMetabolic surgeryの意義,
第40回日本肥満学会第37回日本肥満症治療学会学術集会, 2019年11月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
胃癌に対するロボット手術の有用性,
第57回日本癌治療学会学術集会, 2019年10月. 良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子, 森根裕二, 島田光生 :
光受容体Opn3を介した青色LEDの大腸癌抑制効果,
第57回日本癌治療学会学術集会, 2019年10月. 良元俊昭, 島田光生, 西正暁, 柏原秀也, 髙須千絵, 徳永卓哉, 宮谷知彦, 吉川幸造 :
光受容体Opn3を介した青色LED光の大腸癌抑制効果,
第78回日本癌学会学術総会, 2019年9月. 武原悠花子, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 良元俊昭 :
GISTとの鑑別を要したデスモイド型線維腺腫症の一例,
第71回日本消化器画像診断研究会, 2019年9月. 良元俊昭, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 武原悠花子 :
術前診断が困難であった成人小腸重複腸管の1例,
第71回日本消化器画像診断研究会, 2019年9月. 良元俊昭, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 島田光生 :
Bevacizumab使用中の消化器外科手術に関する検討,
第74回日本消化器外科学会総会, 2019年7月. 西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 和田佑馬, 良元俊昭 :
Left handed approach によるロボット支援下胃癌手術,
第74回日本消化器外科学会総会, 2019年7月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
VR+AR実習は学生の腹腔鏡模擬手術実習における局所解剖理解に有用である,
第74回日本消化器外科学会総会, 2019年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 :
スリーブ状胃切除における術前NLRと糖尿病改善についての検討,
第74回日本消化器外科学会総会, 2019年7月. 髙須千絵, 島田光生, 岩田貴, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 良元俊昭 :
女性消化器外科医の技術向上とキャリア育成を目指した取り組み,
第74回日本消化器外科学会総会, 2019年7月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
Urethrography navigationを用いたTpTME手術手技,
第74回日本消化器外科学会総会, 2019年7月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性―合併症ゼロを目指した工夫―,
第74回日本消化器外科学会総会, 2019年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 :
スリーブ状胃切除における多職種介入術前減量入院の効果とNLRによる術後減量効果,
日本外科代謝栄養学会第56回学術集会, 2019年7月. 西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 良元俊昭 :
Left handed approachによるロボット支援下胃癌手術,
第111回日本消化器病学会四国支部例会, 2019年6月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 岩橋祥子 :
大腸癌手術における周術期VTE予防マネジメント,
第44回日本外科系連合学会学術集会, 2019年6月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
学生の腹腔鏡模擬手術実習における局所解剖理解に対するVR+ARの有用性について,
第44回日本外科系連合学会学術集会, 2019年6月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 :
ガーゼ剥離と膨潤TAPPを用いた腹腔鏡手術教育システムの有効性,
第17回日本ヘルニア学会学術集会, 2019年5月. 徳永卓哉, 島田光生, 東島潤, 吉川幸造, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
TpTMEにおける前壁剥離時の術中尿道造影の有用性,
第73回手術手技研究会, 2019年5月. 仲須千春, 西正暁, 島田光生, 岩橋祥子, 池本哲也, 東島潤, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 良元俊昭 :
大腸癌手術における周術期VTE予防マネジメント,
第119回日本外科学会定期学術集会, 2019年4月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
直腸切断術におけるTaTMEの工夫 ∼尿道損傷回避のための術中尿道造影の有用性∼,
第119回日本外科学会定期学術集会, 2019年4月. 東島潤, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
側方転移を有する進行下部直腸癌に対する術前CRT+側方郭清の功罪,
第119回日本外科学会定期学術集会, 2019年4月. 宮谷知彦, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 和田佑馬, 太田昇吾, 岩橋祥子 :
直腸癌手術におけるICG蛍光法による血流評価の有用性と定量化,
第119回日本外科学会定期学術集会, 2019年4月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
Step-wise trainingシステムによる安全なロボット支援胃切除導入の取り組み,
第119回日本外科学会定期学術集会, 2019年4月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 :
スリーブ状胃切除における多職種介入術前減量入院の効果とNLRによる術後減量効果予測,
第119回日本外科学会定期学術集会, 2019年4月. 西正暁, 島田光生, 髙須千絵, 東島潤, 吉川幸造, 宮谷知彦, 徳永卓哉, 柏原秀也 :
大腸癌におけるsidednessからみた腫瘍免疫機構,
第119回日本外科学会定期学術集会, 2019年4月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
学生の腹腔鏡実習における局所解剖理解のためのVR実習の検討,
第119回日本外科学会定期学術集会, 2019年4月. 良元俊昭, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 森根裕二, 島田光生 :
大腸癌に対する青色LED光の光受容体を介した抗腫瘍効果,
第52回制癌剤適応研究会, 2019年3月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 濵田康弘 :
腹腔鏡下胃切除術における多職種介入術前減量プログラムの有用性,
第91回日本胃癌学会総会, 2019年2月. Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu and Toshiaki Yoshimoto :
The usefulness of our step-wise training system for robotic assisted gastrectomy.,
第91回日本胃癌学会総会, Feb. 2019. 西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 宮谷知彦, 徳永卓哉, 髙須千絵, 良元俊昭, 和田佑馬 :
腹腔鏡下胃癌手術のトレーニングプログラムの構築,
第91回日本胃癌学会総会, 2019年2月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
TaTMEにおける尿道損傷回避のための工夫 ∼術中尿道造影の有用性∼,
第33回四国内視鏡外科研究会, 2019年2月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
Step-wise trainingシステムによる安全なロボット支援下胃切除導入の取り組み,
第33回四国内視鏡外科研究会, 2019年2月. 西正暁, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 髙須千絵, 柏原秀也, 和田佑馬, 良元俊昭 :
安全なロボット支援下胃癌手術の再導入,
第2回徳島外科医会, 2019年2月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 :
腹腔鏡下胃切除術における肥満症例に対する取り組み∼術前減量プログラムの効果∼,
第31回日本内視鏡外科学会総会, 2018年12月. 髙須千絵, 島田光生, 岩田貴, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也 :
内視鏡外科技術向上を目指した総合的トレーニング法の効果,
第31回日本内視鏡外科学会総会, 2018年12月. 東島潤, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 :
腹腔鏡下前方切除術における縫合不全回避のためのICG蛍光法とサーモグラフィーによる血流評価の有用性,
第31回日本内視鏡外科学会総会, 2018年12月. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 :
腹腔鏡下の局所解剖理解のためのVR実習と質的評価としてのルーブリック評価の検討,
第31回日本内視鏡外科学会総会, 2018年12月. 西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 宮谷知彦 :
腹腔鏡下胃癌手術のトレーニングプログラムの構築,
第31回日本内視鏡外科学会総会, 2018年12月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
腹腔鏡手術におけるノンテクニカルスキル評価法の開発,
第31回日本内視鏡外科学会総会, 2018年12月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
TaTMEにおける尿道損傷回避のための術中尿道造影の有用性,
第31回日本内視鏡外科学会総会, 2018年12月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 :
ガーゼ剥離と膨潤TAPPを用いた腹腔鏡手術教育システムの有効性,
第80回日本臨床外科学会総会, 2018年11月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 宮谷知彦 :
腹腔鏡下胃癌手術のトレーニングプログラムの構築-Road to white surgery-,
第80回日本臨床外科学会総会, 2018年11月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
胃癌に対するConversion surgeryの有用性,
第80回日本臨床外科学会総会, 2018年11月. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
安全な中心静脈カテーテル(CVC)留置を目指したトレーニングシステムの構築・取組み・評価について,
第80回日本臨床外科学会総会, 2018年11月. 東島潤, 良元俊昭, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 島田光生 :
Crohn's disease の外科治療成績について -Kono-S吻合の有用性-,
第110回日本消化器病学会四国支部例会, 2018年11月. 東島潤, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
大腸癌におけるmicroRNA-449a発現の意義,
第29回日本消化器癌発生学会総会, 2018年11月. 柏原秀也, 良元俊昭, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 森根裕二, 島田光生 :
大腸癌に対する青色LED光の効果と光受容体の関与についての研究,
第29回日本消化器癌発生学会総会, 2018年11月. 岩橋祥子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 東島潤, 吉川幸造, 常山幸一, 島田光生 :
Osteoclast-like giant cellを伴うhamartomatous inverted polypから発生したリンパ球浸潤胃癌の一例,
第29回日本消化器癌発生学会総会, 2018年11月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 :
CKLF like MARVEL transmembrane domain containing 6(CMTM6)を介した胃癌再発機構,
JDDW2018, 2018年11月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
腹腔鏡下胃切除術における術前減量プログラムの効果,
JDDW2018, 2018年11月. 徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 宮谷知彦 :
直腸縫合不全回避のためのICG蛍光法・サーモグラフィーを用いた血流評価の有用性,
JDDW2018, 2018年11月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略,
第56回日本癌治療学会学術集会, 2018年10月. 西正暁, 島田光生, 髙須千絵, 柏原秀也, 吉川幸造, 東島潤, 石川大地, 徳永卓哉, 和田佑馬, 宮谷知彦 :
胃癌におけるCMTM6発現の意義,
第56回日本癌治療学会学術集会, 2018年10月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
腹腔鏡下前方切除術におけるICG蛍光法・サーモグラフィーによる血流評価の有用性,
第56回日本癌治療学会学術集会, 2018年10月. 吉川幸造, 島田光生, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
Metabolic surgeryのNASH改善メカニズムに関する研究,
第27回消化器疾患病態治療研究会, 2018年9月. 太田昇吾, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
NLRを用いた胃癌における再建術式別栄養・免疫機能評価,
第73回日本消化器外科学会総会, 2018年7月. 石川大地, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 東島潤, 吉川幸造, 島田光生 :
再発及び前立腺摘出術後の鼠径ヘルニア症例に対するTAPP法の有用性,
第73回日本消化器外科学会総会, 2018年7月. 髙須千絵, 岩田貴, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 柏原秀也, 石川大地, 島田光生 :
大健中湯は小腸パイエル版のPD-1発現を介してバクテリアルトランスロケーション発症を予防する可能性がある,
第73回日本消化器外科学会総会, 2018年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
Metabolic surgeryのNASH改善メカニズムに関する研究,
第73回日本消化器外科学会総会, 2018年7月. 西正暁, 島田光生, 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 石川大地, 和田佑馬 :
CMTM6による胃癌再発機構の解明,
第73回日本消化器外科学会総会, 2018年7月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 :
TaTMEにおける尿道損傷回避のための工夫,
第73回日本消化器外科学会総会, 2018年7月. 東島潤, 島田光生, 石川大地, 髙須千絵, 柏原秀也, 西正暁, 徳永卓哉, 吉川幸造, 柏原秀也 :
局所進行下部直腸癌に対する術前化学放射線療法を用いた新たな治療戦略 ~Watch and wait導入へ向けて~,
第73回日本消化器外科学会総会, 2018年7月. 吉川幸造, 島田光生, 沖津宏, 江藤祥平, 富林敦司, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略,
第73回日本消化器外科学会総会, 2018年7月. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
ルーブリック評価を用いた腹腔鏡トレーニングの質的評価と局所解剖理解のためのVR実習の検討,
第73回日本消化器外科学会総会, 2018年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵 :
胃癌におけるCMTM6発現の意義,
第25回外科侵襲とサイトカイン研究会, 2018年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
肥満患者に対する腹腔鏡下胃切除術における術前減量プログラムの効果,
第43回日本外科系連合学会学術集会, 2018年6月. 徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
TaTMEにおける尿道損傷回避のための工夫,
第43回日本外科系連合学会学術集会, 2018年6月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
大腸癌におけるmicroRNA-449a発現の意義,
第27回日本癌病態治療研究会, 2018年5月. 東島潤, 島田光生, 森根裕二, 居村暁, 池本哲也, 吉川幸造, 森大樹, 徳永卓哉, 西正暁, 岩橋衆一, 齋藤裕, 柏原秀也, 髙須千絵, 矢田圭吾 :
Academic surgeon 育成のための新たな研修への取り組み―大学病院と市中病院の新たな連携―,
第36回臨床研修研究会, 2018年4月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地, 和田佑馬 :
肥満手術のインスリン抵抗性・NASH改善効果におけるマイクロバイオームの重要性,
第104回日本消化器病学会総会, 2018年4月. 石川大地, 髙須千絵, 柏原秀也, 徳永卓哉, 東島潤, 吉川幸造, 髙須千絵, 島田光生 :
胃癌組織中に発現するmicroRNA-449aの意義解明についての研究,
第118回日本外科学会定期学術集会, 2018年4月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
肥満患者に対する腹腔鏡下胃・大腸切除術における術前減量プログラムの効果,
第118回日本外科学会定期学術集会, 2018年4月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
腹腔鏡下胃全摘出術の食道空腸吻合法におけるOrVil法の有用性,
第118回日本外科学会定期学術集会, 2018年4月. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 赤池雅史 :
腹腔鏡トレーニングの質的評価としてのルーブリック評価の有用性の検討,
第118回日本外科学会定期学術集会, 2018年4月. 髙須千絵, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 石川大地 :
大腸癌におけるPD-1/PDL-1発現の意義,
第118回日本外科学会定期学術集会, 2018年4月. 岩橋祥子, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 石川大地, 三木浩和, 大浦雅博 :
MDS・発作性夜間血色素尿症を合併する胃癌に対する手術が安全に施行可能であった1例,
第118回日本外科学会定期学術集会, 2018年4月. 太田昇吾, 島田光生, 西正暁, 徳永卓哉, 東島潤, 石川大地, 吉川幸造, 髙須千絵, 柏原秀也, 森根裕二 :
ICG蛍光システムを用いたTaTMEにおける尿道損傷回避に向けた取り組み,
第118回日本外科学会定期学術集会, 2018年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地, 和田佑馬 :
腫瘍免疫からみた大腸癌再発機構の解明,
第118回日本外科学会定期学術集会, 2018年4月. 徳永卓哉, 島田光生, 東島潤, 吉川幸造, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 :
腹腔鏡下前方切除術におけるICG蛍光法・サーモグラフィーによる血流評価の有用性,
第118回日本外科学会定期学術集会, 2018年4月. 東島潤, 島田光生, 太田昇吾, 石川大地, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 吉川幸造 :
局所進行直腸癌に対する分子標的薬を加えた術前化学放射線療法の効果と感受性予測:基礎的検討と臨床成績,
第118回日本外科学会定期学術集会, 2018年4月. 石川大地, 髙須千絵, 柏原秀也, 徳永卓哉, 西正暁, 東島潤, 吉川幸造, 島田光生 :
大腸癌の発癌・癌進展におけるmicroRNA-449aの役割解明,
第51回制癌剤適応研究会, 2018年3月. 吉川幸造, 島田光生, 東島潤, 沖津宏, 江藤祥平, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
StageIV胃癌に対するConversion surgeryにおける問題点と治療戦略,
第51回制癌剤適応研究会, 2018年3月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
肥満患者に対する腹腔鏡下胃切除術における術前減量プログラム,
第90回日本胃癌学会総会, 2018年3月. 西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 石川大地 :
LECS for GIST -single center experience-,
第90回日本胃癌学会総会, 2018年3月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
The usefulness of the OrVil method and liver mobilization for optimal surgical field in LATG.,
第90回日本胃癌学会総会, 2018年3月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
鼠径ヘルニア再発症例に対するTAPP法の有用性,
第32回四国内視鏡研究会, 2018年2月. 東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 和田佑馬, 太田昇吾 :
当科におけるTaTMEの導入について,
第32回四国内視鏡研究会, 2018年2月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
肥満に対する腹腔鏡下Sleeve状胃切除の経験,
第32回四国内視鏡研究会, 2018年2月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
ガーゼ剥離を用いた膨潤TAPP―再発症例より学至適剥離・メッシュ展開―,
第30回日本内視鏡外科学会総会, 2017年12月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
腹腔鏡下腹壁瘢痕ヘルニア根治術に対するHybrid法の有用性,
第30回日本内視鏡外科学会総会, 2017年12月. 東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
腹腔鏡下大腸手術における縫合不全回避のための血流評価の重要性,
第30回日本内視鏡外科学会総会, 2017年12月. 徳永卓哉, 髙須千絵, 石川大地, 柏原秀也, 西正暁, 東島潤, 吉川幸造, 島田光生 :
Hybrid法を用いた腹腔鏡下腹壁瘢痕ヘルニア根治術の安全性と有用性,
第79回日本臨床外科学会総会, 2017年11月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
ガーゼ剥離を用いた膨潤TAPP,
第79回日本臨床外科学会総会, 2017年11月. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
腹腔鏡実習におけるルーブリック評価を用いた質的評価の検討,
第79回日本臨床外科学会総会, 2017年11月. 東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
下部直腸癌に対するCRT効果予測因子としてのmiR223の意義,
第28回日本消化器癌発生学会総会, 2017年11月. 西正暁, 島田光生, 石川大地, 髙須千絵, 徳永卓哉, 柏原秀也, 東島潤, 吉川幸造 :
IDOによる免疫能と胃癌転移機構の解明,
第28回日本消化器癌発生学会総会, 2017年11月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地, 徳永卓哉 :
胃GISTに対する腹腔鏡・内視鏡合同手術(LECS)の検討,
第108回日本消化器病学会四国支部例会, 2017年11月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 :
The impact of Indoleaine 2,3-dioxygenase (IDO) expression in stagelll gastric cancer,
第55回日本癌治療学会学術集会, 2017年10月. 徳永卓哉, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
地方におけるロボット手術の現状について,
第92回中国四国外科学会総会, 2017年9月. 岩橋祥子, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也, 石川大地, 髙田厚史, 良元俊昭, 太田昇吾 :
術前診断が困難であった胃粘膜下異所性胃腺の1例,
第255回徳島医学会学術集会, 2017年8月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 :
肥満手術は町内最近叢変化を介して腸管炎症を抑制しインスリン抵抗性やNASH改善に寄与する,
第72回日本消化器外科学会総会, 2017年7月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地, 良元俊昭, 髙田厚史 :
下部直腸癌のCRT後NLRは予後不良因子になる,
第72回日本消化器外科学会総会, 2017年7月. 東島潤, 島田光生, 吉川幸造, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地 :
下部直腸癌に対するCRT効果予測因子としてのmiR223の意義,
第87回大腸癌研究会, 2017年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 :
腹腔鏡下胃切除術における肥満の影響と治療成績改善への取り組み,
日本外科代謝栄養学会第54回学術集会, 2017年7月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 石川大地 :
外科診療における外来インフォームドコンセント導入の試み,
第42回日本外科系連合学会学術集会, 2017年6月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也, 髙須千絵, 石川大地 :
腹腔鏡下胃癌手術における吻合法の工夫,
第42回日本外科系連合学会学術集会, 2017年6月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 髙須千絵, 石川大地 :
ガーゼ剥離を用いた膨潤TAPPの有用性,
第71回手術手技研究会, 2017年5月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地 :
腹腔鏡下胃癌手術における吻合術・視野展開の工夫,
第71回手術手技研究会, 2017年5月. 西正暁, 島田光生, 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 柏原秀也 :
IDOによる免疫能と胃癌転移機構,
第117回日本外科学会定期学術集会, 2017年4月. 西正暁, 島田光生, 吉川幸造, 柏原秀也, 東島潤, 徳永卓哉, 髙須千絵, 石川大地 :
超高齢者に対する腹腔鏡下胃切除は安全に施行可能か?,
第103回日本消化器病学会総会, 2017年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 柏原秀也, 徳永卓哉, 髙須千絵, 石川大地, 髙田厚史, 良元俊昭 :
Indoleamine 2,3-dioxygenase(IDO)による胃癌再発機構,
第50回制癌剤適応研究会, 2017年3月. 西正暁, 島田光生, 吉川幸造, 髙須千絵, 東島潤, 徳永卓哉, 柏原秀也, 石川大地 :
IDOによる胃癌再発機構の解明,
第89回日本胃癌学会総会, 2017年3月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 髙須千絵, 柏原秀也, 石川大地, 髙田厚史, 良元俊昭 :
術前診断が困難であった胃粘膜下異所性胃腺の1例,
第66回日本消化器画像診断研究会, 2017年2月. 西正暁, 東島潤, 石川大地, 柏原秀也, 髙須千絵, 徳永卓哉, 吉川幸造 :
下部直腸癌に対するCRT効果予測因子としてのmiR-223の意義,
第13回日本消化管学会総会学術集会, 2017年2月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵 :
結腸切除術におけるDVTリスク評価とVTE予防,
第25回徳島外科術後管理研究会, 2017年2月. 東島潤, 島田光生, 發知将規, 八木淑之, 沖津宏, 三浦連人, 坂東儀昭, 三宅秀則, 徳永卓哉, 石川正志, 福山充俊, 和田大助 :
大腸癌患者において化学療法がQOL，夜間睡眠へ及ぼす影響についての検討,
第54回日本癌治療学会学術集会, 2016年10月. 柏原秀也, 髙須千絵, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙田厚史, 良元俊昭, 島田光生 :
IDOによる免疫能と大腸癌転移機構,
第27回日本消化器癌発生学会総会, 2016年9月. 居村暁, 徳永卓哉, 東島潤, 吉川幸造, 森根裕二, 島田光生, 住友正幸 :
へき地病院から専門医を輩出するための地域外科診療部の役割,
第71回日本消化器外科学会総会, 2016年7月. 良元俊昭, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 徳永卓哉, 寺奥大貴, 吉川雅登, 髙田厚史, 島田光生 :
直腸癌術前CRT症例におけるKi-67，Survivin発現の意義,
第116回日本外科学会定期学術集会, 2016年4月. 小山啓介, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
スリーブ状胃切除におけるGlucagon-like peptide-1の増加は耐糖能異常・脂肪肝の改善に寄与する.,
第116回日本外科学会定期学術集会, 2016年4月. 髙須千絵, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也 :
IDOによる免疫能と大腸癌肝転移機構.,
第116回日本外科学会定期学術集会, 2016年4月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
Roux en Y再建は術後早期より耐糖能異常を改善する.,
第116回日本外科学会定期学術集会, 2016年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵, 寺奥大貴, 吉川雅登, 良元俊昭 :
膵癌細胞におけるResveratrolのShh pathwayを介した細胞増殖抑制効果,
第116回日本外科学会定期学術集会, 2016年4月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 寺奥大貴, 吉川雅登, 良元俊昭, 髙田厚史 :
進行大腸癌に対する新たな予後予測因子の検討.,
第116回日本外科学会定期学術集会, 2016年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 柏原秀也, 髙須千絵, 徳永卓哉 :
胃癌におけるPD-1/PD-L1発現の意義.,
第49回制癌剤適応研究会, 2016年3月. 柏原秀也, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
手技の定型化による腹腔鏡下鼠径ヘルニア修復術の標準化への試み,
第30回四国内視鏡外科研究会, 2016年2月. 吉川幸造, 島田光生, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
腹腔鏡補助下胃全摘術の食道空腸吻合法におけるOrvil法の有用性と再建の工夫,
第30回四国内視鏡外科研究会, 2016年2月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵 :
胃癌におけるPD1/PDL1発現の意義,
第252回徳島医学会学術集会, 2016年2月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 柏原秀也 :
進行大腸癌におけるFbxw7発現は再発予後規定因子となりうる,
第84回大腸癌研究会, 2016年1月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵 :
胃癌におけるPD-1/PD-L1発現の意義,
第22回外科侵襲とサイトカイン研究会, 2015年12月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
手技の定型化により腹腔鏡下鼠径ヘルニア手術の標準化は可能である,
第28回日本内視鏡外科学会総会, 2015年12月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
進行大腸癌に対する腹腔鏡手術vs開腹手術のpropensity scoreによる検討,
第28回日本内視鏡外科学会総会, 2015年12月. 吉川幸造, 島田光生, 東島潤, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 徳永卓哉 :
腹腔鏡補助下胃全摘術の食道空腸吻合法におけるOrVil法の有用性と再建の工夫,
第28回日本内視鏡外科学会総会, 2015年12月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 徳永卓哉, 髙須千絵, 柏原秀也 :
手術シミュレーションを利用した鏡視下手技が苦手な学生の同定とトレーニングの工夫,
第28回日本内視鏡外科学会総会, 2015年12月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
Glasgow prognostic score(GPS)を用いた腹腔鏡下進行大腸癌手術における予後予測の検討,
第77回日本臨床外科学会総会, 2015年11月. 西正暁, 島田光生, 東島潤, 吉川幸造, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵 :
直腸癌手術における縫合不全回避のための術中血流評価の有用性,
第24回日本コンピュータ外科学会大会, 2015年11月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
非癌部Thrombospondin-1(THBS1)発現は胃発癌に関連する,
第26回日本消化器癌発生学会総会, 2015年11月. 東島潤, 島田光生, 岩田貴, 吉川幸造, 徳永卓哉, 柏原秀也, 髙須千絵 :
局所進行下部直腸癌に対する多剤併用術前化学放射線療法,
第70回日本大腸肛門病学会学術集会, 2015年11月. 柏原秀也, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
肥満患者に対するスリーブ状胃切除術の有用性に関する検討,
日本消化器病学会四国支部第104回例会, 2015年11月. 東島潤, 中尾寿宏, 西正暁, 柏原秀也, 髙須千絵, 徳永卓哉, 良元俊昭, 髙田厚史, 島田光生 :
直腸癌術前CRT症例におけるKi-67発現の意義,
第53回日本癌治療学会学術集会, 2015年10月. 柏原秀也, 島田光生, 岩田貴, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
TGFβを介した腫瘍免疫機構は治癒切除した胃癌再発に関与する,
第53回日本癌治療学会学術集会, 2015年10月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵 :
StageII/III大腸癌における腹腔鏡手術vs開腹手術のpropensity scoreによる検討,
第53回日本癌治療学会学術集会, 2015年10月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵, 江藤祥平 :
胃癌におけるPD-1発現の意義,
第74回日本癌学会学術総会, 2015年10月. 中尾寿宏, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平 :
StageII/III大腸癌腹腔鏡手術と開腹手術のpropensity scoreによる検討,
JDDW 2015, 2015年10月. 西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 中尾寿宏, 髙須千絵, 江藤祥平 :
腹腔鏡下胃切除における3Dシミュレーションとナビゲーション,
第70回日本消化器外科学会総会, 2015年7月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 徳永卓哉, 髙須千絵, 江藤祥平, 赤池雅史 :
内視鏡手術時代における卒前教育からのoff-the-jobと反転授業を応用した実習の試み,
第70回日本消化器外科学会総会, 2015年7月. 居村暁, 徳永卓哉, 東島潤, 吉川幸造, 森根裕二, 住友正幸, 島田光生 :
へき地病院から専門医を輩出するための地域外科診療部の活用,
第70回日本消化器外科学会総会, 2015年7月. 東島潤, 島田光生, 岩田貴, 吉川幸造, 中尾寿宏, 徳永卓哉, 西正暁, 髙須千絵 :
切除可能大腸癌肝転移に対する原発・転移巣同時切除の妥当性,
第83回大腸癌研究会, 2015年7月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 柏原秀也, 髙須千絵, 江藤祥平 :
LED光照射による癌幹細胞制御に関する研究,
第24 回日本癌病態治療研究会, 2015年6月. 中尾寿宏, 島田光生, 岩田貴, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平 :
腹腔鏡下大腸癌手術におけるICG蛍光法の有用性,
第69回手術手技研究会, 2015年5月. 江藤祥平, 島田光生, 岩田貴, 吉川幸造, 東島潤, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵 :
胃癌におけるPD-1,THBS1発現は再発と関係する,
第115回日本外科学会定期学術集会, 2015年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 髙須千絵, 江藤祥平, 寺奥大貴 :
膵癌細胞におけるResveratrolの autophagyを介した細胞増殖抑制効果,
第115回日本外科学会定期学術集会, 2015年4月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 徳永卓哉, 髙須千絵, 赤池雅史 :
鏡視下手技が苦手な学生をどうトレーニングするか?―off-the-job トレーニングの工夫―,
第115回日本外科学会定期学術集会, 2015年4月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 髙須千絵, 江藤祥平, 寺奥大貴, 岩田貴, 和田大助, 坂東儀昭, 尾形信也, 柏原秀也, 栗田信浩, 徳永卓哉 :
術前3Dシュミュレーションを用いた腹腔鏡下胃切除,
第87回日本胃癌学会総会, 2015年3月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 髙須千絵, 江藤祥平, 寺奥大貴 :
腹腔鏡下胃切除における術前3Dシミュレーションの有用性,
第29回四国内視鏡外科研究会, 2015年2月.

(キーワード): 国内学会

髙須千絵, 西正暁, 岩田貴, 東島潤, 吉川幸造, 中尾寿宏, 徳永卓哉, 江藤祥平, 島田光生 :
肥満患者に対するスリーブ状胃切除術の成績,
第76回日本臨床外科学会総会, 2014年11月.

(キーワード): 国内学会

西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 中尾寿宏, 柏原秀也, 髙須千絵, 江藤祥平 :
若手外科医のための腹腔鏡下胃切除における術前3Dシミュレーションの有用性,
第76回日本臨床外科学会総会, 2014年11月.

(キーワード): 国内学会

江藤祥平, 吉川幸造, 岩田貴, 東島潤, 徳永卓哉, 中尾寿宏, 西正暁, 髙須千絵, 島田光生 :
大腸癌細胞におけるCD47抑制と放射線増感効果の検討,
第102回日本消化器病学会四国支部例会, 2014年11月.

(キーワード): 国内学会

西正暁, 島田光生, 栗田信浩, 吉川幸造, 東島潤, 中尾寿宏, 徳永卓哉, 髙須千絵, 江藤祥平 :
胃GISTに対する腹腔鏡・内視鏡合同手術(LECS)の検討,
第22回日本消化器関連学会週間(JDDW), 2014年10月.

(キーワード): 国内学会

西正暁, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 中尾寿宏, 髙須千絵, 江藤祥平 :
腹腔鏡下胃切除における術前3Dシュミュレーションの有用性,
第27回日本内視鏡外科学会総会, 2014年10月.

(キーワード): 国内学会

岩田貴, 島田光生, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 髙須千絵, 江藤祥平, 中尾寿宏, 赤池雅史 :
内視鏡外科手術におけるOff-the-jobトレーニングを科学する,
第27回日本内視鏡外科学会総会, 2014年10月.

(キーワード): 国内学会

西正暁, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 近清素也, 徳永卓哉, 柏原秀也, 松本規子, 江藤祥平, 髙須千絵 :
胃癌発癌におけるThrombospondin-1(THBS1)発現の意義,
第52回日本癌治療学会学術集会, 2014年8月.

(キーワード): 国内学会

岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 徳永卓哉, 柏原秀也 :
内視鏡外科手術のさらなる発展に向けたoff-the-jobとon-the-jobトレーニングの検討,
第69回日本消化器外科学会総会, 2014年7月.

(キーワード): 国内学会

岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 徳永卓哉, 中尾寿宏 :
卒前・卒後の内視鏡外科手術教育におけるトレーニングの検討,
第39回日本外科系連合学会学術集会, 2014年6月.

(キーワード): 国内学会

西正暁, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 近清素也, 徳永卓哉, 柏原秀也, 髙須千絵, 松本規子, 江藤祥平 :
肥満患者に対するスリーブ状胃切除術の成績,
第101回日本消化器病学会四国支部例会, 2014年6月.

(キーワード): 国内学会

徳永卓哉, 安藤勤, 島田光生, 岩田貴, 佐藤宏彦, 吉川幸造, 近清素也, 西正暁, 柏原秀也 :
地域外科医療を支えるための工夫∼Telementoring systemの導入・有用性∼,
第114回日本外科学会定期学術集会, 2014年4月. 西正暁, 島田光生, 栗田信浩, 吉川幸造, 柏原秀也, 佐藤宏彦, 東島潤, 近清素也, 徳永卓哉, 松本規子, 江藤祥平 :
リスクファクターを有する腹腔鏡下胃切除は安全に施工可能か?,
第86回日本胃癌学会総会, 2014年3月. 西正暁, 島田光生, 佐藤宏彦, 栗田信浩, 吉川幸造, 東島潤, 近清素也, 徳永卓哉, 柏原秀也, 髙須千絵, 松本規子, 江藤祥平 :
局所進行下部直腸癌に対するS-1/Oxaliplatin/Bevacizumab併用術前CRTと，S-1，UFT併用術前CRTと比較検討,
第47回制癌剤適応研究会, 2014年3月. 西正暁, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 髙須千絵, 江藤祥平, 寺奥大貴, 岩田貴, 和田大助, 坂東儀昭, 尾方信也, 柏原秀也, 栗田信浩, 徳永卓哉 :
術前3Dシュミュレーションを用いた腹腔鏡下胃切除,
第87回日本胃癌学会総会, 2014年3月.

(キーワード): 国内学会

岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 柏原秀也, 松本規子, 徳永卓哉, 赤池雅史 :
腹腔鏡下手術トレーニングボックスを用いた鏡視下手術手技理解促進のための基礎的検討,
第26回日本内視鏡外科学会総会, 2013年11月. 徳永卓哉, 川上行奎, 栗田信浩, 安藤勤, 余喜多史郎 :
地域医療における遠隔医療配信システムの構築―手術動画配信システム導入による効率的な技術伝承―,
第26回日本内視鏡外科学会総会, 2013年11月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 徳永卓哉, 松本規子, 赤池雅史 :
開腹手術は内視鏡下手術トレーニングに必要である∼鏡視下手術理解促進のための基礎的検討∼,
第75回日本臨床外科学会総会, 2013年11月. 西正暁, 島田光生, 佐藤宏彦, 栗田信浩, 岩田貴, 吉川幸造, 東島潤, 近清素也, 徳永卓哉, 髙須千絵, 柏原秀也, 松本規子, 江藤祥平 :
進行下部直腸癌に対するS-1，UFT併用術前化学放射線療法の予後,
第51回日本癌治療学会学術集会, 2013年10月. 西正暁, 島田光生, 栗田信浩, 岩田貴, 佐藤宏彦, 吉川幸造, 東島潤, 近清素也, 徳永卓哉, 柏原秀也, 松本規子, 江藤祥平 :
進行胃癌に対する治療方針決定におけるthrombospondin1(THBS1)発現の意義,
第24回日本消化器癌発生学会総会, 2013年9月. 徳永卓哉, 島田光生, 森大樹, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 花岡潤, 杉本光司, 齋藤裕, 淺野間理仁, 山田眞一郎, 三宅秀則 :
Bevacizumab(Bev)が小胞体ストレス応答を介して肝切除後肝機能障害を改善する,
第112回日本外科学会定期学術集会, 2012年4月.

(キーワード): 国内学会

研究会・報告書: 柏原秀也, 島田光生, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 髙須千絵, 江藤祥平, 良元俊昭 :
経肛門的内視鏡下直腸間膜切除術TaTME併用ロボット支援下直腸切除術の有用性,
日本消化器病学会四国支部第114回例会, 2020年12月. 徳永卓哉, 島田光生, 齋藤裕, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭, 杉本真樹 :
Trans-perineal APRにおける術前VR・MRシミュレーション,
第29回日本コンピュータ外科学会大会, 2020年11月. 良元俊昭, 吉川幸造, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 島田光生 :
血液透析患者に対する胃癌手術症例の検討,
第58回日本癌治療学会学術集会, 2020年10月. 吉川幸造, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 江藤祥平, 良元俊昭 :
ロボット支援下胃切除術における左側LCSの有用性,
第58回日本癌治療学会学術集会, 2020年10月. 吉川幸造, 島田光生, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子 :
進行胃癌に対するロボット支援下胃切除術の有用性-地方からの提言-,
第74回手術手技研究会, 2020年10月. 高橋叡, 西正暁, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子, 池本哲也 :
MRIが郭清範囲決定の一助となった早期胃癌の1例,
第120回日本外科学会定期学術集会, 2020年8月. 武原悠花子, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭, 島田光生 :
大腸癌におけるFrailの意義とメカニズムの検討,
第120回日本外科学会定期学術集会, 2020年8月. 良元俊昭, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 武原悠花子, 島田光生 :
血液透析患者に対する胃癌手術症例の検討,
第120回日本外科学会定期学術集会, 2020年8月. 徳永卓哉, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 齋藤裕, 柏原秀也, 髙須千絵, 良元俊昭, 武原悠花子, 杉本真樹 :
直腸切断術TpTMEにおける術前VR・MRシミュレーションと術中尿道造影ナビゲーションの有用性,
第120回日本外科学会定期学術集会, 2020年8月. 柏原秀也, 島田光生, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 髙須千絵, 良元俊昭 :
腹腔鏡下胃・大腸癌手術における術前減量プログラムは短期成績改善に寄与する,
第120回日本外科学会定期学術集会, 2020年8月. 西正暁, 島田光生, 徳永卓哉, 吉川幸造, 宮谷知彦, 髙須千絵, 柏原秀也, 良元俊昭, 武原悠花子 :
下部直腸癌CRT後リンパ球CRP比(LCR)は予後不良因子になる,
第120回日本外科学会定期学術集会, 2020年8月. 吉川幸造, 島田光生, 宮谷知彦, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 良元俊昭 :
胃癌術前T1N0症例における正診率向上の取り組み-的確なリンパ節郭清を目指して-,
第120回日本外科学会定期学術集会, 2020年8月. 髙須千絵, 島田光生, 吉川幸造, 宮谷知彦, 西正暁, 徳永卓哉, 柏原秀也, 武原悠花子 :
地方外科から発信するダイバーシティ・インクルージョンを目指した取り組み,
第120回日本外科学会定期学術集会, 2020年8月. 良元俊昭, 武原悠花子, 柏原秀也, 髙須千絵, 西正暁, 徳永卓哉, 宮谷知彦, 吉川幸造, 森根裕二, 島田光生 :
LED 光による新たな癌制御法の開発,
第261 回徳島医学会学術集会(令和 2 年度夏期), 2020年8月. 髙須千絵, 柏原秀也, 吉川幸造, 宮谷知彦, 徳永卓哉, 西正暁, 良元俊昭, 武原悠花子 :
経肛門的内視鏡下直腸間膜切除術 TaTME併用ロボット支援下直腸切除術の有用性,
第113回日本消化器病学会四国支部例会, 2020年6月.

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 青色光の大腸癌と腫瘍微小環境への抗腫瘍効果およびabscopal効果に関する研究 (研究課題/領域番号: 24K11805 )
Gut-brain axisからみたMetabolic surgeryの血糖抑制効果 (研究課題/領域番号: 24K11741 )
免疫チェックポイント阻害薬治療時おけるhyperprogressinのメカニズムの解明 (研究課題/領域番号: 23K08091 )
AIを用いた対話型医療面接トレーニングシステムの開発 (研究課題/領域番号: 22K10363 )
脂肪幹細胞由来Schwann様細胞の骨盤内臓神経再生促進効果に関する研究 (研究課題/領域番号: 22K08713 )
肥満手術後腸内細菌叢を用いた新たな肥満治療開発に関する研究 (研究課題/領域番号: 21K08595 )
術後排尿障害モデルにおける脂肪由来幹細胞制御による神経再生促進効果に関する研究 (研究課題/領域番号: 19K09072 )
骨髄由来免疫抑制細胞を標的とした放射線治療抵抗性の制御メカニズムの解明 (研究課題/領域番号: 19K09071 )
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2024年11月9日更新

研究者番号: 30448328

所属（現在）: 2024/4/1 : 徳島大学, 病院, 特任教授

所属（過去の研究課題 情報に基づく）*注記: 2024/4/1 : 徳島大学, 病院, 特任教授
2022/4/1 – 2023/4/1 : 徳島大学, 病院, 助教
2021/4/1 : 徳島大学, 病院, 特任准教授
2019/4/1 – 2020/4/1 : 徳島大学, 病院, 助教

審査区分/研究分野

研究代表者

小区分55010:外科学一般および小児外科学関連

研究代表者以外

小区分55010:外科学一般および小児外科学関連
小区分58010:医療管理学および医療系社会学関連

キーワード

研究代表者

神経再生 / 術後排尿障害 / ADSC / HMGB1 / 脂肪由来幹細胞 / Schwann細胞 / 排尿障害 / mTORC1 / HGGB1 / 修復Schwann細胞 / Schwann様細胞 / Exosome / 脂肪由来間葉系幹細胞（ADSC） / exosome

研究代表者以外

直腸癌 / 放射線治療抵抗性 / 骨髄由来免疫制御細胞 / miR-223 / CRT / SDF-1 / バイオマーカー / 大腸癌 / 放射線治療 / 青色LED / 光治療 / オートファジー / 腫瘍免疫 / 腫瘍微小環境 / 腫瘍関連マクロファージ / Bariatric surgeery / gut microbiota / インスリン抵抗性 / NASH / 炎症性サイトカイン / 腸管透過性 / 肝発癌 / metabolic surgery / 腸内細菌叢 / 便移植 / 免疫チェックポイント阻害薬治療 / Hyperprogression / 制御性T細胞 / PD1発現 / エクソソーム / 言語理解 / 知能情報 / 医療面接 / AI / トレーニング / 自学自習 / 音声認識 / 医療面接トレーニング / Metabolic surgery / 血糖上昇抑制効果 / Gut-brain axis / 肥満症 / 小腸 glucose transporter

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徳永 卓哉

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