トップ研究者を探す動脈硬化の進展と破綻における新規の慢性炎症惹起機構の解明と治療法の開発

動脈硬化の進展と破綻における新規の慢性炎症惹起機構の解明と治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19H03654
研究種目 基盤研究(B)
研究分野
研究機関 徳島大学
代表研究者 佐田 政隆
研究分担者 福田 大受
研究分担者 添木 武
研究分担者 堀川 一樹
研究期間 開始年月日 2019/4/1
研究期間 終了年度 2021
研究ステータス 完了 (2021/4/1)
配分額(合計) 17,550,000 (直接経費 :13,500,000、間接経費 :4,050,000)
配分額(履歴) 2021年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2020年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2019年度:9,230,000 (直接経費 :7,100,000、間接経費 :2,130,000)
キーワード 動脈硬化
慢性炎症
自然免疫
脂質異常症
自己核酸
アポトーシス
STING
Toll様受容体
インスリン抵抗性
骨髄
血管
マクロファージ
生活習慣病
肥満

研究成果

[雑誌論文] Clinical clerkship students’ preferences and satisfaction regarding online lectures during the COVID-19 pandemic

Yagi Shusuke、Fukuda Daiju、Ise Takayuki、Yamaguchi Koji、Kusunose Kenya、Kadota Muneyuki、Kawabata Yutaka、Matsuura Tomomi、Soga Tomohiro、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Kawahito Shinji、Sata Masataka 2022

[雑誌論文] Effects of Radiofrequency Catheter Ablation on Cardiac Reserve Using Preload Stress Echocardiography in Paroxysmal and Persistent Atrial Fibrillation

Ishii Nao、Kusunose Kenya、Shono Ayu、Matsumoto Kensuke、Nishio Susumu、Yamaguchi Natsumi、Hirata Yukina、Matsuura Tomomi、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2022

[雑誌論文] Impact of Tweeting Summaries by the Japanese Circulation Society Official Account on Article Viewership ― Pilot Trial ―

Mizuno Atsushi、Kusunose Kenya、Kishi Takuya、Rewley Jeffrey、Matsumoto Chisa、Sahashi Yuki、Ishida Mari、Sanada Shoji、Fukuda Memori、Sugimoto Tadafumi、Hirano Miki、Yoneoka Daisuke、Sata Masataka、Anzai Toshihisa、Node Koichi 2022

[学会発表] First Assessment of Coronary Plaque Vulnerability and Lipid Core Burden Assessed by Near-Infrared Spectroscopy-Intravascular Ultrasound in a Fresh Cadaver

川端 豊、若槻 哲三、山口 浩司、福田 大受、西條 良仁、門田 宗之、松浦 朋美、伊勢 孝之、楠瀬 賢也、八木 秀介、山田 博胤、添木 武、佐田 政隆 2022

[雑誌論文] Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases

Fukuda Daiju、Pham Phuong Tran、Sata Masataka 2022

[学会発表] The Innate Immune System: A Possible Link between Lifestyle-related Diseases and Atherosclerosis

Fukuda D, Sata M 2022

[雑誌論文] Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction

Higashikuni Yasutomi、Liu Wenhao、Sata Masataka 2022

[雑誌論文] Left Atrial Strain Associated with Functional Recovery in Patients Receiving Optimal Treatment for Heart Failure

Torii Yuta、Kusunose Kenya、Hirata Yukina、Nishio Susumu、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2021

[雑誌論文] Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora

Tsutsumi Rie、Yamasaki Yuki、Takeo Jiro、Miyahara Hiroko、Sebe Mayu、Bando Masahiro、Tanba Yousuke、Mishima Yuna、Takeji Kana、Ueshima Nanako、Kuroda Masashi、Masumoto Saeko、Harada Nagakatsu、Fukuda Daiju、Yoshimoto Ryoko、Tsutsumi Yasuo M、Aihara Ken-ichi、Sata Masataka、Sakaue Hiroshi 2021

[雑誌論文] An Adult Case of Congenital Extrahepatic Portosystemic Shunt Successfully Treated with Balloon-occluded Retrograde Transvenous Obliteration

Tanaka Hironori、Saijo Yoshihito、Tomonari Tetsu、Tanaka Takahiro、Taniguchi Tatsuya、Yagi Shusuke、Okamoto Koichi、Miyamoto Hiroshi、Sogabe Masahiro、Sato Yasushi、Muguruma Naoki、Tsuneyama Koichi、Sata Masataka、Takayama Tetsuji 2021

[学会発表] マクロファージのDNA分解機構が動脈硬化に与える影響

數籐 久美子、福田 大受、佐田 政隆 2021

[雑誌論文] Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant <i>Staphylococcus aureus</i>

Yagi Shusuke、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Matsuura Tomomi、Yamaguchi Koji、Soeki Takeshi、Wakatsuki Tetsuzo、Hata Hiroki、Sata Masataka 2021

[雑誌論文] Quantification of Carotid Plaque Histology Using iPlaque Software

Ogata Toshiyasu、Shimada Hirofumi、Inoue Tooru、Takeshita Sho、Tsuboi Yoshio、Uesugi Noriko、Fujiwara Mika、Sata Masataka、Yamada Hirotsugu 2021

[雑誌論文] Evaluation of the input site and characteristics of the antegrade fast pathway based on three-dimensional bi-atrial stimulus-ventricle mapping

Matsumoto Kazuhisa、Tobiume Takeshi、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Yamaguchi Koji、Yagi Shusuke、Fukuda Daijyu、Wakatsuki Tetsuzo、Yamada Hirotsugu、Soeki Takeshi、Sata Masataka 2021

[学会発表] Roles of Epicardial Adipose Tissue in the Progression of Coronary Atherosclerosis

Sata M 2021

[雑誌論文] How to standardize the measurement of left ventricular ejection fraction

Kusunose Kenya、Zheng Robert、Yamada Hirotsugu、Sata Masataka 2021

[雑誌論文] Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

Ganbaatar Byambasuren、Fukuda Daiju、Shinohara Masakazu、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Hirata Ken-ichi、Sata Masataka 2021

[雑誌論文] Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease

Takashima Akira、Yagi Shusuke、Yamaguchi Koji、Kurahashi Kiyoe、Kojima Yuko、Zheng Robert、Ise Takayuki、Kusunose Kenya、Yoshida Sumiko、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Aihara Ken-ichi、Akaike Masashi、Sata Masataka 2021

[雑誌論文] Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction

Maimaituxun Gulinu、Kusunose Kenya、Yamada Hirotsugu、Fukuda Daiju、Yagi Shusuke、Torii Yuta、Yamada Nao、Soeki Takeshi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio 2021

[雑誌論文] Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice

Suto Kumiko、Fukuda Daiju、Shinohara Masakazu、Ganbaatar Byambasuren、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Hirata Ken-ichi、Sata Masataka 2021

[雑誌論文] Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

Higashikuni Yasutomi、Liu Wenhao、Obana Takumi、Sata Masataka 2021

[雑誌論文] Impact of cancer on short-term in-hospital mortality after primary acute myocardial infarction

Zheng Robert、Kusunose Kenya、Okushi Yuichiro、Okayama Yoshihiro、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2021

[雑誌論文] Selexipag for Chronic Thromboembolic Pulmonary Hypertension in Japanese Patients ― A Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase II Study ―

Tanabe Nobuhiro、Fukuda Keiichi、Matsubara Hiromi、Nakanishi Norifumi、Tahara Nobuhiro、Ikeda Satoshi、Kishi Takuya、Satoh Toru、Hirata Ken-ichi、Inoue Teruo、Kimura Hiroshi、Okano Yoshiaki、Okazaki Osamu、Sata Masataka、Tsujino Ichizo、Ueno Shuichi、Yamada Norikazu、Yao Atsushi、Kuriyama Takayuki 2020

[雑誌論文] Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Tomiyama Hirofumi、Vlachopoulos Charalambos、Xaplanteris Panagiotis、Sata Masataka、Ishibashi Yutaka、Node Koichi、Tanaka Atsushi、Maemura Koji、Ohya Yusuke、Furukawa Taiji、Ito Hiroshi、Ohkuma Toshiaki、Ninomiya Toshiharu、Chikamori Taishiro、Yamashina Akira、Ueda Shin-ichiro 2020

[雑誌論文] Relationship between regional left ventricular dysfunction and cancer-therapy-related cardiac dysfunction

Saijo Yoshihito、Kusunose Kenya、Okushi Yuichiro、Yamada Hirotsugu、Toba Hiroaki、Sata Masataka 2020

[学会発表] Pulmonary Artery Hypertension Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary Hypertension

Kenya Kusunose, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata 2020

[雑誌論文] Classification of physical activity in patients with heart failure categorized as New York Heart Association class I or II

Doi Sayuri、Tamura Ayako、Minagawa Takako、Osaka Akemi、Sata Masataka 2020

[雑誌論文] Identifying the extent of oral fluid droplets on echocardiographic machine consoles in COVID-19 era

Kusunose Kenya、Matsunaga Kosuke、Yamada Hirotsugu、Sata Masataka 2020

[学会発表] Differences ofCancer Types in Hospital Mortality in Patients With Venous Thromboembolism

Okushi Y, Kusunose K, Ise T, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Sata M: 2020

[学会発表] Clinical Utility of Noninvasive Assessment of Flow-pressure Relationship in Scleroderma

Arase M, Kusunose K, Morita S, Yamaguchi N, Hirata Y, Nishio S, Ise T, Yamaguchi K, Fukuda D, Yagi S, Yamada H, Soeki T, Wakatsuki T, Sata M 2020

[学会発表] Deep learning for screening of pulmonary hypertension using standard chest X-Ray

Hirata Y, Kusunose K, Ymaguchi N, Morita S, Nishio S, Okushi Y, Takahashi T, Yamada H, Tsuji T, Fujimori K, Kotoku J, Sata M 2020

[学会発表] Deep Learning For Detection Of Elevated Pulmonary Artery Wedge Pressure Using Standard Chest X-ray

Hirata Y, Kusunose K, Yamada H, Tsuji T, Fujimori K, Kotoku J, Sata M 2020

[学会発表] Suppressed Local Coagulative Response After Newer-generation Ultrathin Strut SES Implantation Compared to Older-generation SES Implantation

Yamaguchi K, Wakatsuki T, Takahashi T, Kadota M, Kawabata Y, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M 2020

[雑誌論文] Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Prediabetes ― A Consensus Statement Jointly From the Japanese Circulation Society and the Japan Diabetes Society ―

Araki Eiichi、Tanaka Atsushi、Inagaki Nobuya、Ito Hiroshi、Ueki Kohjiro、Murohara Toyoaki、Imai Kenjiro、Sata Masataka、Sugiyama Takehiro、Ishii Hideki、Yamane Shunsuke、Kadowaki Takashi、Komuro Issei、Node Koichi、on behalf of the Directors of the JCS and JDS 2020

[雑誌論文] Deep learning to predict elevated pulmonary artery pressure in patients with suspected pulmonary hypertension using standard chest X ray

Kusunose Kenya、Hirata Yukina、Tsuji Takumasa、Kotoku Jun’ichi、Sata Masataka 2020

[学会発表] Genetic Deletion of Stimulator of Interferon Genes Attenuates Atherogenesis in Apolipoprotein E-deficient Mice

Phuong Tran Pham, Fukuda D, Sata M 2020

[雑誌論文] Effects of canagliflozin in patients with type 2 diabetes and chronic heart failure: a randomized trial (CANDLE)

Tanaka Atsushi、Hisauchi Itaru、Taguchi Isao、Sezai Akira、Toyoda Shigeru、Tomiyama Hirofumi、Sata Masataka、Ueda Shinichiro、Oyama Jun‐ichi、Kitakaze Masafumi、Murohara Toyoaki、Node Koichi、CANDLE Trial Investigators 2020

[雑誌論文] Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice

Ganbaatar Byambasuren、Fukuda Daiju、Shinohara Masakazu、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Hirata Ken-ichi、Sata Masataka 2020

[雑誌論文] Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice

Aini Kunduziayi、Fukuda Daiju、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Sata Masataka 2019

[学会発表] Adipose tissue surrounding the kidney and its impact on coronary artery disease

Maimaituxun G, Fukuda D, Yagi S, Takao S, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M, Shimabukuro M 2019

[学会発表] Vildagliptin reduces inducitiligy of arterial fibrillation in hypertensive rats complicated with diabetes mellitus,

Soeki T, Matsumoto K, Fukuda D, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yamada H, Wakatsuki T, Sata M 2019

[学会発表] Impact of epicardial adipose tissue on global longitudinal strain: a study in patients with normal left ventricular ejection fraction

Maimaituxun G, Kusunose K, Fukuda D, Yagi S, Torii Y, Hirata Y, Nishio S, Yamada N, Yamada H, Soeki T, Wakatsuki T, Sata M, Shimabukuro M 2019

[雑誌論文] A case of subacute thyroiditis associated with complete occlusion of right coronary artery

Bando Hiroshi、Nakanishi Akinori、Syunto Jouji、Synto Reiko、Sata Masataka 2019

[雑誌論文] Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Kajikawa Masato、Kihara Yasuki、Yusoff Farina Mohamad、Kishimoto Shinji、Chayama Kazuaki、Goto Chikara、Noma Kensuke、Nakashima Ayumu、Hiro Takafumi、Hirayama Atsushi、Shiina Kazuki、Tomiyama Hirofumi、Yagi Shusuke、Amano Rie、Yamada Hirotsugu、Sata Masataka、Higashi Yukihito 2019

[学会発表] S1p2 Receptor Antagonist Attenuates Endothelial Dysfunction And Inhibits Atherogenesis In Apolipoprotein-e-deficient Mice

Ganbaatar B, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M 2019

[雑誌論文] Long-surviving Anomalous Origin of the Right Pulmonary Artery from the Ascending Aorta Complicated with Pulmonary Arteriovenous Fistula

Ueno Rie、Yagi Shusuke、Bando Masaaki、Sata Masataka 2019

[雑誌論文] Recurrent venous thrombosis during direct oral anticoagulant therapy in a patient with protein S deficiency

Yagi Shusuke、Kagawa Kumiko、Fujimoto Eiki、Sata Masataka 2019

[雑誌論文] Updated Left Ventricular Diastolic Function Recommendations and Cardiovascular Events in Patients with Heart Failure Hospitalization

Torii Yuta、Kusunose Kenya、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Amano Rie、Yamao Masami、Zheng Robert、Saijo Yoshihito、Yamada Nao、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2019

[学会発表] Assessment of left ventricular ejection fraction from echocardiographic images using deep learning algorithm

Kusunose K, Haga A, Abe T, Fukuda D, Yamada H, Sata M 2019

[学会発表] Increased advanced glycation end products are a risk factor of epicardial adipose tissue thickness

Yagi S, Sata M 2019

[学会発表] Empagliflozin, a SGLT2 inhibitor, attenuates endothelial dysfuntion and atherogenesis by inhibiting inflammatory responses in the vasculature and adipose tissue in diabetic apolipoprotein E-deficient

Ganbaatar B, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M 2019

[学会発表] Pemafibrate, a novel selective peroxisome proliferator-activated receptor-a modulator, ameliorated diabetes-induced endothelial dysfunction

Sutou K, Fukuda D, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M 2019

[学会発表] The relationship among local epicardial adipose tissue, coronary intraplaque microluminal structure, and coronary plaque formation -a fresh cadaveric study

Kawabata Y, Kusunose K, Yagi S, Yamada H, Fukuda D, Soeki T, Sata M 2019

[学会発表] Glycemic control with canagliflozin, a SGLT-2 inhibitor, attenuates atherosclerosis and endothelial dysfuntion in diabetic apolipoprotein e-deficient mice

Rahadian A, Fukuda D, Salim H, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M 2019

[雑誌論文] Mass on the head : Spontaneous arteriovenous fistula of the superficial temporal artery

Yagi Shusuke、Saijo Yoshihito、Matsuda Taku、Kanematsu Yasuhisa、Sata Masataka 2019

[雑誌論文] Rupture of pes anserine bursa in a patient with pes anserine pain syndrome due to osteoarthritis

Yagi Shusuke、Sata Masataka 2019

[雑誌論文] Measurement of hemodynamics immediately after vaginal delivery in healthy pregnant women by electrical cardiometry

Yoshida Atsuko、Kaji Takashi、Yamada Hirotsugu、Yonetani Naoto、Sogawa Eishi、Yamao Masami、Maeda Kazuhisa、Sata Masataka、Irahara Minoru 2019

[学会発表] Usefulness of echocardiographic epicardial adipose tissue thickness for predicting coronary artery disease regardless of body mass index

Hirata Y, Sata M, Kusunose K, Yamada H, Torii Y, Nishio S, Yamada N, Yamaguchi K, Soeki T, Wakatsuki T 2019

[学会発表] Clinical utility of left atrial strain to predict functional recovery in patients with optimal treatments of heart failure

Torii Y, Kusunose K, Hirata Y, Yamada H, Sata M 2019

[学会発表] The improvement of chronic local coagulative response according to the progress of drug eluting stent

Yamaguchi K, Wakatsuki T, Ueno R, Kawabata Y, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M 2019

[学会発表] Effects of canagliflozin in patients with type 2 diabetes and chronic heart failure: A randomized clinical trial (CANDLE)

Tanaka A, Sata M, Ueda S, Murohara T, Node K: 2019

[学会発表] Vildagliptin, a DPP-4 inhibitor, attenuates endothelial dysfunction and atherogenesis independent of its glucose lowering effect in apolipoprotein e-deficient mice

Aini K, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M 2019