トップ研究者を探す腫瘍特異的T細胞レセプター遺伝子導入による革新的造血幹細胞移植療法

腫瘍特異的T細胞レセプター遺伝子導入による革新的造血幹細胞移植療法

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19390265
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 愛媛大学
代表研究者 安川 正貴
研究分担者 薬師神 芳洋
連携研究者 薬師神 芳洋
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 18,460,000 (直接経費 :14,200,000、間接経費 :4,260,000)
配分額(履歴) 2008年度:7,930,000 (直接経費 :6,100,000、間接経費 :1,830,000)
2007年度:10,530,000 (直接経費 :8,100,000、間接経費 :2,430,000)
キーワード がん免疫療法
細胞傷害性T細胞
T細胞レセプター遺伝子
遺伝子治療
造血幹細胞移植
T細胞レセプター
造血幹細胞
がん免疫
白血病

研究成果

[雑誌論文] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia

Ochi, T., Yasukawa, M. Yakushijin, Y., et.al. 2009

[雑誌論文] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation

Matsubara E, Yasukawa M, Yakushijin, Y.,et.al. 2009

[雑誌論文] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et al. 2009

[雑誌論文] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia

Ochi, T., Yasukawa, M., et al. 2009

[雑誌論文] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrjome

Yasukawa, M., et al. 2009

[雑誌論文] Clinical significance of co-expression of CD21 and LFA-1 in non-Hodgkin' s B-celllymphoma

Tanimoto, K., Yasukawa, M., et al. 2009

[雑誌論文] Therapeutic effect of accmulaticn of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model

Hasegawa, H., Yasukawa, M., et al. 2009

[雑誌論文] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et al. 2009

[雑誌論文] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation

Matsubara, E., Yasukawa, M., et al. 2009

[雑誌論文] Identification of an epitope derived from CML66, a novel tumor-associated antigen broadly expressed in human leukemia, recognized by HLA-A*2402-restricted cytotoxic T lymphocytes

Suemori, K., Yasukawa, M. Yakushijin, Y., et.al. 2008

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation

Hato, T., Yakushijin, Y., Yasukawa, M., et.al. 2008

[学会発表] 腫瘍関連抗原CML66の臨床的有用性

末盛浩一郎、安川正貴、他 2008

[学会発表] 腫瘍関連抗原CML66の臨床的有用性

末盛浩一郎, 安川正貴, 他 2008

[雑誌論文] Allogeneic stem cell transplantation for refractory adult T-cell leukemia using a non-T-cell-depleted HLAincompatible family donor graft, with reference to the grown-up child donor to parent recipient setting : report of a pilot study

Fujiwara, H., Yasukawa, M., et.al. 2008

[雑誌論文] Identification of an epitope derived from CML66, a novel tumor associated antigen broadly expressed in human leukemia, recognized by HLA-A^*2402-restricted cytotoxic T lymphocytes

Suemori K, Yasukawa M, et. al. 2008

[学会発表] Aurora-A kinase : A novel target of cellular immunotherapy for humanleukemia

Ochi, T., Yasukawa, M., et al 2008

[学会発表] Establishment and characterization of a novel CD8+ T cell line with cytotoxicity via perforin / granzyme B

Suemori, K., Yasukawa, M. etal. 2008

[学会発表] Clinical significance of CD21 Co-Expression with LFA-1 in Non-Hodgkin's B-cell lymphoma

Tanimoto, K., Yasukawa, M., et.al. 2008

[学会発表] Establishment and characterization of a novel CD8+T cell line with cytotoxicity via perforin / granzyme B.

Suemori, K., Yasukawa, M., et.al. 2008

[雑誌論文] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model

Hasegawa, H., Yasukawa, M. et.al. 2008

[学会発表] Aurora-A kinase : A novel target of cellular immunotherapy for human leukemia

Ochi, T., Yasukawa, M. et.al. 2008

[学会発表] Aurora-A kinaseを標的とした抗白血病免疫療法の開発

越智俊元, 安川正貴, 他 2008

[学会発表] Aurora-A kinaseを標的とした抗白血病免疫療法の開発

越智俊元、安川正貴、他 2008

[雑誌論文] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model

Hasegawa H, Yasukawa M, et. al. 2008

[学会発表] Development of anti-leukemic immunotherapy targeting Aurora-A kinase

Ochi, T., Yasukawa, M., et.al. 2008

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation

Hato, T., Yasukawa, M., et al. 2008

[図書] Oncogene proteins : Targets for cancer immuno-cell therapy. Oncogene proteins : Structures, Functions and Analyses

Fujiwara, H., Yasukawa, M. 2008

[学会発表] Zinc finger protein 521/early hematopoietic zinc finger proteinの赤血球分化における役割

松原悦子、安川正貴、他 2008

[雑誌論文] Identification of an epitope derived from CML66, a novel tumor-associated antigenbroadly expressed in human leukemia, recognized by HLA-A*2402-restxicted cytotoxicT lymphocytes

Suemori, K., Yasukawa, M., et al. 2008

[学会発表] Integrin β3 membrane-proximal and-distal residues cooperatively regulate talin-mediated α〓bβ3 activation

Yamanouchi, J., Yasukawa, M., et.al. 2008

[学会発表] Zinc finger protein 521 の赤血球分化における制御機構の解析

松原悦子, 安川正貴, 他 2008

[雑誌論文] Allogeneic stem cell transplantation for refractory adult T-cell leukemia using anon-T-cell-depleted HLA-incompatible family donor graft, with reference to theg rcwn-up child donor to parent recipient setting : report of a pilot study

Fujiwara, H., Yasukawa, M., etal. 2008

[学会発表] Integrin β3 membrane-proximal and - distal residues cooperativelyregulate talin-mediated α II bβ3 activation

Yamanouchi, J., Yasukawa, M., et al. 2008

[学会発表] Zinc finger protein 521 / early hematopoietic zinc finger proteinの赤血球分化における役割

松原悦子, 安川正貴, 他 2008

[図書] Oncogene proteins : Structures, Functions and Analyses

Fujiwara, H., Yasukawa, M. 2008

[学会発表] Zinc finger protein 521の赤血球分化における制御機構の解析

松原悦子、安川正貴、他 2008

[学会発表] Clinical significance of CD21 Co-Expression with LFA-1 in Non-Hodgkin's B-cell limphoma

Tanimoto, K., Yasukawa, M., et al. 2008

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3cytoplasmic domain in regulation of talin-・mediated alpha IIbbeta 3 activation

Hato T, Yasukawa M, et. al. 2008

[雑誌論文] Absence of chlamydial infection in Japanese patients with ocular adnexal MALT lymphoma

Yakushijin, Y., Yasukawa. M. et.al. 2007

[学会発表] Cytotoxic T-lymphocytes harnessing CML66 can kill human myeloid leukemia cells in vitro

Suemori K, Yasukawa M, et. al. 2007

[学会発表] Aurora-A kinase: A novel target for the immunotherapy against human leukemias

Ochi T, Yasukawa M, et. al. 2007

[図書] 造血器腫瘍「細胞免疫療法各論」

安川 正貴 2007

[雑誌論文] Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis

Nagafuji, K., Yasukawa, M., et.al. 2007

[雑誌論文] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone

Ikeda, K., Yasukawa, M., et.al. 2007

[図書] 造血器腫瘍「細胞免疫療法総論」

安川 正貴 2007

[学会発表] 腫瘍関連抗原CML66特異的細胞傷害性T細胞の誘導と機能解析

末盛 浩一郎、安川 正貴、 他 2007

[学会発表] Identification of an epitope derived from Aurora-A kinase which induces leukemia-specific CTL

Ochi T, Yasukawa M, et. al. 2007

[雑誌論文] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice

Hasegawa H, Yasukawa M, et. al. 2007

[雑誌論文] Wilms tumor gene WT1 pepide-based immunotherapy induced a minimal response in a patient with advanoed therapy-resistant multiple myeloma

Tsuboi A, Yasukawa M, et. al. 2007

[学会発表] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal dameges in a murine acute GVHD model

Yamanouchi J, Yasukawa M, et. al. 2007

[雑誌論文] Identification and characterization of a WT1(Wilms'tumor gene)protein-derived HLA-DRB1^*0405-restricted 16-mer helper peptide that proxnotes the induction and activation of WT1-specific cytotoxic T lymphocytes

Fujiki F, Yasukawa M, et. al. 2007

[雑誌論文] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice

Hasegawa, H., Yasukawa, M., et.al. 2007

[雑誌論文] The role of Wilms'tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal hemoglobinuria clone

Ikeda K, Yasukawa M, et. al. 2007

[雑誌論文] Nationwide survey of hemophagocytic lymphohistiocytosis in Japan

Ishii, E., Yasukawa, M., et.al. 2007

[学会発表] Induction and functional analysis of CML66-specific cytotoxic T lymphocytes

Suemori K, Yasukawa M, et. al. 2007

[雑誌論文] A mitotic kinase TOPK enhances cdk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis

Abe, Y., Yasukawa, M. et.al. 2007

[雑誌論文] Identification and characterization of a WT1 (Wilms' tumor gene) proteinderived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes

Fujiki, F., Yasukawa, M., et.al. 2007

[学会発表] ヒト細胞傷害性T細胞が認識するAurora-A由来エピトープの同定

越智 俊元、安川 正貴, 他 2007

[雑誌論文] Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma

Tsuboi, A., Yasukawa, M., et.al. 2007

[雑誌論文] Association of human herpesvirus-6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome

Tohyama, M., Yasukawa, M., et.al. 2007

[雑誌論文] A mitotic kinase TOPK enhanoes odk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis

Abe Y, Yasukawa M, et. al. 2007

[雑誌論文] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrome

Yasukawa, M., Yakushijin, Y., et.al.

[雑誌論文] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., Yakushijin, Y., et.al.

[雑誌論文] Clinical significance of co-expression of CD21 and LFA-1 in non-Hodgkin's B-cell lymphoma

Tanimoto, K., Yakushijin, Y., Yasukawa, M., et.al.

[雑誌論文] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

Suemori, K., Yasukawa, M., et.al.