トップ研究者を探す非CpGアイランド領域シトシンメチル化の包括的病態解析

非CpGアイランド領域シトシンメチル化の包括的病態解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19390100
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
基礎医学
人体病理学
研究機関 神戸大学
代表研究者 北澤 荘平
研究分担者 武中 篤
研究分担者 梶 博史
研究分担者 北澤 理子
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額(合計) 10,140,000 (直接経費 :7,800,000、間接経費 :2,340,000)
配分額(履歴) 2010年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2009年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2008年度:2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
2007年度:4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
キーワード 非CpCアイランド
メチル化
遺伝子プロモータ
非CpGアイランド
遺伝プロモータ
膀胱癌
造血細胞
転写因子
エピジェネティクス
CpG-island
DNAメチル化
BANBI
転写制御
副甲状腺過形成
P16
BAMBI

研究成果

[図書] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level. In Microscopy : Science, Technology, Applications and Education

S.Kitazawa, et al 2011

[学会発表] ラット酸化的ストレスモデルにおける腎腫瘍発生初期に生じるエピジェネティクス変化の解析

北澤荘平, 他 2010

[雑誌論文] Enhancement of ultraviolet B-induced skin tumor development in phospholipase C knockout mice is associated with decreased apoptosis.

Oka M, Edamatsu H, Kunisada M, Dien S, Kitazawa R, Kataoka T, Nishigori C. 2010

[図書] 組織細胞化学2010-組織細胞化学イメージングの基礎と最前線:生体内分子局在と機能を探る-日本組織細胞化学会編集 エピジェネティクスと病理組織学的変

北澤荘平, 森清, 近藤武史, 北澤理子 2010

[学会発表] Derepression of mouse SFRP-4 gene expression by oxidative stress : A plausible mechanism leading to low-turnover osteoporosis in diabetes and senscence.

Kiyoshi Mori, Riko Kitazawa, Takeshi Kondo, Satomi Mukai, Michiko Mori, Sohei Kitazawa 2010

[学会発表] Identification and functional analysis of a novel splicing variant of mouse RANK.

Satomi Mukai, Riko Kitazawa, Junko Ishii, Takeshi Kondo, Akihiro Hakozaki, Keisuke Horiuchi, Kiyoshi Mori, Sohei Kitazawa 2010

[雑誌論文] Depressed expression of Klotho and FGFR1 in hyperplastic parathyroid glands from uremic patients.

Komaba H, Goto S, Fujii H, Hamada Y, Kobayashi A, Shibuya K, Tominaga Y, Otsuki N, Nibu K, Kitazawa R, Fukagawa M. 2010

[学会発表] RANKL upregulates mouse RANK gene transcriptionthrough the NFAT binding site of RANK gene promoter.

Riko Kitazawa, Junko Ishii, Satomi Mukai, Takeshi Kondo, Michiko Mori, Kiyoshi Mori, Sohei Kitazawa 2010

[雑誌論文] Oxidative and nitrosative stress and progression of diabetic nephropathy in type 2 diabetes.

Fujii H, Kono K, Nakai K, Goto S, Komaba H, Hamada Y, Shinohara M, Kitazawa R, Kitazawa S, Fukagawa M. 2010

[学会発表] マウスRANK遺伝子転写におけるNFATの機能解析

北澤理子, 他 2009

[雑誌論文] BAMBI gene is epigenetically silenced in a subset of high-grade bladder cancer

Sann Sanda Khin, Kitazawa R, Win N, Than TA, Mori K, Kondo T, Kitazawa S 2009

[雑誌論文] Lipopolysaccharide Suppresses RANK Gene Expression in Macrophages by Down-Regulating PU.1 and MITF

Ishii J, Kitazawa R, Mori K, McHugh K. P., Morii E, Kondo T, Kitazawa S 2008

[雑誌論文] Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D3

Kitazawa R, Mori K, Yamaguchi A, Kondo T, Kitazawa S 2008

[雑誌論文] MeCP2 Expression and Promoter Methylation of Cyclin D1 Gene are Associated with Cyclin D1 Expression in Developing Rat Epididymal Duct

Darwanto A, Kitazawa R, Kondo T, Kitazawa S 2008

[雑誌論文] Lipopolysaccharide Suppresses RANK Gene Expression in Macrophages by Down-Regulating PU. 1 and MITF

Ishii J, Kitazawa R, Mori K, McHugh K. P., Morii E, Kondo T, Kitazawa S 2008

[雑誌論文] Hypermethylation of Epithelial-cadherin Gene Promoter is Associated with Epstein-Barr Virus in Nasopharyngeal Carcinoma

Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J 2008

[雑誌論文] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes

Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K 2008

[雑誌論文] Dexamethasone Promotes Osteoclastogenesis by Inhibiting Osteoprotegerin through Multiple Levels

Kondo T, Kitazawa R, Yamaguchi A, Kitazawa S 2008

[雑誌論文] FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets

Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, Okamura H, Fushiki T, Kasuga M 2008

[学会発表] BAMBI gene is epigenetically silenced in a subset of high-grade bladder cancer.

Sohei Kitazawa, Sann Sanda Khin, Kiyoshi Mori, Takeshi Kondo, Riko Kitazawa 2008

[雑誌論文] Hypermethylation of Epithelial-cadherin Gene Promoter is Associated with Epstein-Barr Virus in Nasopharyngeal, Carcinoma

Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J 2008

[雑誌論文] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway.

Kitazawa R., et al. 2008

[雑誌論文] MeCP2 Expression and Promoter Methylation of Cyclin D1 Gene Are Associated with Cyclin D1 Expression in Developing Rat Epididymal Duct

Darwanto A, Kitazawa R, Kondo T, Kitazawa S 2008

[学会発表] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 .

Riko Kitazawa, Kiyoshi Mori, Takeshi Kondo, Sohei Kitazawa 2007

[雑誌論文] Methylation Status of a Single CpG Locus 3 Bases Upstream of TATA-box of RANKL Gene Promoter Modulates Cell- and Tissue-specific RANKL Expression and Osteoclastogenesis

Kitazawa R, Kitazawa S 2007

[学会発表] Molecular cloning and characterization of mouse RANK gene promoter region

Junko Ishii, Riko Kitazawa, Takeshi Kondo, Mori K, Kevin P McHugh, Sohei Kitazawa 2007

[学会発表] STZ誘発糖尿病モデルラットにおける腎腫瘍発生初期におけるエピジェネティクス変化の解析

北澤荘平, 森清, 近藤武史, 北澤理子 2007

[学会発表] 日本とミャンマーにおける膀胱腫瘍進展過程におけるBAMBI遺伝子のエピジェネティクス制御の変化

サンサンダキン, 北澤理子, 近藤武史, 森清, タイタンエイ, ネウイン, 北澤荘平 2007

[図書] DNA Methylation Research Trends(Editor ; Kobayashi TB, Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research)

Kitazawa S, Mori K, kondo T, Fujimoto M, Kitazawa R 2007

[雑誌論文] Identification and analysis of function of a novel splicing variant of mouse receptor activator of NF-kappaB.

Mukai S, Kitazawa R, Ishii J, Kondo T, Hakozaki A, Hosiuchi K, Kiyoshi M, Kitazawa S.

[図書] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research(Editor; Kobayashi TB)

Kitazawa S, Mori K, Kondo T, Fujimoto M, Kitazawa R

[雑誌論文] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.

Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H

[雑誌論文] Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β (TGF-β) Signaling in Cancer (review)

Sann Sanda Khin, Kitazawa R, Kondo T, Idei Y, Fujimoto M, Haraguchi R, Mori K, Kitazawa S