トップ›研究者を探す›出生後早期に受けた各種ストレスが成長後の性機能に及ぼす長期的影響に関する研究

出生後早期に受けた各種ストレスが成長後の性機能に及ぼす長期的影響に関する研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18K09264
研究種目 基盤研究(C)
研究分野
研究機関 徳島大学
代表研究者 松崎 利也
研究分担者 苛原 稔
研究分担者 岩佐 武
研究期間 開始年月日 2018/4/1
研究期間 終了年度 2019
研究ステータス 中途終了 (2019/4/1)
配分額（合計） 4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
配分額（履歴） 2020年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2019年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2018年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード ストレス
性機能
性成熟
性行動
視床下部
GnRH
プロゲステロン受容体
テストステロン
出生後早期のストレス
長期的影響

研究成果

[学会発表] The reduction of sexual behavior in adult female rats exposed to immune stress in neonatal period was associated with reduced expression of progesterone receptors in hypothalamus

Toshiya Matsuzaki, Yiliyasi Mayila, Takeshi Iwasa, Kiyohito Yano, Rie Yanagihara and Minoru Irahara. 2019

[学会発表] シンポジウム：排卵障害動物モデルを用いたゴナドトロピン分泌異常に関する検討

松崎　利也 2019

[雑誌論文] Prenatal undernutrition affects the phenotypes of PCOS model rats

Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Mayila Yiliyasi、Yanagihara Rie、Yamamoto Yuri、Kuwahara Akira、Irahara Minoru 2018

[学会発表] The effects of chronic testosterone administration on body weight, food intake, and fat weight were changed age-dependently.

Takeshi Iwasa, Toshiya Matsuzaki, Rie Yanagihara, Mayila Yiliyasi, Kiyohito Yano, Minoru Irahara. 2018

[雑誌論文] Pregnancy outcomes of women who received conservative therapy for endometrial carcinoma or atypical endometrial hyperplasia

Matsuzaki Toshiya、Iwasa Takeshi、Kawakita Takako、Yamamoto Yuri、Abe Akiko、Hayashi Aki、Yano Kiyohito、Nishimura Masato、Kuwahara Akira、Irahara Minoru 2018

[雑誌論文] Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats

Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Yiliyasi Mayila、Kuwahara Akira、Matsui Sumika、Irahara Minoru 2018

[学会発表] Individualized initial dose in low-dose FSH therapy for WHO group 2 patients.

Rie Yanagihara, Toshiya Matsuzaki, Takeshi Iwasa, Kiyohito Yano, Minoru Irahara. 2018

[学会発表] Efficacy of individualized dose of FSH in ovarian stimulation for unexplained sterility.

Toshiya Matsuzaki, Rie Yanagihara, Kiyohito Yano, Takeshi Iwasa, Minoru Irahara. 2018

[雑誌論文] Prenatal undernutrition suppresses sexual behavior in female rats

Matsuzaki Toshiya、Munkhzaya Munkhsaikhan、Iwasa Takeshi、Tungalagsuvd Altankhuu、Yano Kiyohito、Mayila Yiliyasi、Yanagihara Rie、Tokui Takako、Kato Takeshi、Kuwahara Akira、Matsui Sumika、Irahara Minoru 2018

[雑誌論文] Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents

Matsuzaki Toshiya、Tungalagsuvd Altankhuu、Munkhzaya Munkhsaikhan、Iwasa Takeshi、Yano Kiyohito、Mayila Yiliyasi、Tokui Takako、Yanagihara Rie、Matsui Sumika、Kato Takeshi、Kuwahara Akira、Irahara Minoru 2018

[雑誌論文] Pilot study of the optimal protocol of low dose step-up follicle stimulating hormone therapy for infertile women

Matsuzaki Toshiya、Iwasa Takeshi、Yanagihara Rie、Komasaka Mizuki、Yano Kiyohito、Mayila Yiliyasi、Tachibana Ayaka、Yamamoto Yuri、Kato Takeshi、Kuwahara Akira、Irahara Minoru 2018

[雑誌論文] Prenatal undernutrition attenuates fasting-induced reproductive dysfunction in pre-pubertal male rats

Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Mayila Yiliyasi、Irahara Minoru 2018

[学会発表] 新しいプロトコールによるFSH低用量漸増療法の排卵誘発治療における効果と安全性の検討

松崎利也、柳原里江、岩佐　武、Mayila Yiliyasi、山本由理、桑原　章、苛原　稔 2018

[雑誌論文] Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms

Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Mayila Yiliyasi、Yanagihara Rie、Yamamoto Yuri、Kuwahara Akira、Irahara Minoru 2018

[雑誌論文] The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats

Mayila Yiliyasi、Matsuzaki Toshiya、Iwasa Takeshi、Tungalagsuvd Altankhuu、Munkhzaya Munksaihan、Yano Kiyohito、Yanagihara Rie、Tokui Takako、Kato Takeshi、Kuwahara Akira、Irahara Minoru 2018

[雑誌論文] Prenatal undernutrition decreases the anorectic response to septic doses of lipopolysaccharides in adulthood in male rats

Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Mayila Yiliyasi、Irahara Minoru 2018

[学会発表] The influence of early life psychological stress on sexual maturation and on sexual activity in female rats.

Kiyohito Yano, Toshiya Matsuzaki, Rie Yanagihara, Mayila Yiliyasi, Takeshi Iwasa, Minoru Irahra. 2018

[学会発表] ランチョンセミナー：排卵誘発におけるFSH製剤の安全な使い方

松崎利也 2018