トップ研究者を探す新規核内移行シグナル伝達調節物質による血管リモデリング、動脈硬化制御と治療戦略

新規核内移行シグナル伝達調節物質による血管リモデリング、動脈硬化制御と治療戦略

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18390235
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 愛媛大学
代表研究者 堀内 正嗣
研究分担者 岩井 將
研究分担者 茂木 正樹
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 18,060,000 (直接経費 :15,300,000、間接経費 :2,760,000)
配分額(履歴) 2008年度:5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000)
2007年度:6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000)
2006年度:6,100,000 (直接経費 :6,100,000)
キーワード レニン・アンジオテンシン系
受容体
血管リモデリング
動脈硬化
アンジオテンシンII
AT1受容体
AT2受容体
血管老化
シグナル伝達機構
転写調節

研究成果

[図書] Hypertension Res

Iwanami J, Mogi M, Iwai M, Horiuchi M 2009

[雑誌論文] Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes

Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, Okayama H, Mogi M, Higaki J, Horiuchi M 2009

[雑誌論文] Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists

Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, Okayama H, Mogi M, Higaki J, Horiuchi M 2009

[雑誌論文] Angiotensin-converting enzyme(ACE)and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

Kawajiri M, Mogi M, Higaki N, Matsuoka T, Ohyagi Y, Tsukuda K, Kohara K, Horiuchi M, Miki T, Kira J 2009

[図書] Hypertens Res

Iwanami J, Mogi M, Iwai M, Horiuchi M 2009

[図書] Current Opinion in Nephrology and Hypertension

Mogi M, Iwai M, Horiuchi M 2009

[雑誌論文] Attenuation of Cuff-Induced Neointimal Formation by Overexpression of Angiotensin II Type2 Receptor-Interacting Protein 1.

Fujita T, Mogi M, Min LJ, Iwanami J, Tsukuda K, Horiuchi M, et al. 2009

[雑誌論文] Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis.

Kawajiri M, Mogi M, Higaki N, Matsuoka T, Ohyagi Y, Horiuchi M, et al. 2009

[雑誌論文] Reduced angiotensin II levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Kawajiri M, Mogi M, Higaki N, Tateishi T, Ohyagi Y, Horiuchi M, et al. 2009

[雑誌論文] Attenuation of Cuff-Induced Neointimal Formation by Overexpression of Angiotensin II Type2 Receptor-Interacting Protein 1

Fujita T, Mogi M, Min LJ, Iwanami J, Tsukuda K, Sakata A, Okayama H, Iwai M, Nahmias C, Higaki J, Horiuchi M 2009

[雑誌論文] Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice

Inaba S, Iwai M, Furuno M, Tomono Y, Kanno H, Senba I, Okayama H, Mogi M, Higaki J, Horiuchi M 2009

[雑誌論文] Reduced angiotensin II levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Kawajiri M, Mogi M, Higaki N, Tateishi T, Ohyagi Y, Horiuchi M, Miki T, Kira JI. 2009

[雑誌論文] Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition.

Min LJ, Mogi M, Iwanami J, Li JM, Sakata A, Horiuchi M, et al. 2008

[雑誌論文] Akt-FOXO3a signaling affects human endothelial progenitor cell differentiation

Mogi M, Walsh K, Iwai M, Horiuchi M 2008

[雑誌論文] Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis.

Kawajiri M, Mogi M, Osoegawa M, Matsuoka T, Tsukuda K, Horiuchi M, et al. 2008

[雑誌論文] Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis

Kawajiri M, Mogi M, Osoegawa M, Matsuoka T, Tsukuda K, Kohara K, Horiuchi M, Miki T, Kira JI 2008

[雑誌論文] Telmisartan prevented cognitive decline partly due to PPAR-gamma activation

Mogi M, Li JM, Tsukuda K, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M 2008

[雑誌論文] Attenuation of focal brain ischemia by telmisartan, an angiotensin II type 1 receptor blocker, in atherosclerotic apolipoprotein E-deficient mice

Iwai M, Inaba S, Tomono Y, Kanno H, Iwanami J, Mogi M, Horiuchi M 2008

[雑誌論文] Angiotensin II Type 2 Receptor Deletion Enhances Vascular Senescence by Methy1 Methanesulfonate Sensitive 2 Inhibition

Min, L-J., Mogi, M., Iwanami, J., Li, J-M., Sakata, A., Fujita, T., et. al. 2008

[図書] Ageing Res Rev

Min LJ, Mogi M, Iwai M, Horiuchi M. 2008

[雑誌論文] Telmisartan prevented cognitive decline partly due to PPAR-gamma activation.

Mogi M, Li JM, Tsukuda K, Iwanami J, Min LJ, Horiuchi M, et al. 2008

[雑誌論文] Akt-FOX03a signaling affects human endothelial progenitor cell differentiation.

Mogi M, Walsh K, Iwai M, Horiuchi M, et al. 2008

[雑誌論文] Attenuation of focal brain ischemia by telmisartan,an angiotensin II type 1 receptor blocker, in atherosclerotic apolipoprotein E-deficient mice

Iwai, M., Inaba, S., Tomono, Y., Kanno, H., Iwanami, J., Mogi, M., et. al. 2008

[雑誌論文] Diabetes-associated cognitive impairment is improved by a calcium channel blocker,nifedipine

Tsukuda, K., Mogi, M., Li, J-M., Iwanami, J., Min, L-J., Sakata, A., et. al. 2008

[図書] Ageing Res Rev

Min LJ, Mogi M, Iwai M, Horiuchi M 2008

[雑誌論文] Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density.

Li JM, Mogi M, Iwanami J, Min LJ, Tsukuda K, Horiuchi M, et al. 2008

[雑誌論文] Temporary pretreatment with the angiotensin II type 1 receptor blocker, valsartan, prevents ischemic brain damage through an increase in capillary density

Li JM, Mogi M, Iwanami J, Min LJ, Tsukuda K, Sakata A, Fujita T, Iwai M, Horiuchi M 2008

[雑誌論文] Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine.

Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Horiuchi M, et al. 2008

[図書] Hypertens Res

Mogi M, Horiuchi M. 2008

[雑誌論文] Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition

Min LJ, Mogi M, Iwanami J, Li JM, Sakata A, Fujita T, Tsukuda K, Iwai M, Horiuchi M 2008

[雑誌論文] Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models

Tomono Y, Iwai M, Inaba S, Mogi M, Horiuchi M 2008

[雑誌論文] Deletion of angiotensin II type 2 receptor attenuates protective effects of bone marrow stromal cell treatment on ischemia-reperfusion brain injury in mice.

Iwanami J, Mogi M, Li JM, Tsukuda K, Min LJ, Horiuchi M, et al. 2008

[雑誌論文] Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule

Shigenaga A, Tamura K, Wakui H, Masuda S, Azuma K, Tsurumi-Ikeya Y, Ozawa M, Mogi M, Matsuda M, Uchino K, Kimura K, Horiuchi M, Umemura S 2008

[雑誌論文] Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine

Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M 2008

[雑誌論文] Deletion of Angiotensin II Type 2 Receptor Attenuates Protective Effects of Bone Marrow Stromal Cell Treatment on Ischemia Reperfusion Brain Injury in Mice

Iwanami, J., Mogi, M., Li, J-M., Tsukuda, K., Min, L-J. Sakata, A., et. al. 2008

[雑誌論文] Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models.

Tomono Y, Iwai M, Inaba S, Mogi M, Horiuchi M. 2008

[雑誌論文] Temporary Pretreatment with Angiotensin II Type 1 Receptor Blocker,Valsartan,Prevents Ischemic Brain Damage via Increase in Capillary Density

Li, J-M., Mogi, M., Iwanami, J., Min, L-J., Tsukuda, K., Sakata, A., et. al. 2008

[図書] Hypertens Res

Mogi M, Horiuchi M 2008

[雑誌論文] Deletion of angiotensin II type 2 receptor attenuates protective effects of bone marrow stromal cell treatment on ischemia-reperfusion brain injury in mice

Iwanami J, Mogi M, Li JM, Tsukuda K, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M 2008

[学会発表] Diabetes-associated cognitive impairment is improved by angiotensin II type 1 receptor blocker, candesartan

Tsukuda, K., Mogi, M., Li-M., Iwanami, J., Min, L-J., Sakata, A., et. al. 2007

[雑誌論文] Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan

Mogi M, Tsukuda K, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M 2007

[学会発表] 高食塩・高脂肪食負荷で認められた認知機能の低下に対するオルメサルタンとアゼルニジピンの効果

佃架 奈、茂木 正樹、岩井 将、堀内 正嗣 2007

[学会発表] Angiotensin II type 1 receptor blocker, olmesartan, ameliorares metabolic syndrome-induced cognitive impairment in mouse models

Mogi, M., Tsukuda, K., Li, J-M., Iwanami, J., Min, L-J., Sakata, A., et. al. 2007

[学会発表] 血管平滑筋細胞の老化におけるアンジオテンシンII2型受容体の役割についての検討-MMS2によるDNA修復機構の関与

茂木 正樹、閔 莉娟、岩井 将、堀内 正嗣 2007

[図書] Arterioscler Thromb Vasc Biol

Mogi M, Iwai M, Horiuchi M 2007

[雑誌論文] Attenuation of monocyte chemoattractant protein-1 expression via inhibition of nuclear factor-kappaB activity in inflammatory vascular injury

Gao X, Iwai M, Inaba S, Tomono Y, Kanno H, Mogi M, Horiuchi M 2007

[雑誌論文] Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence

Min LJ, Mogi M, Iwanami J, Li JM, Sakata A, Fujita T, Tsukuda K, Iwai M, Horiuchi M 2007

[雑誌論文] Amelioration of cognitive impairment in the type-2 diabetic mouse by the angiotensin II type-1 receptor blocker candesartan

Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M 2007

[雑誌論文] Amelioration of cognitive impairment in the type-2 diabetic mouse by the angiotensin II type-1 receptor blocker candesartan

Tsukuda, K., Mogi, M., Li, J-M., Iwanami, J., Min, L-J., Sakata, A., et. al. 2007

[雑誌論文] Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence

Min, L-j., Mogi, M., Iwanami, J., Li, J-M., Sakata, A., Fujita, T., et. al. 2007

[学会発表] Angiotensin II type-2 receptor stimulation induces neural differentiation by ubiquitin proteasome system via a neuroprotective factor,MMS2

Mogi, M., Li, J-M., Iwanami, J., Min, L-J., Tsukuda, K., Sakata, A., et. al. 2007

[雑誌論文] Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model

Iwanami J, Mogi M, Okamoto S, Gao XY, Li JM, Min LJ, Ide A, Tsukuda K, Iwai M, Horiuchi M 2007

[雑誌論文] Angiotensin II-induced neural differentiation via AT2 receptor-MMSII cascade involving interaction between AT2 receptor-interacting protein (ATIP)and SHP-1.

Li, J-M., Mogi, M., Tsukada, K., Tmochika, H., Iwanami, H., et al. 2007

[学会発表] New Protective Role of AT2 Receptor Stimulation in Vascular Smooth Muscle Cell Senescence Involving Methy1 Methanesulfonate Sensitive 2

Mogi, M, Masatugu, H 2007

[学会発表] Diabetes-Associated Cognitive Impairment Is Improved by a Calcium Channel Blocker,Nifedipine

Tsukuda, K., Mogi, M., Li, J-M., Iwanami, J., Min, L-J., et. al. 2007

[雑誌論文] Angiotensin II-induced neural differentiation via angiotensin II type 2(AT2)receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1

Li JM, Mogi M, Tsukuda K, Tomochika H, Iwanami J, Min LJ, Nahmias C, Iwai M, Horiuchi M 2007

[雑誌論文] Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model

Iwanami, J., Mogi, M., Okamoto, S., Gao, X-Y., Li, J-M., Min, L-J., et. al. 2007

[雑誌論文] Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan

Iwai M, Li HS, Chen R, Shiuchi T, Wu L, Min LJ, Li JM, Tsuda M, Suzuki J, Tomono Y, Tomochika H, Mogi M, Horiuchi M 2006

[雑誌論文] Attenuation of inflammatory vascular remodeling by angiotensin II type 1 receptor-associated protein

Oshita A, Iwai M, Chen R, Ide A, Okumura M, Fukunaga S, Yoshii T, Mogi M, Higaki J, Horiuchi M 2006

[雑誌論文] The calcium-channel blocker, azelnidipine, enhances the inhibitory action of AT1 receptor blockade on ischemic brain damage

Iwai M, Chen R, Ide A, Iwanami J, Tomochika H, Tomono Y, Mogi M, Horiuchi M 2006

[雑誌論文] Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions

Yoshii T, Iwai M, Li Z, Chen R, Ide A, Fukunaga S, Oshita A, Mogi M, Higaki J, Horiuchi M 2006

[雑誌論文] Amlodipine treatment reduces stroke size apolipoprotein E-deficient mice.

Mogi, M., Iwai, M., Chen, R., Iwanami, J., Ide, A., Tsukada, K., et al. 2006

[図書] Role of NAD(P)H oxidase and its regulation in chronic hypertension

Iwai M, Mogi M, Horiuchi M 2006

[雑誌論文] Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation

Suzuki J, Iwai M, Mogi M, Oshita A, Yoshii T, Higaki J, Horiuchi M 2006

[図書] Hypertension

Mogi M, Iwai M, Horiuchi M 2006

[雑誌論文] Comparison of inhibitory action of candesartan and enalapril on brain ischemia through inhibition of oxidative stress

Hamai M, Iwai M, Ide A, Tomochika H, Tomono Y, Mogi M, Horiuchi M 2006

[雑誌論文] Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2

Mogi M, Li JM, Iwanami J, Min LJ, Tsukuda K, Iwai M, Horiuchi M 2006

[雑誌論文] Amlodipine treatment reduces stroke size in apolipoprotein E-deficient mice

Mogi M, Iwai M, Chen R, Iwanami J, Ide A, Tsukuda K, Yoshii T, Horiuchi M 2006

[図書] Endocr J

Horiuchi M, Mogi M, Iwai M 2006

[雑誌論文] Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression : involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase

Wu L, Iwai M, Li Z, Li JM, Mogi M, Horiuchi M 2006

[図書] Hypertension

Mogi M, Iwai M, Horiuchi M 2006

[雑誌論文] Angiotensin II type-2 receptor stimulation prevents neural damage y transcriptional activatiom of methyl methanesulfonate sensitive 2.

Mogi, M., Li, J-M., Iwanami.J., Min, L-J., Tsukuda, K., et al. 2006