トップ研究者を探す網膜解毒機構としての網膜関門排出輸送担体の同定と生理的役割

網膜解毒機構としての網膜関門排出輸送担体の同定と生理的役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18390048
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
薬学
医療系薬学
研究機関 富山大学
代表研究者 細谷 健一
研究分担者 立川 正憲
研究分担者 畑中 保丸
研究分担者 水口 峰之
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 17,630,000 (直接経費 :15,200,000、間接経費 :2,430,000)
配分額(履歴) 2007年度:10,530,000 (直接経費 :8,100,000、間接経費 :2,430,000)
2006年度:7,100,000 (直接経費 :7,100,000)
キーワード 血液網膜関門
マイクロダイアリシス法
oatp
OAT
排出輸送
estradiol17-βglucuronide
ρ-aminohippuric acid
免疫染色
p-aminohiuric acid
有機アニオン輸送担体
estradiol 17-β glucuronide
dehydroepiandrosterone sulfate
Oatp
Blood-retinal barrier
Microdialysis
oatp
OAT
Efflux transport
Estradiol 17-β glucuronide
p-Aminohippuric acid

研究成果

[雑誌論文] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells

M, Tachikawa, H, Toki, M, Tomi, K, Hosoya 2008

[雑誌論文] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells

M. Tachikawa 2008

[雑誌論文] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells

M. Tachikawa 2008

[雑誌論文] Na^+-independent choline transport in rat retinal capillary endothelial cells

M, Tomi, K, Arai, M, Tachikawa, K, Hosoya 2007

[学会発表] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier.

M. Tachikawa 2007

[雑誌論文] Functional involvement of scavenger receptor class B, type I, in the uptake of α-tocopherol using cultured rat retinal capillary endothelial cells.

M. Tachikawa 2007

[学会発表] Involvement of transporters in the retina-to-blood efflux transport of organic anions at the inner blood-retinal barrier

K, Hosoya, A. Makihara, Y, Ohshima, K, Katayama, M, Tomi, M, Tachikawa 2007

[学会発表] The role of scavenger receptor class B type I(SR-BI) in vitamin E uptake at the inner blood-retinal barrier

S, Okayasu, M, Tachikawa, K, Hosoya 2007

[学会発表] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier

M, Tachikawa, M, Toki, M, Tomi, K, Hosoya 2007

[雑誌論文] Functional involvement of scavenger receptor class B, type I, in the upt ake of α-tocopherol using cultured rat retinal capillary endothelial cells

M. Tachikawa 2007

[学会発表] The role of reduced folate transporter1(RTF1) in methyletrahydrofolate transport at the inner blood-retinal barrier

K, Fujita, M, Tachikawa, K, Hosoya 2007

[雑誌論文] Functional involvement of scavenger receptor class B, type I, in the uptake of a-tocopherol using cultured rat retinal capillary endothelial cells

M, Tachikawa, S, Okayasu, K, Hosoya 2007

[雑誌論文] Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier

K, Nagase, M, Tomi, M, Tachikawa, K, Hosoya 2006