トップ›研究者を探す›C型肝炎ウイルス複製モデルを用いた持続感染機序の解明および治療法の探究

C型肝炎ウイルス複製モデルを用いた持続感染機序の解明および治療法の探究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17590650
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 愛媛大学
代表研究者 日浅 陽一
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額（合計） 3,400,000 (直接経費 :3,400,000)
配分額（履歴） 2006年度：1,500,000 (直接経費 :1,500,000)
2005年度：1,900,000 (直接経費 :1,900,000)
キーワード C型肝炎ウイルス
複製モデル
PKR
インターフェロン
リバビリン
IL-8
T細胞
持続感染
抗HCV治療
EVR
Hepatitis C virus
HCV replication model
Protein kinase R
Interferon
Ribavirin
Interleukin-8
T cell
anti-HCV therapy

研究成果

[雑誌論文] Heterogeneity of hepatitis B virus genotype D in Japan.

Michitaka K, Horiike N, Duong TN, Yagura M, Harada H, Shibayama T, Inui A, Fujisawa T, Matsuura K, Hiasa Y, Onji M. 2007

[雑誌論文] Identification of CIL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Mashiba T, Udaka K, Hirachi Y, Hiasa Y, Miyakawa T, et al. 2007

[雑誌論文] Impaired dendritic cell function resulting from chronic undernutrition disrupts the antigen-specific immune response in mice.

Niiiya T, Akbar SM, Yoshida 0, Miyake T, Hiasa Y, Onji M, et a1. 2007

[雑誌論文] identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Mashiba T, Udaka K, Hirachi Y, Hiasa Y, Miyakawa T, et a1. 2007

[雑誌論文] Impaired dendritic cell function resulting from chronic undernutri t ion disrupts the antigen-specific immune response in mice.

Niiya T, Akbar SM, Yoshida 0, Miyake T, Matsuura B, Murakami H, Abe M, Hiasa Y, Onji M. 2007

[雑誌論文] Heterogeneity of hepatitis B virus genotype D in Japan.

Michitaka K, Horiike N, Duong TN, Yagura M, Hiasa Y, Onji M, et al. 2007

[雑誌論文] Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Mashiba T, Udaka K, Hirachi Y, Hiasa Y, Miyakawa T, Satta Y, Osoda T, Kataoka S, Kohara M, Onji M. 2007

[雑誌論文] Dietary habits and nutrient intake in non-alcoholic steatohepatitis.

Toshimitsu K, Matsuura B, Ohkubo I, Niiya T, Hiasa Y, Onji M, et al. 2007

[雑誌論文] Impaired dendritic cell function resulting from chronic undernutrition disrupts the antigen-specific immune response in mice.

Niiya T, Akbar SM, Yoshida O, Miyake T, Hiasa Y, Onji M, et al. 2007

[雑誌論文] Dietary habits and nutrient intake in non-alcoholic steatohepatitis.

Toshimitsu K, Matsuura B, Ohkubo I, Niiya T, Furukawa S, Hiasa Y, Kawamura M, Ebihara K, Onji M. 2007

[雑誌論文] Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication.

Hiasa Y, Blackard JT, Lin W, Kamegaya Y, et al. 2006

[雑誌論文] Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment.

Hiraoka A, Kumagi T, Hirooka M, Uehara T, Hiasa Y, Onji M, et al. 2006

[雑誌論文] Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment.

Hiraoka A, Kumagi T, Hirooka M, Uehara T, Kurose K, Iuchi H, Hiasa Y, Matsuura B, Michitaka K, Kumano S, Tanaka H, Yamashita Y, Horiike N, Mochizuki T, Onji M. 2006

[雑誌論文] Understanding the precise function of interferon regulatory factor 3 in hepatitis C virus replication will lead to a new strategy for therapy.

Hiasa Y, Onji M 2006

[雑誌論文] Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices.

Murata Y, Abe M, Furukawa S, Kumagi T, Matsui H, Matsuura B, Hiasa Y, Onji M. 2006

[図書] 消化器疾患ガイドライン-最新の診療指針-

日浅陽一, 恩地森一 2006

[雑誌論文] Tracing the history of hepatitis B virus genotype D in western Japan.

Michitaka K, Tanaka Y, Horiike N, Duong TN, Hiasa Y, et al. 2006

[雑誌論文] Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices.

Murata Y, Abe M, Furukawa S, Kumagi T, Matsui H, Hiasa Y, Onji M, et al. 2006

[雑誌論文] Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication.

Hiasa Y, Blackard JT, Lin W, Kamegaya Y, Horiike N, Onji M, Schmidt EV, Chung RT. 2006

[雑誌論文] Understanding the precise function of interferon regulatory factor 3 in hepatitis C virus replication will lead to a new strategy for therapy.

Hiasa Y, Onji M. 2006

[雑誌論文] Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices.

Murata Y, Abe M, Furukawa S, Kumagi T, Hiasa Y, Onji M, et al. 2006

[図書] 消化器疾患ガイドライン -最新の診療指針-

日浅陽一, 恩地森一 2006

[雑誌論文] Tracing the history of hepatitis B virus genotype D in western Japan.

Michitaka K, Tanaka Y, Horiike N, Duong TN, Chen Y, Matsuura K, Hiasa Y, Mizokami M, Onji M. 2006

[雑誌論文] In vivo immunization by vaccine therapy following virus suppression by lamivudine : a novel approach for treating patients with chronic hepatitis B.

Horiike N, Akbar SMF, Michitaka K, Joukou K, Yamamoto K, Kojima N, Hiasa Y, Abe M, Onji M. 2005

[雑誌論文] Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons.

Blackard JT, Smeaton L, Hiasa Y, Horiike N, Onji M, et al. 2005

[雑誌論文] Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons.

Blackard JT, Smeaton L, Hiasa Y, Horiike N, Onji M, Jamieson DJ, Rodriguez I, Mayer KH, Chung RT. 2005

[雑誌論文] Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.

Lin W, Choe WH, HIasa Y, Kamegaya Y, Blackaro JT, Schmidt EV, Chung RT. 2005

[図書] 肝臓フォーラム '04記録集 T7ポリメラーゼによるHCV長期発現モデルの作成と抗ウイルス薬の評価

日浅陽一 2005

[雑誌論文] Co-infection with hepatitis B virus genotype D and other genotypes in Western Japan.

Michitaka K, Horiike N, Chen Y, Duong TN, Matsuura K, Hiasa Y, et al. 2005

[雑誌論文] Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.

Kamegaya Y, Hiasa Y, Zukerberg L, Fowler N, Blackard JT, Lin W, Choe WH, Schmidt EV, Chung RT. 2005

[図書] 肝臓フォーラム ‘04記録集 T7ポリメラーゼによるHCV長期発現モデルの作成と抗ウイルス薬の評価

日浅陽一 2005

[雑誌論文] The quantification of cytochrome P-450 (CYP 3A4) mRNA in the blood of patients with viral liver diseases.

Horiike N, Abe M, Kumagi T, Hiasa Y, Akbar SM, Michitaka K, Onji M. 2005

[雑誌論文] Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.

Lin W, Choe WH, Hiasa Y, Kamegaya Y, Blackard JT, Schmidt EV, Chung RT. 2005

[雑誌論文] In vivo immunization by vaccine therapy following virus suppression by lamivudine : a novel approach for treating patients with chronic hepatitis B.

Horiike N, Akbar SMF, Michitaka K, Joukou K, Yamamoto K, Hiasa Y, et al. 2005

[雑誌論文] Hepatisis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.

Kamegaya Y, Hiasa Y, Zukerberg L, Fowler N, Blackard JT, et al. 2005

[雑誌論文] Administration of dendritic cells in cancer nodules in hepatocellular carcinoma.

Kumagi T, Akbar SM, Horiike N, Kurose K, Hiasa Y, et al. 2005

[雑誌論文] Hepatisis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.

Kamegaya Y, Hiasa Y, Zukerberg L., Fowler N, Blackard JT, et al. 2005