トップ›研究者を探す›造血器腫瘍に対する新たな免疫遺伝子療法の開発

造血器腫瘍に対する新たな免疫遺伝子療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17390278
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 愛媛大学
代表研究者 安川 正貴
研究分担者 薬師神 芳洋
研究分担者 酒井 郁也
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額（合計） 14,600,000 (直接経費 :14,600,000)
配分額（履歴） 2006年度：5,900,000 (直接経費 :5,900,000)
2005年度：8,700,000 (直接経費 :8,700,000)
キーワード 造血器腫瘍
がん免疫
細胞傷害性T細胞
がんペプチドワクチン
遺伝子治療
白血病
免疫療法
hematopoietic malignancies
cancer immunity
cytotoxic T lymphocyte
cancer peptide vaccine
gene therapy

研究成果

[雑誌論文] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT-specific cytotoxic T lymphocytes.

Fujiki F, Yasukawa M, et al. 2007

[雑誌論文] Therole of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.

Ikeda K, Yasukawa M, et al. 2007

[図書] 造血器腫瘍 「細胞免疫療法(総論)」

安川正貴 2007

[図書] 造血器腫瘍 「細胞免疫療法(各論)」

安川正貴 2007

[雑誌論文] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.

Ikeda K, Yasukawa M, et al. 2007

[雑誌論文] 日本臨床社

安川正貴 2007

[雑誌論文] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.

Fujiki F, Yasukawa M, et al. 2007

[図書] 「血球貪食症候群」 今日の治療指針2007年版 -私はこう治療している-

安川正貴 2007

[雑誌論文] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.

Ikeda K, Yasukawa M, et al. 2007

[雑誌論文] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.

Fujiki F, Yasukawa M, et al. 2007

[雑誌論文] Antagosist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice.

Hasegawa H, Yasukawa M, et al. 2006

[雑誌論文] Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

Kohno M, Yasukawa M, et al. 2006

[図書] 「慢性リンパ性白血病」 今日の治療指針2006年版 -私はこう治療している-

安川正貴 2006

[雑誌論文] IK cytokine ameliorates the progression of lupus nephritis in MRL/1pr mice.

Muraoka M, Yasukawa M, et al. 2006

[図書] ヘルペスウイルス学「HHV-6,HHV-7感染に対する免疫応答」

安川正貴 2006

[雑誌論文] IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice.

Muraoka M, Yasukawa M, et al. 2006

[雑誌論文] Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

Kohno M, Yasukawa M, et al. 2006

[雑誌論文] Antagosist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/1pr mice.

Hasegawa H, Yasukawa M, et al. 2006

[雑誌論文] Identification of critical residues for regulation of integrin activation in the beta6-alpha7 loop of the integrin beta3 I-like domain.

Hato T, Yasukawa M, et al. 2006

[雑誌論文] Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells.

Niiya H, Yasukawa M, et al. 2006

[雑誌論文] IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice.

MuraokaM, Yasukawa M, et al. 2006

[雑誌論文] Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells.

Niiya H, Yasukawa M, et al. 2006

[雑誌論文] Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

Kohno M, Yasukawa M, et al. 2006

[雑誌論文] Human cord blood-derived cells generate insulin-producing cells in vivo.

Yoshida S, Yasukawa M, et al. 2005

[図書] Focus on Leukemia Research

Yasukawa M 2005

[雑誌論文] Development of functional human blood and immune system in NOD/SCID/IL2 receptor Y chain^<null> mice

Ishikawa F, Yasukawa M, et al. 2005

[雑誌論文] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.

Osawa H, Yasukawa M, et al. 2005

[雑誌論文] Expression of SOCS3 in bone marrow cells from chronic myelogenous leukemia patients is associated with the cytogenetic response to interferon-alpha.

Takeuchi K, Yasukawa M, et al. 2005

[雑誌論文] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people.

Yamamoto K, Yasukawa M, et al. 2005

[雑誌論文] Genetic subtypes of familial hemophagocytic lymphohistiocytosis correlations with clinical features and cytotoxic T lymphocyte/naturalkiller cell functions

Ishii E, Yasukawa M, et al. 2005

[雑誌論文] Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCIS/□2-microglobulin^<null> mice

Kawano N, Yasukawa M, et al. 2005

[雑誌論文] Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/・2-microglobulin^<null> mice.

Kawano N, Yasukawa M, et al. 2005

[雑誌論文] Expression of SOCS3 in bone marrow cells from chronic myelogenous leukemia patients is associated with the cytogenetic response to interferon-alpha.

Takeuchi K, Yasukawa M, et al. 2005

[雑誌論文] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people.

Yamamoto K, Yasukawa M, et al. 2005

[雑誌論文] Genetic subtypes of familial hemophagocytic lymphohistiocytosis : correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions.

Ishii E, Yasukawa M, et al. 2005

[雑誌論文] Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain^<null> mice.

Ishikawa F, Yasukawa M, et al. 2005

[雑誌論文] Generation of human tumor-specific, HLA class I-restricted Thl and Tcl cells by cell engineering with tumor peptide-specific TCR genes.

Tsuji T, Yasukawa M, et al. 2005

[雑誌論文] Generation of human tumor-specific, HLA class I-restricted Th1 and Tc1 cells by cell engineering with tumor peptide-specific T cell receptor genes.

Tsuji T, Yasukawa M, et al. 2005

[雑誌論文] Human cord blood-derived cells generate insulin-producing cells in vivo

Yoshida S, Yasukawa M, et al. 2005

[雑誌論文] Direct recognition and lysis of leukemia cells by WT1-specific CD4^+ T lymphocytes in an HLA class II-restricted manner.

Guo Y, Yasukawa M, et al. 2005

[雑誌論文] Differential regulation of perforin expression in CD4^+ and CD8^+ cytotoxic T lymphocytes.

Niiya H, Yasukawa M, et al. 2005

[雑誌論文] Direct recognition and lysis of leukemia cells by WT1-specific CD4^+T lymphocytes in an HLA cldass II-restricted manner

Guo Y, Yasukawa M, et al. 2005

[雑誌論文] Generation of human tumor specific, HLA class Th1 and Tc1 cells by cell engineering with tumor peptide-specific T cell receptor genes

Tsuji T, Yasukawa M, et al. 2005

[雑誌論文] Novel AML1-MEL1 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22).

Sakai I, Yasukawa M, et al. 2005

[雑誌論文] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.

Osawa H, Yasukawa M, et al. 2005

[雑誌論文] Differential regulation of perforin expression in CD4^+ and CD8^+ cytotoxic T lymphocytes.

Niiya H, Yasukawa M, et al. 2005