トップ研究者を探す骨格系のホメオスターシス維持と病態発症に関わる分子制御機構の解明と治療法の開発

骨格系のホメオスターシス維持と病態発症に関わる分子制御機構の解明と治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17209035
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
内科系臨床医学
内分泌学
研究機関 徳島大学
代表研究者 松本 俊夫
研究分担者 安倍 正博
研究分担者 赤池 雅史
研究分担者 木戸 慎介
研究分担者 井上 大輔
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 47,450,000 (直接経費 :36,500,000、間接経費 :10,950,000)
配分額(履歴) 2007年度:14,430,000 (直接経費 :11,100,000、間接経費 :3,330,000)
2006年度:14,430,000 (直接経費 :11,100,000、間接経費 :3,330,000)
2005年度:18,590,000 (直接経費 :14,300,000、間接経費 :4,290,000)
キーワード 力学的負荷
IL-11
ΔFosB
骨髄腫
Wnt
血管新生
グルココルチコイド
血管内皮機能
g
DeltaFosB
Mechanical stress
Interleukin-11 (IL-11)
AFosB
Multiple myeloma
Wnt signal
Angiogenesis
Gluencorticoid
Endothelial cells

研究成果

[学会発表] Cancer Treatment-induced Bone Diseases and Their Management

Matsumoto, T 2007

[学会発表] ホルモン依存癌治療における骨病変とその管理

Toshio Matsumoto 2007

[学会発表] Bone Remodeling and Treatment of Osteoporosis

Matsumoto, T 2007

[学会発表] Pathophysiology of Osteoporosis

Toshio Matsumoto 2007

[学会発表] Genetics of bone metabolism

Matsumoto, T 2007

[学会発表] Therapeutic Opportunities Mechanism and Therapeutics in Myeloma Bone Disease

Toshio Matsumoto 2007

[学会発表] Mechanism and Therapeutics in Myeloma Bone Disease

Matsumoto, T 2007

[学会発表] SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING USA

Matsumoto, T 2007

[雑誌論文] ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.

Matsumoto T 2007

[学会発表] Bone Remodeling and Treatment of Osteoporosis

Toshio Matsumoto 2007

[学会発表] 骨と遺伝子・骨代謝メカニズム

Toshio Matsumoto 2007

[学会発表] Therapeutic Opportunities Mechanism and Therapeutics in Myeloma Bone Disease

Toshi Matsumoto 2007

[学会発表] Interaction between Smad and AP-1 signaling

Toshio Matsumoto 2007

[学会発表] SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE,AND AGING

Toshio Matsumoto 2007

[雑誌論文] ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects

Matsumoto, T., et. al. 2007

[学会発表] The Korean Society of Osteoporosis

Matsumoto, T 2007

[学会発表] Mechanical Stress-Induced signaling of osteoblast Differentiation -Interaction Between Smad and AP-1 signaling-

Matsumoto, T 2007

[学会発表] Mechanical stress-induced signaling of Osteoblast Differentiation-Interaction between Smad and AP-1 signaling-

Toshio Matsumoto 2007

[学会発表] Bone Remodeling and Treatment of Osteoporosis

Toshio Matsumoto 2007

[雑誌論文] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma

Abe M 2006

[雑誌論文] Skeletal Development and Remodeling

Matsumoto TAbe, M. 2006

[雑誌論文] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells : a rationale for TACI-Fc treatment in patients with multiple myeloma

Abe, M., et. al. 2006

[雑誌論文] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells : a rationale for TACI-Fc treatment in patients with multiple myeloma

Abe M 2006

[雑誌論文] Daily nasal spray of hPTH (1-34) for 3 months increases bone mass in osteoporotic subjects: a pilot study

Matsumoto T 2006

[学会発表] MIP-1 PRODUCED BY MYELOMA CELLS ENHANCES BONE DESTRUCTION,MYELOMA CELL SURVIVAL,AND SUPPRESSES DENDRITIC CELL FORMATION

Toshio Matsumoto 2006

[雑誌論文] Parkin enhances mitochondria] biogenesis in proliferating cells

Kuroda, Y., Azuma H, Matsumoto, T, et. al. 2006

[雑誌論文] Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects : a pilot study

Matsumoto T 2006

[雑誌論文] Bone destruction in multiple myeloma.

Matsumoto T 2006

[雑誌論文] Bone destruction in multiple myeloma

Matsumoto, T., et. al. 2006

[学会発表] MIP-1 PRODUCED BY MYELOMA CELLS Bone ENHANCES BONE DESTRUCTION, MYELOMA CELL SURVIVAL, AND SUPPRESSES DENDRITIC CELL FORMATION

Matsumoto, T 2006

[雑誌論文] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi) Bone destruction in multiple myeloma

Matsumoto, T 2006

[雑誌論文] Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects : a pilot study

Matsumoto, T., et. al. 2006

[図書] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi)

Matsumoto T 2006

[図書] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi) Bone destruction in multiple myeloma

Matsumoto, T 2006

[雑誌論文] Myeloma-Bone Interaction : A Vicious Cycle.

Matsumoto T 2006

[雑誌論文] A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Matsumoto, T., et. al. 2005

[雑誌論文] A New Active Vitamin D, ED-71,Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double Blind, Placebo-controlled Clinical Trial.

Matsumoto T 2005

[雑誌論文] A New Active Vitamin D,ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation : A Randomized, Double Blind, Placebo-controlled Clinical Trial.

Matsumoto T 2005

[雑誌論文] Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma

Jalili, A., NishiokaY, Matsumoto, T, et. al. 2005

エリスロポエチンを用いた虚血性疾患の治療

抗HLA抗体を利用した新規医薬品

抗HLA抗体を利用した新規医薬品

HLAクラスIを認識する抗体を有効成分として含有する化学療法剤耐性癌治療剤、およびその利用