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赤池雅史

徳島大学

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2024年11月14日更新

職名: 教授
電話: 088-633-9104
電子メール: akaike.masashi@tokushima-u.ac.jp
学歴: 1985/3: 徳島大学医学部医学科卒業
学位: 博士(医学) (徳島大学) (1992年7月)
職歴・経歴: 〜: 徳島大学助手, 病院 (-2006.4.)
2006/5: 徳島大学講師, 病院 (-2007.12.)
2008/1: 徳島大学講師, 大学院ヘルスバイオサイエンス研究部 (-2008.6.)
2008/7: 徳島大学准教授, 大学院ヘルスバイオサイエンス研究部 (-2010.11.)
2010/12: 徳島大学教授, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学教授, 大学院医歯薬学研究部

専門分野・研究分野: 医学 (Medicine)

研究者総覧で最新データを確認する

2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
担当経験のある授業科目: CBT/OSCE (学部)
アカデミックプレゼンテーション (大学院)
オリエンテーション(1年) (学部)
オリエンテーション(2年) (学部)
オリエンテーション(3年) (学部)
オリエンテーション(4年) (学部)
オリエンテーション(5年生) (学部)
オリエンテーション(6年生) (学部)
ゲノム創薬特論 (大学院)
コミュニケーション特論 (大学院)
チーム医療論 (学部)
ヒューマンサイエンス(形態と機能) (大学院)
ヒューマンサイエンス(病理病態学) (大学院)
プロテオミクス概論 (大学院)
人間栄養学特論 (大学院)
健康食品・漢方 (大学院)
医学英語 (学部)
医療教育学 (大学院)
医療教育学演習 (大学院)
医療栄養学特論 (大学院)
医療系分野における知的財産学概論 (大学院)
国際栄養学特論 (大学院)
国際栄養学特論/International Nutrtiion (大学院)
国際統合医療特論 (大学院)
国際統合医療特論(Global Topics of Interdisciplinary Health Care) (大学院)
宇宙と栄養・医学概論 (大学院)
循環器コース(3年) (学部)
微生物・免疫学実習 (大学院)
心身健康と環境ストレス (大学院)
指定学外実習Ⅰ (学部)
指定学外実習Ⅱ (学部)
生命倫理概論 (大学院)
生命科学の研究手法 (大学院)
生命科学の研究手法 (Basic methods in life sciences) (大学院)
生命科学コミュニケーション特論 (大学院)
生命科学コミュニケーション特論 (Communication Know-How) (大学院)
社会医学・疫学・医学統計概論 (大学院)
社会医学・疫学・医学統計概論 (Introduction to social medicine,epidemiology and biostatistics) (大学院)
社会環境医学実験実習・臨床研究実習 (大学院)
系統別病態診断 (学部)
臨床医学入門コース (学部)
臨床医学概論 (大学院)
臨床医科学概論 (大学院)
臨床実習入門 (学部)
臨床実習入門(チーム医療・診療現場見学実習) (学部)
臨床実習入門(内科診断学実習) (学部)
臨床実習入門(基本的診療技能実習) (学部)
臨床実習入門(講義) (学部)
臨床実習後OSCE (学部)
臨床心理学 (大学院)
臨床薬理学概論 (大学院)
英語論文作成法 (大学院)
英語論文作成法 (Introduction to How to Write Up Scientific Manuscript in English) (大学院)
診療参加型臨床実習Ⅱ (学部)
診療参加型臨床実習Ⅱ(第1ブロック) (学部)
診療参加型臨床実習Ⅱ(第2ブロック) (学部)
診療参加型臨床実習Ⅱ(第3ブロック) (学部)
診療参加型臨床実習Ⅱ(第4ブロック) (学部)
診療参加型臨床実習Ⅱ(第5ブロック) (学部)
診療参加型臨床実習Ⅱ(第6ブロック) (学部)
診療参加型臨床実習Ⅱ(第7ブロック) (学部)
診療参加型臨床実習Ⅱ(第8ブロック) (学部)
選択実習Ⅰ (学部)
選択実習Ⅱ (学部)
選択実習Ⅲ (学部)
重点セミナー(卒業試験解説講義) (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

赤池雅史 :
歯科医師のための医学ハンドブック「呼吸困難・息切れ・喘息」,
医歯薬出版株式会社, 2014年5月. 吉本勝彦, 赤池雅史, 苛原稔, 青田桂子 :
歯科医師のための医学ハンドブック,
医歯薬出版株式会社, 東京, 2014年5月. 赤池雅史, 松本俊夫 :
V 実験的研究 6．血管内皮障害―nitric oxideの観点から―,
株式会社金芳堂, 2010年10月.

論文

藤川理恵, 高開登茂子, 久米博子, 三木幸代, 原田路可, 加根千賀子, 赤池雅史, 楊河宏章, 苛原稔 :
モンゴル国 A 病院のモンゴル人看護師のリスク感性の分析,
日本看護学会誌 18(1): 13-20, 2023, Vol.18, No.1, 13-20, 2023年. 青木理紗, 高石和美, 西川美佳, 藤原茂樹, 長宗雅美, 赤池雅史, 河野文昭, 川人伸次 :
心肺蘇生教育に用いる気道管理シミュレータ4種類の気管挿管手技における比較,
日本歯科医学教育学会雑誌, Vol.38, No.1, 63-68, 2022年.

(キーワード): 気管挿管 / 気道管理 / シミュレータ / シミュレーション / 心肺蘇生
(出版サイトへのリンク): ● Publication site (DOI): 10.24744/jdea.38.1_63
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390573407641146752; ● Search Scopus @ Elsevier (DOI): 10.24744/jdea.38.1_63

(DOI: 10.24744/jdea.38.1_63, CiNii: 1390573407641146752) Y Hoshina, Keigo Yada, H Maki, T Yoshino, H Takaiso and Masashi Akaike :
Medical English Education in Japan: Developing a Curriculum to Motivate Students by Providing Visualizing Opportunities Using Near-peer Teaching,
The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 332-334, 2022.

(要約): Despite advancements in the pedagogy of medical education in various fields, Japan has no standardized medical English education. The U.S. Medical Licensing Examination (USMLE) Study Group of Tokushima is an extracurricular activity in which medical students and recent graduates meet every 1-2 months. The aim is to stimulate students' curiosity ; cultivate their initiative, self-efficacy, and English learning goals ; and motivate them to be self-regulated learners. Accordingly, we conducted near-peer teaching style lectures that focused on sharing medical English-related experiences, so students could have regular opportunities to visualize the benefits of learning medical English. Following the activities, we observed increased motivation and self-study among students, resulting in a high USMLE passing rate. Furthermore, five members started their training at American hospitals and pursued careers in English-speaking environments. Thus, near-peer teaching style leads to shared medical English-related experiences that help students to visualize English-related opportunities. This education style taught by similar generations aids in setting a specific goal by providing access to role models, cultivating their initiative and self-efficacy, motivating them to learn English, and producing positive outcomes.Modifying the curriculum to actively create opportunities for students to visualize themselves in an international environment can motivate them to continue learning English. J. Med. Invest. 69 : 332-334, August, 2022.
(キーワード): Curriculum / Education, Medical / Humans / Japan / Learning / Students, Medical / Teaching
(徳島大学機関リポジトリ): ● Metadata: 117767
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.332
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244792; ● CiNii @ 国立情報学研究所 (CRID): 1390293788341785728; ● Search Scopus @ Elsevier (PMID): 36244792; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.332

(徳島大学機関リポジトリ: 117767, DOI: 10.2152/jmi.69.332, PubMed: 36244792, CiNii: 1390293788341785728) Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 189-191, 2021.

(要約): The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116019
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.189
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994469; ● Search Scopus @ Elsevier (PMID): 33994469; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.189

(徳島大学機関リポジトリ: 116019, DOI: 10.2152/jmi.68.189, PubMed: 33994469) 吉田光輝, 丹黒章, 東野恒作, 近藤和也, 岩田貴, 赤池雅史, 金山博臣, 鶴尾吉宏 :
【最先端医療を支える解剖学】呼吸器外科における最先端手術手技とCAL(Clinical Anatomy Laboratory),
四国医学雑誌, Vol.76, No.5-6, 225-234, 2020年.

(要約): Recently, endoscopic surgery is the most common procedurein the field of thoracic surgery. The newestthoracic surgeryapproaches are the video-assisted thoracic surgery(VATS), the one-port video-assisted thoracic surgery, and the robotic surgery. The individual advantages and disadvantages of these procedures have been discussed. VATS covers a field of view of the surgical field from the leg to the head. The basic method in performing VATS is that the surgeon operates on the abdominal area of the patient and the assistant expands the surgical field from the patient's back. It is currently the standard surgical procedure. The advantage of one-port VATS is the one port itself and its cosmetic advantages and pain reduction. The advantage of robotic surgery is that it has a clear three-dimensional enlarged field of view and can be performed using the delicate moving robotic arm. However, a good surgical training system should be established for the familiarization of these procedures. The clinical anatomy laboratory is the most efficient surgical training in addition to dry and wet lab training. Our institution has fresh-frozen cadavers, which are rare in Japan. The participating thoracic surgeons underwent training for VATS lobectomy, subxiphoid extended thymectomy, and pleurectomy decortication. This training is beneficial for educational and clinical purposes. In the future, we must obtain consistent surgical education before and after graduation using fresh-frozen cadavers. At the same time, a good organ model for training is also necessary. The surgeon has to cooperate with anatomy doctors for the development of a good surgical organ model. For the development of future surgical medicine, surgical training programs should be implemented.
(キーワード): thoracic surgery / fresh frozen cadaver / surgical training
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050005888447565312

(CiNii: 1050005888447565312) 植野美彦, 関陽介, 赤池雅史, 野間口雅子 :
教育連動型AO入試の設計と実施ーー地方国立大学における研究医の養成・確保をめざしてーー,
大学入試研究ジャーナル, No.30, 207-213, 2020年.

(キーワード): 教育連動型AO入試 / 研究医 / 四国 / アドミッション・ポリシー / 採点方法のルール
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522543655921123712

(CiNii: 1522543655921123712) 坪井光弘, 青山万理子, 滝沢宏光, 吉田光輝, 岩田貴, 赤池雅史, 金山博臣, 鶴尾吉宏, 丹黒章 :
内視鏡手術の教育システム,
日本内分泌・甲状腺外科学会雑誌, Vol.37, No.1, 22-26, 2020年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11226/jaesjsts.37.1_22
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390848250117531136; ● Search Scopus @ Elsevier (DOI): 10.11226/jaesjsts.37.1_22

(DOI: 10.11226/jaesjsts.37.1_22, CiNii: 1390848250117531136) Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome,
Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019.

(要約): It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR.
(キーワード): Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / 女性 (female) / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / 男性 (male) / Prognosis / Retrospective Studies / Risk Factors / Stents
(徳島大学機関リポジトリ): ● Metadata: 113220
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.44735
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329; ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735

(徳島大学機関リポジトリ: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus) Shusuke Yagi, Robert Zheng, Seiichi Nishiyama, Yutaka Kawabata, Takayuki Ise, Kosuke Sugiura, Haruhiko Yoshinari, Toshihiko Nishisho, Yoshimi Bando, Kumiko Kagawa, Daiju Fukuda, Tomohiro Soga, Yoshihito Saijoh, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinji Kawahito, Masashi Akaike and Masataka Sata :
Osteolytic primary bone lymphoma in the multiple bones,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 347-350, 2019.

(要約): Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling. J. Med. Invest. 66 : 347-350, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114167
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.347
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656303; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074142443

(徳島大学機関リポジトリ: 114167, DOI: 10.2152/jmi.66.347, PubMed: 31656303, Elsevier: Scopus) Shusuke Yagi, Rie Ueno, Kumiko Sutou, Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshihito Saijo, Tomoya Hara, Takayuki Ise, Kenya Kusunose, Mika Bando, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Daiju Fukuda, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Lambda-like J wave due to acute myocardial infarction of the diagonal branch,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 185-187, 2019.

(要約): The culprit lesion of acute myocardial infarction could be predicted by electrocardiogram findings. However, we experienced some cases with coronary angiographic finding in the area of ST-T elevation that was different from that predicted. The lambda-like J wave could be caused by ischemia although the mechanism has not been fully elucidated. We report a case of acute myocardial infarction that showed discrepancy between ST-T elevation with lambda-like ischemic J wave in a broad area and coronary angiographical finding of diagonal branch occlusion. J. Med. Invest. 66 : 185-187, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113420
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.185
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064936; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065772885

(徳島大学機関リポジトリ: 113420, DOI: 10.2152/jmi.66.185, PubMed: 31064936, Elsevier: Scopus) K Adachi, S Hashiguchi, M Saito, S Kashiwagi, T Miyazaki, H Kawai, Hirotsugu Yamada, T Iwase, Masashi Akaike, Shoichiro Takao, M Kobayashi, M Ishizaki, T Matsumura, M Mori-Yoshimura and E Kimura :
Detection and management of cardiomyopathy in female dystrophinopathy carriers,
Journal of the Neurological Sciences, Vol.386, 74-80, 2018.

(要約): Regular health checkups for mothers of patients with Duchenne muscular dystrophy have been performed at National Hospital Organization Tokushima Hospital since 1994. Among 43 mothers participated in this study, 28 dystrophinopathy carriers were identified. Skeletal and cardiac muscle functions of these subjects were examined. High serum creatine kinase was found in 23 subjects (82.1%). Obvious muscle weakness was present in 5 (17.8%) and had progressed from 1994 to 2015. Cardiomyopathy was observed in 15 subjects (60.0%), including dilated cardiomyopathy-like damage that was more common in the left ventricular (LV) posterior wall. Late gadolinium enhancement on cardiac MRI was found in 5 of 6 subjects, suggesting fibrotic cardiac muscle. In speckle tracking echocardiography performed seven years later, global longitudinal strain was decreased in these subjects, indicating LV myocardial contractile abnormality. These results suggest that female dystrophinopathy carriers should receive regular checkups for detection and treatment of cardiomyopathy, even if they have no cardiac symptoms.
(キーワード): Adult / Cardiomyopathies / Contrast Media / Creatine Kinase / Disease Management / Dystrophin / Electrocardiography / Female / Gadolinium / Humans / Image Processing, Computer-Assisted / Middle Aged / Muscle, Skeletal / Mutation / Natriuretic Peptide, Brain / Neuroimaging / Neurologic Examination / Retrospective Studies
(徳島大学機関リポジトリ): ● Metadata: 115572
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jns.2017.12.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29358000; ● Search Scopus @ Elsevier (PMID): 29358000; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2017.12.024

(徳島大学機関リポジトリ: 115572, DOI: 10.1016/j.jns.2017.12.024, PubMed: 29358000) T Miyamoto, A Akaishi, T Takagai, K Kida, Masashi Akaike and Hiroaki Yanagawa :
Implementation of clinical research coordinator hospital certification course to spread understanding of clinical trials,
Japanese Journal of Clinical Pharmacology and Therapeutics, Vol.49, No.1, 7-11, 2018.

(徳島大学機関リポジトリ): ● Metadata: 111285
(出版サイトへのリンク): ● Publication site (DOI): 10.3999/jscpt.49.7
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85042626614

(徳島大学機関リポジトリ: 111285, DOI: 10.3999/jscpt.49.7, Elsevier: Scopus) Hiromu Yamazaki, Shusuke Yagi, Yuta Torii, Rie Amano, Yasuyuki Oomichi, Teruaki Sangawa, Daiju Fukuda, Muneyuki Kadota, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels,
Journal of Cardiology, Vol.71, No.3, 305-309, 2017.

(要約): It is well known that warfarin inhibits the synthesis of vitamin K-dependent anticoagulants, including thrombin, protein C and S, and factor Xa, leading, paradoxically, to an initial hypercoagulable state. Edoxaban, a direct inhibitor of activated factor X is widely used for the treatment of acute venous thromboembolism (VTE). However, the effect of edoxaban on circulating coagulation factors, in patients with acute VTE, remains unknown. We enrolled 57 patients with acute VTE with/without pulmonary embolism treated with edoxaban (n=37) or warfarin (n=20) in a clinical setting. Before treatment and 2 weeks after treatment, we evaluated thrombotic burden using ultrasound or computed tomography angiography. We also evaluated thrombin generation, represented by prothrombin fragment F1+2; thrombus degradation, represented by D-dimer; and levels of anticoagulants, including protein C, protein S, and antithrombin III. Both edoxaban and warfarin treatment improved thrombotic burden and decreased prothrombin fragment F1+2, and D-dimer. Edoxaban treatment preserved protein C and protein S levels. In contrast, warfarin decreased protein C and protein S levels. Neither treatment affected antithrombin III. Edoxaban improves VTE while preserving protein C and protein S levels, thereby indicating that edoxaban improves thrombotic burden while maintaining levels of anticoagulants.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2017.09.009
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29100817; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032912457

(DOI: 10.1016/j.jjcc.2017.09.009, PubMed: 29100817, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Takeshi Kondo, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Daiju Fukuda, Yutaka Nakaya, Kin-Ichiro Suwaki, Takashi Takeji, Toshihiro Wada, Masdan Hotimah Salim, Saori Hama, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Munehide Matsuhisa, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus.,
Advances in Therapy, Vol.35, No.1, 124-134, 2017.

(要約): Predictors for the effect of sodium glucose co-transporter 2 (SGLT2) inhibitors at lowering hemoglobin A1c (HbA1c) levels in type 2 diabetes mellitus patients remain unclear. We therefore aimed to elucidate these predictors in type 2 diabetes patients after 3 months of SGLT2 treatment. A total of 302 consecutive type 2 diabetes patients who had been treated with SGLT2 inhibitors as monotherapy or add-on therapy to existing antidiabetic treatments were enrolled retrospectively. After excluding 27 patients whose HbA1c levels could not be evaluated 3 months after treatment, the glucose-lowering effects of SGLT2 inhibitors were assessed in 275 patients by measuring HbA1c levels before and 3 months after treatment. The predictors for changes in HbA1c levels after 3 months of treatment were evaluated. SGLT2 inhibitor treatment for 3 months decreased HbA1c levels from 7.8 ± 1.2% to 7.4 ± 1.0% (p < 0.0001). A multiple regression analysis showed that the independent determinants for SGLT2 inhibitor treatment effect included decreased HbA1c levels after 1 month of treatment, high baseline HbA1c levels, and a high estimated glomerular filtration rate (eGFR). We show that type 2 diabetes patients who received the greatest glucose-lowering effect with SGLT2 inhibitor treatment were those with preserved renal function (high baseline eGFR) and high baseline HbA1c levels. Moreover, SGLT2 inhibitor treatment efficacy could be predicted by the patients' initial response to treatment.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12325-017-0639-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29185199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85035102977

(DOI: 10.1007/s12325-017-0639-z, PubMed: 29185199, Elsevier: Scopus) Shusuke Yagi, Takeshi Soeki, Ken-Ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome,
International Heart Journal, Vol.58, No.5, 720-723, 2017.

(要約): The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.
(キーワード): Adult / Aged / Aged, 80 and over / Biomarkers / Brugada Syndrome / Chromatography, Gas / Docosahexaenoic Acids / Eicosapentaenoic Acid / Electrocardiography / Follow-Up Studies / Humans / Incidence / 日本 (Japan) / Male / Middle Aged / Prevalence / ROC Curve / Retrospective Studies / Risk Assessment / Risk Factors / Syncope / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-278
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966307; ● CiNii @ 国立情報学研究所 (CRID): 1390282680202467328; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032215381

(DOI: 10.1536/ihj.16-278, PubMed: 28966307, CiNii: 1390282680202467328, Elsevier: Scopus) Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Koji Nishikawa, Daiju Fukuda, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Shinsuke Katoh, Ken-ichi Aihara, Masashi Akaike and Masataka Sata :
Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.,
International Heart Journal, Vol.58, No.5, 746-751, 2017.

(要約): Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.
(キーワード): Body Composition / Cardiac Rehabilitation / Exercise Tolerance / Female / Follow-Up Studies / 心不全 (heart failure) / Humans / Intra-Abdominal Fat / Male / Middle Aged / 肥満症 (obesity) / 酸素消費 (oxygen consumption) / Prognosis / Retrospective Studies / Weight Loss
(徳島大学機関リポジトリ): ● Metadata: 110111
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-454
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28966316; ● Summary page in Scopus @ Elsevier: 2-s2.0-85032221042

(徳島大学機関リポジトリ: 110111, DOI: 10.1536/ihj.16-454, PubMed: 28966316, Elsevier: Scopus) Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Salim Masdan Hotimah, G Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Michio Shimabukuro and Masataka Sata :
Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus.,
Diabetology & Metabolic Syndrome, Vol.9, 78, 2017.

(要約): It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 ± 0.5% to 6.7 ± 0.6% (P < 0.05) and decreased EAT thickness from 9.3 ± 2.5 to 7.3 ± 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).
(徳島大学機関リポジトリ): ● Metadata: 114544
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13098-017-0275-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29034006; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030465923

(徳島大学機関リポジトリ: 114544, DOI: 10.1186/s13098-017-0275-4, PubMed: 29034006, Elsevier: Scopus) Shusuke Yagi, Daiju Fukuda, KI Aihara, Masashi Akaike, Michio Shimabukuro and Masataka Sata :
n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease.,
Journal of Atherosclerosis and Thrombosis, Vol.24, No.10, 999-1010, 2017.

(要約): The adoption of the Western-style diet, with decreased fish intake and lack of exercise, has increased the prevalence of cardiovascular disease (CVD) in Japan. Statin treatment has been established to reduce the risk of cardiovascular events; however, 60%-70% of these events occur despite its use. Thus, the residual risk for CVD should be identified and resolved to reduce further cardiovascular events. The serum levels of n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid and docosahexaenoic acid, are reportedly associated with an increased incidence of cardiovascular events and mortality, whereas the addition of n-3 PUFA treatment to the statin treatment decreases cardiovascular events. Similar to statins, n-3 PUFAs have pleiotropic effects in addition to lipid-modifying effects. Pre-clinical and clinical studies have shown that n-3 PUFAs prevent cardiovascular events by ameliorating endothelial function and attenuating lipid accumulation, vascular inflammation, and macrophage recruitment, thereby causing coronary plaque development and rupture. Taken together, n-3 PUFAs are comprehensively able to attenuate the atherogenic response. Therefore, n-3 PUFA intake is recommended to prevent cardiovascular events, particularly in patients with multiple cardiovascular risk factors.
(徳島大学機関リポジトリ): ● Metadata: 115484
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.RV17013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28835582; ● Summary page in Scopus @ Elsevier: 2-s2.0-85030703516

(徳島大学機関リポジトリ: 115484, DOI: 10.5551/jat.RV17013, PubMed: 28835582, Elsevier: Scopus) Shusuke Yagi, Minoru Mitsugi, Teruaki Sanagawa, Masashi Akaike and Masataka Sata :
Paget-Schroetter Syndrome in a Baseball Pitcher.,
International Heart Journal, Vol.58, No.4, 637-640, 2017.

(要約): Paget-Schroetter syndrome (PSS) is thrombosis of the deep veins draining the upper extremity due to anatomic abnormalities of the thoracic outlet that cause subclavian compression and subsequent thrombosis, leading to thrombus formation in the subclavian vein. Vigorous arm activity in sports is a known risk factor. Here, we report a case of Paget-Schroetter syndrome in a 31-year-old male non-professional baseball pitcher.
(キーワード): Adult / Baseball / Fibrinolytic Agents / Humans / Male / Thrombolytic Therapy / Tomography, X-Ray Computed / Upper Extremity Deep Vein Thrombosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.16-447
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28701678; ● Summary page in Scopus @ Elsevier: 2-s2.0-85026825932

(DOI: 10.1536/ihj.16-447, PubMed: 28701678, Elsevier: Scopus) Takeshi Mitsuhashi, Ryoko Uemoto, Kazue Ishikawa, Sumiko Yoshida, Yasumasa Ikeda, Shusuke Yagi, Toshio Matsumoto, Masashi Akaike and Ken-ichi Aihara :
Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.,
Journal of Atherosclerosis and Thrombosis, 2017.

(要約): In Study 1, pitavastatin attenuated plaque formation and medial fibrosis of the aortic root with decreased macrophage infiltration in eNOS(-/-) ApoE(-/-) mice. PCR array analysis showed reductions in aortic gene expression of proatherogenic factors, including Ccl2 and Ccr2 in pitavastatin-treated double mutant mice. In addition, pitavastatin activated not only atherogenic p38MAPK and JNK but also anti-atherogenic ERK1/2 and ERK5 in the aorta of the double mutant mice. In Study 2, pitavastatin prolonged hind-limb survival after the surgery with increased BCL2-to-BAX protein ratio and inactivated JNK. Enhanced expression of anti-apoptotic genes, including Vegf, Api5, Atf5, Prdx2, and Dad1, was observed in the ischemic limb of pitavastatin-treated eNOS(-/-) mice. Furthermore, pitavastatin activated both aortic and skeletal muscle AMPK in the eNOS-deficient vascular injury models.
(徳島大学機関リポジトリ): ● Metadata: 115483
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.37747
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28592707; ● Search Scopus @ Elsevier (PMID): 28592707; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.37747

(徳島大学機関リポジトリ: 115483, DOI: 10.5551/jat.37747, PubMed: 28592707) M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ueno, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, Tomomi Matsuura, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Response prediction and influence of tolvaptan in chronic heart failure patients considering the interaction of the renin-angiotensin-aldosterone system and arginine vasopressin.,
International Heart Journal, Vol.57, No.4, 461-465, 2016.

(要約): The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS and exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis and improves volume overload in heart failure patients, however, the predictors of tolvaptan effectiveness and the influence on the RAAS and renal function according to tolvaptan therapy are not established. We evaluated 26 chronic heart failure patients receiving therapy with 15 mg/day tolvaptan and examined their laboratory and urinary data before and after tolvaptan therapy. A response to tolvaptan was defined as a body weight decrease by more than 2 kg in a week and a urine volume increase by 500 mL/ day compared with that before tolvaptan administration. Body weight, urine volume, and brain natriuretic peptide levels significantly improved (P < 0.05), without any worsening of renal function represented by serum creatinine, sodium, and potassium. Moreover, no significant changes were observed in the plasma renin activity and plasma aldosterone concentration (PAC). In the responder group, urine osmolality before tolvaptan administration was significantly higher (P < 0.05) but declined significantly after tolvaptan administration (P < 0.05). The AVP/PAC ratio before administration was positively correlated with the efficacy of tolvaptan. Tolvaptan treatment could prevent RAAS activation in chronic heart failure patients. Moreover, monitoring the AVP/PAC ratio may be useful in predicting the tolvaptan response.
(キーワード): Adult / Aged / Aged, 80 and over / Antidiuretic Hormone Receptor Antagonists / Arginine Vasopressin / Benzazepines / Body Mass Index / Female / Heart Failure / Humans / Male / Middle Aged / Prospective Studies / Renin-Angiotensin System / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109694
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.15-491
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27357439; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979587993

(徳島大学機関リポジトリ: 109694, DOI: 10.1536/ihj.15-491, PubMed: 27357439, Elsevier: Scopus) T Shigekiyo, E Sekimoto, H Shibata, Shuji Ozaki, T Okumura, H Fujinaga, H Shibata, Ken-ichi Aihara and Masashi Akaike :
Factor VII Tokushima: the first case of factor VII Cys22Gly with the development of myocardial infarction in the proband receiving recombinant factor VIIa replacement therapy.,
Blood Coagulation & Fibrinolysis, Vol.26, No.8, 956-958, 2015.

(要約): An 81-year-old man was referred to our department because of suspected factor VII (FVII) deficiency. His FVII activity was under 1%, whereas the FVII activity levels of his son and granddaughter were 65 and 109%, respectively. The nucleotide at position 3886 of his FVII gene was homozygous for G. A single T to G substitution results in the replacement of wild-type Cys at residue 22 by Gly. His son was heterozygous for G and T at position 3886, whereas his granddaughter was homozygous for wild-type T. These results suggest that he was homozygous for FVII Cys22Gly. He underwent radiofrequency ablation (RFA) for hepatocellular carcinoma, receiving 20 μg/kg of recombinant FVIIa prior to RFA and 10 μg/kg of recombinant FVIIa twice after RFA. He showed no bleeding tendency; however, a myocardial infarction was diagnosed and percutaneous coronary intervention was performed.
(キーワード): Aged, 80 and over / Base Sequence / Blood Coagulation Tests / Coagulants / Factor VII Deficiency / Factor VIIa / Genotype / Heterozygote / Homozygote / Humans / Male / Molecular Sequence Data / Myocardial Infarction / Pedigree / Recombinant Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/MBC.0000000000000346
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26517065; ● Summary page in Scopus @ Elsevier: 2-s2.0-84947057797

(DOI: 10.1097/MBC.0000000000000346, PubMed: 26517065, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando, Tomoya Hara, Sachiko Nishimoto, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.,
Nutrition Journal, Vol.14, No.1, 111, 2015.

(要約): BACKGROUND: The hospitalization rate for acute coronary syndrome (ACS) for people aged 50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unknown whether reduced serum levels of n-3 PUFAs is also a risk factor for ACS in patients aged 50 years.METHODS AND RESULTS: We retrospectively reviewed 102 (male/ female 73/29) Japanese ACS patients whose serum levels of EPA/arachidonic acid (AA) and DHA/AA were evaluated on admission. The EPA/AA ratio was the lowest in patients aged 50 compared to patients aged 51-74 and 75. Pearson correlation analysis showed that early ACS onset was associated with low EPA/AA and DHA/AA ratios, and multiple regression analysis determined that decreased ratios of EPA/AA and DHA/AA, and male sex, current smoker status, increased body mass index and triglyceride levels, independently correlated with early ACS onset. Conversely, low-density and high-density lipoproteins, glycated hemoglobin, and hypertension did not correlate with early ACS onset. Subgroup analyses of male patients revealed that decreased ratios of EPA/AA and DHA/AA independently correlated with early ACS onset.CONCLUSION: Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12937-015-0102-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26514181; ● Summary page in Scopus @ Elsevier: 2-s2.0-84945959581

(DOI: 10.1186/s12937-015-0102-4, PubMed: 26514181, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Masashi Akaike, Daiju Fukuda, HM Salim, Masayoshi Ishida, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Toshio Matsumoto and Masataka Sata :
Predictive factors for efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus.,
Diabetes & Metabolism Journal, Vol.39, No.4, 342-347, 2015.

(要約): BACKGROUND: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment.METHODS: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3±35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively.RESULTS: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167±63 to 151±49 mg/dL (P<0.01), and from 7.5%±1.3% to 6.9%±0.9% (P<0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease.CONCLUSION: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.
(キーワード): Coronary artery disease / 糖尿病 (diabetes mellitus) / Dipeptidyl-peptidase IV inhibitors / Obese / Predictive factors
(出版サイトへのリンク): ● Publication site (DOI): 10.4093/dmj.2015.39.4.342
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26301197; ● Summary page in Scopus @ Elsevier: 2-s2.0-84939780057

(DOI: 10.4093/dmj.2015.39.4.342, PubMed: 26301197, Elsevier: Scopus) Tomoya Hara, Shusuke Yagi, Masashi Akaike and Masataka Sata :
Transdermal patch of bisoprolol for the treatment of hypertension complicated with aortic dissection.,
International Journal of Cardiology, Vol.198, 220-221, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2015.06.112
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26173061; ● Summary page in Scopus @ Elsevier: 2-s2.0-84940416779

(DOI: 10.1016/j.ijcard.2015.06.112, PubMed: 26173061, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, Akira Takashima, Tomoya Hara, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.,
Journal of Atherosclerosis and Thrombosis, Vol.22, No.5, 447-454, 2015.

(要約): AIM: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.METHODS: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).RESULTS: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P0.01) and age was a negative (P0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.CONCLUSIONS: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
(キーワード): Flow-mediated dilation / n-3 polyunsaturated fatty acids / Docosahexaenoic acid
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.26914
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25342567; ● CiNii @ 国立情報学研究所 (CRID): 1390282679408260352; ● Summary page in Scopus @ Elsevier: 2-s2.0-84929412906

(DOI: 10.5551/jat.26914, PubMed: 25342567, CiNii: 1390282679408260352, Elsevier: Scopus) S Kimura, Yuka Ueda, Takayuki Ise, Shusuke Yagi, Takashi Iwase, K Nishikawa, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike, Natsuo Yasui and Masataka Sata :
Impact of supervised cardiac rehabilitation on urinary albumin excretion in patients with cardiovascular disease.,
International Heart Journal, Vol.56, No.1, 105-109, 2015.

(要約): Urinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m(2) who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m(2) to 67 ± 17 mL/minute/1.73 m(2), P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients.
(キーワード): Cardiac rehabilitation / Renal function / Cardiovascular disease
(徳島大学機関リポジトリ): ● Metadata: 109367
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.14-161
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25742947; ● Search Scopus @ Elsevier (PMID): 25742947; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.14-161

(徳島大学機関リポジトリ: 109367, DOI: 10.1536/ihj.14-161, PubMed: 25742947) Shusuke Yagi, A Takashima, M Mitsugi, T Wada, Junko Hotsuchi, Ken-ichi Aihara, T Hara, Masayoshi Ishida, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.,
Therapeutics and Clinical Risk Management, Vol.11, 83-88, 2015.

(要約): Background: Hypertension is one of the major risk factors for cardiovascular and cerebrovascular disease and mortality. Patients who receive insufficient doses of antihypertensive agents or who are poorly adherent to multidrug treatment regimens often fail to achieve adequate blood pressure (BP) control. The aim of this study was to determine the efficacy of an angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) combination tablet containing a regular dose of irbesartan (100 mg) and a high dose of amlodipine (10 mg) with regard to lowering BP and other risk factors for cardiovascular disease.Methods: We retrospectively evaluated data from 68 patients with essential hypertension whose treatment regimen was changed either from combination treatment with an independent ARB and a low-dose or regular-dose CCB or from a combination tablet of ARB and a low-dose or regular-dose CCB to a combination tablet containing amlodipine 10 mg and irbesartan 100 mg, because of incomplete BP control. Previous treatments did not include irbesartan as the ARB.Results: The combination tablet decreased systolic and diastolic BP. In addition, it significantly decreased serum uric acid, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels, independent of the BP-lowering effect. Treatment with the combination tablet did not affect serum triglycerides, plasma glucose, glycated hemoglobin, serum potassium or creatinine levels, or the urinary albumin excretion rate.Conclusion: The combination tablet containing amlodipine 10 mg and irbesartan 100 mg had a greater BP-lowering effect than an ARB and a low-dose or regular-dose CCB. In addition, the combination tablet had more favorable effects on serum uric acid, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels in patients with hypertension.
(キーワード): blood pressure / combination tablet / uric acid / low-density lipoprotein cholesterol / high-density lipoprotein cholesterol
(出版サイトへのリンク): ● Publication site (DOI): 10.2147/TCRM.S72299
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25624765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921260560

(DOI: 10.2147/TCRM.S72299, PubMed: 25624765, Elsevier: Scopus) Shusuke Yagi, T Hara, R Ueno, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Junko Hotsuchi, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.,
Nutrition Journal, Vol.13, No.1, 112, 2014.

(要約): BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD.METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated.RESULTS: Pearson correlation analysis showed that EPA (R =0.25, P <0.01), EPA/AA ratio (R =0.22, P =0.01), and left ventricular ejection fraction (R =0.15, P =0.04) were positively associated with MMSE score, and that age (R = -0.20, P <0.01) and brain natriuretic peptide levels (R = -0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded.CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients.
(キーワード): Aged / Arachidonic Acid / Cognition / Cognition Disorders / Coronary Disease / Eicosapentaenoic Acid / Fatty Acids, Omega-3 / Female / Humans / Japan / Male / Middle Aged / Retrospective Studies / Risk Factors / Stroke Volume
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1475-2891-13-112
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25471307; ● Summary page in Scopus @ Elsevier: 2-s2.0-84926465688

(DOI: 10.1186/1475-2891-13-112, PubMed: 25471307, Elsevier: Scopus) A Takashima, Takayuki Ise, Shusuke Yagi, Takashi Iwase, S Kimura, Yuka Ueda, K Nishikawa, A Ishii, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike and Masataka Sata :
Cardiac rehabilitation reduces serum levels of oxidized low-density lipoprotein.,
Circulation Journal, Vol.78, No.11, 2682-2687, 2014.

(要約): BACKGROUND: Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.MethodsandResults:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (VO2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak VO2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. VO2(peak VO2after CR-peak VO2before CR) was negatively associated with MDA-LDL (MDA-LDL after CR-MDA-LDL before CR) (R(2)=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.CONCLUSIONS: CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682-2687).
(キーワード): Cardiac rehabilitation / Lipoproteins / Oxidative stress
(徳島大学機関リポジトリ): ● Metadata: 109368
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-14-0532
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25241889; ● Search Scopus @ Elsevier (PMID): 25241889; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-14-0532

(徳島大学機関リポジトリ: 109368, DOI: 10.1253/circj.CJ-14-0532, PubMed: 25241889) Nhat-Tu Le, Yuichiro Takei, Yuki Izawa-Ishizawa, Kyung-Sun Heo, Hakjoo Lee, V Alan Smrcka, L Benjamin Miller, Ae Kyung Ko, Sara Ture, Craig Morrell, Keigi Fujiwara, Masashi Akaike and Jun-Ichi Abe :
Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents.,
The Journal of Immunology, Vol.193, No.7, 3803-3815, 2014.

(要約): Because ERK5 inhibits endothelial inflammation and dysfunction, activating ERK5 might be a novel approach to protecting vascular endothelial cells (ECs) against various pathological conditions of the blood vessel. We have identified small molecules that protect ECs via ERK5 activation and determined their contribution to preventing cardiac allograft rejection. Using high-throughput screening, we identified certain statins and antimalarial agents including chloroquine, hydroxychloroquine, and quinacrine as strong ERK5 activators. Pitavastatin enhanced ERK5 transcriptional activity and Kruppel-like factor-2 expression in cultured human and bovine ECs, but these effects were abolished by the depletion of ERK5. Chloroquine and hydroxychloroquine upregulated ERK5 kinase activity and inhibited VCAM-1 expression in an ERK5-dependent but MAPK/ERK kinase 5- and Kruppel-like factor 2/4-independent manner. Leukocyte rolling and vascular reactivity were used to evaluate endothelial function in vivo, and we found that EC-specific ERK5 knockout (ERK5-EKO) mice exhibited increased leukocyte rolling and impaired vascular reactivity, which could not be corrected by pitavastatin. The role of endothelial ERK5 in acute cardiac allograft rejection was also examined by heterotopic grafting of the heart obtained from either wild-type or ERK5-EKO mice into allomismatched recipient mice. A robust increase in both inflammatory gene expression and CD45-positive cell infiltration into the graft was observed. These tissue rejection responses were inhibited by pitavastatin in wild-type but not ERK5-EKO hearts. Our study has identified statins and antimalarial drugs as strong ERK5 activators and shown that ERK5 activation is preventive of endothelial inflammation and dysfunction and acute allograft rejection.
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/jimmunol.1400571
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25187658; ● Search Scopus @ Elsevier (PMID): 25187658; ● Search Scopus @ Elsevier (DOI): 10.4049/jimmunol.1400571

(DOI: 10.4049/jimmunol.1400571, PubMed: 25187658) T Hara, K Kishi-Tanaka, Takashi Iwase, Hirotsugu Yamada, Masashi Akaike and Masataka Sata :
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report.,
The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 404-408, 2014.

(要約): A 70-year-old woman with dyspnea on exertion was admitted to our hospital. She had a history of apical hypertrophic cardiomyopathy (HCM) and repeated hospitalization for heart failure. Results of physical examination were normal except for leg edema. Echocardiography showed apical HCM with preserved LV systolic function (LVEF = 70%). Although dyspnea on exertion and leg edema improved rapidly with the use of diuretics, her symptoms soon worsened when daily activity was started again. In order to examine the effect of preload on hemodynamics, we performed a lower limb positive pressure test by compressing both legs using a household air leg massager. Echocardiography showed increases in mitral E velocity, E/A ratio and pulmonary venous D flow as well as decrease in stroke volume during the lower limb positive pressure test. Simultaneously-recorded pressure study also showed elevated LVEDP and increased v wave of pulmonary capillary wedge pressure. These results suggested that even a small increase in preload led to elevation of LVEDP and symptomatic worsening due to severe diastolic heart failure in the present case. The lower limb positive pressure test may be useful for assessing the effect of preload on hemodynamics in patients with diastolic heart failure.
(キーワード): diastolic heart failure / lower limb positive pressure test / apical hypertrophic cardiomyopathy
(徳島大学機関リポジトリ): ● Metadata: 109593
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.404
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264062; ● CiNii @ 国立情報学研究所 (CRID): 1390282679219954688; ● Summary page in Scopus @ Elsevier: 2-s2.0-84907518768

(徳島大学機関リポジトリ: 109593, DOI: 10.2152/jmi.61.404, PubMed: 25264062, CiNii: 1390282679219954688, Elsevier: Scopus) Shusuke Yagi, M Fujimura, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, M Tada, Yuka Ueda, Takayuki Ise, Koji Yamaguchi, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis.,
Journal of Cardiology Cases, Vol.10, No.2, 54-57, 2014.

(要約): Rates of morbidity and mortality from cardiovascular disease are high in patients with rheumatoid arthritis (RA); however, the mechanisms and biomarkers that reflect coronary plaque vulnerability have not yet been established. We present a case of acute coronary syndrome (ACS) presumably caused by exacerbation of chronic inflammation of RA, in which an abrupt increase in serum triglyceride was seen on the day of onset of ACS but not during effort angina. This case suggests that RA patients with an abrupt increase in triglyceride need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture.<Learning objective: Triglyceride might be a sensitive biomarker of activated macrophages and plaque vulnerability in patients with RA. RA patients with an abrupt increase in triglyceride might need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture.>
(キーワード): Acute coronary syndrome / Triglyceride / Tumor necrosis factor- / Biomarker
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.04.009
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84905378195

(DOI: 10.1016/j.jccase.2014.04.009, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Takeshi Kondo, Itsuro Endo, Junko Hotsuchi, Takayuki Ise, Takashi Iwase, Masashi Akaike, Toshio Matsumoto and Masataka Sata :
High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients.,
Endocrine Journal, Vol.61, No.7, 727-733, 2014.

(要約): Excess parathyroid hormone (PTH), known as primary hyperparathyroidism (pHPT), results in hypercalcemia and bone loss. Recent studies have shown that PTH is associated with the occurrence of hypertension in Western countries; however, controversy remains regarding high serum levels of PTH and calcium as risk factors for hypertension in Japanese patients. We retrospectively enrolled 114 consecutive Japanese patients who visited our hospital for examination and treatment of hypercalcemia and/or hypertension with serum calcium levels ≥ 9.8 mg/dL. To estimate the prevalence of hypertension, the patients were categorized according to calcium levels into hypercalcemic (10.2-13.4 mg/dL) and normocalcemic (9.8-10.1 mg/dL) groups, which were further categorized into high PTH (50-440 pg/mL) and low PTH (8-49 pg/mL) groups. The prevalence of hypertension was higher in patients with hypercalcemia than in patients with normocalcemia in both the high and low PTH groups. The prevalence of hypertension was higher in patients with high serum PTH levels than in patients with low serum PTH levels in both the hypercalcemic and normocalcemic groups. Logistic multiple regression analysis determined that serum calcium (P < 0.05) and PTH (P < 0.01) levels were positive contributors to hypertension. In conclusion, high serum levels of PTH and calcium are risk factors for hypertension in Japanese patients.
(キーワード): parathyroid hormone / カルシウム (calcium) / 高血圧 (hypertension)
(出版サイトへのリンク): ● Publication site (DOI): 10.1507/endocrj.EJ14-0004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24849536; ● CiNii @ 国立情報学研究所 (CRID): 1390001206300211712; ● Summary page in Scopus @ Elsevier: 2-s2.0-84905190698

(DOI: 10.1507/endocrj.EJ14-0004, PubMed: 24849536, CiNii: 1390001206300211712, Elsevier: Scopus) Masashi Akaike, Ken-ichi Aihara, Hiroaki Yanagawa, Takashi Iwase, Sumiko Yoshida, Sato Chiho, Saijo Tomoka, Hiroaki Mikasa, Kashiwada Yoshizaki, Yoshihisa Takaishi, Koichiro Tsuchiya, Toshiaki Tamaki, Toshio Matsumoto and Masataka Sata :
Efficacy and safety of Citrus sudachi peel in obese adults:A randomized, double-blind, pilot study,
Functional Foods in Health and Disease, Vol.4, No.6, 276-284, 2014.

(出版サイトへのリンク): ● Publication site (DOI): 10.31989/ffhd.v4i7.5
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85054855286

(DOI: 10.31989/ffhd.v4i7.5, Elsevier: Scopus) S Bando, Takeshi Soeki, T Matsuura, Toshiyuki Niki, Takayuki Ise, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, T Aiba, W Shimizu and Masataka Sata :
Congenital long QT syndrome with compound mutations in the KCNH2 gene.,
Heart and Vessels, Vol.29, No.4, 554-559, 2014.

(要約): Congenital long QT syndrome is a genetic disorder encompassing a family of mutations that can lead to aberrant ventricular electrical activity. We report on two brothers with long QT syndrome caused by compound mutations in the KCNH2 gene inherited from parents who had no prolonged QT interval on electrocardiography. The proband had syncope, and his elder brother suffered from ventricular fibrillation. Genetic testing revealed that both brothers had multiple mutations in the KCNH2 gene, including a missense mutation of C1474T (exon 6) as well as a frameshift/nonsense mutation, resulting from the insertion of 25 nucleotides, which caused an altered amino acid sequence beginning at codon 302 and a premature termination codon (i.e., TAG) at codon 339 (exon 4). Family genetic screening found that their father had the same frameshift mutation, and their mother and sister had the same missense mutation, in the KCNH2 gene. However, these other family members were asymptomatic, with normal QT intervals on electrocardiography. These results suggest that compound mutations in the KCNH2 gene inherited independently from the parents made the phenotypes of their sons more severe.
(キーワード): KCNH2 gene / Long QT syndrome / Compound mutation / Missense mutation / Frameshift mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0406-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24057343; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904036858

(DOI: 10.1007/s00380-013-0406-2, PubMed: 24057343, Elsevier: Scopus) 坂東智子, 赤池雅史, 鶴尾美穂, 石本寛子, 宮内和瑞, 坂東良美, 生島葉子, 宮恵子, 瀧雅, 原田和代, 角瀬裕子, 豊崎纏 :
徳島市医師会の女性医師支援事業,
四国医学雑誌, Vol.70, No.5-6, 161-166, 2014年.

(要約): In recent years, an increase in the ratio of female physicians in Tokushima Prefecture, with a particularly notable rise among younger generations that has exceeded the national average, has been observed. However, these physicians continue to face severe working environments, and support measures are required for female physicians during childbirth and in the early stages of parenthood. To this end, the Tokushima City Medical Association has been involved in initiatives to support female physicians since 2008. First, we developed ``Net Joy,'' a website that provides the information necessary for female physicians to continue their clinical work through a bulletin board system that offers information on topics such as employment and childcare. Furthermore, we have administered questionnaire surveys related to working environments and support systems in clinical training hospitals and compiled a booklet entitled Support Notebook for Female Physicians that is available on the Net Joy website. Since 2011, as post-residency training in ultrasound techniques, we have held six separate practical training seminars at the Tokushima University Hospital Ultrasound Examination Center and the Tokushima City Medical Association Hall. Since 2014, we have been involved in efforts to enhance its training content and develop it into a long-term program.
(キーワード): female physicians / website / practical training seminar
(徳島大学機関リポジトリ): ● Metadata: 109897
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812441738752

(徳島大学機関リポジトリ: 109897, CiNii: 1050282812441738752) Kyung-Sun Heo, J Hannah Cushman, Masashi Akaike, Chang-Hoon Woo, Xin Wang, Xing Qiu, Keigi Fujiwara and Jun-ichi Abe :
ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.,
Circulation, Vol.130, No.2, 180-191, 2014.

(要約): Our results demonstrate that ERK5, which is robustly activated by statins, is a hub molecule that upregulates macrophage efferocytosis, thereby suppressing atherosclerotic plaque formation. Molecules that upregulate ERK5 and its signaling in macrophages may be good drug targets for suppressing cardiovascular diseases.
(キーワード): Animals / Atherosclerosis / Cells, Cultured / Enzyme Activation / Macrophages / Mice / Mice, Inbred C57BL / Mice, Knockout / Mitogen-Activated Protein Kinase 7 / Phagocytosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.113.005991
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25001623; ● Search Scopus @ Elsevier (PMID): 25001623; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCULATIONAHA.113.005991

(DOI: 10.1161/CIRCULATIONAHA.113.005991, PubMed: 25001623) Takayuki Ise, Takashi Iwase, S Masuda, Shusuke Yagi, Masashi Akaike, S Nishio, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute pulmonary thromboembolism from deep vein thrombosis induced by trauma to the popliteal vein with a tennis racket.,
Journal of Cardiology Cases, Vol.9, No.4, 162-164, 2014.

(要約): Acute pulmonary thromboembolism (PTE) is mainly caused by deep vein thrombosis (DVT) and sometimes leads to a fatal outcome. Few cases of sport-related lower extremity DVT, involving direct external trauma, have been reported. A 58-year-old man, without any risk factors for thromboembolism suffered acute PTE from DVT after playing tennis. A detailed history revealed that he had hit his popliteal vein with each swing of his tennis racket and the site of the trauma, at popliteal fossa, was exactly the same as the site of the DVT formation. Therefore, the cause of DVT was suspected to be the repeated trauma to the popliteal vein. The repeated external trauma to the popliteal vein may have caused vascular endothelial damage, leading to DVT.
(キーワード): Acute pulmonary thromboembolism / Deep vein thrombosis / Trauma
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jccase.2014.01.001
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84897413698

(DOI: 10.1016/j.jccase.2014.01.001, Elsevier: Scopus) Shusuke Yagi, Kadota Muneyuki, Ken-ichi Aihara, Nishikawa Koji, Hara Tomoya, Takayuki Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Michio Shimabukuro, Shinsuke Katoh and Masataka Sata :
Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men,
Diabetology & Metabolic Syndrome, Vol.6, No.1, 27, 2014.

(要約): A high-calorie diet and physical inactivity, an imbalance between caloric intake and energy consumption, are major causes of metabolic syndrome (MetS), which manifests as accumulation of visceral fat and insulin resistance. However, the lifestyle-related factors associated with visceral fat mass in healthy men are not fully understood. We evaluated visceral fat area (VFA), skeletal muscle mass, caloric intake, and energy expenditure in 67 healthy male participants (mean age, 36.9 ± 8.8 years; body mass index 23.4 ± 2.5 kg/m2). Multiple regression analysis showed that the total skeletal muscle mass (P < 0.001) were negatively and age (P < 0.001) were positively associated with VFA. Lower limb muscle mass (P < 0.001) was strongly associated with VFA. However, total caloric intake, total energy expenditure, and energy expenditure during exercise were not associated with VFA. Skeletal muscle mass especially lower limb muscle mass negatively contributes to visceral fat mass in healthy men. Therefore, maintaining lower limb muscular fitness through daily activity may be a useful strategy for controlling visceral obesity and metabolic syndrome.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1758-5996-6-27
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24571923; ● Summary page in Scopus @ Elsevier: 2-s2.0-84896075201

(DOI: 10.1186/1758-5996-6-27, PubMed: 24571923, Elsevier: Scopus) Takeshi Soeki, Toshiyuki Niki, E. Uematsu, S. Bando, T. Matsuura, Kenya Kusunose, Takayuki Ise, Yuka Ueda, N. Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Daiju Fukuda, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Michio Shimabukuro, I. Kishimoto, Kenji Kangawa and Masataka Sata :
Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.,
Heart and Vessels, Vol.28, No.6, 795-801, 2013.

(要約): Vagal nerve stimulation has been postulated to confer an antifibrillatory effect. We studied whether ghrelin administration would exert an antiarrhythmic effect via modulation of autonomic nerve activity in rats after acute myocardial ischemia (MI). Male Sprague-Dawley rats were exposed to 30 min of ischemia following ligation of the left coronary artery. Animals were then randomized to receive either ghrelin (n = 26) or saline (n = 26) during the period of coronary ligation. Power spectral analysis of heart-rate variability revealed that the administration of ghrelin increased the high-frequency (HF) power and decreased the low-frequency (LF)/HF ratio. Ventricular tachyarrhythmias were less frequent in rats after MI who received ghrelin in comparison with rats that received saline. Immunoblotting and immunohistochemistry revealed that rats given saline alone during MI exhibited a marked reduction in phosphorylated connexin-43 within the left ventricle, whereas those that received ghrelin displayed only minor reductions in comparison with sham-operated rats. These effects of ghrelin were diminished by the coadministration of atropine or the blockade of vagal afferents. These data demonstrate that the beneficial effect of ghrelin might be mediated by modulation of cardiac autonomic nerve activity.
(キーワード): Animals / Anti-Arrhythmia Agents / Atropine / Connexin 43 / Disease Models, Animal / Ghrelin / Heart Rate / Heart Ventricles / Male / Muscarinic Antagonists / Myocardial Ischemia / Phosphorylation / Rats / Rats, Sprague-Dawley / Tachycardia, Ventricular / Time Factors / Vagotomy / Vagus Nerve
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00380-013-0333-2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23494606; ● Search Scopus @ Elsevier (PMID): 23494606; ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-013-0333-2

(DOI: 10.1007/s00380-013-0333-2, PubMed: 23494606) Shusuke Yagi, Masashi Akaike, Takayuki Ise, Yuka Ueda, Takashi Iwase and Masataka Sata :
Renin-angiotensin-aldosterone system has a pivotal role in cognitive impairment.,
Hypertension Research, Vol.36, No.9, 753-758, 2013.

(要約): Because dementia is associated with both deterioration in the quality of life and poor prognosis, the prevention of cognitive impairment (CI) is a critical problem in public health promotion. Hypertension is a risk factor for the aggravation of CI, and the renin-angiotensin-aldosterone system (RAAS) is a key player in the increased incidence and development of hypertension. Therefore, the RAAS is considered to be a promoting factor for CI development. Conversely, recent studies have shown that lowering blood pressure with RAAS inhibitors decreases the incidence of CI, dementia and cardiovascular disease. Blood-brain barrier-penetrating RAAS inhibitors appear to have advantages in preventing cognitive decline because they can suppress the RAAS in the hippocampus, which has an important role in cognition. Thus, RAAS blockage is a notable strategy for preventing CI.
(キーワード): Angiotensin-Converting Enzyme Inhibitors / Cognition / Cognition Disorders / Humans / Hypertension / Renin-Angiotensin System / Risk Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2013.51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23698805; ● Summary page in Scopus @ Elsevier: 2-s2.0-84883885656

(DOI: 10.1038/hr.2013.51, PubMed: 23698805, Elsevier: Scopus) Sumiko Yoshida, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo-Ueda, Ryoko Uemoto, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yasuhiro Mouri, Matomo Sakari, Takahiro Matsumoto, Ken-ichi Takeyama, Masashi Akaike, Mitsuru Matsumoto, Masataka Sata, Kenneth Walsh, Shigeaki Kato and Toshio Matsumoto :
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.,
Circulation, Vol.128, No.1, 60-71, 2013.

(要約): These results document a physiological role of AR in sex-independent angiogenic potency and provide evidence of novel cross-talk between the androgen/AR signaling and VEGF/kinase insert domain protein receptor signaling pathways.
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/CIRCULATIONAHA.113.001533
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23723256; ● Search Scopus @ Elsevier (PMID): 23723256; ● Search Scopus @ Elsevier (DOI): 10.1161/CIRCULATIONAHA.113.001533

(DOI: 10.1161/CIRCULATIONAHA.113.001533, PubMed: 23723256) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Daiju Fukuda, Masayoshi Ishida, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro and Masataka Sata :
Pharmacology of Aldosterone and the Effects of Mineralocorticoid Receptor Blockade on Cardiovascular Systems.,
Acta Cardiologica Sinica, Vol.29, No.3, 201-207, 2013.

(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84878307366

(Elsevier: Scopus) Shuji Kato, Itsuro Endo, Mitsunori Fujimura, Rika Kuriwaka-Kido, Yuichi Fujinaka, Ken-ichi Aihara, Takashi Iwase, Daisuke Inoue, Masashi Akaike, Masahiro Abe and Toshio Matsumoto :
Serum carboxy-terminal telopeptide of type I collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients: A pilot study.,
Atherosclerosis, Vol.229, No.1, 182-185, 2013.

(要約): Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p < 0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients.
(徳島大学機関リポジトリ): ● Metadata: 105936
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2013.03.030
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23639859; ● Search Scopus @ Elsevier (PMID): 23639859; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2013.03.030

(徳島大学機関リポジトリ: 105936, DOI: 10.1016/j.atherosclerosis.2013.03.030, PubMed: 23639859) Takayuki Ise, K Fujioka, Takashi Iwase, J. Hotchi, Masashi Akaike and Masataka Sata :
Ulcer-like projection caused by a penetrating branch to the bronchial artery.,
Journal of the American College of Cardiology, Vol.61, No.8, e147-147, 2013.

(キーワード): Aged / Aorta, Thoracic / Back Pain / Bronchial Arteries / Female / Hematoma / Humans / Remission, Spontaneous / Rupture, Spontaneous / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2012.10.047
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23428223; ● Summary page in Scopus @ Elsevier: 2-s2.0-84874522803

(DOI: 10.1016/j.jacc.2012.10.047, PubMed: 23428223, Elsevier: Scopus) 高島啓, 伊勢孝之, 上田由佳, 岩瀬俊, 八木秀介, 前田香代子, 西川幸治, 小笠原梢, 坂東美佳, 坂東左知子, 冨田紀子, 仁木敏之, 發知淳子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
心臓リハビリテーション, Vol.18, No.1, 130-133, 2013年.

(キーワード): 酸化LDL / 心臓リハビリテーション / 心肺運動負荷試験
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010381154583040

(CiNii: 1520010381154583040) Yasumasa Ikeda, Ken-ichi Aihara, Sumiko Yoshida, Takashi Iwase, Soichiro Tajima, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Koichiro Tsuchiya, Masataka Sata, Masashi Akaike, Shigeaki Kato, Toshio Matsumoto and Toshiaki Tamaki :
Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway,
The Journal of Biological Chemistry, Vol.287, No.41, 34256-34263, 2012.

(要約): We previously clarified that heparin cofactor II (HCII), a serine proteinase inhibitor, exerts various protective actions on cardiovascular diseases in both experimental and clinical studies. In the present study, we aimed to clarify whether HCII participates in the regulation of angiogenesis. Male heterozygous HCII-deficient (HCII(+/-)) mice and male littermate wild-type (HCII(+/+)) mice at the age of 12-16 weeks were subjected to unilateral hindlimb ligation surgery. Laser speckle blood flow analysis showed that blood flow recovery in response to hindlimb ischemia was delayed in HCII(+/-) mice compared with that in HCII(+/+) mice. Capillary number, arteriole number, and endothelial nitric-oxide synthase (eNOS), AMP-activated protein kinase (AMPK), and liver kinase B1 (LKB1) phosphorylation in ischemic muscles were decreased in HCII(+/-) mice. Human purified HCII (h-HCII) administration almost restored blood flow recovery, capillary density, and arteriole number as well as phosphorylation levels of eNOS, AMPK, and LKB1 in ischemic muscles of HCII(+/-) mice. Although treatment with h-HCII increased phosphorylation levels of eNOS, AMPK, and LKB1 in human aortic endothelial cells (HAECs), the h-HCII-induced eNOS phosphorylation was abolished by compound C, an AMPK inhibitor, and by AMPK siRNA. In a similar fashion, tube formation, proliferation, and migration of HAECs were also promoted by h-HCII treatment and were abrogated by pretreatment with compound C. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK-eNOS signaling pathway. These findings suggest that HCII is a novel therapeutic target for treatment of patients with peripheral circulation insufficiency.
(キーワード): Heparin cofactor II (HCII) / vascular endothelial cells / 血管新生 (angiogenesis)
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M112.353532
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22904320; ● Search Scopus @ Elsevier (PMID): 22904320; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M112.353532

(DOI: 10.1074/jbc.M112.353532, PubMed: 22904320) 久岡白陽花, 上田由佳, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 髙田信二郎, 赤池雅史, 安井夏生, 佐田政隆 :
(若手優秀演題セッション)尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
心臓リハビリテーション, Vol.17, No.1, 159-161, 2012年. 吉田守美子, 粟飯原賢一, 上田由佳, 伊勢孝之, 池田康将, 倉橋清衛, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
ロスバスタチンによる脂質低下作用非依存的な形態的および機能的頸動脈硬化改善作用,
Progress in Medicine, Vol.32, No.2, 315-320, 2012年. Hirotsugu Kurobe, Ken-ichi Aihara, Higashida Mayuko, Hirata Yoichiro, Nishiya Masako, Matsuoka Yuki, Tamotsu Kanbara, Nakayama Taisuke, Hajime Kinoshita, Mikio Sugano, Eiki Fujimoto, Kurobe Ayako, Sugawara Noriko, Takashi Kitaichi, Masashi Akaike, Masataka Sata, Toshio Matsumoto and Tetsuya Kitagawa :
Ezetimibe monotherapy ameliorates vascular function in patients with hypercholesterolemia through decreasing oxidative stress.,
Journal of Atherosclerosis and Thrombosis, Vol.18, No.12, 1080-1089, 2011.

(要約): Ezetimibe, an inhibitor of cholesterol intestinal absorption, is a lipid lowering agent. However, anti-atherogenic effects of ezetimibe have not been fully elucidated. Therefore, the objective in this study was to clarify the vascular protective effects of ezetimibe in patients with hypercholesterolemia. Ezetimibe was administered to 20 patients with hypercholesterolemia (group E), and 20 age- and sex-matched patients with hypercholesterolemia were followed as controls (group C). Difference in metabolic profiles and cardiovascular surrogate markers before ezetimibe treatment and after 12 weeks of ezetimibe treatment were statistically evaluated. Ezetimibe treatment significantly reduced serum levels of low-density lipoprotein cholesterol (LDL-C) and malondialdehyde-modified low-density lipoprotein (MDA-LDL). In addition, the values of body mass index, body weight, waist circumference, plasma HbA1c and urinary albumin were significantly decreased in group E compared to those in group C. On the other hand, high-density lipoprotein cholesterol (HDL-C) and adiponectin levels were significantly increased in group E compared to those in group C. The values of brachial-ankle pulse wave velocity (ba-PWV), mean arterial blood pressure (m-ABP), and % of flow-mediated dilation (FMD) were significantly improved in group E. Furthermore, ultrasonic studies demonstrated amelioration of the vascular stiffness of common carotid arteries in group E but not in group C. These vascular protective effects of ezetimibe were statistically correlated with the decreased values of MDA-LDL and MDA-LDL-to-LDL-C ratio but not with those of LDL-C. Ezetimibe has a lipid lowering-independent vascular protective effect in patients with hypercholesterolemia through decreasing oxidative stress.
(キーワード): Aged / Azetidines / Case-Control Studies / Endothelium, Vascular / Humans / Hypercholesterolemia / Lipids / Male / Middle Aged / 酸化ストレス (oxidative stress)
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.9548
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22027560; ● Search Scopus @ Elsevier (PMID): 22027560; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.9548

(DOI: 10.5551/jat.9548, PubMed: 22027560) Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina.,
International Journal of Cardiology, Vol.153, No.3, 272-276, 2011.

(要約): Late stent thrombosis (LST) after sirolimus-eluting stent (SES) implantation has been demonstrated previously. Although incomplete neointimal coverage after SES implantation has been reported, local long-term hypercoagulability remains unknown. We evaluated the local persistent coagulative response in eighty-three consecutive patients with stable angina, treated with either SES (n=51) or BMS (n=32) implantation for isolated de novo left anterior descending (LAD) stenosis. We measured prothrombin fragment F1+2 (frF1+2) and D-dimer levels sampled in the coronary sinus (CS) and sinus of Valsalva (V). The transcardiac gradient (Δ) was defined as the CS level minus V level. The ΔfrF1 + 2 and ΔD-dimer were significantly greater in the SES group than in the BMS group (0.50 ± 0.35 vs -0.14 ± 0.15 nmol/l, p=0.009 and 0.24 ± 0.21 vs -0.05 ± 0.16 μg/ml, p=0.041, respectively). We selected the hypocoagulative [ΔfrF1 + 2<0.15 (mean value-SD) nmol/l, n=21] and hypercoagulative [ΔfrF1 + 2>0.85 (mean value+SD) nmol/l, n=14] groups out of the SES patients. Multivariate analysis was performed to identify independent predictors of local hypercoagulability. Total SES length was the only independent predictor of local hypercoagulability. There was a significant positive correlation between the ΔfrF1 + 2 and total stent length in the SES group (r=0.57, p<0.05). An increased local coagulative response was observed in the convalescent phase after SES implantation as compared to BMS. Careful long-term follow-up of patients after longer SES implantation is recommended in order to avoid LST.
(キーワード): Aged / Angina, Stable / Cohort Studies / Coronary Thrombosis / Drug-Eluting Stents / Female / Humans / Male / Middle Aged / Sirolimus / Thrombophilia / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2010.08.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20826025; ● Search Scopus @ Elsevier (PMID): 20826025; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2010.08.014

(DOI: 10.1016/j.ijcard.2010.08.014, PubMed: 20826025) Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Sachiko Bando, Yoichiro Hirata, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability.,
Journal of Cardiology, Vol.58, No.2, 151-157, 2011.

(要約): Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Pentraxin 3 (PTX3) is produced abundantly in atherosclerotic lesions while C-reactive protein (CRP) is mainly produced in the liver. In this study, we investigated whether plasma levels of PTX3 might be a sensitive marker both for the severity of coronary artery disease and vulnerable plaques. Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques. We measured PTX3 concentrations in the peripheral and coronary sinus plasma of 40 patients with angina pectoris (AP) and 20 control subjects. Next, in 28 patients with AP, we determined the correlation between levels of inflammatory molecules and the computed tomography (CT) density of plaques as a quantitative index of plaque vulnerability. There was no significant difference in peripheral plasma PTX3 concentrations between patients with AP and control subjects, while coronary sinus plasma PTX3 concentrations were significantly higher in AP patients than control subjects. The concentrations of PTX3 in coronary sinus and peripheral plasma correlated with Gensini scores as an index of severity of coronary atherosclerosis. Interestingly, there was a significantly negative correlation between plasma PTX3 concentrations and CT density (r=-0.67, p<0.01). On the other hand, CT density did not correlate with the peripheral plasma concentrations of monocyte chemoattractant protein-1 (MCP-1) or high-sensitivity CRP (hsCRP). Furthermore, telmisartan treatment for 6 months decreased plasma concentrations of PTX3 but not those of MCP-1 or hsCRP in 12 patients with essential hypertension. Multivariate regression analysis revealed that changes in PTX3 levels were independent of blood pressure changes. PTX3 is likely more specific than hsCRP as an indicator of coronary plaque vulnerability that could lead to plaque rupture.
(キーワード): Aged / Angina Pectoris / Angiotensin II Type 1 Receptor Blockers / Benzimidazoles / Benzoates / Biological Markers / C-Reactive Protein / Coronary Artery Disease / Coronary Sinus / Disease Progression / Drug Monitoring / Female / Humans / Inflammation Mediators / Male / Middle Aged / Plaque, Atherosclerotic / Serum Amyloid P-Component / Severity of Illness Index / Tomography, Spiral Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2011.04.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21676590; ● Search Scopus @ Elsevier (PMID): 21676590; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2011.04.005

(DOI: 10.1016/j.jjcc.2011.04.005, PubMed: 21676590) Yoichiro Hirata, Minoru Tabata, Hirotsugu Kurobe, Tatsuo Motoki, Masashi Akaike, Chika Nishio, Mayuko Higashida, Hiroaki Mikasa, Yutaka Nakaya, Shuichiro Takanashi, Takashi Igarashi, Tetsuya Kitagawa and Masataka Sata :
Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue.,
Journal of the American College of Cardiology, Vol.58, No.3, 248-255, 2011.

(要約): The purpose of this report was to assess the link between macrophage polarization in epicardial adipose tissue and atherosclerosis in patients with coronary artery disease (CAD).
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jacc.2011.01.048
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21737014; ● Search Scopus @ Elsevier (PMID): 21737014; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jacc.2011.01.048

(DOI: 10.1016/j.jacc.2011.01.048, PubMed: 21737014) Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient.,
International Journal of Cardiology, Vol.150, No.1, e25-e27, 2011.

(要約): A 73-year-old woman suffering from anterior thoracic pain on exertion presented to our hospital. We performed coronary angiography and noted three stenotic legions in each coronary artery. For each angiographic finding, we implanted a bare metal stent (BMS), sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) into the right coronary artery, left anterior descending and left circumflex coronary arteries, respectively. Nine months later, she died of lung disease, and we could compare the histopathological findings among the three coronary stents. In the drug-eluting stents, very thin intima, infiltration of inflammatory cells, and fibrin deposition were observed, while thick intima and no inflammatory findings were observed in the BMS. Fibrin deposition was more marked in the PES than in the SES. This report shows marked differences in the subsequent pathological course among three stents in the same patient.
(キーワード): Aged / Coronary Stenosis / Drug-Eluting Stents / Female / Humans / Paclitaxel / Sirolimus / Stents
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.08.032
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19735952; ● Search Scopus @ Elsevier (PMID): 19735952; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.08.032

(DOI: 10.1016/j.ijcard.2009.08.032, PubMed: 19735952) M Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, N Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation.,
Internal Medicine, Vol.50, No.11, 1201-1206, 2011.

(要約): We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.
(キーワード): Adrenergic beta-Antagonists / Aged / Catheter Ablation / Comorbidity / Defibrillators, Implantable / Female / Humans / Magnetic Resonance Imaging / Sarcoidosis / Tachycardia, Ventricular / Treatment Failure / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.50.4580
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21628935; ● Search Scopus @ Elsevier (PMID): 21628935; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.50.4580

(DOI: 10.2169/internalmedicine.50.4580, PubMed: 21628935) Kenya Kusunose, Hirotsugu Yamada, Noriko Tomita, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis.,
International Journal of Cardiology, Vol.148, No.3, 47-50, 2011.

(要約): Most cases of chronic stenosis or occlusive lesions of the pulmonary arteries are attributed to thromboembolism, and pulmonary arteritis is extremely rare as the primary cause of these entities. We report a case of pulmonary stenosis and occlusion caused by Takayasu arteritis. The patient was a 54-year-old woman who presented with dyspnea. Total occlusion of the left pulmonary artery and significant stenosis of the right pulmonary artery caused by Takayasu arteritis were confirmed by various imaging modalities including pulmonary angiography, (18)fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging and real-time three-dimensional transesophageal echocardiography. After 6 weeks of steroid therapy, follow-up imaging studies showed that the stenotic lesion had resolved.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2009.02.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19299026; ● Search Scopus @ Elsevier (PMID): 19299026; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.02.036

(DOI: 10.1016/j.ijcard.2009.02.036, PubMed: 19299026) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension.,
International Journal of Cardiology, Vol.148, No.1, 125-127, 2011.

(キーワード): Aged / Aged, 80 and over / Female / Hemodynamics / Humans / Hypertension, Pulmonary / Intermittent Positive-Pressure Ventilation / Male / Middle Aged / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2011.01.074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21334081; ● Search Scopus @ Elsevier (PMID): 21334081; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2011.01.074

(DOI: 10.1016/j.ijcard.2011.01.074, PubMed: 21334081) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.,
The American Journal of Cardiology, Vol.107, No.11, 1644-1649, 2011.

(要約): The aim of the present study was to evaluate the factors that modulate the protective action of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal serum lipid profiles, low-dose pitavastatin (1.0 mg/day) was administered to 65 hyperlipidemic patients. The exclusion criteria included left ventricular ejection fraction <40% and apparent renal disease. Age- and gender-matched patients with hyperlipidemia (n = 40) served as the controls. After 12 to 16 weeks of pitavastatin treatment, pitavastatin had decreased low-density lipoprotein cholesterol (from 143.5 ± 31.4 to 98.2 ± 19.4 mg/dl, p <0.01), triglycerides (from 157.7 ± 57.2 to 140.5 ± 60.7 mg/dl, p <0.01), E/e' (from 10.8 ± 6.2 to 9.0 ± 4.5, p <0.05), a parameter of left ventricular diastolic function, and albuminuria (from 47.6 ± 55.9 to 28.5 ± 40.0 mg/g creatinine, p <0.01). Furthermore, pitavastatin decreased serum transforming growth factor-1 (from 709 ± 242 to 550 ± 299 pg/ml, p <0.01), urinary 8-hydroxy-2'-deoxyguanosine (from 6.6 ± 4.1 to 5.0 ± 3.1 g/g creatinine, p <0.01), an oxidative stress marker, and increased urinary nitrate and nitrite (from 22.5 ± 14.6 to 29.4 ± 27.6 nmol/g creatinine, p <0.05). No such changes were observed in the controls. Multiple regression analysis in the pitavastatin group revealed the effect of pitavastatin on cardiorenal function was associated with suppression of oxidative stress, but not on low-density lipoprotein cholesterol reduction. In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress.
(キーワード): Aged / Albuminuria / Case-Control Studies / Cholesterol, LDL / Diastole / Female / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Hyperlipidemias / Male / Middle Aged / Quinolines / Treatment Outcome / Triglycerides / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.amjcard.2011.01.054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21458773; ● Search Scopus @ Elsevier (PMID): 21458773; ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2011.01.054

(DOI: 10.1016/j.amjcard.2011.01.054, PubMed: 21458773) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Yuka Sumitomo-Ueda, Sumiko Yoshida, Toshio Matsumoto and Masataka Sata :
Bosentan improves systemic sclerosis-related peripheral circulation insufficiency.,
International Journal of Cardiology, Vol.147, No.3, 472-475, 2011.

(キーワード): Adult / Aged / Blood Circulation / Female / Humans / Middle Aged / Pain Measurement / Raynaud Disease / Scleroderma, Systemic / Sulfonamides
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijcard.2011.01.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21296436; ● Search Scopus @ Elsevier (PMID): 21296436; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2011.01.025

(DOI: 10.1016/j.ijcard.2011.01.025, PubMed: 21296436) Yoichiro Hirata, Hirotsugu Kurobe, Masashi Akaike, Fumio Chikugo, Takaki Hori, Yoshimi Bando, Chika Nishio, Mayuko Higashida, Yutaka Nakaya, Tetsuya Kitagawa and Masataka Sata :
Enhanced inflammation in epicardial fat in patients with coronary artery disease.,
International Heart Journal, Vol.52, No.3, 139-142, 2011.

(要約): It has been hypothesized that epicardial fat, a local visceral fat depot with close proximity to coronary arteries, may serve as a source of inflammatory cytokines and cells in coronary atherosclerotic lesions. Here, we characterized infiltration of inflammatory cells and expression of adipocytokines in epicardial adipose tissue in patients with and without coronary artery disease (CAD). Pare samples were obtained from epicardial and subcutaneous adipose tissue during elective cardiac surgery (CAD, n = 8; non-CAD, n = 9). Inflammatory cell infiltration was investigated by immunohistochemical staining using antibodies against CD3, CD4, CD8 and CD68. Expression of adipocytokines was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Infiltration of macrophages and CD8-positive T cells in the epicardial adipose tissue in the CAD group was greater than that in the non-CAD group. In contrast, there was no significant difference between the two groups in the number of inflammatory cells in subcutaneous adipose tissue. No statistical difference could be found between the CAD group and the non-CAD group in the expression levels of adiponectin and inflammatory cytokines in epicardial adipose tissue. Our findings suggest that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease. Chronic inflammation in epicardial fat may influence the pathogenesis of coronary atherosclerosis.
(キーワード): Adipokines / Adipose Tissue / Aged / CD8-Positive T-Lymphocytes / Coronary Artery Disease / Female / Humans / Inflammation / Macrophages / Male / Middle Aged / Pericardium / Subcutaneous Tissue
(出版サイトへのリンク): ● Publication site (DOI): 10.1536/ihj.52.139
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21646734; ● Search Scopus @ Elsevier (PMID): 21646734; ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.52.139

(DOI: 10.1536/ihj.52.139, PubMed: 21646734) Shunji Hashizume, Masashi Akaike, Hiroyuki Azuma, Kazue Ishikawa, Sumiko Yoshida, Yuka Ueda, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Ken-ichi Aihara, Masahiro Abe, Masataka Sata and Toshio Matsumoto :
Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets.,
Journal of Atherosclerosis and Thrombosis, Vol.18, No.2, 138-147, 2011.

(要約): Platelet-derived growth factor (PDGF)-BB plays a crucial role in atherosclerosis and vascular remodeling by promoting the migration and proliferation of vascular smooth muscle cells. The objective of this study was to clarify the pleiotropic effect of peroxisome proliferator-activated receptor α (PPARα) activators on PDGF-BB expression in megakaryocytes and platelets. The expression of PPARα in a human erythroleukemia (HEL) cells was clearly detected by reverse transcriptase-PCR and immunofluorescence microscopy. The expression level of PPARα in HEL cells was unchanged regardless of differentiation into megakaryocytic cells by treatment with phorbol 12-myristate 13 acetate (TPA). The TPA-induced expression of PDGF-B mRNA and PDGF-BB protein levels in culture media was significantly decreased by treatment with PPARα activators, Wy14643 and fenofibric acid, in a dose-dependent manner. PDGF-BB expression induced by inflammatory cytokines, including interleukin-1β or interleukin-6, was also significantly suppressed by treatment with PPARα activators. Immunohistochemistry of human bone marrow showed the expression of PPARα in both the nucleus and cytoplasm of megakaryocytes. In addition, PDGF-BB levels in platelets were significantly decreased from 1,800±870 to 1,470±840 pg/10(5) platelets (mean±SD, p<0.05) by treatment with 300 mg fenofibrate once daily for 4 weeks in 13 patients with dyslipidemia. Activation of PPARα in megakaryocytes reduces PDGF-BB expression in platelets. PPARα activators may exert vasculo-protective action through suppression of PDGF-BB production in a megakaryocyte/platelet pathway.
(キーワード): Adult / Blood Platelets / 細胞分化 (cell differentiation) / Cell Line, Tumor / Dyslipidemias / Female / Fenofibrate / 遺伝子発現 (gene expression) / Humans / 免疫組織化学 (immunohistochemistry) / Lipids / Male / Megakaryocytes / Middle Aged / PPAR alpha / Platelet-Derived Growth Factor / Pyrimidines / RNA, Messenger / Tetradecanoylphorbol Acetate
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.5868
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21060209; ● Search Scopus @ Elsevier (PMID): 21060209; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.5868

(DOI: 10.5551/jat.5868, PubMed: 21060209) Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy.,
Circulation Journal, Vol.75, No.1, 141-147, 2011.

(要約): Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Segmental LS was measured by AFI in 60 patients with MI (67 ± 11 years) and 58 controls (71 ± 9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of 11% < LS to identify hypokinetic segments. The overall accuracy of wall motion scoring by LS in the 2,006 segments was 96.8% (κ = 0.90) compared with visual assessment. The correlation coefficient between LS and WT was R² = 0.65 in the 340 segments. Assessment of LV regional asynergy by AFI showed good agreement with visual and SPECT assessments. AFI is clinically useful for quantitative assessment of LV regional wall motion abnormalities.
(キーワード): Aged / Aged, 80 and over / Algorithms / Case-Control Studies / Echocardiography, Doppler / Feasibility Studies / Humans / Image Interpretation, Computer-Assisted / 日本 (Japan) / Middle Aged / Myocardial Contraction / Myocardial Infarction / Myocardial Perfusion Imaging / Observer Variation / Predictive Value of Tests / Reproducibility of Results / Tomography, Emission-Computed, Single-Photon / Ventricular Dysfunction, Left / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0551
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21099120; ● Search Scopus @ Elsevier (PMID): 21099120; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0551

(DOI: 10.1253/circj.CJ-10-0551, PubMed: 21099120) 門田宗之, 竹谷善雄, 若槻哲三, 山口浩司, 楠瀬賢也, 仁木敏之, 坂東左知子, 久岡白陽花, 上田由佳, 冨田紀子, 竹内秀和, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 長井幸二郎, 土井俊夫 :
繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例,
四国医学雑誌, Vol.66, No.5, 6, 175-180, 2010年.

(徳島大学機関リポジトリ): ● Metadata: 110339

(徳島大学機関リポジトリ: 110339) Takayuki Ise, Ken-ichi Aihara, Yuka Ueda, Sumiko Yoshida, Yasumasa Ikeda, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors.,
Hypertension Research, Vol.34, No.2, 225-231, 2010.

(要約): Thrombin has a crucial role in cardiac remodeling through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of cardiac remodeling. We investigated the relationships between plasma HCII activity and surrogate markers of cardiac geometry, including left atrial volume index (LAVI), relative wall thickness (RWT) and left ventricular mass index, and deceleration time (DcT) and the ratio of peak E velocity to early diastolic mitral annulus velocity (E/e' ratio) as surrogate markers of left ventricular diastolic dysfunction measured using echocardiography in 304 Japanese elderly individuals without systolic heart failure (169 men and 135 women; mean age: 65.4 ± 11.8 years). Mean plasma HCII activity in all participants was 95.8 ± 17.0% and there was no difference between the mean plasma HCII activities in males and females. Multiple regression analysis revealed that there were significant inverse relationships between plasma HCII activity and LAVI (coefficient: -0.2302, P<0.001), between HCII activity and RWT (coefficient: -0.0007, P<0.05), between HCII activity and DcT (coefficient: -0.5189, P<0.05) and between HCII activity and E/e' ratio (coefficient: -0.0558, P<0.01). Plasma HCII activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction. These findings suggest that cardiac tissue thrombin inactivation by HCII is a novel therapeutic target for cardiac remodeling and atherosclerosis.
(キーワード): Aged / Cross-Sectional Studies / Female / Heparin Cofactor II / Humans / Male / Middle Aged / Risk Factors / Ventricular Dysfunction / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2010.211
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21107326; ● Search Scopus @ Elsevier (PMID): 21107326; ● Search Scopus @ Elsevier (DOI): 10.1038/hr.2010.211

(DOI: 10.1038/hr.2010.211, PubMed: 21107326) Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.,
Internal Medicine, Vol.49, No.21, 2309-2312, 2010.

(要約): Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.
(キーワード): Exercise / Exercise Test / Female / Humans / Hypertension, Pulmonary / Middle Aged / Scleroderma, Systemic / Sulfonamides
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3812
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21048365; ● CiNii @ 国立情報学研究所 (CRID): 1390282679847104768; ● Search Scopus @ Elsevier (PMID): 21048365; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3812

(DOI: 10.2169/internalmedicine.49.3812, PubMed: 21048365, CiNii: 1390282679847104768) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Sumiko Yoshida, Yuka Ueda, Yasumasa Ikeda, Kazue Ishikawa, Toshio Matsumoto and Masataka Sata :
High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension.,
Hypertension Research, Vol.34, No.1, 74-78, 2010.

(要約): Cognitive impairment leading to dementia is associated with high prevalence of hypertension, decreased quality of life and poor prognosis. Aldosterone is known as a risk factor for cardiovascular and cerebrovascular diseases. In addition, mineral corticoid receptors are abundantly expressed in the hippocampus, which plays a pivotal role in cognitive function; however, it has not been determined whether plasma aldosterone level is associated with cognitive impairment in patients with hypertension. We enrolled 68 patients with essential hypertension and assessed their cardiovascular risk factors, including blood pressure, hyperlipidemia, diabetes mellitus, obesity, smoking, history of cerebral infarction, renal function, parameters of inflammation, oxidative stress and nitric oxide bioavailability, a parameter of cerebral blood flow and carotid plaque by ultrasound examination, plasma renin activity and plasma aldosterone concentration (PAC). The mini-mental state examination (MMSE) was used to evaluate cognitive function. The relevance of cardiovascular risk factors and MMSE score was statistically evaluated. Multiple regression analysis showed that age (P<0.01), PAC (P<0.01) and history of cerebral infarction (P<0.05) were inversely and independently associated with MMSE score. Mineral corticoid receptor antagonists, including spironolactone and eplerenone, increased MMSE score in seven patients with hypertension, but not in the controls. In conclusion, increased PAC is associated with impaired cognitive function and mineral corticoid receptor blockade may protect against not only cardiovascular mortality, but also cognitive impairment in patients with hypertension.Hypertension Research advance online publication, 23 September 2010; doi:10.1038/hr.2010.179.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/hr.2010.179
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20861841; ● Search Scopus @ Elsevier (PMID): 20861841; ● Search Scopus @ Elsevier (DOI): 10.1038/hr.2010.179

(DOI: 10.1038/hr.2010.179, PubMed: 20861841) Yuka Sumitomo-Ueda, Ken-ichi Aihara, Takayuki Ise, Sumiko Yoshida, Yasumasa Ikeda, Ryoko Uemoto, Shusuke Yagi, Takashi Iwase, Kazue Ishikawa, Yoichiro Hirata, Masashi Akaike, Masataka Sata, Shigeaki Kato and Toshio Matsumoto :
Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice.,
Hypertension, Vol.56, No.3, 430-436, 2010.

(要約): Heparin cofactor II (HCII), a serine protease inhibitor, inhibits tissue thrombin action after binding with dermatan sulfate proteoglycans in the extracellular matrix of the vascular system. We previously reported that heterozygous HCII-deficient (HCII(+/-)) humans and mice demonstrate acceleration of vascular remodeling, including atherosclerosis. However, the action of HCII on cardiac remodeling never has been determined. HCII(+/+) and HCII(+/-) mice at age 25 weeks were infused with angiotensin II (Ang II; 2.0 mg/kg/d) for 2 weeks by an osmotic mini-pump. Echocardiography revealed acceleration of cardiac concentric remodeling in HCII(+/-) mice and larger left atrial volume in HCII(+/-) mice than in HCII(+/+) mice. Histopathologic studies showed more prominent interstitial fibrosis in both the left atrium and left ventricle in HCII(+/-) mice than in HCII(+/+) mice. Daily urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and dihydroethidium-positive spots, indicating superoxide production in the myocardium, were markedly increased in Ang II-treated HCII(+/-) mice compared to those in HCII(+/+) mice. Cardiac gene expression levels of atrial natriuretic peptides and brain natriuretic peptides, members of the natriuretic peptide family, Nox 4, Rac-1, and p67(phox) as components of NAD(P)H oxidase, and transforming growth factor-beta1 and procollagen III were more augmented in HCII(+/-) mice than in HCII(+/+) mice. However, administration of human HCII protein attenuated all of those abnormalities in Ang II-treated HCII(+/-) mice. Moreover, human HCII protein supplementation almost abolished cardiac fibrosis in Ang II-treated HCII(+/+) mice. The results indicate that HCII has a protective role against Ang II-induced cardiac remodeling through suppression of the NAD(P)H oxidase-transforming growth factor-beta1 pathway.
(キーワード): Analysis of Variance / Angiotensin II / Animals / Atrial Natriuretic Factor / Cardiomegaly / Echocardiography / Fibrosis / Heart Atria / Heparin Cofactor II / Mice / Mice, Transgenic / Myocardium / Natriuretic Peptide, Brain / Oxidative Stress / Transforming Growth Factor beta1 / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.110.152207
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20660821; ● Search Scopus @ Elsevier (PMID): 20660821; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.110.152207

(DOI: 10.1161/HYPERTENSIONAHA.110.152207, PubMed: 20660821) Hiroaki Yanagawa, Masatoshi Kishuku, Masashi Akaike, Hiroyuki Azuma and Minoru Irahara :
View of physicians on and barriers to patient enrollment in a multicenter clinical trial: experience in a Japanese rural area,
International Archives of Medicine, Vol.3, No.1, 7, 2010.

(要約): Clinical trials in the general practice setting are important for providing evidence on the effectiveness and safety of different agents under various conditions. In conducting these trials, the participation of physicians and patient recruitment are important issues. Various investigations in the literature have reported views and attitudes of physicians on various types of clinical trials. Nevertheless, there is still little information concerning physicians participating in a clinical trial and among them, those who could not recruit any patients (unsuccessful physician recruiters). In 2003, we collaborated in a large-scale multicenter study of Japanese hypertensive patients (COPE Trial). In Tokushima University Hospital and 18 other medical institutions, we investigated the views and attitudes of unsuccessful physician recruiters in comparison with successful physician recruiters, using a questionnaire. The questionnaire was provided by mail to 47 physicians and 27 (57%) responded. The response rate was 79% for successful physician recruiters compared to 43% (P = 0.014) for unsuccessful physician recruiters. More successful physician recruiters (73%) than unsuccessful physician recruiters (42%) stated they had participated and enrolled patients in previous multicenter clinical trials. A significantly higher number of successful physician recruiters than unsuccessful physician recruiters (42%; P = 0.040) considered the presence of a support system with clinical research coordinators (CRC) as the reason for participation (80%). A large number of unsuccessful physician recruiters experienced difficulty in obtaining informed consent (67%), whereas a significantly smaller number of successful physician recruiters experienced such difficulty (20%; P = 0.014). The difficulties experienced by unsuccessful physician recruiters in the trial were as follows: inability to find possible participants (100%), difficulty in obtaining informed consent (58%), cumbersome procedures (58%), difficulty in long-term follow up (33%), and insufficient tools for explanation and obtaining informed consent (8%). This survey showed that successful physician recruiters consider a support system with CRC of value, and that they are skillful in obtaining informed consent. These views and attitudes may have originated from past experience involving clinical trials. In this regard, we need to develop an infrastructure to enlighten physicians on this support system for the promotion of clinical trials.
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1755-7682-3-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20525325; ● Search Scopus @ Elsevier (PMID): 20525325; ● Search Scopus @ Elsevier (DOI): 10.1186/1755-7682-3-7

(DOI: 10.1186/1755-7682-3-7, PubMed: 20525325) Sumiko Yoshida, Ken-ichi Aihara, Hiroyuki Azuma, Ryoko Uemoto, Yuka Sumitomo-Ueda, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Susumu Nishio, Hiromi Kawano, Junko Miki, Hirotsugu Yamada, Yoichiro Hirata, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function.,
Atherosclerosis, Vol.212, No.1, 310-315, 2010.

(要約): BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. However, its biological significance in atherosclerosis remains controversial. Therefore, the aim of this study was to determine whether DHEAS is associated with development of carotid atherosclerosis in subjects with cardiovascular risk factors. SUBJECTS AND METHODS: A total of 419 Japanese individuals (208 males and 211 females) were recruited from Tokushima University Hospital, Japan. In all subjects, maximum intima-media thickness (max-IMT) in all carotid arteries, and mean-IMT and mean blood flow volume (BFV) in the common carotid arteries (CCA) were measured by ultrasonography; endothelial function was assessed by flow-mediated vasodilation of the brachial artery (%FMD). Serum DHEAS and classical cardiovascular risk factors were also evaluated. Statistical significance was determined by multiple regression analysis to elucidate independent determinants of max-IMT, mean-IMT, mean CCA-BFV, and %FMD. RESULTS: Serum DHEAS levels were higher in males than in females. Multiple regression analysis revealed that DHEAS was an independent negative factor for both max-IMT and mean-IMT in males but not in females. In contrast, DHEAS was the sole positive factor for mean CCA-BFV in females but not in males. In addition, there was no significant relationship between %FMD and DHEAS regardless of sex and other confounding factors. CONCLUSION: Although DHEAS is not involved in endothelial function, DHEAS is inversely associated with sex-dependent diverse carotid atherosclerosis such as increased max-IMT and mean-IMT in males and decreased CCA-BFV in females.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2010.05.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20627295; ● Search Scopus @ Elsevier (PMID): 20627295; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2010.05.011

(DOI: 10.1016/j.atherosclerosis.2010.05.011, PubMed: 20627295) Yasumasa Ikeda, Ken-ichi Aihara, Masashi Akaike, Takashi Sato, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yuka Ueda, Sumiko Yoshida, Hiroyuki Azuma, Kenneth Walsh, Toshiaki Tamaki, Shigeaki Kato and Toshio Matsumoto :
Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.,
Molecular Endocrinology, Vol.24, No.7, 1338-1348, 2010.

(要約): Doxorubicin (Dox) has been used as a potent anticancer agent, but serious cardiotoxicity precludes its use in a wide range of patients. We have reported that the androgen-androgen receptor (AR) system plays important roles in cardiac growth and protection from angiotensin II-induced cardiac remodeling. The present study was undertaken to clarify whether the androgen-AR system exerts a cardioprotective effect against Dox-induced cardiotoxicity. Male AR knockout (ARKO) and age-matched littermate male wild-type (WT) mice at 25 wk of age were given ip injections of Dox (20 mg/kg) or a vehicle. The survival rate and left ventricular function in Dox-treated male ARKO mice were reduced compared with those in Dox-treated male WT mice. Electron microscopic study showed prominent vacuole formation of myocardial mitochondria in Dox-treated male ARKO mice. Cardiac oxidative stress and apoptosis of cardiomyocytes were increased more prominently by Dox treatment in male ARKO mice than in male WT mice. In addition, Dox-induced reduction in the expression of cardiac mitochondria transcription factor A (Tfam) and phosphorylation of serine-threonine kinase (Akt) was more pronounced in male ARKO mice than in male WT mice. In cardiac myoblast cells, testosterone up-regulated Akt phosphorylation and Tfam expression and exerted an antiapoptotic effect against Dox-induced cardiotoxicity. Collectively, the results demonstrate that Dox-induced cardiotoxicity is aggravated in male ARKO mice via exacerbation of mitochondrial damage and superoxide generation, leading to enhanced apoptosis of cardiomyocytes. Thus, the androgen-AR system is thought to counteract Dox-induced cardiotoxicity partly through activation of the Akt pathway and up-regulation of Tfam to protect cardiomyocytes from mitochondrial damage and apoptosis.
(キーワード): Androgens / Animals / Antineoplastic Agents / Apoptosis / Blotting, Western / Cell Line / Cell Survival / DNA-Binding Proteins / Doxorubicin / Echocardiography / High Mobility Group Proteins / Immunoprecipitation / In Situ Nick-End Labeling / Male / Mice / Mice, Knockout / Microscopy, Electron / Myocardium / Myocytes, Cardiac / Oxidative Stress / Phosphorylation / Protein-Serine-Threonine Kinases / Rats / Receptors, Androgen / Superoxides / Testosterone / Thiobarbituric Acid Reactive Substances / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1210/me.2009-0402
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20501642; ● Search Scopus @ Elsevier (PMID): 20501642; ● Search Scopus @ Elsevier (DOI): 10.1210/me.2009-0402

(DOI: 10.1210/me.2009-0402, PubMed: 20501642) Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shoichiro Takao, Masafumi Harada, Noriko Kagawa, Eiji Kudo and Masataka Sata :
Images in cardiovascular medicine. Cardiac magnetic resonance imaging and 2-dimensional speckle tracking echocardiography in secondary cardiac amyloidosis.,
Circulation Journal, Vol.74, No.7, 1494-1496, 2010.

(キーワード): Aged / Amyloidosis / Echocardiography / Heart Diseases / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Mitral Valve / Regional Blood Flow
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-10-0141
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20501956; ● Search Scopus @ Elsevier (PMID): 20501956; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-0141

(DOI: 10.1253/circj.CJ-10-0141, PubMed: 20501956) Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions.,
Internal Medicine, Vol.49, No.10, 907-912, 2010.

(要約): Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.
(キーワード): congenital ventricular aneurysm / congenital ventricular diverticulum / ventricular arrythmia
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20467175; ● CiNii @ 国立情報学研究所 (CRID): 1390001204871212928; ● Search Scopus @ Elsevier (PMID): 20467175; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3008

(DOI: 10.2169/internalmedicine.49.3008, PubMed: 20467175, CiNii: 1390001204871212928) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Kazue Ishikawa, Takashi Iwase, Yasumasa Ikeda, Takeshi Soeki, Sumiko Yoshida, Yuka Sumitomo-Ueda, Toshio Matsumoto and Masataka Sata :
Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.,
Hypertension, Vol.55, No.4, 918-923, 2010.

(要約): Activation of the renin-angiotensin system exacerbates atrial remodeling, leading to atrial fibrillation and thrombosis, especially in a condition with decreased NO bioavailability. Recently, it has been reported that statins reduce the incidence of atrial fibrillation through attenuation of atrial remodeling; however, the mechanisms have not been completely elucidated. Therefore, we aimed to clarify the beneficial effect of statin on atrial remodeling in condition with reduced NO bioavailability. Endothelial NO synthase(-/-) mice were sham operated or infused with angiotensin II (Ang II) via an osmotic minipump for 2 weeks, and Ang II-infused mice were divided into 3 treatment groups: pitavastatin, Tempol (a free radical scavenger), or vehicle. Echocardiography and electrocardiography showed that Ang II infusion caused left atrial enlargement and a high incidence of atrial fibrillation, whereas pitavastatin and Tempol prevented these abnormalities. In histological analysis, Ang II-induced atrial interstitial fibrosis, perivascular fibrosis, and cardiomyocyte hypertrophy were all attenuated by pitavastatin and Tempol. Immunohistochemical staining showed that Ang II downregulated thrombomodulin and tissue factor pathway inhibitor and upregulated tissue factor and plasminogen activator inhibitor 1 in the left atrium and that pitavastatin and Tempol corrected the thrombogenic condition. Moreover, pitavastatin and Tempol reduced Ang II-induced atrial superoxide production and atrial transforming growth factor-beta1 expression and Smad 2/3 phosphorylation. Atrial rac1-GTPase activity, known to activate NADPH oxidase, was attenuated by pitavastatin but not by Tempol. In conclusion, pitavastatin exerts endothelial NO synthase-independent protective actions against Ang II-induced atrial remodeling and atrial fibrillation with enhanced thrombogenicity through suppression of oxidant injury.
(キーワード): Analysis of Variance / Angiotensin II / Animals / Antioxidants / Atrial Fibrillation / Blood Pressure / Blotting, Western / Cardiomegaly / Cyclic N-Oxides / Echocardiography / Fibrosis / Heart Atria / Heart Rate / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Male / Mice / Mice, Knockout / Myocytes, Cardiac / Nitric Oxide Synthase Type III / Oxidative Stress / Quinolines / Renin-Angiotensin System / Reverse Transcriptase Polymerase Chain Reaction / Signal Transduction / Smad2 Protein / Smad3 Protein / Spin Labels / Transforming Growth Factor beta1
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/HYPERTENSIONAHA.109.146076
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20194307; ● Search Scopus @ Elsevier (PMID): 20194307; ● Search Scopus @ Elsevier (DOI): 10.1161/HYPERTENSIONAHA.109.146076

(DOI: 10.1161/HYPERTENSIONAHA.109.146076, PubMed: 20194307) Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.,
Journal of Atherosclerosis and Thrombosis, Vol.17, No.2, 173-180, 2010.

(要約): AIM: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. METHODS: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age- and sex-matched patients with hypercholesterolemia (n=38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. RESULTS: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. CONCLUSION: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.
(キーワード): Aged / Albuminuria / Anticholesteremic Agents / Azetidines / C-Reactive Protein / Case-Control Studies / Cholesterol, LDL / Deoxyguanosine / Female / Humans / Hypercholesterolemia / Male / Metabolic Diseases / Metabolic Syndrome X / Middle Aged / Nitrates / Nitrites / Oxidative Stress / Tumor Necrosis Factor-alpha
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.2378
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20150722; ● Search Scopus @ Elsevier (PMID): 20150722; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.2378

(DOI: 10.5551/jat.2378, PubMed: 20150722) Hirotsugu Kurobe, Masahisa Urata, Masaki Ueno, Masaaki Ueki, Shiro Ono, Yuki Izawa-Ishizawa, Yayoi Fukuhara, Yu Lei, Adiratna Mat Ripen, Tamotsu Kanbara, Ken-ichi Aihara, Keisuke Ishizawa, Masashi Akaike, Frank J. Gonzalez, Toshiaki Tamaki, Yousuke Takahama, Masanori Yoshizumi, Tetsuya Kitagawa and Shuhei Tomita :
Role of Hypoxia-Inducible Factor 1α in T Cells as a Negative Regulator in Development of Vascular Remodeling,
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.30, No.2, 210-217, 2010.

(要約): Recent studies have shown that the cellular immune response in the development of vascular remodeling modulates the resulting pathological alterations. We show that hypoxia-inducible factor 1 (Hif-1) (specifically expressed in T cells) is involved in the immune response to vascular remodeling that accompanies arteriosclerosis. To study the role of T cells in the development of vascular remodeling, femoral arterial injury induced by an external vascular polyethylene cuff was examined in mice lacking Hif-1 (specifically in T cells). We found that cuff placement caused prominent neointimal hyperplasia of the femoral artery in Hif-1- (T-cell)-deficient mice compared with that in control mice and that infiltration of inflammatory cells at the adventitia was markedly increased in the mutant mice. Studies to clarify the mechanism of augmented vascular remodeling in the mutant mice showed enhanced production of cytokines by activated T cells and augmented antibody production in response to a T-dependent antigen in the mutant mice. The results of this study revealed that Hif-1alpha in T cells plays a crucial role in vascular inflammation and remodeling in response to cuff injury as a negative regulator of T cell-mediated immune response. Potential new therapeutic strategies that target Hif-1alpha are described.
(キーワード): Animals / Antibody Formation / Arteriosclerosis / Cell Hypoxia / Cell Proliferation / Chemokine CXCL12 / Chemotaxis, Leukocyte / 細胞質分裂 (cytokinesis) / Disease Models, Animal / Femoral Artery / Hyperplasia / Hypoxia-Inducible Factor 1, alpha Subunit / Immunity, Cellular / 免疫組織化学 (immunohistochemistry) / Lymphocyte Activation / 男性 (male) / Mice / ノックアウトマウス (knockout mice) / Nitroimidazoles / Receptors, Antigen, T-Cell / Tリンパ球 (T lymphocytes) / Thymus Gland / Time Factors / Tunica Intima
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/ATVBAHA.109.192666
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20007912; ● Search Scopus @ Elsevier (PMID): 20007912; ● Search Scopus @ Elsevier (DOI): 10.1161/ATVBAHA.109.192666

(DOI: 10.1161/ATVBAHA.109.192666, PubMed: 20007912) Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo-Ueda, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, KI Aihara, Masafumi Harada, H Nishitani and Masataka Sata :
Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.,
Heart Asia, Vol.2, 52-55, 2010.

(出版サイトへのリンク): ● Publication site (DOI): 10.1136/ha.2010.002006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27325943; ● Search Scopus @ Elsevier (PMID): 27325943; ● Search Scopus @ Elsevier (DOI): 10.1136/ha.2010.002006

(DOI: 10.1136/ha.2010.002006, PubMed: 27325943) Masatomo Mihara, Ken-ichi Aihara, Yasumasa Ikeda, Sumiko Yoshida, Mizuho Kinouchi, Kiyoe Kurahashi, Yuichi Fujinaka, Masashi Akaike and Toshio Matsumoto :
Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice.,
Endocrinology, Vol.151, No.2, 513-519, 2009.

(要約): The binding of thrombin to its receptor stimulates inflammatory cytokines including IL-6 and monocyte chemoattractant protein-1 (MCP-1); both are associated with the development of insulin resistance. Because increased adiposity enhanced the expression of coagulation factor VII that stimulates the coagulation pathway in adipose tissue, we tested whether the inhibition of thrombin action ameliorates insulin resistance in obese diabetic (Lpr(-/-):db/db) mice. The 4-wk administration of argatroban, a selective thrombin inhibitor, reduced fasting plasma glucose and ameliorated insulin resistance in these mice. It also reduced adipocyte size and macrophage infiltration into adipose tissue. The aberrant gene expression of MCP-1, IL-6, adiponectin, and factor VII and suppressed insulin receptor substrate-1-Akt signaling in adipose tissue of db/db mice were reversed by argatroban treatment. These results demonstrate that increased adiposity enhances the production of thrombin in adipose tissue by stimulating factor VII expression and suggest that increased thrombin activity in adipose tissue plays an important role in the development of insulin resistance via enhancing MCP-1 production, leading to macrophage infiltration and insulin receptor substrate-1-Akt pathway inactivation.
(出版サイトへのリンク): ● Publication site (DOI): 10.1210/en.2009-0661
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19966184; ● Search Scopus @ Elsevier (PMID): 19966184; ● Search Scopus @ Elsevier (DOI): 10.1210/en.2009-0661

(DOI: 10.1210/en.2009-0661, PubMed: 19966184) Y Hirata, Takeshi Soeki, Masashi Akaike, Y Sakai, T Igarashi and Masataka Sata :
Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.,
Biomedicine & Pharmacotherapy, Vol.63, No.10, 781-786, 2009.

(要約): Impairment of cardiac function in cardiomyopathy has been postulated to be related to decreased blood flow and increased collagen synthesis. Administration of growth factors was reported to attenuate left ventricular (LV) remodeling and dysfunction in animal models of dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor and vascular endothelial growth factor from various cell types and ameliorate ischemia-induced LV dysfunction in mice and pigs. We evaluated therapeutic efficacy of ONO-1301 in the Syrian hamster (TO-2), a model of genetically determined dilated cardiomyopathy. Either vehicle or a slow releasing form of ONO-1301 (ONO-1301-PLGA, 10mg/kg/3 weeks) was administered subcutaneously every 3 weeks to TO-2 hamsters from 24 to 32 weeks of age (n=12 for each group). Age-matched F1B hamsters were used as a control. Plasma concentration of HGF was elevated in ONO-1301-PLGA group (p<0.05). Echocardiographic study demonstrated that LV fractional shortening was significantly improved in the ONO-1301-PLGA group (25+/-4%, p<0.01) compared with that in the vehicle group (19+/-2%). Cardiac fibrosis was significantly reduced by ONO-1301-PLGA (p<0.05) as determined by Azan-Mallory staining. Capillary density of left ventricle was markedly reduced in TO-2 hamsters. ONO-1301-PLGA significantly increased capillary density in TO-2 group (p<0.05). ONO-1301 improved LV dysfunction and reduced cardiac fibrosis in the hamster model of dilated cardiomyopathy. ONO-1301 might hold a therapeutic potential in the treatment of dilated cardiomyopathy.
(キーワード): Animals / Cardiomyopathy, Dilated / Cricetinae / Delayed-Action Preparations / Disease Models, Animal / Drug Carriers / Enzyme Inhibitors / Fibrosis / Lactic Acid / Male / Myocardium / Polyglycolic Acid / Pyridines / Thromboxane-A Synthase / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.biopha.2009.09.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19906506; ● Search Scopus @ Elsevier (PMID): 19906506; ● Search Scopus @ Elsevier (DOI): 10.1016/j.biopha.2009.09.003

(DOI: 10.1016/j.biopha.2009.09.003, PubMed: 19906506) Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, K Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Y Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Utility of Single Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation with Preserved Systolic Function.,
JACC. Cardiovascular Imaging, Vol.2, No.10, 1147-1156, 2009.

(要約): We evaluated the usefulness of the ratio of the early diastolic transmitral flow velocity (E) to the mitral annular velocity (e') calculated from simultaneously recorded E and e' in atrial fibrillation (AF). The ratio of the E to the e' (E/e') has been reported as a useful index even in AF patients. However, E and e' were measured during different beats in the previous studies. Fifty-six AF patients with preserved systolic function (mean age 66 +/- 11 years) underwent routine echocardiographic study. The E/e' was calculated from the E and e' simultaneously recorded by the dual Doppler echocardiography. A single-beat E/e' was calculated from simultaneously recorded E and e' when the preceding RR interval/pre-preceding RR interval = 1. Brain natriuretic peptide (BNP) levels were also examined. Twenty-one patients underwent simultaneous pulmonary artery catheterization. The single-beat lateral E/e' correlated with pulmonary capillary wedge pressure (PCWP) (r = 0.74, p < 0.001). The single-beat lateral E/e' of >or=11 could predict elevated PCWP (>or=15 mm Hg) with a sensitivity of 90% and a specificity of 90%. The single-beat lateral E/e' also correlated well with the log BNP concentration. The single-beat lateral E/e' of >or=9.2 predicted a plasma BNP level of >or=200 pg/ml with 88% sensitivity and 84% specificity. The single-beat lateral E/e' correlated with plasma BNP level and PCWP in AF patients with preserved systolic function. In addition, the single-beat lateral E/e' (>or=11) was a good predictor of elevated PCWP (>or=15 mm Hg). Dual Doppler echocardiography offers an advantage of providing the single-beat lateral E/e' correctly even in AF patients, for the evaluation of left ventricular diastolic function.
(キーワード): Adult / Aged / Aged, 80 and over / Atrial Fibrillation / Biological Markers / Catheterization, Swan-Ganz / Coronary Circulation / Diastole / Echocardiography, Doppler, Color / Echocardiography, Doppler, Pulsed / Female / Heart Rate / Humans / Linear Models / Male / Middle Aged / Mitral Valve / Natriuretic Peptide, Brain / Predictive Value of Tests / Pulmonary Wedge Pressure / Sensitivity and Specificity / Systole / Ventricular Function, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jcmg.2009.05.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19833302; ● Search Scopus @ Elsevier (PMID): 19833302; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcmg.2009.05.013

(DOI: 10.1016/j.jcmg.2009.05.013, PubMed: 19833302) H Iwata, K Nakamura, M Sumi, M Ninomiya, Y Sakai, Y Hirata, Masashi Akaike, T Igarasi, S Takamoto, R Nagai and Masataka Sata :
Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model.,
Life Sciences, Vol.85, No.5-6, 255-261, 2009.

(要約): It was reported that administration of angiogenic growth factors can augment collateral growth in ischemic tissues. It is assumed that angiogenic effects of cell transplantation may be mainly mediated by secretion of angiogenic cytokines. We tested feasibility of clinical use of ONO-1301, a synthetic small molecule that stimulates secretion of growth factors from various cell types, to treat patients with chronic myocardial ischemia. Effects of ONO-1301 on fibroblasts and endothelial cells were evaluated in vitro. We examined the efficacy of local delivery of ONO-1301 in models of rat hindlimb ischemia and swine chronic ischemic myocardium. ONO-1301 stimulated hepatocyte growth factor secretion from human fibroblasts. ONO-1301 promoted vascular-like tube formation by endothelial cells in vitro. Direct injection of a slow-release form of ONO-1301 (SR-ONO) to rat hindlimb ischemic muscle enhanced perfusion recovery. In a swine cardiac ischemia model, direct injection of SR-ONO into the ischemic myocardium significantly augmented collateral formation (SR-ONO vs. control; 1.7+/-0.2 vs. 1.0+/-0.2 Rentrop score), with improved local ventricular wall motion, reduced enlargement of left ventricular diastolic volume (49.5+/-1.9 mL vs. 59.7+/-4.2 mL) and increased cardiac index (4.2+/-0.1 vs. 3.4+/-0.2 L/min/m(2)). Histological analysis revealed that SR-ONO suppressed fibrosis in ischemic tissue (collagen volume fraction; 7.5+/-1.1% vs. 12.8+/-2.2%) and enhanced neovascularization (capillary density, 275.6 vs. 159.3/mm(2); arterioles 36.6 vs. 25.5 /mm(2)). Local delivery of SR-ONO might be effective for therapeutic angiogenesis and propose that local administration of slow-release of synthetic small molecules represents new strategy for therapeutic angiogenesis.
(キーワード): Animals / Cells, Cultured / Collateral Circulation / Delayed-Action Preparations / Disease Models, Animal / Endothelium, Vascular / Fibroblasts / Hepatocyte Growth Factor / Hindlimb / Laser-Doppler Flowmetry / Male / Microcirculation / Myocardial Ischemia / Neovascularization, Pathologic / Prostaglandins I / Pyridines / Rats / Rats, Sprague-Dawley / Swine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lfs.2009.06.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19527738; ● Search Scopus @ Elsevier (PMID): 19527738; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2009.06.002

(DOI: 10.1016/j.lfs.2009.06.002, PubMed: 19527738) Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Hirotsugu Kurobe, Nobuyuki Takamori, Yasumasa Ikeda, Yuka Sumitomo, Sumiko Yoshida, Shusuke Yagi, Takashi Iwase, Kazue Ishikawa, Masataka Sata, Tetsuya Kitagawa and Toshio Matsumoto :
Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors.,
Journal of Atherosclerosis and Thrombosis, Vol.16, No.2, 127-134, 2009.

(要約): AIM: Heparin cofactor II (HCII) specifically inactivates thrombin action at the injured vascular wall. We have reported that HCII is a protective factor against coronary in-stent restenosis and carotid atherosclerosis; however, it is unclear whether there is any correlation between plasma HCII levels and the development of peripheral arterial disease (PAD). METHODS: Plasma HCII activity and the ankle brachial pressure index (ABI) were determined in 494 elderly subjects with cardiovascular risk factors. PAD was diagnosed by ABI below 0.9, and 62 subjects were diagnosed with PAD. The relationship between factors that affect cardiovascular events and the prevalence of PAD was statistically evaluated. RESULTS: Mean HCII activity in PAD subjects was significantly lower than in non-PAD subjects (87.5+/-19.7% v.s. 94.6+/-17.8%, p=0.009). Multivariate logistic regression analysis showed that age (odds ratio [OR]: 1.062, p=0.0016), current smoking (OR 3.028, p=0.002) and diabetes mellitus (OR 2.656, p=0.008) were independent and progressive determinants of PAD. In contrast, HCII was an independent inhibitory factor of PAD (OR: 0.982, p=0.048). CONCLUSIONS: Plasma HCII activity is inversely related to the prevalence of PAD. HCII may function as the sole protective factor against PAD in elderly people with cardiovascular risk factors.
(キーワード): Aged / Aged, 80 and over / Cardiovascular Diseases / Female / Heparin Cofactor II / Humans / Male / Middle Aged / Peripheral Vascular Diseases / Prevalence / Protective Agents / Risk Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.E695
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19403987; ● Search Scopus @ Elsevier (PMID): 19403987; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.E695

(DOI: 10.5551/jat.E695, PubMed: 19403987) 粟飯原賢一, 赤池雅史, 池田康将, 上田由佳, 吉田守美子, 伊勢孝之, 八木秀介, 岩瀬俊, 近藤彰, 田村克也, 松本俊夫 :
アンジオテンシンII受容体拮抗薬バルサルタンのNO bioavailability改善効果に関する臨床的検討,
Progress in Medicine, Vol.29, No.7, 1777-1782, 2009年.

(要約): バルサルタンの降圧作用，動脈硬化抑制作用および糖代謝改善作用に一酸化窒素(NO)のバイオアベイラビリティの改善効果が関与しているか検討した．高血圧治療目的で通院加療中の42例を対象とした．バルサルタン投与にて，BMIやリポプロテイン(a)を含む脂質プロファイルに有意な変化は認めなかったが，収縮期血圧，脈圧，baPWVおよびHbA1cは有意に低下した．投与3ヵ月後には投与前と比較して，NOのバイオアベイラビリティのマーカーである血清硝酸/亜硝酸イオン(NOx)は約1.5倍に増加した．血清NOxの増加が，他の測定因子にどのように影響を与えているか，単変量および多変量解析を用いて解析し，血清NOxの増加量は収縮期血圧の低下と脈圧の減少との間においてそれぞれ有意な相関がみられた．また，HbA1cはバルサルタン投与3ヵ月後に有意に低下していたが，その変化はNOxの増加量と有意な相関がみられた．
(キーワード): Nitrogen Oxides(血液) Glycosylated Hemoglobin A 降圧剤(治療的利用,薬理学) 高血圧(薬物療法) *生物学的利用率動脈硬化症-アテローム性(予防,診断) 経口投与 *一酸化窒素 *Valsartan(治療的利用,薬理学) *Angiotensin II Type 1 Receptor Blockers(治療的利用,薬理学) 脈波伝播速度ヒト中年(45~64) 高齢者(65~79) 男女

Kenya Kusunose, Hirotsugu Yamada, Takashi Todoroki, Susumu Nishio, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Tetsuya Kitagawa and Masataka Sata :
Platypnea-orthodeoxia syndrome associated with patent foramen ovale and aortic ectasia.,
Echocardiography, Vol.26, No.1, 114-117, 2008.

(要約): A 59-year-old man was admitted for dyspnea on exertion and edema. The patient did not have any pulmonary diseases that could cause dyspnea. Transesophageal echocardiography on the tilting bed with contrast infusion revealed a right-to-left shunt through the patent foramen ovale. Therefore, he was diagosed as platypnea-orthodeoxia syndrome due to the patent foramen ovale. Surgical closure was done and all of his symptoms had improved.
(キーワード): Aortic Diseases / Dyspnea / 経食道心エコー (transesophageal echocardiography) / Edema, Cardiac / Foramen Ovale, Patent / Humans / Male / Middle Aged / 症候群 (syndrome) / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1540-8175.2008.00780.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19017323; ● Search Scopus @ Elsevier (PMID): 19017323; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1540-8175.2008.00780.x

(DOI: 10.1111/j.1540-8175.2008.00780.x, PubMed: 19017323) K Yamaguchi, Tetsuzo Wakatsuki, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki and Masashi Akaike :
A case of neurogenic myocardial stunning presenting transient left ventricular mid-portion ballooning simulating atypical takotsubo cardiomyopathy.,
Journal of Cardiology, Vol.52, No.1, 53-58, 2008.

(要約): A 57-year-old female patient, who was initially suspected to have subarachnoid hemorrhage, was admitted to our hospital. She experienced severe dyspnea and chest pain owing to pneumonia on the fourth admission day. Electrocardiography showed ST-segment elevation in leads V(2) through V(5), and echocardiography revealed hypokinetic left ventricular wall motion. No stenosis was found in the coronary arteries by urgent coronary angiography. However, left ventriculography revealed that the basal and apical areas were hyperkinetic and the mid portion was akinetic. After a month, left ventricular wall motion was improved and coronary artery spasm provocation tests were negative. Although the clinical course of this patient was similar to that of neurogenic myocardial stunning, the shape of her left ventricle was not typical.
(キーワード): Coronary Angiography / Diagnosis, Differential / Echocardiography / Electrocardiography / Female / Humans / Middle Aged / Myocardial Stunning / Takotsubo Cardiomyopathy / Ventricular Dysfunction, Left
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jjcc.2008.03.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18639778; ● Search Scopus @ Elsevier (PMID): 18639778; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2008.03.004

(DOI: 10.1016/j.jjcc.2008.03.004, PubMed: 18639778) 赤池雅史, 小原卓爾, 日浅光春, 藤村光則, 加藤みどり, 横井健治, 小島章裕, 岡崎誠司, 井内貴彦, 井上利彦, 住友由佳, 八木秀介, 池田康将, 岩瀬俊, 粟飯原賢一, 東博之 :
高コレステロール血症患者に対するピタバスタチンの有効性総合的脂質プロファイルに関する検討,
Progress in Medicine, Vol.28, No.11, 2745-2751, 2008年.

(要約): 高コレステロール血症患者を対象にピタバスタチンを投与し，総合的脂質プロファイルへの影響について検討した．高コレステロール血症と診断され，ピタバスタチンを投与した87例を対象とした．ピタバスタチン投与によりTC，LDL-Cは有意に低下した．HDL-Cは有意な上昇，TGは有意な低下を認めた．ピタバスタチンを新規に投与した症例で，TC，LDL-Cは有意かつ良好な低下作用を認めた．また，HDL-Cは有意な上昇，TGは有意な低下作用を示した．Non HDL-Cは有意に低下し，LDL-C/HDL-C比は有意に減少した．動脈硬化指数は，いずれも有意に改善した．投与前後でLp(a)を測定した76例で，有意な変化は認めなかった．投与前後におけるALT，ASTの平均変化量に，有意な変化は認めなかった．CKも有意な変化は認めなかった．治療上，問題となる副作用は認めなかった．
(キーワード): Cholesterol(血液) HDL Cholesterol(血液) LDL Cholesterol(血液) Triglycerides(血液) *高コレステロール血症(薬物療法) Lipoprotein(a)(血液) 治療成績 *Pitavastatin(治療的利用) ヒト中年(45~64) 高齢者(65~79) 男女

Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Masataka Sata, Nobuyuki Takamori, Shusuke Yagi, Takashi Iwase, Yuka Sumitomo, Hirotaka Kawano, Takashi Yamada, Toru Fukuda, Takahiro Matsumoto, Keisuke Sekine, Takashi Sato, Yuko Nakamichi, Yoko Yamamoto, Kimihiro Yoshimura, Tomoyuki Watanabe, Takashi Nakamura, Akimasa Oomizu, Minoru Tsukada, Hideki Hayashi, Toshiki Sudo, Shigeaki Kato and Toshio Matsumoto :
Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice,
The Journal of Clinical Investigation, Vol.117, No.6, 1514-1526, 2007.

(要約): Heparin cofactor II (HCII) specifically inhibits thrombin action at sites of injured arterial wall, and patients with HCII deficiency exhibit advanced atherosclerosis. However, the in vivo effects and the molecular mechanism underlying the action of HCII during vascular remodeling remain elusive. To clarify the role of HCII in vascular remodeling, we generated HCII-deficient mice by gene targeting. In contrast to a previous report, HCII(-/-) mice were embryonically lethal. In HCII(+/-) mice, prominent intimal hyperplasia with increased cellular proliferation was observed after tube cuff and wire vascular injury. The number of protease-activated receptor-1-positive (PAR-1-positive) cells was increased in the thickened vascular wall of HCII(+/-) mice, suggesting enhanced thrombin action in this region. Cuff injury also increased the expression levels of inflammatory cytokines and chemokines in the vascular wall of HCII(+/-) mice. The intimal hyperplasia in HCII(+/-) mice with vascular injury was abrogated by human HCII supplementation. Furthermore, HCII deficiency caused acceleration of aortic plaque formation with increased PAR-1 expression and oxidative stress in apoE-KO mice. These results demonstrate that HCII protects against thrombin-induced remodeling of an injured vascular wall by inhibiting thrombin action and suggest that HCII is potentially therapeutic against atherosclerosis without causing coagulatory disturbance.
(キーワード): Animals / Base Sequence / Blood Vessels / DNA Primers / Embryo Loss / Female / Gene Targeting / Genes, Lethal / Genotype / Heparin Cofactor II / Heterozygote / Homozygote / Male / Mice / Mice, Inbred C57BL / ノックアウトマウス (knockout mice) / Pregnancy
(出版サイトへのリンク): ● Publication site (DOI): 10.1172/JCI27095
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17549254; ● Search Scopus @ Elsevier (PMID): 17549254; ● Search Scopus @ Elsevier (DOI): 10.1172/JCI27095

(DOI: 10.1172/JCI27095, PubMed: 17549254) Yasumasa Ikeda, Shusuke Yagi, Hiroshi Yamaguchi, Mitsunori Fujimura, Shunji Hashizume, Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma and Toshio Matsumoto :
Intra-vascular ultrasound findings of diffuse coronary atherosclerotic change in systemic lupus erythematosus with secondary antiphospholipid syndrome,
Circulation Journal, Vol.70, No.8, 1082-1085, 2006.

(要約): Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are autoimmune inflammatory diseases associated with juvenile atherosclerosis and thrombosis, respectively. A 44-year-old woman who had SLE with secondary APS had been treated with corticosteroid therapy, however, her inflammatory marker had never been within a normal range in her clinical course, and finally acute myocardial infarction was developed. Intra-vascular ultrasound also revealed diffuse coronary atherosclerosis progression for her age, which might result from SLE and APS, including vascular inflammation.
(キーワード): Adrenal Cortex Hormones / Adult / Antiphospholipid Syndrome / Coronary Artery Disease / Coronary Vessels / Female / Humans / Lupus Erythematosus, Systemic / Myocardial Infarction / Ultrasonography, Interventional
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.70.1082
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16864946; ● Search Scopus @ Elsevier (PMID): 16864946; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.70.1082

(DOI: 10.1253/circj.70.1082, PubMed: 16864946) Y. Kuroda, Takao Mitsui, M. Kunishige, Masayuki Shono, Masashi Akaike, H. Azuma and Toshio Matsumoto :
Parkin enhances mitochondrial biogenesis in proliferating cells.,
Human Molecular Genetics, Vol.15, No.6, 883-895, 2006.

(要約): We describe a novel function of parkin, a RING protein, which is elaborately involved in mitochondrial biogenesis. Parkin was located within the mitochondrial organelle of proliferating cells. Anti-proliferative treatments released parkin from mitochondria to cytosol. Results of pharmacological treatments indicate that parkin was released from mitochondria when permeability transition pore was opened. The extra-mitochondrial localization was also observed in differentiated cells. In proliferating cells, transcription and replication of mitochondrial DNA was enhanced by parkin overexpression and attenuated by parkin suppression with siRNA. Parkin was associated with mitochondrial transcription factor A (TFAM) and enhanced TFAM-mediated mitochondrial transcription. These results indicate that parkin is involved in the regulation of mitochondrial transcription/replication other than the ubiquitin-mediated protein degradation system in proliferating cells.
(キーワード): Parkin / ミトコンドリア (mitochondria)
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/hmg/ddl006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16449237; ● Search Scopus @ Elsevier (PMID): 16449237; ● Search Scopus @ Elsevier (DOI): 10.1093/hmg/ddl006

(DOI: 10.1093/hmg/ddl006, PubMed: 16449237) Yasumasa Ikeda, Ken-ichi Aihara, Takashi Sato, Masashi Akaike, Masanori Yoshizumi, Yuki Suzaki, Yuki Izawa-Ishizawa, Mitsunori Fujimura, Shunji Hashizume, Midori Kato, Shusuke Yagi, Toshiaki Tamaki, Hirotaka Kawano, Takahiro Matsumoto, Hiroyuki Azuma, Shigeaki Kato and Toshio Matsumoto :
Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis.,
The Journal of Biological Chemistry, Vol.280, No.33, 29661-29666, 2005.

(要約): Androgen has anabolic effects on cardiac myocytes and has been shown to enhance left ventricular enlargement and function. However, the physiological and patho-physiological roles of androgen in cardiac growth and cardiac stress-induced remodeling remains unclear. We aimed to clarify whether the androgen-nuclear androgen receptor (AR) system contributes to the cardiac growth and angiotensin II (Ang II)-stimulated cardiac remodeling by using systemic AR-null male mice. AR knock-out (ARKO) male mice, at 25 weeks of age, and age-matched wild-type (WT) male mice were treated with or without Ang II stimulation (2.0 mg/kg/day) for 2 weeks. ARKO mice with or without Ang II stimulation showed a significant reduction in the heart-to-body weight ratio compared with those of WT mice. In addition, echocardiographic analysis demonstrated impairments of both the concentric hypertrophic response and left ventricular function in Ang II-stimulated ARKO mice. Western blot analysis of the myocardium revealed that activation of extracellular signal-regulated kinases (ERK) 1/2 and ERK5 by Ang II stimulation were lower in ARKO mice than those of WT mice. Ang II stimulation caused more prominent cardiac fibrosis in ARKO mice than in WT mice with enhanced expression of types I and III collagen and transforming growth factor-beta1 genes and with increased Smad2 activation. These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress.
(キーワード): Angiotensin II / Animals / 血圧 (blood pressure) / Cardiomegaly / DNA-Binding Proteins / 肺線維症 (pulmonary fibrosis) / Heart Rate / Male / Mice / Mice, Inbred C57BL / Mice, Inbred CBA / ノックアウトマウス (knockout mice) / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Mitogen-Activated Protein Kinase 7 / 心筋 (myocardium) / RNA, Messenger / Receptors, Androgen / Smad2 Protein / Trans-Activators / Transforming Growth Factor beta / Transforming Growth Factor beta1 / Ventricular Remodeling
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M411694200
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15961403; ● Search Scopus @ Elsevier (PMID): 15961403; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M411694200

(DOI: 10.1074/jbc.M411694200, PubMed: 15961403) Midori Kato, Hiroyuki Azuma, Masashi Akaike, Takahiko Iuchi, Ken-ichi Aihara, Yasumasa Ikeda, Mitsunori Fujimura, Tomonori Yoshida, Hiroshi Yamaguchi, Shunji Hashizume and Toshio Matsumoto :
Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression.,
Atherosclerosis, Vol.183, No.1, 49-55, 2005.

(要約): OBJECTIVE: We hypothesized that aspirin may exhibit its anti-atherosclerotic effects via mechanisms other than cyclooxygenase inhibition in platelets. METHODS AND RESULTS: Using enhanced subtraction hybridization analysis, we found in human umbilical vein endothelial cells (HUVECs) that aspirin up-regulates the expression of aminopeptidase N (APN/CD13) mRNA and its surface protein levels in a dose-dependent manner. Enzymatic activity of APN/CD13 on HUVECs was increased approximately 1.5-fold by 1 mmol L(-1) of aspirin, and treatment with bestatin, an inhibitor for APN/CD13 metalloprotease activity, attenuated the enhanced activities of APN/CD13. Since activated thrombin receptor is reported to be inactivated by APN/CD13 in vitro, protective actions of aspirin on HUVECs by thrombin stimulation were examined, resulting in the suppression of endothelin-1 and reactive oxygen species productions in HUVECs. These inhibitory actions of aspirin were partially abrogated by bestatin. CONCLUSIONS: Aspirin may exert its anti-atherothrombotic effects in part via the inhibition of thrombin action by up-regulating APN/CD13 on endothelial cells.
(キーワード): Antigens, CD13 / Aspirin / Cells, Cultured / Endothelial Cells / Endothelin-1 / Endothelium, Vascular / Enzyme Induction / Fibrinolytic Agents / Genes, Reporter / Humans / Leucine / Protease Inhibitors / RNA, Messenger / 活性酸素 (reactive oxygen species) / Subtraction Technique / Thrombin / Transcription, Genetic / Transfection / Umbilical Veins
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2005.03.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16216591; ● Search Scopus @ Elsevier (PMID): 16216591; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2005.03.003

(DOI: 10.1016/j.atherosclerosis.2005.03.003, PubMed: 16216591) Tomonori Yoshida, Hiroyuki Azuma, Ken-ichi Aihara, Mitsunori Fujimura, Masashi Akaike, Takao Mitsui and Toshio Matsumoto :
Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery,
Atherosclerosis, Vol.178, No.1, 39-47, 2005.

(要約): Consistent with the physiological response to increased energy demand in proliferating cells, the number of mitochondria is upregulated in synthetic states of vascular smooth muscle cells (VSMC) in atherosclerotic lesion. We hypothesized that mitochondrial transcription factor A (mtTFA), a prerequisite factor for the transcription and replication of mtDNA, may be upregulated in VSMC of injured rat carotid artery, and that inhibition of its expression can attenuate the intimal thickening. Changes of intimal thickening and mtTFA expression by a treatment with antisense oligodeoxynucleotides (ODN) for mtTFA were investigated in balloon-injured rat carotid artery model. The expression of mtTFA was upregulated as early as 3 h up to 7 days after balloon injury. Delivery of ansisense ODN for mtTFA from adventitia side to injured arterial wall caused a significant decrease in intima-to-media (I/M) ratio. Furthermore, the increase in immunoreactivity and mRNA expression of mtTFA in injured artery as well as the number of mitochondria in intimal VSMC was abrogated by antisense ODN treatment. These data demonstrate that expression of mtTFA is upregulated in intimal VSMC of injured rat carotid artery, and that suppression of mtTFA expression by antisense ODN can attenuate intimal thickening after balloon injury.
(キーワード): Antisense oligodeoxynucleotide / Arterial injury / Intimal thickening / Dedifferentiation / Restenosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.atherosclerosis.2004.08.029
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15585199; ● Search Scopus @ Elsevier (PMID): 15585199; ● Search Scopus @ Elsevier (DOI): 10.1016/j.atherosclerosis.2004.08.029

(DOI: 10.1016/j.atherosclerosis.2004.08.029, PubMed: 15585199) 山口普史, 池田康将, 藤村光則, 森岡将臣, 橋詰俊二, 加藤みどり, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫, 稲山真美, 埴淵昌毅 :
アミオダロン肺合併症との鑑別を要したマイコプラズマ肺炎合併拡張型心筋症の1例,
Progress in Medicine, Vol.25, No.Suppl.1, 1552-1556, 2005年.

(要約): 52歳男.47歳時に拡張型心筋症と診断され,持続性心室頻拍でアミオダロン150mg/日を開始した.その後,心室頻拍が頻回となり,心臓電気生理学的検査で心室細動が誘発されたため除細動器植込み術を受け,アミオダロンは増量して継続していた.今回,乾性咳が出現し,胸部X線で左右下肺野にスリガラス状陰影を指摘された.検査所見では高度の炎症所見を認めたが,KL-6は正常範囲で,C型肝炎ウイルスとヒトT細胞性白血病ウイルスI型のキャリアであった.胸部CTでは両側下肺野を中心として壁の肥厚を伴う気管支拡張や小葉中心性の粒状・樹枝状の陰影が多発しており,周囲の肺野に淡い濃度上昇を認めた.アミオダロンの副作用か感染症かは判断できなかったが,アミオダロンは中止し,アンピシリンナトリウム・スルバクタムナトリウム合剤を開始すると共にサイトメガロウイルス高力価免疫グロブリン投与を行った.入院10日目にマイコプラズマ抗体異常高値が判明し,マイコプラズマ肺炎と診断しミノサイクリン100mg/日を開始した.その結果,炎症所見,画像所見は徐々に軽快し,アミオダロンも再開して退院となった
(キーワード): *Amiodarone(治療的利用,毒性・副作用) Minocycline(治療的利用) 胸部X線診断 *心筋症-拡張型(合併症) 鑑別診断 X線CT 肺炎-マイコプラズマ性(合併症,X線診断) 頻拍-心室性(薬物療法) 肺炎-細菌性(合併症,X線診断,薬物療法) 肺炎-間質性(化学的誘発,X線診断) 胸部CT ヒト中年(45~64) 男

Masashi Akaike, Wenyi Che, Nicole-Lerner Marmarosh, Shinsuke Ohta, Masaki Osawa, Bo Ding, Bradford C. Berk, Chen Yan and Jun-ichi Abe :
The Hinge-Helix 1 Region of Peroxisome Proliferator-Activated Receptor γ1 (PPARγ1) Mediates Interaction with Extracellular Signal-Regulated Kinase 5 and PPARγ1 Transcriptional Activation, --- Involvement in Flow-Induced PPARγ Activation in Endothelial Cells ---,
Molecular and Cellular Biology, Vol.24, No.19, 8691-8704, 2004.

(要約): Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that form a subfamily of the nuclear receptor gene family. Since both flow and PPARgamma have atheroprotective effects and extracellular signal-regulated kinase 5 (ERK5) kinase activity is significantly increased by flow, we investigated whether ERK5 kinase regulates PPARgamma activity. We found that activation of ERK5 induced PPARgamma1 activation in endothelial cells (ECs). However, we could not detect PPARgamma phosphorylation by incubation with activated ERK5 in vitro, in contrast to ERK1/2 and JNK, suggesting a role for ERK5 as a scaffold. Endogenous PPARgamma1 was coimmunoprecipitated with endogenous ERK5 in ECs. By mammalian two-hybrid analysis, we found that PPARgamma1 associated with ERK5a at the hinge-helix 1 region of PPARgamma1. Expressing a hinge-helix 1 region PPARgamma1 fragment disrupted the ERK5a-PPARgamma1 interaction, suggesting a critical role for hinge-helix 1 region of PPARgamma in the ERK5-PPARgamma interaction. Flow increased ERK5 and PPARgamma1 activation, and the hinge-helix 1 region of the PPARgamma1 fragment and dominant negative MEK5beta significantly reduced flow-induced PPARgamma activation. The dominant negative MEK5beta also prevented flow-mediated inhibition of tumor necrosis factor alpha-mediated NF-kappaB activation and adhesion molecule expression, including vascular cellular adhesion molecule 1 and E-selectin, indicating a physiological role for ERK5 and PPARgamma activation in flow-mediated antiinflammatory effects. We also found that ERK5 kinase activation was required, likely by inducing a conformational change in the NH(2)-terminal region of ERK5 that prevented association of ERK5 and PPARgamma1. Furthermore, association of ERK5a and PPARgamma1 disrupted the interaction of SMRT and PPARgamma1, thereby inducing PPARgamma activation. These data suggest that ERK5 mediates flow- and ligand-induced PPARgamma activation via the interaction of ERK5 with the hinge-helix 1 region of PPARgamma.
(キーワード): Endothelial Cells / Gene Expression Regulation / Humans / MAP Kinase Kinase Kinases / Mitogen-Activated Protein Kinase 7 / Mitogen-Activated Protein Kinases / NF-kappa B / Phosphorylation / Protein Structure, Tertiary / Receptors, Cytoplasmic and Nuclear / Thiazolidinediones / Transcription Factors / Tumor Necrosis Factor-alpha / Vascular Cell Adhesion Molecule-1
(出版サイトへのリンク): ● Publication site (DOI): 10.1128/MCB.24.19.8691-8704.2004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15367687; ● Search Scopus @ Elsevier (PMID): 15367687; ● Search Scopus @ Elsevier (DOI): 10.1128/MCB.24.19.8691-8704.2004

(DOI: 10.1128/MCB.24.19.8691-8704.2004, PubMed: 15367687) Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Michiko Yamashita, Toshiki Sudo, Hideki Hayashi, Yoshihisa Yamada, Fuminari Endoh, Mitsunori Fujimura, Tomonori Yoshida, Hiroshi Yamaguchi, Shunji Hashizume, Midori Kato, Kimihiro Yoshimura, Yoko Yamamoto, Shigeaki Kato and Toshio Matsumoto :
Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice,
The Journal of Biological Chemistry, Vol.279, No.34, 35798-35802, 2004.

(要約): Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis, cell differentiation, and regulation of the immune system. Expression of these genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous studies have shown that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined in normocalcemic VDR knock-out (KO) mice on a high calcium diet and compared with wild type and hypocalcemic VDRKO mice that were fed a regular diet. Platelet aggregation was enhanced significantly in normocalcemic VDRKO mice compared with wild type and hypocalcemic VDRKO mice. Aortic endothelial nitric-oxide (NO) synthase expression and urinary NOx excretions were reduced in hypocalcemic VDRKO mice, but not in normocalcemic VDRKO mice. Northern blot and RT-PCR analyses revealed that the gene expression of antithrombin in the liver as well as that of thrombomodulin in the aorta, liver and kidney was down-regulated in hypo- and normocalcemic VDRKO mice. Whereas tissue factor mRNA expression in the liver and kidney was up-regulated in VDRKO mice regardless of plasma calcium level. Furthermore, VDRKO mice manifested an exacerbated multi-organ thrombus formation after exogenous lipopolysaccharide injection regardless of the calcemic conditions. These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis.
(キーワード): FILTRATION PRESSURE METHOD / TISSUE-FACTOR / 1,25-DIHYDROXYVITAMIN D-3 / ANTITHROMBIN DEFICIENCY / WHOLE-BLOOD / EXPRESSION / 細胞 (cells) / AGGREGATION / 阻害 (inhibition) / ALOPECIA
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M404865200
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15205460; ● CiNii @ 国立情報学研究所 (CRID): 1362262945661168512; ● Summary page in Scopus @ Elsevier: 2-s2.0-4143096123

(DOI: 10.1074/jbc.M404865200, PubMed: 15205460, CiNii: 1362262945661168512, Elsevier: Scopus) Ken-ichi Aihara, Hiroyuki Azuma, Nobuyuki Takamori, Yasuhiko Kanagawa, Masashi Akaike, Mitsunori Fujimura, Tomonori Yoshida, Shunji Hashizume, Midori Kato, Hiroshi Yamaguchi, Shuji Kato, Yasumasa Ikeda, Tomoko Arase, Akira Kondo and Toshio Matsumoto :
Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals.,
Circulation, Vol.109, No.22, 2761-2765, 2004.

(要約): Thrombin plays a crucial role in atherothrombotic changes. Because heparin cofactor II (HCII) inhibits thrombin actions after binding to dermatan sulfate at injured arterial walls, HCII may negatively regulate thrombin actions in vascular walls. We hypothesized that plasma HCII activity is a preventive factor against atherosclerotic changes, especially in elderly individuals who already have atherosclerotic vascular injuries. Maximum plaque thickness (MPT) in the carotid artery was measured by ultrasonography in 306 Japanese elderly individuals (154 men and 152 women; age, 40 to 91 years; 68.9+/-11.1 years, mean+/-SD). The relevance of cardiovascular risk factors including plasma HCII activity to the severity of MPT was statistically evaluated. Plasma HCII activity decreased with age. Simple linear regression analysis after adjustments for age and sex showed that lipoprotein(a), glycosylated hemoglobin A1c, and presence of diabetes mellitus significantly contributed to an increase in MPT values (r=0.119, P<0.05; r=0.196, P<0.001; and r=0.227, P<0.0001, respectively). In contrast, high-density lipoprotein (HDL) cholesterol and HCII activity were negatively correlated with MPT values (r=-0.117, P<0.05, and r=-0.202, P<0.0005, respectively). Multiple regression analysis revealed that plasma HCII activity and HDL cholesterol independently contributed to the suppression of MPT values and that the antiatherogenic contribution of HCII activity was stronger than that of HDL cholesterol (P<0.001 and P<0.05, respectively). These results suggest that HCII can be a novel and independent antiatherogenic factor. Moreover, HCII is a stronger predictive factor than HDL cholesterol against carotid atherosclerosis in elderly individuals.
(キーワード): Adult / Aged / Aged, 80 and over / 加齢 (aging) / Antithrombins / Cardiovascular Diseases / Carotid Artery Diseases / Female / Heparin Cofactor II / Humans / Male / Middle Aged / Regression Analysis / Risk Factors / Severity of Illness Index
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.CIR.0000129968.46095.F3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15148272; ● Search Scopus @ Elsevier (PMID): 15148272; ● Search Scopus @ Elsevier (DOI): 10.1161/01.CIR.0000129968.46095.F3

(DOI: 10.1161/01.CIR.0000129968.46095.F3, PubMed: 15148272) 赤池雅史, 東博之, 石川雅康, 井上利彦, 遠藤武徳, 岡崎誠司, 小島章裕, 佐藤幸一, 田村克也, 田村隆一, 長楽雅仁, 中平晴仁, 林郁郎, 日浅光春, 藤村光則, 松本直也, 宮恵子, 山口普史, 吉田健三, 渡部滋夫, 松本俊夫 :
日本動脈硬化学会による診療ガイドラインからみた高コレステロール血症治療の動向とその問題点, --- 四国高脂血症スタディ(続報) ---,
Progress in Medicine, Vol.24, No.3, 767-772, 2004年. Nobuyuki Takamori, Hiroyuki Azuma, Midori Kato, Shunji Hashizume, Ken-ichi Aihara, Masashi Akaike, Katsuya Tamura and Toshio Matsumoto :
High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention,
Circulation, Vol.109, No.4, 481-486, 2004.

(要約): Thrombin plays an important role in the development of atherosclerosis and restenosis after percutaneous coronary intervention. Because heparin cofactor II (HCII) inhibits thrombin action in the presence of dermatan sulfate, which is abundantly present in arterial wall, HCII may affect vascular remodeling by modulating thrombin action. We hypothesized that patients with high plasma HCII activity may show a reduced incidence of in-stent restenosis (ISR). Sequential coronary arteries (n=166) with NIR stent (Boston Scientific Corp) implantation in 134 patients were evaluated before, immediately after, and at 6 months after percutaneous coronary intervention. Patients were divided into the following groups: high HCII (> or =110%, 45 lesions in 36 patients), normal HCII (> or =80% and <110%, 81 lesions in 66 patients), and low HCII (<80%, 40 lesions in 32 patients). Percent diameter stenosis at follow-up in the high-HCII group (18.7%) was significantly lower (P=0.046) than that in the normal-HCII group (30.3%) or the low-HCII group (29.0%). The ISR rate in the high-HCII group (6.7%) was significantly lower than that in the low-HCII group (30.0%) (P=0.0039). Furthermore, multivariate analysis demonstrated that high plasma HCII activity is an independent factor in reducing the incidence of angiographic restenosis (odds ratio, 0.953/1% increase of HCII; 95% CI, 0.911 to 0.998). The results demonstrate that HCII may have a hitherto unrecognized effect in inhibiting ISR. The effect of HCII may be mediated by inactivating thrombin in injured arteries, thereby inhibiting vascular smooth muscle cell migration and proliferation.
(キーワード): cardiovascular diseases / angioplasty / atherosclerosis / thrombin / dermatan sulfate
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.CIR.0000109695.39671.37
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14744972; ● Search Scopus @ Elsevier (PMID): 14744972; ● Search Scopus @ Elsevier (DOI): 10.1161/01.CIR.0000109695.39671.37

(DOI: 10.1161/01.CIR.0000109695.39671.37, PubMed: 14744972) Itsuro Endo, Daisuke Inoue, Takao Mitsui, Yoshifumi Umaki, Masashi Akaike, Tatsuya Yoshizawa, Shigeaki Kato and Toshio Matsumoto :
Deletion of Vitamin D Receptor Gene in Mice Results in Abnormal Skeletal Muscle Development with Deregulated Expression of Myoregulatory Transcription Factors,
Endocrinology, Vol.144, No.12, 5138-5144, 2003.

(キーワード): D RESPONSE SEQUENCE / PARATHYROID-HORMONE / 1,25-DIHYDROXYVITAMIN-D3 RECEPTORS / 代謝 (metabolism) / RICKETS / FALLS / RAT / 同定 (identification) / OSTEOMALACIA / MECHANISMS
(出版サイトへのリンク): ● Publication site (DOI): 10.1210/en.2003-0502
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12959989; ● Search Scopus @ Elsevier (PMID): 12959989; ● Search Scopus @ Elsevier (DOI): 10.1210/en.2003-0502

(DOI: 10.1210/en.2003-0502, PubMed: 12959989) 粟飯原賢一, 東博之, 赤池雅史, 藤村光則, 吉田智則, 橋詰俊二, 加藤みどり, 山口普史, 池田康将, 加藤茂明, 松本俊夫 :
ビタミンD-ビタミンD受容体システムは生体における血液凝固調節因子である,
第25回日本血栓止血学会学術集会, Vol.14, No.5, 420, 2003年.

(キーワード): *Vitamin D(薬理学) 遺伝子発現血液凝固 Calcitriol Receptors Thrombomodulin マウス動物

Takao Mitsui, Yoshifumi Umaki, Masakazu Nagasawa, Masashi Akaike, Satoshi Ohtsuka, Masaaki Odomi, Kenji Aki and Toshio Matsumoto :
Motor neuron involvement in a patient with long-term corticosteroid administration,
Internal Medicine, Vol.42, No.9, 862-866, 2003.

(要約): An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10. These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases.
(キーワード): asthma / corticosteroid myopathy / denervation / neurogenic muscular atrophy / ミトコンドリア (mitochondria)
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.42.862
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14518677; ● CiNii @ 国立情報学研究所 (CRID): 1390282679843291136; ● Search Scopus @ Elsevier (PMID): 14518677; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.42.862

(DOI: 10.2169/internalmedicine.42.862, PubMed: 14518677, CiNii: 1390282679843291136) Nicole Lerner-Marmarosh, Masanori Yoshizumi, Wenyi Che, James Surapisitchat, Masashi Akaike, Bo Ding, Qunhua Huang, Chen Yan, Bradford C. Berk and Jun-ichi Abe :
Inhibition of Tumor Necrosis Factor- Induced SHP-2 Phosphatase Activity by Shear Stress,
Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.23, No.10, 1775-1781, 2003.

(要約): Atherosclerosis preferentially occurs in areas of turbulent flow, whereas laminar flow is atheroprotective. Inflammatory cytokines have been shown to stimulate adhesion molecule expression in endothelial cells that may promote atherosclerosis, in part, by stimulating c-Jun N-terminal kinase (JNK) and nuclear factor (NF)-kappaB transcriptional activity. Because Src kinase family and Src homology region 2-domain phosphatase-2 (SHP-2) may regulate JNK activation, we studied the effect of shear stress on endothelial inflammation and JNK. Human umbilical vein endothelial cells preexposed to flow showed decreased tumor necrosis factor (TNF)-alpha-induced c-Jun and NF-kappaB transcriptional activation. TNF-alpha-mediated JNK, c-Jun, and NF-kappaB activation required Src and SHP-2 activity. Shear stress significantly inhibited SHP-2 phosphatase activity without affecting TNF-alpha-induced Src family kinase activation. Because MEKK3 and Gab1 are critical for TNF-alpha-induced c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling. A catalytically inactive form of SHP-2 increased MEKK3/Gab1 interaction and inhibited MEKK3 (but not MEKK1)-mediated c-Jun and NF-kappaB activation. These results suggest that SHP-2 is a key mediator for the inhibitory effects of shear stress on TNF-alpha signaling in part via regulating MEKK3/Gab1 interaction, MEKK3 signaling, and subsequent adhesion molecule expression.
(キーワード): pathophysiology / cell signaling / endothelium / mechanism of atherosclerosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.ATV.0000094432.98445.36
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12947019; ● Search Scopus @ Elsevier (PMID): 12947019; ● Search Scopus @ Elsevier (DOI): 10.1161/01.ATV.0000094432.98445.36

(DOI: 10.1161/01.ATV.0000094432.98445.36, PubMed: 12947019) Makoto Kunishige, Takao Mitsui, Masashi Akaike, Masakazu Kawajiri, Masayuki Shono, Hisaomi Kawai and Toshio Matsumoto :
Overexpressions of myoglobin and antioxidant enzymes in ragged-red fibers of skeletal muscle from patients with mitochondrial encephalomyopathy,
Muscle & Nerve, Vol.28, No.4, 484-492, 2003.

(要約): To determine the relationship between myoglobin (Mb) and the defense system against reactive oxygen species in various myopathies, we performed immunohistochemical analyses of Mb and various antioxidant enzymes, including manganese superoxide dismutase (Mn-SOD), copper zinc SOD (CuZn-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Biopsied muscle specimens were obtained from patients with chronic progressive external ophthalmoplegia (CPEO), Kearns-Sayre syndrome (KSS), Duchenne muscular dystrophy (DMD), and polymyositis (PM). In patients with CPEO/KSS, stainings of Mb, SOD, CAT, and GSH-Px in nonatrophic ragged-red fibers (RRFs) were more intense than those in non-RRFs. These pronounced stainings corresponded to ragged-red lesions. The staining intensities of these antioxidant enzymes were significantly correlated with that of Mb (P < 0.001). Atrophic RRFs in specimens from patients with CPEO/KSS showed intense stainings of these antioxidant enzymes but not intense staining of Mb. In specimens from patients with DMD/PM, the antioxidant enzymes but not Mb were overexpressed in degenerative fibers. These results suggest that oxidative stress is associated with Mb expression specifically in mitochondrial diseases. The antioxidant enzymes seem to be upregulated to protect against muscle damage in nonatrophic RRFs. However, the Mb-mediated oxidative damage may become more extensive and result in further mitochondrial dysfunction and progressive atrophy of RRF with impaired upregulation of Mb.
(キーワード): catalase / glutathione peroxidase / oxgen radical / ragged-red fibers / superoxide dismutase
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mus.10466
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14506721; ● Search Scopus @ Elsevier (PMID): 14506721; ● Search Scopus @ Elsevier (DOI): 10.1002/mus.10466

(DOI: 10.1002/mus.10466, PubMed: 14506721) Mitsunori Fujimura, Masashi Akaike, Midori Kato, Nobuyuki Takamori, Masahiro Abe, Takeshi Nishiuchi, Hiroyuki Azuma and Toshio Matsumoto :
Aggressive antiplatelet therapy before coronary stent implantation in acute coronary syndrome with essential thrombocythemia--a case report,
Angiology, Vol.54, No.4, 485-490, 2003.

(要約): A 52-year-old man was admitted to the hospital because of unstable angina pectoris. Coronary angiography revealed severe stenosis at a proximal site of the left anterior descending artery. Essential thrombocythemia (ET) was diagnosed on the basis of findings of marked thrombocytosis (106 x 10(4)/microL) and an increased number of immature megakaryocytes in the bone marrow. Because hyperaggregability of platelets was demonstrated by an ex vivo platelet aggregation assay and by elevated plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4), antiplatelet therapy with aspirin and ticlopidine and cytoreduction therapy with hydroxyurea were started. This combination treatment resulted in a decrease in the platelet count to less than 60 x 10(4)/microL and decreases in plasma levels of both beta-TG and PF4 to almost normal values. Percutaneous coronary angioplasty and stenting were then performed successfully without thrombotic complications. These findings suggest that combination therapy with antiplatelet and cytoreduction agents before catheter intervention is useful for the prevention of thrombotic complications in patients with acute coronary syndrome associated with essential thrombocythemia.
(キーワード): Acute Disease / Angina, Unstable / Aspirin / Combined Modality Therapy / Coronary Stenosis / Humans / Hydroxyurea / Male / Middle Aged / Platelet Aggregation Inhibitors / Stents / Thrombocythemia, Essential / Ticlopidine
(出版サイトへのリンク): ● Publication site (DOI): 10.1177/000331970305400414
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12934770; ● Search Scopus @ Elsevier (PMID): 12934770; ● Search Scopus @ Elsevier (DOI): 10.1177/000331970305400414

(DOI: 10.1177/000331970305400414, PubMed: 12934770) Scott J. Cameron, Sundeep Malik, Masashi Akaike, Nicole Lerner-Marmarosh, Chen Yan, Jiing-Dwan Lee, Jun-ichi Abe and Jay Yang :
Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase 1/ERK5 but Not ERK1/2 Kinase Activation,
The Journal of Biological Chemistry, Vol.278, No.20, 18682-18688, 2003.

(要約): The gap junction protein, Cx43, plays a pivotal role in coupling cells electrically and metabolically, and the putative phosphorylation sites that modulate its function are reflected as changes in gap junction communication. Growth factor stimulation has been correlated with a decrease in gap junction communication and a parallel activation of ERK1/2; the inhibition of epidermal growth factor (EGF)-induced Cx43 gap junction uncoupling was observed by using the MEK1/2 inhibitor, PD98059. Because 1) BMK1/ERK5, another MAPK family member also activated by growth factors, possesses a phosphorylation motif similar to ERK1/2, and 2) it has been reported that PD98059 can inhibit not only MEK1/2-ERK1/2 but also MEK5-BMK1 activation, we investigated whether BMK1 can regulate EGF-induced Cx43 gap junction uncoupling and phosphorylation, comparing this to the role of ERK1/2 on Cx43 function and phosphorylation induced by EGF. Selective activation or inactivation of ERK1/2 by using a constitutively active form or a dominant negative form of MEK1 did not regulate Cx43 gap junction coupling. In contrast, we found that BMK1, selectively activated by constitutively active MEK5alpha, induced gap junction uncoupling, and the inhibition of BMK1 activation by transfection of dominant negative BMK1 prevented EGF-induced gap junction uncoupling. Activated BMK1 selectively phosphorylates Cx43 on Ser-255 in vitro and in vivo, but not on S279/S282, which are reported as the consensus phosphorylation sites for MAPK. Furthermore, by co-immunoprecipitation, we found that BMK1 directly associates with Cx43 in vivo. These data indicate that BMK1 is more important than ERK1/2 in EGF-mediated Cx43 gap junction uncoupling by association and Cx43 Ser- 255 phosphorylation.
(キーワード): Blotting, Western / Cell Line / Connexin 43 / Enzyme Activation / Enzyme Inhibitors / Epidermal Growth Factor / Flavonoids / Gap Junctions / Genes, Dominant / Humans / Immunoblotting / MAP Kinase Kinase 1 / MAP Kinase Signaling System / Microscopy, Fluorescence / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Mitogen-Activated Protein Kinase 7 / Mitogen-Activated Protein Kinase Kinases / Mitogen-Activated Protein Kinases / Phosphorylation / Precipitin Tests / Protein Structure, Tertiary / Protein-Serine-Threonine Kinases / Serine / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Transfection
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M213283200
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12637502; ● Search Scopus @ Elsevier (PMID): 12637502; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M213283200

(DOI: 10.1074/jbc.M213283200, PubMed: 12637502) Takahiko Iuchi, Masashi Akaike, Takao Mitsui, Yasushi Ohshima, Yasumi Shintani, Hiroyuki Azuma and Toshio Matsumoto :
Glucocorticoid Excess Induces Superoxide Production in Vascular Endothelial Cells and Elicits Vascular Endothelial Dysfunction,
Circulation Research, Vol.92, No.1, 81-87, 2003.

(要約): Glucocorticoid (GC) excess often elicits serious adverse effects on the vascular system, such as hypertension and atherosclerosis, and effective prophylaxis for these complications is limited. We sought to reveal the mechanism underlying GC-induced vascular complications. Responses in forearm blood flow to reactive hyperemia in 20 GC-treated patients were significantly decreased to 43+/-8.9% (mean+/-SEM) from the values obtained before GC therapy (130+/-14%). An administration of vitamin C almost normalized blood flow responses. In human umbilical vein endothelial cells (HUVECs), production of hydrogen peroxide was increased up to 166.5+/-3.3% of control values by 10(-7) mol/L dexamethasone (DEX) treatment (P<0.01). Concomitant with DEX-induced hydrogen peroxide production, intracellular amounts of peroxynitrite significantly increased and those of nitric oxide (NO) decreased, respectively (P<0.01). Immunoblotting analysis using anti-nitrotyrosine antibody showed that peroxynitrite formation was increased in DEX-treated HUVECs. Using inhibitors against metabolic pathways for generation of reactive oxygen species (ROS), we identified that the major production sources of ROS by DEX treatment were mitochondrial electron transport chain, NAD(P)H oxidase, and xanthine oxidase. These findings suggest that GC excess causes overproduction of ROS and thereby perturbs NO availability in the vascular endothelium, leading to vascular complications in patients with GC excess.
(キーワード): Glucocorticoid / reactive oxygen species / nitric oxide / vascular endothelial function
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.RES.0000050588.35034.3C
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12522124; ● Search Scopus @ Elsevier (PMID): 12522124; ● Search Scopus @ Elsevier (DOI): 10.1161/01.RES.0000050588.35034.3C

(DOI: 10.1161/01.RES.0000050588.35034.3C, PubMed: 12522124) Masashi Akaike, Hiroyuki Azuma, Ayako Kagawa, Kazuya Matsumoto, Ikuro Hayashi, Katsuya Tamura, Takeshi Nishiuchi, Takahiko Iuchi, Nobuyuki Takamori, Ken-ichi Aihara, Tomonori Yoshida, Yasuhiko Kanagawa and Toshio Matsumoto :
Effect of Aspirin Treatment on Serum Concentrations of Lipoprotein(a) in Patients with Atherosclerotic Diseases,
Clinical Chemistry, Vol.48, No.9, 1454-1459, 2002.

(要約): Increased serum lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerosis. We previously reported that aspirin reduced Lp(a) production by cultured hepatocytes via the reduction of apolipoprotein(a) [apo(a)] gene transcription. We evaluated both the effect of aspirin treatment (81 mg/day) on serum Lp(a) concentrations and the correlation between the degree of reduction in serum Lp(a) and the type of apo(a) isoform in 70 patients with coronary artery disease or cerebral infarction. Aspirin lowered serum Lp(a) concentrations to approximately 80% of the baseline values in patients with high Lp(a) concentrations (>300 mg/L). The percentage of decrease in serum Lp(a) was larger in patients with high Lp(a) than in patients with low Lp(a) (<300 mg/L), irrespective of apo(a) isoform size. The decreases in serum Lp(a) in high Lp(a) patients with both the high-molecular-weight and the low-molecular-weight isoforms were positively correlated with the baseline Lp(a) concentrations. Because the secretory efficiencies of apo(a) in the same isoform are likely to be similar, the difference in serum Lp(a) concentrations in patients having the same apo(a) isoform depends on the transcriptional activity of the apo(a) gene. These findings suggest that aspirin decreases serum Lp(a) concentrations via a decrease in apo(a) gene transcription more effectively in patients with high transcriptional activity of this gene.
(キーワード): Arteriosclerosis / Aspirin / Cerebral Infarction / Coronary Disease / Female / Humans / Hypolipidemic Agents / Lipoprotein(a) / Male / Middle Aged / Protein Isoforms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12194922; ● Search Scopus @ Elsevier (PMID): 12194922

(PubMed: 12194922) Takao Mitsui, Yoshifumi Umaki, Masakazu Nagasawa, Masashi Akaike, Kenji Aki, Hiroyuki Azuma, Shuji Ozaki, Masaaki Odomi and Toshio Matsumoto :
Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease,
Acta Neuropathologica, Vol.104, No.3, 260-266, 2002.

(要約): Two patients with long-term corticosteroid administration sporadically developed limb muscle wasting followed by ophthalmoplegia, and the skeletal muscle pathology revealed ragged-red fibers (RRFs) with abnormal mitochondria, in addition to the findings of corticosteroid myopathy. The oculoskeletal symptoms of the present cases resemble those of chronic progressive external ophthalmoplegia, a type of mitochondrial disease. The ocular muscles have more RRFs than limb muscles, and large multiple deletions of mitochondrial DNA was detected in ocular and limb muscles of the two patients by PCR but not by Southern blotting. Immunohistochemistry demonstrated that 8-hydroxy-deoxyguanosine (8-OH-dG) and 4-hydroxy-2-nonenal were intensely stained in skeletal muscles of these patients particularly in RRFs. High-performance liquid chromatography with electrochemical detection analysis revealed an increase in 8-OH-dG from mitochondrial DNA. These findings may suggest that long-term corticosteroid administration potentially induces oxidative stress-mediated mitochondrial damage, resulting in the development of the oculoskeletal symptoms in some patients.
(キーワード): Aldehydes / Anti-Inflammatory Agents / Deoxyguanosine / Diagnosis, Differential / Exercise Test / Female / Gene Deletion / Humans / Lactic Acid / Male / Middle Aged / Mitochondria, Muscle / Oculomotor Muscles / Ophthalmoplegia, Chronic Progressive External / Prednisolone / Superoxide Dismutase / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00401-002-0553-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12172911; ● Search Scopus @ Elsevier (PMID): 12172911; ● Search Scopus @ Elsevier (DOI): 10.1007/s00401-002-0553-5

(DOI: 10.1007/s00401-002-0553-5, PubMed: 12172911) Takao Mitsui, Hiroyuki Azuma, Masakazu Nagasawa, Takahiko Iuchi, Masashi Akaike, Masaaki Odomi and Toshio Matsumoto :
Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle,
Journal of Neurology, Vol.249, No.8, 1004-1009, 2002.

(要約): Corticosteroid myopathy is a major clinical problem in patients undergoing chronic corticosteroid treatment and shows insidious and progressive muscle atrophy in proximal limbs. Although several mechanisms underlying the pathophysiology of muscle injury have been postulated, precise pathogenesis is still not clear. We evaluated the mitochondrial functions in patients receiving corticosteroids compared with those in healthy controls or patients not receiving corticosteroids. The serum levels and total production of lactate were investigated by an aerobic exercise test using a bicycle ergometer. Mitochondrial respiratory activities and oxidative damage in biopsied skeletal muscles were also studied. The results of aerobic exercise tests revealed a significant overproduction of lactate in patients treated with corticosteroids ( p < 0.005), which was positively correlated with total corticosteroid doses administered ( p < 0.0001). In these patients, mitochondrial enzyme activity in complex I was significantly decreased ( p < 0.05) and oxidative damage of biopsied skeletal muscle was remarkable both in mitochondrial and nuclear DNAs ( p < 0.001). The results suggest that chronic corticosteroid administration induces mitochondrial dysfunction and oxidative damage in skeletal muscles, which may be the pathogenesis, at least in part, of corticosteroid-induced myopathy.
(キーワード): Corticosteroid myopathy / Mitochondrial respiratory activity / oxidative damage / aerobic exercise / biopsied skeletal muscle
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00415-002-0774-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12195445; ● Search Scopus @ Elsevier (PMID): 12195445; ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-002-0774-5

(DOI: 10.1007/s00415-002-0774-5, PubMed: 12195445) Yoshifumi Umaki, Takao Mitsui, Itsuro Endo, Masashi Akaike and Toshio Matsumoto :
Apoptosis-related changes in skeletal muscle of patients with mitochondreal disease.,
Acta Neuropathologica, Vol.103, No.2, 163-170, 2002.

(要約): Much interest has recently been shown in apoptosis-mediated roles in the pathophysiology of mitochondrial diseases, because mitochondrial defects are implicated in a wide variety of degenerative diseases. We investigated whether apoptotic events occurred in skeletal muscles of patients with mitochondrial diseases, including chronic progressive external ophthalmoplegia (CPEO), Kearns-Sayer syndrome (KSS), and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). In a immunohistochemical study, stainings for 8-hydroxy-deoxyguanosine (8-OH-dG), 4-hydroxy-nonenal (4-HNE), Mn-SOD, Bcl-2, cytochrome c, DNase I and Bcl-x L showed a pronounced granular distribution in the cytochrome c oxidase (COX)-negative ragged-red fibers (RRFs). On the other hand, the signals for Bax, p53, Fas and caspase 3 were not obviously increased in RRFs. In situ labeling of DNA breaks demonstrated preferential signals not only in myonuclei but also in subsarcolemmal regions of RRFs, indicating that mitochondrial as well as myonuclear DNA is fragmented in RRFs. An immunoblotting study demonstrated that cytochrome c was increased in the cytosol of diseased muscles and that DNase I was increased in mitochondria, compared to that of normal muscles. No difference was observed between protein bands at 20 kDa corresponding to caspase 3 in diseased and normal muscles. These findings demonstrate that these mitochondrial diseases harbor unique apoptosis-related changes that differ from caspase 3-dependent apoptosis. It is thought that these changes are induced by superoxide overproduction and cytochrome c release resulting from an inherent mitochondrial defect and that the events are associated with DNase I activation.
(キーワード): mitochondrial diseases / skeletal muscles
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s004010100446
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11810183; ● Search Scopus @ Elsevier (PMID): 11810183; ● Search Scopus @ Elsevier (DOI): 10.1007/s004010100446

(DOI: 10.1007/s004010100446, PubMed: 11810183) Y Kuroda, Takao Mitsui, Masashi Akaike, Hiroyuki Azuma and Toshio Matsumoto :
Homozygous deletion mutation of the parkin gene in patients with atypical parkinsonism,
Journal of Neurology, Neurosurgery, and Psychiatry, Vol.71, No.2, 231-234, 2001.

(要約): Autosomal recessive juvenile parkinsonism (AR-JP) is characterised by homogenous clinical features and selective degeneration of nigral neurons. Recent progress in molecular genetic analyses of AR-JP has led to the identification of a novel ubiquitin-like protein, parkin, whose precise function still remains to be elucidated. Two unrelated Japanese families had levodopa unresponsive parkinsonism complicated with cerebellar and pyramidal tract dysfunction. Genetic analysis of the parkin gene and mRNA in both families disclosed identical mutations with large deletions extending from exons 3 to 4. These results suggest that the parkin protein possesses an important function not only in the substantia nigra but also in extranigral neurons of the CNS and that the phenotype of multiple system dysfunction can also be a complication in patients with AR-JP due to variations in sites of or changes in functions by parkin mutation.
(キーワード): AR-JP / parkin / multiple system degeneration / deletion mutation
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/jnnp.71.2.231
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11459900; ● Search Scopus @ Elsevier (PMID): 11459900; ● Search Scopus @ Elsevier (DOI): 10.1136/jnnp.71.2.231

(DOI: 10.1136/jnnp.71.2.231, PubMed: 11459900) Ken-ichi Aihara, Hiroyuki Azuma, Yasumasa Ikeda, Masashi Akaike, Masahiro Abe, Takashi Sugihara and Toshio Matsumoto :
Successful combination therapy--flunarizine,pentoxifylline, and cholestyramine--for spur cell anemia,
International Journal of Hematology, Vol.73, No.3, 351-355, 2001.

(要約): Spur cell anemia, a hemolytic anemia observed in patients with alcoholic cirrhosis, is characterized by unusual erythrocyte morphology and an increased ratio of free cholesterol to phospholipid in the erythrocyte membrane. The prognosis of spur cell anemia is usually extremely poor, however, we describe here a patient with spur cell anemia who was successfully treated with combination therapy consisting of flunarizine, pentoxifylline, and cholestyramine. Initial therapy with flunarizine alone for 6 weeks did not significantly decrease the number of spur cells on peripheral blood smears. So pentoxifylline was added to the regimen. The patient recovered from the anemia, showed remarkable improvement with regard to the hyperbilirubinemia, and the changes were accompanied by a significant decrease in the number of spur cells in peripheral blood smears. To correct the hypercholesterolemia, cholestyramine was added to the regimen, which resulted in a reduction in the serum level of free cholesterol and an increase in the molar ratio of free cholesterol to phospholipid in erythrocyte membrane. However, 6 months later a skin eruption developed that was considered an adverse reaction to the drugs, so the flunarizine and pentoxifylline were discontinued. With cholestyramine therapy alone, the remission of spur cell anemia was maintained for more than 11 months. These observations suggest that non-invasive combination therapy with flunarizine, pentoxifylline, and cholestyramine is effective and valuable in the treatment of patients with spur cell anemia.
(キーワード): Spur cell anemia / Free cholesterol / Hepatosplenomegaly / Pentoxifylline / Cholestyramine
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11345202; ● Search Scopus @ Elsevier (PMID): 11345202

(PubMed: 11345202) Yasuhiko Kanagawa, Toshio Shigekiyo, Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma and Toshio Matsumoto :
Molecular mechanism of type I congenital heparin cofactor (HC) II deficiency caused by a missense mutation at reactive P2 site: HC II Tokushima,
Thrombosis and Haemostasis, Vol.85, No.1, 101-107, 2001.

(要約): We found a 66-year-old Japanese patient with type I congenital heparin cofactor (HC) II deficiency manifesting multiple atherosclerotic lesions. To investigate the molecular pathogenesis of our patient, we performed sequencing analysis and expressed recombinant human wild-type and mutant HC II molecules in COS-1 and CHO-K1 cells. Sequencing analysis following amplification of each of all 5 exons and its flanking region showed a single C to T transition at nucleotide position 12,854 in exon 5, which changed a Pro443 codon (CCG) to Leu codon (CTG). Because this mutation generates a new Bhv I site, the Bbv I digestion pattern of the PCR-amplified exon 5 fragments from each family member was analyzed. In all cases, the patterns were consistent with the activities and antigen levels of plasma HC I1 in those members. Transient transfection, metabolic labeling and pulse-chase experiments followed by immunoprecipitation analysis showed that the recombinant mutant HC II molecules were secreted from COS-1 cells in reduced amounts compared with the wild-type, and that an enhanced intracellular association of the mutant molecules with a chaperone, GRP78/BiP, was observed in CHO-K1 cells. Northern blot analysis indicated that the mutant HC I1 mRNA was transcribed at a similar level as that of wild-type. Immunohistochemical staining of the transfected cells revealed that COS-1 cells expressing the mutant HC II molecules were stained mainly in the perinuclear area. We conclude that the impaired secretion of the mutant HC II molecules, due to intracellular degradation, is the molecular pathogenesis of type I congenital HC II deficiency caused by a Pro443 to Leu mutation at reactive P2 site.
(キーワード): heparin cofactor II / thrombosis / thrombin / transfection / chaperone
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11204559; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035171975

(PubMed: 11204559, Elsevier: Scopus) 赤池雅史, 井内貴彦, 加藤みどり, 吉田智則, 橋詰俊二, 高森信行, 藤村光則, 金川泰彦, 東博之, 松本俊夫 :
冠動脈疾患の予防ならびに治療の観点からみた高コレステロール血症治療の現状とその問題点, --- 四国高脂血症スタディ ---,
診断と治療, Vol.89, No.3, 527-532, 2001年.

(キーワード): 冠動脈疾患 / 高コレステロール血症 / 一次予防 / 二次予防 / 高脂血症診療ガイドライン

足立克仁, 木村千代美, 齋藤美穂, 上田由利子, 乾俊夫, 国重誠, 馬木良文, 赤池雅史, 川井尚臣 :
悪性肢帯型筋ジストロフィー(三好)患者におけるサリコグリカンの遺伝子異常ならびに臨床像と剖検心所見,
医療, Vol.54, No.9, 419-423, 2000年.

(キーワード): サルコグリカノパチー / 遺伝子異常 / 悪性肢帯型筋ジストロフィー / 心所見
(出版サイトへのリンク): ● Publication site (DOI): 10.11261/iryo1946.54.419
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.11261/iryo1946.54.419

(DOI: 10.11261/iryo1946.54.419) Takao Mitsui, Masakazu Kawajiri, Makoto Kunishige, Takenori Endo, Masashi Akaike, Kenji Aki and Toshio Matsumoto :
Functional association between nicotinic acetylcholine receptor and sarcomeric proteins via actin and desmin filaments,
Journal of Cellular Biochemistry, Vol.77, No.4, 584-595, 2000.

(キーワード): acetylcholine receptor / sarcomeric protein / actin / desmin / ATPase

Ayako Kagawa, Hiroyuki Azuma, Masashi Akaike, Yasuhiko Kanagawa and Toshio Matsumoto :
Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription,
The Journal of Biological Chemistry, Vol.274, No.48, 34111-34115, 1999.

(要約): High serum lipoprotein(a) (Lp(a)) is a risk factor for vascular disorders. Our preliminary observations suggest that, in some patients with coronary heart disease with high serum Lp(a) levels, administration of aspirin reduced Lp(a) levels. Therefore, we aimed to analyze the effects of aspirin on the production of apo(a), the expression of apolipoprotein(a) (apo(a)) mRNA and the transcriptional activity of apo(a) gene promoter. Aspirin (5 mM) reduced the apo(a) levels in culture medium of human hepatocytes and suppressed apo(a) mRNA expression to 73% and 85% of the controls, respectively. Aspirin also reduced the transcriptional activity of apo(a) gene transfected into HepG2 hepatoma cells in a dose-dependent manner, with a maximal effect at 5 mM (44.3 +/- 1.5% of the control). Sodium salicylate (5 mM) also reduced apo(a) gene transcription, whereas indomethacin (10 microM) had no effect. Deletion analysis of apo(a) gene promoter showed that promoter region extending from -30 to +138 is critical for the effect of aspirin. Furthermore, enhanced production, mRNA expression, and gene transcription of apo(a) by interleukin-6 were also inhibited by aspirin. These results demonstrate that aspirin reduces apo(a) production from hepatocytes via reduction of the transcriptional activity of apo(a) gene with suppression of apo(a) mRNA expression. The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.
(キーワード): Apolipoproteins A / Aspirin / Gene Expression Regulation / Humans / Indomethacin / Interleukin-6 / Liver / Luciferases / Promoter Regions, Genetic / RNA, Messenger / Recombinant Fusion Proteins / Sodium Salicylate / Transcription, Genetic / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.274.48.34111
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10567380; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033607536

(DOI: 10.1074/jbc.274.48.34111, PubMed: 10567380, Elsevier: Scopus) 赤池雅史, 東博之, 香川礼香, 金川泰彦, 粟飯原賢一, 松山まどか, 井内貴彦, 高森信行, 吉田智則, 松本俊夫, 松本和也, 林郁郎, 田村克也, 西内健 :
高リポ蛋白(a)血症に及ぼすaspirinの影響, --- アポリポ蛋白(a)アイソフォームとの関連 ---,
四国医学雑誌, Vol.55, No.3, 109-114, 1999年.

(キーワード): Lipoprotein(a) / Apolipoprotein(a) / Aspirin / Apo(a)Isoform / Lp(a) Phenotype
(徳島大学機関リポジトリ): ● Metadata: 112143

(徳島大学機関リポジトリ: 112143) Hisaomi Kawai, Masashi Akaike, Makoto Kunishige, Toshio Inui, Katsuhito Adachi, Chiyomi Kimura, Masakazu Kawajiri, Yoshihiko Nishida, Itsuro Endo, Setsuko Kashiwagi, Hiroshi Nishino, Tsutomu Fujiwara, Shiro Okuno, Carinne Roudaut, Isabelle Richard, Jacques S. Beckmann, Kazuo Miyoshi and Toshio Matsumoto :
Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families,
Muscle & Nerve, Vol.21, No.11, 1493-1501, 1998.

(要約): We report on the clinical, pathological, and genetic features of 7 patients with limb-girdle muscular dystrophy type 2A (LGMD2A) from three Japanese families. The mean age of onset was 9.7+/-3.1 years (mean+/-SD), and loss of ambulance occurred at 38.5+/-2.1 years. Muscle atrophy was predominant in the pelvic and shoulder girdles, and proximal limb muscles. Muscle pathology revealed dystrophic changes. In two families, an identical G to C mutation at position 1080 the in calpain 3 gene was identified, and a frameshift mutation (1796insA) was found in the third family. The former mutation results in a W360R substitution in the proteolytic site of calpain 3, and the latter in a deletion of the Ca2+-binding domain.
(キーワード): limb-girdle muscular dystrophy type 2A / calpain 3 gene / mutation / プロテアーゼ (protease) / clinical feature / pathology
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/(SICI)1097-4598(199811)21:11<1493::AID-MUS19>3.0.CO;2-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9771675; ● Search Scopus @ Elsevier (PMID): 9771675; ● Search Scopus @ Elsevier (DOI): 10.1002/(SICI)1097-4598(199811)21:11<1493::AID-MUS19>3.0.CO;2-1

(DOI: 10.1002/(SICI)1097-4598(199811)21:11<1493::AID-MUS19>3.0.CO;2-1, PubMed: 9771675) K Fukuhara, Y Urano, Masashi Akaike, K Ahsan and S Arase :
Psoriatic arthritis associated with dilated cardiomyopathy and Takayasu's arteritis,
The British Journal of Dermatology, Vol.138, No.2, 329-333, 1998.

(要約): A 40-year-old Japanese man with psoriatic arthritis (PA) involving the spine, sacroiliac and peripheral joints presented with dyspnoea and ankle oedema. Blood pressure was 180/110 and 114/80 mmHg in the right and left upper arms, respectively. Examinations showed left ventricular dilatation and diffuse hypokinesis of the left ventricle, with no involvement of the coronary arteries. Aortography detected total occlusion of the left subclavian artery and stenosis of the origin at the right renal artery. Dilated cardiomyopathy and Takayasu's arteritis associated with PA was diagnosed. A few cases of PA have been reported in association with cardiovascular diseases, but the association of these three diseases has not been documented in the literature to date. Dermatologists need to be aware of cardiovascular manifestations in patients with PA, because cardiovascular diseases are not rare in other seronegative spondyloarthropathies.
(キーワード): Adult / Aortography / Arthritis, Psoriatic / Cardiomyopathy, Dilated / Echocardiography / Humans / Male / Takayasu Arteritis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9602885; ● Search Scopus @ Elsevier (PMID): 9602885

(PubMed: 9602885) Ktsuhito Adachi, Hisaomi Kawai, Miho Saito, Takako Naruo, Chiyomi Kimura, Hideki Mine, Toshio Inui, Setsuko Kashiwagi and Masashi Akaike :
Plasma levels of brain natriuretic peptide as an index for evaluation of cardiac function in female gene carriers of Duchenne muscular dystrophy,
Internal Medicine, Vol.36, No.7, 497-500, 1997.

(キーワード): Duchenne muscular dystrophy(DMD) / female gene carrier / brain natriuretic peptide(BNP) / Atrial Natriuretic Peptide(ANP) / cardiac failure

Masashi Akaike, Hisaomi Kawai, Kenji Yokoi, Makoto Kunishige, Hideki Mine, Yoshihiko Nishida and Shiro Saito :
Cardiac dysfunction in patients with chronic progressive external ophthalmoplegia,
Clinical Cardiology, Vol.20, No.3, 239-243, 1997.

(キーワード): chronic progressive external ophthalmoplegia / mitochondrial myopathy / Cardiac dysfunction

峯秀樹, 川井尚臣, 赤池雅史, 国重誠, 柏木節子, 馬木良文, 仁木伸二, 川井恵子, 齋藤史郎 :
多腺性自己免疫症候群3型に強皮症を合併したHTLV-1キャリアの1例,
ホルモンと臨床, Vol.45, 93-97, 1997年. 足立克仁, 川井尚臣, 齋藤美穂, 柏木節子, 赤池雅史 :
Duchenne型筋ジストロフィー女性保因者における不顕性の心障害,
神経内科, Vol.46, 253-258, 1997年.

(キーワード): Duchenne Muscular Dystrophy / Female Gene Carrier / Brain Natriuretic Peptide / Cardiac Dysfunction

N Matsumoto, Masashi Akaike, Takeshi Nishiuchi, Hisaomi Kawai and Shiro Saito :
Different secretion profiles of atrial and brain natriuretic peptides after acute volume loading in patients with ischemic heart disease,
Acta Cardiologica, Vol.52, No.3, 261-272, 1997.

(要約): In order to clarify the different secretion profiles of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in response to acute hemodynamic change by volume expansion, we measured plasma ANP and BNP levels after intravenous isotonic saline infusion for 3 min at a rate of 3 ml/kg body weight/min in 15 patients with ischemic heart disease. Plasma ANP and BNP levels before the volume loading were 30.7 +/- 16.7 and 19.4 +/- 24.6 pg/ml, respectively. Five and 10 minutes after infusion, plasma ANP levels rose significantly to 43.5 +/- 20.7 and to 46.0 +/- 22.5 pg/ml, respectively (p < 0.01), and plasma BNP levels rose significantly to 27.3 +/- 30.8 and 24.8 +/- 23.2 pg/ ml, respectively (p < 0.01). The BNP/ANP ratio was not affected by volume loading. The maximum increments of plasma ANP level correlated significantly with those of the mean pulmonary capillary wedge pressure (mPCWP, r = 0.78, p < 0.01) or left ventricular end-diastolic pressure (LVEDP, r = 0.86, p < 0.01). However, there were no significant correlations between the maximum increments of plasma BNP levels and those of mPCWP or LVEDP. Plasma ANP level can be a useful parameter for atrial pressure even if the hemodynamic state change rapidly. However, in an early phase of ventricular overload BNP secretion is not increased sufficiently despite the raised LVEDP, and plasma BNP level may not always reflect ventricular hemodynamics.
(キーワード): Atrial Natriuretic Factor / Hemodynamics / Humans / Male / Middle Aged / Myocardial Ischemia / Natriuretic Peptide, Brain / Nerve Tissue Proteins / Sodium Chloride
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9217917; ● Search Scopus @ Elsevier (PMID): 9217917

(PubMed: 9217917) Kazue Yamabe, Masashi Akaike, Michihisa Kato, Fumihiko Tada, Hirotsugu Yamada, Tomoko Arase and Arifumi Kohyama :
The efficacy of inhaled nitic oxide in a patient with acute massive pulmonary thromboembolism.,
Journal of the Japanese Society of Intensive Care Medicine, Vol.3, No.4, 283-287, 1996. Miho Saito, Hisaomi Kawai, Masashi Akaike, Katsuhito Adachi, Yoshihiko Nishida and Shiro Saito :
Cardiac Dysfunction with Becker Muscular Dystrophy,
American Heart Journal, Vol.132, No.3, 642-647, 1996. Hideki Mine, Hisaomi Kawai, Kenji Yokoi, Masashi Akaike and Shiro Saito :
High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies,
Journal of Molecular Medicine, Vol.74, No.8, 471-477, 1996.

(要約): To investigate the relationship between human T-lymphotropic virus (HTLV) types I and II and the pathogenesis of autoimmune thyroid diseases, we examined serum anti-thyroid antibodies in 1019 blood donors with or without serum anti-HTLV-I antibody as well as proviral DNA for HTLV-II in leukocyte DNA by the polymerase chain reaction in 395 blood donors with or without anti-thyroid antibodies. The frequency of donors with anti-HTLV-I antibody who also showed anti-thyroid antibodies (7.9%) tended to be higher than that (6.3%) among donors who did not have the anti-HTLV-I antibody. The frequency of anti-thyroid antibodies in 125 young male donors aged 16-39 years with anti-HTLV-I antibody (4.8%) was significantly higher (P < 0.05) than that (0.6%) in 164 control donors without the antibody. In blood donors with anti-thyroid antibody, 25.0% of those with anti-HTLV-I antibody and 14.3% of those without the antibody had HTLV-II proviral DNA. In contrast, in donors without anti-thyroid antibody HTLV-II proviral DNA was detected in 2.3% of those with anti-HTLV-I antibody and in 0.6% of those without the antibody. Thus the detection rates in donors with anti-thyroid antibody were significantly higher (P < 0.001) than those in donors without the antibody, regardless of HTLV-I infection. These results suggest that HTLV-I infection and the presence of HTLV-II proviral DNA may be independently related to the pathogenesis of autoimmune thyroid diseases.
(キーワード): Human T-lymphotropic virus type I / Human T-lymphotropic virus type II / Retrovirus / Autoimmune thyroid diseases
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8872861; ● Summary page in Scopus @ Elsevier: 2-s2.0-0029764409

(PubMed: 8872861, Elsevier: Scopus) 川井尚臣, 横井健治, 峯秀樹, 川尻真和, 西田善彦, 斎藤史郎, 赤池雅史 :
自己免疫性甲状腺疾患の発病とHTL-2との関係について, --- 自己免疫性甲状腺疾患には白血球DNA中にHTLV-2関連プロウイルスDNAを有する患者が高頻度に存在する ---,
日本医事新報, Vol.3768, 37-42, 1996年. Takao Mitsui, Hisaomi Kawai, Masakazu Nagasawa, Makoto Kunishige, Masashi Akaike, Yuzo Kimura and Shiro Saito :
Oxidative damage to skeletal muscle DNA from patients with mitochondrial encephalomyopathies,
Journal of the Neurological Sciences, Vol.139, No.1, 111-116, 1996. Hisaomi Kawai, Takao Mitsui, Kenji Yokoi, Masashi Akaike, K Hirose, K Hizawa and S Saito :
Evidence of HTLV-I in thyroid tissue in an HTLV-I carrier with Hashimoto's thyroiditis,
Journal of molecular medicine, Vol.74, No.5, 275-278, 1996.

(キーワード): Human T-lymphotropic virus type l / Hashimoto's thyroiditis / envelope protein / messenger RNA / in situ hybridization

遠藤武徳, 赤池雅史, 川井尚臣, 松村喜一郎, 齋藤史郎 :
悪性肢帯型筋ジストロフィーにみられたadhalin遺伝子の異常とadhalin欠損筋ジストロフィーにおける臨床像の特徴,
臨床神経学, Vol.36, No.3, 415-422, 1996年.

(キーワード): 悪性肢帯型筋ジストロフィー / 常染色体劣性遺伝 / adhalin欠損症 / adhalin遺伝子異常

M. Kunishige, Takao Mitsui, Masashi Akaike, Masayuki Shono, H. Kawai and Shiro Saito :
Localization and amount of myoglobin and myoglobin mRNA in ragged-red fiber of patients with mitochondrial encephalomyopathy.,
Muscle-Nerve., Vol.19, No.2, 79-86, 1996.

(キーワード): myoglobin / ミトコンドリア (mitochondria)

Makoto Kunishige, Takao Mitsui, Masashi Akaike, Masayuki Shono, Hisaomi Kawai and Shiro Saito :
Localization and amount of myoglobin and myoglobin mRNA in ragged-red fiber of patients with mitochondrial encephalomyopathy,
Muscle & nerve, Vol.19, No.2, 175-182, 1996.

(キーワード): myoglobin / myoglobin mRNA / in situ hybridization / ragged-red fiber / mitochondrial encephalomyopathy

柏木節子, 赤池雅史, 川井尚臣, 足立克仁, 斎藤史郎 :
Duchenne型筋ジストロフィーにおける心機能の血漿脳性ナトリウム利尿ペプチド濃度による評価,
臨床神経学, Vol.36, No.1, 7-11, 1996年.

(キーワード): Duchenne型筋ジストロフィー / 脳性ナトリウム利尿ペプチド(BNP) / 血漿BNP濃度 / 心不全 (cardiac failure)

Yukiko Kuroda, Takao Mitsui, Makoto Kunishige, M Shono, Masashi Akaike, Hiroyuki Azuma and Toshio Matsumoto :
Parkin enhances mitochondrial biogenesis in proliferating cells,
Hum Mol Genet, Vol.15, No.6, 883-895, 1996. 山部一恵, 赤池雅史, 加藤道久, 多田文彦, 山田博胤, 荒瀬友子, 神山有史 :
一酸化窒素吸入療法が有効であった急性広汎型血栓塞栓症の1例,
日本集中治療学会雑誌, Vol.3(4), 283-288, 1996年. 市原寿江, 美馬伸章, 赤池雅史, 東博之, 重清俊雄, 斎藤史郎 :
播種性血管内血液凝固症候群を合併した孤立性腸骨動脈瘤の1例,
日本老年医学会雑誌, Vol.32, No.12, 822-824, 1995年. Hisaomi Kawai, Masashi Akaike, Takenori Endo, Katsuhito Abachi, Takao Mitsui, Setsuko Kashiwagi, Ysutomu Fujiwara, Shiro Okuno, Sadahito Shin, Kazuo Miyoshi, Kevin P Campbell, Hiroki Yamada, Shimizu Teruo, Kiichiro Matsumura and Shiro Saito :
Adhalin Gene Mutations in Patients with Autosomal Recessive Childhood Onset Muscular Dystrophy with Adhalin Deficiency,
The Journal of Clinical Investigation, Vol.96, No.3, 1202-1207, 1995.

(要約): Homozygous adhalin gene mutations were found in three patients from two consanguineous families with autosomal recessive childhood onset muscular dystrophy. Muscle biopsies from patients in each family showed complete absence of adhalin. Sequencing of adhalin cDNA prepared from skeletal muscle by reverse transcription PCR demonstrated a cytosine to thymidine substitution at nt 229 in the patient in family 1 and an adenine to guanine substitution at nt 410 and a 15-base insertion between nt 408 and 409 in the two patients in family 2. Sequencing of genomic DNA prepared from peripheral blood leukocytes by PCR confirmed these mutations. The parents in each family were found to be heterozygous for the respective mutations. These adhalin gene mutations are presumed to be responsible for the absence of adhalin in the skeletal muscle. Adhalin deficiency likely causes disruption of the muscle cell membrane, resulting in dystrophic changes in the skeletal muscle similar to dystrophin deficiency in Duchenne muscular dystrophy.
(キーワード): Adult / Age of Onset / Amino Acid Sequence / Base Sequence / Biopsy / Child / Consanguinity / Cytoskeletal Proteins / DNA Primers / DNA Transposable Elements / DNA, Complementary / Female / Genes, Recessive / Homozygote / Humans / Immunohistochemistry / Male / Membrane Glycoproteins / Middle Aged / Molecular Sequence Data / Muscle, Skeletal / Muscular Dystrophies / Mutation / Pedigree / Polymerase Chain Reaction / Reference Values / Sarcoglycans
(出版サイトへのリンク): ● Publication site (DOI): 10.1172/JCI118152
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7657792; ● Search Scopus @ Elsevier (PMID): 7657792; ● Search Scopus @ Elsevier (DOI): 10.1172/JCI118152

(DOI: 10.1172/JCI118152, PubMed: 7657792) 横井健治, 赤池雅史, 重清俊雄 :
抗リン脂質抗体が陽性であった高齢者多発性脳梗塞の2例,
内科専門医会誌, Vol.7, No.3, 236-239, 1995年.

(キーワード): 多発性脳梗塞 / 脳血管障害 / 抗リン脂質抗体 / 抗カルジオリピン抗体 / ループスアンチコアグラント

川井尚臣, 峯秀樹, 横井健治, 三ツ井貴夫, 土橋孝之, 柏木節子, 斎藤史郎, 赤池雅史 :
HTLV-1 感染に関連した自己免疫性甲状腺疾患の存在,
日本医事新報, Vol.3716, 1995年. Hisaomi Kawai, Masashi Akaike, Kenji Yokoi, Yoshihiko Nishida, Makoto Kunishige, Hideki Mine and Shiro Saito :
Mitochondrial encephalomyopathy with autosomal dominant inheritance, --- a clinical and genetic entity of mitochondrial diseases ---,
Muscle & nerve, Vol.18, No.7, 753-760, 1995.

(キーワード): Mitochondrial encephalomyopathy / autosomal dominant inheritance / mitochondrial DNA / Multiple Deletion / Non-D-Loop Region

Kenji Yokoi, Hisaomi Kawai, Masashi Akaike, Hideki Mine and Shiro Saito :
Presence of human T-lymphotropic virus type II-related genes in DNA of peripheral leukocytes from patients with autoimmune thyroid diseases,
Journal of Medical Virology, Vol.45, No.4, 392-398, 1995.

(キーワード): Graves' Diseases / Hashimoto's Thyroiditis / Human T-lymphotropic virus type 1 / Retrovirus

赤池雅史, 川井尚臣, 国重誠, 斎藤史郎 :
無症状の母親に筋ミトコンドリア異常が認められたKearns-Sayre症候群の1例,
臨床神経学, Vol.35, No.2, 190-194, 1995年.

(キーワード): ミトコンドリア脳筋症 / Kearns-Sayre症候群 / 慢性進行性外眼筋麻痺 / 遺伝性 / ミトコンドリアDNA

Hisaomi Kawai, Kenji Yokoi, Masashi Akaike, Makoto Kunishige, Masahiro Abe, Y Tanouchi, Hideki Mine, Y Mimura and Shiro Saito :
Graves' disease in HTLV-I carriers,
Journal of molecular medicine, Vol.73, No.2, 85-88, 1995.

(キーワード): human T-lymphotropic virus type I / ATL adult T-cell leukemia / HAM HTLV-I associated myelopathy / TSP tropical spastic paraparesis

安藤公, 赤池雅史, 加藤道久, 荒瀬友子, 田村雅人 :
低分子ヘパリンによる抗凝固治療法を併用し救命し得た急性抗汎型肺血栓塞栓症の1例,
ICUとCCU, Vol.19, No.7, 641-646, 1995年. 川井恵子, 赤池雅史, 井出眞, 新谷保実, 板東浩, 斎藤史郎 :
慢性甲状腺炎の経過中にインスリン依存性糖尿病を発生した多腺性自己免疫症候群3型の1例,
ホルモンと臨床, Vol.43, 217-221, 1995年. 赤池雅史, 瀬戸山操, 田村隆一, 中尾克之, 西内健, 林郁郎, 松本直也, 横井健治, 斎藤史郎 :
冠動脈疾患を合併した高脂血症に対するSimvastatinの有用性,
基礎と臨床, Vol.28, No.13, 4289-4295, 1994年. 日野明子, 中平晴仁, 小原卓爾, 久保克之, 原田武彦, 赤池雅史, 中村宗夫 :
心房浸潤による心房細動を初発症状とした悪性リンパ腫の1剖検例,
呼吸と循環, Vol.42, No.11, 1119-1123, 1994年.

(キーワード): 悪性リンパ腫 / 心房細動 / 心浸潤

斎藤美穂, 川井尚臣, 足立克仁, 赤池雅史 :
Becker型筋ジストロフィーにおける心不全の病態とその発生機序,
臨床神経学, Vol.34, No.2, 134-140, 1994年.

(キーワード): Becker型筋ジストロフィー / 心不全 (cardiac failure) / 僧帽弁輪径拡大 / 僧帽弁閉鎖不全症

Masashi Akaike, Takeshi Nishiuchi, Naoya Mtsumoto, Hisaomi Kawai and Shiro Saito :
Enhanced Secretion and Impaired Natriuretic Natriuretic Action of Atrial Natriuretic Peptide in Response to Hypertonic saline Infusion in Patients with Essential Hypertension,
Journal of Human Hypertension, Vol.8, No.1, 15-18, 1994.

(キーワード): Atrial Natriuretic Peptide / Saline Infusion / Essential Hypertension

横井健治, 赤池雅史, 重清俊雄, 斎藤史郎 :
抗リン脂質抗体陽性の高齢者大動脈炎症候群の1例,
日本老年医学会雑誌, Vol.31, No.9, 716-719, 1994年.

(キーワード): 大動脈炎症候群 / ループスアンチコアグラント / 抗カルジオリピン抗体 / MRアンギオグラフィー / 閉塞性血管病変

横井健治, 川井尚臣, 峯秀樹, 赤池雅史, 安倍正博, 国重誠, 三ツ井貴夫, 斎藤史郎 :
バセドウ病を発症したHTLV-Iキャリアの2家系3症例,
ホルモンと臨床, Vol.42, 94-97, 1994年. 日野明子, 赤池雅史, 横越浩, 西田善彦, 斎藤史郎, 上田博巳, 曽我哲朗, 関貫聖二, 松本圭蔵, 佐野壽昭 :
中枢性尿崩症を合併したリンパ球性下垂体炎の1例,
ホルモンと臨床, Vol.42, No.10, 71(971)-75(975), 1994年. 赤池雅史, 西内健, 小原聡彦, 岡内泰弘, 川井尚臣, 斎藤史郎 :
術前診断しえたUnroofed Coronary Sinusの1例,
呼吸と循環, Vol.41, No.9, 905-909, 1993年.

(キーワード): 冠静脈洞左房交通症 / 心超音波断層法 / 経食道心エコー法

赤池雅史, 横井健治, 和田美智子, 瀬部俊彦, 重清俊雄, 川井尚臣, 斎藤史郎 :
腹部真性大動脈瘤に汎播種性血管内凝固を合併した2症例と凝固線溶系の活性化,
呼吸と循環, Vol.41, No.3, 267-270, 1993年.

(キーワード): 腹部大動脈瘤 / 汎播種性血管内凝固 / 消費性凝固障害

川井尚臣, 赤池雅史, 横井健治, 玉木康民, 斎藤史郎 :
常染色体優性の遺伝型を示すミトコンドリアミオパチー, --- 自験例と貢献例における臨床的特徴とミトコンドリアDNA異常 ---,
臨床神経学, Vol.33, No.2, 162, 1993年.

(キーワード): ミトコンドリアミオパチー / 常染色体優性遺伝 / ミトコンドリア DNA / 欠失 / Non-D-Loop領域

川井尚臣, 横井健治, 赤池雅史, 土橋孝之, 近藤彰, 仁木伸二, 有井敬治, 玉木康民, 斎藤美穂, 斎藤史郎 :
橋本病患者の白血球DNAに見出されたHTLV-2プロウイルスDNA,
医学のあゆみ, Vol.164, No.2, 151-152, 1993年. 日野明子, 赤池雅史, 岡川和人, 小阪昌明, 斎藤史郎 :
rhG-CSFが著効を示した塩酸チクロピジンによる再生不良貧血の1例,
Biotherapy, Vol.6, No.11, 1713-1717, 1992年.

(キーワード): 塩酸チクロピジン / 無顆粒球症 / 遺伝子組み換え型ヒト顆粒球コロニー形成刺激因子 / リンパ球幼若化試験

三木理, 北川哲也, 吉栖正, 増田裕, 加藤逸夫, 江川善康, 瀬部俊彦, 赤池雅史 :
播種性血管内凝固症候群(DIC)と腎不全を合併した高齢者腹部大動脈瘤の1手術治験例,
四国医学雑誌, Vol.48, No.1-3, 45-50, 1992年. Masashi Akaike, Fuminobu Ishikura, Seiki Nagata, Kohji Kimura and Kunio Miyatake :
Direct secretion from left atrium and pulmonary extraction of human atrial natriuretic peptide,
American Heart Journal, Vol.123, No.4 Pt1, 984-989, 1992.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/0002-8703(92)90707-3
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/0002-8703(92)90707-3

(DOI: 10.1016/0002-8703(92)90707-3) Kenji Yokoi, Masashi Akaike, Takeshi Nishiuchi, Hisaomi Kawai and Shiro Saito :
Scar Formation in the Cardiac Conduction System of a Patient,
Cardiology, Vol.81, 378-383, 1992.

(キーワード): Complete Atrioventricular Block / Takaysu's Arteritis / Autoimmune Disease

Jun Tamai, Seiki Nagata, Fuminobu Ishikura, Masashi Akaike and Kunio Miyatake :
Alterations in Atrial Filling Fraction in Patients with Mitral Stenosis After Percutaneous Transvenous Mitral Commissurotomv,
The American Journal of Cardiology, Vol.6, 247-251, 1992.

(キーワード): Atrial Transport / Sinus Rhythm / Continuous-Wave Doppler

Takayuki Tsuchihashi, Hisaomi Kawai, Masashi Akaike, Hideo Takahashi and Shiro Saito :
Determination of Calcitonin Gene-Related Peptid(CGRP) in Plasma and Cerebrospinal spinal Fluid in patients with Various Diseases,
Biomedical Research (India), Vol.13, No.Supplement 2, 305-307, 1992. Seiki Nagata, Fuminobu Ishikura, Takashi Yamabe, Masashi Akaike, Kohji Kimura and Kunio Miyatake :
Balloon diameter of the Inoue balloon catheter during percutaneous transvenous mitral commissurotomy: clinical and experimental study,
Catheterization and cardiovascular diagnosis, Vol.23, No.1, 14-19, 1991. Fuminobu Ishikura, Seiki Nagata, Masashi Akaike, Jun Tamai and Kunio Miyatake :
Effects of percutaneous transvenous mitral commissurotomy on levels of plasma atrial natriuretic peptide during exercise,
The American Journal of Cardiology, Vol.67, No.1, 74-78, 1991. Jun Tamai, Seiki Nagata, Masashi Akaike, Fuminobu Ishikura, Koji Kimura, Makoto Takamiya, Kunio Miyatake and Yasuharu Nimura :
Improvement in mitral flow dynamics during exercise after percutaneous transvenous mitral commissurotomy. Noninvasive evaluation using continuous wave Doppler technique,
Circulation, Vol.81, No.1, 46-51, 1990. 赤池雅史, 星島康男, 秋山靖人, 吉田恭典, 松本勲 :
月経時喀血を呈した肺子宮内膜症の1例,
臨床雑誌内科, Vol.61, No.5, 945-947, 1988年. 赤池雅史, 竹田勝則, 宮崎修一, 井石安比古, 小阪昌明, 斎藤史郎 :
胃病変を主とした成人T細胞性リンパ腫の1症例,
日本内科学会雑誌, Vol.76, No.1, 144-145, 1987年.

MISC

赤池雅史, 川野卓二, 宮田政徳, 吉田博, 川瀬和也, 久保田祐歌, 上岡麻衣子 :
2015年度徳島大学FD推進プログラムの実施報告,
大学教育研究ジャーナル, No.13, 94-118, 2016年.

(徳島大学機関リポジトリ): ● Metadata: 110937
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762396366208

(徳島大学機関リポジトリ: 110937, CiNii: 1050845762396366208) 赤池雅史, 川野卓二, 宮田政徳, 吉田博, 川瀬和也, 上岡麻衣子 :
2014年度徳島大学FD推進プログラムの実施報告,
大学教育研究ジャーナル, No.12, 90-111, 2015年.

(キーワード): 新任教員研修 / カリキュラムマップ / 授業コンサルテーション / 大学教育カンファレンス
(徳島大学機関リポジトリ): ● Metadata: 110965

(徳島大学機関リポジトリ: 110965) Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
Circulation, Vol.118, S_749, 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
Circulation, Vol.118, S_651, 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
Eur Heart J, Vol.29, 505-732, 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
Journal of the American Society of Echocardiography, Vol.21, 552, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 550, 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
Journal of the American Society of Echocardiography, Vol.21, 545, 2008. S Nishio, Hirotsugu Yamada, H Motonari, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
Journal of the American Society of Echocardiography, Vol.21, 543, 2008. Kenya Kusunose, K Takechi, Hirotsugu Yamada, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku and Y Maeda :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study).,
Journal of the American Society of Echocardiography, Vol.21, 538, 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
Journal of the American Society of Echocardiography, Vol.21, 524, 2008. 岩瀬俊, 黒部裕嗣, 八木秀介, 原朋子, 長楽雅仁, 藤村光則, 尾崎修治, 赤池雅史, 安部正博, 増田裕, 東博之, 松本俊夫, 北川哲也 :
末梢単核球細胞を用いた抹消動脈閉塞症に対する新たな血管新生治療の試み,
四国医学雑誌, Vol.62, No.3,4, 137-141, 2006年.

(徳島大学機関リポジトリ): ● Metadata: 49311

(徳島大学機関リポジトリ: 49311) Kenya Kusunose, Hirotsugu Yamada, Rino Suzukawa, Yukina Hirata, Masami Yamao, Takayuki Ise, Shusuke Yagi, Masashi Akaike and Masataka Sata :
Effects of Transthoracic Echocardiographic Simulator Training on Performance and Satisfaction in Medical Students.,
Journal of the American Society of Echocardiography, Vol.29, No.4, 375-377, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.echo.2015.12.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26743736; ● Summary page in Scopus @ Elsevier: 2-s2.0-84960912424

(DOI: 10.1016/j.echo.2015.12.002, PubMed: 26743736, Elsevier: Scopus)

総説・解説

赤池雅史 :
多職種連携教育で推進する医療教育学,
日本栄養学教育学会雑誌, Vol.3, No.1, 10-14, 2018年.

(徳島大学機関リポジトリ): ● Metadata: 119104

(徳島大学機関リポジトリ: 119104) 赤池雅史 :
医学部における教育評価の特殊性 ―臨床医学の面から―,
医学教育, Vol.47, No.2, 63-68, 2016年4月.

(徳島大学機関リポジトリ): ● Metadata: 119084

(徳島大学機関リポジトリ: 119084) 石井亜由美, 西川幸治, 伊勢孝之, 門田宗之, 八木秀介, 岩瀬俊, 木下肇, 阪田美穂, 早渕康信, 北川哲也, 赤池雅史, 加藤真介, 佐田政隆 :
単心室症患児の開心術後にフェイススケールを用いて心臓リハビリテーションを試みた1症例,
心臓, Vol.48, No.2, 181-186, 2016年2月.

(キーワード): 心臓リハビリテーション / 小児 (infant) / フェイススケール

赤池雅史 :
これからの医学教育∼総合診療への期待∼,
日本プライマリ・ケア連合学会四国支部論文集, Vol.8, 2-5, 2015年6月. 赤池雅史 :
クリニカル・クラークシップの現状と展望∼求められる指導医像とは∼,
徳島市民病院医学雑誌, Vol.29, 1-4, 2015年. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性(第11回若手奨励賞受賞論文),
四国医学雑誌, Vol.70, No.3, 4, 87-92, 2014年8月.

(要約): 【Background】 Percutaneous transluminal renal angioplasty (PTRA) is recommended for patients with heart failure due to renovascular hypertension ; however, the clinical characteristics of the patients and the effects of PTRA on heart failure and cardiorenal function have not been elucidated. 【Methods】 We retrospectively analyzed data for 4 PTRA-treated patients (male/female, 1/3 ; mean age, 70.0±10 years ; mean left ventricular ejection fraction, 51.5±15.2%) with heart failure due to renovascular hypertension and evaluated the effects of PTRA on heart failure and cardiorenal function 6 months after treatment. 【Results】 All patients had pro-arteriosclerotic diseases including diabetes mellitus, essential thrombocythemia, heparin cofactor II deficency, metabolic syndrome, and familial hypercholesterolemia, and 3 patients had ischemic heart disease. No abdominal bruit was heard and mean plasma renin activity was 4.5±3.6 ng/ml/hr, which was not elevated, contrary to expectation. All contralateral kidneys of PTRA were nonfunctioning, suggesting bilateral kidneys were disturbed in all patients. In all patients, PTRA was successfully performed and resolved heart failure. PTRA resulted in decreases in systolic blood pressure from 157±18 to 124±8.6 mmHg, mean serum creatinine from 3.2±2.6 to 2.7±2.2 mg/dl, and mean BNP from 919±998 to 243±291 pg/ml at 6 months after treatment. PTRA did not change left ventricular ejection fraction, a parameter of systolic fraction evaluated by an echocardiogram ; however, PTRA improved E/e', a parameter of left ventricular diastolic fraction, from 16.1±5.2 to 9.7±3.7. None of the patients were hospitalized due to heart failure during the 6-month period after PTRA. 【Conclusions】 Patients with heart failure with cardiovascular risk factors should be screened for renovascular hypertension regardless of abdominal bruit or plasma renin activity. PTRA is effective for resolving heart failure and for improving renal and cardiac diastolic functions in patients with renovascular hypertension complicated with heart failure.
(キーワード): heart failure / cardiac disturbance syndrome / percutaneous transluminal renal angioplasty
(徳島大学機関リポジトリ): ● Metadata: 109759
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050001337734629888

(徳島大学機関リポジトリ: 109759, CiNii: 1050001337734629888) Masashi Akaike :
Pentraxin-3, --- A potential novel biomarker detecting vulnerable plaque and predicting prognosis in acute myocardial infarction ---,
Circulation Journal, Vol.78, No.1, 65-66, 2014.

(キーワード): C-Reactive Protein / Coronary Artery Disease / Female / Humans / Male / Myocardial Infarction / Percutaneous Coronary Intervention / Plaque, Atherosclerotic / Serum Amyloid P-Component
(出版サイトへのリンク): ● Publication site (DOI): 10.1253/circj.CJ-13-1424
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24284958; ● Search Scopus @ Elsevier (PMID): 24284958; ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-13-1424

(DOI: 10.1253/circj.CJ-13-1424, PubMed: 24284958) 足立克仁, 岩瀬俊, 赤池雅史, 斎藤美穂, 柏木節子, 橋口修二, 佐田政隆, 髙尾正一郎, 原田雅史, 川井尚臣 :
Duchenne型筋ジストロフィー女性保因者における心臓MRIガドリニウム遅延造影と下腿筋CT,
医療, Vol.67, No.2, 63-69, 2013年2月.

(キーワード): Duchenne型筋ジストロフィー / 保因者 / 心臓MRI / ガドリニウム遅延造影 / 心機能障害 / CT
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522262181098698368; ● Summary page in Scopus @ Elsevier: 2-s2.0-84876390340

(CiNii: 1522262181098698368, Elsevier: Scopus) Shusuke Yagi, Ken-ichi Aihara, Yasumasa Ikeda, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Effects of Statins on Cardiorenal Syndrome.,
International Journal of Vascular Medicine, Vol.2012, 162545, Jun. 2012.

(要約): Cardiovascular disease and renal disease have a close relationship that forms a vicious cycle as a cardiorenal syndrome (CRS). Oxidative stress, endothelial dysfunction, and vascular inflammation could be therapeutic targets when the renin-angiotensin-aldosterone system is activated by accumulation of conventional cardiovascular risk factors; however, a strategy for management of CRS has not been established yet. Statins, HMG-CoA reductase inhibitors, have not only cholesterol-lowering effects but also pleiotropic effects on cardiovascular systems, including anti-inflammatory and antioxidant effects and improvement of nitric oxide bioavailability. Since recent studies have indicated that statins have beneficial effects on chronic kidney disease and heart failure as well as coronary artery disease in cholesterol-lowering-dependent/independent manners, treatment with statins might be a successful strategy for preventing deterioration of CRS.
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2012/162545
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22792467; ● Search Scopus @ Elsevier (PMID): 22792467; ● Search Scopus @ Elsevier (DOI): 10.1155/2012/162545

(DOI: 10.1155/2012/162545, PubMed: 22792467) Yasumasa Ikeda, Ken-ichi Aihara, Sumiko Yoshida, Masashi Akaike and Toshio Matsumoto :
Effects of androgens on cardiovascular remodeling.,
The Journal of Endocrinology, Apr. 2012.

(要約): Androgens, the male sex hormones, exert various biological effects on many target organs through the transcriptional effects of the nuclear androgen receptor (AR). ARs are expressed not only in classical target organs, such as the brain, genital organs, bone, and skeletal muscles, but also in the cardiovascular system. Because the female sex hormones estrogens are well known to protect against cardiovascular disease, sex has been considered to have a significant clinical impact on cardiovascular mortality. However, the influence of androgens on the cardiovascular system has not been fully elucidated. To clarify this issue, we analyzed the effects of administration of angiotensin II and doxorubicin, an anticancer agent, in a loading model in male wild-type and AR-deficient mice. In this review, we focus on the actions of androgens as potential targets for the prevention of cardiovascular diseases in males.
(出版サイトへのリンク): ● Publication site (DOI): 10.1530/JOE-12-0126
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22493003; ● Search Scopus @ Elsevier (PMID): 22493003; ● Search Scopus @ Elsevier (DOI): 10.1530/JOE-12-0126

(DOI: 10.1530/JOE-12-0126, PubMed: 22493003) 赤池雅史 :
後期専門研修医の教育のあり方,
日本臨床麻酔学会誌, Vol.31, No.7, 916, 2011年11月.

(キーワード): 臨床研修 / 専門研修プログラム / 専門医 / キャリア形成 / 医学教育
(出版サイトへのリンク): ● Publication site (DOI): 10.2199/jjsca.31.916
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571417125709135232; ● Search Scopus @ Elsevier (DOI): 10.2199/jjsca.31.916

(DOI: 10.2199/jjsca.31.916, CiNii: 1571417125709135232) Ken-ichi Aihara, Yasumasa Ikeda, Shusuke Yagi, Masashi Akaike and Toshio Matsumoto :
Transforming Growth Factor-1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome.,
Cardiology Research and Practice, Vol.2011, 175381, Dec. 2010.

(要約): Transforming growth factor-1 (TGF-1) is a polypeptide member of the transforming growth factor superfamily of cytokines. It is a secreted protein that performs many cellular functions including control of cell growth, cell proliferation, cell differentiation and apoptosis. In the cardiovascular system, TGF-1 plays pivotal roles in the pathogenesis of hypertension, restenosis after percutaneous coronary intervention, atherosclerosis, cardiac hypertrophy and heart failure. In addition, TGF-1 has been shown to be increased in adipose tissue of obese subjects with insulin resistance. Furthermore, TGF-1 is a potent initiator of proliferation of renal mesangial cells leading to chronic kidney disease. Some currently available agents can manipulate TGF-1 expression leading to amelioration of cardiovascular diseases. Thus, an understanding of interactions between chronic kidney disease and metabolic syndrome and the development of cardiovascular diseases is an important issue, and attention should be given to TGF-1 as a crucial factor for regulation and modulation of those pathological conditions.
(出版サイトへのリンク): ● Publication site (DOI): 10.4061/2011/175381
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21234356; ● Search Scopus @ Elsevier (PMID): 21234356; ● Search Scopus @ Elsevier (DOI): 10.4061/2011/175381

(DOI: 10.4061/2011/175381, PubMed: 21234356) Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Heparin Cofactor II as a Novel Vascular Protective Factor Against Atherosclerosis.,
Journal of Atherosclerosis and Thrombosis, Vol.16, No.5, 523-531, Sep. 2009.

(要約): Heparin cofactor II (HCII) specifically inhibits thrombin action at the site of vascular wall injury. We encountered a congenital HCII deficiency patient with advanced multiple atherosclerotic lesions. This patient led us to conduct clinical studies to examine the role of HCII against atherosclerosis. We found that the incidence of in-stent restenosis after percutaneous coronary intervention, severity of carotid atherosclerosis and prevalence of peripheral arterial disease are inversely associated with plasma HCII activity. In order to clarify the vascular protective action of HCII, we generated HCII- deficient mice by gene targeting. In contrast to a previous study, HCII(-/-) mice were embryonically lethal. In HCII(+/-) mice, accelerated intimal hyperplasia and frequent thrombosis were observed after cuff or wire injury of femoral arteries. The number of protease-activated receptor-1 (PAR-1) -positive cells and the gene expression levels of inflammatory cytokines and chemokines were increased in the thickened vascular walls of HCII(+/-) mice. The accelerated intimal hyperplasia in HCII+/- mice with vascular injury was attenuated by human HCII administration. Furthermore, HCII deficiency exaggerated aortic plaque formation with increased oxidative stress in apolipoprotein E(-/-) mice. These results demonstrate that HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis.
(キーワード): Animals / 動脈硬化 (atherosclerosis) / Female / Heparin Cofactor II / Humans / ノックアウトマウス (knockout mice) / ノックアウトマウス (knockout mice) / Recombinant Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.5551/jat.1552
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19729870; ● Search Scopus @ Elsevier (PMID): 19729870; ● Search Scopus @ Elsevier (DOI): 10.5551/jat.1552

(DOI: 10.5551/jat.1552, PubMed: 19729870) 赤池雅史 :
徳島大学の医学教育を考えるー臨床医学教育―,
四国医学雑誌, Vol.63, No.1,2, 5-10, 2007年4月.

(徳島大学機関リポジトリ): ● Metadata: 84163

(徳島大学機関リポジトリ: 84163) 赤池雅史, 松本俊夫 :
NO bioavailability,
CLINICAL CALCIUM, Vol.17, No.6, 864-870, 2007年. 赤池雅史, 松本俊夫 :
血管内皮細胞に対するステロイドの影響と大腿骨頭壊死,
整形外科, Vol.48, 25-29, 2005年. 粟飯原賢一, 赤池雅史, 井上大輔, 東博之, 松本俊夫 :
副甲状腺機能亢進症,
ホルモンと臨床, Vol.52, No.5, 93(483)-96(486), 2004年5月. 松本俊夫, 赤池雅史, 井上大輔 :
内分泌疾患,
臨床雑誌内科, Vol.86, No.6, 1119-1127, 2000年12月. 松本俊夫, 赤池雅史 :
骨と脈管系との関わり,
骨と骨代謝, Vol.12, No.4, 319-323, 1999年. 赤池雅史, 川井尚臣 :
筋ジストロフィーの遺伝子診断, --- とくに悪性肢帯型筋ジストロフィーにおけるα-sarcoglycan(adhalin)の遺伝子異常について ---,
臨床病理, Vol.45, No.2, 136-140, 1997年2月.

(キーワード): 悪性肢帯型筋ジストロフィー / 重症小児常染色体劣性筋ジストロフィー / αーサルコグリカン / アダリン / 遺伝子解析

川井尚臣, 赤池雅史 :
Adhalin欠損悪性肢帯型筋ジストロフィーにおけるadhalin遺伝子の異常,
Annual Review 神経 1996, 261-266, 1996年2月. 川井尚臣, 赤池雅史 :
悪性肢帯型筋ジストロフィーにおけるadhalin遺伝子の異常,
神経内科, Vol.44, No.1, 24-30, 1996年.

(キーワード): Malignant Limb-Girdle Muscular Dystrophy / Adhalin Deficiency / adhalin Gene Mutation

川井尚臣, 赤池雅史 :
筋疾患,
オルソペディクス, Vol.9, No.3, 53-62, 1996年.

(キーワード): 筋疾患の分類 / 多発性筋炎 / 代謝異常ミオパチー / 遺伝性ミオパチー / 遺伝子異常

川井尚臣, 赤池雅史 :
症例研究ミトコンドリア脳筋症,
Medical Student, Vol.6, No.7, 47-51, 1993年. H Yokoi, Hisaomi Kawai, Masashi Akaike, Takao Mitsui, Y Tamaki, Setsuko Kashiwagi and Shiro Saito :
Involvements of HTLV-1 and HTLV-2 in the Pathogenesis Hashimoto Thyroiditis,
80 years of Hashimoto Disease, 115-120, Dec. 1992. 永田正毅, 赤池雅史 :
ドプラーエコー X,心筋症,
臨床雑誌内科, Vol.64, No.5, 911-916, 1989年11月.

講演・発表

Takashi Iwata, Masashi Akaike, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada :
Usefulness of the rubric evaluation as the qualitative evaluation of the laparoscopic training.,
SAGES, Seattle, Apr. 2018. Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada :
Development of the simulator for laparoscopic eye hand coordination training for teaching oneself training,
American Gastrointestinal Endoscopic Surgeons, Apr. 2017. Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Daichi Ishikawa and Mitsuo Shimada :
Development of the simulator for laparoscopic eye hand coordination training for teaching oneself training.,
SAGES, Houston, Mar. 2017. Shusuke Yagi, Takayuki Ise, Masashi Akaike and Masataka Sata :
Adaptive Servo-ventilation Supported Exercise Increases Exercise Capacity in Patients With Severe Heart Failure,
AHA Scientific Sessions 2016, New Orleans, Nov. 2016. Ken-ichi Aihara, Masashi Akaike, Sumiko Yoshida, Yasumasa Ikeda, Shusuke Yagi and Masahiro Abe :
Pleiotropic Effects of Pitavastatin against Vascular Stress in eNOS-deficient Mice,
The 10th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Diseases, Tokyo, Jul. 2016. Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu and Mitsuo Shimada :
Trial of the filipped classroom for open suturing and simulated laparoscopic cholecystectomy for medical.,
Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016. Takashi Iwata, Masashi Akaike, Kouzou Yoshikawa, Jun Higashijima, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, 江藤祥平 and Mitsuo Shimada :
Investigation of training for students who is weak in maneuver of laparoscopic surgery Laborer of the off-the-job training,
Surgical Education Week, Seattle, Apr. 2015. Nhat-Tu Le, Yuichiro Takei, Yuki Izawa-Ishizawa, Kyung-Sun Heo, Hakjoo Lee, Alan V. Smrcka, Benjamin Miller, Kyung Ae Ko, Craig Morrell, Keigi Fujiwara, Masashi Akaike and Jun-ichi Abe :
A HMG-CoA Reductase Inhibitor (statin) Directly Activates Endothelial Erk5 And Prevents Endothelial Dysfunction And Acute Cardiac Allograft Rejection,
AHA scientific sessions 2013, Nov. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Shusuke Yagi, Koji Yamaguchi, Hirotsugu Yamada, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance.,
ESC Congress 2013, Amsterdam, Aug. 2013. K Nishikawa, Shusuke Yagi, Takayuki Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Michio Shimabukuro, Shinsuke Katoh and Masataka Sata :
Visceral fat mass is associated with daily physical activity, leg skeletal muscle mass and fiber intake in healthy men.,
ESC Congress 2013, Amsterdam, Aug. 2013. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Androgen Receptor is Required for Cellular Survival and Angiogenesis in Response to Ischemia via Activation of VEGF Receptor Signaling Pathway Regardless of Sex,
American Heart Association Scientific Session 2012, Nov. 2012. Yasumasa Ikeda, Ken-ichi Aihara, Sumiko Yoshida, Masataka Sata, Masashi Akaike, Toshio Matsumoto and Toshiaki Tamaki :
Heparin Cofactor II Promotes Angiogenesis in Response to Ischemic Hindlimb via an AMPK-eNOS-dependent Manner,
American Heart Association Scientific Sessions 2012, Nov. 2012. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Eicosapentaenoic acid administration ameliorates cardiac remodeling in humans and protects against Ang II-induced cardiovascular remodeling via attenuation of oxidative stress in mice.,
American Heart Association Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, M Kadota, T Hara, S Bando, Toshiyuki Niki, J Hotchi, N Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. A. Takashima, Takayuki Ise, Masashi Akaike, Yuka Ueda, Takashi Iwase, T. Hara, M. Kadota, R. Ohta, K. Ogasawara, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Cardiac Rehabilitation Reduces Levels of Oxidized LDL.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. S. Kimura, Yuka Ueda, Takayuki Ise, Takashi Iwase, K. Maeda, K. Nishikawa, K. Ogasawara, Mika Bando, S. Bando, Toshiyuki Niki, J. Hotchi, Koji Yamaguchi, N. Tomita, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
AHA Scientific Sessions 2012, ロサンゼルス, Nov. 2012. Masashi Akaike :
Current Advances of Medical Education in University of Tokushima,
Current advances in medical education, International conference dedicated to the 70th anniversry of Health Sciences University of Mongolia, ウランバートル, Oct. 2012. Ken-ichi Aihara, Sumiko Yoshida, Yasumasa Ikeda, Masashi Akaike and Toshio Matsumoto :
Heparin cofactor II, a serine protease inhibitor, is a novel regulating factor for glucose metabolism and albuminuria,
Keystone Symposia: Complications of Diabetes: Mechanisms of Injury and Failure of Repair, Mar. 2012. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Kenya Kusunose, Yuka Ueda, N. Tomita, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Masafumi Harada and Masataka Sata :
Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance.,
AHA Scientific Sessions 2011, Orlando, Nov. 2011. Yasumasa Ikeda, Ken-ichi Aihara, Sumiko Yoshida, Yoshitaka Kihira, Keisuke Ishizawa, Yuki Izawa-Ishizawa, Shuhei Tomita, Masataka Sata, Masashi Akaike, Shigeki Kato, Toshio Matsumoto and Toshiaki Tamaki :
Heparin Cofactor Promotes Angiogenesis via an AMPK-eNOS Signaling Pathway,
High Blood Pressure Research Scientific Sessions 2011 Scientific Sessions, Orlando, Sep. 2011. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ストレインイメージング法を用いた心房細動例の左室心筋機能評価―左室圧曲線との同時記録による検討―,
第98回日本循環器学会中国・四国合同地方会, 徳島, 2011年5月. S Nishio, Hirotsugu Yamada, R Tamai, K Endo, S Hayashi, Kenya Kusunose, N Tomita, J Miki, S Bando, S Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Relationship Between Carotid Artery Stiffness Parameter β and Brachial Artery Flow-mediated Dilation in coronary Artery Disease.,
American College of Cardiology 2011, New Orleans, Apr. 2011. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Androgen receptor is essential for cell survival and neovascularization after ischemia.,
American Heart Association Scientific Sessions 2010, Chicago, Nov. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, S. Bando, S. Hisaoka, Kenya Kusunose, Yuka Ueda, H. Takeuchi, Takashi Iwase, N. Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-dependent Changes Of Local Coagulative Response Up To Five Years After Sirolimus-eluting Stent Implantation.,
American Heart Association 2010, Chicago, Nov. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, Toshiyuki Niki, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
American Heart Association 2010, Chicago, Nov. 2010. Y. Hirata, T. Motoki, Hirotsugu Kurobe, Masashi Akaike, M. Tabata, S. Takanashi, T. Igarashi, Tetsuya Kitagawa and Masataka Sata :
Macrophage Polarization in Epicardial Adipose Tissue is Correlated with Severity of Human Coronary Artery Disease.,
American Heart Association 2010, Chicago, Nov. 2010. S. Yoshida, Ken-ichi Aihara, Yasumasa Ikeda, T. Ise, Yuka Ueda, Takashi Iwase, Masashi Akaike, Masataka Sata and T. Matsumoto :
Androgen Receptor is Essential for Cell Survival and Neovascularization after Ischemia.,
American Heart Association 2010, Chicago, Nov. 2010. Kenya Kusunose, Hirotsugu Yamada, S. Nishio, N. Tomita, S. Hayashi, S. Bando, S. Hisaoka, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity Predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography.,
American Heart Association 2010, Chicago, Nov. 2010. Takeshi Soeki, Toshiyuki Niki, S. Bando, S. Hisaoka, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Y. Hirata, N. Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, K. Kangawa and Masataka Sata :
Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway.,
American Heart Association 2010, Chicago, Nov. 2010. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Androgen receptor participants in ischemia-induced tissue damage and angiogenesis in male mice,
23rd Scientific Meeting of the International Society of Hypertension Vancouver, Vancouver, Sep. 2010. Takashi Iwase, S. Takao, Masashi Akaike, K. Adachi, Yuka Ueda, M. Harada, H. Nishitani and Masataka Sata :
Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy Using Cardiac Magnetic Resonance.,
ESC CONGRESS 2010, Stockholm, Aug. 2010. Toshiyuki Niki, Tetsuzo Wakatsuki, Koji Yamaguchi, Kenya Kusunose, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Impact of Statin Theraphy on Local Coagulative Response after sirolimus-eluting Stent Implantation in late chronic Phase.,
ESC CONGRESS 2010, Stockholm, Aug. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Preload on Left Ventricular Dyssynchrony in Patients with Dilated Cardiomyopathy: Assessment with Real-Time Three-Dimensional Echocardiography.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. H Takashima, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, C Mimura, K Endo, M Yamanaka, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Association of Carotid Artery Atherosclerosis with Aortic Valve Sclerosis.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, J Miki, N Tomita, H Takashima, C Mimura, M Yamanaka, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal / Restrictive Transmitral Flow Velocity Pattern Using its Response to Nitroglycerin Spray Oral Administration.,
American Society of Echocardiography 2010 21st Annual Scientific Sessions, San Diego, Jun. 2010. Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Sumiko Yoshida, Yasumasa Ikeda, Uemoto Ryoko, Shusuke Yagi, Takashi Iwase, Hirata Yoichiro, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Plasma heparin cofactor II activity is an independent determinant for cardiac remodeling in subjects with cardiovascular risk factors,
20th International Society for Heart Research(ISHR), Kyoto, May 2010. Ken-ichi Aihara, Yuka Ueda, Takayuki Ise, Sumiko Yoshida, Yasumasa Ikeda, Uemoto Ryoko, Shusuke Yagi, Takashi Iwase, Hirata Yoichiro, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Heparin cofactor II is a novel anticardiac remodeling factor against angiotensin II excess,
20th International Society for Heart Research(ISHR), Kyoto, May 2010. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Exacerbation of cell survival and impaired neovascularization after hindlimb ischemia in male androgen receptor null mice,
20th International Society for Heart Research(ISHR), Kyoto, May 2010. S. Yoshida, K. Aihara, Yuka Ueda, Yasumasa Ikeda, T. Iwase, Masashi Akaike, Masataka Sata and T. Matsumoto :
Exacerbation of Cell Survival and Impaired Neovascularization after Hindlimb Ischemia in Male Androgen Receptor Null Mice.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Y. Hirata, Hirotsugu Kurobe, Masashi Akaike, F. Chikugo, Takaki Hori, Tetsuya Kitagawa and Masataka Sata :
CD-8 Positive T-lymphocyte Infiltration in Epicardial Adipose Tissue in Patients with Coronary Artery Disease.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Masashi Akaike, Ken-ichi Aihara, Yasumasa Ikeda, K. Ishikawa, S. Yoshida, Yuka Ueda, Shusuke Yagi, Takashi Iwase, T. Matsumoto and Masataka Sata :
Glucocorticoid causes vascular endothelial dysfunction through activation of mineralocorticoid receptor.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Ken-ichi Aihara, T. Ise, Yuka Ueda, S. Yoshida, Yasumasa Ikeda, R. Uemoto, Shusuke Yagi, Takashi Iwase, Y. Hirata, Masashi Akaike, Masataka Sata and T. Matsumoto :
Plasma heparin cofactor II activity is an independent determinant for cardiac remodeling in subjects with cardiovascular risk factors.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Y. Hirata, Masashi Akaike, S. Nagahiro and Masataka Sata :
Increased expression of HMGB1 in human and murine atherosclerotic lesions.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Yuka Ueda, Ken-ichi Aihara, T. Ise, S. Yoshida, Yasumasa Ikeda, R. Uemoto, Shusuke Yagi, Takashi Iwase, Y. Hirata, Masashi Akaike, Masataka Sata and T. Matsumoto :
Heparin cofactor II is a novel anticardiac remodeling factoragainst angiotensin II excess.,
XXth World Congress of the International Society for Heart Research 2010, Kyoto, May 2010. Ken-ichi Aihara, Yuichi Fujinaka, Mizuho Kinouchi, Sumiko Yoshida, Yuka Ueda, Kurahashi Kiyoe, Itsuro Endo, Uemoto Ryoko, Shusuke Yagi, Takashi Iwase, Hirata Yoichiro, Suzuki Reiko, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Albuminuria is an independent aggravating factor for visceral fat obesity regardless of diabetes mellitus: a study using abdominal CT scan imaging,
14th International Congress of Endocrinology, Kyoto, Mar. 2010. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Identification of Pseudonormal Transmitral Flow Velocity Pattern using its Change by Nitroglycerin Spray Oral Administration.,
American College of Cardiology 2010, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Doppler Echocardiographic Estimation of Left Ventricular End-diastolic Pressure in Challenging,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Evaluation of Secondary Pulmonary Hypertension by Tricuspid Annular Velocity Profile Using Pulsed Tissue Doppler Imaging.,
第74回日本循環器学会総会・学術集会, Mar. 2010. N Tomita, Hirotsugu Yamada, Kenya Kusunose, S Nishio, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Patent Foramen Ovale by Contrast Realtime 3-dimensional Transesophageal Echocardiography.,
第74回日本循環器学会総会・学術集会, Mar. 2010. K Endo, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata :
N-3 Fatty Acids, IMT and CKD as Risk Factors in Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, J Miki, K Endo, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Evaluation of Stiffness Parameter beta of Common Carotid Artery Obtained by Echo-tracking Method in Coronary Heart Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. T Niki, Takeshi Soeki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Tomita, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Utility of Cardiac Magnetic Resonance for Detection of Cardiac Involvement in Female Carriers of Duchenne Muscular Dystrophy.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Yoshio Taketani, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory and Coagulative Responses after Coronary Artery Stenting with Drug-Eluting Stent.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Takeshi Soeki, Kunihiko Koshiba, T Niki, Kenya Kusunose, Koji Yamaguchi, Y Hirata, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
Ghrelin Protects Heart against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Detection of Myocardial Amyloid Involvement Using 2-Dimentional Speckle Tracking Echocardiography: Utilization of Inner and Outer Myocardial Strain and Strain Rate.,
第74回日本循環器学会総会・学術集会, Mar. 2010. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Time-Dependent Changes of Local Coagulative Response up to Five Years after Sirolimus-Eluting Stent Implantation.,
第74回日本循環器学会総会・学術集会, Mar. 2010. C Mimura, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, H Takashima, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Predictive Value of Subepicardial Fat Thickness in Coronary Artery Sclerosis in Comparison with Intima-media Thickness,
第74回日本循環器学会総会・学術集会, Mar. 2010. Ken-ichi Aihara, Yuichi Fujinaka, Mizuho Kinouchi, Sumiko Yoshida, Takashi Iwase, Masashi Akaike, Yuka Ueda, Kurahashi Kiyoe, Itsuro Endo, Uemoto Ryoko, Shusuke Yagi, Takashi Iwase, Hirata Yoichiro, Suzuki Reiko, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Albuminuria is an independent aggravating factor for visceral fat obesity regardless of diabetes mellitus: a study using abdominal CT scan imaging,
14th International Congress of Endocrinology, Kyoto, Japan, Mar. 2010. Ken-ichi Aihara, Sumiko Yoshida, Yuka Ueda, Uemoto Ryoko, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Rosuvastatin attenuates left ventricular mass even in subjects without cardiac hypertrophy,
14th International Congress of Endocrinology, Kyoto, Japan, Mar. 2010. Yuka Ueda, Ken-ichi Aihara, Takayuki Ise, Sumiko Yoshida, Shusuke Yagi, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Exacerbation of Angiotensin ll-induced Cardiac Remodeling through Enhancement of NADPH oxidase-TGF- 1 Pathway in Heparin Cofactor ll-Deficient Mice,
Scientific Sessions 2009, American Heart Association, Florida, Nov. 2009. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Yuka Ueda, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Kurahashi Kiyoe, Itsuro Endo, Yuichi Fujinaka, Nishio Susumu, Hirotsugu Yamada, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Dehydroepiandrosterone sulfate is an endothelial function-independent protective factor against carotid atherosclerosis.,
Scientific Sessions 2009, American Heart Association, Florida, Nov. 2009. Ken-ichi Aihara, Mizuho Kinouchi, Yuichi Fujinaka, Sumiko Yoshida, Yuka Ueda, Kurahashi Kiyoe, Itsuro Endo, Uemoto Ryoko, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Toshio Matsumoto :
Albuminuria is an independent aggravating factor for visceral fat obesity regardless of diabetes mellitus: a study using abdominal CT scan imaging,
Scientific Sessions 2009, American Heart Association, Florida, Nov. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Yoshio Taketani, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Predictors of Local Persistent Hypercoagulability After Sirolimus-eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.,
American Heart Association 2009, Nov. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, K Endo, H Takashima, C Mimura, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prognostic Value of Changes in Transmitral Flow Velocity Pattern During Leg Positive Pressure in Mild Heart Failure: A Clinical Application of "Preload Stress Echocardiography",
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting. Bare Metal vs Sirolimus-Eluting vs Paclitaxel-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response After Coronary Artery Stenting with Drug-Eluting Stent.,
American Heart Association 2009, Nov. 2009. Kunihiko Koshiba, Takeshi Soeki, T Niki, Kenya Kusunose, Y Hirata, Koji Yamaguchi, Shusuke Yagi, N Tomita, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Kenji Kangawa and Masataka Sata :
C-type Natriuretic Peptide Ameliorates the Progression of Experimental Autoimmune Myocarditis.,
American Heart Association 2009, Nov. 2009. Tatsuya Okada, Tomiaki Morikawa, Yuu Tamaki, Masato Tagi, Hiroki Moriguchi, Yoshiyasu Terashima, Hiroaki Mikasa, Masashi Akaike and Yoneo Yano :
Scenario making support in PBL,
E-Learn 2009, Vancouver, Oct. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting -BMS vs SES vs PES-.,
ESC Congress 2009, Aug. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Kenya Kusunose, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma concentration of pentraxin 3 is a useful marker for monitoring the anti-plaque effect of telmisartan.,
ESC Congress 2009, Aug. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local persistent hypercoagulability after drug-eluting stent implantation: siroliumus-eluting stent vs. paclitaxel-eluting stent.,
ESC Congress 2009, Aug. 2009. Y Fukuda, Takeshi Soeki, N Fukuda, S Morishita, K Sakabe, H Shinohara, Y Tamura, Masashi Akaike, Tetsuzo Wakatsuki, Hirotsugu Yamada, Takashi Iwase, Shusuke Yagi, Kunihiko Koshiba, Koji Yamaguchi, Kenya Kusunose, T Niki and Masataka Sata :
Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, S Yoshida, Y Sumitomo, Ken-ichi Aihara, Toshio Matsumoto and Masataka Sata :
Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Y Hirata, H Iwata, K Nakamura, Y Sakai, N Tomita, T Niki, Kenya Kusunose, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Shinji Nagahiro and Masataka Sata :
Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, T Niki, Kunihiko Koshiba, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, H Satoh and Masataka Sata :
Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, S Yoshida, Y Sumitomo, Kenya Kusunose, T Niki, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Takashi Iwase, N Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto and Masataka Sata :
Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Koji Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, Kunihiko Koshiba, N Tomita, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation: Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takashi Iwase, Shoichiro Takao, Masashi Akaike, K Adachi, Y Sumitomo, Shusuke Yagi, T Niki, Kenya Kusunose, N Sakamoto, Y Hirata, Koji Yamaguchi, Kunihiko Koshiba, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masafumi Harada, Hiromu Nishitani and Masataka Sata :
Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy - the Utility of Cardiac Magnetic Resonance.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, N Tomita, S Nishio, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Takeshi Soeki, Kunihiko Koshiba, T Niki, Y Hirata, N Tomita, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Effect of Ghrelin on Autonomic Activity in Healthy Volunteers.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical utility of B-Flowimaging on ultrasound examination of carotid artery.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. M Yamanaka, Kenya Kusunose, Hirotsugu Yamada, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments.,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Tetsuzo Wakatsuki, Koji Yamaguchi, T Niki, Kenya Kusunose, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-Term Local Inflammatory Response after Coronary Artery Stenting -BMS vs. SES vs. PES-,
73th Annual scientific meeting of the Japanese circulation society, Mar. 2009. Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
The Mitral L-wave Predicts Adverse Response to Volume Overloading in Patients with Atrial Fibrillation.,
58th American College of Cardiology, Mar. 2009. S Nishio, Hirotsugu Yamada, Kenya Kusunose, N Tomita, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Shusuke Yagi, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Velocity Profile by Pulsed Tissue Doppler Imaging for the Assessment of Serial Change of Pulmonary Artery Pressure in Secondary Pulmonary Hypertension.,
58th American College of Cardiology, Mar. 2009. Ken-ichi Aihara, Sumiko Yoshida, Takayuki Ise, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Kurahashi Kiyoe, Itsuro Endo, Yuichi Fujinaka, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Increased serum triglyceride but not LDL cholesterol is associated with left ventricular diastolic dysfunction.,
Scientific Sessions 2008, American Heart Association, New Orleans, Nov. 2008. Takayuki Ise, Ken-ichi Aihara, Sumiko Yoshida, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Ishikawa Kazue, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Plasma Heparin Cofactor II Activity Is Inversely Associated with Left Atrial Volume and Left Ventricular Diastolic Dysfunction.,
Scientific Sessions 2008, American Heart Association, New Orleans, Nov. 2008. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Kurahashi Kiyoe, Itsuro Endo, Yuichi Fujinaka, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
Dehydroepiandrosterone sulfate is an antivascular remodeling factor in elderly individuals.,
Scientific Sessions 2008, American Heart Association, New Orleans, Nov. 2008. Takashi Iwase, Hirotsugu Kurobe, Masashi Akaike, Shunji Nakano, Sumiko Yoshida, Sumitomo Yuka, Shusuke Yagi, Ken-ichi Aihara, Shuji Ozaki, Masahiro Abe, Natsuo Yasui, Toshio Matsumoto, Tetsuya Kitagawa and Masataka Sata :
Erythropoietin administration with autologous blood donation - a novel strategy to enhance mobilization of circulating progenitor cells,
American Heart Association Sessions 2008, New Orleans, Nov. 2008. Masashi Akaike, Ken-ichi Aihara, Yasumasa Ikeda, Shusuke Yagi, Ishikawa Kazue, Sumitomo Yuka, Sumiko Yoshida, Takashi Iwase, Toshio Matsumoto and Masataka Sata :
Pitavastatin, an HMG-CoA Reductase Inhibitor, Prevents Glucocorticoid-induced Hypertension through Ameliorating Imbalance of Oxidative Stress and Nitric Oxide Production,
American Heart Association Sessions 2008, New Orleans, Nov. 2008. Tetsuzo Wakatsuki, K Yamaguchi, T Niki, Kenya Kusunose, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Masataka Sata :
Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.,
American Heart Association 2008, New Orleans, Nov. 2008. K Yamaguchi, Tetsuzo Wakatsuki, T Niki, Kenya Kusunose, K Koshiba, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.,
American Heart Association 2008, New Orleans, Nov. 2008. Tetsuzo Wakatsuki, K Yamaguchi, Kenya Kusunose, T Niki, K Koshiba, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.,
ESC Congress 2008, Munich, Aug. 2008. Masashi Akaike, Ken-ichi Aihara, Shusuke Yagi, Yasumasa Ikeda, Ishikawa Kazue, Takayuki Ise, Sumiko Yoshida, Sumitomo Yuka, Takashi Iwase and Toshio Matsumoto :
Pitavastatin, an HMG-CoA Reductase Inhibitor, Prevents Glucocorticoid-induced Hypertension through Increased Nitric Oxide Production as a Pleiotropic Effect on Vascular Endothelial Cells,
Hypertension 2008 18th Scientific Meeting of the European Society of Hypertension 22nd Scientific Meeting of the International Society of Hypertension, Berlin, Jun. 2008. Takashi Iwase, Masashi Akaike, Shunji Nakano, Takayuki Ise, Sumiko Yoshida, Sumitomo Yuka, Shusuke Yagi, Ken-ichi Aihara, Natsuo Yasui and Toshio Matsumoto :
Single erythropoietin administration with autologous blood donation - a novel strategy to enhance mobilization of endothelial progenitor cells,
22nd Scientific Meeting of the International Society of Hypertension 2008, Berlin, Germany, Berlin, Jun. 2008. Sumitomo Yuka, Ken-ichi Aihara, Takayuki Ise, Sumiko Yoshida, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Toshio Matsumoto :
Acceleration of angiotensin II-induced cardiac remodeling through enhancement of oxidative stress in heparin cofactor II knockout mice,
22nd Scientific Meeting of the International Society of Hypertension 2008, Berlin, Germany, Berlin, Jun. 2008. Sumiko Yoshida, Ken-ichi Aihara, Takayuki Ise, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Toshio Matsumoto :
Dehydroepiandrosterone sulfate regulates carotid blood flow in elderly individuals,
22nd Scientific Meeting of the International Society of Hypertension 2008, Berlin, Germany, Berlin, Jun. 2008. Ken-ichi Aihara, Takayuki Ise, Sumiko Yoshida, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Toshio Matsumoto :
Serum Lipid Disorder is Associated with Left Ventricular Diastolic Dysfunction in Elderly Individuals,
22nd Scientific Meeting of the International Society of Hypertension 2008, Berlin, Germany, Berlin, Jun. 2008. Ken-ichi Aihara, Takayuki Ise, Sumiko Yoshida, Sumitomo Yuka, Shusuke Yagi, Takashi Iwase, Masashi Akaike and Toshio Matsumoto :
The active form of vitamin D, 1,25(OH)2D3, prevents vascular remodeling and glucose intolerance in elderly individuals,
22nd Scientific Meeting of the International Society of Hypertension 2008, Berlin, Germany, Berlin, Jun. 2008. S Nishio, Hirotsugu Yamada, H Motonari, H Okada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, M Sato, H Hiraoka, H Kawano, Y Tadatsu, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. S Nishio, Hirotsugu Yamada, Kenya Kusunose, Y Tadatsu, M Sato, H Hiraoka, H Kawano, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, K Takechi, S Nishio, Y Tadatsu, T Niki, K Yamaguchi, K Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, M Choraku, Y Maeda and Hirotsugu Yamada :
Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study),
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, T Niki, K Yamaguchi, K Koshiba, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.,
18th Annual Scientific Sessions of the American Society of Echocardiography, Toronto, Jun. 2008. Kenya Kusunose, Hirotsugu Yamada, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
Effect of Preload Increment on Early Diastolic Transmitral and Mitral Annular Velocities in Patients with Old Myocardial Infarction.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Hirotsugu Yamada, Kenya Kusunose, S Nishio, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki and Masashi Akaike :
The Mitral L-wave Predicts the Cardiac Response to an Increase of Preload in Atrial Fibrillation.,
The 16th Congress of the international Cardiac Doppler Society, Kobe, Apr. 2008. Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Shusuke Yagi, Takashi Iwase, Sumitomo Yuka, Masataka Sata, Kato Shigeaki and Toshio Matsumoto :
Heparin Cofactor II Deficiency Causes Accelerated Thrombosis and Atherosclerosis in Mice,
American Heart Association Scientific Sessions 2006, Chicago, USA, Nov. 2006. Ken-ichi Aihara, Masashi Akaike, Yasumasa Ikeda, Fujimura Mitsunori, Hashizume Shunji, Takashi Iwase, Shusuke Yagi, Kondo Akira, Hiroyuki Azuma and Toshio Matsumoto :
Valsartan Enhances Nitric Oxide Bioavailability and Reduces Arterial Stiffness in Patients with Essential Hypertension,
The 21st Scientific Meeting of the International Society of Hypertension, 2006, Fukuoka, Japan, Oct. 2006. Hirotsugu Kurobe, Yuki Izawa, Y Fukuhara, Tamotsu Kanbara, A Kurushima, Ken-ichi Aihara, Masashi Akaike, Masashi Kano, Takashi Kitaichi, Yutaka Masuda, Hiroyuki Azuma, Toshiaki Tamaki, Toshio Matsumoto, Tetsuya Kitagawa, Shuhei Tomita and Masanori Yoshizumi :
HIF-ARNT transcriptional system in Tcells has a pivotal role in vascular inflammation and remodeling,
XIL International Symposium on Atherosclerosis, Italy, Jun. 2006. Yutaka Masuda, H Kurobe, Takashi Kitaichi, Masashi Kano, A Kurushima, Tetsuya Kitagawa, T Iwase, Masashi Akaike, M Abe and Toshio Matsumoto :
Erythropoietin induced peripheral stem cell transplantation for severe ischemic limbs,
The 14th Annual Meeting of the Asian Society for Cardiovascular Surgery, Osaka, Jun. 2006. Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Hirotsugu Kurobe, Fujimura Mitsunori, Shusuke Yagi, Hashizume Shunji, Yasumasa Ikeda, Takashi Iwase, Takamori Nobuyuki, Tetsuya Kitagawa and Toshio Matsumoto :
Plasma Heparin Cofactor II Activity is a Predictor for Incidence of Peripheral Arterial Disease in Patients with Cardiovascular Risk Factors,
XIV International Symposium on Atherosclerosis, 2006 Rome, Italy, Jun. 2006. Ken-ichi Aihara, Mihara Masatomo, Hiroyuki Azuma, Masashi Akaike, Takaya Matsushita, Yasumasa Ikeda, Shusuke Yagi, Takashi Iwase, Hashizume Shunji, Fujimura Mitsunori and Toshio Matsumoto :
Argatroban, a synthetic thrombin antagonist, can reduce insulin resistance though thrombin inactivation in the db/db mouse model of type 2 diabetes mellitus,
XIV International Symposium on Atherosclerosis, 2006 Rome, Italy, Jun. 2006. Hirotsugu Kurobe, Yuki Izawa, Yayoi Fukuhara, Tamotsu Kanbara, Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma, Tetsuya Kitagawa, Toshiaki Tamaki, Toshio Matsumoto, Masaki Ueno, Shuhei Tomita and Masanori Yoshizumi :
T Cell-specific HIF-1α-deficient Mice, but Not ARNT-deficient Mice, Exhibit Exacerbated Inflammation and Vascular Remodeling in Response to Cuff Injury,
American Heart Association 2005 Scientifc Sessions, Dallas, Nov. 2005. Takamori Nobuyuki, Masashi Akaike, Ken-ichi Aihara, Hirono Akira, Yamaguchi Hiroshi, Hiroyuki Azuma, Tamura Katsuya and Toshio Matsumoto :
Plasma Heparin Cofactor II Activities Predict Cardiovascular Risk in Patients with Coronary Heart Disease,
American Heart Associations Scientific Sessions 2005, Dallas, USA, Nov. 2005. Ken-ichi Aihara, Takamori Nobuyuki, Yasuhiko Kanagawa, Masashi Akaike, Fujimura Mitsunori, Yoshida Tomonori, Hashizume Shunji, Kato Midori, Yasumasa Ikeda, Hiroyuki Azuma and Toshio Matsumoto :
Heparin cofactor II is inversely related to the severity of carotid atherosclerosis,
American Heart Association, Scientific Sessions 2003 Orland Florida USA, Nov. 2003. 八木秀介, 坂東遼, 山口浩司, 添木武, 赤池雅史, 若槻哲三, 佐田政隆 :
腎血管性高血圧を合併した左室駆出率の保たれた心不全の1例,
第130回日本内科学会四国地方会, 2024年6月. 八木秀介, 添木武, 赤池雅史, 佐田政隆 :
高血圧患者における塩分摂取量の特徴の検討,
第130回日本内科学会四国地方会, 2024年6月. 冨田江一, 平山晃斉, 梅嶋宏樹, 常山幸一, 西村明儒, 主田英之, 赤池雅史, 滝沢宏光, 島田光生, 髙木康志, 橋本一郎, 岩田貴 :
徳島大学医学部の系統解剖実習における画像診断技術・病理診断技術・外科的手術手技を取り入れた垂直連携教育の実践,
第129回日本解剖学会全国学術集会, 2024年3月. Masashi Akaike :
徳島大学・モンゴル医科大学協定校契約とJICA プログラム,
第59回日本医学放射線学会秋季臨床大会, Sep. 2023. 西田憲生, 常山幸一, 赤池雅史 :
医学科1年次における垂直統合型の早期体験実習の試み,
第55回日本医学教育学会大会, 2023年7月. 金山博臣, 赤池雅史, 冨田江一, 鶴尾吉宏, 西村明儒, 西良浩一, 和田佳三 :
徳島大学病院クリニカルアナトミー教育・研究センターの現状と展望,
第128回日本解剖学会総会・全国学術集会, 2023年3月. Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, TOMONORI Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels,
第87回日本循環器学会学術集会, Mar. 2023. 藤川理恵, 高開登茂子, 久米博子, 三木幸代, 原田路可, 加根千賀子, 赤池雅史, 楊河宏章, 苛原稔 :
モンゴル国 A 病院のモンゴル人看護師のリスク感性の分析,
第53回日本看護学会学術集会, 2022年11月. 長宗雅美, 吾妻雅彦, 岩田貴, 赤池雅史 :
医療系専門職連携教育におけるオンラインワークショップの試み,
第17回大学教育カンファレンスin徳島, 2022年1月. 青木理紗, 髙田真里菜, 篠島理, 西川美佳, 大塚拓, 藤原茂樹, 江口覚, 長宗雅美, 赤池雅史, 高石和美, 北畑洋 :
気管挿管手技における気道管理シミュレータ4種類の比較,
第49回日本歯科麻酔学会総会・学術集会, 2021年10月. 西田憲生, 清水真祐子, 吾妻雅彦, 常山幸一, 赤池雅史 :
オンラインPBLチュートリアルの実施から見えてきた課題,
第53回日本医学教育学会大会, 2021年7月. 西田憲生, 清水真祐子, 常山幸一, 赤池雅史 :
オンラインPBLチュートリアルの実施報告ならびにその効果と課題,
大学教育カンファレンスin徳島, 2021年1月. 八木秀介, 粟飯原賢一, 吉田守美子, 池田康将, 赤池雅史, 佐田政隆 :
心血管病における性機能障害と男性ホルモンの心血管保護作用,
日本性機能学会第30回学術集会,シンポジウム, 2019年9月. 吾妻雅彦, 長宗雅美, 岩田貴, 西岡安彦, 赤池雅史 :
電子聴診器を用いた呼吸音聴診教育についての取り組み,
第51回日本医学教育学会大会, 2019年7月. 岩田貴, 島田光生, 吾妻雅彦, 長宗雅美, 赤池雅史 :
VR+AR実習は学生の腹腔鏡模擬手術実習における局所解剖理解に有用である,
第51回日本医学教育学会大会, 2019年7月. 吉田光輝, 岩田貴, 赤池雅史, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章, 鶴尾吉宏 :
《ワークショップ》外科手術教育の当院における取り組み,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 谷彰浩, 楠瀬賢也, 松本和久, 松浦朋美, 伊勢孝之, 飛梅威, 山口浩司, 八木秀介, 福田大受, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張期僧帽弁逆流の治療適応判断に心房心室同時ペーシングが有効であった1例,
第114回日本循環器学会中国・四国合同地方会, 2019年6月. 植野美彦, 関陽介, 赤池雅史, 野間口雅子 :
教育連動型AO入試の設計と実施ー地方国立大学における研究医の養成・確保をめざしてー,
令和元年度全国大学入学者選抜研究連絡協議会大会(第14回) 招待研究会, 2019年5月. 赤池雅史 :
四国での専門医研修について語る,
第113回日本循環器学会四国地方会ダイバーシティシンポジウム, 2018年12月. 岩田貴, 長宗雅美, 吾妻雅彦, 島田光生, 赤池雅史 :
クリニカル・クラークシップでの手技実習の質的評価としてのルーブリック評価の有用性の検討,
第50回日本医学教育学会大会, 2018年8月. 三笠洋明, 赤池雅史, 西村明儒 :
医療系学部におけるアクティブラーニングの実施状況と満足度および自学自修時間との関係,
第50回日本医学教育学会大会, 2018年8月. Yamada Yoshiko, Yada Keigo, Hiroyuki Nodera, Koichi Sairyo, Masashi Akaike and Akiyoshi Nishimura :
Effectiveness of the medical English course taught by an all-Japanese clinician team,
第21回日本医学英語教育学会, Jul. 2018. 岩田貴, 島田光生, 東島潤, 徳永卓哉, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 赤池雅史 :
腹腔鏡トレーニングの質的評価としてのルーブリック評価の有用性の検討,
第118回日本外科学会定期学術集会, 2018年4月. 八木秀介, 伊勢孝之, 川端豊, 伊藤浩敬, 楠瀬賢也, 山口浩司, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
経カテーテル大動脈弁植込み術を施した超高齢大動脈弁狭窄症の1例,
日本老年医学会四国地方会, 2018年2月. 轟貴史, 八木秀介, 楠瀬賢也, 伊勢孝之, 西條良仁, 瀬野弘光, 廣野明, 松浦朋美, 福田大受, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
膠原病患者での肺動脈楔入圧と左室拡張期末期圧の関係,
第65回日本心臓病学会学術集会, 2017年9月. 赤池雅史 :
多職種連携教育で推進する医療教育学,
第6回日本栄養学教育学会学術総会, 2017年9月. 吾妻雅彦, 長宗雅美, 岩田貴, 川添和義, 石澤啓介, 竹谷豊, 西岡安彦, 赤池雅史 :
徳島大学における担当患者を用いた多職種連携教育の取り組み,
第49回日本医学教育学会大会, 2017年8月. 三笠洋明, 赤池雅史, 西村明儒 :
学生の視点に基づいた授業改善の実践とその成果,
第49回日本医学教育学会大会, 2017年8月. 岩田貴, 島田光生, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 長宗雅美, 赤池雅史 :
腹腔鏡下ペグタッチトレーニングの自学実習を目指したシミュレータの開発,
第49回日本医学教育学会大会, 2017年8月. 吉田光輝, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野恒作, 鶴尾吉宏 :
鏡視下手術時代の教育の開発未固定遺体を用いた胸腔鏡手術トレーニングの経験,
第42回日本外科系連合学会学術集会, 2017年6月. 吉田光輝, 滝沢宏光, 吉田卓弘, 坪井光弘, 河北直也, 澤田徹, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野耕作, 鶴尾吉宏 :
《考える外科学》未固定遺体とのシミュレーションを用いた新たな実践型内視鏡下低侵襲手術トレーニングプログラムの構築,
第117回日本外科学会定期学術集会, 2017年4月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 西正暁, 柏原秀也, 髙須千絵, 石川大地, 赤池雅史 :
腹腔鏡下eye hand coordinationトレーニングの自学実習を目指したシミュレータの開発,
第117回日本外科学会定期学術集会, 2017年4月. 轟貴史, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takayuki Ise, Tomomi Matsuura, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Serum Level of Lipoprotein (a) is a Risk Factor for Aortic Valve Sclerosis in Women,
第81回日本循環器学会学術集会, Mar. 2017. 山本清成, 轟貴史, 大櫛祐一郎, 上野理恵, 伊勢孝之, 瀬野弘光, 西條良仁, 高木恵理, 原知也, 川端豊, 斎藤友子, 伊藤浩敬, 松浦朋美, 飛梅威, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 門田友里, 西村正人, 苛原稔 :
PET/CTにて診断できた心サルコイドーシスの1例,
第254回徳島医学会学術集会, 2017年2月. 八木秀介, 伊勢孝之, 西川幸治, 石井亜由美, 楠瀬賢也, 山口浩司, 松浦朋美, 飛梅威, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全患者に対するAdaptive servo-ventilation装着下6分間歩行における運動耐容能改善効果,
第64回日本心臓病学会学術集会, 2016年9月. 岩田貴, 赤池雅史, 吾妻雅彦, 長宗雅美 :
医療系学部中・高学年に対する他職種連携PBLチュートリアル授業の試み,
第48回日本医学教育学会大会, 2016年7月. 赤池雅史, 三笠洋明, 西村明儒 :
診療参加型臨床実習における学生の満足度と学修到達度の規定因子,
第48回日本医学教育学会大会, 2016年7月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 髙須千絵, 赤池雅史 :
若手外科医育成のための卒然教育からの工夫∼移植シンポの早期体験と反転授業を応用した実習の試み∼.,
第71回日本消化器外科学会総会, 2016年7月. 松浦一義, 山田博胤, 楠瀬賢也, 鈴川理乃, 平田有紀奈, 山尾雅美, 西尾進, 赤池雅史, 佐田政隆 :
医学生の心エコー実習におけるシミュレーター教育の効果,
日本超音波医学会第89回学術集会, 2016年5月. 八木秀介, 西條良仁, 高川由利子, 赤池雅史, 佐田政隆, 近藤剛史, 吉田守美子, 遠藤逸朗, 粟飯原賢一 :
左副腎に腫瘤を認めた両側性特発性アルドステロン症の1例,
日本内科学会第114回四国地方会, 2016年5月. 赤池雅史 :
Current Status and Issues of Clinical Clerkship in Undergraduate Medical Education in Japan - Analysis of Students Satisfaction -,
第80回日本循環器学会学術集会会長特別企画 10「日米の医学教育を考える」, 2016年3月. Shusuke Yagi, Ken-ichi Aihara, Daiju Fukuda, A Takashima, Mika Bando, T Hara, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike and Masataka Sata :
Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.,
第80回日本循環器学会学術集会, Mar. 2016. Shusuke Yagi, Ken-ichi Aihara, Masashi Akaike, T Hara, Takayuki Ise, Daiju Fukuda, Michio Shimabukuro and Masataka Sata :
Modulation of Tissue Thrombin Action is a Novel Therapeutic Approach for Prevention of Polyvascular Disease.,
第80回日本循環器学会学術集会, Mar. 2016. 近藤大祐, 八木秀介, 伊勢孝之, 山口浩司, 若槻哲三, 楠瀬賢也, 松浦朋美, 飛梅威, 山田博胤, 添木武, 福田大受, 赤池雅史, 島袋充生, 佐田政隆 :
急性冠症候群発症時のイコサペント酸とドコサヘキサエン酸の血中濃度低下は慢性期冠動脈ステント内再狭窄の予測因子である,
第45回日本心脈管作動物質学会, 2016年2月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生 :
臨床実習での技能トレーニングにおける反転授業の効果,
大学教育カンファレンスin徳島, 2016年1月. 三笠洋明, 赤池雅史, 西村明儒 :
共通教育課程における留年のリスクファクターに関する研究,
大学教育カンファレンスin徳島, 2016年1月. 粟飯原賢一, 赤池雅史, 吉田守美子, 松本俊夫 :
グルココルコイド過剰誘導酸化ストレスの臨床的評価とeNOSの有無におけるピタバスタチンの虚血臓器保護効果機構の差異,
平成27年度第1回班会議, 2015年12月. 白川光雄, 本田壮一, 松田啓次, 折野真哉, 坂東弘康, 赤池雅史 :
徳島県海部郡医療方言用語集作成の試み,
第15回日本プライマリ・ケア連合学会四国支部学術集会, 2015年11月. 赤池雅史 :
医療教育の充実と看護教育への期待,
日本看護学教育学会第25回学術集会教育講演Ⅱ, 2015年8月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生 :
鏡視下手技が苦手な学生に対するoff-the-jobトレーニングの工夫,
第251回徳島医学会学術集会, 2015年8月. 三笠洋明, 赤池雅史, 西村明儒 :
講義の反転授業化により学生の自学自習は促進されるか,
第47回日本医学教育学会大会, 2015年7月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生 :
クリニカルクラークシップ学生対象の反転授業応用縫合実習の試み,
第47回日本医学教育学会大会, 2015年7月. 西晃, 村山美咲, 赤池雅史 :
ぬいぐるみ病院活動が参加学生に及ぼす教育的効果に関する検討,
第47回日本医学教育学会大会, 2015年7月. 山田佳子, Bukasa Kalubi, Masashi Akaike and Akiyoshi Nishimura :
Improving doctor-patient communication in extracurricular activities,
第18回日本医学英語教育学会, Jul. 2015. 八木秀介, 伊勢孝之, 西川幸治, 石井亜由美, 高川由利子, 岩瀬俊, 赤池雅史, 加藤真介, 佐田政隆 :
重症心不全患者におけるAdaptive servo-ventilation装着による運動耐容能改善効果,
第21回日本心臓リハビリテーション学会, 2015年7月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 徳永卓哉, 髙須千絵, 江藤祥平, 赤池雅史 :
内視鏡手術時代における卒前教育からのoff-the-jobと反転授業を応用した実習の試み,
第70回日本消化器外科学会総会, 2015年7月. 赤池雅史 :
確かな学力による，確かな実力―能動的学習について―,
第63回中国・四国地区大学教育研究会, 2015年6月. 池田康将, 粟飯原賢一, 吉田守美子, 赤池雅史, 玉置俊晃, 松本俊夫 :
心血管疾患における男性ホルモンの意義,
第15回日本抗加齢医学会総会シンポジウム「知って得するテストステロンアップデート」, 2015年5月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 徳永卓哉, 髙須千絵, 赤池雅史 :
鏡視下手技が苦手な学生をどうトレーニングするか?―off-the-job トレーニングの工夫―,
第115回日本外科学会定期学術集会, 2015年4月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生 :
反転授業を応用したクリニカルクラークシップ学生対象の縫合実習の試み,
第250回徳島医学会学術集会, 2015年2月. 本田壮一, 谷憲治, 白川光雄, 橋本崇代, 小原聡彦, 赤池雅史, 吉本勝彦 :
医学生実習を受け入れて(第2報),
第250回徳島医学会学術集会, 2015年2月. 三笠洋明, 赤池雅史, 西村明儒 :
授業のアクティブラーニング化は学生の自学自習を促進するかー反転授業の場合―,
大学教育カンファレンスin徳島大学, 2014年12月. 長宗雅美, 岩田貴, 辻暁子, 石田加寿子, 東瞳, 赤池雅史 :
医療系学科1年生合同ワークショップの効果的実践∼8年間の振り返りより,
大学教育カンファレンスin徳島大学, 2014年12月. 今田久美子, 伊勢孝之, 八木秀介, 高木恵理, 松本和久, 高川由利子, 原知也, 高島啓, 齋藤友子, 坂東美佳, 山﨑宙, 坂東左知子, 松浦朋美, 飛梅威, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性血栓塞栓性肺高血圧症にリオシグアトを使用した1症例,
第105回日本循環器学会四国地方会, 2014年12月. 石井亜由美, 西川幸治, 伊勢孝之, 高川由利子, 八木秀介, 岩瀬俊, 木下肇, 阪田美穂, 早渕康信, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 :
単心室症患児の開心術後に心臓リハビリテーションを有効に施行し得た一例,
第105回日本循環器学会四国地方会, 2014年12月. 八木秀介, 鳥居祐太, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
突然の片側性下肢腫脹を呈した変形性関節症の2例,
第105回日本循環器学会四国地方会, 2014年12月. 稲垣太造, 八木秀介, 伊勢孝之, 山口浩司, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 佐田政隆 :
治療抵抗性本態性高血圧に対する利尿剤の効果-インダパミドが効果的であった2例の検討-,
第105回日本循環器学会四国地方会, 2014年12月. 赤池雅史 :
これからの医学教育∼総合診療への期待∼,
第14回日本PC連合学会四国ブロック支部/第21回四国地域医学研究会学術集会・合同集会ミニレクチャー, 2014年11月. 八木秀介, 粟飯原賢一, 赤池雅史, 添木武, 佐田政隆 :
血清PTH濃度は高血圧の発症と関連する,
第37回日本高血圧学会総会, 2014年10月. 岩田貴, 島田光生, 吉川幸造, 東島潤, 西正暁, 徳永卓哉, 髙須千絵, 江藤祥平, 中尾寿宏, 赤池雅史 :
内視鏡外科手術におけるOff-the-jobトレーニングを科学する,
第27回日本内視鏡外科学会総会, 2014年10月.

(キーワード): 国内学会

Yosuke Sakai, Bukasa Kalubi, Masashi Akaike and A. Nishimura :
Enhancing English communication skills through a students-run English-only extracurricular activity,
Journal of Medical English Education, Vol.13, No.2, 38, Jul. 2014. Bukasa Kalubi, Omar Maningo Rodis, Masashi Akaike and Kiyoshi Fukui :
Communication Know-how course: A practical approach to improving professional communication skills in graduate and post-graduate education,
17th JASMEE Academic Meeting, Jul. 2014. 西川幸治, 石井亜由美, 後藤強, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 加藤真介, 佐田政隆 :
運動習慣の有無が運動耐用能および動脈機能の関係に及ぼす影響について,
第20回日本心臓リハビリテーション学会学術集会, 2014年7月. 石井亜由美, 八木秀介, 西川幸治, 後藤強, 伊勢孝之, 岩瀬俊, 赤池雅史, 加藤真介, 佐田政隆 :
心臓リハビリテーション実施期間中の体重増加が運動耐容能におよぼす影響,
第20回日本心臓リハビリテーション学会学術集会, 2014年7月. 長宗雅美, 岩田貴, 福富美紀, 赤池雅史 :
医学生に必要な医療コミュニケーション能力―臨床実習前教育とクリニカルクラークシップとのギャップー,
第46回日本医学教育学会大会, 2014年7月. 今田久美子, 伊勢孝之, 原知也, 八木秀介, 岩瀬俊, 西條良仁, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心不全を合併した頻脈性心房細動にランジオロールを有効に使用することができた2症例,
第104回日本循環器学会中国・四国合同地方会, 2014年7月. 粟飯原賢一, 吉田守美子, 池田康将, 上元良子, 石川カズ江, 赤池雅史, 松本俊夫 :
動脈硬化および虚血に対するeNOS非依存的なピタバスタチンの臓器保護効果の検討,
第46回日本動脈硬化学会総会・学術集会, 2014年7月. 本田壮一, 小原聡彦, 谷憲治, 白川光雄, 赤池雅史, 吉本勝彦 :
医学生実習を受け入れて-5年間の経験よりー,
第110回日本内科学会四国地区支部主催四国地方会徳島, 2014年6月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 西正暁, 近清素也, 髙須千絵, 柏原秀也, 松本規子, 赤池雅史 :
大学と関連病院が連携した若手医師の研修プログラム構築―地方からの提言―,
第114回日本外科学会定期学術集会, 2014年4月.

(キーワード): 国内学会

Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, A Takashima, Mika Bando, S Bando, T Matsuura, Junko Hotsuchi, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Impact of cardiac rehabilitation on oxidized stress in patients with heart failure.,
第78回日本循環器学会学術集会, Mar. 2014. 石澤有紀, Le Nhat-Tu, 竹井雄一郎, Heo Kyung-Sun, Lee Hakjoo, Smrcka Alan, Miller Benjamin, Ko Kyung-Ae, Ture Sara, Morrell Craig, 藤原敬己, 赤池雅史, 玉置俊晃, 阿部純一 :
内皮細胞におけるERK5活性化を介したスタチン・抗マラリア薬の抗炎症作用の検討,
第87回日本薬理学会年会, 2014年3月. 長宗雅美, 岩田貴, 福富美紀, 赤池雅史 :
臨床実習における医学生のコミュニケーションの現状,
第248回徳島医学会学術集会, 2014年2月. 宮本登志子, 明石晃代, 楊河宏章, 赤池雅史, 他, 木田菊枝, 近藤佐地子 :
CRCの人材育成の試み-院内キャリア形成支援センター・看護部との連携モデル-,
第248回徳島医学会学術集会, 2014年2月. 今田久美子, 八木秀介, 山口浩司, 若槻哲三, 伊勢孝之, 太田理絵, 門田宗之, 高島啓, 松浦朋美, 飛梅威, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
心不全を合併した腎血管性高血圧に対する経皮的腎動脈形成術の有効性,
第248回徳島医学会学術集会, 2014年2月. 八木秀介, 粟飯原賢一, 赤池雅史, 松本幸子, 福田大受, 松浦朋美, 伊勢孝之, 山口浩司, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 島袋充生, 松本俊夫, 佐田政隆 :
DPP-4阻害薬の血糖降下作用に対する有効性予測因子,
第248回徳島医学会学術集会, 2014年2月. 岩田貴, 赤池雅史, 長宗雅美, 福富美紀, 島田光生 :
海外交流体験実習を利用したスキルスラボでのグローバルスキルトレーニング,
第248回徳島医学会学術集会(平成25年度冬期), 2014年2月. 赤池雅史 :
学生教育環境における病院情報システム機能と運用,
大学病院情報マネジメント部門連絡会議, 2014年2月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生 :
反転授業を応用したクリニカルクラークシップ学生対象の縫合実習の試み,
第250回徳島医学会学術集会, 2014年2月.

(キーワード): 国内学会

長宗雅美, 岩田貴, 福富美紀, 赤池雅史 :
医療系学生は医療コミュニケーションをどこで学んでいるか,
大学教育カンファレンスin徳島, 2013年12月. 岩田貴, 福富美紀, 長宗雅美, 赤池雅史 :
スキルス・ラボにおける海外交流トレーニング,
大学教育カンファレンスin徳島, 2013年12月. 發知淳子, 山田博胤, 原知也, 太田理絵, 高島啓, 坂東美佳, 小笠原梢, 坂東左知子, 松浦朋美, 伊勢孝之, 木村恵理子, 飛梅威, 山口浩司, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷の効果があった薬剤抵抗性起立性低血圧の2症例,
第103回日本循環器学会四国地方会, 2013年12月. 石井亜由美, 西川幸治, 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 西條良仁, 高島啓, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 中山泰介, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 :
人工呼吸管理中の心不全症例に心臓リハビリテーションが有効に施行しえた症例,
第103回日本循環器学会四国地方会, 2013年12月. 伊勢孝之, 八木秀介, 岩瀬俊, 西條良仁, 高木恵理, 太田理絵, 門田宗之, 原知也, 小笠原梢, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
当院でのAdaptive-Servo Ventilationが有効であった拡張障害心不全の症例検討,
第103回日本循環器学会四国地方会, 2013年12月. 宮本登志子, 明石晃代, 田島壮一郎, 天羽亜美, 大和志保, 吉丸倫子, 小杉千里, 楊河宏章, 赤池雅史, 木田菊枝, 近藤佐地子 :
CRCの人材育成の試み-院内キャリア形成支援センター・看護部との連携モデル-,
第34回日本臨床薬理学会年会, 2013年12月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 柏原秀也, 松本規子, 徳永卓哉, 赤池雅史 :
腹腔鏡下手術トレーニングボックスを用いた鏡視下手術手技理解促進のための基礎的検討,
第26回日本内視鏡外科学会総会, 2013年11月. Takayuki Ise, Takashi Iwase, Hirotsugu Yamada, Shusuke Yagi, Takeshi Tobiume, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Progression of a Case of Myocardial Damage Caused by Beckers Muscular Dystrophy.,
第17回日本心不全学会学術集会, Nov. 2013. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 吉川幸造, 東島潤, 西正暁, 近清素也, 徳永卓哉, 松本規子, 赤池雅史 :
開腹手術は内視鏡下手術トレーニングに必要である∼鏡視下手術理解促進のための基礎的検討∼,
第75回日本臨床外科学会総会, 2013年11月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 原知也, 太田理絵, 坂東美佳, 高島啓, 坂東左知子, 松浦朋美, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
慢性心不全患者に対するトルバプタン投与における薬物血中濃度と利尿効果の検討,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 赤池雅史, 西尾進, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
Intramural Hematoma症例のUlcer Like Projection形成と拡大における穿通枝の重要性,
第61回日本心臓病学会学術集会, 2013年9月. 伊勢孝之, 岩瀬俊, 山田博胤, 坂東美佳, 西尾進, 山口浩司, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Becker型筋ジストロフィーによる心筋障害の経過を観察し得た1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 太田理絵, 山口浩司, 赤池雅史, 伊勢孝之, 山田博胤, 添木武, 若槻哲三, 原田雅史, 佐田政隆 :
3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例,
第61回日本心臓病学会学術集会, 2013年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 伊勢孝之, 八木秀介, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性,
第61回日本心臓病学会学術集会, 2013年9月. 岩田貴, 赤池雅史, 長宗雅美, 福富美紀, 島田光生 :
腹腔鏡下手術トレーニングボックスを用いた鏡視下手術手技理解促進のための基礎的検討,
第247回徳島医学会学術集会(平成25年度夏期), 2013年8月. 門田宗之, 伊勢孝之, 八木秀介, 岩瀬俊, 太田理絵, 原知也, 高島啓, 坂東美佳, 坂東左知子, 松浦朋美, 發知淳子, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史 :
慢性心不全における新規利尿薬tolvaptanの効果予測因子,
第247回徳島医学会学術集会, 2013年8月. 石井亜由美, 西川幸治, 加藤真介, 伊勢孝之, 八木秀介, 岩瀬俊, 上田由佳, 門田宗之, 高島啓, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 中川泰介, 北川哲也, 赤池雅史 :
人工呼吸管理中に心臓リハビリを有効に施行しえた開心術後の心不全症例,
第247回徳島医学会学術集会, 2013年8月. 岩田貴, 島田光生, 長宗雅美, 福富美紀, 赤池雅史 :
システム，支援，フィードバックに着眼した腹腔鏡下手術トレーニング,
第45回日本医学教育学会大会, 2013年7月. 赤池雅史, 三笠洋明, 西村明儒 :
臨床医学の教育業績評価,
第45回日本医学教育学会大会, 2013年7月. 三笠洋明, 赤池雅史, 西村明儒 :
ルーブリック評価を活用した項目特性分析による記述式試験問題の評価,
第45回日本医学教育学会大会, 2013年7月. 長宗雅美, 岩田貴, 福富美紀, 石田加寿子, 赤池雅史 :
OSCEにおける模擬患者演技の均一化を目標としたトレーニングの方策,
第45回日本医学教育学会大会, 2013年7月. 福富美紀, 岩田貴, 長宗雅美, 赤池雅史 :
スキルスラボを活用した高校生医学体験実習の卒後進路に及ぼす影響,
第45回日本医学教育学会大会, 2013年7月. 岩田貴, 赤池雅史, 長宗雅美, 福富美紀, 島田光生 :
腹腔鏡下手術トレーニングボックスを用いた鏡視下手術手技理解促進のための基礎的検討,
第1回日本シミュレーション医療教育学会大会, 2013年7月. 平田有紀奈, 西尾進, 友藤達陽, 坂東美佳, 林修司, 發知淳子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
超音波検査で計側した各種脂肪組織厚と冠動脈硬化症との関連,
第86回日本超音波医学会学術集会, 2013年5月. 幸田舞子, 伊勢孝之, 川端豊, 門田宗之, 原知也, 太田理絵, 坂東美佳, 坂東左知子, 松浦朋美, 仁木敏之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 竹谷善雄, 山田博胤, 赤池雅史, 林友鴻, 長谷川拓也, 佐田政隆 :
経皮的中隔心筋焼灼術が奏功した閉塞性肥大型心筋症の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 岩瀬俊, 山田博胤, 川端豊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 八木秀介, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心病変の経過を観察し得たBecker型筋ジストロフィーによる心不全の1例,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 伊勢孝之, 八木秀介, 岩瀬俊, 門田宗之, 仁木敏之, 坂東美佳, 坂東左知子, 松浦朋美, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
慢性心不全におけるAdaptive-Servo Ventilationの血行動態に対する効果,
第102回日本循環器学会中国・四国合同地方会, 2013年5月. 吉田守美子, 粟飯原賢一, 池田康将, 盛真友, 松本高広, 赤池雅史, 佐田政隆, 松本俊夫 :
アンドロゲン受容体は性差非依存的にVEGF受容体を介して虚血反応性血管新生を促進する,
第86回日本内分泌学会学術総会, 2013年4月. 粟飯原賢一, 吉田守美子, 上元良子, 石川カズ江, 赤池雅史, 松本俊夫 :
重症下肢虚血壊死に対するピタバスタチンの組織保護効果に関する検討,
第86回日本内分泌学会学術総会, 2013年4月. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. Takayuki Ise, Takashi Iwase, Shoichiro Takao, M Kadota, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Shusuke Yagi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masafumi Harada and Masataka Sata :
Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis.,
第77回日本循環器学会学術集会, Mar. 2013. Shusuke Yagi, Takayuki Ise, Hirotsugu Yamada, S Nishio, Yuka Ueda, Takashi Iwase, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia.,
第77回日本循環器学会学術集会, Mar. 2013. Takashi Iwase, Shoichiro Takao, Masashi Akaike, Takayuki Ise, Toshiyuki Niki, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Ken-ichi Aihara, Tetsuzo Wakatsuki, Yasuhiko Nishioka, Masafumi Harada and Masataka Sata :
Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance.,
第77回日本循環器学会学術集会, Mar. 2013. M Kadota, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Masashi Akaike, R Ota, Y Kawabata, T Hara, K Ogasawara, Mika Bando, S Bando, T Matsuura, Toshiyuki Niki, J Hotchi, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure.,
第77回日本循環器学会学術集会, Mar. 2013. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, M Takeuchi :
再熱と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. M Koda, 佐田政隆, 伊勢孝之, Y Kawabata, 岩瀬俊, M Kadota, T Hara, R Ota, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, S Okazaki, 林友鴻, T Hasegawa :
難治性の閉塞性肥大型心筋症に対して経皮的中隔心筋焼灼術が著効した1例,
第246回徳島医学会学術集会(平成24年度冬期), 2013年2月. 上田由佳, 伊勢孝之, 岩瀬俊, K Maeda, K Nishikawa, M Kadota, T Hara, Y Kawabata, R Ota, 仁木敏之, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
心臓リハビリテーションにおける禁煙継続効果の検討,
第101回日本循環器学会四国地方会, 2012年12月. Y Kawabata, 伊勢孝之, T Matsuura, S Bando, 岩瀬俊, K Ogasawara, 坂東美佳, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度肥満を伴った拡張型心筋症の1例,
第101回日本循環器学会四国地方会, 2012年12月. S Sakamoto, M Kadota, 伊勢孝之, 岩瀬俊, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 八木秀介, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
再燃と寛解を繰り返す特発性心膜炎に対しイブプロフェンが有効であった1例,
第101回日本循環器学会四国地方会, 2012年12月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵, 松本規子, 赤池雅史 :
システム，支援，フィードバックに注目した内視鏡下手術トレーニング,
第25回日本内視鏡外科学会総会, 2012年12月.

(キーワード): 国内学会

M Kadota, Takayuki Ise, Takashi Iwase, Masashi Akaike, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Takeshi Soeki and Masataka Sata :
Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. Takayuki Ise, Shusuke Yagi, Masashi Akaike, Takashi Iwase, M Kadota, T Hara, Koji Yamaguchi, Yoshio Taketani, Tetsuzo Wakatsuki and Masataka Sata :
Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Heart Failure.,
第16回日本心不全学会学術集会, Nov. 2012. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵, 赤池雅史 :
最良の外科医の教育とは何か∼システム，支援，フィードバックに着眼した教育∼,
第74回日本臨床外科学会総会, 2012年11月.

(キーワード): 国内学会

伊勢孝之, 岩瀬俊, K Nanjo, 髙尾正一郎, R Ota, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
心臓MRIを用いた左室肥大患者における右室壁厚の検討,
第60回日本心臓病学会学術集会, 2012年9月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵, 松本規子, 赤池雅史 :
腹腔鏡下胃切除術のトレーニングにおける開腹術からのフィードバックの有用性について,
第17回中国四国内視鏡外科研究会, 2012年9月. Y Yokota, M Kadota, 伊勢孝之, 岩瀬俊, T Hara, R Ota, Y Kawabata, K Ogasawara, 坂東美佳, S Bando, T Matsuura, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 江川麻理子, 三田村佳典 :
眼病変の経過中に心室中隔の肥厚および完全房室ブロックで発症した心サルコイドーシスの一例,
第245回徳島医学会学術集会(平成24年度夏期), 2012年7月. 岩田貴, 島田光生, 長宗雅美, 赤池雅史 :
腹腔鏡下胃切除術の術者研修中における開腹術からのフィードバックの有用性について,
第44回日本医学教育学会大会, 2012年7月. 三笠洋明, 赤池雅史, 西村明儒, 福井義浩 :
共用試験OSCEによる臨床実習前教育の評価:項目特性曲線による評価方法,
第44回日本医学教育学会大会, 2012年7月. 上田由佳, 岩瀬俊, 伊勢孝之, K Maeda, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
喫煙継続者における心臓リハビリテーションの効果の検討,
第18回心臓リハビリテーション学会, 2012年7月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
患者の気持ちを汲んだ患者教育の実際,
第18回心臓リハビリテーション学会, 2012年7月. A Takashima, 伊勢孝之, 上田由佳, K Maeda, K Nishikawa, K Ogasawara, 坂東美佳, N Tomita, 仁木敏之, J Hotchi, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 加藤真介, 赤池雅史, 安井夏生, 佐田政隆 :
心臓リハビリテーションは酸化LDLを低下させる,
第18回心臓リハビリテーション学会, 2012年7月. A Tachibana, 伊勢孝之, 添木武, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
CRT-Dが著効した重症拡張型心筋症の2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Nagasaka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
マルチモダリティを用いて鑑別し得た冠動脈病変合併たこつぼ型心筋症の1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, K Nanjo, 岩瀬俊, 髙尾正一郎, R Ota, M Kadota, T Hara, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 原田雅史, 佐田政隆 :
左室肥大患者における右室壁厚の検討,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, A Takashima, H Yamasaki, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Adaptive Servo-Ventilationが心不全治療に有効であった心アミロイドーシスの2症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. K Maeda, 上田由佳, 伊勢孝之, 岩瀬俊, K Nishikawa, 坂東美佳, K Ogasawara, S Bando, 仁木敏之, J Hotchi, 山口浩司, N Tomita, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 加藤真介, 安井夏生, 佐田政隆 :
チーム医療で取り組む重症心不全に対する心臓リハビリテーション,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. S Taoka, 伊勢孝之, 岩瀬俊, R Ota, M Kadota, T Hara, K Ogasawara, 坂東美佳, S Bando, 仁木敏之, J Hotchi, N Tomita, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
テニスラケットによる打撲が誘引で深部静脈血栓・急性肺塞栓症を来した1症例,
第100回日本循環器学会中国・四国合同地方会, 2012年6月. 鶴尾美穂, 寺澤敏秀, 木戸里佳, 吉田守美子, 湯浅智之, 近藤剛史, 笠松哲司, 近藤絵里, 木内美瑞穂, 黒田暁生, 松久宗英, 松本俊夫, 赤池雅史 :
粥状動脈硬化病変を呈した高Lp(a)血症合併糖尿病の姉妹例,
第55回日本糖尿病学会年次学術集会, 2012年5月. 吉田守美子, 粟飯原賢一, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
エイコサペントエン酸は酸化ストレス抑制を介して心臓リモデリングを抑制する,
日本高血圧学会第1回臨床高血圧フォーラム, 2012年5月.

(キーワード): *Eicosapentaenoic Acid(薬理学,治療的利用) 疾患モデル(動物) *心臓血管疾患(超音波診断,病理学,予防) *酸化ストレス BALB Cマウス *心室リモデリング(予防) ヒトマウス動物男女

粟飯原賢一, 吉田守美子, 赤池雅史, 松本俊夫 :
血管内皮機能制御における血圧関連指標の意義,
日本高血圧学会第1回臨床高血圧フォーラム, 2012年5月. 赤池雅史 :
ステロイドによる血管内皮細胞障害と骨壊死の関係,
第56回日本リウマチ学会総会・学術集会, 2012年4月. Munkbaatar Dagvasumberel, 島袋充生, Nishiuchi Takeshi, Hirata Yoichiro, 添木武, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 八木秀介, Tomita Noriko, 山田博胤, 若槻哲三, 黒部裕嗣, 北川哲也, 佐田政隆 :
Gender Disparities in Association of Epicardial Adipose Tissue Volume and Coronary Atherosclerosis.,
第76回日本循環器学会学術集会, 2012年3月. Kimura Sahika, 上田由佳, 伊勢孝之, 岩瀬俊, Takashima Akira, Yamazaki Hiromu, Ogasawara Kozue, Bando Sachiko, Hayashi Shuji, Takeuchi Hidekazu, 仁木敏之, 楠瀬賢也, 山口浩司, Tomita Noriko, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Cardiac Rehabilitation decreases Urinary Albumin Excretion in Patients with Cardiovascular Disease.,
第76回日本循環器学会学術集会, 2012年3月. Takashima Akira, Takayuki Ise, Takashi Iwase, Yuka Ueda, Masashi Akaike, Yamazaki Hiromu, Mika Bando, Ogasawara Kozue, Bando Sachiko, Tomita Noriko, Takeuchi Hidekazu, Toshiyuki Niki, Hotchi Junko, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata :
Effect of Cardiac Rehabilitation on Level of Oxidized LDL.,
第76回日本循環器学会学術集会, Mar. 2012. 添木武, 仁木敏之, 山口浩司, 坂東左知子, 上田由佳, 冨田紀子, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2012年3月. 立花綾香, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 廣野明 :
CRT-Dが著効した重症慢性心不全の1例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 田岡志保, 上田由佳, 伊勢孝之, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 仁木敏之, 發知淳子, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 井上洋行 :
テニスラケットによる外傷が誘因で深部静脈血栓・急性肺塞栓症を来した一症例,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 坂東美佳, 山田博胤, 冨田紀子, 發知淳子, 小笠原梢, 高島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 上田由佳, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智 :
脂質低下療法による頸動脈プラーク安定化の評価:超音波integrated backscatterを用いたカラーマッピングシステムの臨床応用,
第244回徳島医学会学術集会 (平成23年度冬期), 2012年2月. 太田理絵, 若槻哲三, 岩瀬俊, 髙尾正一郎, 山田博胤, 赤池雅史, 坂東左知子, 仁木敏之, 能勢隼人, 冨田紀子, 山口浩司, 竹谷善雄, 添木武, 西岡安彦, 原田雅史, 佐田政隆 :
肺，皮膚病変診断4年後に心病変が顕在化したサルコイドーシスの1例,
第22回日本心血管画像動態学会, 2012年1月. 前田香代子, 上田由佳, 伊勢孝之, 岩瀬俊, 西川幸治, 高島啓, 小笠原梢, 山崎宙, 坂東左知子, 仁木敏之, 發知淳子, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げの問題点,
第99回日本循環器学会四国地方会, 2011年12月. 鶴尾美穂, 寺沢敏秀, 木戸里佳, 湯浅智之, 吉田守美子, 笠松哲司, 黒田暁生, 松久宗英, 松本俊夫, 赤池雅史 :
粥状動脈硬化病変を呈した糖尿病合併高Lp(a)血症の姉妹例,
日本糖尿病学会中国四国地方会第49回総会, 2011年11月. 岩田貴, 島田光生, 栗田信浩, 佐藤宏彦, 西岡将規, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 髙須千絵, 赤池雅史 :
スキルスラボのシミュレーターを駆使した医療トレーニングの有用性 (第49回日本癌治療学会学術集会),
日本癌治療学会誌, Vol.46, No.2, 727, 2011年10月.

(キーワード): 質問紙法 / 外科手術 / 腫瘍 / 医学生涯教育 / ヒト (Homo sapiens)

岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 伊勢孝之, 小笠原梢, 山崎宙, 髙島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
心臓MRIによるサルコイドーシス心病変検出の有用性,
第31回日本サルコイドーシス/肉芽腫性疾患学会総会, 2011年10月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
エイコサペントエン酸の酸化ストレス抑制を介したアンジオテンシンII刺激による心血管リモデリング抑制効果の検討,
第34回日本高血圧学会総会, 2011年10月. 木谷光宏, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 赤池雅史, 山本浩史, 折野俊介, 角谷昭佳, 坂東重信, 佐田政隆 :
高血圧患者におけるシルニジピンの酸化ストレスに対する作用,
第34回日本高血圧学会総会, 2011年10月. Takayuki Ise, Takashi Iwase, Kumiko Kagawa, Toshiyuki Niki, Kenya Kusunose, 冨田紀子, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masahiro Abe, Masashi Akaike and Masataka Sata :
Successful Autologous Peripheral Blood Stem Cell Transplantation for Primary Cardiac Amyloidosis Patients with Heart Failure : three cases report.,
第15回日本心不全学会学術集会, Oct. 2011. 岩瀬俊, 髙尾正一郎, 赤池雅史, 能勢隼人, 久岡白陽花, 伊勢孝之, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 西岡安彦, 原田雅史, 佐田政隆 :
サルコイドーシス心病変検出における心臓MRI検査の有用性,
第59回日本心臓病学会学術集会, 2011年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 冨田紀子, 楠瀬賢也, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンによる自律神経およびConnexin43発現調節を介した抗不整脈作用の検討,
第59回日本心臓病学会学術集会, 2011年9月. 添木武, 坂東左知子, 仁木敏之, 久岡白陽花, 竹内秀和, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動における局所炎症反応に関する検討,
第59回日本心臓病学会学術集会, 2011年9月. 粟飯原賢一, 吉田守美子, 上田由佳, 池田康将, 岩瀬俊, 久岡白陽花, 平田陽一郎, 赤池雅史, 佐田政隆, 松本俊夫 :
Eicosapentaenoic acid-to-arachidonic acid ratio is inversely associated with albuminuria in individuals with cardiovascular risk factors,
第75回日本循環器学会総会・学術集会パシフィコ横浜, 2011年8月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
Eicosapentaenoic acid protects against angiotensin II-induced cardiovascular remodeling via attenuation of oxidative stress.,
第75回日本循環器学会総会・学術集会パシフィコ横浜, 2011年8月. C. Nishio, M. Higashida, Y. Hirata, Hirotsugu Kurobe, Masashi Akaike, Yutaka Nakaya, Tetsuya Kitagawa and Masataka Sata :
GLP-1 Receptor Agonist Attenuates Vascular Remodeling after Endovascular Injury.,
第75回日本循環器学会総会・学術集会, Aug. 2011. M. Higashida, C. Nishio, Y. Hirata, Hirotsugu Kurobe, Masashi Akaike, Yutaka Nakaya, Tetsuya Kitagawa and Masataka Sata :
HMGB1 Plays a Critical Role in Chronic Inflammation and Vascular Remodeling after Endovascular Injury.,
第75回日本循環器学会総会・学術集会, Aug. 2011. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守美子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果 ∼探索的臨床試験による検討∼,
第243回徳島医学会学術集会公開シンポジウム, 2011年7月. 赤池雅史, 土屋浩一郎, 柏田良樹, 高石喜久, 玉置俊晃, 岩瀬俊, 佐田政隆, 粟飯原賢一, 吉田守実子, 松本俊夫, 佐藤千穂, 西条伴香, 楊河宏章 :
生活習慣病関連リスクファクターに及ぼすスダチ果皮加工品の効果-探索的臨床試験による検討-,
第243回徳島医学会学術集会, 2011年7月. 高木恵理, 高島啓, 山口浩司, 竹谷善雄, 坂東左知子, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 森本篤志, 橋本一郎, 中西秀樹, 和田美智子, 石本武男, 田蒔正治 :
重症下肢虚血病変に対して経皮的下肢動脈血管形成術が奏功し，予定されていた下肢切手術を回避できた一症例,
第243回徳島医学会学術集会, 2011年7月. 高島啓, 添木武, 山口浩司, 竹谷善雄, 坂東左知子, 林修司, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 上田由佳, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
埋め込み型デバイスにより胸郭内インピーダンスの増悪と改善が観察できた拡張相肥大型心筋症の一例,
第243回徳島医学会学術集会, 2011年7月. 長宗雅美, 岩田貴, 赤池雅史 :
医療安全をめざした多職種間連携教育の取り組みー徳島大学のIPEモデルー,
第43回日本医学教育学会大会, 2011年7月. 岩田貴, 赤池雅史, 長宗雅美, 島田光生, 栗田信浩, 西岡将規, 沖津宏 :
地域で研修する若手医師に対する大腸癌鏡下手術の教育における問題点と対策:地方からの提言,
第43回日本医学教育学会大会, 2011年7月. 三笠洋明, 赤池雅史, 福井義浩 :
看護学専攻学生に対する統計学教育改善の試み,
2011年7月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
当院心臓リハビリテーション参加者の運動能力について,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
大学病院での心臓リハビリテーション立ち上げに携わって,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排泄量に及ぼす心臓リハビリテーションの効果,
第17回日本心臓リハビリテーション学会学術集会, 2011年7月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
TE-e'は左室拡張末期圧を反映する―下肢腸圧および硝酸薬負荷を用いた検討―,
第84回日本超音波医学会学術集会, 2011年5月. 西尾進, 山田博胤, 楠瀬賢也, 玉井利奈, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
冠動脈硬化症を最も反映する非侵襲的血管検査指標は何か?,
第84回日本超音波医学会学術集会, 2011年5月. 前田香代子, 上田由佳, 久岡白陽花, 岩瀬俊, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
通院型心臓リハビリテーションの継続における開始3カ月目の重要性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 西川幸治, 上田由佳, 久岡白陽花, 前田香代子, 岩瀬俊, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
心臓リハビリによる運動能力改善を阻害する因子の検討,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 太田理絵, 岩瀬俊, 久岡白陽花, 山田博胤, 西岡安彦, 髙尾正一郎, 坂東左知子, 能勢隼人, 楠瀬賢也, 仁木敏之, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
心室固有調律が心病変診断のきっかけとなったサルコイドーシスの1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 原知也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 玉井利奈, 坂東左知子, 久岡白陽花, 仁木敏之, 上田由佳, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスにおける左室形態異常の多様性,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 本田壮一, 川井尚臣, 白川光雄, 小原聡彦, 赤池雅史, 佐田政隆 :
急性冠症候群の医療連携―「海部プロジェクト」自験症例より―,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 久岡白陽花, 上田由佳, 岩瀬俊, 前田香代子, 西川幸治, 坂東左知子, 林修司, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 髙田信二郎, 安井夏生, 佐田政隆 :
尿中アルブミン排出量に及ぼす通院心臓リハビリテーションの効果,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 坂東左知子, 添木武, 久岡白陽花, 冨田紀子, 竹内秀和, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
房室結節三重伝道路の存在が示唆された房室結節リエントリー性頻拍の1例,
第98回日本循環器学会中国・四国合同地方会, 2011年5月. 外磯千智, 岩瀬俊, 楠瀬賢也, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史 :
心臓MRI検査で左室に広範なガドリニウム異常集積を認めたNoonan syndromeの1例,
第104回日本内科学会四国地方会, 2011年5月. 安積麻衣, 岩瀬俊, 仁木敏之, 若槻哲三, 佐田政隆, 赤池雅史, 髙尾正一郎, 原田雅史, 西岡安彦, 曽根三郎 :
眼，肺，筋病変に続いて経過中に新病変の顕在化を認めたサルコイドーシスの一例,
第104回日本内科学会四国地方会, 2011年5月. 粟飯原賢一, 吉田守美子, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
フェノフィブラートはアンジオテンシンⅡ負荷による高血圧と心筋リモデリングを抑制する,
第84回日本内分泌学会学術総会, 2011年4月. 黒部裕嗣, 平田陽一郎, 西雄千佳, 東田真由子, 松岡祐貴, 赤池雅史, 中屋豊, 北川哲也, 佐田政隆 :
GLP-1 receptor agonist が血管リモデリングに与える影響の検討,
第84回日本内分泌学会学術総会, 2011年4月. 池田康将, 粟飯原賢一, 吉田守美子, 佐藤隆史, 赤池雅史, 玉置俊晃, 加藤茂明, 松本俊夫 :
心血管リモデリングにおける男性ホルモンの作用,
第84回日本内分泌学会学術集会シンポジウム「心血管病を内分泌・代謝面から考察する」, 2011年4月. 赤池雅史, 粟飯原賢一, 池田康将, 八木秀介, 石川カズ江, 吉田守美子, 上田由佳, 岩瀬俊, 佐田政隆, 松本俊夫 :
グルココルチコイド誘発性血管内皮細胞障害に対するアルドステロン受容体拮抗薬の効果,
第84回日本内分泌学会学術総会, 2011年4月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
エイコサペントエン酸は酸化ストレス抑制を介してアンジオテンシンⅡ刺激による心血管リモデリングを抑制する,
第84回日本内分泌学会学術総会, 2011年4月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
虚血ストレスによる骨格筋アポトーシスおよび血管新生におけるアンドロゲン受容体の意義,
第84回日本内分泌学会学術総会, 2011年4月. 黒部裕嗣, 粟飯原賢一, 平田陽一郎, 西矢昌子, 中山泰介, 元木達夫, 菅野幹雄, 神原保, 北市隆, 赤池雅史, 佐田政隆, 北川哲也, 松本俊夫 :
エゼチミブ投与による脂質代謝および血管機能改善効果の検討,
第84回日本内分泌学会学術総会, 2011年4月. Yasumasa Ikeda, Ken-ichi Aihara, Masashi Akaike, Sumiko Yoshida, Takashi Iwase, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Masataka Sata, Toshio Matsumoto and Toshiaki Tamaki :
Heparin cofactor II enhances vascular endothelial cells function and angiogenesis,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Bando, Takeshi Soeki, Toshiyuki Niki, Y. Hirata, N. Tomita, H. Takeuchi, Kenya Kusunose, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Plasma Brain Natriuretic Peptide (BNP) Level is Elevated in Patients with Cancer.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 添木武, 仁木敏之, 山口浩司, S. Bando, 上田由佳, N. Tomita, 伊勢孝之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 島袋充生, 佐田政隆 :
Inflammatory Biomarkers as Predictors of Vulnerable Coronary Plaques.,
第76回日本循環器学会学術集会，Symposium 3, 2011年3月. C. Nishio, M. Higashida, Y. Hirata, Hirotsugu Kurobe, Masashi Akaike, Yutaka Nakaya, Tetsuya Kitagawa and Masataka Sata :
GLP-1 Receptor Agonist Attenuates Vascular Remodeling after Endovascular Injury.,
第75回日本循環器学会総会・学術集会, Mar. 2011. M. Higashida, C. Nishio, Y. Hirata, Hirotsugu Kurobe, Masashi Akaike, Yutaka Nakaya, Tetsuya Kitagawa and Masataka Sata :
HMGB1 Plays a Critical Role in Chronic Inflammation and Vascular Remodeling after Endovascular Injury.,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Nishio, Hirotsugu Yamada, Kenya Kusunose, N. Tomita, S. Hayashi, K. Endo, R. Tamai, J. Miki, S. Bando, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Which Noninvasive Vascular Index is the Best Predictor of the Severity of Coronary Atherosclerosis?,
第75回日本循環器学会総会・学術集会, Mar. 2011. S. Hayashi, Hirotsugu Yamada, S. Nishio, N. Tomita, Kenya Kusunose, K. Endo, R. Tamai, S. Bando, S. Hisaoka, H. Takeuchi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Tricuspid Annular Motion Velocity in Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Toshiyuki Niki, Takeshi Soeki, S. Bando, Kenya Kusunose, S. Hisaoka, S. Hayashi, Yuka Ueda, S. Tomita, H. Takeuchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Role of Circulating High-Mobility Group Box-1 (HMGB1) in Patients with Coronary Artery Disease.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Kenya Kusunose, Hirotsugu Yamada, N. Tomita, S. Nishio, S. Bando, S. Hisaoka, S. Hayashi, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
Clinical Efficacy of Beat-to-beat Variability of Diastolic Filling in Atrial Fibrillation.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Koji Yamaguchi, Tetsuzo Wakatsuki, Toshiyuki Niki, Koji Yamaguchi, S. Bando, S. Hisaoka, S. Hayashi, Yuka Ueda, N. Tomita, H. Takeuchi, Kenya Kusunose, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Local Persistent Coagulative Response to Zotarolimus-eluting, Sirolimus-eluting and Bare-metal Stents Implanted in Patients with Stable Angina.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Takashi Iwase, Shoichiro Takao, Masashi Akaike, S. Bando, S. Hisaoka, Toshiyuki Niki, Kenya Kusunose, N Tomita, Y. Hirata, Yuka Ueda, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, M. Harada and Masataka Sata :
Diagnostic Utility of Cardiac Magnetic Resonance for Prediction of Cardiac Events in Patients with Hypertrophic Cardiomyopathy.,
第75回日本循環器学会総会・学術集会, Mar. 2011. Tetsuzo Wakatsuki, Koji Yamaguchi, Yoshio Taketani, Toshiyuki Niki, Kenya Kusunose, N. Tomita, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Analysis of Tissue Characteristics of In-Stent Restenotic Lesion 5-Years after Coronary Stenting with Drug-Eluting Stent Using Integrated Backscatter Intravascular Ultrasound.,
第75回日本循環器学会総会・学術集会, Mar. 2011. 高柳友貴, 仁木敏之, 坂東左知子, 久岡白陽花, 林修司, 上田由佳, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 岩瀬俊, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 中山泰介, 北川哲也, 村野栄一 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 原田雅史 :
拡張型心筋症として診断・加療されていた心サルコイドーシスの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 能勢隼人, 大塚秀樹, 髙尾正一郎, 原田雅史 :
心サルコイドーシスにおける左室形態異常の多様性,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 太田理絵, 冨田紀子, 楠瀬賢也, 坂東左知子, 久岡白陽花, 林修司, 竹内秀和, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 木村建彦, 西内健, 黒部裕嗣, 北川哲也 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 岩田貴, 長宗雅美, 辻暁子, 福富美紀, 射場智美, 赤池雅史 :
医療安全の学習基盤形成を目指した早期職種間連携教育の取り組み.,
第242回徳島医学会学術集会, 2011年2月. 髙島啓, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 坂東左知子, 久岡白陽花, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 竹崎彰夫, 多田浩也, 曽根三郎 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性高血圧症の検出,
第242回徳島医学会学術集会，平成22年度冬期, 2011年2月. 竹内秀和, 久岡白陽花, Toshiyuki Niki, Koji Yamaguchi, Takashi Iwase, Takeshi Soeki, Masashi Akaike and Masataka Sata :
Fibrinogen relates to free triiodothyronin (FT3) negatively, which might be regulated via Hdac3.,
第97回日本循環器学会四国地方会, Feb. 2011. 平田陽一郎, 元木達夫, 黒部裕嗣, 赤池雅史, 田端実, 高梨秀一郎, 北川哲也, 佐田政隆 :
心臓周囲脂肪組織における炎症性サイトカインの発見と冠動脈病変の関連,
第40回日本心脈管作動物質学会, 2011年2月. 山田博胤, 玉井利奈, 清水拓, 西尾進, 岩瀬俊, 楠瀬賢也, 遠藤桂輔, 赤池雅史, 佐田政隆, 八木秀介 :
膠原病と肺高血圧,
肺高血圧症とエンドセリン学術講演会, 2010年12月. 小笠原梢, 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 竹崎彰夫, 多田浩也, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndromeの1例,
第97回日本循環器学会四国地方会, 2010年12月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 平田陽一郎, 冨田紀子, 竹内秀和, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 岩瀬俊, 赤池雅史, 佐田政隆 :
二種類の上室性頻拍出が認められた例,
第97回日本循環器学会四国地方会, 2010年12月. 高柳友貴, 仁木敏之, 山田博胤, 楠瀬賢也, 山口浩司, 岩瀬俊, 冨田紀子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ペースメーカーリードの弁尖穿通による重症三尖弁逆流症の1例,
第97回日本循環器学会四国地方会, 2010年12月. 竹内秀和, 平田陽一郎, 冨田紀子, Kenya Kusunose, Yoshio Taketani, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata :
HDL-C interacts to EPA positively,which might mean HDL-C regulates EPA via SREBP.,
第97回日本循環器学会四国地方会, Dec. 2010. 坂東美佳, 仁木敏之, 楠瀬賢也, 山口浩司, 竹内秀和, 竹谷義雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心サルコイドーシスの1例,
第97回日本循環器学会四国地方会, 2010年12月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
アンドロゲン受容体は虚血後骨格筋細胞のアポトーシスと血管新生を制御する,
第18回日本血管生物医学会学術集会, 2010年12月. 平田陽一郎, Tatsuo Motoki, Hirotsugu Kurobe, Masashi Akaike, 田端実, 高梨秀一郎 and Masataka Sata :
Macrophages shift toward inflammatory state in epicardial fat of patients with coronary artery disease.,
第18回日本血管生物医学会学術集会, Dec. 2010. 平田陽一郎, Tatsuo Motoki, Hirotsugu Kurobe, Masashi Akaike, 田端実, 高梨秀一郎 and 佐田政隆 :
Macrophages shift toward inflammatory state in epicardial fat of patients with coronary artery disease.,
Dec. 2010. 赤池雅史 :
虚血性心疾患と喫煙 ∼職場における喫煙対策を含めて∼,
第5回日本禁煙科学会学術総会, 2010年11月. 末広英也, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第103回日本内科学会四国地方会, 2010年11月. 山崎宙, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
趾間部のマダニ咬傷後に足趾血行不良から壊死に陥った1例,
第103回日本内科学会四国地方会, 2010年11月. 赤池雅史 :
後期専門研修医の教育のあり方,
日本臨床麻酔学会第30回大会, 2010年11月. 遠藤桂輔, 斉藤憲, 山田博胤, 楠瀬賢也, 冨田紀子, 西尾進, 林修司, 添木武, 赤池雅史, 佐田政隆 :
高度僧帽弁輪石灰化による多発性脳梗塞の1例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 太田理恵, 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
産後の甲状腺機能亢進が診断の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 河野裕美, 山田博胤, 佐藤光代, 西尾進, 冨田紀子, 遠藤桂輔, 楠瀬賢也, 添木武, 赤池雅史, 佐田政隆 :
Intramural hematoma(IMH)を呈したStanford B型大動脈解離の二例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 玉井利奈, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 楠瀬賢也, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
三次元心エコー法により術前診断ができたペースメーカーリードの弁尖穿通による重症三尖弁逆流の一例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 林修司, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 遠藤桂輔, 玉井利奈, 添木武, 赤池雅史, 佐田政隆 :
徐脈の高齢者において僧帽弁口血流波形がE>Aを呈するメカニズムについての検討,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 清水拓, 山田博胤, 楠瀬賢也, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性肺高血圧症の検出,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 末広英也, 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 冨田紀子, 玉井利奈, 遠藤桂輔, 赤池雅史, 佐田政隆 :
心室中隔肥厚を認めた心サルコイドーシスの1例,
第20回日本超音波医学会四国地方会学術集会, 2010年10月. 赤池雅史, 八木秀介, 粟飯原賢一, 石川カズ江, 池田康将, 吉田守美子, 上田由佳, 岩瀬俊, 松本俊夫, 佐田政隆 :
ピタバスタチンによる血管内皮細胞での一酸化窒素合成酵素の発現亢進作用とその機序の検討,
第33回日本高血圧学会総会, 390, 2010年10月.

(キーワード): *血管内皮 *高血圧(薬物療法) *Pitavastatin(治療的利用,薬理学) *内皮細胞 *Nitric Oxide Synthase Type III ヒト

山田博胤, 三代裕一郎, 楠瀬賢也, 仁木敏之, 林修司, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高齢者および壮年者における高圧利尿薬インダパミドの少量追加投与の有効性と安全性-連日投与と隔日投与の比較-,
第33回日本高血圧学会総会, 2010年10月. 山口浩司, 若槻哲三, 坂東左知子, 久岡白陽花, 仁木敏之, 楠瀬賢也, 冨田紀子, 竹内秀和, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆, 麻植塚浩康 :
冠動脈プラークに対する薬剤多面的効果の検討-Integrated backscatter IVUS観察による観点から-,
第58回日本心臓病学会学術集会, 2010年9月. 若槻哲三, 仁木敏之, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステントによる冠動脈内皮機能障害の経年変化に関する検討,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 山田博胤, 楠瀬賢也, 西尾進, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
S字状中隔を呈する例の心エコー・ドプラ所見についての検討,
第58回日本心臓病学会学術集会, 2010年9月. 坂東左知子, 添木武, 仁木敏之, 久岡白陽花, 竹内秀和, 平田陽一郎, 冨田紀子, 楠瀬賢也, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
脳性ナトリウム利尿ペプチド(BNP)と癌との関係について,
第58回日本心臓病学会学術集会, 2010年9月. 添木武, 仁木敏之, 坂東左知子, 久岡白陽花, 竹内秀和, 楠瀬賢也, 冨田紀子, 平田陽一郎, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 寒川賢治, 佐田政隆 :
グレリンの心臓自律神経への作用と心血管系における意義,
第58回日本心臓病学会学術集会, 2010年9月. 林修司, 山田博胤, 中田拓史, 楠瀬賢也, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形用いた左室拡張能評価の限界:E>Aパターンを呈する高齢者での検討,
第58回日本心臓病学会学術集会, 2010年9月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
EPA/AA比は冠動脈疾患の重症度に相関する:徳島大学病院循環器内科データベースを用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み慢性期における冠動脈局所凝固異常に対するスタチンの効果,
第58回日本心臓病学会学術集会, 2010年9月. 冨田紀子, 楠瀬賢也, 玉井利奈, 遠藤桂輔, 西尾進, 三木淳子, 林修司, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
出産後の甲状腺機能亢進症が発見の契機となったLeft Main Coronary Trunk Compression Syndromeの一例,
第58回日本心臓病学会学術集会, 2010年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 玉井利奈, 遠藤桂輔, 三木淳子, 坂東左知子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
拡張型心筋症の左室内同期不全に対する前負荷増大の影響:3次元心エコー法を用いた検討,
第58回日本心臓病学会学術集会, 2010年9月. 玉井利奈, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
下肢陽圧負荷心エコー法が臨床的に有用であった肥大型心筋症の2例,
第58回日本心臓病学会学術集会, 2010年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 玉井利奈, 遠藤桂輔, 三木淳子, 竹崎彰夫, 多田浩也, 添木武, 若槻哲三, 赤池雅史, 曽根三郎, 佐田政隆 :
コントラスト心エコー法で診断できたHepatopulmonary Syndoromeの1例,
第58回日本心臓病学会学術集会, 2010年9月. Hirata Yoichiro, Tatsuo Motoki, Hirotsugu Kurobe, Masashi Akaike, Tabata Minoru, Takanashi Shuichiro, Igarashi Takashi, Tetsuya Kitagawa and Masataka Sata :
Macrophage Polarization in Epicardial Adipose Tissue Enhances Atherosclerosis of Human Coronary Arteries.,
The58th Annual Scientific Session of the Japanese College of Cardiology, Sep. 2010. 赤池雅史, 寺嶋吉保, 三笠洋明, 土井俊夫, 福井義浩 :
共用試験医学系OSCE医療面接ステーションに並施した臨床推論筆記試験の試み,
第42回日本医学教育学会, 2010年7月. 赤池雅史, 三笠洋明, 岡田達也, 森川富昭, 寺嶋吉保, 泉啓介, 福井義浩 :
WEB講義日程表による講義データベースの構築とその活用,
第42回日本医学教育学会, 2010年7月. 赤池雅史 :
第42回日本医学教育学会ランチョンセミナー「専門医研修のブースター」 ―高度医療人養成推進事業とシミュレーション教育―人工心肺補助訓練および豚を用いた技能講習会,
第42回日本医学教育学会, 2010年7月. 三笠洋明, 赤池雅史, 寺嶋吉保, 大森哲郎, 福井義浩 :
医学科卒業試験問題の難易度・識別力判定のための項目特性分析,
第42回日本医学教育学会大会, 2010年7月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
A role of androgen receptor in ischemia-induced tissue damage and angiogenesis in male,
第42回日本動脈硬化学会総会・学術集会長良川国際会議場, 2010年7月. Y. Sumiko, Ken-ichi Aihara, T. Ise, Yuka Ueda, Yasumasa Ikeda, Takashi Iwase, Masashi Akaike, Masataka Sata and Toshio Matsumoto :
A role of androgen receptor in iscchemia-induced tissue damage and angiogenesis in male.,
第42回日本動脈硬化学会総会・学術集会, Jul. 2010. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
アンドロゲンーアンドロゲン受容体系は下肢虚血における組織傷害防御と血管新生に必須である,
2010 年度(第 52 回)日本老年医学会学術集会神戸国際会議場・神戸商工会議所・神戸ポートピアホテル, 2010年6月. 小笠原梢, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆, 北川哲也 :
IgA腎症ともやもや病を合併した若年発症の感染性心内膜炎の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 岩河早保, 楠瀬賢也, 岩瀬俊, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 竹谷善雄, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆, 橋詰俊二, 木村建彦, 西内健 :
出産後left main compression syndromeによる狭心症を発症した心内膜床欠損(不完全型)の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 坂東美佳, 山口浩司, 岩瀬俊, 楠瀬賢也, 仁木敏之, 冨田紀子, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高度拡張不全による心不全症状の再燃を認めた心尖部肥大型心筋症の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 阿部容子, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 冨田紀子, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 坂東正章, 清水渉, 佐田政隆 :
KCNH2遺伝子にダブル変異を認めた先天性QT延長症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 楠瀬賢也, 竹谷善雄, 西尾進, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
右腎癌摘出後に心不全を繰り返した腎動脈狭窄症の一例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 仁木敏之, 添木武, 楠瀬賢也, 山口浩司, 小柴邦彦, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
心電図異常が乏しいBrugada症候群の1例,
第96回日本循環器学会中国・四国合同地方会, 2010年6月. 鹿草宏, 仁木敏之, 楠瀬賢也, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
急性大動脈解離の1例,
日本内科学会第102回四国地方会, 2010年5月. 原知也, 仁木敏之, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 関啓 :
大動脈二尖弁における感染性心内膜炎に合併した大動脈弁輪周囲膿瘍の1例,
日本内科学会第102回四国地方会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
虚血の診断に有用な指標は何か?,
日本超音波医学会第83回学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
卵円孔開存の診断におけるコントラストリアルタイム3次元経食道心エコー法の有用性,
日本超音波医学会第83回学術集会, 2010年5月. 高島弘光, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三村千尋, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
大動脈弁硬化における頸動脈の動脈硬化所見の検討,
日本超音波医学会第83回学術集会, 2010年5月. 山田博胤, 楠瀬賢也, 西尾進, 河野裕美, 佐藤光代, 冨田紀子, 林修司, 添木武, 赤池雅史, 佐田政隆 :
下肢陽圧負荷時の僧帽弁口血流速波形の反応性を用いた軽症心不全患者の予後予測:''前負荷ストレス心エコー法''の臨床応用,
日本超音波医学会第83回学術集会, 2010年5月. 竹谷善雄, 若槻哲三, 山田博胤, 山口浩司, 西尾進, 楠瀬賢也, 冨田紀子, 林修司, 仁木敏之, 小柴邦彦, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
スタチンによる冠動脈プラーク性状の短期変化についてのIB-IVUSを用いた検討,
第21回日本心エコー図学会学術集会, 2010年5月. 林修司, 山田博胤, 西尾進, 楠瀬賢也, 冨田紀子, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 仁木敏之, 山口浩司, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
3次元経食道心エコー(3D-TEE)法にて経過が観察できた巨大左心耳血栓の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
リアルタイム3次元経食道エコー法により観察しえた孤立性僧帽弁クレフトの1例,
第21回日本心エコー図学会学術集会, 2010年5月. 楠瀬賢也, 山田博胤, 西尾進, 岩瀬俊, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心アミロイドーシスにおける心筋局所ストレインとMRIガドリニウム遅延造影所見の比較,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
コントラスト心エコー法で診断した肝肺症候群の1例,
第21回日本心エコー図学会学術集会, 2010年5月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 林修司, 三木淳子, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房のみの心病変を認めた多発性筋炎の一例,
第21回日本心エコー図学会学術集会, 2010年5月. 中田拓史, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 林修司, 遠藤桂輔, 河野裕美, 平岡葉月, 佐藤光代, 三木淳子, 竹谷善雄, 添木武, 赤池雅史, 佐田政隆 :
僧帽弁口血流速波形がE>Aパターンを呈する高齢者の内訳,
第21回日本心エコー図学会学術集会, 2010年5月. 粟飯原賢一, 吉田守美子, 倉橋清衛, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 松本俊夫, 岩瀬俊, 赤池雅史, 佐田政隆 :
ロスバスタチンによる心筋リモデリング抑制効果の検討,
第83回日本内分泌学会学術総会, 2010年3月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
Accelerated cellular apoptosis and impaired angiogenesis after hindlimb ischemia in male mice lacking androgen receptor,
第74回日本循環器学会総会・学術集会国立京都国際会館, 2010年3月. 黒部裕嗣, 浦田将久, 福原弥生, 神原保, 粟飯原賢一, 赤池雅史, 高浜洋介, 玉置俊晃, 松本俊夫, 冨田修平, 北川哲也 :
血管リモデリング時の転写因子HIF-1αの役割 (第110回日本外科学会定期学術集会),
日本外科学会雑誌, Vol.111, No.2, 701, 2010年3月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543027394884480

(CiNii: 1572543027394884480) 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 河野裕美, 佐藤光代, 添木武, 赤池雅史, 佐田政隆, 平岡葉月 :
心エコー・ドプラ指標により前負荷軽減に対する心反応性は予測できるか,
日本超音波医学会四国地方会, 2009年12月. 岡田達也, 森川富昭, 玉木悠, 田木真和, 森口博基, 寺嶋吉保, 三笠洋明, 赤池雅史, 矢野米雄 :
PBLにおけるシナリオ作成支援,
医療情報学連合大会論文集29回, 913-914, 2009年11月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 山田博胤, 佐田政隆, 西尾進 :
副腎アンドロゲンDHEASの抗動脈硬化作用における性差の検討,
第32回日本高血圧学会学術集会, 2009年10月. 粟飯原賢一, 藤中雄一, 木内美瑞穂, 吉田守美子, 鈴木麗子, 倉橋清衛, 遠藤逸朗, 八木秀介, 岩瀬俊, 平田陽一郎, 赤池雅史, 佐田政隆, 松本俊夫 :
内臓脂肪蓄積制御に関わる因子の臨床的検討,
第32回日本高血圧学会総会, 196, 2009年10月.

(キーワード): LDL Cholesterol 危険因子 *腹腔内脂肪(X線診断) ヒト中年(45~64) 高齢者(65~79) 男女

吉田守美子, 粟飯原賢一, 伊勢孝之, 上田由佳, 八木秀介, 岩瀬俊, 山田博胤, 赤池雅史, 佐田政隆, 松本俊夫 :
副腎アンドロゲンDHEASの抗動脈硬化作用における性差の検討,
第32回日本高血圧学会総会, 2009年10月. 赤池雅史, 粟飯原賢一, 池田康将, 石川カズ江, 吉田守美子, 上田由佳, 八木秀介, 岩瀬俊, 松本俊夫, 佐田政隆 :
ミネラルコルチコイド受容体を介したグルココルチコイド過剰による血管内皮細胞障害作用,
第32回日本高血圧学会総会, 244, 2009年10月.

(キーワード): *Glucocorticoids *血管内皮細胞系 *Mineralocorticoid Receptors *内皮細胞ヒト

山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
シロリムス溶出性ステント留置後における局所凝固反応とステント長の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 岩瀬俊, 髙尾正一郎, 赤池雅史, 足立克仁, 八木秀介, 仁木敏之, 楠瀬賢也, 山口浩司, 小柴邦彦, 山田博胤, 添木武, 若槻哲三, 原田雅史, 西谷弘, 佐田政隆 :
Duchenne型筋ジストロフィー女性キャリアにおける心病変早期検出の試み-心臓MRIによる検討-,
第57回日本心臓病学会学術集会, 2009年9月. 冨田紀子, 楠瀬賢也, 山田博胤, 西尾進, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
大動脈弁硬化の進行に関連する因子,
第57回日本心臓病学会学術集会, 2009年9月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
Th1/Th2バランスの改善を介したPravastatinの実験的自己免疫性心筋炎抑制効果,
第57回日本心臓病学会学術集会, 2009年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後慢性期の冠動脈局所炎症と凝固異常遷延の関連性,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 佐藤光代, 平岡葉月, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
ASD，PSに合併した右室転移性腫瘤の1例,
第57回日本心臓病学会学術集会, 2009年9月. 添木武, 仁木敏之, 小柴邦彦, 楠瀬賢也, 平田陽一郎, 山口浩司, 八木秀介, 冨田紀子, 竹谷善雄, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
血漿pentraxin3 (PTX3)濃度は冠動脈不安定プラークの指標となり得るか?,
第57回日本心臓病学会学術集会, 2009年9月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の開始時間の差は左室拡張末期圧を反映する:下肢陽圧負荷を用いた検討,
第57回日本心臓病学会学術集会, 2009年9月. 近藤可菜, 八木秀介, 赤池雅史, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 竹谷善雄, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者に対するAdaptive-servo ventilator療法の効果,
第239回徳島医学会学術集会, 2009年8月. 平田陽一郎, 仁木敏之, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 黒部裕嗣, 神原保, 筑後文雄, 北川哲也, 堀貴樹 :
冠動脈周囲脂肪組織におけるマクロファージ浸潤の動脈硬化病変形成に与える影響,
第239回徳島医学会学術集会, 2009年8月. 粟飯原賢一, 藤中雄一, 木内美瑞穂, 吉田守美子, 倉橋清衛, 遠藤逸朗, 上田由佳, 平田陽一郎, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
Influence of lipid profile on endothelial function in subjects with cardiovascular risk factors,
第41回日本動脈硬化学会総会・学術集会, 2009年7月. 吉田守美子, 粟飯原賢一, 上田由佳, 倉橋清衛, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
Regular use of rosuvastatin attenuates carotid atherosclerosis regardless of LDL cholesterol lowering effect,
第41回日本動脈硬化学会総会・学術集会, 2009年7月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 楠瀬賢也, 冨田紀子, 赤池雅史, 北市隆, 北川哲也, 佐田政隆 :
3D経食道心エコー法で診断できた僧帽弁位人工弁機能不全の一例,
第34回日本超音波検査学会, 2009年6月. 仁木敏之, 若槻哲三, 山口浩司, 楠瀬賢也, 小柴邦彦, 八木秀介, 竹谷善雄, 冨田紀子, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの二例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 小柴邦彦, 仁木敏之, 楠瀬賢也, 平田陽一郎, 山口浩司, 冨田紀子, 竹谷善雄, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 添木武, 赤池雅史, 佐田政隆 :
多発性筋炎に伴う心障害の一例,
第94回日本循環器学会中国・四国合同地方会, 2009年6月. 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
安静時post systolic shortening による虚血心筋の検出,
日本超音波医学会第82回学術集会, 2009年5月. 西尾進, 山田博胤, 楠瀬賢也, 平岡葉月, 佐藤光代, 多田津陽子, 冨田紀子, 添木武, 赤池雅史, 佐田政隆 :
下肢静脈血栓スクリーニング検査で発見されたベーカー嚢胞破裂の2症例,
日本超音波医学会第82回学術集会, 2009年5月. 鶴尾美穂, 寺澤敏秀, 三原正明, 湯浅智之, 江尻純子, 笠松哲司, 瀬尾浩二, 木内美瑞穂, 工藤美千代, 吉田守美子, 赤池雅史 :
著名な高Lp(a)血症を合併した糖尿病患者における血管障害の検討,
第52回日本糖尿病学会年次学術集会, 2009年5月. 倉橋清衛, 吉田守美子, 遠藤逸朗, 粟飯原賢一, 藤中雄一, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
一酸化炭素中毒にて急性心筋梗塞を発症した2型糖尿病の1例,
第100回日本内科学会四国地方会, 2009年5月. 八木秀介, 岩瀬俊, 赤池雅史, 山口浩司, 小柴邦彦, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆 :
重症心不全患者における酸素療法とAdaptive-servo ventilator療法の効果の比較検討,
日本内科学会第100回四国地方会, 2009年5月. 遠藤逸朗, 藤村光則, 吉田守美子, 栗若里佳, 木戸慎介, 岩瀬俊, 井上大輔, 粟飯原賢一, 藤中雄一, 赤池雅史, 松本俊夫 :
冠動脈不安定プラーク予測因子としてのICTP,
第82回日本内分泌学会学術総会, Vol.85, No.1, 283, 2009年4月.

(キーワード): 生物学的マーカー *Peptide Fragments(血液) *冠状動脈硬化症(診断) *動脈硬化症-アテローム性(診断) *Collagen Type I(血液) *ICTP (Collagen Type I C-Terminal Telopeptides)(血液) ヒト男女

赤池雅史, 粟飯原賢一, 池田康将, 石川カズ江, 住友由佳, 吉田守美子, 八木秀介, 岩瀬俊, 松本俊夫, 佐田政隆 :
グルココルチコイド誘発性血管内皮細胞障害におけるミネラルコルチコイド受容体の関与,
第82回日本内分泌学会学術総会, Vol.85, No.1, 373, 2009年4月.

(キーワード): *Glucocorticoids(毒性・副作用) *血管内皮培養細胞 *Mineralocorticoid Receptors(薬理学) *内皮細胞ヒト

吉田守美子, 粟飯原賢一, 西尾進, 倉橋清衛, 遠藤逸朗, 藤中雄一, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 山田博胤, 赤池雅史, 佐田政隆, 松本俊夫 :
副腎アンドロゲンDHEASは血管内皮機能非依存的に頸動脈硬化を抑制する,
第82回日本内分泌学会学術総会, Vol.85, No.1, 366, 2009年4月.

(キーワード): *頸動脈疾患 *血管内皮 *動脈硬化症 *Dehydroepiandrosterone Sulfate(薬理学) ヒト男女

佐藤光代, 楠瀬賢也, 山田博胤, 西尾進, 平岡葉月, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
経食道心エコー検査により治療経過が観察できた高安動脈炎に伴う肺動脈狭窄症の一例,
第20回日本心エコー図学会学術集会, 2009年4月. 平岡葉月, 山田博胤, 西尾進, 佐藤光代, 高松直子, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心エコーによる心病変の経過観察が可能であった続発性(AA)アミロイドーシスの一例,
第20回日本心エコー図学会学術集会, 2009年4月. 西尾進, 山田博胤, 楠瀬賢也, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
三尖弁輪運動速波形を用いた二次性肺高血圧の評価,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
Post systolic shortening(PSS)による心筋虚血の検出,
第20回日本心エコー図学会学術集会, 2009年4月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 平岡葉月, 佐藤光代, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
僧帽弁口血流と僧帽弁輪運動の不整合は左室拡張能の評価に有用か:dual Doppler systemを用いた検討,
第20回日本心エコー図学会学術集会, 2009年4月. 吉田守美子, 粟飯原賢一, 倉橋清衛, 遠藤逸朗, 藤中雄一, 住友由佳, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史 :
DHEASは血管内皮機能に依存せず動脈硬化を抑制する(頸動脈エコーを用いた臨床的検討),
第106回日本内科学会総会・講演会, Vol.98, No.Suppl., 139, 2009年4月.

(キーワード): *頸動脈(超音波診断) *超音波診断 *動脈硬化症(超音波診断) *Dehydroepiandrosterone Sulfate(薬理学,血液) ヒト男女

粟飯原賢一, 吉田守美子, 倉橋清衛, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 松本俊夫, 岩瀬俊, 赤池雅史, 佐田政隆 :
ロスバスタチンによる心筋リモデリング抑制効果の検討,
第83回日本内分泌学会学術総会国立京都国際会館, 2009年3月. 粟飯原賢一, 吉田守美子, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 倉橋清衛, 遠藤逸朗, 藤中雄一, 赤池雅史, 佐田政隆, 松本俊夫 :
Increased serum triglyceride but not LDL cholesterol is associated with left ventricular diastolic dysfunction.,
第73回日本循環器学会総会・学術集会, 2009年3月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 倉橋清衛, 遠藤逸朗, 藤中雄一, 赤池雅史, 佐田政隆, 松本俊夫 :
Dehydroepiandrosterone sulfate is an antivascular remodeling factor,
第73回日本循環器学会総会・学術集会, 2009年3月. 住友由佳, 粟飯原賢一, 伊勢孝之, 吉田守美子, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
Heparin Cofactor II-deficient Mice Exert Exacerbation of Angiotensin II-induced Cardiac Remodeling through Enhancement of NADPH oxidase - TGF- 1 Pathway,
第73回日本循環器学会総会・学術集会, 2009年3月. 赤池雅史, 粟飯原賢一, 池田康将, 石川カズ江, 吉田守美子, 住友由佳, 八木秀介, 岩瀬俊, 松本俊夫, 佐田政隆 :
Glucocorticoid Excess Causes Vascular Endothelial Cell Dysfunction through Activation of Mineral Corticoid Receptor,
第73回日本循環器学会総会・学術集会, 2009年3月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 冨田紀子, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 河野智彦, 佐田政隆 :
右心不全を契機に診断された肺動脈狭窄症の一例,
第93回日本循環器学会四国地方会, 2008年12月. 八木秀介, 岩瀬俊, 楠瀬賢也, 仁木敏之, 山口浩司, 小柴邦彦, 冨田紀子, 山田博胤, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
強皮症に伴う難治性末梢循環不全に対するエンドセリン受容体拮抗薬の有用性,
第93回日本循環器学会四国地方会, 2008年12月. 小柴邦彦, 添木武, 仁木敏之, 楠瀬賢也, 山口浩司, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 佐田政隆 :
両側肺血栓症と多発性体循環系塞栓症を合併した1例,
第93回日本循環器学会四国地方会, 2008年12月. 山口浩司, 若槻哲三, 仁木敏之, 楠瀬賢也, 小柴邦彦, 冨田紀子, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
冠動脈ステント3種(CYPHER, TAXUS, DRIVER)の慢性期病理組織所見の比較と局所凝固反応の関連性,
第93回日本循環器学会四国地方会, 2008年12月. 遠藤逸朗, 藤村光則, 吉田守美子, 栗若里佳, 木戸慎介, 岩瀬俊, 井上大輔, 粟飯原賢一, 藤中雄一, 赤池雅史, 松本俊夫 :
冠動脈不安定プラーク予測因子としてのICTP,
第26回日本骨代謝学会学術集会, 194, 2008年10月.

(キーワード): *Peptide Fragments(血液) *冠状動脈硬化症 *Collagen Type I(血液) *ICTP (Collagen Type I C-Terminal Telopeptides)(血液) ヒト男女

粟飯原賢一, 吉田守美子, 伊勢孝之, 住友由佳, 倉橋清衛, 遠藤逸朗, 藤中雄一, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆 :
左室拡張能に対する脂質代謝異常の意義,
第31回日本高血圧学会総会, 2008年10月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆 :
副腎アンドロゲンDHEASは頚動脈血流の制御因子である,
第31回日本高血圧学会学術集会, 2008年10月. 住友由佳, 粟飯原賢一, 伊勢孝之, 吉田守美子, 松本俊夫, 八木秀介, 岩瀬俊, 添木武, 赤池雅史, 佐田政隆 :
ヘパリンコファクターⅡは抗酸化ストレス作用を介してアンジオテンシンIIによる心房および心室のリモデリングを抑制する,
第31回日本高血圧学会総会, 2008年10月. 赤池雅史, 八木秀介, 粟飯原賢一, 石川カズ江, 池田康将, 吉田守美子, 住友由佳, 岩瀬俊, 阿部純一, 松本俊夫, 佐田政隆 :
ピタバスタチンはERK5-KLF2経路の活性化を介して血管内皮細胞での一酸化窒素合成酵素の発現を亢進する,
第31回日本高血圧学会総会, 2008年10月. 吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆 :
副腎アンドロゲンDHEASの血管への作用(頚動脈エコーを用いた臨床的検討),
第13回武田高血圧シンポジウム, 2008年10月. 西尾進, 山田博胤, 楠瀬賢也, 佐藤光代, 高松直子, 添木武, 赤池雅史, 佐田政隆 :
頸動脈狭窄性病変におけるB-Flowの有用性,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 山中森晶, 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 佐田政隆 :
壁運動正常例におけるpost systolic shortening (PSS) についての検討,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 楠瀬賢也, 山田博胤, 西尾進, 佐藤光代, 添木武, 赤池雅史, 阿部美保, 河野和弘, 角谷昭佳, 佐田政隆 :
リアルタイム3次元経食道心エコー図で診断しえた肺動脈狭窄症の一例,
第18回日本超音波医学会四国地方会学術集会, 2008年10月. 西尾進, 山田博胤, 楠瀬賢也, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 永峰康孝, 佐田政隆 :
Automated Function Imaging法による左室局所壁運動異常評価:心エコー初心者による肉眼的評価との比較,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
高血圧性心疾患における左房ポンプ機能の評価:Left Atrial Ejection Forceを用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 若槻哲三, 山口浩司, 仁木敏之, 楠瀬賢也, 小柴邦彦, 八木秀介, 岩瀬俊, 山田博胤, 添木武, 赤池雅史, 佐田政隆 :
薬剤溶出ステント植え込み後の冠動脈内皮機能障害と局所炎症遷延の関連性,
第56回日本心臓病学会学術集会, 2008年9月. 楠瀬賢也, 山田博胤, 西尾進, 仁木敏之, 山口浩司, 八木秀介, 小柴邦彦, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第56回日本心臓病学会学術集会, 2008年9月. 仁木敏之, 添木武, 小柴邦彦, 楠瀬賢也, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 赤池雅史, 福田大和, 篠原尚典, 福田信夫, 田村禎通, 佐田政隆 :
虚血性心疾患におけるHMGBI (high mobility group box 1) の診断的意義,
第56回日本心臓病学会学術集会, 2008年9月. 粟飯原賢一, 吉田守美子, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 遠藤逸朗, 藤中雄一, 赤池雅史, 松本俊夫 :
脂質代謝異常による左室拡張障害の臨床的検討,
第40回日本動脈硬化学会総会, 249, 2008年7月.

(キーワード): 脂質異常症(合併症) / 左心室機能障害(病因) / ヒト (Homo sapiens) / 男性 (male) / 女性 (female)

吉田守美子, 粟飯原賢一, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 遠藤逸朗, 藤中雄一, 赤池雅史, 松本俊夫 :
副腎アンドロゲンの頸動脈硬化抑制作用に関する検討,
第40回日本動脈硬化学会総会, 253, 2008年7月.

(キーワード): Androgens(治療的利用) / 頸動脈疾患(予防) / 頸動脈疾患(予防) / 動脈硬化症(予防) / 副腎 / ヒト (Homo sapiens) / 男性 (male) / 女性 (female)

八木秀介, 粟飯原賢一, 伊勢孝之, 吉田守美子, 住友由佳, 池田康将, 岩瀬俊, 添木武, 赤池雅史, 松本俊夫 :
ピタバスタチンはRac-1を介した酸化ストレス制御によりeNOS非依存的にアンジオテンシンIIによる心房リモデリングを抑制する,
第40回日本動脈硬化学会総会, 203, 2008年7月.

(キーワード): *Angiotensin II 抗酸化剤(治療的利用) 心房 *動脈硬化症(薬物療法) 酸化ストレス rac GTP-Binding Proteins 心室リモデリング *Pitavastatin(治療的利用) マウス動物

吉田守美子, 粟飯原賢一, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 赤池雅史, 松本俊夫 :
頸動脈血行動態における副腎アンドロゲンの臨床的意義,
第81回日本内分泌学会学術総会, Vol.84, No.1, 202, 2008年5月.

(キーワード): *Androgens(血液) *頸動脈 *副腎血行力学ヒト成人(19~44) 男女

粟飯原賢一, 吉田守美子, 伊勢孝之, 住友由佳, 八木秀介, 岩瀬俊, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 赤池雅史, 松本俊夫 :
左室拡張能における脂質代謝異常の影響に関する検討,
第81回日本内分泌学会学術総会, Vol.84, No.1, 222, 2008年5月.

(キーワード): *脂質異常症 *左心室機能ヒト成人(19~44) 男女

三原正朋, 粟飯原賢一, 藤中雄一, 小杉知里, 木内美瑞穂, 赤池雅史, 松本俊夫 :
トロンビンによるインスリン抵抗性制御機構の解析,
第52回日本糖尿病学会年次学術集会, Vol.51, No.Suppl.1, S-126, 2008年5月.

(キーワード): *Thrombin(治療的利用) *インスリン抵抗性(薬物療法) 3T3-L1細胞マウス動物

岡田早未, 山田博胤, 楠瀬賢也, 佐藤光代, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧性心疾患における左室リモデリングと左室拡張能の関連,
第81回日本超音波医学会学術集会, 2008年5月. 佐藤光代, 山田博胤, 楠瀬賢也, 平岡葉月, 西尾進, 河野裕美, 多田津陽子, 添木武, 赤池雅史 :
高血圧患者における心電図の左房負荷は何を表しているか?-心エコー・ドプラ法による再検討-,
第81回日本超音波医学会学術集会, 2008年5月. 楠瀬賢也, 山田博胤, 河野裕美, 西尾進, 平岡葉月, 佐藤光代, 多田津陽子, 添木武, 赤池雅史 :
心房細動症例におけるTEI indexの有用性:Dual Doppler法を用いた検討,
第81回日本超音波医学会学術集会, 2008年5月. 粟飯原賢一, 伊勢孝之, 吉田守美子, 住友由佳, 八木秀介, 岩瀬俊, 赤池雅史, 松本俊夫 :
1α 25 dihydroxyvitamin D3 is a protective factor against vascular remodeling and glucose tolerance in elderly individuals,
第72回日本循環器学会学術集会, 2008年3月. 住友由佳, 粟飯原賢一, 伊勢孝之, 吉田守美子, 八木秀介, 岩瀬俊, 石川カズ江, 赤池雅史, 松本俊夫 :
Angiotensin II-induced cardiac remodeling is exacerbated with increased oxidative stress in heparin cofactor II-deficient mice.,
第72回日本循環器学会総会・学術集会, 2008年3月. 赤池雅史, 八木秀介, 粟飯原賢一, 池田康将, 石川カズ江, 伊勢孝之, 吉田守美子, 住友由佳, 岩瀬俊, Abe Jun-ichi, 松本俊夫 :
HMG-CoA Reductase Inhibitor Pitavastatin Increases the Expression of Endothelial NOS through Activation of ERK5-KLF2 Pathway in Vascular Endothelial Cells,
第72回日本循環器学会学術集会, 2008年3月. 楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 阿部美保, 北川哲也 :
両心房腫瘤の一例,
第102回UCG談話会, 2008年2月. 楠瀬賢也, 添木武, 仁木敏之, 山口浩司, 小柴邦彦, 山田博胤, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史 :
心エコーで心室中隔瘤の診断に苦慮した心サルコイドーシスの一例,
第91回日本循環器学会四国地方会学術集会, 2007年11月. 住友由佳, 粟飯原賢一, 伊勢孝之, 八木秀介, 岩瀬俊, 赤池雅史, 松本俊夫 :
レニン・アンジオテンシン活性下におけるヘパリンコファクターIIの心筋リモデリングへの影響,
第30回日本高血圧学会総会, 170, 2007年10月.

(キーワード): Angiotensins *Heparin Cofactor II Renin *心室リモデリングマウス動物

八木秀介, 粟飯原賢一, 池田康将, 伊勢孝之, 住友由佳, 岩瀬俊, 赤池雅史, 松本俊夫 :
Pitavastatinはangiotensin IIによる心腎障害をeNOS非依存性にrac1抑制による酸化ストレス抑制を介して改善する,
第30回日本高血圧学会総会, 205, 2007年10月.

(キーワード): Angiotensin II *心臓疾患(実験的) *腎臓疾患(実験的) *酸化ストレスノックアウトマウス rac GTP-Binding Proteins *Pitavastatin(薬理学) マウス動物

赤池雅史, 粟飯原賢一, 八木秀介, 池田康将, 石川カズ江, 住友由佳, 岩瀬俊, 松本俊夫 :
グルココルチコイド誘発性高血圧に対するピタバスタチンの効果とその機序の検討,
第30回日本高血圧学会総会プログラム, 210, 2007年10月.

(キーワード): Glucocorticoids *高血圧(薬物療法,実験的) C57BLマウス *Pitavastatin(治療的利用,薬理学) マウス動物オス

粟飯原賢一, 池田康将, 八木秀介, 伊勢孝之, 住友由佳, 岩瀬俊, 赤池雅史, 松本俊夫 :
血管リモデリング制御因子としての活性化ビタミンD,
第30回日本高血圧学会総会, 260, 2007年10月.

(キーワード): *Vitamin D(治療的利用) *動脈硬化症(薬物療法,診断) *血管リモデリングヒト男女

粟飯原賢一, 吉田守美子, 近藤剛史, 栗若里佳, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 八木秀介, 住友由佳, 赤池雅史, 松本俊夫 :
活性型ビタミンDは血漿アンチトロンビン活性の制御に関与する,
日本内分泌学会第7回四国支部学術集会, Vol.83, No.4, 834, 2007年9月.

(キーワード): *Antithrombins(血液) *Calcitriol(治療的利用,薬理学) ヒト中年(45~64) 高齢者(65~79) 男女

楠瀬賢也, 山田博胤, 仁木敏之, 山口浩司, 小柴邦彦, 河野智仁, 添木武, 若槻哲三, 八木秀介, 岩瀬俊, 赤池雅史, 谷口哲三, 髙尾正一郎 :
不可解な心電図異常を呈し，肥大型心筋症を疑う1例,
第12回中国四国心筋症研究会, 2007年9月. 粟飯原賢一, 池田康将, 八木秀介, 住友由佳, 岩瀬俊, 赤池雅史, 松本俊夫 :
活性化ビタミンDは臨床的動脈硬化抑制因子である,
第39回日本動脈硬化学会総会・学術集会, 250, 2007年7月.

(キーワード): *Calcitriol(血液) 断面研究 *動脈硬化症(予防) ヒト中年(45~64) 高齢者(65~79) 男女

粟飯原賢一, 池田康将, 八木秀介, 住友由佳, 岩瀬俊, 近藤剛史, 重清友理, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 赤池雅史, 松本俊夫 :
活性化ビタミンDの抗動脈硬化作用に関する臨床的検討,
第80回日本内分泌学会学術総会, Vol.83, No.1, 159, 2007年6月.

(キーワード): *Calcitriol(治療的利用,薬理学) *動脈硬化症(薬物療法,診断) Maxacalcitol(血液) ヒト中年(45~64) 高齢者(65~79) 男女

岩瀬俊, 住友由佳, 八木秀介, 池田康将, 粟飯原賢一, 尾崎修治, 赤池雅史, 安倍正博, 松本俊夫, 北川哲也 :
エリスロポイエチンを用いた新たな血管新生療法の試み,
第104回日本内科学会総会・講演会, Vol.96, No.Suppl., 133, 2007年4月.

(キーワード): *Erythropoietin(治療的利用) 血液成分除去法 *動脈閉塞性疾患(治療) *末梢血幹細胞移植ヒト

粟飯原賢一, 赤池雅史, 池田康将, 八木秀介, 住友由佳, 岩瀬俊, 東博之, 松本俊夫 :
活性化ビタミンDによる血管リモデリング制御作用,
第104回日本内科学会総会・講演会, Vol.96, No.Suppl., 194, 2007年4月.

(キーワード): *Vitamin D(治療的利用) *動脈閉塞性疾患(診断,薬物療法) *末梢血管疾患(診断,薬物療法) *血管リモデリングヒト中年(45~64) 高齢者(65~79) 男女

八木秀介, 粟飯原賢一, 池田康将, 住友由佳, 岩瀬俊, 赤池雅史, 松本俊夫 :
PitavastatinはAngiotensin IIによる心血管リモデリングと腎障害をeNOS非依存性に抑制する,
第36回日本心脈管作動物質学会, Vol.30, No.1, 24, 2007年2月.

(キーワード): Angiotensin II(毒性・副作用) *腎臓疾患(実験的,化学的誘発) 経口投与酸化ストレス *心室リモデリング *Pitavastatin(薬理学) *血管リモデリング *Nitric Oxide Synthase Type III マウス動物

池田康将, 粟飯原賢一, 赤池雅史, 住友由佳, 八木秀介, 岩瀬俊, 東博之, 加藤茂明, 松本俊夫 :
アンドロゲン-アンドロゲン受容体システムによる血管リモデリング制御機構の解析,
第36回日本心脈管作動物質学会, Vol.30, No.1, 35, 2007年2月.

(キーワード): *Androgens Angiotensin II *Androgen Receptors 酸化ストレス一酸化窒素 *血管リモデリングマウス動物オス

赤池雅史, 粟飯原賢一, 池田康将, 石川カズ江, 八木秀介, 住友由佳, 岩瀬俊, 松本俊夫 :
ピタバスタチンは血管内皮機能の改善を介してグルココルチコイド過剰による高血圧を予防する,
第36回日本心脈管作動物質学会, Vol.30, No.1, 39, 2007年2月.

(キーワード): *Dexamethasone(毒性・副作用) Glucocorticoids(毒性・副作用) *血管内皮 *高血圧(予防,化学的誘発,実験的) *Pitavastatin(治療的利用,薬理学) マウス動物オス

粟飯原賢一, 池田康将, 八木秀介, 住友由佳, 岩瀬俊, 東博之, 加藤茂明, 赤池雅史, 松本俊夫 :
ApoE欠損マウスにおける血漿ヘパリンコファクターII活性の低下は酸化ストレスを増大させ粥状動脈硬化を促進させる,
第36回日本心脈管作動物質学会, Vol.30, No.1, 41, 2007年2月.

(キーワード): *Apolipoproteins E *Heparin Cofactor II *動脈硬化症-アテローム性(実験的) 免疫組織化学 *酸化ストレスノックアウトマウスマウス動物

多田真理枝, 住友由佳, 岩瀬俊, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫, 山田博胤 :
心不全症状を繰り返した心尖部肥大型心筋症の一例,
第89回日本循環器学会四国地方会, 2006年12月. Hirotsugu Kurobe, Yuki Izawa, Yayoi Fukumura, Tamotsu Kanbara, Atsushi Kurushima, Ken-ichi Aihara, Masashi Akaike, Masashi Kano, Takashi Kitaichi, Yutaka Masuda, Hiroyuki Azuma, Toshiaki Tamaki, Toshio Matsumoto, Tetsuya Kitagawa, Shuhei Tomita and Masanori Yoshizumi :
HIF-ARNT transcriptional system in T cells has a pivotal role in vascular in flammation and remodeling.,
第70回日本循環器学会学術総会, Mar. 2006. Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Hirotsugu Kurobe, Mitsunori Fujimura, Syusuke Yagi, Syunji Hashizume, Yasumasa Ikeda, Takashi Iwase, Nobuyuki Takamori, Tetsuya Kitagawa and Toshio Matsumoto :
Plasma Heparin Cofactor II Activity is Inversely Associated with Prevalence of Peripheral Arterial Disease in Elderly individuals.,
第70回日本循環器学会学術総会, Mar. 2006. Ken-ichi Aihara, Mihara Masatomo, Azuma Hiroyuki, Masashi Akaike, Takaya Matsushita, Yasumasa Ikeda, Shusuke Yagi, Takashi Iwase, Hashizume Shunji, Fujimura Mitsunori and Toshio Matsumoto :
Thrombin inactivation by synthetic thrombin antagonist argatroban ameliorates insulin resistance in type 2 diabetic db/db mice,
The 70th Anniversary Annual Scientific Meetings of the Japanese Circulation Society, Mar. 2006. 黒部裕嗣, 冨田修平, 井澤有紀, 福原弥生, 神原保, 粟飯原賢一, 赤池雅史, 北川哲也, 松本俊夫, 吉栖正典, 玉置俊晃 :
T細胞特異的HIF1αKOマイスではカフモデルにて血管リモデリングが促進される,
第15回日本循環薬理学会, 2005年11月. 山口浩司, 若槻哲三, 福田大和, 小柴邦彦, 河野智仁, 山田博胤, 添木武, 岩瀬俊, 藤村光則, 赤池雅史, 東博之 :
たこつぼ型心筋障害の亜型と考えられた左室mid-portion ballooningの一例,
第87回日本循環器学会中国・四国合同地方会, 2005年11月. 粟飯原賢一, 東博之, 赤池雅史, 黒部裕嗣, 藤村光則, 八木秀介, 橋詰俊二, 池田康将, 岩瀬俊, 北川哲也, 松本俊夫 :
ヘパリンコファクターIIは末梢動脈閉塞症に対する独立した防御因子である,
第28回日本血栓止血学会学術集会, 2005年11月. 粟飯原賢一, 東博之, 赤池雅史, 黒部裕嗣, 佐田政隆, 池田康将, 藤村光則, 橋詰俊二, 岩瀬俊, 八木秀介, 大水章正, 塚田稔, 北川哲也, 加藤茂明, 松本俊夫 :
新規血管リモデリング抑制因子ヘパリンコファクターIIの臨床および分子生物学的解析,
第13回日本血管生物医学会, 2005年10月. 八木秀介, 粟飯原賢一, 赤池雅史, 藤村光則, 池田康将, 橋詰俊二, 東博之, 松本俊夫 :
Pitavastatinは,Angiotensin IIによるマウス冠動脈リモデリングを抑制する,
第37回日本動脈硬化学会総会, 232, 2005年7月.

(キーワード): Angiotensin II 心臓血管疾患(診断,外科的療法,実験的) *Pitavastatin(薬理学) 血管リモデリング頸動脈内膜中膜肥厚度マウス動物

粟飯原賢一, 東博之, 赤池雅史, 池田康将, 藤村光則, 橋詰俊二, 大水正章, 塚田稔, 加藤茂明, 松本俊夫 :
新規血管リモデリング抑制因子ヘパリンコファクターIIの分子生物学的解析,
第37回日本動脈硬化学会総会, 233, 2005年7月.

(キーワード): *Heparin Cofactor II 遺伝子発現血管疾患(病理学,実験的) 分子生物学血管リモデリングマウス動物

粟飯原賢一, 三原正朋, 池田康将, 八木秀介, 藤村光則, 橋詰俊二, 松下隆哉, 赤池雅史, 東博之, 松本俊夫 :
トロンビン作用の阻害は2型糖尿病モデルdb/dbマウスのインスリン抵抗性を改善する,
第78回日本内分泌学会総会学術集会, Vol.81, No.1, 190, 2005年7月.

(キーワード): Thrombin(拮抗物質・阻害物質) *インスリン抵抗性糖尿病-2型(診断,実験的) Argatroban(薬理学) メタボリックシンドローム(病因) マウス動物

池田康将, 粟飯原賢一, 赤池雅史, 八木秀介, 岩瀬俊, 橋詰俊二, 藤村光則, 東博之, 加藤茂明, 松本俊夫 :
アンドロゲン-アンドロゲン受容体システムはドキソルビシンによる心筋酸化ストレスに対して防御的に作用する,
第78回日本内分泌学会総会学術集会, Vol.81, No.2, 548, 2005年7月.

(キーワード): *Androgens(薬理学) Doxorubicin(毒性・副作用) Androgen Receptors(薬理学) *心筋疾患(実験的,化学的誘発) 心臓ミトコンドリア酸化ストレスノックアウトマウスマウス動物オス

八木秀介, 粟飯原賢一, 赤池雅史, 池田康将, 岩瀬俊, 橋詰俊二, 藤村光則, 東博之, 松本俊夫 :
Pitavastatinは,Angiotensin IIによるマウス冠動脈および心筋リモデリングを抑制する,
第78回日本内分泌学会総会学術集会, Vol.81, No.2, 564, 2005年7月.

(キーワード): Angiotensin II 冠血管 C57BLマウス心室リモデリング *Pitavastatin(薬理学) 冠状動脈マウス動物

Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Masataka Sata, Fujimura MItsunori, Hashizume Shunji, Yasumasa Ikeda, Shusuke Yagi, Kawano Hirotaka, Yamada Takashi, Fukuda Tohru, Sekine Keisuke, Sato Takashi, Nakamichi Yuko, Yamamoto Yoko, Yoshimura Kimihiro, Watanabe Tomoyuki, Nakamura Takashi, Ohmizu Akira, Tsukada Minoru, Shigeaki Kato and Toshio Matsumoto :
Heparin cofactor II is required for fetal development and attenuates cuff-injured vascular remodeling in mice,
The 37th Japan Atherosclerosis Society Annual Meeting, Jul. 2005. 粟飯原賢一, 東博之, 赤池雅史, 黒部裕嗣, 藤村光則, 八木秀介, 橋詰俊二, 池田康将, 北川哲也, 松本俊夫 :
ヘパリンコファクターIIは末梢動脈閉塞性病変進展に対する新規抑制因子である,
第102回日本内科学会総会・講演会, Vol.94, No.Suppl., 228, 2005年4月.

(キーワード): *Heparin Cofactor II 血圧測定 *動脈閉塞性疾患(診断) 足関節上腕血圧比ヒト中年(45~64) 高齢者(65~79)

Ken-ichi Aihara, Masashi Akaike, Yasumasa Ikeda, Kato Midori, Fujimura Mitsunori, Hashizume Shunji, Shusuke Yagi, Hiroyuki Azuma and Toshio Matsumoto :
Angiotensin II Antagonist Valsartan Ameliorates Nitric Oxide Bioavailability and Arterial Stiffness Accompanied with The Reduction of Blood Pressure and Pulse Pressure in Elderly Hypertensives,
第69回日本循環器学会総会・学術集会, Mar. 2005. Ken-ichi Aihara, Masashi Akaike, Yasumasa Ikeda, Shusuke Yagi and Toshio Matsumoto :
Arterial Cuff Injury Causes Enhanced Neointimal Formation and Increased Adventitial Area in Heterozygous Heparin Cofactor II Deficient Mice,
第69回日本循環器学会総会・学術集会, Mar. 2005. 池田康将, 粟飯原賢一, 赤池雅史, 藤村光則, 八木秀介, 橋詰俊二, 東博之, 加藤茂明, 松本俊夫 :
アンドロゲン-アンドロゲン受容体系は生体の心筋防御機構である,
第42回日本臨床分子医学会学術総会, 78, 2005年.

(キーワード): *Androgens Angiotensin II Androgen Receptors 心筋 *心室リモデリングマウス動物オス

粟飯原賢一, 東博之, 赤池雅史, 池田康将, 藤村光則, 橋詰俊二, 八木秀介, 加藤茂明, 松本俊夫 :
ヘパリンコファクターII欠乏マウスにおける血管リモデリング異常の解析,
第27回日本血栓止血学会学術集会, 2004年11月. 粟飯原賢一, 東博之, 赤池雅史, 藤村光則, 吉田智則, 橋詰俊二, 加藤みどり, 池田康将, 周藤俊樹, 加藤茂明, 松本俊夫 :
ビタミンD-ビタミンD受容体システムによる血液凝固調節作用の解析,
第77回日本内分泌学会学術総会, Vol.80, No.1, 138, 2004年6月.

(キーワード): Thromboplastin *Vitamin D(薬理学) 遺伝子発現血液凝固血小板凝集 Calcitriol Receptors マウス動物

池田康将, 粟飯原賢一, 赤池雅史, 森岡将臣, 加藤みどり, 橋詰俊二, 山口普史, 藤村光則, 吉田智則, 東博之, 加藤茂明, 松本俊夫 :
アンドロゲン-アンドロゲン受容体システムは生体における心筋肥大及び心筋線維化の調節因子である,
第77回日本内分泌学会学術総会, Vol.80, No.1, 96, 2004年6月.

(キーワード): Androgens Androgen Receptors 心筋疾患 *心筋症-肥大性(診断,病理学,実験的) 線維症ノックアウトマウス心筋線維症(診断,病理学,実験的) マウス動物

山口普史, 七條加奈, 松下隆哉, 池田康将, 森岡将臣, 加藤みどり, 橋詰俊二, 藤村光則, 吉田智則, 粟飯原賢一, 井上大輔, 赤池雅史, 東博之, 松本俊夫 :
拡張型心筋症様病態を呈したCushing病の一例,
第83回日本循環器学会中国・四国合同地方会, Vol.68, No.0, 828, 2004年4月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573387451866119936

(CiNii: 1573387451866119936) 池田康将, 山口普史, 七條加奈, 森岡将臣, 加藤みどり, 橋詰俊二, 吉田智則, 藤村光則, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫, 木村建彦, 西内健 :
Torsade de pointesを合併した汎下垂体機能低下症の一例,
第83回日本循環器学会中国・四国合同地方会, Vol.68, No.0, 828, 2004年4月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571135652052441728

(CiNii: 1571135652052441728) 橋詰俊二, 池田康将, 加藤みどり, 山口普史, 吉田智則, 藤村光則, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫 :
核内受容体PPARαの活性化は巨核球/血小板内PDGF-BBの産生を抑制する,
第36回日本動脈硬化学会総会, 196, 2004年.

(キーワード): *血小板由来増殖因子巨核球血小板培養腫瘍細胞白血病-急性赤芽球性細胞質受容体と核内受容体 *ペルオキシソーム増殖因子活性化受容体ヒト in vitro

粟飯原賢一, 高森信行, 金川泰彦, 藤村光則, 加藤みどり, 橋詰俊二, 池田康将, 田村克也, 近藤彰, 赤池雅史, 東博之, 松本俊夫 :
ヘパリンコファクターIIの動脈硬化抑制作用に関する臨床的検討,
第41回日本臨床分子医学会学術総会, 55, 2004年.

(キーワード): *Heparin Cofactor II Serine Proteinase Inhibitors(血液) ステント *動脈硬化症血管平滑筋細胞増殖 Cofactor ヒト

山口普史, 池田康将, 橋詰俊二, 加藤みどり, 吉田智則, 藤村光則, 粟飯原賢一, 赤池雅史, 東博之, 松本俊夫 :
遺伝性出血性末梢血管拡張症9家系における臨床病型と遺伝子変異に関する解析,
第25回日本血栓止血学会学術集会, Vol.14, No.5, 456, 2003年11月.

(キーワード): 遺伝性疾患出血変異 *毛細血管拡張症-遺伝性出血性(診断,遺伝学) 遺伝学的検査骨形成因子受容体I型ヒト

粟飯原賢一, 東博之, 赤池雅史, 高森信行, 金川泰彦, 藤村光則, 吉田智則, 橋詰俊二, 加藤みどり, 山口普史, 池田康将, 加藤修司, 荒瀬友子, 近藤彰, 松本俊夫 :
ヘパリンコファクターIIは高齢者における新規動脈硬化抑制因子である,
第25回日本血栓止血学会学術集会, Vol.14, No.5, 439, 2003年11月.

(キーワード): Antithrombins *Heparin Cofactor II(薬理学) HDL Cholesterol 動脈硬化症(診断,予防) 高齢者 Lipoprotein(a) ヒト中年(45~64) 高齢者(65~79) 高齢者(80~) 男女

Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Fujimura Mitsunori, Sudo Toshiki, Hayashi Hideki, Yamada Yoshihisa, Yoshida Tomonori, Yamaguchi Hiroshi, Hashizume Shunji, Kato Midori and Toshio Matsumoto :
Vitamin D/Vitamin D Receptor System Regulates Antithrombogenicity in vivo,
第68回日本循環器学会総会学術集会, Mar. 2003. Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma, Toshio Matsumoto, Michiko Yamashita, Yoshimura Kimihiro and Imagawa Jun-ichi :
Elevated blood pressure with a cardiovascular remodeling in mice lacking vitamin D receptor,
第66回日本循環器学会総会・学術集会, Apr. 2002. 高森信行, 橋詰俊二, 加藤みどり, 吉田智則, 粟飯原賢一, 松山まどか, 石川カズ江, 藤村光則, 金川泰彦, 赤池雅史 :
ヘパリンコファクターIIと動脈硬化発症との関連性甲状腺機能異常症患者での解析,
第22回日本血栓止血学会学術集会, Vol.11, No.5, 485, 2000年11月.

(キーワード): Heparin Cofactor II 動脈硬化症甲状腺機能正常患者症候群ヒト

赤池雅史, 東博之, 香川礼香, 井内貴彦, 藤村光則, 橋詰俊二, 高森信行, 吉田智則, 粟飯原賢一, 金川泰彦, 松本俊夫, 松本和也, 林郁郎, 田村克也, 西内健 :
血中リポ蛋白(a)濃度に及ぼすアスピリンの影響 : アポリポ蛋白(a)アイソフォーム解析を用いた検討,
第64回日本循環器学会学術集会, Vol.64, No.0, 427, 2000年3月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570291227165355136

(CiNii: 1570291227165355136) 高森信行, 橋詰俊二, 金川泰彦, 粟飯原賢一, 吉田智則, 井内貴彦, 赤池雅史, 東博之, 松本俊夫 :
ヘパリンコファクターIIと動脈硬化発症の関連性,
第21回日本血栓止血学会学術集会, Vol.10, No.5, 393, 1999年11月.

(キーワード): Heparin Heparin Cofactor II(生理学) 動脈硬化症 Cofactor ヒト中年(45~64) 高齢者(65~) 男女

金川泰彦, 粟飯原賢一, 高森信行, 吉田智則, 井内貴彦, 赤池雅史, 重清俊雄, 東博之, 松本俊夫 :
Pro443からLeuへの変異を有する先天性ヘパリンコファクター(HC)II欠乏症の分子機構の解明,
第21回日本血栓止血学会学術集会, Vol.10, No.5, 355, 1999年11月.

(キーワード): Heparin(欠損・欠乏) 血液蛋白質障害(発生学・遺伝学) 変異 Cofactor ヒト

赤池雅史, 井内貴彦, 高森信行, 粟飯原賢一, 吉田智則, 金川泰彦, 遠藤逸朗, 三ツ井貴夫, 東博之, 重清俊雄, 松本俊夫 :
先天性ヘパリンコファクターII(HC II)欠乏症でみられた多発性動脈病変 : 動脈硬化症の進展におけるHCIIの臨床的意義の検討,
第63回日本循環器学会学術集会, Vol.63, No.1, 645, 1999年3月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1574231876839482624

(CiNii: 1574231876839482624) 赤池雅史, 東博之, 高森信行, 松本和也, 林郁郎, 田村克也, 西内健, 粟飯原賢一, 金川泰彦, 井内貴彦 :
高リポ蛋白(a)血症に及ぼすアスピリンの影響アポリポ蛋白(a)アイソフォームとの関連,
動脈硬化, Vol.26, No.8, 137, 1999年.

(キーワード): Aspirin 高リポ蛋白質血症(生化学) Lipoprotein(a) 蛋白質アイソフォームヒト

赤池雅史, 井内貴彦, 高森信行, 粟飯原賢一, 吉田智則, 金川泰彦, 遠藤逸朗, 三ツ井貴夫, 東博之, 重清俊雄 :
先天性ヘパリンコファクターII(HC II)欠乏症でみられた多発性動脈病変動脈硬化症の進展におけるHCIIの臨床的意義の検討,
Japanese Circulation Journal, Vol.63, No.Suppl.I, 645, 1999年.

(キーワード): Heparin Cofactor II(欠損・欠乏) 動脈硬化症(先天性) ヒト

赤池雅史, 東博之, 香川礼香, 金川泰彦, 粟飯原賢一, 井内貴彦, 高森信行, 吉田智則, 松本俊夫, 松本和也 :
高リポ蛋白(a)血症に及ぼすaspirinの影響アポリポ蛋白(a)アイソフォームとの関連,
四国医学雑誌, Vol.55, No.2, 82, 1999年.

(キーワード): Apolipoproteins A Aspirin 高リポ蛋白質血症蛋白質アイソフォームヒト
(徳島大学機関リポジトリ): ● Metadata: 112136

(徳島大学機関リポジトリ: 112136) 赤池雅史, 東博之, 松本和也, 林郁郎, 田村克也, 西内健, 香川礼香, 金川泰彦, 粟飯原賢一, 井内貴彦 :
血中リポ蛋白(a)濃度に及ぼすアスピリンの影響アポ蛋白(a)アイソフォームとの関連,
日本内分泌学会雑誌, Vol.75, No.1, 175, 1999年.

(キーワード): Aspirin Lipoprotein(a)(血液,薬物影響) Apoprotein(a) ヒト in vitro

赤池雅史, 金川泰彦, 香川礼香, 吉田智則, 粟飯原賢一, 東博之, 松本俊夫, 松本和也 :
高Lp(a)血症に及ぼすaspirinの影響 Lp(a)アイソフォーム解析を用いた検討,
日本内科学会雑誌, Vol.88, 139, 1999年.

(キーワード): Aspirin(薬理学) Lipoprotein(a)(血液,薬物影響,代謝性障害) ヒト

金川泰彦, 重清俊雄, 粟飯原賢一, 松山まどか, 香川礼香, 宮本和正, 井内貴彦, 赤池雅史, 東博之, 松本俊夫 :
先天性ヘパリンコファクターII(HCII)欠乏症1家系の遺伝子解析,
第20回日本血栓止血学会学術集会, Vol.9, No.4, 315, 1998年11月.

(キーワード): Heparin Cofactor II(欠損・欠乏) 血液蛋白質障害配列分析ヒト

柴田泰伸, 若槻真紀, 加部一行, 赤池雅史, 新谷保実, 齋藤史郎, 吉本勝彦, 川人智久, 筑後文雄, 堀隆樹, 北川哲也 :
僧帽弁に粘液腫様変性が認められた先端巨大症合併MEN 1型の1例,
第208回徳島医学会(平成5年度冬期総会), 1994年1月. 新谷保実, 吉本勝彦, 金崎淑子, 赤池雅史, 堀江秀茂, 細井恵美子, 横越浩, 板東浩, 山崎柳一, 依田啓司, 松本圭蔵, 佐野壽昭, 齋藤史郎 :
MEN I型のGHRH産生膵腫瘍に見い出されたGH分泌下垂体腫瘍,
第66回日本内分泌学会学術総会(金沢), 1993年6月.

研究会・報告書

吉田守美子, 粟飯原賢一, 赤池雅史, 松本俊夫 :
ステロイド性大腿骨頭壊死症予防に向けた，大量グルココルチコイドによる酸化ストレスおよび血管内皮機能の変化と，ピタバスタチンの臨床的有効性の検討,
特発性大腿骨頭壊死症の治療法確立と革新的予防法開発にむけた全国学術研究, 2016年8月. 村上貴寛, 八木秀介, 原知也, 伊勢孝之, 楠瀬賢也, 松浦朋美, 飛梅威, 山口浩司, 山田博胤, 添木武, 若槻哲三, 島袋充生, 赤池雅史, 春藤譲治, 佐田政隆 :
原発性アルドステロン症の診断に有用な臨床所見の検討,
第253回徳島医学会学術集会(平成28年度夏期), 2016年7月. 粟飯原賢一, 赤池雅史, 吉田守美子, 松本俊夫 :
グルココルコイド過剰誘導酸化ストレスの臨床的評価とeNOSの有無におけるピタバスタチンの虚血臓器保護効果機構の差異,
厚生労働科学研究費補助金平成27年度第1回班会議, 2015年8月. 粟飯原賢一, 吉田守美子, 池田康将, 赤池雅史, 加藤茂明, 松本俊夫 :
虚血耐性における性差非依存性のアンドロゲン受容体作用,
第5回核内受容体・ホルモン研究会, 2013年3月. 粟飯原賢一, 赤池雅史, 吉田守美子, 松本俊夫 :
Pitavastatinは血管内皮機能障害を背景にした重症虚血誘導組織壊死を抑制する,
厚生労働科学研究費補助金難治性疾患克服研究事業特発性大腿骨頭壊死症調査研究班平成24 年度第2回班会議, 2013年1月. 粟飯原賢一, 赤池雅史, 吉田守美子, 松本俊夫 :
血管内皮機能障害を背景にした重症虚血誘導組織壊死に対するpitavastatinの効果,
厚生労働科学研究費補助金難治性疾患克服研究事業特発性大腿骨頭壊死症調査研究班平成24 年度第1回班会議, 2012年8月. 吉田守美子, 粟飯原賢一, 池田康将, 赤池雅史, 加藤茂明, 松本俊夫 :
アンドロゲン受容体は，虚血ストレスに対する骨格筋アポトーシス防御および血管新生に必須である,
第4回核内受容体研究会, 2012年4月. 坂東美佳, 山田博胤, 西尾進, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 玉井利奈, 平田有紀奈, 弘田大智, 小笠原梢, 髙島啓, 山崎宙, 坂東左知子, 伊勢孝之, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
質低下療法による頸動脈プラーク安定化の評価,
第5回T0kushima Young Investigators Conference, 2012年3月. 粟飯原賢一, 赤池雅史, 吉田守美子, 松本俊夫 :
酸化ストレス抑制作用を介したグルココルチコイド誘発性血管内皮細胞障害治療,
厚生労働科学研究費補助金難治性疾患克服研究事業特発性大腿骨頭壊死症調査研究班平成23 年度第2回班会議, 2011年12月. 岩瀬俊, 伊勢孝之, 小笠原梢, 山崎宙, 高島啓, 坂東左知子, 仁木敏之, 楠瀬賢也, 發知淳子, 冨田紀子, 上田由佳, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 髙尾正一郎, 能勢隼人, 原田雅史, 赤池雅史, 足立克仁 :
Duchenne型筋ジストロフィー女性キャリアの心病変検出における心臓MRI検査の有用性,
第16回中四国心筋症・心不全研究会, 2011年9月. 原知也, 岩瀬俊, 高島啓, 山崎宙, 小笠原梢, 坂東左知子, 伊勢孝之, 仁木敏之, 楠瀬賢也, 上田由佳, 冨田紀子, 山口浩司, 竹谷善雄, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 赤池雅史, 能勢隼人, 髙尾正一郎, 大塚秀樹, 原田雅史, 西岡安彦 :
心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討,
第16回中四国心筋症・心不全研究会, 2011年9月. 赤池雅史, 粟飯原賢一, 吉田守美子, 松本俊夫 :
グルココルチコイド誘発性血管内皮細胞障害に対する酸化ストレス抑制の意義,
厚生労働科学研究費補助金難治性疾患克服研究事業特発性大腿骨頭壊死症調査研究班平成23 年度第1回班会議, 2011年8月. 清水拓, 楠瀬賢也, 山田博胤, 西尾進, 玉井利奈, 遠藤桂輔, 佐藤光代, 河野裕美, 赤池雅史, 佐田政隆 :
運動負荷心エコー法を用いた膠原病例における潜在性肺動脈性高血圧症の検出,
第2回徳島肺高血圧研究会, 2011年4月. 吉田守美子, 粟飯原賢一, 池田康将, 赤池雅史, 加藤茂明, 松本俊夫 :
アンドロゲン受容体は，虚血ストレスに対する骨格筋アポトーシス防御および血管新生に必須である,
第3回核内受容体研究会帝人ファーマ株式会社, 2011年3月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
エイコサペンタエン酸の心血管リモデリング抑制効果の検討,
第3回Tokushima Young Investigators Conference, 2011年3月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
EPAによる心血管リモデリング抑制効果の検討,
第30回心血管セミナー, 2011年1月. 遠藤桂輔, 山田博胤, 楠瀬賢也, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 齋藤憲, 佐田政隆 :
陳旧性心筋梗塞症における心電図左房負荷所見の意義:心エコー・ドプラ法を用いた検討,
心・血管クラスターミニリトリート, 2011年1月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 林修司, 三木淳子, 仁木敏之, 山口浩司, 岩瀬俊, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
左室内同期不全に対する前負荷の影響拡張型心筋症における下肢陽圧負荷3次元心エコー法を用いた検討,
先進血管エコー研究会, 2010年8月. 遠藤桂輔, 山田博胤, 西尾進, 冨田紀子, 楠瀬賢也, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 玉井利奈, 山口浩司, 竹谷善雄, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 齋藤憲 :
心電図異常を指摘され，心エコー検査で発見された左室緻密化障害の1例,
第3回蔵本エコーカンファレンス, 2010年7月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
虚血および血管新生におけるアンドロゲン作用の検討,
興和学術講演会, 2010年5月. 粟飯原賢一, 吉田守美子, 池田康将, 赤池雅史, 加藤茂明, 松本俊夫 :
心血管ストレスに対するandrogen-androgen 受容体系の役割,
第2回核内受容体研究会, 2010年3月. 吉田守美子, 粟飯原賢一, 上田由佳, 池田康将, 倉橋清衛, 木内美瑞穂, 遠藤逸朗, 藤中雄一, 岩瀬俊, 赤池雅史, 佐田政隆, 松本俊夫 :
下肢虚血モデルを用いたアンドロゲン受容体による虚血臓器保護効果の検討,
第15回徳島内分泌研究会, 2009年11月. 楠瀬賢也, 山田博胤, 西尾進, 冨田紀子, 遠藤桂輔, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 竹谷善雄, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆 :
心房細動におけるE/e'の計測法:dual Doppler法を用いた検討,
第8回先進血管エコー研究会, 2009年8月. 倉橋清衛, 中村信元, 吉田守美子, 遠藤逸朗, 粟飯原賢一, 藤中雄一, 松本俊夫, 八木秀介, 岩瀬俊, 赤池雅史, 佐田政隆 :
一酸化炭素中毒を契機に発見された急性心筋梗塞の一例,
第9回徳島総合診療研究会, 2009年7月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
第11回徳島脳卒中研究会, 2009年2月. 山中森晶, 山田博胤, 楠瀬賢也, 冨田紀子, 仁木敏之, 山口浩司, 小柴邦彦, 八木秀介, 岩瀬俊, 添木武, 若槻哲三, 赤池雅史, 佐田政隆, 西尾進 :
脳卒中患者における心エコー検査の現状:徳島大学病院SCU搬送例における検討,
脳卒中研究会, 2009年2月. 粟飯原賢一, 東博之, 赤池雅史, 池田康将, 八木秀介, 住友由佳, 吉田守美子, 伊勢孝之, 岩瀬俊, 松本俊夫 :
新規血管リモデリング抑制因子ヘパリンコファクターIIの分子生物学的解析,
第9回四国循環器研究会, 2007年9月. 赤池雅史, 川野卓二, 宮田政徳, 吉田博, 新原将義, 上田勇仁, 上岡麻衣子 :
2017年度徳島大学全学FD推進プログラムの実施報告,
大学教育研究ジャーナル, No.15, 77-99, 2018年3月.

(徳島大学機関リポジトリ): ● Metadata: 110954
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762396487040

(徳島大学機関リポジトリ: 110954, CiNii: 1050845762396487040) 赤池雅史, 川野卓二, 宮田政徳, 吉田博, 新原将義, 上岡麻衣子, 久保田祐歌 :
2016年度徳島大学全学FD推進プログラムの実施報告,
大学教育研究ジャーナル, No.14, 99-119, 2017年3月.

(要約): 全学FD 推進プログラムは2002 年度から開始され，FD の体系化，組織化，日常化等を推進してきた．2016 年度は，例年開催している，「授業設計ワークショップ」，「授業参観・授業研究会」，「大学教育カンファレンスin 徳島」，「ティーチング・ポートフォリオ作成ワークショップ」の他に，各学部等におけるFD の実態を把握し，成果や課題を明らかにした上で，ニーズの明確化，今後の学部等FD と総合教育センターの支援の在り方について検討するために，「質保証のための分野別ワークショップ」を開催した．また，大学教育再生加速プログラムに関連するSIH 道場FD・説明会の実施や学内でアクティブ・ラーニングを推進するためにLED カフェ等を実施した．各プログラムについて概要を記載し，アンケート結果等から成果と今後の課題について考察する．
(キーワード): 質保証 / 分野別ワークショップ / 大学教育再生加速プログラム / 授業参観・授業研究会 / 大学教育カンファレンス / Quality Assurance / Disciplinary Workshop / Acceleration Program for University Education / Classroom Observation & Discussion Meeting / University Education Conference
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762396369920

(CiNii: 1050845762396369920)

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: AIを用いた対話型医療面接トレーニングシステムの開発 (研究課題/領域番号: 22K10363 )
診療参加型臨床実習に必要とされる汎用的能力の研究 (研究課題/領域番号: 21K10351 )
クリニカル・クラークシップでの新たな診療現場指導・評価法導入による教育効果の研究 (研究課題/領域番号: 18K10004 )
医療安全能力向上のための未固定遺体とシミュレータを用いた教育プログラムの研究 (研究課題/領域番号: 17K08918 )
３６０度コミュニケーション能力の修得を目指した臨床実習準備教育プログラムの開発 (研究課題/領域番号: 15K08554 )
スキルス・ラボの海外交流プログラムによる国際感覚育成に関する研究 (研究課題/領域番号: 26460603 )
ヘパリンコファクターIIによる心リモデリングおよびインスリン抵抗性制御機構の解析 (研究課題/領域番号: 21591140 )
ミネラルコルチコイド受容体を介したグルココルチコイドによる血管内皮障害機構の解明 (研究課題/領域番号: 21590955 )
血管内皮機能を標的としたグルココルチコイド誘発性血管障害に対する新規治療法の開発 (研究課題/領域番号: 19590866 )
ヘパリンコファクターIIの動脈硬化進展抑制に対するトランスレーショナルリサーチ (研究課題/領域番号: 18590816 )
BMK1/ERK5による新たな血管内皮機能制御機構の解明と動脈硬化症治療への応用 (研究課題/領域番号: 17590740 )
骨格系のホメオスターシス維持と病態発症に関わる分子制御機構の解明と治療法の開発 (研究課題/領域番号: 17209035 )
ヘパリンコファクターIIの新規動脈硬化・血栓症抑制作用の発見と臨床応用に関する研究 (研究課題/領域番号: 16590692 )
グルココルチコイド受容体活性化を介したミトコンドリア障害機序の解明 (研究課題/領域番号: 14570601 )
トロンビンによる活性酸素産生亢進を介した血管障害に関する研究 (研究課題/領域番号: 12670674 )
活性酸素によるミトコンドリア障害の病態解析:ステロイド筋症とミトコンドリア脳筋症での検討 (研究課題/領域番号: 12670606 )
ミトコンドリアでの活性酵素産生亢進による心血管系病変の発症に関する研究(グルココルチコイド過剰症における検討) (研究課題/領域番号: 10670663 )
高リポ蛋白(a)血症に対するapo(a)遺伝子の転写活性を指標とした治療薬の開発(apo(a)遺伝子プロモーター導入細胞を用いたスクリーニング) (研究課題/領域番号: 10557105 )
遺伝性出血性毛細血管拡張症の遺伝子変異と発症機構の解明ならびに病型解折法の確立 (研究課題/領域番号: 09671117 )
高リポ蛋白(a)血症に対する治療薬の作用機序の解明と新しい治療薬のスクリーニング (研究課題/領域番号: 07807072 )
脳性ナトリウム利尿ペプチドによる筋ジストロフィー患者の心機能評価 (研究課題/領域番号: 07770510 )
研究者番号（90271080）による検索

その他: 研究者総覧に該当データはありませんでした。

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2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
所属学会・所属協会: 日本老年医学会
日本医学教育学会
社団法人日本内科学会
社団法人日本循環器学会
委員歴・役員歴: 日本老年医学会 (代議員 [2009年6月〜2015年6月])
日本医学教育学会 (選挙代議員 [2013年6月〜2015年6月])
社団法人日本内科学会 (四国支部運営協議会委員 [2013年4月〜2016年3月])
社団法人日本内科学会 (四国支部評議員 [2006年4月〜2016年3月])
社団法人日本循環器学会 (四国支部評議員 [2006年4月〜2016年3月])
日本医学教育学会 (教育業績評価委員会委員 [2012年4月〜2016年3月])
社団法人日本循環器学会 (医療事故調査制度日本循環器学会四国支部幹事 [2015年11月〜2018年3月])
受賞: 1999年8月, 第2回徳島医学会賞 (徳島医学会)
2005年, 医学優秀教育賞(徳島大学医学部) (徳島大学医学部)
2006年, Best Teacher of the Year 2006賞(徳島大学医学部医学科) (徳島大学医学部)
2014年7月, 第248回徳島医学会学術集会(平成25年度冬期) 若手奨励賞 (徳島医学会)
2014年11月, 第47回塩田賞 (国立医療学会)
2015年2月, 日本心臓財団・日本循環器学会「心臓」優秀査読賞 (医学部教授)
2016年7月, 第253回徳島医学会学術集会(平成28年度夏期)「若手奨励賞」 (徳島医学会)
活動: 社団法人徳島県医師会 (男女共同参画委員会委員 [2012年4月〜2024年3月])
徳島市医師会 (糖尿病対策委員会委員 [2007年4月〜2017年3月])
徳島市医師会 (女性医師プロジェクト委員会委員 [2009年4月〜2017年3月])
徳島県 (総合計画審議会委員 [2015年4月〜2016年3月])
厚生労働省 (医師試験委員 [2012年4月〜2015年3月])
社団法人医療系大学間共用試験実施評価機構 (医学系OSCE専門部会委員 [2014年4月〜2015年3月])
独立行政法人大学評価・学位授与機構 (大学機関別認証評価委員会専門委員 [2014年4月〜2016年3月])
一般社団法人日本医学教育評価機構 (調査・解析委員会委員 [2015年12月〜2024年3月])
JA徳島厚生連 (新たなJA徳島厚生連病院のあり方検討会委員 [2013年12月〜2016年3月])
阿南工業高等専門学校 (大学教育再生加速プログラム評価委員会委員 [2015年11月〜2017年3月])
一般社団法人日本医学教育評価機構 (評価員 [2015年4月〜2024年3月])
徳島県立中央病院 (臨床研修管理委員会委員 [2010年4月〜2017年3月])
阿南共栄病院 (臨床研修管理委員会委員 [2010年4月〜2017年3月])
徳島県鳴門病院 (臨床研修管理委員会委員 [2011年4月〜2016年3月])
学部長 (2019年4月〜2022年3月)
研究部長 (2022年4月〜2026年3月)

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Ｊグローバル

Jグローバル最終確認日: 2024/11/9 01:13
氏名（漢字）: 赤池雅史
氏名（フリガナ）: アカイケマサシ
氏名（英字）: Akaike Masashi
所属機関: 徳島大学教授

リサーチマップ

researchmap最終確認日: 2024/11/10 01:13
氏名（漢字）: 赤池雅史
氏名（フリガナ）: アカイケマサシ
氏名（英字）: Akaike Masashi
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登録日時: 2008/7/30 00:00
更新日時: 2024/9/19 16:05
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所属: 徳島大学
部署: 大学院医歯薬学研究部医療教育学
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2024年11月9日更新

研究者番号: 90271080

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2022/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 教授
2015/4/1 : 徳島大学, 大学院医歯薬学研究部, 教授
2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2010/4/1 – 2011/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2008/4/1 – 2009/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授
2007/4/1 : 徳島大学, 医学部歯学部附属病院, 講師
2007/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師
2006/4/1 – 2007/4/1 : 徳島大学, 医学部・歯学部附属病院, 講師
2006/4/1 : 徳島大学, 医学部・歯学部・附属病院, 講師
2006/4/1 : 徳島大学, 医学部・歯学附属病院, 講師
2005/4/1 : 徳島大学, 医学部・歯学部・附属病院, 助手
2003/4/1 – 2005/4/1 : 徳島大学, 医学部・歯学部附属病院, 助手
2002/4/1 : 徳島大学, 医学部附属病院, 助手
1999/4/1 – 2001/4/1 : 徳島大学, 医学部・附属病院, 助手
1998/4/1 : 徳島大学, 医学部付属病院, 助手
1998/4/1 : 徳島大学, 医学部附属病院, 助手
1995/4/1 : 徳島大学, 医学部・付属病院, 助手
1995/4/1 : 徳島大学, 医学部・附属病院, 助手

審査区分/研究分野

研究代表者

医学 / 内科 / 循環器内科学
生物系 / 医歯薬学 / 内科系臨床医学 / 循環器内科学
生物系 / 医歯薬学 / 境界医学 / 医療社会学
小区分58010:医療管理学および医療系社会学関連

研究代表者以外

医学 / 内科 / 循環器内科学
生物系 / 医歯薬学 / 内科系臨床医学 / 代謝学
生物系 / 医歯薬学 / 境界医学 / 医療社会学
医学 / 内科 / 血液内科学
医学 / 内科 / 代謝学
医学 / 内科 / 神経内科学
生物系 / 医歯薬学 / 内科系臨床医学 / 循環器内科学
生物系 / 医歯薬学 / 内科系臨床医学 / 内分泌学
小区分58010:医療管理学および医療系社会学関連

キーワード

研究代表者

脳性ナトリウム利尿ペプチド / 筋ジストロフィー / 心機能 / 心不全 / 血管内皮機能 / 酸化ストレス / 活性酸素 / 一酸化窒素 / 一酸化窒素合成酵素 / グルココルチコイド / スタチン / ERK5 / KLF2 / HMGCoA還元酵素阻害薬 / 血管内皮細胞 / 高血圧 / 多面的作用 / ゲラニルゲラニルピリン酸 / ミネラルコルチコイド / ミトコンドリア / 電子伝達系 / 高血圧症 / 血管平滑筋細胞 / 動脈硬化症 / 血管平滑筋 / Mitochondria / Respiratory chain / Reactive oxygen species / Glucocorticoid / Vascular endothelial cell / Vascular smooth muscle cell / Hypertension / Atherosclerosis / トロンビン / アスピリン / reactive oxygen species / vascular endothelial cells / thrombin / mitochondria / repiratory chain / aspirin / BMK1 / 炎症 / 動脈硬化 / PPARγ / VCAM-1 / vascular endothelial function / statin / inflammation / nitric oxide synthase / pleiotropic effect / atherosclerosis / 臨床実習準備教育 / 診療参加型臨床実習 / クリニカル・クラークシップ / コミュニケーション / シミュレーション / クリニカルクラークシップ / 診療現場評価 / 汎用的能力

研究代表者以外

リポプロテイン(a) / アポリポプロテイン(a) / 動脈硬化 / 転写 / ルシフェラーゼ / ニコチン酸 / 高脂血症 / ヘパリンコファクターII / トロンビン / 心筋リモデリング / インスリン抵抗性 / メタボリックシンドローム / 2型糖尿病 / 国際感覚育成 / 英語実習 / スキルスラボ / シミュレーション教育 / ノンテクニカルスキル / Basic life support / 縫合実習 / アクティブラーニング / Basic　life　support / HHT / TGF-β / エンドグリン / Smad / HGF-β / 遺伝性出血性毛細血管拡張症 / 毛細血管 / TGF-beta / Endoglin / リポ蛋白(a) / アポ蛋白(a) / アスピリン / 転写因子 / 血管内皮細胞 / 肝細胞 / 血管内及細胞 / IL-6 / 転写活性 / lipoprotein (a) / apolipoprotein (a) / atherosclerosis / aspirin / transcriptional factor / hepatocyte / endothelial cell / ミトコンドリア障害 / ステロイド筋症 / ミトコンドリア脳筋症 / 活性酸素 / Mitochondrial damage / Corticosteroid myopathy / Mitochondrial encephalomyopathy / Reactive oxigen species / 活性酸素種 / スーパーオキサイドジスムターゼ / アポトーシス / グルココルチコイド / グルココルチコイド受容体 / 神経細胞 / 筋細胞 / reactive oxygen species / superoxide dismutase / mitochondrial dysfunction / apoptosis / 冠動脈インターベンション / ノックアウトマウス / 血管リモデリング / 血管平滑筋細胞 / トロンビン受容体 / PCI / PAR / thrombin / heparin cofactor II / coronary intervention / knockout mice / vascular remodeling / vascular smooth muscle cell / thrombin receptor / 力学的負荷 / IL-11 / ΔFosB / 骨髄腫 / Wnt / 血管新生 / 血管内皮機能 / g / DeltaFosB / Mechanical stress / Interleukin-11 (IL-11) / AFosB / Multiple myeloma / Wnt signal / Angiogenesis / Gluencorticoid / Endothelial cells / ヘパリンコファクターII(HCII) / 遺伝子欠損マウス / 胎生致死 / 血栓形成 / 欠損マウス / heparin cofactor II(HCII) / embryonic lethality / thrombosis / 医療安全教育 / スキルス・ラボ / 未固定遺体 / HoloLens / バーチャルシミュレータ / 局所解剖理解 / 低侵襲手術トレーニング / 腹腔鏡下手術 / トレーニングプログラム / 医療安全 / クリニカル・クラークシップ / 没入体験 / HoloLenz / 低侵襲手術 / トレーニング / ドライラボ / 腹腔鏡下腹腔内血管画像 / 言語理解 / 知能情報 / 医療面接 / AI / 自学自習 / 音声認識 / 医療面接トレーニング

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研究者を探す

赤池 雅史

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研究代表者

研究代表者以外

研究代表者

研究代表者以外

赤池雅史