トップ研究者を探す動脈壁と血管周囲脂肪組織に生じる無菌的慢性炎症の病態解明と新規制御法の開発

動脈壁と血管周囲脂肪組織に生じる無菌的慢性炎症の病態解明と新規制御法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16H05299
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 徳島大学
代表研究者 佐田 政隆
研究分担者 福田 大受
研究分担者 添木 武
研究分担者 平田 陽一郎
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 17,550,000 (直接経費 :13,500,000、間接経費 :4,050,000)
配分額(履歴) 2018年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2017年度:4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
2016年度:9,230,000 (直接経費 :7,100,000、間接経費 :2,130,000)
キーワード 慢性炎症
動脈硬化
メタボリックシンドローム
インスリン抵抗性
肥満
自然免疫
自己核酸
糖尿病
脂肪
生活習慣病
脂肪組織
循環器・高血圧
血管

研究成果

[雑誌論文] Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease

Saito Yuko、Yamada Hirotsugu、Kusunose Kenya、Saito Ken、Sata Masataka 2019

[雑誌論文] Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ―

Kajikawa Masato、Noma Kensuke、Nakashima Ayumu、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al. 2019

[雑誌論文] Simultaneous Pulmonary Arterial and Venous Round Structures in Pulmonary Aspergillosis

Yagi Shusuke、Yamazaki Hiromu、Nishio Susumu、Kusunose Kenya、Yamada Hirotsugu、Sata Masataka 2019

[雑誌論文] Sequential speckle tracking imaging to detect early stage of cancer therapeutics-related cardiac dysfunction in a patient with breast cancer

Saijo Yoshihito、Kusunose Kenya、Yamada Nao、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Sata Masataka 2019

[雑誌論文] Recurrent venous thromboembolism after discontinuation of rivaroxaban therapy in a patient with antiphospholipid syndrome

Yagi Shusuke、Nishiyama Seiichi、Abe Toshio、Sata Masataka 2019

[雑誌論文] Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome

Yagi Shusuke、Kondo Daisuke、Yamaguchi Koji、Wakatsuki Tetsuzo、Kawabata Yutaka、Ito Hiroyuki、Saijo Yoshihito、Seno Hiromitsu、Sutou Kumiko、Ueno Rie、Todoroki Takafumi、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Aihara Ken-ichi、Akaike Masashi、Sata Masataka 2019

[雑誌論文] Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire-mediated vascular injury

Hara Tomoya、Fukuda Daiju、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Shimabukuro Michio、Sata Masataka 2018

[雑誌論文] Provocation of clinically significant left ventricular outflow tract obstruction by postural change in patients with sigmoid septum

Hirata Yukina、Yamada Hirotsugu、Kusunose Kenya、Nishio Susumu、Torii Yuta、Horike Yuki、Sata Masataka 2018

[雑誌論文] Development and validation of optimal cut-off value in inter-arm systolic blood pressure difference for prediction of cardiovascular events

Hirono Akira、Kusunose Kenya、Kageyama Norihito、Sumitomo Masayuki、Abe Masahiro、Fujinaga Hiroyuki、Sata Masataka 2018

[雑誌論文] An Occluded Hooklet of an Embedded Inferior Vena Cava Filter

Yagi Shusuke、Yamamoto Yousuke、Nishiyama Seiichi、Sata Masataka 2018

[雑誌論文] Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study

Izumi Yuishin、Miyamoto Ryosuke、Fujita Koji、Yamamoto Yuki、Yamada Hirotsugu、Matsubara Tomoyasu、Unai Yuki、Tsukamoto Ai、Takamatsu Naoko、Nodera Hiroyuki、Hayashi Shinya、Oda Masaya、Mori Atsuko、Nishida Yoshihiko、Watanabe Shunsuke、Ogawa Hirohisa、Uehara Hisanori、Murayama Shigeo、Sata Masataka、Kaji Ryuji 2018

[雑誌論文] Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A

Maruhashi Tatsuya、Nakashima Ayumu、Goto Chikara、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al. 2018

[雑誌論文] Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice

Sugasawa Noriko、Katagi Ayako、Kurobe Hirotsugu、Nakayama Taisuke、Nishio Chika、Takumi Hiroko、Higashiguchi Fumiharu、Aihara Ken-ichi、Shimabukuro Michio、Sata Masataka、Kitagawa Tetsuya 2018

[雑誌論文] A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure

Saijo Yoshihito、Yamada Hirotsugu、Kusunose Kenya、Bando Mika、Nishio Susumu、Torii Yuta、Hirata Yukina、Seno Hiromitsu、Matsuura Tomomi、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2018

[雑誌論文] Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele

Davy Philip M C、Willcox D Craig、Shimabukuro Michio、Donlon Timothy A、Torigoe Trevor、Suzuki Makoto、Higa Moritake、Masuzaki Hiroaki、Sata Masataka、Chen Randi、Murkofsky Rachel L、Morris Brian J、Lim Eunjung、Allsopp Richard C、Willcox Bradley J 2018

[雑誌論文] Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ―

Maimaituxun Gulinu、Shimabukuro Michio、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Iwase Takashi、Takao Shoichiro、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Sata Masataka 2018

[学会発表] Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers

Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Todoroki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M 2018

[雑誌論文] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E?Deficient Mice

Hara Tomoya、Phuong Pham Tran、Fukuda Daiju、Yamaguchi Koji、Murata Chie、Nishimoto Sachiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Imoto Issei、Shimabukuro Michio、Sata Masataka 2018

[学会発表] Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice

Byambasuren Ganbaatar, Fukuda D, Salim HM, Yagi S, Soeki T, Sata M 2018

[学会発表] Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease

Gulinu Maimaituxun, Shimabukuro M, Fukuda D, Yagi S, Hirata Y, Iwase T, Matsuura T, Ise T , Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M. 2018

[雑誌論文] Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation

Oba Kageyuki、Maeda Minetaka、Maimaituxun Gulinu、Yamaguchi Satoshi、Arasaki Osamu、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Nishio Susumu、Iwase Takashi、Takao Shoichiro、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio 2018

[雑誌論文] Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice

Ganbaatar Byambasuren、Fukuda Daiju、Salim Hotimah Masdan、Nishimoto Sachiko、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Sata Masataka 2018

[学会発表] Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension.

Saijo Y, Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T,Wakatsuki T,Sata M 2018

[学会発表] C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias.

Soeki T, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M 2018

[学会発表] A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography

Kusunose K, Abe T, Haga A, Yamada H, Fukuda D, Harada M, Sata M 2018

[学会発表] Role of epicardial fat in cardiovascular disease

Sata M 2018

[学会発表] Localization of myocardial injury in anthracycline-induced cardiotoxicity: evaluation using two-dimensional speckle tracking echocardiography

Saijo Y, Kusunose K, Bando M, Seno H, Zheng R, Nishio S, Hirata Y, Tori Y, Amano R, Yamada H, Sata M 2018

[雑誌論文] Possible Roles of Epicardial Adipose Tissue in the Pathogenesis of Coronary Atherosclerosis

Tanaka Kimie、Sata Masataka 2018

[雑誌論文] Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure

Kusunose Kenya、Seno Hiromitsu、Yamada Hirotsugu、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2018

[雑誌論文] Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension

Tanaka Atsushi、Tomiyama Hirofumi、Ishizu Tomoko、Higashi Yukihito、Takase Bonpei、Ueda Shinichiro、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Ishibashi Yutaka、Maemura Koji、Ohya Yusuke、Furukawa Taiji、Ito Hiroshi、Yamashina Akira、Node Koichi 2018

[雑誌論文] Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation

Soeki Takeshi、Matsuura Tomomi、Tobiume Takeshi、Bando Sachiko、Matsumoto Kazuhisa、Nagano Hiromi、Uematsu Etsuko、Kusunose Kenya、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Wakatsuki Tetsuzo、Shimabukuro Michio、Sata Masataka 2018

[学会発表] Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling

ham Tran Phuong, Fukuda D, Yagi S, Kusunose K,Yamada H, Soeki T, Shimabukuro M, Sata M 2018

[学会発表] Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice.

Byambasuren Ganbaatar, Fukuda D, Yagi S, Soeki T, Sata M. 2018

[学会発表] Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease

Hirata Y, Kusunose K, Yamada H, Nishio S, Harada O, Miyazato N, Haraguni A, Ito A, Yamaguchi K, Soeki T, Wakatsuki T, Sata M. 2018

[学会発表] Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice

Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M. 2018

[雑誌論文] Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Nishimoto Sachiko、Aini Kunduziayi、Fukuda Daiju、Higashikuni Yasutomi、Tanaka Kimie、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka 2018

[雑誌論文] Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation

Maeda Minetaka、Oba Kageyuki、Yamaguchi Satoshi、Arasaki Osamu、Sata Masataka、Masuzaki Hiroaki、Shimabukuro Michio 2018

[学会発表] Pre-Discharge LV Filling Pressure and Pulmonary Artery Pressure Were Associated With Hospital Readmission in Heart Failure With Reduced and Preserved Ejection Fraction

Torii Y, Kusunose K, Yamada H, Saijo Y, Seno H, Nishio S, Hirata Y, Sata M 2017

[学会発表] Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low Gradient Aortic Stenosis

Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Seno H, Saijo Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M 2017

[学会発表] Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease

Gulinu Maimaituxun, Shimabukuro M, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M 2017

[雑誌論文] Age-related changes in morphology of left atrial appendage in patients with atrial fibrillation

Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Shimizu Rikuto、Torii Yuta、Nishio Susumu、Saijo Yoshihito、Takao Shoichiro、Soeki Takeshi、Sata Masataka 2017

[雑誌論文] RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF

Kusunose Kenya、Yamada Hirotsugu、Nishio Susumu、Ishii Ayumi、Hirata Yukina、Seno Hiromitsu、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka 2017

[学会発表] Direct Slow Pathway Capture: A New Electrophysiological Method of Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia

Matsuura T, Tobiume T, Soeki T, Kato R, Hara M, Takayuki Ise, Kenya Kusunose, Yamaguchi K, Yagi S, Yamada H, Wakatsuki Tetsuzo , Sata M 2017

[学会発表] Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation

Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, Tomoya Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masataka Sata 2017

[学会発表] Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation

Soeki T, Matsuura T, Uematsu E, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M 2017

[学会発表] Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response

Yamaguchi K, Wakatsuki T, Kawabata Y, Ito H, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M 2017

[図書] Mouse models of vascular dieseases

Masataka Sata ed. 2016

[学会発表] Role of innate immunity in chronic inflammation in arterial wall and adipose tissue

Masataka Sata 2016

[学会発表] Effect of Sitagliptin on Left Ventricular Function in Patients With Type 2 Diabetes a Sub Analysis of the PROLOGUE Study

Seno H, Yamada H, Kusunose K, Amano R, Matsushita M, Nanasato M, Murohara T, Kamiya H, Sata M AHA Scientific Sessions 2016, , Novemeber 12-16, 2016 2016

[雑誌論文] Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation

Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Nishimoto S, Yagi S, Yamada H, Soeki T, Wakatsuki T, Taketani Y, Shimabukuro M, Sata M 2016

[学会発表] Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients With Tachycardia-induced Cardiomyopathy

Kusunose K, Yamada H, Saijo Y, Seno H, Hirata Y, Torii Y, Nishio S, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M 2016

[雑誌論文] Glycemic control with ipragliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction in streptozotocin-induced diabetic mouse

Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M 2016