トップ研究者を探す全ゲノムと免疫病理解析に基づく脱髄性疾患のグリアシンシチウム破綻機序の解明と修復

全ゲノムと免疫病理解析に基づく脱髄性疾患のグリアシンシチウム破綻機序の解明と修復

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16H02657
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
内科系臨床医学
神経内科学
研究機関 九州大学
代表研究者 吉良 潤一
研究分担者 松下 拓也
研究分担者 山口 浩雄
研究分担者 山崎 亮
研究分担者 山本 健
研究分担者 篠田 紘司
研究分担者 真崎 勝久
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 47,320,000 (直接経費 :36,400,000、間接経費 :10,920,000)
配分額(履歴) 2018年度:13,650,000 (直接経費 :10,500,000、間接経費 :3,150,000)
2017年度:13,650,000 (直接経費 :10,500,000、間接経費 :3,150,000)
2016年度:20,020,000 (直接経費 :15,400,000、間接経費 :4,620,000)
キーワード 多発性硬化症
GWAS
アストログリア
オリゴデンドログリア
コネキシン
ミクログリア
視神経脊髄炎
グリアシンシチウム
免疫グリア細胞間相互作用
T細胞

研究成果

[学会発表] Focal cortical astrocytopathy with demyelination in neuromyelitis optica spectrum disorder

Shotaro Hayashida, Katsuhisa Masaki, Satoshi O. Suzuki, Takuya Matsushita, Ryo Yamasaki, Toshihiko Suenaga, Kazuya Takahashi, Toru Iwaki, Jun-ichi Kira 2018

[学会発表] T cell receptor repertoire in multiple sclerosis patients

Fumie Hayashi, Noriko Isobe, Yuri Nakamura, Takuya Matsushita, Jun-ichi Kira 2018

[学会発表] 多発性硬化症ではインターフェロンβ治療によるVδ1-Vδ2-Vγ9- γδ型T細胞の増加が良好な予後と関連する

グザリアイ・マイマイテジャン、渡邉充、篠田紘司, 中村優理、真崎勝久、松下拓也、山﨑亮、吉開泰信、吉良潤一 2018

[学会発表] Altered gd T Cell repertoire correlates with disability in untreated Multiple Sclerosis

Guzailiayi Maimaitijiang, Koji Shinoda, Mitsuru Watanabe, Yuri Nakamura, Katsuhisa Masaki, Takuya Matsushita, Ryo Yamasaki, Yasunobu Yoshikai, Jun-ichi Kira 2018

[学会発表] 多発性硬化症患者におけるT細胞受容体レパトアの解析

林 史恵, 磯部 紀子, Guzailiayi Maimaitijiang, 中村 優理, 篠田 紘司, 松下 拓也, 吉良 潤一 2018

[学会発表] Oligodendroglia-specific conditional ablation of connexin 47 is sufficient to produce relapse and progression in demyelinating disease

Yinan Zhao, Ryo Yamasaki, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira 2018

[学会発表] Astroglial connexin (Cx)30 and Cx43 and oligodendroglial Cx47 differentially modulate acute and chronic experimental autoimmune encephalomyelitis

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi 2018

[雑誌論文] Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia

Fang Mei、Yamasaki Ryo、Li Guangrui、Masaki Katsuhisa、Yamaguchi Hiroo、Fujita Atsushi、Isobe Noriko、Kira Jun-ichi 2018

[学会発表] Oligodendroglia-specific connexin47 deletion produces a relapse-remitting multiple sclerosis model

Ryo Yamasaki, Yinan Zhao, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira 2018

[学会発表] A novel secondary progressive multiple sclerosis model by oligodendroglia-specific inducible conditional knockout of connexin 47

Ryo Yamasaki, Yinan Zhao, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira 2018

[学会発表] Deviated Repertoire of γδT Cells is Associated with Disease Severity of Multiple Sclerosis.

Maimaitijiang Guzailiayi, Koji Shinoda, Yuri Nakamura, Takuya Matsushita, Ryo Yamasaki, Yasunobu Yoshikai, Jun-ichi Kira 2017

[学会発表] 視神経脊髄炎脳病巣の神経病理学的検討:大脳皮質の炎症細胞浸潤と脱髄を伴う限局性アストロサイトパチー

林田翔太郎, 眞﨑勝久, 鈴木諭, 松下拓也, 山﨑亮, 末長敏彦, 高橋和也, 岩城徹, 吉良潤一 2017

[学会発表] Focal cortical astrocytopathy lesions with demyelination and inflammatory cell infiltrates in neuromyelitis optica spectrum disorder: a neuropathological study of eleven autopsied cases.

Shotaro Hayashida, Katsuhisa Masaki, Satoshi O. Suzuki, Takuya Matsushita, Ryo Yamasaki, Toshihiko Suenaga, Kazuya Takahashi, Toru Iwaki, Jun-ichi Kira 2017

[学会発表] γδ型T細胞のレパトワ偏倚は多発性硬化症の臨床的障害度に関連する

篠田絋司, グザリアイ・ママティジャン, 中村優理, 眞﨑勝久, 松下拓也, 山﨑亮, 吉開泰信, 吉良潤一 2017

[学会発表] Derangement of γδ T cell subsets is associated with disease severity of multiple sclerosis.

Maimaitijiang Guzailiayi, Koji Shinoda, Yuri Nakamura, Katsuhisa Masaki, Takuya Matsushita, Ryo Yamasaki, Yasunobu Yoshikai, Jun-ichi Kira 2017

[学会発表] A Distinct Repertoire of γδ T cell Population is Associated with Disease Severity of Multiple Sclerosis.

Koji Shinoda, Maimaitijiang Guzailiayi, Yuri Nakamura, Katsuhisa Masaki, Takuya Matsushita, Ryo Yamasaki, Yasunobu Yoshikai, Jun-ichi Kira 2017

[学会発表] 多発性硬化症患者におけるT細胞受容体レパトアの解析

林史恵, 磯部紀子, Guzalliayi Maimatijiang, 中村優理, 篠田紘司, 松下拓也, 吉良潤一 2017

[学会発表] Elucidation of pathophysiology of glial dysfunction in neurological/psychiatric disorders.

Jun-ichi Kira, Mitsuru Watanabe, Ryo Yamasaki, Takuya Matsushita, Hiroo Yamaguchi, Katsuhisa Masaki, Atsushi Fujita, Hayato Une, Mei Fang, Takayuki Fujii, Shintaro Hayashida, Ban-yu Saitoh, Wataru Shiraishi, Yinan Zhao, Ulfa Camelia Indiasari 2017

[学会発表] Oligodendroglia-specific Connexin 47 deletion induced relapse-remitting EAE model mice.

Ryo Yamasaki, Yinan Zhao, Hiroo Yamaguchi, Jun-ichi Kira 2017

[学会発表] Astroglial and Oligodendroglial Connexins Differentially Influence Both Acute and Chronic Progressive Experimental Autoimmune Encephalomyelitis.

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi 2017

[学会発表] Oligodendroglial Cx47 mediates myelin protective effects and plays a role in suppressing infiltration of inflammatory cells in autoimmune encephalomyelitis.

Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Hayato Une, Yiwen Cui, Jun-ichi Kira 2017

[学会発表] Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis.

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi 2017

[学会発表] Experimental autoimmune encephalomyelitis is ameliorated in mice with gray matter astroglia-specific inducible connexin 43 knock-out.

Hayato Une, Hiroo Yamaguchi, Yinan Zhao, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, Ryo Yamasaki, Jun-ichi Kira 2017

[学会発表] Connexin 30 欠損マウスにおける慢性進行期EAEの軽症化

山﨑亮, 方梅, 李広瑞, 藤田篤史, 宇根隼人, 山口浩雄, 吉良潤一 2017

[学会発表] Th1 cells inhibit the expression of connexin 43 in astrocytes via microglial activation

Mitsuru Watanabe, Katsuhisa Masaki, Ryo Yamasaki, Jun Kawanokuchi, Hideyuki Takeuchi, Takuya Matsushita, Akio Suzumura, Jun-ichi Kira 2016

[学会発表] Distinct Repertoires of CD4 and CD8 T Cells in Multiple Sclerosis Patients with and without Deletion-type Copy Number Variations

Guzailiayi Maimaitijiang, Koji Shinoda, Yuri Nakamura, Katsuhisa Masaki, Takuya Matsushita, Ryo Yamasaki, Yasunobu Yoshikai, Jun-ichi Kira 2016

[学会発表] Clinical and immunological analysis of multiple sclerosis with deletion type of copy-number variation

Guzailiayi Maimaitijiang, Koji Shinoda, Yuri Nakamura, Song Zi ye Takuya Matsushita, Ryo Yamasaki, Jun-ichi Kira 2016

[学会発表] Experimental autoimmune encephalomyelitis in mice with induced conditional connexin 43 knock-out (Cx43cKO)

Hayato Une ,Hiroo Yamaguchi, Yinan Zhao,Koji Shinoda,Katsuhisa Masaki, Magdalena Gotz ,Ryo Yamasaki, Jun-ichi Kira 2016

[学会発表] Experimental Autoimmune Encephalomyelitis (EAE) is Ameliorated in Mice with Gray Matter (GM) Astrocyte- Specific Inducible Conditional Connexin 43 Knock-Out (Cx43cKO)

Hayato Une, Hiroo Yamaguchi, Yinan Zhao, Koji Shinoda, Katsuhisa Masaki, Magdalena Gotz, Ryo Yamasaki, and Jun- ichi Kira 2016

[学会発表] Early and Extensive Spinal White Matter Pathologyin Neuromyelitis Optica

Shintaro Hayashi, Ryo Yamasaki, Hiroyuki Murai,Koichi Okamoto, Jun-ichi Kira 2016

[学会発表] Th1 cells inhibit the expression of connexins in astrocytes

Mitsuru Watanabe, Katsuhisa Masaki, Ryo Yamasaki, Jun Kawanokuchi, Hideyuki Takeuchi, Akio Suzumura, Jun-ichi Kira 2016