メモリーTh2細胞によるアレルギー疾患の病態制御に関する研究

トップ›研究者を探す›メモリーTh2細胞によるアレルギー疾患の病態制御に関する研究

代表研究者	山下政克
研究課題番号	KAKENHI-PROJECT-16616003
研究種目	基盤研究(C)
研究分野	アレルギー
研究機関	千葉大学
研究期間開始年月日	2004/4/1
研究期間終了年度	2005
研究ステータス	完了 (2005/4/1)
配分額（合計）	3,700,000 (直接経費 :3,700,000)
配分額（履歴）	2005年度：1,400,000 (直接経費 :1,400,000) 2004年度：2,300,000 (直接経費 :2,300,000)
キーワード	メモリーTh2細胞エフェクターTh2細胞アレルギー性炎症 GATA3 MLL Bmi1 Gfi1 好酸球 IgE Gfi-1 memory Th2 cell effector Th2 cell allergic inflammation GATA3 MLL Bmil

研究成果

[雑誌論文] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses

Yamashita, M. 2006

[雑誌論文] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses

Yamashita, M. 2006

[雑誌論文] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.

Hasegawa, A, Miki, T., Hosokawa, H., Hossain, M.B., Shimizu, C., Hashimoto, K., Kimura, Y.M., Yamashita, M., Nakayama, T. 2006

[雑誌論文] Regulation of allergic airway inflammation through Toll like receptor 4-mediated modification of mast cell function.

Nigo, I.Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T. 2006

[雑誌論文] Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.

Miyamoto, T., Kaneko, T., Yamashita, M., Tenda, Y., Inami, M., Suzuki, A., Ishii, S., Kimura, M., Hashimoto, K., Shimada, H., Yahata, H., Ochiai, T., Saito, I., DeGregori, J., Nakayama, T. 2005

[雑誌論文] Ras-ERK MARK cascade regulates GATA3 stability and Th2 differentiation through ubiqutin-proteasome pathway.

Yamashita, M. 2005

[雑誌論文] Regulation of Th2 cell differentiation by murine Schnurri-2.

Kimura, Y.M., Hosokawa, H., Yamashita, M., Watarai, H., Hasegawa, A., Iwamura, C., Taniguchi, M., Takagi, T., Ishii, S., Nakayama, T. 2005

[雑誌論文] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.

Yamashita, M. 2005

[雑誌論文] Chromatin remodeling of the Th2 cytokine gene loci.

Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., Shinnakasu, R. 2005

[雑誌論文] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.

Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., Nakayama, T. 2005

[雑誌論文] Essential role of GATA3 for the maintenance Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.

Yamashita, M. 2004

[雑誌論文] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.

Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., Nakayama, T. 2004

[雑誌論文] CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells.

Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., Nakayama, T. 2004

[雑誌論文] Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.

Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., Nakayama, T. 2004

[雑誌論文] Essential role of GATA3 for the maintenance of Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci.

Yamashita, M. 2004

[雑誌論文] STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.

Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M., Nakayama, T. 2004

[雑誌論文] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.

Yamashita, M. 2004

[雑誌論文] Interleukin(IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.

Yamashita, M. 2004

[雑誌論文] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y.M., Hasegawa, A., Nakayama, T.