トップ研究者を探す非CpG-island領域シトシンメテル化による癌細胞多様性制御機構の解析

非CpG-island領域シトシンメテル化による癌細胞多様性制御機構の解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16590278
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
人体病理学
研究機関 神戸大学
代表研究者 北澤 荘平
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額(合計) 3,400,000 (直接経費 :3,400,000)
配分額(履歴) 2006年度:900,000 (直接経費 :900,000)
2005年度:900,000 (直接経費 :900,000)
2004年度:1,600,000 (直接経費 :1,600,000)
キーワード 非CpG-island
メテル化
遺伝子プロモータ
膀胱癌
BAMBI
転写制御
膵癌
TrkA
メチル化
Desmoid tumor
神経周囲浸潤
Non CpG-island
Methylation
Gene promoter
Bladder cancer
BAMBI
Gene transcription
Pancreatic cancer
TrkA

研究成果

[図書] Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research. In ; DNA Methylation Research

Kitazawa S, et al. 2007

[雑誌論文] Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice : a possible role of oxidative stress.

Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M. 2007

[雑誌論文] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis

Kitazawa R, et al. 2007

[図書] Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research.In; DNA Methylation Research

Kitazawa S, et al. 2007

[雑誌論文] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell-and tissue-specific RANKL expression and osteoclastogenesis.

Kitazawa R, Kitazawa S. 2007

[雑誌論文] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency.

Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imamura M, Nishizawa H, Takahashi M, Seo Y, Hayashi Y, Kondo T, Okimura Y, Kaji H, Kitazawa R, Kitazawa S, Chihara K. 2007

[雑誌論文] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis

Kitazawa R, et al. 2007

[雑誌論文] Protruding disordered loop of gClqR is specifically exposed and related to antiapoptotic property in germ cell lineage

Kitazawa S, Takenaka A, Kondo T, Mizoguchi A, Kitazawa R. 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level.

Kitazawa S. et al. 2006

[雑誌論文] Expression and functional analysis of menin in a multiple endocrine neoplasia type I (MENI) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 Gene.

Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K 2006

[雑誌論文] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.

Mori K, Kitazawa R, Kondo T, Yamaguchi A, Maeda S, Kitazawa S 2006

[雑誌論文] Expression profiles of genes related to osteoclastogenesis in mouse growth plate and articular cartilage.

Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S 2006

[雑誌論文] Lung carcinosarcoma with liposarcoma element. an autopsy case.

Kitazawa R, Kitazawa S, Nishimura Y, Kondo T, Obayashi C 2006

[雑誌論文] A case of uterine adenosarcoma presenting as endocerviacal polyp.

Kondo T, Kitazawa R, Yamasaki M, Kitazawa S. 2006

[雑誌論文] Transcriptional regulation of RANKL and OPG.

Kitazawa S, Kitazawa R, Mori K, Kondo T. 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level.

Kitazawa S, et al. 2006

[雑誌論文] A case of alpha-fetoprotein-producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman.

Takeuchi K, Kitazawa S, Hamanishi S, Inagaki M, Murata K. 2006

[雑誌論文] Fetal hydrops associated with spontaneous premature closure of ductus arteriosus.

Kondo T, Kitazawa R, Noda-Maeda N, Kitazawa S. 2006

[雑誌論文] Invasive adenocarcinoma arising from adenomyosis in a septate uterus.

Takeuchi K, Tateiwa H, Hamana S, Yoshida S, Kitazawa S, Maruo T. 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level

Kitazawa S, Kitazawa R 2006

[雑誌論文] Lung carcinosarcoma with liposarcoma element. an autopsy case.

Kitazawa R, et al. 2006

[雑誌論文] Case of virilizing rrenner tumor in a postmenopausal woman with stromal androgenic activity.

Takeuchi K, Kitazawa S, Wakahashi S, Sugimoto M, Morizane M, Maruo T. 2006

[雑誌論文] Uterine bizarre epithelioid lipoleiomyoma with a myxoid stroma.

Takeuchi K, Kitazawa S, Tsujino T, Wakahashi S, Maruo T. 2006

[雑誌論文] DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.

Peng DF, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S, Hirohashi S. 2006

[雑誌論文] Non-structural protein 4A of hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis.

Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H. 2006

[雑誌論文] Protruding disordered loop of gClqR is specifically exposed and related to antiapoptotic property in germ cell lineage.

Kitazawa S, et al. 2006

[雑誌論文] A case of schizophrenia with spinal aspergillosis and tabs dorsalis.

Kondo T, Kitazawa R, Miyake M, Kitazawa S. 2006

[雑誌論文] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Kasga M. 2006

[雑誌論文] Hepatitis C virus NS3 protein interacts with ELKS-{delta} and ELKS-{alpha}, members of a novel protein family involved in intracellular transport and secretory pathways.

Hidajat R, Nagano-Fujii M, Deng L, Tanaka M, Takigawa Y, Kitazawa S, Hotta H. 2005

[雑誌論文] An autopsy case of ulcerative colitis associated with pulmonary thrombus.

Fujimoto M, Kitazawa R, Hirata K, Yamada H, Kondo T, Maeda S, Kitazawa S. 2005

[雑誌論文] T-138C polymorphism of matrix gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification.

Kobayashi N, Kitazawa R, Maeda S, Schurgers LJ, Kitazawa S. 2005

[雑誌論文] Application Trials of in situ Hybridization at Electron Microscopic Level.

Kitazawa S 2005

[雑誌論文] Application trials of in situ hybridization at electron microscopic level.

Kitazawa S, Kondo T, Kitazawa R. 2005

[雑誌論文] Ray tracing analysis of overlapping objects in refraction contrast imaging.

Hirano M, Yamasaki K, Okada H, Sakurai T, Kondoh T, Karafuchi T, Sugimura K, Kitazawa S Kitazawa R, Maeda S, Tamura S. 2005

[雑誌論文] A case of ochronosis presenting acute destructive arthropathy

Kondo T, Kitazawa R, Hasegawa Y, Kitazawa S. 2005

[雑誌論文] A case of postirradiation vaginal angiosarcoma treated with recombinant interleukin-2 therapy.

Takeuchi K, Deguchi M, Hamana S, Motoyama S, Kitazawa S, Maruo T. 2005

[雑誌論文] A case of MEN type I and menin in parathyroid lesions.

Tobimatsu T, Kaji H, Naito J, Yo M, Sowa H, Yamauchi M, Tsukada T, Kitazawa R, Kitazawa S, Sugimoto T, Chihara K. 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : involvement of BAMBI promoter hypermethylation in metaplastic bone formation.

Kitazawa S.Kitazawa R, Obayashi C, Yamamoto T. 2005

[雑誌論文] Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression.

Fujimoto M, Kitazawa R, Maeda S, Kitazawa S. 2005

[雑誌論文] A sister case of type I Pene-Shokeir syndrome

Hekagawa T, Oyasato Y, Koutera A, Katayama Y, Morisawa T, Yokoyama N, Kitazawa S, Matsuo M. 2005

[雑誌論文] Transcriptional regulation mechanism of BMP genes

Kitazawa S.Kitazawa R 2005

[雑誌論文] In situ hybridization on calcified tissue : detection of RANKL mRNA in mouse osteolytic bone lesions

Kitazawa R. et al. 2005

[雑誌論文] Coexistence of brenner tumor and struma ovarii : case report.

Takeuchi K, Ohbayashi C, Kitazawa S, Ohara N, Maruo T. 2005

[雑誌論文] An autopsy case of type I Pene-Shokeir syndrome.

Mori K, Kitazawa R, Kondo T, Kishimoto K, Maeda S, Kitazawa S. 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : possible involvement of BAMBI promoter hypermethylation in metaplastic bone formation

Kitazawa S.et al. 2005

[雑誌論文] Adenofibrosarcoma originating from a mural nodule of ovarian serous cystadenoma.

Takeuchi K, Kitazawa S, Deguchi M, Maruo T. 2005

[雑誌論文] Estimation of Contrast of Refraction Contrast Imaging Compared with Absorption Imaging -Basic Approach.

Hirano M, Yamasaki K, Okada H, Kitazawa S, Kitazawa R, Ohno Y, Sakurai T, Kondoh T, Ohbayashi C, Katafuchi T, Maeda S, Sugimura K, Tamura S. 2005

[雑誌論文] In situ hybridization on calcified tissue : Detection of RANKL mRNA in osteolytic bone lesion.

Kitazawa R, Kitazawa S. 2005

[雑誌論文] Application trials of in situ hybridization at electron microscopic level.

Kitazawa S. et al. 2005

[雑誌論文] In situ Hybridization on Calcified Tissue : Detection of RANKL mRNA in Mouse Osteolytic Lesions.

Kitazawa R 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : involvement of BAMBI promoter hypermethylation in metaplastic bone formation.

Kitazawa S, at al. 2005

[雑誌論文] Consumptive coagulopathy that developed in a pregnant woman with degenerated uterine leiomyoma : case Report.

Kitao K, Ohara N, Funakoshi T, Moriyama T, Morita H, Kitazawa S, Maruo T. 2005

[雑誌論文] Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate.

Kitao K, Ohara N, Funakoshi T, Moriyama T, Maruo T, Yamane M, Yokoyama N, Kondo T, Kitazawa S. 2004

[雑誌論文] la,25 dihydoxyvitamin D3 rapidly regulates the mouse osteoprotegerin through dual pathway.

Kondo T, Kitazawa R, Maeda S, Kitazawa S. 2004

[雑誌論文] A case of giant cell fibroblastome of nose.

Kondo T, Kitazawa S, Kitazawa R, Taguchi K. 2004

[雑誌論文] Transcriptional regulation of a BMP-6 promoter by estrogen receptor alpha.

Ong DB, Colley SM, Norman MR, Kitazawa S, Tobias J. 2004

[雑誌論文] Gene expression in osteolytic lesion of cancer metastasis.

Kitazawa R, Kitazawa S. 2004

[雑誌論文] Transcription factor.

Kitazawa S, Kitazawa R. 2004

[雑誌論文] Imaging of fine structure of bone sample with high coherence X-ray beam and high spatial resolution detector.

Hirano M, Yamasaki K, Kitazawa R, Kitazawa S, Okada H, Katafuchi T, Maeda S, Sakurai T, Kondoh T, Obayashi C, Sugimura K, Tamura S. 2004

[雑誌論文] In vitro real-time imaging of TGFbeta-induced transcriptional activation of the RANK ligand gene in intraosseous prostate cancer.

Zhang J, Lu Y, Dai J, Yao Z, Kitazawa R, Kitazawa S, Zhao X, Hall DE, Pienta KJ, Keller ET. 2004

[図書] 組織細胞化学2004

北澤 荘平 2004

[雑誌論文] Application of ISH to research of regenerative medicine.

Kitazawa S, Kitazawa R. 2004

[雑誌論文] Menin inactivation leads to loss of TGF-b inhibition of parathyroid cell proliferation and PTH secretion

Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, CanaffL, Hendy JN, Sugimoto T, Chihara K. 2004

[雑誌論文] Unsuspected uterine leiomyosarcoma : MR imaging findings before and after focused ultrasound surgery (FUS).

Fukunishi H, Funaki K, Ikuma K, Sugimura K, Kitazawa R, Kitazawa S.

[雑誌論文] Overexpression of thioredoxin 1 in transgenic mice suppresses development of diabetic nephropathy.

Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M.