トップ研究者を探す神経組織における血小板由来増殖因子機能の解明

神経組織における血小板由来増殖因子機能の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16390114
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
基礎医学
実験病理学
研究機関 富山大学
富山医科薬科大学
代表研究者 笹原 正清
研究分担者 藤森 俊彦
研究分担者 尾矢 剛志
研究分担者 石井 陽子
研究分担者 堀 悦郎
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 15,310,000 (直接経費 :14,800,000、間接経費 :510,000)
配分額(履歴) 2007年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
2006年度:2,900,000 (直接経費 :2,900,000)
2005年度:4,100,000 (直接経費 :4,100,000)
2004年度:6,100,000 (直接経費 :6,100,000)
キーワード PDGF
Conditional knockout
Cre lox P

行動実験
神経保護因子
受容体
神経分化
conditional knockout
Crelox P
血小板由来増殖因子
knockout
conditional
線維芽細胞
Akt
MAP kinase
PDGF
Conditional knockout
Cre
loxP
Brain
Behavior analyses
Neurotrophic factor
Receptor
Neuronal differentiation

研究成果

[雑誌論文] PDGF Receptor β is a Potent Regulator of Mesenchymal Stromal Cell Function

Tokunaga, A. Oya T., Ishii Y., Motomura H., Nakamura C., Ishizawa S., Fujimori T., Nabeshima, Y., Umezawa, A. Kanamori, M., Kimura, T., Sasahara, M 2008

[学会発表] Transgenic PAF-Acetylhydrolase II Protects Neurons in Mouse Models of Transient Focal Cerebral Ischemia.

Kato, I., Umemura, K., Ishii, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Arai, H., Hayashi, N., Hamada, H., Endo, S., Hirashima, Y., Hiraga, K 2007

[学会発表] Neuroprotection by PAF-acetylhydrolase II in transgenic mouse models of transient focal cerebral ischemia

Kato, I., Umemura, K, Ishu, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Arai, H., Hayashi, N., Hamada, H., Endo, S., Hirashima, Y., Hiraga, K 2007

[学会発表] The role of PDGF-β in the Activation of mouse stellate cells

Morita, S., Oya, T., Ishu, Y., Sabit, H., Tokunaga, A. Ishizawa, S., Matsushima, T., Kurashige, Y., Sasahara, M 2007

[学会発表] The analysis of the function of PDGF- β in fibroblast migration

Tokunaga, A. Oya, T., Ishii, Y., Sabit, H., Matsushima, T., Kurashige, Y., Ishizawa, S., Kanamori, M., Sasahara, M 2007

[雑誌論文] A functional polymorphism in COL11A1, encoding the alphal chain of type XI collagen, is associated with susceptibility to lumbar disc herniation

Mio, F., Chiba, K, Hirose, Y., Kawaguchi, Y., Mikami, Y., Oya, T., Mori, M., Kamata, M., Matsumoto, M., Ozaki, K, Tanaka, T., Takahashi, A. Kubo, T., Kimura, T., Toyama, Y., Ikegawa, S 2007

[学会発表] PDGF- 3 protects neuron from oxidative stress via the P13K/Akt signal.

Zheng, L., Ishu, Y., Oya, T., Sabit, H., Matsushima, T., Kurashige, Y., Ishizawa, S., Sasahara, M 2007

[学会発表] Neuroprotection of PDGF-B against oxidative stress via the PI3K/Akt signal

Zheng, L., Ishii, Y., Oya, T., Tokunaga, A. Hamashima, T., Ishizawa, S. Sasahara, M 2007

[雑誌論文] Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia

Umemura, K., Kato, I., Hirashima, Y., Ishii, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Hayashi, N., Hamada, H., Endo, S., Oda, M., Arai, H., Kinouchi, H., Hiraga, K 2007

[学会発表] CaMKII alpha-transgenic Mice Shows Pathological Changes of Diabetic Nephropathy with Enhanced Expression of PDGF-B Chain and PDGF-beta Receptor.

Suzuki, H., Oya, T., Usui, I., Kato, I., Yamazaki, Y., Fujisaka, S., Bukhari, A. Asamizu, S., Kanatani, Y., Ihiki, M., Urakaze, M., Takasawa, S., Okamoto, H., Sasahara, M., Kobayashi, M 2007

[雑誌論文] Impaired regulation of gonadotropins leads to the atrophy of female reproductive system in klotho deficient mice

Toyama, R., Fujimori, T., Nabeshima, Y., Itoh, Y., Tsuji, Y., Osamura, R.Y.,Nabeshima, Y 2006

[学会発表] The role of platelet-derived growth factor receptor 8 in the process of mouse hepatic stellate cell activation.

Morita, S., Sabit, H., Oya, T., Tokunaga, A. Kudo, H., Yata, Y., Takahara, T., Ishu, Y., Ishizawa, S., Tsukada, K., Sasahara, M 2006

[雑誌論文] Therapeutic Potential of(-)-Epigallocatechin 3-O-gallate on Renal Damage in Diabetic Nephropathy Model Rats

Yamabe, N., Yokozawa, T., Oya, T., Kim, M 2006

[雑誌論文] Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury

Ishii, Y., Oya, T., Zheng, L., Gao, Z., Kawaguchi, M., Sabit, H., Matsushima, T., Tokunaga, A. Ishizawa, S., Hori, E., Nabeshima, Y., Sasaoka, T., Fujimori, T., Mori, H., Sasahara, M 2006

[学会発表] The analysis of PDGF receptor and its signaling in peripheral nervous regeneration

Yamazaki, T., Oya, T., Sabit, H., Ishu, Y., Ishizawa, S., Sasahara, M 2006

[学会発表] Giant Sertoli-stromal cell tumor with rhabdomyoblastic element of the ovary

Nakagawa, K., Kiya, C., Moriya, S., Murosaka, C., Nakamura, T., Sakai, Y., Tanaka, T., Ejiri, S., Oya, T., Fukuoa, J 2006

[学会発表] A novel model for diabetic retinopathy

Ichsan, A.M., Kato, I., Oya, T., Tomi, M., Takasawa, S., Okamoto, H., Sasahara, M., Hayasaka, S., Hosoya, K., Hiraga K 2006

[学会発表] Mouse brains deficient in neuronal PDGF receptor-13 develop normally but are vulnerable to injury

Ishii, Y., Oya, T., Zheng, L., Sasahara, M 2006

[学会発表] Malignant solitary fibrous tumor in pelvic cavity. Report of a case

Kawamura, S., Kiya, C., Oya, T., Sakai, Y., Nakagawa, K., Ejiri, S., Fukuoka, J 2006

[学会発表] Expression of constitutively active form of CaM kinase II in pancreatic beta cells of transgenic mice leads to severe diabetes mellitus.

Kato, I., Hiraga, K, Oya, T., Sasahara, M., Takasaki, I., Tabuchi, Y., Takasawa, S., Okamoto, H 2006

[学会発表] Overexpression of PAF-acetylhydrolase II in transgenic mouse brain supresses ischemic stress-induced neuronal cell death

Umemura, K., Kato, I., Hirashima, Y., Ishii, Y., Oya, T., Hayashi, N., Hamada, H., Inoue, T., Aoki, J., Kinouchi, H., Hiraga, K., Endo, S 2006

[学会発表] Activation of PDGF receptor and downstream signals in regenerating peripheral nerve

Sabit, H., Yamazaki, T., Oya, T., Ishii, Y., Furuta, I., Sasahara, M 2006

[雑誌論文] Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism

Cheng, C., Tsuneyama, K, Zheng, H., Oya, T., Cui, Z., Feril, L.B., Jr., Takano, Y 2006

[雑誌論文] Impaired regulation of gonadotropins leads to the atrophy of female reproductive system in klotho deficient mice.

Toyama R. 2006

[学会発表] Expression of constitutively active form of CaM kinase II in pancreatic beta cells of transgenic mice leads to severe diabetes mellitus

Kato, I., Hiraga, K., Oya, T., Sasahara, M., Takasaki, I., Tabuchi, Y., Takasawa, S., Okamoto, H 2005

[学会発表] Establishment of mutant mouse with neuron-specific PDGF receptor depletion

Sasahara, M., Gao, Z., Oya, T., Ishii, Y., Sasaoka, T., Ishizawa, S., Matsushima, T., Kurashige, Y., Sabit, H., Zheng, L., Tokunaga, A. Fujimori, T 2005

[学会発表] The activation of ERK1/2 and JNK, but not p38, was attenuated after PDGFR- Q depletion

Gao, Z., Sasahara, M., Sasaoka, T., Oya, T., Ishu, Y., Sabit, H., Ishizawa, S 2005

[雑誌論文] Green tea polyphenol and dietary fiber protect against kidney damage in rats with diabetic nephropathy

Yokozawa, T., Nakagawa, T., Oya T., Okubo, T., Juneja, L.R 2005

[学会発表] Systematic analyses Of retinas of transgenic mice overexpressing constitutively active form of CaM kinase II

Ichsan, A.M., Kato, I., Oya, T., Sasahara, M., Takasawa, S., Okamoto, H., Hayasaka, S., Takasawa, K., Hiraga, K 2005

[学会発表] A study on proliferation, migration and apoptosis after PDGF- β knockout in dermal fibroblasts

Sasahara, M., Gao, Z., Sasaoka, T., Oya, T., Ishu, Y., Sabit, H., Ishizawa, S 2005

[学会発表] Cre-loxPノックアウトシステムを用いた皮膚線維芽細胞におけるPDGFR-β機能の解析.

尾矢剛志 2005

[雑誌論文] ZFH4 protein is expressed in many neurons of developing rat brain

Nogami, S., Ishii, Y., Kawaguchi, M., Sakata, N., Oya, T., Takagawa, K., Kanamori, M., Sabit, H., Obata, T., Kimura, T., Sasahara, M 2005

[雑誌論文] A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease

Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S 2005

[学会発表] The analysis of the PDGF- p function in fibroblasts using Cre-loxP knockout system

Oya, T., Gao, Z., Ishu, Y., Sasaoka, T., Sabit, H., Tokunaga, A. Zheng, L., Ishizawa, S., Fujimori, T., Sasahara, M 2005

[雑誌論文] Spinal stenosis due to the ossified lesions of the lumbar spine

Kawaguchi, Y., Oya, T., Abe, Y., Kanamori, M., Ishihara, H., Yasuda, T., Nogami, S., Hori, T., Kimura, T 2005

[雑誌論文] Deletion of The PDGFR-B gene affects key fibroblast functions important for wound healing.

Gao, Z., Sasaoka, T., Fujimori, T., Oya, T., Ishii, Y., Sabit, H., Kawaguchi, M., Kurotaki, Y., Naito, M., Wada, T., Ishizawa, S., Kobayashi, M., Nabeshima, Y., Sasahara, M 2005

[雑誌論文] Some biochemical and histochemical properties of human liver serine dehydratase

Kashii, T., Gomi, T., Oya, T., Ishii, Y., Oda, H., Maruyama, M., Kobayashi, M., Masuda, T., Yamazaki, M., Nagata, T., Tsukada, K., Nakajima, A. Tatsu, K., Mori, H., Takusagawa, F., Ogawa, H., Pitot, H.C 2005

[学会発表] Expression analysis of ATBF1 and ZFH4, the zinc-finger and homeodomain family proteins(ZFH family proteins), in developing rat brains

Ishii, Y., Nogami, S., Kawaguchi, M., Oya, T., Sasahara, M 2004

[雑誌論文] Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neural death after transient forebrain ischemia in gerbil

Yokoyama, K., Shimada, Y., Hori, E., Sekiya, N., Goto, H., Sakakibara, I., Nishijo, H., Terasawa, K 2004

[雑誌論文] Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neural death after transient forebrain ischemia in gerbil.

Yokoyama K. 2004

[雑誌論文] Effects of Choto-san and hooks and stem of Uncaria sinensis on a antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia

Yokoyama, K, Shimada, Y, Hori, E, Nakagawa, T, Takagi, S, Sekiya, N, Kohta, K, Nishijo, H, Yokozawa, T, Terasawa, K 2004

[学会発表] Akt activation is attenuated after PDGFR- β knockout in fibroblast cells

Gao, Z., Ishii, Y., Oya, T., Takagawa, K., Kawaguchi, M., Sasaoka, T., Naito, M., Kobayashi, M., Sasahara, M 2004

[雑誌論文] Effects of Choto-san and hooks and stem of Uncaria sinensis on a antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia.

Yokoyama K. 2004