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尾矢剛志

徳島大学

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2024年4月25日更新

職名: 准教授
電話: 研究者総覧に該当データはありませんでした。
電子メール: oya.takeshi@tokushima-u.ac.jp
学歴: 1996/3: 富山医科薬科大学医学部医学科卒業
2001/9: 富山医科薬科大学大学院医学系研究科博士課程修了
学位: 博士(医学) (富山医科薬科大学) (2001年9月)
職歴・経歴: 2018/4: 徳島大学特任助教, 病院 (-2018.6.)
2018/7: 徳島大学助教, 大学院医歯薬学研究部 (-2019.12.)
2020/1: 徳島大学准教授, 大学院医歯薬学研究部

専門分野・研究分野: 人体病理学 (Pathology)

研究者総覧で最新データを確認する

2024年4月25日更新

専門分野・研究分野: 人体病理学 (Pathology)
担当経験のある授業科目: ヒューマンサイエンス(病理病態学) (大学院)
病理学(Ⅰ・Ⅱ) (学部)
病理学Ⅰ・病理学Ⅰ実習 (学部)
病理学Ⅱ・病理学Ⅱ実習 (学部)
病理学実習 (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年4月25日更新

専門分野・研究分野: 人体病理学 (Pathology)

研究テーマ: 研究者総覧に該当データはありませんでした。

著書

常山幸一, 尾矢剛志 :
腫瘍病理鑑別診断アトラス肝癌第2版悪性リンパ腫および偽リンパ腫,
文光堂, 東京, 2020年11月. 常山幸一, 尾矢剛志 :

文光堂, 2020年11月. 尾矢剛志 :
腎疾患の病理アトラス尿細管間質疾患と血管疾患のWHO分類第10章重金属による尿細管間質性腎症. (ISBN4-88563-159-9: 訳Renal Disease. Classification and Atlas of Tubulo-Interstitial and Vascular Diseases. Seshan SV et al.),
株式会社東京医学社, 2005年10月.

論文

Wenhua Shao, Mayuko Ichimura-Shimizu, Hirohisa Ogawa, Shengjian Jin, Mitsuko Sutoh, Satoko Nakamura, Miki Onodera, Hirosuke Tawara, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya and Koichi Tsuneyama :
Establishment of repeated liver biopsy technique in experimental mice.,
Heliyon, Vol.9, No.6, e16978, 2023.

(要約): Biopsy is a commonly used method for determining pathological diagnoses by directly using human tissues and cells. Biopsies are widely used to determine disease progression and treatment efficacy. Although organs and tissues are usually obtained by sacrifice during animal experiments, it is theoretically possible to use the same biopsy techniques in humans. In the present study, we examined the feasibility of performing four repeated liver biopsies in a spontaneous metabolic syndrome mouse model. Even though a small number of mice died accidently, most mice were able to undergo four liver biopsies without significant adverse events. We also performed three liver biopsies in mouse liver tumor carcinogen models at 4, 8, and 12 weeks of age. In addition to the sample collected at 16 weeks of age during sacrifice, we successfully collected four liver samples from the same mice at different stages of disease progression. The application of this liver biopsy technique might make it possible for direct evaluation of pathological conditions in the same individual over time, thereby reducing the number of experimental animals.
(徳島大学機関リポジトリ): ● Metadata: 118954
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.heliyon.2023.e16978
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37484353; ● Search Scopus @ Elsevier (PMID): 37484353; ● Search Scopus @ Elsevier (DOI): 10.1016/j.heliyon.2023.e16978

(徳島大学機関リポジトリ: 118954, DOI: 10.1016/j.heliyon.2023.e16978, PubMed: 37484353) Minoru Matsumoto, 吉田英行, Koichi Tsuneyama, Takeshi Oya and Mitsuru Matsumoto :
Revisiting Aire and tissue-restricted antigens at single-cell resolution,
Frontiers in Immunology, Vol.14, 1176450, 2023. Junko Morimoto, Minoru Matsumoto, Takeshi Oya, Koichi Tsuneyama and Mitsuru Matsumoto :
Cooperative but Distinct Role of Medullary Thymic Epithelial Cells and Dendritic Cells in the Production of Regulatory T Cells in the Thymus.,
The Journal of Immunology, 2023.

(要約): Regulatory T cells (Tregs) are produced in the thymus to establish self-tolerance, and agonistic stimuli by self-Ags play a pivotal role in this process. Although two types of APCs, medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), are responsible for presenting self-Ags together with costimulatory/cytokine signals, the distinct role of each APC in producing Tregs remains enigmatic. We have approached this issue by depleting the mTECs and DCs using mice expressing diphtheria toxin receptors driven by Aire and CD11c promoters, respectively. Depletion of mTECs showed an effect on Treg production quantitatively and qualitatively more profound than that of DCs followed by the development of distinct organ-specific autoimmune lesions in the hosts. Because self-Ags produced by mTECs are transferable to DCs through a process known as Ag transfer, we monitored the process of Ag transfer using mice expressing GFP from TECs. Although GFP expressed from total TECs was effectively transferred to DCs, GFP expressed from cortical TECs was not, suggesting that mTECs are the predominant source of self-Ags. We also found that GFP expressed not only from mature mTECs but also from immature mTECs was transferred to DCs, suggesting that a broad spectrum of molecules were subjected to Ag transfer during mTEC development. Interestingly, the numbers of recirculating non-Tregs producing IL-2, an important source for Treg expansion in the thymus, were reduced only in the mTEC-depleted mice. These results suggested the cooperative but distinct role of mTECs and DCs in the production of Tregs to avoid autoimmunity.
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/jimmunol.2200780
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37067332; ● Search Scopus @ Elsevier (PMID): 37067332; ● Search Scopus @ Elsevier (DOI): 10.4049/jimmunol.2200780

(DOI: 10.4049/jimmunol.2200780, PubMed: 37067332) Minoru Matsumoto, Takuya Ohmura, Yuto Hanibuchi, Mayuko Shimizu, Yasuyo Saijo, Hirohisa Ogawa, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto and Takeshi Oya :
AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma.,
Cancer Medicine, 2023.

(要約): Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC-specific transcriptional regulator that is required for immunological self-tolerance. We found that a large proportion of TCs expressed AIRE with typical nuclear dot morphology by immunohistochemistry. AIRE expression in TCs was supported by the RNA-seq data in the TCGA-THYM database. Furthermore, our bioinformatics approach to the recent single-cell RNA-seq data on human thymi has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations. In contrast, TCs lacked the gene signatures for cTECs. We propose that TCs are tumors derived from mTECs.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.5777
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36912123; ● Search Scopus @ Elsevier (PMID): 36912123; ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.5777

(DOI: 10.1002/cam4.5777, PubMed: 36912123) Makoto Takeuchi, Toshihiko Nishisho, Shun-ichi Toki, Shinji Kawaguchi, Shunsuke Tamaki, Takeshi Oya, Yoshihiro Uto, Toyomasa Katagiri and Koichi Sairyo :
Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondrial dysfunction in synovial sarcoma.,
Cancer Medicine, Vol.12, No.8, 9668-9683, 2023.

(要約): Taken together, our results revealed that BL induced apoptosis via the ROS-mitochondrial signaling pathway, and autophagy was activated in response to the production of ROS, which protected SS cells from apoptosis. Therefore, BL is a promising candidate for the development of an antitumor therapeutic strategy targeting SS.
(キーワード): Humans / Mice / Animals / Reactive Oxygen Species / Sarcoma, Synovial / Apoptosis / Autophagy / Mitochondria / Cell Line, Tumor
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.5664
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36722116; ● Search Scopus @ Elsevier (PMID): 36722116; ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.5664

(DOI: 10.1002/cam4.5664, PubMed: 36722116) Ryuichiro Miyazawa, Jun-Ichi Nagao, Ken-Ichi Arita-Morioka, Minoru Matsumoto, Junko Morimoto, Yoshida Masaki, Takeshi Oya, Koichi Tsuneyama, Hedeyuki Yoshida, Yoshihiko Tanaka and Mitsuru Matsumoto :
Dispensable Role of Aire in CD11c+ Conventional Dendritic Cells for Antigen Presentation and Shaping the Transcriptome.,
ImmunoHorizons, Vol.7, No.1, 140-158, 2023.

(要約): Aire, the defect of which is responsible for the development of autoimmunity, is predominantly expressed in medullary thymic epithelial cells, and it controls a wide variety of genes, including those of tissue-restricted Ags, for establishing thymic tolerance. Aire is also expressed from APCs in the periphery, called extrathymic Aire-expressing cells (eTACs), and their complementing role to thymic tolerance has been suggested. eTACs are composed of two distinct classes of APCs, conventional dendritic cell (cDC)-type and group 3 innate lymphoid cell (ILC3)-like-type expressing retinoic acid receptor-related orphan receptor γt (RORγt). Although the essential role of Aire in the latter in the Th17-mediated immune response against Candida albicans has been reported, the role of Aire in the cDC-type eTACs for this action has not been examined. Furthermore, the significance of Aire in the production of the transcriptome of the cDC-type eTACs remains unknown. We have approached these issues using a high-fidelity Aire-reporter mouse strain. We found that although the cDC-type eTACs dominated ILC3-like-type eTACs in number and they served as efficient APCs for the immune response against an exogenous Ag as well as for the C. albicans-specific Th17 immune response, loss of Aire in cDC-type eTACs showed no clear effect on these functions. Furthermore, loss of Aire showed no major impact on the transcriptome from cDC-type eTACs. These results suggested that Aire in cDC-type eTACs may not have a cell-intrinsic role in the immune response in contrast to the role of Aire in ILC3-like-type eTACs.
(徳島大学機関リポジトリ): ● Metadata: 118793
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/immunohorizons.2200103
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4049/immunohorizons.2200103

(徳島大学機関リポジトリ: 118793, DOI: 10.4049/immunohorizons.2200103) Satoshi Sumida, Mayuko Shimizu, Yuko Miyakami, Takumi Kakimoto, Tomoko Kobayashi, Yasuyo Saijo, Minoru Matsumoto, Hirohisa Ogawa, Takeshi Oya, Yoshimi Bando, Hisanori Uehara, Shu Taira, Mitsuo Shimada and Koichi Tsuneyama :
Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 251-259, 2023.

(要約): Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin. J. Med. Invest. 70 : 251-259, February, 2023.
(キーワード): Humans / Epidermal Cyst / Spleen / Pancreatic Diseases / Epithelial Cells / Immunohistochemistry
(徳島大学機関リポジトリ): ● Metadata: 118205
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.251
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164730; ● Search Scopus @ Elsevier (PMID): 37164730; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.251

(徳島大学機関リポジトリ: 118205, DOI: 10.2152/jmi.70.251, PubMed: 37164730) Shoko Yamashita, Chie Takasu, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Hiroki Mori, Shinichiro Yamada, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada :
Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation.,
Journal of Hepato-Biliary-Pancreatic Sciences, Vol.30, No.4, 462-472, 2022.

(要約): Compared with the control and cholecystitis groups, αSMA expression was higher in the cancerous part (stroma) of the GB in patients with GB cancer + PBM and in the lamina propria of patients with PBM. The CD204/CD68 ratio in the lamina propria was higher in the PBM group than in the control and cholecystitis groups. NLRP3 and caspase 1 expression in both the lamina propria and epithelium was higher in the PBM than control group. In the PBM group, NLRP3- and caspase 1-positive cells in the lamina propria were located near the epithelium.
(キーワード): Humans / Inflammasomes / Bile Ducts / Caspase 1 / NLR Family, Pyrin Domain-Containing 3 Protein / Pancreaticobiliary Maljunction / Pancreatic Ducts / Biliary Tract Neoplasms / Gallbladder Neoplasms / Cholecystitis / Carcinogenesis
(徳島大学機関リポジトリ): ● Metadata: 119056
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/jhbp.1253
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36259178; ● Search Scopus @ Elsevier (PMID): 36259178; ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.1253

(徳島大学機関リポジトリ: 119056, DOI: 10.1002/jhbp.1253, PubMed: 36259178) Wenhua Shao, Orgil Jargalsaikhan, Mayuko Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya and Koichi Tsuneyama :
Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice.,
International Journal of Molecular Sciences, Vol.23, No.19, 2022.

(要約): Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of hepatocellular carcinoma. In contrast, approximately 30% are GS-negative without prominent nuclear or structural atypia. In this study, we examined the characteristics of the GS-negative tumors of TSOD mice. Twenty male TSOD mice were sacrificed at 40 weeks and a total of 21 tumors were analyzed by HE staining and immunostaining of GS, liver fatty acid-binding protein (L-FABP), serum amyloid A (SAA), and beta-catenin. With immunostaining for GS, six (29%) tumors were negative. Based on the histological and immunohistological characteristics, six GS-negative tumors were classified into several subtypes of human hepatocellular adenoma (HCA). One large tumor showed generally similar findings to inflammatory HCA, but contained small atypical foci with GS staining and partial nuclear beta-catenin expression suggesting malignant transformation. GS-negative tumors of TSOD mice contained features similar to various subtypes of HCA. Different HCA subtypes occurring in the same liver have been reported in humans; however, the diversity of patient backgrounds limits the ability to conduct a detailed, multifaceted analysis. TSOD mice may share similar mechanisms of HCA development as in humans. It is timely to review the pathogenesis of HCA from both genetic and environmental perspectives, and it is expected that TSOD mice will make further contributions in this regard.
(キーワード): Adenoma, Liver Cell / Animals / Carcinoma, Hepatocellular / 糖尿病 (diabetes mellitus) / Fatty Acid-Binding Proteins / Glutamate-Ammonia Ligase / Humans / 免疫組織化学 (immunohistochemistry) / Liver Neoplasms / 男性 (male) / Metabolic Syndrome / Mice / Mice, Obese / Non-alcoholic Fatty Liver Disease / Serum Amyloid A Protein / beta Catenin
(徳島大学機関リポジトリ): ● Metadata: 118862
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms231911923
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36233225; ● Summary page in Scopus @ Elsevier: 2-s2.0-85139812612

(徳島大学機関リポジトリ: 118862, DOI: 10.3390/ijms231911923, PubMed: 36233225, Elsevier: Scopus) Hitoshi Nishijima, Mizuki Sugita, Natsuka Umezawa, Naoki Kimura, Hirokazu Sasaki, Hiroshi Kawano, Yasuhiko Nishioka, Minoru Matsumoto, Takeshi Oya, Koichi Tsuneyama, Junko Morimoto and Mitsuru Matsumoto :
Development of organ-specific autoimmunity by dysregulated Aire expression.,
Immunology and Cell Biology, Vol.100, No.5, 371-377, 2022.

(要約): Deficiency for AIRE/Aire in both humans and mice results in the development of organ-specific autoimmune disease. We tested whether augmented and/or dysregulated AIRE/Aire expression might be also prone to the breakdown of self-tolerance. To define the effect of augmented Aire expression on the development of autoimmunity, antigen-specific clonal deletion and production of clonotypic regulatory T cells (Tregs) in the thymus were examined using mice expressing two additional copies of Aire in a heterozygous state (3xAire-knockin mice: 3xAire-KI). We found that both clonal deletion of autoreactive T cells and production of clonotypic Tregs in the thymus from 3xAire-KI were impaired in a T-cell receptor-transgenic system. Furthermore, 3xAire-KI females showed higher scores of experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein than wild-type littermates, suggesting that augmented Aire expression exacerbates organ-specific autoimmunity under disease-prone conditions. In humans, we found that one patient with amyopathic dermatomyositis showed CD3
(キーワード): Animals / 自己免疫 (autoimmunity) / Clonal Deletion / Encephalomyelitis, Autoimmune, Experimental / 女性 (female) / Humans / Immune Tolerance / Mice / Myelin-Oligodendrocyte Glycoprotein / Thymus Gland
(徳島大学機関リポジトリ): ● Metadata: 117817
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/imcb.12546
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35313042; ● Search Scopus @ Elsevier (PMID): 35313042; ● Search Scopus @ Elsevier (DOI): 10.1111/imcb.12546

(徳島大学機関リポジトリ: 117817, DOI: 10.1111/imcb.12546, PubMed: 35313042) Shoko Yamashita, Masaaki Nishi, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Yosuke Iwakawa, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada :
Gastric carcinoma with lymphoid stroma derived from hamartomatous inverted polyp with osteoclast-like giant cells: a case report.,
International Cancer Conference Journal, Vol.11, No.3, 196-200, 2022.

(要約): Gastric carcinomas with lymphoid stroma (GCLS) are characterized by prominent stromal infiltration of lymphocyte and account for 1-4% of gastric cancers. Although, osteoclast-like giant cells (OGC) have been reported in some GCLS, OGCs in gastric tumors is exceedingly rare. A 60-year-old woman presented to our hospital after the finding of a positive fecal blood test during a routine medical check. Esophagogastroduodenoscopy revealed a Type 0-III + IIc tumor in the middle part of the gastric body. Biopsy revealed a poorly differentiated tumor and she was referred to our department. Early phase computed tomography showed thickening of the wall in the middle of the gastric body and enlargement of nearby lymph nodes. Laparoscopic total gastrectomy was performed. Pathological examination revealed a hamartomatous inverted polyp (HIP) in the submucosal layer with tub2-por1 tumor in the HIP. Prominent lymphocytic infiltration and OGCs were found around the tumor. Immunohistochemical analysis showed that the tumor cells were negative for EBER, MLH-1, and MSH2, 6. These findings suggest that this tumor was a non-microsatellite instability (MSI)-high GCLS without Epstein-Barr virus (EBV) infection. The patient's postoperative course was uneventful and she was discharged 11 days after surgery. She remains well 3 years after surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s13691-022-00547-w
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35669900; ● Search Scopus @ Elsevier (PMID): 35669900; ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-022-00547-w

(DOI: 10.1007/s13691-022-00547-w, PubMed: 35669900) Mayuko Shimizu, Soichiroh Ishimaru, Wai Yee Yan Christine, Takeo Minamikawa, Takaaki Tsunematsu, Aiko Endoh, Takumi Kojima, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, MIYAGAMI Yuko, Hirohisa Ogawa, Takeshi Oya and Koichi Tsuneyama :
Establishment of an epicutaneously sensitized murine model of shellfish allergy and evaluation of skin condition by Raman microscopy.,
Applied Sciences, Vol.12, No.3566, 2022.

(徳島大学機関リポジトリ): ● Metadata: 117211
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/app12073566
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/app12073566

(徳島大学機関リポジトリ: 117211, DOI: 10.3390/app12073566) Junko Morimoto, Minoru Matsumoto, Ryuichiro Miyazawa, Takeshi Oya, Koichi Tsuneyama and Mitsuru Matsumoto :
No Major Impact of Two Homologous Proteins Ly6C1 and Ly6C2 on Immune Homeostasis.,
ImmunoHorizons, Vol.6, No.3, 202-210, 2022.

(要約): Ly6C comprises two homologous components of Ly6C1 and Ly6C2, and the expression of either of the Ly6C molecules defines unique functional subsets of monocytes. Ly6C is also expressed by other immune cell types, including Aire-expressing medullary thymic epithelial cells. Because the role of Ly6C expression in determining the functional subsets remains unclear, we generated mice deficient for both Ly6C1 and Ly6C2 with CRISPR-Cas9mediated deletion. Mice deficient for Ly6C1/Ly6C2 showed no major alterations in the subsets and function of monocyte and other immune cells, including the cells involved in the dextran sulfate sodium saltinduced colitis model. By generating the mice deficient for Ly6C1 alone, we have also investigated the expression pattern of Ly6C1 and Ly6C2 in immune cells. Except for medullary thymic epithelial cells and CD4 single-positive T cells, immune cells predominantly expressed Ly6C2. Thus, despite the importance as a marker with a unique differential expression pattern, the Ly6C molecules have no major impact on determining the functional subsets and maintaining immune homeostasis.
(徳島大学機関リポジトリ): ● Metadata: 117315
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/immunohorizons.2100114
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4049/immunohorizons.2100114

(徳島大学機関リポジトリ: 117315, DOI: 10.4049/immunohorizons.2100114) Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Kazuyoshi Hosomichi, Nobuko Akiyama, Taishin Akiyama, Takeshi Oya, Koichi Tsuneyama, Hideyuki Yoshida and Mitsuru Matsumoto :
Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens.,
The Journal of Immunology, Vol.208, No.2, 303-320, 2022.

(要約): The deficiency of Aire, a transcriptional regulator whose defect results in the development of autoimmunity, is associated with reduced expression of tissue-restricted self-Ags (TRAs) in medullary thymic epithelial cells (mTECs). Although the mechanisms underlying Aire-dependent expression of TRAs need to be explored, the physical identification of the target(s) of Aire has been hampered by the low and promiscuous expression of TRAs. We have tackled this issue by engineering mice with augmented Aire expression. Integration of the transcriptomic data from Aire-augmented and Aire-deficient mTECs revealed that a large proportion of so-called Aire-dependent genes, including those of TRAs, may not be direct transcriptional targets downstream of Aire. Rather, Aire induces TRA expression indirectly through controlling the heterogeneity of mTECs, as revealed by single-cell analyses. In contrast, Ccl25 emerged as a canonical target of Aire, and we verified this both in vitro and in vivo. Our approach has illuminated the Aire's primary targets while distinguishing them from the secondary targets.
(キーワード): Animals / Autoantigens / Autoimmunity / Chemokines, CC / Epithelial Cells / Gene Expression Regulation / Gene Knock-In Techniques / Gene Knockout Techniques / Mice / Mice, Inbred C57BL / Mice, Inbred NOD / Mice, Transgenic / Thymus Gland / Transcription Factors / Transcription, Genetic
(徳島大学機関リポジトリ): ● Metadata: 117482
(出版サイトへのリンク): ● Publication site (DOI): 10.4049/jimmunol.2100692
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34930780; ● Search Scopus @ Elsevier (PMID): 34930780; ● Search Scopus @ Elsevier (DOI): 10.4049/jimmunol.2100692

(徳島大学機関リポジトリ: 117482, DOI: 10.4049/jimmunol.2100692, PubMed: 34930780) Mayuko Shimizu, Yosuke Tsuchiyama, Yuki Morimoto, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Takeshi Oya, Hirohisa Ogawa, Michiko Yamashita, Satoru Matsuda, Katsuhisa Omagari, Shu Taira and Koichi Tsuneyama :
A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages,
The American Journal of Pathology, Vol.192, No.1, 31-42, 2022.

(要約): Various cells, such as macrophages and hepatic stellate cells, interact in the generation of fibrosis in nonalcoholic steatohepatitis (NASH), but the mechanism remains unclear. We employed a high-fat/cholesterol/cholate (HFCC) diet to generate a model of NASH-related fibrosis and investigate the pathogenesis of fibrosis. Two mouse strains differing in susceptibility to obesity, the susceptible strain C57BL/6J and the relatively resistant strain A/J, developed hepatic histologic features of NASH, including fat deposition, intralobular inflammation, hepatocyte ballooning, and fibrosis, after 9 weeks of HFCC diet feeding. The severity of hepatic inflammation and fibrosis was greater in A/J mice than in C57BL/6J mice. A/J mice fed the HFCC diet exhibited characteristic CD204-positive lipid-laden macrophage aggregation in hepatic parenchyma. Polarized light visualized the Maltese cross (namely, cholesterol crystals within the aggregated macrophages). Moreover, fibrosis developed in a ring shape from the periphery of the aggregated macrophages (ie, the starting point of fibrosis could be visualized histologically). Furthermore, matrix-assisted laser desorption/ionization mass spectrometry imaging analysis detected a molecule at m/z 772.462, which corresponds to the protonated ion of phosphatidylcholine [P-18:1 (11Z)/18:0] and phosphatidylethanolamine [18:0/20:2 (11Z, 14Z)], in aggregated macrophages adjacent to the fibrotic lesions. In conclusion, the present HFCC diet-fed A/J model provides an ideal tool to study fibrogenesis and enables novel insights into the pathophysiology of NASH-related fibrosis.
(キーワード): Liver fibrosis / マクロファージ (macrophage) / animal model / コレステロール (cholesterol) / cholate
(徳島大学機関リポジトリ): ● Metadata: 116411
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajpath.2021.10.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34710382; ● Search Scopus @ Elsevier (PMID): 34710382; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajpath.2021.10.002

(徳島大学機関リポジトリ: 116411, DOI: 10.1016/j.ajpath.2021.10.002, PubMed: 34710382) Mayuko Shimizu, Takeshi Kageyama, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Satoshi Sumida, Takumi Kakimoto, Yuko Miyakami, Ryosuke Nagatomo, Koichi Inoue, Chunmei Cheng and Koichi Tsuneyama :
Verification of the Impact of Blood Glucose Level on Liver Carcinogenesis and the Efficacy of a Dietary Intervention in a Spontaneous Metabolic Syndrome Model,
International Journal of Molecular Sciences, Vol.22, No.23, 12844, 2021.

(要約): Metabolic syndrome (MS) is a risk factor for type 2 diabetes mellitus, vascular inflammation, atherosclerosis, and renal, liver, and heart diseases. Non-alcoholic steatohepatitis (NASH) is a progressive representative liver disease and may lead to the irreversible calamities of cirrhosis and hepatocellular carcinoma. Metabolic disorders such as hyperglycemia have been broadly reported to be related to hepatocarcinogenesis in NASH; however, direct evidence of a link between hyperglycemia and carcinogenesis is still lacking. Tsumura Suzuki Obese Diabetic (TSOD) mice spontaneously develop metabolic syndrome, including obesity, insulin resistance, and NASH-like liver phenotype, and eventually develop hepatocellular carcinomas. TSOD mice provide a spontaneous human MS-like model, even with significant individual variations. In this study, we monitored mice in terms of their changes in blood glucose levels, body weights, and pancreatic and liver lesions over time. As a result, liver carcinogenesis was delayed in non-hyperglycemic TSOD mice compared to hyperglycemic mice. Moreover, at the termination point of 40 weeks, liver tumors appeared in 18 of 24 (75%) hyperglycemic TSOD mice; in contrast, they only appeared in 5 of 24 (20.8%) non-hyperglycemic mice. Next, we investigated three kinds of oligosaccharide that could lower blood glucose levels in hyperglycemic TSOD mice. We monitored the levels of blood and urinary glucose and assessed pancreatic lesions among the experimental groups. As expected, significantly lower levels of blood and urinary glucose and smaller deletions of Langerhans cells were found in TSOD mice fed with milk-derived oligosaccharides (galactooligosaccharides and lactosucrose). At the age of 24 weeks, mild steatohepatitis was found in the liver but there was no evidence of liver carcinogenesis. Steatosis in the liver was alleviated in the milk-derived oligosaccharide-administered group. Taken together, suppressing the increase in blood glucose level from a young age prevented susceptible individuals from diabetes and the onset of NAFLD/NASH, as well as carcinogenesis. Milk-derived oligosaccharides showed a lowering effect on blood glucose levels, which may be expected to prevent liver carcinogenesis.
(徳島大学機関リポジトリ): ● Metadata: 116736
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms222312844
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34884650; ● Search Scopus @ Elsevier (PMID): 34884650; ● Search Scopus @ Elsevier (DOI): 10.3390/ijms222312844

(徳島大学機関リポジトリ: 116736, DOI: 10.3390/ijms222312844, PubMed: 34884650) Katsuki Miyazaki, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Tetsuya Ikemoto, Satoru Imura, Haun Hu, Hisayoshi Morioka, Koichi Tsuneyama and Mitsuo Shimada :
Stromal tumor-infiltrating lymphocytes level as a prognostic factor for resected intrahepatic cholangiocarcinoma and its prediction by apparent diffusion coefficient.,
International Journal of Clinical Oncology, Vol.26, No.12, 2265-2274, 2021.

(要約): Tumor-infiltrating lymphocytes (TILs) are a prognostic factor or an indicator of chemotherapy response for various malignancies. The aim of this study was to investigate the prognostic impact of TILs in resected intrahepatic cholangiocarcinoma (IHCC). We also investigated the usefulness of the apparent diffusion coefficient (ADC) in diffusion-weighted magnetic resonance imaging (DW-MRI) to predict TILs. We enrolled 23 patients with IHCC who underwent initial hepatic resection in Tokushima University Hospital from 2006 to 2017. We evaluated stromal TILs in the tumor marginal area and central area in surgical specimens. Patients were divided into low vs high stromal TILs groups. We analyzed the patients' clinicopathological factors, including prognosis, according to the degree of stromal TILs. We also analyzed the correlation between stromal TILs and the minimum ADC value. Stromal TILs in the marginal area reflected overall survival more accurately than that in the central area. Additionally, marginal low TILs was significantly associated with lymph node metastasis and portal vein invasion. Both overall- and disease-free survival rates in the marginal low TILs group were significantly worse than those in the marginal high TILs group (P < 0.05). In the multivariate analysis, marginal low TILs were an independent prognostic factor for both overall- and disease-free survival (P < 0.05), and marginal low TILs were significantly associated with lower minimum ADC values (P < 0.02). Stromal TILs, especially in the marginal area, might demonstrate prognostic impact in patients with IHCC. Moreover, the ADC values from MRI may predict TILs in IHCC tumor tissue.
(キーワード): Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Diffusion Magnetic Resonance Imaging / Humans / Lymphocytes, Tumor-Infiltrating / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-021-02026-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34596803; ● Search Scopus @ Elsevier (PMID): 34596803; ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-02026-3

(DOI: 10.1007/s10147-021-02026-3, PubMed: 34596803) Tomoko Kobayashi, Mayuko Shimizu, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Yuki Morimoto, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Chunmei Cheng and Koichi Tsuneyama :
Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.,
Pathology, Research and Practice, Vol.225, No.153559, 2021.

(要約): Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. An insulin-recruitment to DIAR-nSTZ mice showed an increased frequency of HCC during the first 12 weeks of age, although the diabetic indications notably improved. To elucidate the role of hyperglycemia in hepato-carcinogenesis, we performed a head-to-head comparative study by using 4CS mice and DIAR mice with n-STZ treatment. Newborn 4CS mice and DIAR mice were divided into STZ treated group and control group. The blood glucose levels of DIAR-nSTZ mice increased at age of eight weeks, while that of 4CS-nSTZ mice were maintained in the normal range. At eight weeks old, three out of five DIAR-nSTZ mice (60%) and one out of ten 4CS-nSTZ mice (10%) developed multiple liver tumors. At age of 12 weeks old, all eight of DIAR-nSTZ mice (100%) and two of 10 4CS-nSTZ mice (20%) developed multiple liver tumors. At 16 weeks old, all animals of DIAR-nSTZ and 4CS-nSTZ mice occurred liver tumors. DIAR-nSTZ showed hyperglycemia and HCC, and 4CS-nSTZ developed HCC without hyperglycemia. These results were interpreted that the onset of HCC maybe not related to the presence or absence of hyperglycemia but nSTZ treatment. On the other hand, since the carcinogenesis of 4CS-nSTZ is delayed compared to DIAR-nSTZ, hyperglycemia may play a role in the progression of carcinogenesis. Histologically, the liver tumor appeared irregularly trabecular arrangements of hepatocytes with various degrees of nuclear atypia. By immunohistochemical analyses, all liver tumors showed positive staining of glutamine synthetase (GS), an established human HCC marker. The expression pattern of GS was divided into a strong diffuse pattern and weak patchy pattern, respectively. The liver tumor showing the weak GS-patchy pattern expressed biliary/stem markers, EpCAM, and SALL4, partially. Because 4CS-nSTZ mice did not show any metabolic complications such as gaining body weight or high blood glucose level, it is a unique animal model with a simple condition to investigate hepatic carcinogenesis by excluding other factors.
(徳島大学機関リポジトリ): ● Metadata: 118286
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.prp.2021.153559
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34325313; ● Search Scopus @ Elsevier (PMID): 34325313; ● Search Scopus @ Elsevier (DOI): 10.1016/j.prp.2021.153559

(徳島大学機関リポジトリ: 118286, DOI: 10.1016/j.prp.2021.153559, PubMed: 34325313) Yuki Morimoto, Takeshi Oya, Mayuko Shimizu, Minoru Matsumoto, Hirohisa Ogawa, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Chunmei Cheng and Koichi Tsuneyama :
Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells.,
Acta Cytologica, Vol.65, No.5, 430-439, 2021.

(要約): PESI-MS presented a promising potential as a novel diagnostic modality for swiftly acquiring specific cytological information.
(徳島大学機関リポジトリ): ● Metadata: 116345
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000516639
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34098551; ● Search Scopus @ Elsevier (PMID): 34098551; ● Search Scopus @ Elsevier (DOI): 10.1159/000516639

(徳島大学機関リポジトリ: 116345, DOI: 10.1159/000516639, PubMed: 34098551) Shoko Yamashita, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shinichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada :
A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2.,
World Journal of Surgical Oncology, Vol.19, No.1, 142, 2021.

(要約): This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2.
(キーワード): Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Humans / Prognosis / Proto-Oncogene Proteins c-bcl-2 / Receptors, Somatostatin
(徳島大学機関リポジトリ): ● Metadata: 116986
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s12957-021-02216-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33962620; ● Search Scopus @ Elsevier (PMID): 33962620; ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02216-3

(徳島大学機関リポジトリ: 116986, DOI: 10.1186/s12957-021-02216-3, PubMed: 33962620) 山下理子, 中園雅彦, 春藤譲治, 黒田直人, 尾矢剛志 :
2002年以前に報告された日本人胃のHamartomatous inverted polyp (inverted hyperplastic polyp)の臨床病理学的所見の検討,
四国医学雑誌, Vol.76, No.1,2, 61-68, 2020年.

(要約): Gastric hamartomatous inverted polyp (g-HIP) is rare gastric elevated lesion forming endophytic growth pattern which etiology remains unknown. G-HIP is said to be associated with gastric cancer and gastritis. We systematically reviewed Japanese g-HIP's clinicopathological features reported before2002. Japanese g-HIP amount to20lesions,18patients ; 7(38 9%)were males and 11(61 1%)were females. The mean age of patients was 60 2 years old. The mean size of the lesions was21 7millimeter. No of the polyp shape was Yamada type IV7, Yamada type I/flat elevation 6, Yamada type III 4 and Yamada II 3, respectively. The site of the lesions was Body11, Cardia3, Fornix3and Antrum1, respectively. In12described cases, accompanied lesion was Gastritis, Carcinoma, GCP, Hyperplastic polyp, GIST and remnant stomach due to ulcer. Of the submucosal shaped(Yamada type I/flat elevation)g-HIP,50% has GCP and62 5% has gastric cancer. The common feature of g-HIP was pyloric gland-like mucous gland proliferation and cystic dilatation in the H. pylori era of Japan.
(キーワード): hamartomatous hyperplastic polyp / inverted hyperplastic polyp / stomach / gastritis cystica profunda / Helicobacter pylori
(徳島大学機関リポジトリ): ● Metadata: 114857
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050566774761706624

(徳島大学機関リポジトリ: 114857, CiNii: 1050566774761706624) Tomoi Sato, Ichiro Muto, Takeshi Oya and Takeshi Sakai :
Invasive Paget's disease of the male nipple: a case report.,
Journal of Surgical Case Reports, Vol.2017, No.7, 1-3, 2017.

(要約): , mastectomy and sentinel lymph node biopsy were performed. MPD with dermal invasion is extremely rare, and only one male case has been reported in the English literature; therefore, the current case is the second case of male MPD with dermal invasion.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/jscr/rjx137
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28775835; ● Search Scopus @ Elsevier (PMID): 28775835; ● Search Scopus @ Elsevier (DOI): 10.1093/jscr/rjx137

(DOI: 10.1093/jscr/rjx137, PubMed: 28775835) 林真也, 池田友美, 橋詰香織, 八木美菜, 上原桂月, 建部勝彦, 高橋直子, 尾矢剛志, 酒井剛, 岩渕三哉, 関谷政雄 :
当院における甲状腺穿刺吸引細胞診鑑別困難例の検討,
新潟県臨床検査技師会誌, Vol.56, No.2, 72-77, 2016年. Shoji Seki, Noriyuki Tsumaki, Hiraku Motomura, Makiko Nogami, Yoshiharu Kawaguchi, Takeshi Hori, Kayo Suzuki, Yasuhito Yahara, Mami Higashimoto, Takeshi Oya, Shiro Ikegawa and Tomoatsu Kimura :
Cartilage intermediate layer protein promotes lumbar disc degeneration.,
Biochemical and Biophysical Research Communications, Vol.446, No.4, 876-881, 2014.

(要約): Lumbar disc disease (LDD) is one of the most common musculoskeletal disorders, and accompanies intervertebral disc degeneration. CILP encodes cartilage intermediate layer protein, which is highly associated with LDD. Moreover, CILP inhibits transcriptional activation of cartilage matrix genes in nucleus pulposus (NP) cells in vitro by binding to TGF-β1 and inhibiting the phosphorylation of Smads. However, the aetiology and mechanism of pathogenesis of LDD in vivo are unknown. To demonstrate the role of CILP in LDD in vivo, we generated transgenic mice that express CILP specifically in the intervertebral disc tissues and assessed whether CILP exacerbates disc degeneration. Degeneration of the intervertebral discs was assessed using magnetic resonance imaging (MRI) and histology. The level of phosphorylation of Smad2/3 in intervertebral discs was measured to determine whether overexpressed CILP suppressed TGF-beta signalling. Although the macroscopic skeletal phenotype of transgenic mice appeared normal, histological findings revealed significant degeneration of lumbar discs. MRI analysis of the lumbar intervertebral discs indicated a significantly lower signal intensity of the nucleus pulposus where CILP was overexpressed. Intervertebral disc degeneration was also observed. The number of phosphorylation of Smad2/3 immuno-positive cells in the NP significantly was decreased in CILP transgenic mice compared with normal mice. In summary, overexpression of CILP in the NP promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of LDD.
(キーワード): Animals / Humans / Intervertebral Disc / Intervertebral Disc Degeneration / Intervertebral Disc Displacement / Lumbar Vertebrae / 磁気共鳴映像法 (magnetic resonance imaging) / ノックアウトマウス (knockout mice) / Mice, Transgenic / Pyrophosphatases / RNA, Messenger / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2014.03.025
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24631904; ● Search Scopus @ Elsevier (PMID): 24631904; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2014.03.025

(DOI: 10.1016/j.bbrc.2014.03.025, PubMed: 24631904) Kayo Suzuki, Taketoshi Yasuda, Takeshi Hori, Takeshi Oya, Kenta Watanabe, Masahiko Kanamori and Tomoatsu Kimura :
Pleomorphic hyalinizing angiectatic tumor arising in the thigh: A case report.,
Oncology Letters, Vol.7, No.4, 1249-1252, 2014.

(要約): Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare non-metastasizing tumors of uncertain lineage. The current study presents a case of PHAT arising in the thigh of a 68-year-old female and examines the clinicopathological characteristics of the tumor. Magnetic resonance imaging (MRI) revealed an intramuscular mass located in the adductor longus. The tumor was surrounded by lipomatous tumor. Wide resectioning was performed for the internal tumor, whereas intralesional resectioning was performed for the external tumor. Histopathologically, the internal lesion was diagnosed as a PHAT and the external lesion was diagnosed as an hemosiderotic fibrolipomatous lesion (HFLL). No recurrence or metastases were identified during the 6-year follow-up period. As the adipose tissue surrounding the PHAT resembled a HFLL, therefore, the association between 'early PHAT' and HFLL is discussed. Although PHATs may represent low-grade sarcomas, HFLLs may be benign tumors.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2014.1883
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24944701; ● Search Scopus @ Elsevier (PMID): 24944701; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2014.1883

(DOI: 10.3892/ol.2014.1883, PubMed: 24944701) 林真也, 橋詰香織, 北澤綾, 上原桂月, 武田順子, 建部勝彦, 尾矢剛志, 酒井剛, 関谷政雄 :
乳腺組織における検体処理時間短縮の試み,
新潟県立中央病院医誌, Vol.22, No.1, 11-13, 2014年. Shoji Seki, Yoshiharu Kawaguchi, Hirokazu Ishihara, Takeshi Oya and Tomoatsu Kimura :
Lumbar spinal stenosis due to a large calcified mass in the ligamentum flavum.,
Asian Spine Journal, Vol.7, No.3, 236-241, 2013.

(要約): We describe a rare case of lumbar spinal stenosis due to a large calcified mass in the ligamentum flavum. This patient presented with a 12-month history of severe right leg pain and intermittent claudication. A computed tomography scan was performed, revealing a large calcified mass on the ligamentum flavum at the right-hand side of the lumbar spinal canal. We performed a laminotomy at the L4/5 level with resection of the calcified mass from the ligamentum flavum. The findings of various analyses suggested that the calcified mass consisted mostly of Ca3(PO4)2 and calcium phosphate intermixed with protein and water. The calcified mass in the ligamentum flavum was causing lumbar spinal stenosis. Surgical decompression by resection of the mass was effective in this patient. The calcified material was composed mainly of elements derived from calcium phosphate. Degenerative changes in the ligamentum flavum of the lumbar spine may have been involved in the production of this calcified mass.
(出版サイトへのリンク): ● Publication site (DOI): 10.4184/asj.2013.7.3.236
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24066222; ● Search Scopus @ Elsevier (PMID): 24066222; ● Search Scopus @ Elsevier (DOI): 10.4184/asj.2013.7.3.236

(DOI: 10.4184/asj.2013.7.3.236, PubMed: 24066222) Tomoi Sato, Ichiro Muto, Masaki Hasegawa, Takashi Aono, Takeshi Sakai and Takeshi Oya :
Ductal carcinoma in situ with isolated tumor cells in the sentinel lymph node in a 17-year-old adolescent girl.,
Breast Cancer, Vol.20, No.3, 271-274, 2013.

(要約): We report here a quite rare case of ductal carcinoma in situ (DCIS) with isolated tumor cells in the sentinel lymph node in a 17-year-old adolescent girl whose mother also had advanced breast cancer. Findings included an elastic mass in the right breast accompanied by serous nipple discharge. DCIS of the breast was diagnosed following core needle biopsy. Although no invasive focus was clearly observed in the mastectomy sample, isolated tumor cells were found in the sentinel lymph node. Although the family refused genetic testing, a hereditary abnormality may have played a role in the carcinogenesis in this case.
(キーワード): Adolescent / Breast Neoplasms / Carcinoma, Ductal, Breast / Carcinoma, Intraductal, Noninfiltrating / Female / Humans / Lymph Nodes / Neoplasm Staging / Prognosis / Sentinel Lymph Node Biopsy
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-010-0205-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20411367; ● Search Scopus @ Elsevier (PMID): 20411367; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-010-0205-x

(DOI: 10.1007/s12282-010-0205-x, PubMed: 20411367) Kenji Yasuda, Akira Komiya, Akihiko Watanabe, Akihiro Morii, Takeshi Oya, Osamu Nagakawa, Yasuyoshi Fujiuchi and Hideki Fuse :
Expression of Hepatocyte growth factor activator inhibitor type-1 (HAI-1) in prostate cancer.,
Anticancer Research, Vol.33, No.2, 575-581, 2013.

(要約): It is suggested that HAI-1 may play an important role in the pathogenesis of CRPC.
(キーワード): Aged / Androgen Antagonists / Biomarkers, Tumor / Disease Progression / Disease-Free Survival / Drug Resistance, Neoplasm / Humans / 免疫組織化学 (immunohistochemistry) / Male / Neoplasm Grading / Neoplasm Staging / Prostatic Neoplasms / Proteinase Inhibitory Proteins, Secretory
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23393351; ● Search Scopus @ Elsevier (PMID): 23393351

(PubMed: 23393351) 内山昌則, 村田大樹, 尾矢剛志 :
臨床報告幼児巨大ウィルムス腫瘍(腎芽腫)の1手術例,
臨床外科, Vol.67, No.10, 1322-1326, 2012年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390002209886624512

(CiNii: 1390002209886624512) H Suzuki, I Usui, I Kato, Takeshi Oya, Y Kanatani, S Fujisaka, S Senda, Y Ishii, M Urakaze, A Mahmood, S Takasawa, H Okamoto, M Kobayashi, K Tobe and M Sasahara :
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice.,
Diabetologia, Vol.54, No.11, 2953-2962, 2011.

(要約): The activation of platelet-derived growth factor receptor-β (PDGFR-β) signalling is increased in the glomeruli and tubules of diabetic animals. In this study, we examined the role of PDGFR-β signalling during the development of diabetic nephropathy. We recently generated pancreatic beta cell-specific Ca(2+)/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice (CaMKIIα mice), which show very high plasma glucose levels up to 55.5 mmol/l and exhibit the features of diabetic nephropathy. These mice were crossed with conditional knockout mice in which Pdgfr-β (also known as Pdgfrb) was deleted postnatally. The effect of the deletion of the Pdgfr-β gene on diabetic nephropathy in CaMKIIα mice was evaluated at 10 and 16 weeks of age. The plasma glucose concentrations and HbA(1c) levels were elevated in the CaMKIIα mice from 4 weeks of age. Variables indicative of diabetic nephropathy, such as an increased urinary albumin/creatinine ratio, kidney weight/body weight ratio and mesangial area/glomerular area ratio, were observed at 16 weeks of age. The postnatal deletion of the Pdgfr-β gene significantly decreased the urinary albumin/creatinine ratio and mesangial area/glomerular area ratio without affecting the plasma glucose concentration. Furthermore, the increased oxidative stress in the kidneys of the CaMKIIα mice as shown by the increased urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion and the increased expression of NAD(P)H oxidase 4 (NOX4), glutathione peroxidase 1 (GPX1) and manganese superoxide dismutase (MnSOD) was decreased by Pdgfr-β gene deletion. The activation of PDGFR-β signalling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKIIα mice.
(キーワード): Amino Acid Substitution / Animals / Biomarkers / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Crosses, Genetic / Diabetic Nephropathies / Disease Progression / Glomerular Mesangium / Insulin-Secreting Cells / Kidney / Male / Mesangial Cells / Mice / Mice, Inbred C57BL / Mice, Knockout / Mice, Transgenic / Mutant Proteins / Oxidative Stress / Oxidoreductases / Receptor, Platelet-Derived Growth Factor beta / Signal Transduction
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00125-011-2270-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21833587; ● Search Scopus @ Elsevier (PMID): 21833587; ● Search Scopus @ Elsevier (DOI): 10.1007/s00125-011-2270-x

(DOI: 10.1007/s00125-011-2270-x, PubMed: 21833587) Norifumi Shioda, Shigeki Moriguchi, Takeshi Oya, Yoko Ishii, Jie Shen, Takako Matsushima, Hisao Nishijo, Masakiyo Sasahara and Kohji Fukunaga :
Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor β-receptor lacking mice.,
Hippocampus, Vol.22, No.6, 1371-1378, 2011.

(要約): The physiological role of platelet-derived growth factor (PDGF) in the central nervous system (CNS) synaptic function remains uncharacterized. Here we identify physiological roles of PDGF receptor-β (PDGFR-β) in the CNS by conditional knockout of the gene encoding it. In the hippocampus, PDGFR-β colocalized immunohistochemically with both presynaptic synaptophysin and postsynaptic density-95 (PSD-95). In the hippocampal CA1 region, expression levels of postsynaptic proteins, including spinophilin, drebrin, and PSD-95, were significantly decreased in PDGFR-β knockout mice, although presynaptic synaptophysin levels remained comparable to controls. Interestingly, in hippocampal CA1 pyramidal neurons, dendritic spine density in PDGFR-β knockout mice was significantly decreased compared with that seen in wild-type mice, although spine length and number of dendritic branches remained unchanged. Consistent with these findings, impairment in hippocampal long-term potentiation (LTP) and in hippocampus-dependent memory formation were seen in PDGFR-β knockout mice. These results suggest PDGFR-β plays critical roles in spine morphology and memory formation in mouse brain.
(キーワード): Animals / Dendritic Spines / Hippocampus / Memory Disorders / Mice / ノックアウトマウス (knockout mice) / Neurons / Random Allocation / Receptor, Platelet-Derived Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/hipo.20973
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21997856; ● Search Scopus @ Elsevier (PMID): 21997856; ● Search Scopus @ Elsevier (DOI): 10.1002/hipo.20973

(DOI: 10.1002/hipo.20973, PubMed: 21997856) Noriko Nakajima, Yuko Sato, Harutaka Katano, Hideki Hasegawa, Toshio Kumasaka, Satoru Hata, Shinya Tanaka, Tomonori Amano, Takahiko Kasai, Ja-Mun Chong, Toshihiko Iizuka, Toshihiko Iiduka, Iwao Nakazato, Yohko Hino, Akihiko Hamamatsu, Hisashi Horiguchi, Tomoyuki Tanaka, Akio Hasegawa, Akio Hasagawa, Yoshiaki Kanaya, Reiko Oku, Takeshi Oya and Tetsutaro Sata :
Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection.,
Modern Pathology, Vol.25, No.1, 1-13, 2011.

(要約): Twenty autopsy cases with 2009 pandemic influenza A (2009 H1N1) virus infection, performed between August 2009 and February 2010, were histopathologically analyzed. Hematoxylin-eosin staining, immunohistochemistry for type A influenza nucleoprotein antigen, and real-time reverse transcription-PCR assay for viral RNA were performed on formalin-fixed and paraffin-embedded specimens. In addition, the D222G amino acid substitution in influenza virus hemagglutinin, which binds to specific cell receptors, was analyzed in formalin-fixed and paraffin-embedded trachea and lung sections by direct sequencing of PCR-amplified products. There were several histopathological patterns in the lung according to the most remarkable findings in each case: acute diffuse alveolar damage (DAD) with a hyaline membrane (four cases), organized DAD (one case), acute massive intra-alveolar edema with variable degrees of hemorrhage (three cases), neutrophilic bronchopneumonia (five cases) and tracheobronchitis with limited histopathological changes in alveoli (four cases). In two cases, the main findings were due to preexisting disease. Influenza virus antigen was only detected in the respiratory tract in 10 cases by immunohistochemistry. The antigen was detected in type II pneumocytes (three cases) in the epithelial cells of the trachea, bronchi and glands (six cases), and in the epithelial cells in both of the above (one case). The four cases with acute DAD presented with antigen-positive type II pneumocytes. In one case, the D222G substitution was detected in the lung as a major sequence, although 222D was prominent in the trachea, suggesting that selection of the viral clones occurred in the respiratory tract. In five cases, the pathogenesis of 2009 H1N1 was confirmed to be viral infection in pneumocytes, which caused severe alveolar damage and fatal viral pneumonia. Further studies on both host and viral factors in autopsy or biopsy materials will be essential to elucidate the other pathogenic factors involved in influenza virus infection.
(キーワード): Adolescent / Adult / Aged / Aged, 80 and over / Antigens, Viral / Autopsy / Child / Child, Preschool / DNA Mutational Analysis / Female / Fixatives / Formaldehyde / Hemagglutinin Glycoproteins, Influenza Virus / Humans / 免疫組織化学 (immunohistochemistry) / Influenza A Virus, H1N1 Subtype / Influenza, Human / 日本 (Japan) / Lung / Male / Middle Aged / Mutation / Pandemics / Paraffin Embedding / RNA, Viral / Real-Time Polymerase Chain Reaction / Reverse Transcriptase Polymerase Chain Reaction / Time Factors / Tissue Fixation / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/modpathol.2011.125
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21874012; ● Search Scopus @ Elsevier (PMID): 21874012; ● Search Scopus @ Elsevier (DOI): 10.1038/modpathol.2011.125

(DOI: 10.1038/modpathol.2011.125, PubMed: 21874012) 尾矢剛志, 楡井淳, 青木信将 :
急激な経過をたどりウイルス性疾患が疑われた2剖検例,
新潟県立病院医学会誌, No.59, 29-33, 2011年. Taizo Nakagawa, Kiyoshi Izumino, Yoko Ishii, Takeshi Oya, Takeru Hamashima, Shen Jie, Shin Ishizawa, Fumihiro Tomoda, Toshihiko Fujimori, Yo-ichi Nabeshima, Hiroshi Inoue and Masakiyo Sasahara :
Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.,
Nephrology, Dialysis, Transplantation, Vol.26, No.2, 458-468, 2010.

(要約): Mice depleted of PDGFR-β (Deletant) survived without showing apparent abnormalities. In glomerulus of Deletant, mesangial PDGFR-β expression was decreased. The glomerular cell numbers were low, and the ageing-associated increment of mesangial matrix area was suppressed in Deletant as compared with control mice with conserved PDGFR-β expression (Floxed) at 48 weeks of age. At 2 weeks after subtotal nephrectomy, albuminuria and the elevation of blood urea nitrogen were aggravated in Deletant. At this time, Deletant showed specific glomerular changes that included many hypertrophic podocytes and collapsed capillaries. At 12 weeks after subtotal nephrectomy, the kidney function in Deletant restored to the level of Floxed; however, the Deletant glomeruli showed dilated capillaries, decreased cell number and reduced mesangial matrix area with less extended mesangial cell processes as compared with Floxed.
(キーワード): Adaptation, Physiological / 老化 (aging) / Animals / Glomerular Mesangium / Kidney Glomerulus / Male / Mice / ノックアウトマウス (knockout mice) / Nephrectomy / Receptor, Platelet-Derived Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ndt/gfq468
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20693161; ● Search Scopus @ Elsevier (PMID): 20693161; ● Search Scopus @ Elsevier (DOI): 10.1093/ndt/gfq468

(DOI: 10.1093/ndt/gfq468, PubMed: 20693161) Yutaka Tsubata, Fumihiro Akiyama, Takeshi Oya, Junya Ajiro, Takako Saeki, Shinichi Nishi and Ichiei Narita :
IgG4-related chronic tubulointerstitial nephritis without autoimmune pancreatitis and the time course of renal function.,
Internal Medicine, Vol.49, No.15, 1593-1598, 2010.

(要約): We report an elderly man with chronic tubulointerstitial nephritis (TIN) showing a high serum immunoglobulin G4 (IgG4) concentration. His serum creatinine (Scr) level had gradually increased from 0.9 mg/dL to 5.6 mg/dL over 18 months. Renal biopsy showed marked IgG4-positive plasma cell infiltration in the interstitium without glomerular abnormalities and IgG4-related TIN was diagnosed. Oral prednisolone reduced his Scr and IgG4 levels immediately. The present case indicates that IgG4-related TIN can not only progress rapidly but also chronically over a long period without significant urinary abnormalities, and we should consider hidden IgG4-related TIN in cases of chronic renal insufficiency.
(キーワード): Aged / Autoimmune Diseases / Chronic Disease / Humans / Immunoglobulin G / Kidney / Kidney Function Tests / Male / Nephritis, Interstitial / Pancreatitis / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.49.3787
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20686296; ● Search Scopus @ Elsevier (PMID): 20686296; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.49.3787

(DOI: 10.2169/internalmedicine.49.3787, PubMed: 20686296) 田村哲郎, 近貴志, 青木悟, 塚本佳広, 尾矢剛志, 関泰弘 :
Subclinical Cushing病に伴ったCrooke cell microadenomaの1例,
日本内分泌学会雑誌, Vol.85, No.Suppl., 127-129, 2009年. Takashi Yamazaki, Hemragul Sabit, Takeshi Oya, Yoko Ishii, Takeru Hamashima, Ayano Tokunaga, Shin Ishizawa, Shen Jie, Yoichi Kurashige, Takako Matsushima, Isao Furuta, Makoto Noguchi and Masakiyo Sasahara :
Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.,
Journal of the Peripheral Nervous System : JPNS, Vol.14, No.3, 165-176, 2009.

(要約): A number of receptor tyrosine kinases (RTKs) and the downstream phosphatidylinositol-3-kinase (PI3K)/Akt and mitogen-activated protein (MAP) kinase signaling pathways have been critically involved in peripheral nerve regeneration. Here, we examined the activation of PI3K/Akt and MAP kinase pathways, and platelet-derived growth factor receptors (PDGFRs) in the distal segments of crushed rat sciatic nerve from 3 to 28 days after injury. In Western blot analyses, the phosphorylated forms of extracellular signal-regulated protein kinase (ERK) and c-Jun NH(2)-terminal kinases (JNKs) were highly augmented on days 3 and 7 and on days 7 and 14 after injury, respectively. Phosphorylated Akt and p38 consistently increased from 3 to 28 days after injury. Phosphorylated PDGFR-alpha and -beta were also increased from 3 to 14 days. In the immunohistological analyses, phosphorylated ERK and PDGFR-alpha were co-localized in many activated Schwann cells and regrowing axons 3 days after injury, while PDGFR-beta was localized in a few spindle-shaped cells. The detected temporal profile of RTK signaling appears to be crucial for the regulation of Schwann cell proliferation and following redifferentiation. Furthermore, the immunohistological studies suggested a role of ERK and PDGFR-alpha in axon regeneration as well.
(キーワード): Animals / Blotting, Western / Enzyme Activation / Fluorescent Antibody Technique / 免疫組織化学 (immunohistochemistry) / Male / Mitogen-Activated Protein Kinases / Nerve Crush / Nerve Regeneration / Peripheral Nerve Injuries / Peripheral Nerves / Proto-Oncogene Proteins c-akt / Rats / Rats, Sprague-Dawley / Receptors, Platelet-Derived Growth Factor / Sciatic Nerve / シグナル伝達 (signal transduction)
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1529-8027.2009.00228.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19909480; ● Search Scopus @ Elsevier (PMID): 19909480; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1529-8027.2009.00228.x

(DOI: 10.1111/j.1529-8027.2009.00228.x, PubMed: 19909480) Shiho Fujisaka, Isao Usui, Agussalim Bukhari, Masashi Ikutani, Takeshi Oya, Yukiko Kanatani, Koichi Tsuneyama, Yoshinori Nagai, Kiyoshi Takatsu, Masaharu Urakaze, Masashi Kobayashi and Kazuyuki Tobe :
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.,
Diabetes, Vol.58, No.11, 2574-2582, 2009.

(要約): M1 and M2 ATMs constitute different subsets of macrophages. Insulin resistance is associated with both the number of M1 macrophages and the M1-to-M2 ratio. The increased expression of IL-10 after an HFD might be involved in the increased recruitment of M2 macrophages.
(キーワード): Adenoviridae / Adipocytes / Adipose Tissue / Animals / Dietary Fats / Epididymis / Flow Cytometry / 遺伝子発現 (gene expression) / Genetic Vectors / 生体恒常性 (homeostasis) / Hypoglycemic Agents / Immunohistochemistry / Interleukin-10 / Macrophages / Male / Mice / Mice, Inbred C57BL / Mice, Obese / 肥満症 (obesity) / Pioglitazone / RNA (RNA) / Reverse Transcriptase Polymerase Chain Reaction / Stromal Cells / Thiazolidinediones
(出版サイトへのリンク): ● Publication site (DOI): 10.2337/db08-1475
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19690061; ● Search Scopus @ Elsevier (PMID): 19690061; ● Search Scopus @ Elsevier (DOI): 10.2337/db08-1475

(DOI: 10.2337/db08-1475, PubMed: 19690061) Hiroshi Kudo, Yutaka Yata, Terumi Takahara, Kengo Kawai, Yasuhiro Nakayama, Masami Kanayama, Takeshi Oya, Seiichi Morita, Masakiyo Sasahara, A Derek Mann and Toshiro Sugiyama :
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.,
Liver International, Vol.29, No.7, 988-996, 2009.

(要約): In this study, we revealed that Tel attenuated steatohepatitis progression by suppressing the macrophage infiltration into the liver. Tel also affected the reduction of adipocyte size and elevation of serum adiponectin. Tel might serve as a new therapeutic strategy for NASH.
(キーワード): Adipocytes / Adiponectin / Angiotensin II Type 1 Receptor Blockers / Animals / Benzimidazoles / Benzoates / 血圧 (blood pressure) / Cell Line / Cell Size / Chemokine CCL2 / Choline Deficiency / Collagen Type I / Disease Models, Animal / Disease Progression / Drinking / Eating / Fatty Liver / Intra-Abdominal Fat / Liver / Liver Cirrhosis / Macrophages / Male / Methionine / Mice / Mice, Inbred C57BL / Organ Size / 酸化ストレス (oxidative stress) / RNA, Messenger / Receptors, CCR2 / Telmisartan / Transforming Growth Factor beta1 / Triglycerides
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1478-3231.2009.02006.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19386026; ● Search Scopus @ Elsevier (PMID): 19386026; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1478-3231.2009.02006.x

(DOI: 10.1111/j.1478-3231.2009.02006.x, PubMed: 19386026) Yasuhito Yahara, Yoshiharu Kawaguchi, Shoji Seki, Yumiko Abe, Takeshi Oya and Tomoatsu Kimura :
Ligamentum flavum cyst of the cervical spine associated with rheumatoid arthritis.,
Journal of Orthopaedic Science, Vol.14, No.2, 215-218, 2009.

(キーワード): Arthritis, Rheumatoid / Bone Screws / Cervical Vertebrae / Cysts / Female / Humans / Ligamentum Flavum / Middle Aged / Paresthesia / Spinal Fusion
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00776-008-1313-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19337815; ● Search Scopus @ Elsevier (PMID): 19337815; ● Search Scopus @ Elsevier (DOI): 10.1007/s00776-008-1313-8

(DOI: 10.1007/s00776-008-1313-8, PubMed: 19337815) Taketoshi Yasuda, Masahiko Kanamori, Shigeharu Nogami, Takeshi Hori, Takeshi Oya, Kayo Suzuki and Tomoatsu Kimura :
Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization.,
Journal of Experimental & Clinical Cancer Research, Vol.28, 2009.

(要約): The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcoma cell line, UTOS-1, from a typical osteoblastic OS of an 18-year-old man. Cultured UTOS-1 cells are spindle-shaped, and have been maintained in vitro for over 50 passages in more than 2 years. Xenografted UTOS-1 cells exhibit features typical of OS, such as production of osteoid or immature bone matrix, and proliferation potency in vivo. UTOS-1 also exhibit morphological and immunohistochemical characteristics typical of osteoblastic OS. Chromosomal analysis by G-band show 73~85 chromosomes with complicated translocations. Array CGH show frequent gains at locus DAB2 at chromosome 5q13, CCND2 at 12p13, MDM2 at 12q14.3-q15, FLI and TOP3A at 17p11.2-p12 and OCRL1 at Xq25, and show frequent losses at HTR1B at 6q13, D6S268 at 6q16.3-q21, SHGC17327 at 18ptel, and STK6 at 20q13.2-q13.3. The UTOS-1 cell line may prove useful for biologic and molecular pathogenetic investigations of human OS.
(キーワード): Adolescent / Animals / Bone Neoplasms / Cell Line, Tumor / Cytogenetic Analysis / DNA Primers / Humans / 免疫組織化学 (immunohistochemistry) / Male / Mice / Mice, SCID / Microscopy, Phase-Contrast / Neoplasm Transplantation / Nucleic Acid Hybridization / Osteosarcoma / Polymerase Chain Reaction
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1756-9966-28-26
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19239720; ● Search Scopus @ Elsevier (PMID): 19239720; ● Search Scopus @ Elsevier (DOI): 10.1186/1756-9966-28-26

(DOI: 10.1186/1756-9966-28-26, PubMed: 19239720) 濱島丈, 尾矢剛志, 石井陽子, 申杰, 石澤伸, 笹原正清 :
皮下嚢胞として発症した類血管腫型線維性組織球腫の1例,
診断病理 : Japanese journal of diagnostic pathology, Vol.26, No.1, 62-67, 2009年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573950400481942144

(CiNii: 1573950400481942144) Tomoko Watanabe, Takuto Fujii, Takeshi Oya, Naoki Horikawa, Yoshiaki Tabuchi, Yuji Takahashi, Magotoshi Morii, Noriaki Takeguchi, Kazuhiro Tsukada and Hideki Sakai :
Involvement of aquaporin-5 in differentiation of human gastric cancer cells.,
The Journal of Physiological Sciences, Vol.59, No.2, 113-122, 2009.

(要約): Litttle is known about the function of aquaporin (AQP) water channels in human gastric cancer. In the upper or middle part of human stomach, we found that expression level of AQP5 protein in intestinal type of adenocarcinoma was significantly higher than that in accompanying normal mucosa. AQP5 was localized in the apical membrane of the cancer cells. On the other hand, both AQP3 and AQP4 were not up-regulated in the adenocarcinoma. To elucidate the role of AQP5 in cancer cells, AQP5 was exogenously expressed in a cell line of poorly differentiated human gastric adenocarcinoma (MKN45). The AQP5 expression significantly increased the proportion of differentiated cells with a spindle shape, the activity of alkaline phosphatase, a marker for the intestinal epithelial cell type of cancer cells, and the expression level of laminin, an epithelial cell marker. Treatment of the MKN45 cells stably expressing AQP5 with HgCl(2), an inhibitor of aquaporins, significantly decreased the proportion of differentiated cells and the activity of alkaline phosphatase. Our results suggest that up-regulation of AQP5 may be involved in differentiation of human gastric cancer cells.
(キーワード): Adenocarcinoma / Aged / Aged, 80 and over / Alkaline Phosphatase / Aquaporin 5 / Biomarkers / 細胞分化 (cell differentiation) / Cell Line, Tumor / Female / Humans / Laminin / Male / Mercuric Chloride / Middle Aged / Stomach Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12576-008-0017-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19340551; ● Search Scopus @ Elsevier (PMID): 19340551; ● Search Scopus @ Elsevier (DOI): 10.1007/s12576-008-0017-3

(DOI: 10.1007/s12576-008-0017-3, PubMed: 19340551) Hikari Suzuki, Ichiro Kato, Isao Usui, Ichiro Takasaki, Yoshiaki Tabuchi, Takeshi Oya, Koichi Tsuneyama, Hiroshi Kawaguchi, Koichi Hiraga, Shin Takasawa, Hiroshi Okamoto, Kazuyuki Tobe and Masakiyo Sasahara :
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.,
Biochemical and Biophysical Research Communications, Vol.379, No.1, 38-42, 2008.

(要約): Detailed studies were performed on diabetic kidneys derived from transgenic mice overexpressing the mutant form (Thr286Asp) of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaM kinase IIalpha) in pancreatic beta-cells. Kidney weight/body weight ratio, urinary albumin/creatinine ratio, serum BUN level, and mesangial/glomerular area ratio were all significantly higher in transgenic mice than in wild-type mice. cDNA microarray analysis revealed 17 up-regulated genes and 12 down-regulated genes in transgenic kidney. Among up-regulated genes, cyclin D2 (6.70-fold) and osteopontin (2.35-fold) were thought to play important roles in the progression of diabetic nephropathy. Transgenic glomeruli and tubular epithelial cells were strongly stained for osteopontin, a molecule which induces immune response. In quantitative real-time RT-PCR analyses, expressions of not only M1 macrophage marker genes but also M2 macrophage marker genes were elevated in renal cortex of transgenic mice. Overall results indicate that CaM kinase IIalpha (Thr286Asp) transgenic mice serve as an excellent model for diabetic nephropathy.
(キーワード): Amino Acid Substitution / Animals / Antigens, Differentiation / Aspartic Acid / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Diabetic Nephropathies / Disease Models, Animal / Kidney / Macrophages / Male / Mice / Mice, Transgenic / Oligonucleotide Array Sequence Analysis / オステオポンティン (osteopontin) / RNA, Messenger / Threonine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.bbrc.2008.11.143
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19070598; ● Search Scopus @ Elsevier (PMID): 19070598; ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2008.11.143

(DOI: 10.1016/j.bbrc.2008.11.143, PubMed: 19070598) Ichiro Kato, Takeshi Oya, Hikari Suzuki, Kumi Takasawa, M Andi Ichsan, Shinji Nakada, Yoko Ishii, Yutaka Shimada, Masakiyo Sasahara, Kazuyuki Tobe, Shin Takasawa, Hiroshi Okamoto and Koichi Hiraga :
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.,
Diabetes/Metabolism Research and Reviews, Vol.24, No.6, 486-497, 2008.

(要約): The TG mice established herein will be valuable as a novel model of severe insulin-dependent diabetes accompanied by an early progression of diabetic micro-vascular complications.
(キーワード): Amino Acid Substitution / Animals / Animals, Genetically Modified / Aspartic Acid / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / DNA Primers / Diabetes Mellitus, Type 1 / Diabetic Angiopathies / Diabetic Nephropathies / Disease Models, Animal / Disease Progression / Female / Insulin-Secreting Cells / Mice / Mice, Inbred Strains / Threonine
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/dmrr.864
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18551708; ● Search Scopus @ Elsevier (PMID): 18551708; ● Search Scopus @ Elsevier (DOI): 10.1002/dmrr.864

(DOI: 10.1002/dmrr.864, PubMed: 18551708) Ayano Tokunaga, Takeshi Oya, Yoko Ishii, Hiraku Motomura, Chieko Nakamura, Shin Ishizawa, Toshihiko Fujimori, Yo-Ichi Nabeshima, Akihiro Umezawa, Masahiko Kanamori, Tomoatsu Kimura and Masakiyo Sasahara :
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.,
Journal of Bone and Mineral Research, Vol.23, No.9, 1519-1528, 2008.

(要約): Mesenchymal stromal cells (MSCs) in bone marrow are important for bone homeostasis. Although platelet-derived growth factor (PDGF) has been reported to be involved in osteogenic differentiation of MSCs, the role remains controversial and the network of PDGF signaling for MSCs has not been clarified. To clarify the underlying regulatory mechanism of MSC functions mediated by PDGF, we deleted the PDGF receptor (PDGFR)beta gene by Cre-loxP strategy and examined the role of PDGF in osteogenic differentiation of MSCs and fracture repair. In cultured MSCs, the mRNA expression of PDGF-A, -B, -C, and -D as well as PDGFRalpha and beta was detected. Depletion of PDGFRbeta in MSCs decreased the mitogenic and migratory responses and enhanced osteogenic differentiation as evaluated by increased alkaline phosphatase (ALP) activity and mRNA levels of ALP, osteocalcin (OCN), bone morphogenetic protein (BMP) 2, Runx2, and osterix in quantitative RT-PCR. PDGF-BB, but not PDGF-AA, inhibited osteogenic differentiation accompanied by decreased ALP activity and mRNA levels, except for BMP2. These effects of PDGF-BB were eliminated by depletion of PDGFRbeta in MSCs except that PDGF-BB still suppressed osterix expression in PDGFRbeta-depleted MSCs. Depletion of PDGFRbeta significantly increased the ratio of woven bone to callus after fracture. From the combined analyses of PDGF stimulation and specific PDGFRbeta gene deletion, we showed that PDGFRbeta signaling distinctively induces proliferative and migratory responses but strongly inhibits osteogenic differentiation of MSCs. The effects of PDGFRalpha on the osteogenic differentiation were very subtle. PDGFRbeta could represent an important target for guided tissue regeneration or tissue engineering of bone.
(キーワード): Alkaline Phosphatase / Animals / Bone Marrow Cells / 細胞分化 (cell differentiation) / 細胞増殖·分化 (cell proliferation and differentiation) / Fractures, Bone / Gene Deletion / Gene Expression Regulation / Mesoderm / Mice / Osteocalcin / Osteogenesis / Platelet-Derived Growth Factor / RNA, Messenger / Receptor, Platelet-Derived Growth Factor alpha / Receptor, Platelet-Derived Growth Factor beta / Reproducibility of Results / Reverse Transcriptase Polymerase Chain Reaction / Stromal Cells / Transcription Factors / Wound Healing
(出版サイトへのリンク): ● Publication site (DOI): 10.1359/jbmr.080409
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18410236; ● Search Scopus @ Elsevier (PMID): 18410236; ● Search Scopus @ Elsevier (DOI): 10.1359/jbmr.080409

(DOI: 10.1359/jbmr.080409, PubMed: 18410236) Syota Kagawa, Yoshiyuki Soeda, Hajime Ishihara, Takeshi Oya, Masakiyo Sasahara, Saori Yaguchi, Ryo Oshita, Tsutomu Wada, Hiroshi Tsuneki and Toshiyasu Sasaoka :
Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.,
Endocrinology, Vol.149, No.2, 642-650, 2007.

(要約): SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in peripheral tissues of diabetic C57BL/KSJ-db/db mice. To clarify the impact of SHIP2 in the pathogenesis of insulin resistance with type 2 diabetes, we generated transgenic mice overexpressing SHIP2. The body weight of transgenic mice increased by 5.0% (P < 0.05) compared with control wild-type littermates on a normal chow diet, but not on a high-fat diet. Glucose tolerance and insulin sensitivity were mildly but significantly impaired in the transgenic mice only when maintained on the normal chow diet, as shown by 1.2-fold increase in glucose area under the curve over control levels at 9 months old. Insulin-induced phosphorylation of Akt was decreased in the SHIP2-overexpressing fat, skeletal muscle, and liver. In addition, the expression of hepatic mRNAs for glucose-6-phosphatase and phosphoenolpyruvate carboxykinase was increased, that for sterol regulatory element-binding protein 1 was unchanged, and that for glucokinase was decreased. Consistently, hepatic glycogen content was reduced in the 9-month-old transgenic mice. Structure and insulin content were histologically normal in the pancreatic islets of transgenic mice. These results indicate that increased abundance of SHIP2 in vivo contributes, at least in part, to the impairment of glucose metabolism and insulin sensitivity on a normal chow diet, possibly by attenuating peripheral insulin signaling and by altering hepatic gene expression for glucose homeostasis.
(キーワード): Adipocytes / Animals / Blood Glucose / Body Weight / エネルギー代謝 (energy metabolism) / Female / グリコーゲン (glycogen) / 生体恒常性 (homeostasis) / Inositol Polyphosphate 5-Phosphatases / インスリン (insulin) / Ion Channels / Lipogenesis / Liver / Male / Mice / Mice, Inbred C57BL / Mice, Transgenic / Mitochondrial Proteins / Pancreas / Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases / Phosphoric Monoester Hydrolases / RNA, Messenger / シグナル伝達 (signal transduction) / Transgenes / Uncoupling Protein 1 / Uncoupling Protein 2 / Uncoupling Protein 3
(出版サイトへのリンク): ● Publication site (DOI): 10.1210/en.2007-0820
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18039790; ● Search Scopus @ Elsevier (PMID): 18039790; ● Search Scopus @ Elsevier (DOI): 10.1210/en.2007-0820

(DOI: 10.1210/en.2007-0820, PubMed: 18039790) Futoshi Mio, Kazuhiro Chiba, Yuichiro Hirose, Yoshiharu Kawaguchi, Yasuo Mikami, Takeshi Oya, Masaki Mori, Michihiro Kamata, Morio Matsumoto, Kouichi Ozaki, Toshihiro Tanaka, Atsushi Takahashi, Toshikazu Kubo, Tomoatsu Kimura, Yoshiaki Toyama and Shiro Ikegawa :
A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation.,
American Journal of Human Genetics, Vol.81, No.6, 1271-1277, 2007.

(要約): Lumbar disc herniation (LDH), degeneration and herniation of the nucleus pulposus of the intervertebral disc (IVD) of the lumbar spine, is one of the most common musculoskeletal diseases. Its etiology and pathogenesis, however, remain unclear. Type XI collagen is important for cartilage collagen formation and for organization of the extracellular matrix. We identified an association between one of the type XI collagen genes, COL11A1, and LDH in Japanese populations. COL11A1, which encodes the alpha 1 chain of type XI collagen, was highly expressed in IVD, but its expression was decreased in the IVD of patients with LDH. The expression level was inversely correlated with the severity of disc degeneration. A single-nucleotide polymorphism (c.4603C-->T [rs1676486]) had the most significant association with LDH (P=3.3 x 10(-6)), and the transcript containing the disease-associated allele was decreased because of its decreased stability. These observations indicate that type XI collagen is critical for IVD metabolism and that its decrease is related to LDH.
(キーワード): Adolescent / Adult / Aged / Autistic Disorder / Collagen Type XI / Female / Genetic Predisposition to Disease / Humans / Intervertebral Disc Displacement / 日本 (Japan) / Lumbar Vertebrae / Male / Middle Aged / Oligonucleotide Array Sequence Analysis / Polymorphism, Single Nucleotide / Reference Values / Transcription, Genetic
(出版サイトへのリンク): ● Publication site (DOI): 10.1086/522377
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17999364; ● Search Scopus @ Elsevier (PMID): 17999364; ● Search Scopus @ Elsevier (DOI): 10.1086/522377

(DOI: 10.1086/522377, PubMed: 17999364) Emiko Hori, Masanori Kurimoto, Osamu Fukuda, Chiaki Takahashi, Shoichi Nagai, Takeshi Oya and Shunro Endo :
Recurrent intracranial solitary fibrous tumor initially diagnosed as hemangiopericytoma.,
Brain Tumor Pathology, Vol.24, No.1, 31-34, 2007.

(要約): We describe a case of an intracranial solitary fibrous tumor that recurred three times consecutively in an 11-year period. A 72-year-old man presented with a headache and gait disturbance. Magnetic resonance imaging (MRI) revealed a dumbbell tumor at the left tentorium. The tumor was removed but recurred. The first diagnosis was hemangiopericytoma, but all specimens showed a "patternless pattern" and few reticulin fibers, which features were not compatible with hemangiopericytoma. All tumors showed immunoreactivity for CD34 and bcl-2. These results point to a solitary fibrous tumor (SFT) and not to hemangiopericytoma. We present here a hypercellular spindle-cell tumor that was very similar to hemangiopericytoma but is better diagnosed as SFT.
(キーワード): Aged / Aged, 80 and over / Antigens, CD34 / Brain Neoplasms / Diagnostic Errors / Hemangiopericytoma / Humans / 免疫組織化学 (immunohistochemistry) / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Mucin-1 / Neoplasm Recurrence, Local / Proto-Oncogene Proteins c-bcl-2 / Solitary Fibrous Tumors
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10014-006-0212-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18095142; ● Search Scopus @ Elsevier (PMID): 18095142; ● Search Scopus @ Elsevier (DOI): 10.1007/s10014-006-0212-y

(DOI: 10.1007/s10014-006-0212-y, PubMed: 18095142) Shinobu Kawamura, Takafumi Nakamura, Takeshi Oya, Shin Ishizawa, Yuta Sakai, Tomonori Tanaka, Shigeru Saito and Junya Fukuoka :
Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy.,
Pathology International, Vol.57, No.4, 213-218, 2007.

(要約): Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that is benign in most cases. Although SFT was first recognized to arise only in the pleura, recent reports indicate that SFT can involve a wide range of anatomical sites. To date, 17 cases of pelvic SFT have been reported. Herein is reported a case of a 74-year-old woman with a giant malignant SFT in the pelvis. Along with massive invasion to adjacent organs and multiple lung metastases detected on radiography, biopsy from the tumor through the vaginal wall showed malignant looking spindle-cell neoplasm with increased cellularity, areas of necrosis, and high mitotic activity (5/10 high-power fields). Immunohistochemically, the tumor cells were diffusely and strongly positive for CD34, CD99, and bcl-2. Based on pathological features and clinical presentation, diagnosis of malignant SFT was made. The patient received systemic and the intra-arterial chemotherapy followed by whole pelvic radiation therapy (50 Gy). Initial chemotherapies failed to control the tumor. Afterwards, improvement was observed radiologically and pathologically in the 12 months' follow up after the radiation therapy. This is the first report related to therapeutic remarks on advanced malignant SFT.
(キーワード): Aged / Carcinoma / Disease Progression / Female / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Neoplasm Metastasis / Neoplasms, Fibrous Tissue / Pelvic Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1440-1827.2007.02083.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17316417; ● Search Scopus @ Elsevier (PMID): 17316417; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-1827.2007.02083.x

(DOI: 10.1111/j.1440-1827.2007.02083.x, PubMed: 17316417) Kimiko Umemura, Ichiro Kato, Yutaka Hirashima, Yoko Ishii, Takao Inoue, Junken Aoki, Nozomu Kono, Takeshi Oya, Nakamasa Hayashi, Hideo Hamada, Shunro Endo, Masaya Oda, Hiroyuki Arai, Hiroyuki Kinouchi and Koichi Hiraga :
Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.,
Stroke, Vol.38, No.3, 1063-1068, 2007.

(要約): These results indicate that PAF-AH II exerts strong neuroprotective effects against ischemic injury and suggest a possibility for clinical use of this enzyme in cerebral ischemia.
(キーワード): 1-Alkyl-2-acetylglycerophosphocholine Esterase / Animals / Brain Ischemia / Disease Models, Animal / Female / Humans / Male / Mice / Mice, Inbred C57BL / Mice, Transgenic / Neuroprotective Agents
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/01.STR.0000257981.09329.d2
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17272759; ● Search Scopus @ Elsevier (PMID): 17272759; ● Search Scopus @ Elsevier (DOI): 10.1161/01.STR.0000257981.09329.d2

(DOI: 10.1161/01.STR.0000257981.09329.d2, PubMed: 17272759) Noriko Yamabe, Takako Yokozawa, Takeshi Oya and Mujo Kim :
Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats.,
The Journal of Pharmacology and Experimental Therapeutics, Vol.319, No.1, 228-236, 2006.

(要約): Previous investigations have demonstrated that green tea polyphenols and partially hydrolyzed guar gum as dietary fiber have antioxidative and hypolipidemic activity, respectively, supporting their reduction of risk factors in the course of diabetic nephropathy via a hypoglycemic effect and ameliorating the decline of renal function through their combined administration to rats with subtotal nephrectomy plus streptozotocin (STZ) injection. As a further study, we examined whether (-)-epigallocatechin 3-O-gallate (EGCg), the main polyphenolic compound, could ameliorate the development of diabetic nephropathy. Rats with subtotal nephrectomy plus STZ injection were orally administrated EGCg at doses of 25, 50, and 100 mg/kg body weight/day. After a 50-day administration period, EGCg-treated groups showed suppressed hyperglycemia, proteinuria, and lipid peroxidation, although there were only weak effects on the levels of serum creatinine and glycosylated protein. Furthermore, EGCg reduced renal advanced glycation end-product accumulation and its related protein expression in the kidney cortex as well as associated pathological conditions. These results suggest that EGCg ameliorates glucose toxicity and renal injury, thus alleviating renal damage caused by abnormal glucose metabolism-associated oxidative stress involved in renal lesions of diabetic nephropathy.
(キーワード): Animals / Body Weight / カテキン (catechin) / Cyclooxygenase 2 / Diabetic Nephropathies / Fibronectins / Kidney / Male / NF-kappa B / Nitric Oxide Synthase Type II / Organ Size / Proteinuria / Rats / Rats, Wistar / Receptor for Advanced Glycation End Products / Receptors, Immunologic / Transforming Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.1124/jpet.106.107029
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16835369; ● Search Scopus @ Elsevier (PMID): 16835369; ● Search Scopus @ Elsevier (DOI): 10.1124/jpet.106.107029

(DOI: 10.1124/jpet.106.107029, PubMed: 16835369) Chunmei Cheng, Koichi Tsuneyama, Huachuan Zheng, Takeshi Oya, Zhengguo Cui, B Loreto Feril and Yasuo Takano :
Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism.,
Pathology, Research and Practice, Vol.202, No.8, 591-598, 2006.

(要約): Cholesterol crystal embolism (CCE) is a systemic refractory disease especially prevalent amongst elderly patients suffering from atherosclerosis. Treatment of this condition remains controversial due to difficulties in diagnosis. Corticosteroid therapy may be an important treatment option despite its elusive mechanisms. To clarify the role of corticosteroid in CCE therapy, we collected the samples from six autopsied subjects with CCE, three of whom were clinically given various doses of corticosteroid to investigate stable atherosclerosis-related substances, advanced glycation end-products (AGE), and several AGE receptors such as scavenger receptor class B type 1 (SR-B1), receptor for AGE (RAGE), and galectin-3 in the liver tissues and atherosclerotic areas by immunostaining using a tissue macro-array technique. An intense expression of AGE and its receptors was identified in the enlarged Kupffer cells of CCE cases, which were given relatively high doses of corticosteroid. In addition, numerous mononuclear cells in the intimal atheromatous plaque presented strong expressions of AGE and SR-B1. In conclusion, we speculated that corticosteroid treatment for CCE may upregulate the activations, including phagocytic capacity of Kupffer cells mediated by overexpression of RAGE and scavenger receptors, resulting in efficient clearance of the lipid substances from the blood circulation released from atherosclerotic areas.
(キーワード): Aged / Aged, 80 and over / コレステロール (cholesterol) / Embolism, Cholesterol / Female / Fluorescent Antibody Technique, Indirect / Glucocorticoids / Glycation End Products, Advanced / Humans / Immunoenzyme Techniques / Liver / Male / Scavenger Receptors, Class B
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.prp.2006.04.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16814943; ● Search Scopus @ Elsevier (PMID): 16814943; ● Search Scopus @ Elsevier (DOI): 10.1016/j.prp.2006.04.005

(DOI: 10.1016/j.prp.2006.04.005, PubMed: 16814943) Yoko Ishii, Takeshi Oya, Lianshun Zheng, Zhiyang Gao, Makoto Kawaguchi, Hemragul Sabit, Takako Matsushima, Ayano Tokunaga, Shin Ishizawa, Etsuro Hori, Yo-ichi Nabeshima, Toshikuni Sasaoka, Toshihiko Fujimori, Hisashi Mori and Masakiyo Sasahara :
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.,
Journal of Neurochemistry, Vol.98, No.2, 588-600, 2006.

(要約): Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are widely expressed in the mammalian CNS, though their functional significance remains unclear. The corresponding null-knockout mutations are lethal. Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in the post-natal stage. Our mutant mice reached adulthood without apparent anatomical defects. In the mutant brain, immunohistochemical analyses showed that PDGFR-beta detected in neurons and in the cells in the subventricular zone of the lateral ventricle in wild-type mice was depleted, but PDGFR-beta detected in blood vessels remained unaffected. The cerebral damage after cryogenic injury was severely exacerbated in the mutants compared with controls. Furthermore, TdT-mediated dUTP-biotin nick end labeling (TUNEL)-positive neuronal cell death and lesion formation in the cerebral hemisphere were extensively exacerbated in our mutant mice after direct injection of NMDA without altered NMDA receptor expression. Our results clearly demonstrate that PDGFR-beta expressed in neurons protects them from cryogenic injury and NMDA-induced excitotoxicity.
(キーワード): Animals / Blotting, Western / 脳 (brain) / Brain Chemistry / Brain Damage, Chronic / DNA Primers / Freezing / 免疫組織化学 (immunohistochemistry) / In Situ Nick-End Labeling / Intermediate Filament Proteins / Mice / ノックアウトマウス (knockout mice) / Mutation / N-Methylaspartate / Nerve Tissue Proteins / Nestin / Neurons / Promoter Regions, Genetic / Receptor, Platelet-Derived Growth Factor beta / Reverse Transcriptase Polymerase Chain Reaction
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/j.1471-4159.2006.03922.x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16805849; ● Search Scopus @ Elsevier (PMID): 16805849; ● Search Scopus @ Elsevier (DOI): 10.1111/j.1471-4159.2006.03922.x

(DOI: 10.1111/j.1471-4159.2006.03922.x, PubMed: 16805849) 津田基晴, 一木克之, 土岐善紀, 薄田勝男, 三崎拓郎, 荒井信貴, 清水正司, 尾矢剛志 :
甲状腺癌手術後15年に発見された縦隔リンパ節転移の1例,
胸部外科, Vol.59, No.6, 487-490, 2006年.

(キーワード): thyroid cancer / mediastinal lymph node metastasis
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238029404416

(CiNii: 1390564238029404416) Yoshiharu Kawaguchi, Takeshi Oya, Yumiko Abe, Masahiko Kanamori, Hirokazu Ishihara, Taketoshi Yasuda, Shigeharu Nogami, Takeshi Hori and Tomoatsu Kimura :
Spinal stenosis due to ossified lumbar lesions.,
Journal of Neurosurgery. Spine, Vol.3, No.4, 262-270, 2005.

(要約): Because coexisting ossified lesions were frequently seen, whole-spine analysis is recommended. Early diagnosis and appropriate treatment are important to achieve a better surgical outcome.
(キーワード): Adult / Age Factors / Aged / Body Mass Index / Diabetes Complications / Female / Humans / Longitudinal Ligaments / Lumbar Vertebrae / Male / Middle Aged / 肥満症 (obesity) / Ossification, Heterotopic / Retrospective Studies / Sex Factors / Spinal Stenosis / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/spi.2005.3.4.0262
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16266066; ● Search Scopus @ Elsevier (PMID): 16266066; ● Search Scopus @ Elsevier (DOI): 10.3171/spi.2005.3.4.0262

(DOI: 10.3171/spi.2005.3.4.0262, PubMed: 16266066) Takako Yokozawa, Takako Nakagawa, Takeshi Oya, Tsutomu Okubo and Raj Lekh Juneja :
Green tea polyphenols and dietary fibre protect against kidney damage in rats with diabetic nephropathy.,
The Journal of Pharmacy and Pharmacology, Vol.57, No.6, 773-780, 2005.

(要約): In this study we examined the effect of green tea polyphenols (GTP) and partially hydrolysed guar gum (PHGG) as dietary fibre on diabetic nephropathy, using rats that had been subjected to subtotal nephrectomy and injection of streptozotocin. The subtotally nephrectomized rats were subjected to resection of three-quarters of the kidney. Rats with diabetic nephropathy were divided into four groups: untreated controls, and animals that received GTP (100 mg kg-1 body weight day-1), PHGG (100 mg kg-1 body weight day-1) and GTP plus PHGG (50 mg kg-1 body weight day-1 plus 50 mg kg-1 body weight day-1). After 50 days of administration, attenuation of urinary protein excretion and the morphological changes peculiar to diabetic nephropathy were observed in all three treated groups. Furthermore, the group treated with GTP plus PHGG showed an improvement of kidney weight and serum levels of urea nitrogen, creatinine and creatinine clearance. Hyperglycaemia, as assessed in terms of blood glucose and glycosylated protein levels, was also improved by administration of GTP plus PHGG. On the other hand, GTP administration increased the activity of superoxide dismutase in the kidney to a significant extent. A significant reduction in the total cholesterol concentration was also observed in the PHGG-treated group. These results suggest that GTP and PHGG could be beneficial as additional therapy in the management of diabetic nephropathy.
(キーワード): Animals / Blood Glucose / コレステロール (cholesterol) / Diabetic Nephropathies / Dietary Fiber / フラボノイド (flavonoids) / Galactans / 腎疾患 (kidney disease) / Kidney Function Tests / Male / Malondialdehyde / Mannans / Organ Size / Phenols / Plant Gums / Polyphenols / Rats / Rats, Wistar / Superoxide Dismutase / Tea
(出版サイトへのリンク): ● Publication site (DOI): 10.1211/0022357056154
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15969933; ● Search Scopus @ Elsevier (PMID): 15969933; ● Search Scopus @ Elsevier (DOI): 10.1211/0022357056154

(DOI: 10.1211/0022357056154, PubMed: 15969933) Shoji Seki, Yoshiharu Kawaguchi, Kazuhiro Chiba, Yasuo Mikami, Hideki Kizawa, Takeshi Oya, Futoshi Mio, Masaki Mori, Yoshinari Miyamoto, Ikuko Masuda, Tatsuhiko Tsunoda, Michihiro Kamata, Toshikazu Kubo, Yoshiaki Toyama, Tomoatsu Kimura, Yusuke Nakamura and Shiro Ikegawa :
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.,
Nature Genetics, Vol.37, No.6, 607-612, 2005.

(キーワード): Adolescent / Adult / Aged / Case-Control Studies / Chromosomes, Human, Pair 15 / Disease Susceptibility / Extracellular Matrix Proteins / Female / Humans / Intervertebral Disc Displacement / Lumbar Vertebrae / Male / Middle Aged / Polymorphism, Single Nucleotide / Pyrophosphatases / シグナル伝達 (signal transduction) / Transforming Growth Factor beta
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/ng1557
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15864306; ● Search Scopus @ Elsevier (PMID): 15864306; ● Search Scopus @ Elsevier (DOI): 10.1038/ng1557

(DOI: 10.1038/ng1557, PubMed: 15864306) Tatsuhiko Kashii, Tomoharu Gomi, Takeshi Oya, Yoko Ishii, Hirofumi Oda, Muneharu Maruyama, Masashi Kobayashi, Tohru Masuda, Mitsuaki Yamazaki, Takuya Nagata, Kazuhiro Tsukada, Akinori Nakajima, Kazuhito Tatsu, Hisashi Mori, Fusao Takusagawa, Hirofumi Ogawa and C Henry Pitot :
Some biochemical and histochemical properties of human liver serine dehydratase.,
The International Journal of Biochemistry & Cell Biology, Vol.37, No.3, 574-589, 2005.

(キーワード): Amino Acid Sequence / Animals / Base Sequence / Blotting, Western / Chromatography, Gel / Chromatography, Ion Exchange / Electrophoresis, Polyacrylamide Gel / 大腸菌 (Escherichia coli) / Humans / 免疫組織化学 (immunohistochemistry) / Kinetics / L-Serine Dehydratase / Liver / Male / Molecular Sequence Data / Peptide Hydrolases / Proteins / Rats / Rats, Wistar / Recombinant Proteins / Sequence Homology, Amino Acid / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Spectrophotometry / トリプシン (trypsin)
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.biocel.2004.08.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15618015; ● Search Scopus @ Elsevier (PMID): 15618015; ● Search Scopus @ Elsevier (DOI): 10.1016/j.biocel.2004.08.004

(DOI: 10.1016/j.biocel.2004.08.004, PubMed: 15618015) Shigeharu Nogami, Yoko Ishii, Makoto Kawaguchi, Nobuo Sakata, Takeshi Oya, Kiyoshi Takagawa, Masahiko Kanamori, Toshiyuki Obata, Tomoatsu Kimura and Masakiyo Sasahara :
ZFH-4 protein is expressed in many neurons of developing rat brain.,
The Journal of Comparative Neurology, Vol.482, No.1, 33-49, 2005.

(要約): The zinc finger-homeodomain (ZFH) transcription factors contain a zinc finger motif and a homeodomain that might regulate neural and mesenchymal cell differentiation. We have cloned the ZFH4 gene that encodes a protein with structures closely related to ATBF1. In order to study the expression pattern of ZFH4 in the developing rat brain, we raised an antibody against a glutathione-S-transferase (GST) fusion protein of ZFH4. Western blotting with this antibody identified a gene product of 390 kDa in the normal rat brain. Levels of the protein were high in the brainstem at embryonic and neonatal periods and in the midbrain and diencephalon in neonatal rat brain. In addition, the corresponding mRNA of 12.5 kb was detected by Northern blotting. An immunolocalization study showed that postmitotic neurons in the brainstem were the major site of ZFH4 expression, and the levels of expression varied depending on age and anatomical sites. Expression was transient and weak in precursor cells at early neurogenesis. Although ZFH4 levels decreased after birth, ZFH4 continued to be expressed in the mature neurons including DOPA decarboxylase-positive neurons. High levels of expression were also detected in non-neuronal cells of the subcommissural organ, but the expression was almost undetectable throughout precursor cells to mature neurons in the cerebral cortex and hippocampus. The spatial and temporal expression patterns closely resembled those of ATBF1, and we detected neurons that expressed ZFH4, ATBF1, or both. We postulate that ZFH4 participates in the regulation of neural cell maturation or of region-specific differentiation of the brain.
(キーワード): Animals / Blotting, Northern / Blotting, Western / 脳 (brain) / 細胞分化 (cell differentiation) / Gene Expression Regulation, Developmental / Homeodomain Proteins / 免疫組織化学 (immunohistochemistry) / Nerve Tissue Proteins / Rats / Rats, Wistar / Tissue Distribution / Transcription Factors / Zinc Fingers
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cne.20382
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15612017; ● Search Scopus @ Elsevier (PMID): 15612017; ● Search Scopus @ Elsevier (DOI): 10.1002/cne.20382

(DOI: 10.1002/cne.20382, PubMed: 15612017) Zhiyang Gao, Toshiyasu Sasaoka, Toshihiko Fujimori, Takeshi Oya, Yoko Ishii, Hemragul Sabit, Makoto Kawaguchi, Yoko Kurotaki, Maiko Naito, Tsutomu Wada, Shin Ishizawa, Masashi Kobayashi, Yo-Ichi Nabeshima and Masakiyo Sasahara :
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.,
The Journal of Biological Chemistry, Vol.280, No.10, 9375-9389, 2004.

(キーワード): Animals / DNA Primers / Fibroblasts / Gene Deletion / Genotype / Humans / Integrases / Mice / ノックアウトマウス (knockout mice) / Receptor, Platelet-Derived Growth Factor beta / Recombinant Proteins / Restriction Mapping / 皮膚 (skin) / Transfection / Wound Healing / Wounds and Injuries
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M413081200
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15590688; ● Search Scopus @ Elsevier (PMID): 15590688; ● Search Scopus @ Elsevier (DOI): 10.1074/jbc.M413081200

(DOI: 10.1074/jbc.M413081200, PubMed: 15590688) Yuichiro Oshima, Satoshi Kawaguchi, Satoshi Nagoya, Takuro Wada, Yasuo Kokai, Tatsuru Ikeda, Shigeharu Nogami, Takeshi Oya and Yasuo Hirayama :
Abdominal small round cell tumor with osteoid and EWS/FLI1.,
Human Pathology, Vol.35, No.6, 773-775, 2004.

(キーワード): 12E7 Antigen / Adult / Antigens, CD / Carcinoma, Small Cell / Cell Adhesion Molecules / Diagnosis, Differential / Humans / 免疫組織化学 (immunohistochemistry) / Male / Oncogene Proteins, Fusion / Peritoneal Neoplasms / Proto-Oncogene Protein c-fli-1 / RNA-Binding Protein EWS / Reverse Transcriptase Polymerase Chain Reaction / Transcription Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.humpath.2004.02.001
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15188147; ● Search Scopus @ Elsevier (PMID): 15188147; ● Search Scopus @ Elsevier (DOI): 10.1016/j.humpath.2004.02.001

(DOI: 10.1016/j.humpath.2004.02.001, PubMed: 15188147) Yoko Ishii, Makoto Kawaguchi, Kiyoshi Takagawa, Takeshi Oya, Shigeharu Nogami, Amane Tamura, Yutaka Miura, Akio Ido, Nobuo Sakata, Tomoko Hashimoto-Tamaoki, Tomoatsu Kimura, Takayoshi Saito, Taiki Tamaoki and Masakiyo Sasahara :
ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain.,
The Journal of Comparative Neurology, Vol.465, No.1, 57-71, 2003.

(キーワード): 老化 (aging) / Animals / Animals, Newborn / 脳 (brain) / 細胞分化 (cell differentiation) / 細胞分裂 (cell division) / Dopa Decarboxylase / Fetus / Gene Expression Regulation, Developmental / Helix-Loop-Helix Motifs / Homeodomain Proteins / 免疫組織化学 (immunohistochemistry) / Neurons / Protein Isoforms / RNA, Messenger / Rats / Rats, Wistar / Stem Cells
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cne.10807
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12926016; ● Search Scopus @ Elsevier (PMID): 12926016; ● Search Scopus @ Elsevier (DOI): 10.1002/cne.10807

(DOI: 10.1002/cne.10807, PubMed: 12926016) Ying-Luan Zhao, Kiyoshi Takagawa, Takeshi Oya, Hong-Fa Yang, Zhi-Yang Gao, Makoto Kawaguchi, Yoko Ishii, Toshiyasu Sasaoka, Koji Owada, Isao Furuta and Masakiyo Sasahara :
Active Src expression is induced after rat peripheral nerve injury.,
Glia, Vol.42, No.2, 184-193, 2003.

(キーワード): Animals / Axons / Axotomy / Cell Communication / Disease Models, Animal / Ectodysplasins / GAP-43 Protein / 免疫組織化学 (immunohistochemistry) / Male / Membrane Proteins / Nerve Crush / Nerve Regeneration / Neurofilament Proteins / Proto-Oncogene Proteins / Proto-Oncogene Proteins c-fyn / Rats / Rats, Sprague-Dawley / S100 Proteins / Schwann Cells / Sciatic Neuropathy / シグナル伝達 (signal transduction) / Up-Regulation / Wallerian Degeneration / src-Family Kinases
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/glia.10223
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12655602; ● Search Scopus @ Elsevier (PMID): 12655602; ● Search Scopus @ Elsevier (DOI): 10.1002/glia.10223

(DOI: 10.1002/glia.10223, PubMed: 12655602) Yumiko Abe, Hiroshi Nakamura, Osamu Yoshino, Takeshi Oya and Tomoatsu Kimura :
Decreased neural damage after spinal cord injury in tPA-deficient mice.,
Journal of Neurotrauma, Vol.20, No.1, 43-57, 2003.

(キーワード): Animals / アポトーシス (apoptosis) / Disease Models, Animal / Evoked Potentials, Motor / Hindlimb / Macrophages / Male / Mice / Mice, Inbred C57BL / ノックアウトマウス (knockout mice) / Microglia / Microscopy, Electron / Nerve Fibers, Myelinated / Neurons / Recovery of Function / Spinal Cord Injuries / Tissue Plasminogen Activator
(出版サイトへのリンク): ● Publication site (DOI): 10.1089/08977150360517173
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12614587; ● Search Scopus @ Elsevier (PMID): 12614587; ● Search Scopus @ Elsevier (DOI): 10.1089/08977150360517173

(DOI: 10.1089/08977150360517173, PubMed: 12614587) Takeshi Oya, Ying-Luan Zhao, Kiyoshi Takagawa, Makoto Kawaguchi, Kamon Shirakawa, Tadakazu Yamauchi and Masakiyo Sasahara :
Platelet-derived growth factor-b expression induced after rat peripheral nerve injuries.,
Glia, Vol.38, No.4, 303-312, 2002.

(キーワード): Animals / Axons / Becaplermin / Blotting, Northern / 細胞分裂 (cell division) / Gene Expression Regulation / 免疫組織化学 (immunohistochemistry) / Male / Nerve Crush / Nerve Regeneration / Peripheral Nerve Injuries / Peripheral Nerves / Platelet-Derived Growth Factor / Proliferating Cell Nuclear Antigen / Proto-Oncogene Proteins c-sis / RNA, Messenger / Rats / Rats, Sprague-Dawley / Receptor, Platelet-Derived Growth Factor beta / Schwann Cells / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/glia.10074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12007143; ● Search Scopus @ Elsevier (PMID): 12007143; ● Search Scopus @ Elsevier (DOI): 10.1002/glia.10074

(DOI: 10.1002/glia.10074, PubMed: 12007143) T Nakagawa, T Yokozawa, Takeshi Oya, M Sasahara and K Terasawa :
Evaluation of Keishi-bukuryo-gan in diabetic nephropathy model by comparing with aminoguanidine, butylated hydroxytoluene and captopril.,
Journal of Traditional Medicines, Vol.19, No.6, 200-208, 2002. M Kawaguchi, Y Miura, A Ido, T Morinaga, N Sakata, Takeshi Oya, T Hashimoto-Tamaoki, M Sasahara, F Koizumi and T Tamaoki :
DNA/RNA-dependent ATPase activity is associated with ATBF1, a multiple homeodomain-zinc finger protein.,
Biochimica et Biophysica Acta, Vol.1550, No.2, 164-174, 2001.

(キーワード): Adenosine Triphosphatases / アデノシン三リン酸 (adenosine triphosphate) / Amino Acid Sequence / Base Sequence / DNA (DNA) / DNA, Bacterial / 大腸菌 (Escherichia coli) / Homeodomain Proteins / Molecular Sequence Data / Mutagenesis, Site-Directed / Peptide Fragments / Plasmids / RNA (RNA) / Recombinant Fusion Proteins / Substrate Specificity / Zinc Fingers
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/s0167-4838(01)00284-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11755205; ● Search Scopus @ Elsevier (PMID): 11755205; ● Search Scopus @ Elsevier (DOI): 10.1016/s0167-4838(01)00284-9

(DOI: 10.1016/s0167-4838(01)00284-9, PubMed: 11755205) 小泉富美朝, 尾矢剛志, 酒井剛, 渡辺行雄 :
扁桃腺病巣敗血症の1剖検例,
口腔·咽頭科, Vol.10, No.3, 333-337, 1998年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105974570521600

(CiNii: 1573105974570521600) 酒井剛, 尾矢剛志, 小泉富美朝 :
慢性関節リウマチの滑膜組織に出現する多核巨細胞の免疫組織学的検討,
中部リウマチ, Vol.29, No.2, 79-80, 1998年. 小泉富美朝, 尾矢剛志, 酒井剛, 渡辺行雄 :
10 扁桃病巣敗血症の一剖検例,
口腔·咽頭科, Vol.10, No.1, 46, 1997年.

(出版サイトへのリンク): ● Publication site (DOI): 10.14821/stomatopharyngology1989.10.1_46
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679404904192; ● Search Scopus @ Elsevier (DOI): 10.14821/stomatopharyngology1989.10.1_46

(DOI: 10.14821/stomatopharyngology1989.10.1_46, CiNii: 1390282679404904192)

MISC

Yosuke Iwakawa, Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Mitsuo Shimada, Yasuyo Saijo, Minoru Matsumoto, Takeshi Oya and Hisanori Uehara :
Pleomorphic type undifferentiated gastric sarcoma, report of a case.,
Clinical Journal of Gastroenterology, Vol.16, No.1, 20-25, 2022.

(要約): Reports on pleomorphic type of undifferentiated sarcoma (PUS) originating from the gastrointestinal tract, especially the stomach, are extremely rare. We herein report a case of pleomorphic type undifferentiated gastric sarcoma. The patient was a 67-year-old woman. The chief complaint was upper abdominal pain. Upper gastrointestinal endoscopy, ultrasonography, and contrast-enhanced computed tomography showed two submucosal tumors at the greater curvature of the fundus and the lesser curvature of the gastric angle. Endoscopic ultrasound-guided fine-needle aspiration revealed a c-kit-negative spindle cell tumor at the greater curvature of the fundus. Total gastrectomy, splenectomy, and partial resection of the diaphragm and liver were performed. One lesion had invaded the lateral segment of the liver, left diaphragm and spleen. The postoperative course was uneventful. Histopathological and immunohistochemical examinations of the resected specimen revealed PUS. Peritoneal dissemination was detected at 8 months after surgery. However, no effective therapeutic agents were adopted for chemotherapy. The patient had poor performance status due to disease progression and underwent best supportive care. The patient died 10 months after surgery. This case highlights the imaging, histological diagnosis, and treatment strategy for PUS originating from the stomach. Surgeons should be aware of PUS as a differential diagnosis in cases with submucosal tumor of the stomach.
(キーワード): Female / Humans / Aged / Stomach Neoplasms / Gastrectomy / Sarcoma / Endoscopy, Digestive System / Liver Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12328-022-01729-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36289170; ● Search Scopus @ Elsevier (PMID): 36289170; ● Search Scopus @ Elsevier (DOI): 10.1007/s12328-022-01729-y

(DOI: 10.1007/s12328-022-01729-y, PubMed: 36289170) Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada :
Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8 tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma.,
Surgery Today, Vol.51, No.12, 1985-1995, 2021.

(要約): To clarify whether the preoperative lymphocyte/C-reactive protein (CRP) ratio (LCR) is a prognostic factor for patients with intrahepatic cholangiocarcinoma (IHCC), and investigate its mechanism via tumor-infiltrating lymphocytes. The subjects of this retrospective study were 42 patients who had undergone hepatectomy for IHCC. We divided the patients into low LCR and high LCR groups (cutoff value: 8780) and analyzed their overall survival (OS) and disease-free survival (DFS) with respect to LCR and other clinicopathological factors. We also investigated the levels of stromal tumor-infiltrating lymphocytes (TILs) and CD8 TILs in surgical specimens, and the relationship between LCR and TILs. A low LCR was identified in 21 patients and was significantly correlated with older age, a high CRP-albumin ratio, and advanced disease stage, and was a prognostic factor for OS and DFS. Multivariate analysis revealed that a low LCR was an independent prognostic factor for worse OS (HR 10.40, P = 0.0077). Although the LCR and levels of stromal TILs were not significantly related, LCR and levels of CD8 TILs were significantly related (P = 0.0297). The preoperative LCR may predict the postsurgical prognosis of patients with IHCC and reflect the CD8 TILs.
(キーワード): Bile Duct Neoplasms / Biomarkers, Tumor / C-Reactive Protein / CD8-Positive T-Lymphocytes / Cholangiocarcinoma / Female / Humans / Lymphocyte Count / Lymphocytes, Tumor-Infiltrating / Male / Predictive Value of Tests / Preoperative Period / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00595-021-02295-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34009433; ● Search Scopus @ Elsevier (PMID): 34009433; ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02295-5

(DOI: 10.1007/s00595-021-02295-5, PubMed: 34009433)

総説・解説

常山幸一, 森本友樹, 加地将真, 尾矢剛志 :
AIと分子病理学の新展開,
四国医学雑誌, Vol.76, No.1,2, 23-28, 2020年4月.

(要約): A pathological diagnosis that incorporates a molecular biology technique into a conventional pathological diagnosis based on morphology is called a molecular pathological diagnosis. Immunostaining, which detects proteins derived from oncogenes and tumor suppressor genes with specific antibodies, and FISH, which uses a fluorescently labeled nucleic acid probe to examine the amplification of a target gene, are already in clinical practice. In recent years, the application of genome analysis using a next-generation sequencer to pathological diagnosis has become available, and cancer genomic medicine has been rapidly expanding and evolving. In addition, new technologies such as liquid biopsy technology that detects proteins, DNA, microRNA, methylated DNA, etc. from samples that are less invasive at the time of collection, such as blood, are being incorporated into pathological diagnosis. The application of artificial intelligence(AI)is being studied around the world to reflect the diagnosis. This article introduces the application of rapid mass spectrometry(PESI-MS)to liquid biopsy and the development of diagnostic aids for urine cytology using AI.
(キーワード): artificial intelligence / molecular pathology / mass spectrometry / cytology / liquid biopsy
(徳島大学機関リポジトリ): ● Metadata: 114852
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050566774761704704

(徳島大学機関リポジトリ: 114852, CiNii: 1050566774761704704) 常山幸一, 松本穣, 米田亜樹子, 尾矢剛志 :
【肝細胞性腫瘍の分類・亜分類の最前線】肝細胞腺腫肝細胞腺腫の分類と分子生物学的成り立ち(解説/特集),
肝·胆·膵, Vol.80, No.4, 691-699, 2020年4月. 常山幸一, 尾矢剛志, 小川博久, 松本穣, 佐竹宣法 :
【自己免疫性肝疾患-自己免疫性肝炎，原発性胆汁性胆管炎，原発性硬化性胆管炎-】発症機序，病理自己免疫性肝炎自己免疫性肝炎の病理(解説/特集),
日本臨牀, Vol.78, No.1, 65-70, 2020年1月. 常山幸一, 清水真祐子, 尾矢剛志, 松本穣, 小林智子, 小川博久, 西辻和親, 山下理子 :
肝臓病理所見のとり方とその解釈,
法医病理, Vol.25, No.1, 1-12, 2019年7月. 尾矢剛志 :
病理診断のTurn-Around Time,
新潟県立中央病院医誌, Vol.17, No.1, 9-10, 2009年12月. 笹原正清, 石井陽子, 尾矢剛志, 濱島丈, 石澤伸 :
ヒトの心の発達とその精神病理の理解を目指して血小板由来増殖因子の情動を含む高次脳機能における役割解明へのアプローチ,
Biophilia, Vol.3, No.4, 43-48, 2007年12月. 笹原正清, 尾矢剛志, 石井陽子 :
神経組織に発現する血小板由来増殖因子 (特集脳の遺伝子--どこでどのように働いているのか),
生体の科学, Vol.56, No.4, 292-295, 2005年7月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390565159868308096

(CiNii: 1390565159868308096)

講演・発表

Makoto Funaki, Akiko Hata, Mitsuteru Yoshida, Naoki Miyamoto, Takahisa Ikuta, Yuta Uemura, MINATO AKIZUKI, Akira Tangoku, Hiromichi Yumoto, Hirohisa Ogawa and Takeshi Oya :
Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications,
Diabetes, Vol.71, No.Suppl_1, 305-OR, New Orleans, Jun. 2022. Takumi Kakimoto, Mayuko Shimizu, Koichi Tsuneyama, Minoru Matsumoto, Takeshi Oya, Hosokawa Masato and Koichi Tsuneyama :
Accumulation of α-synuclein in hepatocytes in NASH liver and usefulness in pathological diagnosis,
Digestive Disease Week 2022, May 2022. Mayuko Shimizu, Takeshi Oya and Koichi Tsuneyama :
Fibrogenesis of nonalcoholic steatohepatitis begins around cholesterol-laden macrophage in the experimental mouse model,
UEG Week 2019, Barcelona, Oct. 2019. Wenhua Shao, Yasuhiro Mouri, Takeshi Oya and Yasusei Kudo :
The role of Fat1 gene mutation in the development of maxillofacial anomalies,
第113回日本病理学会総会, Mar. 2024. 西條康代, 常山幸一, 松本穣, 尾矢剛志 :
悪性転化を来した biliary adenofibroma の1例,
第113回日本病理学会総会, 2024年3月. 卲文華, 毛利安宏, 尾矢剛志, 工藤保誠 :
The novel function of Fat1 gene mutation in the development of maxillofacial anomalies,
第129回日本解剖学会総会・全国学術集会, 2024年3月. 松澤鎮史, 常松貴明, 永尾瑠佳, 大塚邦紘, 牛尾綾, 尾矢剛志, 石丸直澄 :
歯肉腫瘍,
日本病理学会中国四国支部学術集会(第143回スライドカンファレンス), 2024年2月. 松本穣, 西條康代, 尾矢剛志 :
S2900,
日本病理学会中国四国支部学術集会(Web開催)第142回スライドカンファレンス, 2023年11月. 行重佐和香, 井上寛章, 乾友浩, 笹聡一郎, 青山万理子, 尾矢剛志, 坂東良美, 後藤正和, 滝沢宏光 :
乳腺原発神経内分泌腫瘍の1例,
第33回日本乳癌検診学会学術総会, 2023年11月. 松本力三, 西尾進, 森田沙瑛, 湯浅麻美, 平田有紀奈, 齋藤裕, 友成哲, 尾矢剛志, 坂東良美, 佐田政隆 :
術前診断が困難であった肝臓原発リンパ管腫の1例,
第33回日本超音波産学会四国地方会学術集会, 2023年10月. 巨島弘基, 谷口拓也, 河原田理愛, 尾矢剛志, 常山幸一, 大野将樹, 獅々堀正幹 :
細胞診断システムにおける円形度に着目した領域分割の改善,
2023年電気学会電子・情報・システム部門大会, PS1-10, 2023年8月. 西條康代, 尾矢剛志, 松本穣 :
S2883 下垂体腫瘍,
日本病理学会中国四国支部学術集会(Web開催)第141回スライドカンファレンス, 2023年6月. 船木真理, 秦明子, 吉田光輝, 宮本直輝, 生田貴久, 植村勇太, 秋月皆人, 丹黒章, 湯本浩通, 小川博久, 尾矢剛志 :
休眠状態の脂肪組織由来間葉系幹細胞による細胞老化随伴分泌現象の解除と糖尿病性合併症治療への応用の可能性,
糖尿病, Vol.66, No.Suppl.1, S.246, 2023年5月. 高橋雅子, 何森亜由美, 廣瀬千恵子, 尾矢剛志, 笹三徳 :
穿刺吸引細胞診後に針生検を施行した症例の検討,
第30回日本乳癌学会学術総会, PageEP3-55, 2022年7月. 船木真理, 吉田光輝, 宮本直輝, 生田貴久, 植村勇太, 秋月皆人, 秦明子, 丹黒章, 湯本浩通, 小川博久, 尾矢剛志 :
休眠状態の導入・維持による脂肪組織由来間葉系幹細胞の若返りを通じた，糖尿病性合併症治療への応用の可能性,
糖尿病, Vol.65, No.Suppl.1, S257, 2022年5月. 松本穣, 西條康代, 清水真祐子, 小川博久, 常山幸一, 松本満, 尾矢剛志 :
胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性,
日本病理学会会誌, Vol.111, No.1, 243, 2022年4月. 吉田光輝, 近藤和也, 北市隆, 西庄俊彦, 出水祐介, 尾矢剛志, 宮本直輝, 川上行奎, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 滝沢宏光 :
浸潤性縦隔腫瘍にいかに立ち向かうか-希少腫瘍の治療への挑戦-,
第122回日本外科学会定期学術集会(ハイブリッド開催), 2022年4月. 正田真由美, 大久保律子, 高橋雅子, 笹聡一郎, 小川博久, 尾矢剛志 :
Collagenous spherulosisが目立った乳腺病変の1例,
令和3年度徳島臨床細胞学会学術集会(Web開催), 2022年3月. 松本穣, 松本満, 尾矢剛志 :
胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性,
第41回日本胸腺研究会, 2022年2月. 堀太貴, Shingen Nakamura, Akihiro Tani, Minae Hosoki, Saya Yasui, Hiroki Yamagami, Ken-ichi Aihara, Yuko Miyagami, Takeshi Oya and 滝下誠 :
T1,
第125回日本内科学会四国地方会, Dec. 2021. 柿本拓海, 清水真祐子, 小川博久, 松本穣, 尾矢剛志, 常山幸一 :
⾮アルコール性脂肪性肝炎の診断におけるα -synuclein 免疫組織化学染⾊の有⽤性,
The 67th Autumn Annual Meeting of Japanese Society of Pathology, 2021年11月. 宮上侑子, 松本穣, 工藤英治, 佐竹宣法, 常山幸一, 尾矢剛志 :
膵神経内分泌腫瘍の一剖検例,
第67回日本病理学会秋期特別総会, 2021年11月. 西條康代, 坂東良美, 尾矢剛志, 松本穣, 上原久典 :
S2838 頭蓋内腫瘍,
日本病理学会中国四国支部学術集会第136回スライドカンファレンス, 2021年10月. 山尾雅美, 山口夏美, 松本麻依, 平田有紀奈, 西尾進, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 奥村和正, 鳥羽博明, 尾矢剛志, 坂東良美, 佐田政隆, 丹黒章 :
硬化性腺症を背景に発生した悪性葉状腫瘍の1例,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 宮崎克己, 山田眞一郎, 森根裕二, 居村暁, 池本哲也, 齋藤裕, 山下祥子, 尾矢剛志, 常山幸一, 島田光生 :
肝内胆管癌予後規定因子としての腫瘍浸潤リンパ球の意義,
第76回日本消化器外科学会総会, 2021年7月. 廣兼百合, 松本穣, 常山幸一, 尾矢剛志 :
von Hippel-Lindau病に関連したendolymphatic sac tumorの一例,
第110回日本病理学会総会, 2021年4月. 山下理子, 常山幸一, 尾矢剛志 :
骨髄膠様変性時の造血微小環境について,
日本病理学会会誌, Vol.110, No.1, 355, 2021年4月. 檜本朱成, 松本穣, 工藤英治, 常山幸一, 尾矢剛志 :
NF1患者に発症した多発性消化管間質腫瘍の1例,
第110回日本病理学会総会, 2021年4月. 住田智志, 清水真祐子, 西條康代, 松本穣, 小川博久, 尾矢剛志, 坂東良美, 上原久典, 常山幸一 :
膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討,
第110回日本病理学会総会, 2021年4月. 松本穣, 尾矢剛志, 松本満 :
Aireレポーターマウスを用いた胸腺内Aire発現樹状細胞の解析,
第40回日本胸腺研究会, 2021年2月. 木内華由, 松本穣, 常山幸一, 尾矢剛志 :
胃腫瘍,
日本病理学会中国四国支部学術集会第133回スライドカンファレンス(Web開催), 2020年11月. 宮崎克己, 森根裕二, 居村暁, 池本哲也, 齋藤裕, 山田眞一郎, 徳田和憲, 沖川昌平, 山下祥子, 尾矢剛志, 常山幸一, 島田光生 :
肝内胆管癌予後規定因子としてのリンパ球CRP比の意義と腫瘍浸潤リンパ球との関係,
第31回日本消化器癌発生学会総会, 2020年11月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 南城和正, 庄野隆志, 牧秀則, 山本清成, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
分類不能型縦隔高悪性度腫瘍の手術例の経験,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 大浦雅博, 中村信元, 堀太貴, 曽我部公子, 原田武志, 藤井志朗, 三木浩和, 賀川久美子, 小林智子, 尾矢剛志, 安倍正博 :
結節性紅斑と悪性腫瘍関連血球貪食症候群を惹起した骨髄異形成症候群の1例,
臨床血液, Vol.61, No.10, 1542, 2020年10月.

(キーワード): *骨髄異形成症候群(合併症) *紅斑-結節性(病因) *血球貪食性リンパ組織球症(病因) ヒト中年(45~64) 男

溝渕海, 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 鷲田武晃, 大野将樹, 尾矢剛志, 常山幸一, 獅々堀正幹 :
深層学習を用いた尿細胞診断の自動化手法,
第19回情報科学技術フォーラム講演論文集(FIT2020)第2分冊, 273-274, 2020年9月. 清水真祐子, 平修, 松本穣, 尾矢剛志, 小川博久, 常山幸一 :
イメージング質量分析によるNASH線維化肝で増加する脂質の同定,
第109回日本病理学会総会, 2020年7月. 廣兼百合, 尾矢剛志, 松本穣, 常山幸一 :
側頭骨腫瘍,
日本病理学会中国四国支部学術集会第132回スライドカンファレンス, 2020年6月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 鈴木恵美, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第39回日本胸腺研究会, 2020年2月. 清水真祐子, 平修, 松本穣, 尾矢剛志, 小川博久, 常山幸一 :
NASH線維化肝におけるpathogen lipidsの同定,
第260回徳島医学会学術集会, 2020年2月. 常山幸一, 清水真祐子, 尾矢剛志, 松本穣, 小川博久 :
自然発症メタボリックシンドローム-NASH-HCCモデルマウスにおけるプレバイオティクスによる腸内細菌叢への介入効果の検討,
第30回日本消化器癌発生学会総会, 2019年11月. 尾矢剛志, 松本穣, 香川典子, 山下理子, 小川博久, 常山幸一 :
小腸腫瘍の1例,
日本病理学会中国四国支部学術集会第130回スライドカンファレンス, 2019年10月. 清水真祐子, 尾矢剛志, 小川博久, 大曲勝久, 常山幸一 :
非アルコール性脂肪肝炎モデルマウスにおける肝線維化発症とコレステロール貪食マクロファージの関連,
第108回日本病理学会総会, 2019年5月.

(キーワード): 肝線維化 / マクロファージ (macrophage) / コレステロール (cholesterol) / 非アルコール性脂肪肝炎

久保美和, 渡邉俊介, 山下理子, 尾矢剛志, 常山幸一 :
子宮頸部病変,
日本病理学会中国四国支部学術集会第128回スライドカンファレンス, 2019年2月. 尾矢剛志, 松本穣, 小川博久, 常山幸一 :
胃病変,
日本病理学会中国四国支部学術集会第128回スライドカンファレンス, 2019年2月. 坂東弘基, 近藤真代, 宮城亮, 荻野広和, 飛梅亮, 尾矢剛志, 小川博久, 河野弘, 豊田優子, 軒原浩, 吾妻雅彦, 後東久嗣, 西良浩一, 西岡安彦 :
エイの刺創後に発症した皮膚Mycobacterium massiliense症の一例,
第69回日本結核病学会中国四国支部会, 2018年12月. 常山幸一, 清水真祐子, 尾矢剛志, 松本穣, 小川博久 :
異なる系統で作成したストレプトゾトシン誘導肝細胞癌モデルマウスの病態比較,
第29回日本消化器癌発生学会総会, 2018年11月. 森本友樹, 小川博久, 尾矢剛志, 常山幸一 :
液状化検体細胞診における迅速質量分析の有用性,
日本臨床細胞学会雑誌, Vol.57, No.Suppl.2, 585, 2018年10月. 林真也, 池田友美, 橋詰香織, 八木美菜, 上原桂月, 尾矢剛志, 酒井剛, 岩渕三哉 :
当院における甲状腺穿刺吸引細胞診判定の適正化,
日本臨床細胞学会雑誌, Vol.56, No.Suppl.1, 230, 2017年4月. 松原崇史, 日野祐資, 荒川文敬, 尾矢剛志, 前田宜延 :
耳下腺腺房細胞癌の1例,
Japanese Journal of Radiology, Vol.35, No.Suppl., 24, 2017年2月. 角谷嘉亮, 日野祐資, 荒川文敬, 尾矢剛志, 前田宜延 :
喉頭に生じたadenoid cystic carcinomaの1例,
Japanese Journal of Radiology, Vol.35, No.Suppl., 33, 2017年2月. 芝原一繁, 辻敏克, 岩城吉孝, 松永正, 棚田安子, 竹原朗, 野崎善成, 佐々木正寿, 前田宣延, 尾矢剛志 :
腹腔鏡下胃部分切除術を施行したBrunner腺腫の1例,
日本臨床外科学会雑誌, Vol.76, 845, 2015年10月. 岩佐桂一, 田森俊一, 川原順子, 望月果奈子, 宮津克幸, 小林孝一郎, 前田宜延, 尾矢剛志, 笠原寿郎 :
PS3の未治療切除不能ALK遺伝子転座陽性肺癌に対してcrizotinibが奏効した1例,
肺癌, Vol.55, No.4, 302, 2015年8月. 上嶋克, 小川加奈子, 植田亮, 品川和子, 圓谷朗雄, 尾矢剛志, 前田宜延 :
0-IIa+IIc様形態を呈した胃NETの1例,
ENDOSCOPIC FORUM for digestive disease, Vol.31, No.1, 102, 2015年5月. 田森俊一, 岩佐桂一, 小林孝一郎, 宮津克幸, 前田宜延, 尾矢剛志, 笠原寿郎 :
RS3PE症候群様症状で発見された肺腺癌の1例,
肺癌, Vol.54, No.6, 877-878, 2014年10月. 林真也, 池田友美, 八木美菜, 上原桂月, 建部勝彦, 尾矢剛志, 酒井剛, 関谷政雄 :
当院における甲状腺穿刺吸引細胞診鑑別困難例の検討,
日本臨床細胞学会雑誌, Vol.53, No.Suppl.2, 624, 2014年10月. 桃井明仁, 永井孝一, 飯酒盃訓充, 本間美帆, 尾矢剛志, 酒井剛, 関谷政雄 :
胸腺原発marginal zone lymphomaの2症例,
日本リンパ網内系学会会誌, Vol.54, 102, 2014年6月. 繁野美紀, 尾矢剛志, 上原桂月, 建部勝彦, 北澤綾, 関谷政雄 :
HHV-8陰性primary effusion lymphoma(PEL)-様リンパ腫の一例,
日本臨床細胞学会雑誌, Vol.52, No.Suppl.2, 698, 2013年10月. 尾矢剛志, 田村哲郎, 関谷政雄 :
小児脳腫瘍の一例,
第77回日本病理学会東北支部学術集会, 2013年7月. 北澤綾, 上原桂月, 尾矢剛志, 酒井剛, 関谷政雄, 大野正文, 西尾美沙樹, 内山三枝子 :
当院で経験したendometrial intraepithelial carcimomaの細胞像と組織像,
日本臨床細胞学会雑誌, Vol.51, No.Suppl.2, 678, 2012年9月. 桃井明仁, 河本啓介, 飯酒盃訓充, 永井孝一, 酒井剛, 尾矢剛志, 関谷政雄 :
濾胞性リンパ腫と古典的ホジキンリンパ腫を合併した2例,
日本リンパ網内系学会会誌, Vol.52, 130, 2012年5月. 北原哲彦, 青木正, 矢澤正知, 尾矢剛志 :
BAC部分切除後の切除断端近傍に発生した第二癌の1切除例,
肺癌, Vol.52, No.2, 255, 2012年4月. 田村哲郎, 富川勝, 高尾哲郎, 斎藤祥二, 尾矢剛志 :
7 トルコ鞍周辺部肥厚性硬膜炎に伴った下垂体炎の2例(I.一般演題,第93回新潟内分泌代謝同好会),
新潟医学会雑誌, Vol.126, No.1, 59-60, 2012年1月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564289196905472

(CiNii: 1050564289196905472) 内山昌則, 村田大樹, 大野正文, 尾矢剛志 :
PD2-24 腹痛・発熱で発症した卵巣粘液性嚢胞腺腫の1手術例(ポスター展示2),
日本小児外科学会雑誌, Vol.48, No.3, 636, 2012年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11164/jjsps.48.3_636_2
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204833129344; ● Search Scopus @ Elsevier (DOI): 10.11164/jjsps.48.3_636_2

(DOI: 10.11164/jjsps.48.3_636_2, CiNii: 1390001204833129344) 内山昌則, 村田大樹, 酒井剛, 尾矢剛志 :
乳幼児脂肪芽腫2例と幼児線維性過誤腫1例の検討,
小児がん, Vol.48, 332, 2011年11月. 北原哲彦, 青木正, 白戸亨, 矢澤正知, 尾矢剛志 :
血痰を契機に発見された肺原発淡明細胞腺癌の1切除例,
肺癌, Vol.51, No.4, 279, 2011年8月. 尾矢剛志, 酒井剛, 関谷政雄, 川口誠 :
左足皮下腫瘍の一例,
第73回日本病理学会東北支部学術集会, 2011年7月. 永井孝一, 桃井明仁, 飯酒盃訓充, 尾矢剛志, 酒井剛, 関谷政雄 :
全身性エリテマトーデス，慢性関節リウマチに合併した悪性リンパ腫,
日本リンパ網内系学会会誌, Vol.51, 95, 2011年6月. 小倉良介, 近貴志, 田村哲郎, 尾矢剛志 :
9 剖検例からみた中枢神経系原発悪性リンパ腫の進展についての考察(一般演題,第36回上信越神経病理懇談会),
新潟医学会雑誌, Vol.125, No.4, 241, 2011年4月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564289195782528

(CiNii: 1050564289195782528) 中島典子, 佐藤由子, 片野晴隆, 長谷川秀樹, 熊坂利夫, 羽田悟, 田中伸哉, 笠井孝彦, 鄭子文, 飯塚利彦, 仲里巌, 樋野陽子, 濱松晶彦, 堀尚, 田中智之, 長谷川章雄, 尾矢剛志, 佐多徹太郎 :
2009H1N1パンデミックインフルエンザウイルス感染症20剖検例の臨床病理学的解析,
日本病理学会会誌, Vol.100, No.1, 373, 2011年3月. 尾矢剛志, 武田幸彦, 酒井剛, 関谷政雄, 山崎学 :
下顎骨腫瘍の一例,
第72回日本病理学会東北支部学術集会, 2011年2月. 関庄二, 妻木範行, 松井好人, 川口善治, 阿部由美子, 鈴木賀代, 岩井昭子, 佐野明美, 尾矢剛志, 池川志郎, 木村友厚 :
CILP(cartilage intermediate layer protein)トランスジェニックマウスの椎間板変性促進効果,
日本整形外科學會雜誌, Vol.84, No.8, S1247, 2010年8月. 中川泰三, 石井陽子, 石澤伸, 濱島丈, 笹原正清, 尾矢剛志 :
腎切除後の糸球体リモデリングに対する血小板由来増殖因子(PDGF)β受容体抑制の影響,
日本病理学会会誌, Vol.99, No.1, 192, 2010年3月. 尾矢剛志, 濱島丈, 笹原正清 :
Valsalva洞動脈瘤破裂による心タンポナーデの1剖検例,
日本病理学会会誌, Vol.99, No.1, 267, 2010年3月. 尾矢剛志, 酒井剛, 関谷政雄 :
大腿軟部腫瘍の一例,
第70回日本病理学会東北支部学術集会, 2010年2月. 田邊繁世, 津畑豊, 安城淳哉, 秋山史大, 尾矢剛志, 今井直史, 西慎一, 成田一衛 :
高度腎機能障害で発見され，ステロイド治療が著効したIgG4関連間質性腎炎の一例,
日本腎臓学会誌, Vol.51, No.6, 671, 2009年8月. 末山博男, 福田貴徳, 関谷政雄, 酒井剛, 尾矢剛志 :
4 化学放射線療法時代の食道癌の剖検所見(I.一般演題,第10回新潟食道・胃癌研究会),
新潟医学会雑誌, Vol.123, No.5, 262, 2009年5月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282814217955200

(CiNii: 1050282814217955200) 山崎隆志, 石井陽子, 濱島丈, 石澤伸, 尾矢剛志, Hemragul Sabit, 徐桂華, 松島貴子, 笹原正清 :
末梢神経の再生におけるPDGF受容体および細胞シグナル活性化の解析,
日本病理学会会誌, Vol.98, No.1, 212, 2009年3月. 中川泰三, 尾矢剛志, 石井陽子, 石澤伸, 濱島丈, 倉茂洋一, 泉野潔, 笹原正清 :
条件的KOマウスを用いた成体期腎糸球体における血小板由来増殖因子(PDGF)beta受容体の役割,
日本病理学会会誌, Vol.98, No.1, 235, 2009年3月. 尾矢剛志, 酒井剛, 関谷政雄 :
Capnocytophaga canimorsusによる敗血症の1剖検例,
日本病理学会会誌, Vol.98, No.1, 343, 2009年3月. 加藤一郎, 鈴木ひかり, 尾矢剛志, 川口博, 高沢伸, 岡本宏, 戸邊一之, 笹原正清, 平賀紘一 :
変異型CaM Kinase2(T286D)遺伝子導入マウスにおける重症糖尿病とその発症機序の解析,
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 3T21-5, 2008年11月. 徳永綾乃, 尾矢剛志, 元村拓, 中村千恵子, 石井陽子, 石澤伸, 金森昌彦, 木村友厚, 笹原正清 :
血小板由来増殖因子β受容体は間葉系間質細胞機能を強く制御する,
日本整形外科學會雜誌, Vol.82, No.8, S1222, 2008年8月. 濱島丈, 尾矢剛志, 石井陽子, 石澤伸, 笹原正清 :
肘部軟部腫瘍の一例,
第 61 回日本病理学会中部支部交見会, 2008年7月. 永井正一, 尾矢剛志, 濱田秀雄, 野本一博, 栗本昌紀, 遠藤俊郎 :
脳室発生の高悪性度紡錘形細胞腫瘍の一例,
Brain Tumor Pathology, Vol.25, No.Suppl., 131, 2008年5月. 谷奈津美, 林龍二, 松島千紘, 山田徹, 河岸由紀男, 三輪敏郎, 松井祥子, 丸山宗治, 戸邉一之, 尾矢剛志, 菓子井達彦 :
7.大腿骨遠位部転移を来し,単関節炎症状を生じた肺腺癌の1剖検例(第57回日本肺癌学会北陸支部会,北陸支部,支部活動),
肺癌, Vol.48, No.2, 142, 2008年4月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854177281199872

(CiNii: 1570854177281199872) 鈴木ひかり, 薄井勲, 尾矢剛志, 加藤一郎, 山崎夕, 藤坂志帆, 仙田聡子, Agussalim Bukhari, 浅水幸恵, 金谷由紀子, 石木学, 浦風雅春, 高沢伸, 岡本宏, 笹原正清, 小林正, 戸邉一之 :
インスリン分泌低下型糖尿病モデルマウスにおける糖尿病性腎症とPDGF経路についての検討,
糖尿病, Vol.51, No.Suppl.1, S-296, 2008年4月. 藤坂志帆, 薄井勲, 尾矢剛志, 金谷由紀子, 山崎夕, Agussalim Bukhari, 鈴木ひかり, 仙田聡子, 高崎一朗, 常山幸一, 浦風雅春, 小林正, 戸辺一之 :
テルミサルタンは脂肪組織のM1マクロファージを選択的に減少させることでインスリン抵抗性を改善する,
糖尿病, Vol.51, No.Suppl.1, S-348, 2008年4月. 中川泰三, 泉野潔, 徳永綾乃, 尾矢剛志, 石井陽子, 供田文宏, 井上博, 笹原正清 :
Cre-lox P系を用いた制限的ノックアウト(KO)による成体期の糸球体におけるPDGFR-βの機能解析,
日本腎臓学会誌, Vol.50, No.3, 292, 2008年4月. 徳永綾乃, 尾矢剛志, 石井陽子, 石澤伸, 濱島丈, 藤森俊彦, 鍋島陽一, 梅澤明弘, 笹原正清 :
間葉系間質細胞の機能制御因子としてのPDGF受容体βの可能性,
日本病理学会会誌, Vol.97, No.1, 310, 2008年3月. 鄭蓮順, 石井陽子, 尾矢剛志, 徳永綾乃, 濱島丈, 松島貴子, 倉茂洋一, 申杰, 石澤伸, 近藤隆, 笹原正清 :
PDGF-Bは，細胞内カルシウムイオン濃度上昇の抑制を介して，酸化ストレス性細胞死から神経細胞を保護する,
日本病理学会会誌, Vol.97, No.1, 380, 2008年3月. 田中淳, 堀場千尋, 尾矢剛志, 野本一博, 福岡順也, 徳永綾乃, 濱島丈, 石井陽子, 石澤伸, 笹原正清 :
診断困難な脳室発生の高悪性度紡錘形細胞腫瘍の一例,
日本病理学会会誌, Vol.97, No.1, 389, 2008年3月. 鈴木ひかり, 薄井勲, 尾矢剛志, 加藤一郎, 山崎夕, 藤坂志帆, Agussalim Bukhari, 浅水幸恵, 金谷由紀子, 石木学, 浦風雅春, 高沢伸, 岡本宏, 笹原正清, 小林正, 戸邉一之 :
変異型CaM Kinase 2トランスジェニックマウスはインスリン依存型糖尿病・糖尿病性腎症を呈し，腎でのPDGF-B発現が増強する,
日本内分泌学会雑誌, Vol.83, No.4, 940, 2008年3月. 嶋田孝紀, 前田宜延, 尾矢剛志, 福岡順也 :
119 Mixed squamous cell and glandular papillomaの1例(呼吸器1(5),一般演題,第46回日本臨床細胞学会秋期大会),
日本臨床細胞学会雑誌, Vol.46, No.2, 471, 2007年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854177278178176

(CiNii: 1570854177278178176) 鈴木ひかり, 薄井勲, 尾矢剛志, 加藤一郎, 山崎夕, 藤坂志帆, Agussalim Bukhari, 浅水幸恵, 金谷由紀子, 石木学, 浦風雅春, 高沢伸, 岡本宏, 笹原正清, 戸邉一之, 小林正 :
腎症変異型CaM Kinase2トランスジェニックマウス(インスリン分泌低下型糖尿病モデルマウス)における腎糸球体病変とPDGFシグナルについての検討,
糖尿病合併症, Vol.21, No.Suppl.1, 109, 2007年9月. 森田誠市, 尾矢剛志, 石井陽子, アムラサビット, 徳永綾乃, 石澤伸, 松島貴子, 倉茂洋一, 笹原正清 :
マウス肝星細胞活性化における血小板由来増殖因子β受容体の役割,
日本病理学会会誌, Vol.96, No.1, 172, 2007年2月. 鄭蓮順, 石井陽子, 尾矢剛志, アムラサビット, 石澤伸, 松島貴子, 倉茂洋一, 笹原正清 :
PDGF-Bは酸化ストレス誘導性細胞死から神経細胞を保護し，その作用はPI3K/AKT経路を介する,
日本病理学会会誌, Vol.96, No.1, 175, 2007年2月. 徳永綾乃, 尾矢剛志, 石井陽子, アムラサビット, 松島貴子, 倉茂洋一, 石澤伸, 金森昌彦, 笹原正清 :
皮膚培養線維芽細胞の遊走におけるPDGFβ受容体の機能解析,
日本病理学会会誌, Vol.96, No.1, 320, 2007年2月. 堯天孝之, 笹原正清, 尾矢剛志, 石井陽子, 石澤伸 :
乳幼児突然死症候群と診断された症例の死因の検討，特に，肺胞出血と微小脳石灰化について,
日本病理学会会誌 (0300-9181)96巻1号 Page356(2007.02), Vol.96, No.1, 356, 2007年2月. Muhammad Andi Ichsan, 加藤一郎, 尾矢剛志, 笹原正清, 高澤伸, 岡本宏, 早坂征次, 高澤久美, 平賀紘一 :
糖尿病網膜症類似病変を発症する常時活性化型CaMキナーゼ2遺伝子導入マウスの解析(その2),
眼科臨床医報, Vol.101, No.1, 95, 2007年1月. 藤井拓人, 渡辺智子, 尾矢剛志, 堀川直樹, 田渕圭章, 竹口紀晃, 塚田一博, 酒井秀紀 :
ヒト胃癌におけるaquaporin-5の機能,
日本生理学会大会発表要旨集, Vol.2007, No.0, 77, 2007年.

(要約): Aquaporins (AQPs) are water channel proteins expressed in various organs and tissues. So far abnormal expression of AQPs has been reported in several cancer tissues, but the function of AQP in human cancer has been little known. Here, we compared the protein expression levels of AQP3, 4 and 5 between human gastric cancer tissue and its accompanying normal mucosa in the upper or middle part of the stomach. It was found that AQP5 was significantly upregulated in the intestinal type of gastric adenocarcinomas but not in diffuse type of adenocarcinomas. AQP5 was localized in the apical membrane of the cancer cells. Expression of AQP4 was down-regulated both in intestinal and diffuse types of adenocarcinomas. No significant expression of AQP3 was observed in the cancer and normal tissues. To clarify the function of AQP5 in gastric adenocarcinomas, we transiently expressed AQP5 in a poorly differentiated human gastric adenocarcinoma cell line (MKN45). Interestingly, AQP5-expressing cell increased the number of differentiated cells. The AQP5 expression increased an activity of alkaline phosphatase, a marker for the intestinal epithelial cell type of cancer cells and expression level of laminin, an epithelial cell marker. Upregulation of AQP5 may be involved in the tumor differentiation of human stomach. <b>[J Physiol Sci. 2007;57 Suppl:S77]</b>
(出版サイトへのリンク): ● Publication site (DOI): 10.14849/psjproc.2007.0_077_3
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282680705874304; ● Search Scopus @ Elsevier (DOI): 10.14849/psjproc.2007.0_077_3

(DOI: 10.14849/psjproc.2007.0_077_3, CiNii: 1390282680705874304) 嶋田孝紀, 前田宜延, 尾矢剛志 :
P-39 肺原発性滑膜肉腫の1例(呼吸器1-(4),一般演題・示説,第45回日本臨床細胞学会秋期大会),
日本臨床細胞学会雑誌, Vol.45, No.2, 432, 2006年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854177256340224

(CiNii: 1570854177256340224) M. Andi Ichsan, 加藤一郎, 尾矢剛志, 登美斉俊, 立川正憲, 細谷健一, 笹原正清, 高沢伸, 岡本宏, 早坂征次, 平賀紘一 :
1型糖尿病モデルマウスにおける糖尿病性網膜病変の解析,
生化学, Vol.78, No.8, 793, 2006年8月. Muhammad Andi Ichsan, 加藤一郎, 尾矢剛志, 笹原正清, 高澤伸, 岡本宏, 早坂征次, 高澤久美, 平賀紘一 :
糖尿病網膜症類似病変を発症する常時活性化型CaMキナーゼ2遺伝子導入マウスの解析,
眼科臨床医報, Vol.100, No.6, 459, 2006年6月. 梅村公子, 加藤一郎, 平島豊, 石井陽子, 尾矢剛志, 林央周, 平賀紘一, 遠藤俊郎 :
一過性局所脳虚血におけるPAF-AHr神経保護作用についてトランスジェニックマウスを用いての検討,
神経組織の成長・再生・移植研究会学術集会プログラム, 2006年5月. 山崎隆志, 尾矢剛志, Sabit Hemragul, 石井陽子, 石澤伸, 古田勲, 笹原正清 :
末梢神経再生におけるPDGF受容体およびシグナル伝達に関する検討,
日本病理学会会誌, Vol.95, No.1, 230, 2006年4月. 加藤一郎, 平賀紘一, 尾矢剛志, 細谷健一, 高沢伸, 岡本宏 :
変異型CaM Kinase2トランスジェニック糖尿病モデルマウスにおける網膜病変の発症とその集学的解析,
糖尿病, Vol.49, No.Suppl.1, S164, 2006年4月. 香川正太, 石原元, 添田義行, 恒枝宏史, 和田努, 尾矢剛志, 小林正, 笹岡利安 :
SH2 Containing 5'-Inositol Phosphatase 2(SHIP2)全身過剰発現が個体でのインスリン作用に与える影響の検討,
糖尿病, Vol.49, No.Suppl.1, 268, 2006年4月. 川村しのぶ, 木屋千恵子, 尾矢剛志, 坂井祐太, 中川加奈子, 江尻哲, 福岡順也 :
骨盤腔中の悪性孤発性線維性腫瘍 1症例報告,
日本病理学会会誌, Vol.95, No.1, 385, 2006年4月. 関庄二, 川口善治, 千葉一裕, 三上靖夫, 尾矢剛志, 三尾太, 森正樹, 益田郁子, 鎌田修博, 久保俊一, 戸山芳昭, 木村友厚, 池川志郎 :
腰椎椎間板ヘルニアの遺伝子解析,
日本整形外科學會雜誌, Vol.80, No.4, S390, 2006年4月. 中川加奈子, 木屋千恵子, 森谷鈴子, 室坂千鶴子, 中村隆文, 坂井祐太, 田中伴典, 江尻哲, 尾矢剛志, 福岡順也 :
P-145 Giant Sertoli-stromal Cell Tumor with Rhabdomyoblastic Element of the Ovary,
日本臨床細胞学会雑誌, Vol.45, No.1, 283, 2006年3月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572543026698551424

(CiNii: 1572543026698551424) Muhammad Andi Ichsan, 加藤一郎, 尾矢剛志, 笹原正清, 高澤伸, 岡本宏, 早坂征次, 高澤久美, 平賀紘一 :
糖尿病網膜症類似病変を発症する常時活性化型CaMキナーゼ2遺伝子導入マウスの解析,
日本眼科学会雑誌, Vol.110, 197, 2006年3月. 前田美代子, 和田重人, 山田なつめ, 尾矢剛志, 古田勲 :
上顎に転移した肝癌の1例,
日本口腔外科学会雑誌, Vol.51, No.12, 640-641, 2005年12月. 嶋田孝紀, 宮ヶ丁芙実, 新出友美, 前田宜延, 尾矢剛志 :
胞巣型横紋筋肉腫の1例(脳・頭頸部-(1), 第44回日本臨床細胞学会秋期大会),
日本臨床細胞学会雑誌, Vol.44, No.2, 349, 2005年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571417126969856640

(CiNii: 1571417126969856640) 浦風雅春, 柳楽清文, 日高隆雄, 尾矢剛志, 石澤伸, 齋藤滋, 小林正 :
Struma ovarii with papillary carcinomaの一例,
日本内分泌学会雑誌, Vol.81, No.2, 341, 2005年9月. 加藤一郎, 尾矢剛志, 高沢伸, 岡本宏, 笹原正清, 平賀紘一 :
Mutant CaM Kinase2遺伝子導入による1型糖尿病および糖尿病性腎症モデルマウスの新規開発,
糖尿病, Vol.48, No.Suppl.2, S220, 2005年4月. Zhiyang Gao, 笹原正清, 笹岡利安, 尾矢剛志, 石井陽子, Hemragul Sabit, 石澤伸 :
The activation of ERKI/2 and JNK,but not p38,was attenuated after PDGFR-β depletion,
日本病理学会会誌, Vol.94, No.1, 233, 2005年3月. 石澤伸, 高橋博之, 尾矢剛志, 常山幸一 :
Diffuse-type giant cell tumorの1例,
第54回日本病理学会中部支部交見会, 2004年12月. 石井陽子, 野上重治, 川口誠, 尾矢剛志, 笹原正清 :
Expression analysis of ATBF1 and ZFH4,the zinc-finger and homeodomain family proteins,in developing rat brains,
神経化学, Vol.43, No.2-3, 485, 2004年8月. 尾矢剛志, 石澤伸, 石井陽子, 笹原正清 :
乳腺腫瘤の一例,
第53回中部支部交見会, 2004年7月. 石井陽子, 尾矢剛志, 鄭蓮順, 高之揚, 高川清, アムラサビット, 笹原正清 :
マウス脳cyroinjuryにおけるPDGF-β受容体発現の解析,
日本病理学会会誌, Vol.93, No.1, 249, 2004年5月. Zhiyang Gao, 石井陽子, 尾矢剛志, 高川清, 川口誠, 笹岡利安, 内藤麻衣子, 小林正, 笹原正清 :
Akt activation is attenuated after PDGFR-β knockout in fibroblast cells,
日本病理学会会誌, Vol.93, No.1, 252, 2004年5月. 大和太郎, 温井剛史, 菅原浩之, 今井哲也, 藤岡重一, 村田修一, 若狭林一郎, 尾矢剛志 :
胃潰瘍を契機に腸管気腫,門脈内ガス像を呈した1例,
日本腹部救急医学会雑誌, Vol.24, No.2, 543, 2004年2月. 嶋田孝紀, 高田益子, 宮ヶ丁芙実, 前田雅美, 前田宜延, 尾矢剛志, 舘野政也 :
82.乳腺のglycogen-rich clear cell carcinomaの3例(乳腺4)(第42回日本臨床細胞学会秋期大会),
日本臨床細胞学会雑誌, Vol.42, No.2, 382, 2003年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1574231876659643904

(CiNii: 1574231876659643904) 野上重治, 石井陽子, 川口誠, 坂田宣夫, 尾矢剛志, 高川清, 金森昌彦, 木村友厚, 笹原正清 :
発達ラット脳におけるATBF1及びZFH-4転写因子の発現解析,
日本整形外科學會雜誌, Vol.77, No.8, S1173, 2003年8月. 石井陽子, 川口誠, 高川清, 尾矢剛志, 野上重治, Zhi-Yang Gao, 笹原正清 :
ラット発達期脳におけるATBF1の定量的解析と神経分化過程における発現の検討,
日本病理学会会誌, Vol.92, No.1, 263, 2003年4月. 尾矢剛志, 笹原正清, 中川孝子, 横澤隆子 :
糖尿病性腎症に対するcaptopril,aminoguanidine,butylated hydroxytoluenne,桂枝茯苓丸の効果の比較検討,
日本病理学会会誌, Vol.92, No.1, 302, 2003年4月. 宮ヶ丁芙実, 嶋田孝紀, 前田宜延, 舘野政也, 尾矢剛志 :
64 術前細胞診において推定し得たpleomorphic carcinomaの一例(第41回日本臨床細胞学会秋期大会),
日本臨床細胞学会雑誌, Vol.41, No.2, 414, 2002年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698601868146048

(CiNii: 1571698601868146048) 尾矢剛志, 野上重治, 石井陽子, 大森義明, 高川清, 川口誠, 笹原正清 :
骨盤・腹腔内に発生した神経外胚葉への分化と骨形成を伴う小細胞肉腫の一例,
日本病理学会会誌, Vol.91, No.1, 331, 2002年3月. Ying-Luan Zhao, 高川清, 尾矢剛志, 大和田幸嗣, 川口誠, 石井陽子, 古田勲, 笹原正清 :
末梢神経再生過程における活性型Srcの発現とその細胞骨格への移行に関する研究,
日本病理学会会誌, Vol.91, No.1, 180, 2002年3月. 石井陽子, 川口誠, 野上重治, 高川清, 尾矢剛志, 井戸章雄, 三浦裕, 橋本知子[玉置], 坂田宣夫, Ying-luan Zhao, 玉置大器, 笹原正清 :
ATBF1(AT-motif Binding Factor 1)のラット脳における発現解析,
神経化学, Vol.40, No.2-3, 366, 2001年9月. 尾矢剛志, Yingluan Zhao, 笹原正清 :
末梢神経再生におけるPDGF-B発現,
神経化学, Vol.40, No.2-3, 372, 2001年9月. 嶋田孝紀, 前田雅美, 前田宜延, 舘野政也, 尾矢剛志 :
109 顔面に発生した血管肉腫の一例,
日本臨床細胞学会雑誌, Vol.40, No.2, 365, 2001年9月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571698601869174784

(CiNii: 1571698601869174784) 川口誠, 三浦裕, 井戸章雄, 森永伴法, 坂田宣夫, 尾矢剛志, 橋本知子[玉置], 笹原正清, 小泉富美朝, 玉置大器 :
ATBF1(AT-motif binding factor 1)におけるDNA/RNA-dependent ATPase活性の検討,
日本病理学会会誌, Vol.90, No.1, 205, 2001年3月. 尾矢剛志, 趙英れん, 高川清, 石井陽子, 川口誠, 笹原正清 :
末梢神経再生におけるPDGF-Bの発現に関する検討,
日本病理学会会誌, Vol.90, No.1, 154, 2001年3月. 趙英れん, 高川清, 尾矢剛志, 石井陽子, 川口誠, 大和田幸嗣, 古田勲, 笹原正清 :
末梢神経再生過程における活性型srcの発現に関する検討,
日本病理学会会誌, Vol.90, No.1, 163, 2001年3月. 石井陽子, 川口誠, 井戸章雄, 三浦裕, 橋本知子[玉置], 田村周, 高川清, 尾矢剛志, 坂田宣夫, Yingluan Zhao, 笹原正清 :
ラット発達期脳におけるATBF1(AT-motief binding factor 1)発現の解析,
日本病理学会会誌, Vol.90, No.1, 205, 2001年3月. 尾矢剛志, 酒井剛, 若木邦彦, 小泉富美朝 :
脳原発anaplastic large cell lymphomaの一症例,
日本病理学会会誌, Vol.86, No.1, 357, 1997年4月.

研究会・報告書

青山理央, 笹聡一郎, 乾友浩, 青山万理子, 奥村和正, 井上寛章, 鳥羽博明, 後藤正和, 尾矢剛志, 滝沢宏光 :
乳腺腺様嚢胞癌の一例,
第19回日本乳癌学会中国四国地方会, 2022年9月. 秦耕太, 湯浅凌雅, 竹内紗里奈, 山下理子, 尾矢剛志, 常山幸一, 清水真祐子 :
骨髄膠様変性時，臨床検査値と造血幹細胞ニッチはどう変化しているか,
徳島県臨床検査技師会誌, 28, 2021年12月. 竹内紗里奈, 小林由利恵, 山下理子, 尾矢剛志, 常山幸一 :
骨髄膠様変性における造血ニッチ形成細胞についての免疫組織化学的研究,
徳島県臨床検査技師会誌, 18, 2020年12月. 笹原正清, 尾矢剛志 :
2006 年度実施のイタイイタイ病等病理解剖検査報告(症例 1),
平成 18 年度環境省委託業務結果報告書〔イタイイタイ病及び慢性カドミウム中毒等に関する研究(重金属等の健康影響に関する総合研究)〕, 209-213, 2007年. 高川清, 尾矢剛志, 笹原正清 :
イタイイタイ病病理解剖検査成績:症例1 (カドミウムの健康影響に関する研究平成14年度イタイイタイ病及び慢性カドミウム中毒等に関する総合的研究--イタイイタイ病患者等に関する資料の収集・保存等に関する研究班報告) -- (イタイイタイ病患者等の病理解剖記録の収集と保存等に関する研究),
環境保健レポ-ト, No.69, 157-160, 2005年5月.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520291855041043712

(CiNii: 1520291855041043712)

特許: 研究者総覧に該当データはありませんでした。
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補助金・競争的資金: 領域・時期特異的ノックアウトマウスを用いた脳における血小板由来増殖因子の機能解析 (研究課題/領域番号: 18790267 )
神経組織における血小板由来増殖因子機能の解明 (研究課題/領域番号: 16390114 )
末梢神経再生における血小板由来増殖因子B鎖およびβ受容体の機能解明 (研究課題/領域番号: 15790197 )
ノックアウトモデルによる生後脳形成における血小板由来増殖因子の役割の解明 (研究課題/領域番号: 12470053 )
研究者番号（00343179）による検索

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2024年4月25日更新

専門分野・研究分野: 人体病理学 (Pathology)
所属学会・所属協会: 社団法人日本病理学会
社団法人日本臨床細胞学会
United States & Canadian Academy of Pathology
European Society of Pathology
日本癌学会
委員歴・役員歴: 社団法人日本病理学会 (学術評議員 [2004年6月〜2021年3月])
受賞: 2023年8月, 2023年電気学会電子・情報・システム部門大会学生ポスターセッション優秀賞 (電気学会)
活動: 研究者総覧に該当データはありませんでした。

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2024年4月21日更新

2024年4月20日更新

Ｊグローバル

Jグローバル最終確認日: 2024/4/20 01:02
氏名（漢字）: 尾矢剛志
氏名（フリガナ）: オヤタケシ
氏名（英字）: Oya Takeshi
所属機関: 徳島大学大学院医歯薬学研究部准教授

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researchmap最終確認日: 2024/4/21 01:29
氏名（漢字）: 尾矢剛志
氏名（フリガナ）: オヤタケシ
氏名（英字）: Oya Takeshi
プロフィール: リサーチマップAPIで取得できませんでした。
登録日時: 2008/12/24 00:00
更新日時: 2024/2/1 08:44
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所属ID: 0344000000
所属: 徳島大学大学院医歯薬学研究部
部署: 分子病理学分野
職名: 准教授
学位: 医学博士
学位授与機関: *富山医科薬科大学*
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2024年4月20日更新

研究者番号: 00343179

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 准教授

所属（過去の研究課題 情報に基づく）*注記: 2007/4/1 : 富山大学, 大学院・医学薬学研究部, 助教
2006/4/1 : 富山大学, 大学院・医学薬学研究部, 助手
2006/4/1 : 富山大学, 大学院医学薬学研究部, 助手
2005/4/1 : 富山大学, 医学部, 助手
2002/4/1 – 2004/4/1 : 富山医科薬科大学, 医学部, 助手

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 基礎医学 / 実験病理学

研究代表者以外

医学 / 病理 / 実験病理学
生物系 / 医歯薬学 / 基礎医学 / 実験病理学

キーワード

研究代表者

PDGF / 増殖因子 / 神経 / 再生 / Src / シグナル伝達 / Schwann細胞 / 血小板由来増殖因子 / 神経再生 / 末梢神経 / Trapidil / 悩 / 遺伝子組み換え / 脳 / 遺伝子組換え

研究代表者以外

血小板由来増殖因子 / knockout mouse / 神経 / 発達 / FGF / Klotho / 転写因子 / 腎臓 / マウス / apoptosis / 再生 / 受容体 / conditional knockout / 高次脳機能 / 神経伝達 / Conditional knockout / 脳 / ノックアウト / platelet-derived growth factor / brain / development / ZFH transcription factor / kidney / PDGF / Cre lox P / 行動実験 / 神経保護因子 / 神経分化 / Crelox P / knockout / conditional / 線維芽細胞 / Akt / MAP kinase / Cre / loxP / Brain / Behavior analyses / Neurotrophic factor / Receptor / Neuronal differentiation

研究課題研究成果共同研究者

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2019年10月1日

がんの統合的診断・治療を目指した分子から組織のマルチスケール・バイブレーショナル光学顕微鏡の創成（南川丈夫）

南川丈夫古部昭広安井武史松本健志北研二獅々堀正幹南康夫越山顕一朗佐藤克也柳谷伸一郎安倍正博常山幸一冨田江一三木浩和日浅雅博尾矢剛志清水真祐子

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尾矢 剛志

Ｊグローバル

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尾矢剛志