トップ研究者を探す脳動脈瘤と歯周病に関する臨床および基礎的研究

脳動脈瘤と歯周病に関する臨床および基礎的研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K10305
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
脳神経外科学
研究機関 徳島大学
代表研究者 里見 淳一郎
研究分担者 永田 俊彦
研究分担者 多田 恵曜
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2017年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2016年度:2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
2015年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード 脳・神経
くも膜下出血
歯周病
歯周菌
炎症反応
エストロゲン
高塩分摂取
高血圧

研究成果

[学会発表] Treatment strategy and outcom of ruptured vertebral artery dissecting aneurysms

Korai M, Kanematsu Y, Tada Y, Yamaguchi I, Yamamoto N, Yamamoto Y, Satomi J 2017

[学会発表] Pro-inflammatory Response Elicited by Porphyromonas Gingivalis Lipopolysaccharide Exacerbates the Rupture of Experimental Cerebral Aneurysms

Miyamoto T, Kitazato K、Tada Y、Shimada K、Yagi K、 Korai、Maekawa H、Yamaguchi T、 Yoshioka S、 Kinouchi T、 Kanematsu Y、 Satomi J、Nagahiro S 2017

[学会発表] Acute stroke management using image sharing on smart phones and tablet devices

Satomi J, Kanematsu Y, Korai M, Yamamoto Y, Yamamoto N, Mizobuchi Y, Mure H, Tada Y, Nakajima K, Okazaki T, Fujihara T 2017

[学会発表] A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms

J. Satomi, Y. Tada, Y. Kanematsu, K. Kuwayama, K. Yagi, T. Kinouchi, K. Nakajima, N. Matsushita, T. Miyamoto, T. Yamaguchi, M. Korai, H. Mure, K. T. Kitazato, S. Nagahiro 2016

[学会発表] Impact of Periodontal Disease and -Bacteria on Intracranial Aneurysms

S. Yoshioka, Y. Tada, J. Satomi, K. Yagi, K. Naruishi, K. Kuwayama, K. T. Kitazato, T. Miyamoto, Y. Kanematsu, M. Harada, T. Nagata, S. Nagahiro 2016

[学会発表] Early Morphological Changes in Cerebral Arteries of Cerebral Aneurysm Rupture Model Rats

H. Maekawa, T. Miyamoto, K.T. Kitazato, K. Yagi, Y. Tada, K. Shimada, J. Satomi, S. Nagahiro 2016

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

1)Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[雑誌論文] Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan

Tada Y, Yagi K, Uno M, Matsushita N, Kanematsu Y, Kuwayama K, Shimada K, Nishi K, Hirasawa M, Satomi J, Kitazato KT, Kageji T, Matsuura E, Nagahiro S 2015

[雑誌論文] Prevention of Retrograde Blood Flow Into Large or Giant Internal Carotid Artery Aneurysms by Endovascular Coil Embolization with High-Flow Bypass: Surgical Technique and Long-Term Results

Nakajima N, Nagahiro S, Satomi J, Tada Y, Nakajima K, Sogabe S, Hanaoka M, Matsubara S, Uno M, Satoh K 2015

[雑誌論文] Two-layered susceptibility vessel sign on 3-tesla T2*-weighted imaging is a predictive biomarker of stroke subtype

Yamamoto N, Satomi J, Tada Y, Harada M, Izumi Y, Nagahiro S, Kaji R 2015

[雑誌論文] PPARγ-Dependent and -Independent Inhibition of the HMGB1/TLR9 Pathway by Eicosapentaenoic Acid Attenuates Ischemic Brain Damage in Ovariectomized Rats

Sumiyoshi M, Satomi J, Kitazato KT, Yagi K, Shimada K, Kurashiki Y, Korai M, Miyamoto T, Suzue R, Kuwayama K, Nagahiro S 2015

[雑誌論文] The accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats

Sumiyoshi M, Kitazato KT, Yagi K, Miyamoto T, Kurashiki Y, Matsushita N, Kinouchi T, Kuwayama K, Satomi J, Nagahiro S 2015