うつ病患者における幼少期ストレスと白血球5HTT遺伝子発現とDNAメチル化の関連

トップ›研究者を探す›うつ病患者における幼少期ストレスと白血球5HTT遺伝子発現とDNAメチル化の関連

うつ病患者における幼少期ストレスと白血球5HTT遺伝子発現とDNAメチル化の関連

代表研究者	伊賀淳一
研究課題番号	KAKENHI-PROJECT-15K09808
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学精神神経科学
研究機関	愛媛大学
研究期間開始年月日	2015/4/1
研究期間終了年度	2017
研究ステータス	完了 (2017/4/1)
配分額（合計）	4,030,000 (直接経費 :3,100,000、間接経費 :930,000)
配分額（履歴）	2017年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2016年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2015年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード	うつ病アルツハイマー型認知症レビー小体型認知症統合失調症生物学的マーカー血液セロトニントランスポーターバイオマーカー遺伝子発現ＤＮＡメチル化 5HTT TREM2 SNCA DRD2 ABCA7 biomarker depression Alzheimer disease プロモーター遺伝子メチル化遺伝子多型

研究成果

[雑誌論文] Endothelial nitric oxide synthase in rat brain is downregulated by sub-chronic antidepressant treatment

Yoshino Yuta、Ochi Shinichiro、Yamazaki Kiyohiro、Nakata Shunsuke、Iga Jun-ichi、Ueno Shu-ichi 2017

[雑誌論文] Endothelial nitric oxide synthase in rat brain is downregulated by sub-chronic antidepressant treatment.

Yoshino Y, Ochi S, Yamazaki K, Nakata S, Iga JI, Ueno SI 2017

[学会発表] うつ病・双極性障害から認知症移行

伊賀淳一 2017

[雑誌論文] TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

Mise Ayano、Yoshino Yuta、Yamazaki Kiyohiro、Ozaki Yuki、Sao Tomoko、Yoshida Taku、Mori Takaaki、Mori Yoko、Ochi Shinichiro、Iga Jun-ichi、Ueno Shu-ichi 2017

[雑誌論文] MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease

Sao Tomoko、Yoshino Yuta、Yamazaki Kiyohiro、Ozaki Yuki、Mori Yoko、Ochi Shinichiro、Yoshida Taku、Mori Takaaki、Iga Jun-ichi、Ueno Shu-ichi 2017

[雑誌論文] Elevated mRNA expression of CASPR3 in patients with schizophrenia.

Okita M, Yoshino Y, Iga JI, Ueno SI 2017

[雑誌論文] DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.

Funahashi Y, Yoshino Y, Yamazaki K, Mori Y, Mori T, Ozaki Y, Sao T, Ochi S, Iga JI, Ueno SI. 2017

[学会発表] Low methylation rates of SNCA gene intron 1 in dementia with Lewy bodies patients

Jun-ichi Iga, Yuta Yoshino, Yu Funahashi, Kiyohiro Yamazaki, Yoko Mori, Takaaki Mori, Shu-ichi Ueno 2017

[雑誌論文] INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

Yoshino Yuta、Yamazaki Kiyohiro、Ozaki Yuki、Sao Tomoko、Yoshida Taku、Mori Takaaki、Mori Yoko、Ochi Shinichiro、Iga Jun-Ichi、Ueno Shu-Ichi 2017

[雑誌論文] DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.

Ozaki Y, Yoshino Y, Yamazaki K, Sao T, Mori Y, Ochi S, Yoshida T, Mori T, Iga JI, Ueno SI 2017

[学会発表] 老年期うつ病と認知症

伊賀淳一 2017

[雑誌論文] Improvement of Visuo-spatial Function Assessed by Raven's Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment

Yoshino Yuta、Mori Takaaki、Yoshida Taku、Toyota Yasutaka、Shimizu Hideaki、Iga Jun-ichi、Nishitani Shusaku、Ueno Shu-ichi 2017

[雑誌論文] DNA Methylation Changes in Intron 1 of Triggering Receptor Expressed on Myeloid Cell 2 in Japanese Schizophrenia Subjects

Yoshino Yuta、Ozaki Yuki、Yamazaki Kiyohiro、Sao Tomoko、Mori Yoko、Ochi Shinichiro、Iga Jun-ichi、Ueno Shu-ichi 2017

[雑誌論文] Gene Expression and Methylation Analysis of ABCA7 in Patients with Alzheimer's Disease.

Yamazaki K, Yoshino Y, Mori T, Yoshida T, Ozaki Y, Sao T, Mori Y, Ochi S, Iga JI, Ueno SI 2017

[雑誌論文] Neural basis of visual perception and reasoning ability in Alzheimer's disease: correlation between Raven's Colored Progressive Matrices test and <sup>123</sup> I-IMP SPECT imaging results.

Yoshida T, Mori T, Shimizu H, Yoshino Y, Sonobe N, Matsumoto T, Kikuchi K, Miyagawa M, Iga J, Mochizuki T, Ueno SI. 2017

[雑誌論文] Low methylation rates of dopamine receptor D2 gene promoter sites in Japanese schizophrenia subjects.

Yoshino Y, Kawabe K, Mori T, Mori Y, Yamazaki K, Numata S, Nakata S, Yoshida T, Iga J, Ohmori T, Ueno S. 2016

[学会発表] 白血球を用いたTranslational Neuropsychopharmacology

伊賀淳一 2016

[雑誌論文] Elevated TREM2 mRNA expression in leukocytes in schizophrenia but not major depressive disorder.

Yoshino Y, Kawabe K, Yamazaki K, Watanabe S, Numata S, Mori Y, Yoshida T, Iga J, Ohmori T, Ueno S 2016

[雑誌論文] Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects

Yoshino Y, Mori T, Yoshida T, Yamazaki K, Ozaki Y, Sao T, Funahashi Y, Iga JI, Ueno SI. 2016

[学会発表] 統合失調症薬物治療ガイドラインの特徴とアセナピンの位置づけ

伊賀淳一 2016

[雑誌論文] Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease.

Yamazaki K, Yoshino Y, Mori T, Okita M, Yoshida T, Mori Y, Ozaki Y, Sao T, Iga J, Ueno S 2016

[学会発表] Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder

Jun-ichi Iga, Shin-ya Watanabe, Shusuke Numata, Hidehiro Umehara, Akira Nishi, Makoto Kinoshita, Masatoshi Inoshita, Shinji Shimodera, Hirokazu Fujita, and Tetsuro Ohmori 2016

[学会発表] うつ病治療ガイドラインと生物学的マーカー研究

伊賀淳一 2016

[学会発表] 薬物投与計画－薬物相互作用と妊婦、老人における投与計画－

伊賀淳一 2016

[学会発表] 白血球mRNA発現を用いたバイオマーカー

伊賀淳一 2016

[学会発表] うつ病患者における5HTTLPR, DNAメチル化, 遺伝子発現の関連研究

伊賀淳一、渡部真也、沼田周助、梅原英裕、西晃、木下誠、井下真利、下寺信次、藤田博一、大森哲郎 2015

[学会発表] 遺伝子を用いたうつ病診断について

伊賀淳一 2015

[雑誌論文] Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population.

Watanabe SY, Iga J, Numata S, Umehara H, Nishi A, Kinoshita M, Inoshita M, Ohmori T. 2015