トップ研究者を探すてんかんにおける低周波活動の発現機構及び脳内ネットワークの動態解明

てんかんにおける低周波活動の発現機構及び脳内ネットワークの動態解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K09351
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
神経内科学
研究機関 京都大学
代表研究者 井内 盛遠
研究分担者 松本 理器
研究分担者 麻生 俊彦
研究分担者 國枝 武治
研究分担者 池田 昭夫
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2017年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2016年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2015年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード てんかん
低周波活動
脳内ネットワーク
機能的MRI

研究成果

[図書] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy

Matsumoto R, Kunieda T 2018

[学会発表] 難治性部分てんかん患者での発作時高周波律動の時間的周波数変化と臨床相関

藤井大樹, 小林勝哉, 下竹昭寛, 金澤恭子, 菊池隆幸, 吉田和道, 松本理器, 國枝武治, 髙橋良輔 and 池田昭夫 2017

[学会発表] Source localization of seizure focus by wide-band stereoelectroencephalography

Murai T, Matsuhashi M,Hitomi T, Toho M, Kobayashi K, Shimotake A, Inouchi M, Kikuchi K, Yoshida K, Kunieda R, Matsumoto R, Kanda R, Takahashi R, Ikeda A 2017

[学会発表] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A 2017

[学会発表] How do we delineate the source of wide-band EEG data: Epileptic DC shifts and HFO?

Ikeda A, Matsumoto R, Kobayashi K, Kunieda T 2017

[学会発表] Spatio-temporal dynamics of interaction between slow and fast waves in humans during sleep

Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Nakae T, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A 2017

[学会発表] Electric cortical stimulation inhibits interictal epileptiform discharge and related high frequency activity in human epileptic focus.

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A 2017

[学会発表] 質電気刺激による行為関連ネットワークマッピング

下竹昭寛,松本理器,小林勝哉,國枝武治,三國信啓,宮本亨,高橋良輔,池田昭夫 2017

[学会発表] Co-occurrence of slow and high frequency oscillations (HFOs) in invasively recorded, interictal state in epilepsy patients: Is it a 'Red slow'?

Daifu M, Inouchi M, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A 2017

[学会発表] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性:皮質皮質間誘発電位計測時の検討

小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔 and 池田昭夫 2017

[学会発表] Invasive 3D source localization by wide-band electroencephalography findings

Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Ikeda A 2017

[学会発表] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex

Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A 2017

[学会発表] 皮質脳波と高次脳機能ネットワーク

松本理器、下竹昭寛,菊池隆幸,國枝武治、池田昭夫 2017

[学会発表] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment

Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A 2017

[学会発表] Evidence for the engagement of cortico-cortical and cortico-subcortical networks in generation of epileptic spasms: a combined case study using CCEP and EEG-fMRI

Inoue T, Kobayashi K, Matsumoto R, Inouchi M, Togo M, Togawa J, Usami K, Shimotake A, Matsuhashi M, Kikuchi T, Yoshida K, Kawawaki H, Kunieda T, Takahashi R, Ikeda A. 2017

[学会発表] Novel surrogate biomarkers of epileptogenicity using wideband ECoG analyses.

Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Ikeda A 2017

[雑誌論文] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.

Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A 2017

[学会発表] Inhibitory effects of electric cortical stimulation on interictal epileptiform discharges in human epileptic focus.

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N and Ikeda A 2017

[学会発表] Epileptogenicity and related network: Approach from “interventional” clinical neurophysiology. Translatability between basic&clinical studies for the pathophysiology of epilepsy: Approach from Oscillology

Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Ikeda A 2017

[雑誌論文] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms.

Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R. 2017

[学会発表] Invasive 3D source localization by wide-band EEG finding

Murai T, Matsuhashi M, Hitomi T, Kobayashi K, Shimotake A, Inouchi M, Kikuchi T, Yoshida K, Kunieda, T, Matsumoto R, Takahashi R, Ikeda A 2016

[学会発表] CCEPのオフライン解析と解釈(ワークショップ2 CCEPのskills workshop:clinical practice parameter(臨床実践指標)を目指して)

松本理器,小林勝哉,菊池隆幸,國枝武治,池田昭夫 2016

[学会発表] Enhancement of coupling between slow waves and high gamma activities during slow wave sleep in human

Togawa J, Inouchi M, Matsumoto R, Matsuhashi M, Kobayashi K, Usami K, Hitomi T, Kunieda T, Miyamoto S, Takahashi R, Ikeda A 2016

[学会発表] Intracranially recorded ictal DC shifts and HFOs as surrogate markers of epileptogenicity in human focal epilepsy

Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A 2016

[学会発表] Repeated, cortical stimulation can modify the wideband cortical activity correlates of interictal epileptiform discharge

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A 2016

[学会発表] 発作間欠期皮質脳波における徐波と高周波律動の共起:自動検出のための解析方法についての検討

大封昌子,井内盛遠,松橋眞生,金澤恭子,小林勝哉,下竹昭寛,人見健文,菊池隆幸,吉田和道,國枝武治,松本理器,髙橋良輔,池田昭夫 2016

[学会発表] Surrogate marker of intracranially recorded ictal DC shifts and HFOs in human focal epilepsy

Daifu M, Inouchi M, Kanazawa K, Matsuhashi M, Inoue T, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A 2016

[学会発表] Repeated, cortical stimulation inhibits cortical epileptic excitability in human epileptic focus

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Hattori N, Ikeda A 2016

[学会発表] Repeated, cortical stimulation inhibits epileptic excitability in human epileptic focus

Nakatani M, Matsumoto R, Kobayashi K, Hitomi T, Inouchi M, Matsuhashi M, Kinoshita M, Kunieda T, Miyamoto S, Hattori N, Takahashi R, Ikeda A 2016

[学会発表] Co-occurrence of slow shifts and high frequency oscillations(HFOs) in invasively recorded, interictal state: Is it called 'Red slow'?

Daifu M, Inouchi M, Inoue T, Kanazawa K, Matsuhashi M, Kobayashi K, Shimotake A, Hitomi T, Matsumoto R, Kunieda T, Miyamoto S, Takahashi R, Ikeda A 2015

[雑誌論文] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential

Kunieda T, Yamao Y, Kikuchi T, Matsumoto R 2015

[雑誌論文] A possible variant of negative motor seizure arising from the supplementary negative motor area.

Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S 2015

[学会発表] 発作間欠期の徐波と高周波数律動(HFO)の共起:難治部分てんかん患者の皮質脳波の症例検討

井上岳司、井内盛遠、松橋眞生、松本理器、人見健文、大封昌子、小林勝哉、金澤恭子、下竹昭寛、國枝武治、高橋良輔、池田昭夫 2015

[雑誌論文] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation.

Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. 2015