トップ研究者を探すC型肝炎ウイルスによる炎症に起因する肝発癌および癌進展機序とPKRの役割

C型肝炎ウイルスによる炎症に起因する肝発癌および癌進展機序とPKRの役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-15K09006
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 愛媛大学
代表研究者 日浅 陽一
研究期間 開始年月日 2015/4/1
研究期間 終了年度 2017
研究ステータス 完了 (2017/4/1)
配分額(合計) 4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
配分額(履歴) 2017年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2016年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2015年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード Protein kinase R
Hepatocellular carcinoma
C型肝炎ウイルス
eIF2-alpha
PERK
ERストレス
DNMT
MAPK
PKR-like ER kinase
eIF2alpha
AP-1
hepatitis C virus
hepatocellular carcinoma
DNAメチル化
JNK1

研究成果

[図書] 第31回犬山シンポジウム -B型肝炎・C型肝炎・肝癌

渡辺崇夫、徳本良雄、日浅陽一 2018

[雑誌論文] Roles of protein kinase R in cancer: Potential as a therapeutic target.

Watanabe T, Imamura T, Hiasa Y. 2018

[雑誌論文] Cigarette smoking is a risk factor for the onset of fatty liver disease in nondrinkers: A longitudinal cohort study.

Okamoto M, Miyake T, Kitai K, Furukawa S, Yamamoto S, Senba H, Kanzaki S, Deguchi A, Koizumi M, Ishihara T, Miyaoka H, Yoshida O, Hirooka M, Kumagi T, Abe M, Matsuura B, Hiasa Y. 2018

[雑誌論文] Transcatheter Arterial Chemoembolization With or Without Radiofrequency Ablation: Outcomes in Patients With Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma.

Hirooka M, Hiraoka A, Ochi H, Kisaka Y, Joko K, Michitaka K, Hiasa Y. 2018

[図書] 消化器疾患のための栄養療法の手引き

仙波英徳、日浅陽一 2018

[雑誌論文] Nonalcoholic fatty liver with a hepatic arterial buffer response strongly associated with future metabolic disease.

Hirooka M, Koizumi Y, Miyake T, Watanabe T, Yoshida O, Tokumoto Y, Yukimoto A, Nakamura Y, Imai Y, Abe M, Hiasa Y. 2017

[雑誌論文] Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma.

Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T, Hiasa Y. 2017

[学会発表] Patients with HBV and HCV chronic liver disease under surveillance for HCC have a favorable long-term outcome for pancreatic cancer due to early diagnosis and high resection rate.

Kumagi T, Terao T, Hiasa Y, et al. 2017

[図書] 消化器疾患 最新の治療 2017-2018

阿部雅則、日浅陽一 2017

[学会発表] Validation of the GLOBE score and the UK-PBC risk score in Japanese patients.

Yoshida O, Abe M, Hiasa Y, et al. 2017

[学会発表] Increased frequency of myeloid-derived suppressor cells in patients with non-alcoholic fatty liver disease.

Abe M, Nakamura Y, Hiasa Y, et al. 2017

[学会発表] No-touch radio frequency ablation is an ideal method to prevent intrahepatic metastasis of hepatocellular carcinoma.

Hiraoka m, Hiraoka A, Hiasa Y, et al. 2017

[雑誌論文] Predictors of treatment efficacy and ALT non-normalization with sofosbuvir/ribavirin therapy for patients with hepatitis C virus genotype 2.

Watanabe T, Tokumoto Y, Joko K, Michitaka K, Horiike N, Tanaka Y, Tada F, Kisaka Y, Nakanishi S, Nonaka T, Yamauchi K, Hirooka M, Abe M, Hiasa Y. 2017

[雑誌論文] Antiemetic Effectiveness and Cost-Saving of Aprepitant plus Granisetron Is Superior to Palonosetron in Gastrointestinal Cancer Patients Who Received Moderately Emetogenic Chemotherapy.

Toda H, Kawazoe H, Yano A, Yamamoto Y, Watanabe Y, Yamamoto Y, Hiasa Y, Yakushijin Y, Tanaka A, Araki H. 2017

[図書] 肝疾患治療マニュアル

徳本良雄、日浅陽一 2017

[図書] 1336専門家による私の治療 2017-18年度版

徳本良雄、日浅陽一 2017

[図書] 消化器疾患 最新の治療2017-2018

阿部雅則、日浅陽一 2017

[学会発表] Comparison with Child-Pugh, liver damage and newly proposed ALBI-grade for assessment of hepatic function and predicting prognosis of Japanese patients with hepatocellular carcinoma.

Hiraoka A, Kumada T, Hiasa Y, et al. 2017

[雑誌論文] Clinical utility of multipolar ablation with a 3-D simulator system for patients with liver cancer.

Hirooka M, Koizumi Y, Imai Y, Nakamura Y, Yukimoto A, Watanabe T, Yoshida O, Tokumoto Y, Abe M, Hiasa Y. 2017

[図書] 今日の治療指針2017年度版

日浅陽一 2017

[学会発表] Increase of serum chylomicron triglyceride concentration associated with intestinal overproduction of chylomicron triglyceride in nonobese, nondiabetic and normolipidemic NASH patients.

Utsunomiya H, Hanayama M, Hiasa Y, et al. 2017

[雑誌論文] Characterization of Liver Monocytic Myeloid-Derived Suppressor Cells and Their Role in a Murine Model of Non-Alcoholic Fatty Liver Disease

Yao L, Abe M, Kawasaki K, Akbar SM, Matsuura B, Onji M, Hiasa Y. 2016

[雑誌論文] Simeprevir with peginterferon/ribavirin for patients with hepatitis C virus genotype 1: high frequency of viral relapse in elderly patients.

Watanabe T, Joko K, Hiasa Y, et al. 2016

[学会発表] Protein kinase R modulates DNA methylation in hepatocellular carcinoma with HCV infection

Takao Watanabe, Yoshio Tokumoto, Masashi Hirooka, Osamu Yoshida, Yohei Koizumi, Yusuke Imai, Yoshiko Nakamura, Masanori Abe, Yoichi Hiasa 2016

[雑誌論文] Low alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease

Miyake T, Kumagi T, Hirooka M, Furukawa S, Yoshida O, Koizumi M, Yamamoto S, Watanabe T, Yamamoto Y, Tokumoto Y, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y. 2016

[学会発表] Down-regulated acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) has a role in suppression of apoptosis, and is associated with poor prognosis in patients with hepatocellular carcinoma.

Ohio Y, Koizumi M, Hiasa Y, et al. 2016

[図書] 臨牀消化器内科 10月号

徳本良雄、日浅陽一 2016

[雑誌論文] Usefulness of a New Three-Dimensional Simulator System for Radiofrequency Ablation

Hirooka M, Koizumi Y, Imai Y, Miyake T, Watanabe T, Yoshida O, Takeshita E, Tokumoto Y, Abe M, Hiasa Y. 2016

[図書] Modern Physician 11月号

吉田理、三宅映己、日浅陽一 2016

[図書] 肝臓クリニカルアップデート vol. 2

渡辺崇夫、日浅陽一 2016

[雑誌論文] Effects of long-term entecavir treatment on the incidence of hepatocellular carcinoma in chronic hepatitis B patients

Watanabe T, Tokumoto Y, Joko K, Michitaka K, Mashiba T, Hiraoka A, Ochi H, Koizumi Y, Tada F, Hirooka M, Yoshida O, Imai Y, Abe M, Hiasa Y. 2016

[学会発表] Unregulated palmitic acid absorption with altered intestinal transporters in non-alcoholic steatohepatitis (NASH).

Utsunomiya H, Yamamoto Y, Hiasa Y, et al. 2016

[学会発表] The efficacy of radio frequency ablation combined with trans catheter hepatic chemoembolization for patients with BCLC stage B hepatocellular carcinoma.

Hirooka M, Hiraoka A, Hiasa Y, et al. 2016

[学会発表] The roles of protein kinase R and its possibility as a therapeutic target in hepatocellular carcinoma with hepatitis C virus infection.

Watanabe T, Tokumoto Y, Hiasa Y, et al. 2016

[学会発表] Patients with HBV and HCV chronic liver disease under surveillance for HCC are diagnosed with pancreatic cancer at early stages.

Kumagi T, Terao T, Hiasa Y, et al. 2016

[学会発表] HCV関連肝細胞癌におけるProtein kinase Rの役割

渡辺崇夫、日浅陽一 2015

[雑誌論文] Characterization of the biliary tract by virtual ultrasonography constructed by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging

Koizumi Y, Hirooka M, Ochi H, Tokumoto Y, Takechi M, Hiraoka A, Ikeda Y, Kumagi T, Matsuura B, Abe M, Hiasa Y. 2015

[学会発表] C型肝細胞癌におけるProtein kinase Rの役割-c-Fos, c-Jun活性化を介した細胞増殖促進作用

渡辺崇夫、小泉光仁、日浅陽一 2015

B型肝炎ワクチン