脳動脈瘤破裂の病態解析と早期診断・薬物治療へのアプローチ

トップ›研究者を探す›脳動脈瘤破裂の病態解析と早期診断・薬物治療へのアプローチ

代表研究者	永廣信治
研究課題番号	KAKENHI-PROJECT-15H04950
研究種目	基盤研究(B)
研究分野	生物系医歯薬学外科系臨床医学脳神経外科学
研究機関	徳島大学
研究分担者	多田恵曜
研究分担者	兼松康久
研究分担者	桑山一行
研究分担者	八木謙次
研究期間開始年月日	2015/4/1
研究期間終了年度	2017
研究ステータス	完了 (2017/4/1)
配分額（合計）	16,640,000 (直接経費 :12,800,000、間接経費 :3,840,000)
配分額（履歴）	2017年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000) 2016年度：5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000) 2015年度：6,630,000 (直接経費 :5,100,000、間接経費 :1,530,000)
キーワード	脳・神経脳血管病エストロゲン受容体調整薬脳動脈瘤破裂エストロゲン血行動態変化高血圧脳動脈瘤歯周病脳動脈瘤破裂　血行動態変化

研究成果

[雑誌論文] Coloring Technique of Magnetic Resonance Angiography for Superficial Temporal Artery to Middle Cerebral Artery Bypass Surgery

Okazaki Toshiyuki、Irie Shinsuke、Inagaki Toru、Saito Osamu、Yamashina Motoshige、Hayase Hitoshi、Nakagawa Hiroshi、Nagahiro Shinji、Saito Koji 2018

[雑誌論文] Comparison of Clinical Characteristics among Subtypes of Visual Symptoms in Patients with Transient Ischemic Attack: Analysis of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA) Registry

Tanaka Koji、Uehara Toshiyuki、Kimura Kazumi、Okada Yasushi、Hasegawa Yasuhiro、Tanahashi Norio、Suzuki Akifumi、Nakagawara Jyoji、Arii Kazumasa、Nagahiro Shinji、Ogasawara Kuniaki、Uchiyama Shinichiro、Matsumoto Masayasu、Iihara Koji、Toyoda Kazunori、Minematsu Kazuo 2018

[雑誌論文] Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment

Sogabe S, Satomi J, Tada Y, Kanematsu Y, Kuwayama K, Yagi K, Yoshioka S, Mizobuchi Y, Mure H, Yamaguchi I, Abe T, Yamamoto N, Kitazato KT, Kaji R, Harada M, Nagahiro S 2017

[雑誌論文] Treatment Outcome of Carotid Artery Stenting Underwent within 14 Days of Stroke Onset – Consideration of Safety and Efficacy of Urgent Carotid Artery Stenting for Neurologically Progressing Patients

Kanematsu Y, Satomi J, Kuwayama K, Yamaguchi I, Yoshioka S, Kinouchi T, Tada Y, Yamamoto N, Matsubara S, Satoh K, Nagahiro S 2017

[学会発表] Pro-inflammatory Response Elicited by Porphyromonas Gingivalis Lipopolysaccharide Exacerbates the Rupture of Experimental Cerebral Aneurysms

Miyamoto T,Kitazato K、Tada Y、Shimada K、Yagi K、 Korai、Maekawa H、Yamaguchi T、 Yoshioka　S、 Kinouchi T、 Kanematsu Y、 Satomi J、Nagahiro S 2017

[雑誌論文] Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats

Kinouchi Tomoya、Kitazato Keiko T.、Shimada Kenji、Yagi Kenji、Tada Yoshiteru、Matsushita Nobuhisa、Kurashiki Yoshitaka、Satomi Junichiro、Sata Masataka、Nagahiro Shinji 2017

[学会発表] Roles of Neutrophil Extracellular Trap in the Rupture of Intracranial Aneurysm

Korai M, Furukawa H、Kamio Y、Mitsui K、Nagahiro S、Hashimoto T 2017

[雑誌論文] 症例中耳内頚動脈走行異常により拍動性耳鳴を生じた1症例

Kuwayama K, Satomi J, Yamaguchi T, Yamaguchi I, Sogabe S, Yoshioka S, Nagahiro S 2017

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[学会発表] A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms

J. Satomi, Y. Tada, Y. Kanematsu, K. Kuwayama, K. Yagi, T. Kinouchi, K. Nakajima, N. Matsushita, T. Miyamoto, T. Yamaguchi, M. Korai, H. Mure, K. T. Kitazato, S. Nagahiro 2016

[雑誌論文] Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model

Miyamoto T, Kung DK, Kitazato KT, Yagi K, Shimada K, Tada Y, Korai M, Kurashiki Y, Kinouchi T, Kanematsu Y, Satomi J, Hashimoto T, Nagahiro S 2016

[学会発表] Impact of Periodontal Disease and －Bacteria on Intracranial Aneurysms

S. Yoshioka, Y. Tada, J. Satomi, K. Yagi, K. Naruishi, K. Kuwayama, K. T. Kitazato, T. Miyamoto, Y. Kanematsu, M. Harada, T. Nagata, S. Nagahiro 2016

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[学会発表] Early Morphological Changes in Cerebral Arteries of Cerebral Aneurysm Rupture Model Rats

H. Maekawa, T. Miyamoto, K.T. Kitazato, K. Yagi, Y. Tada, K. Shimada, J. Satomi, S. Nagahiro 2016

[学会発表] 3D structure of vasa vasorum in thrombosed rat cerebral aneurysms

H. Maekawa, T. Miyamoto, K.T. Kitazato, S. Nagahiro 2016

[学会発表] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats

T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro 2016

[学会発表] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis

Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro 2016

[雑誌論文] DIAS-J Investigators Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic Stroke

Mori E, Minematsu K, Nakagawara J, Hasegawa Y, Nagahiro S, Okada Y, Truelsen T, Lindsten A, Ogawa A, Yamaguchi T 2015