ベクターコントロールが及ぼす希少野生動物への影響評価と新規感受性評価法の開発

研究課題番号	KAKENHI-PROJECT-15H02825
研究種目	基盤研究(B)
研究分野	総合系環境学環境解析学放射線・化学物質影響科学
研究機関	北海道大学
代表研究者	池中良徳
研究分担者	石塚真由美
研究分担者	水川葉月
研究分担者	中山翔太
研究期間開始年月日	2015/4/1
研究期間終了年度	2017
研究ステータス	完了 (2017/4/1)
配分額（合計）	14,690,000 (直接経費 :11,300,000、間接経費 :3,390,000)
配分額（履歴）	2017年度：3,380,000 (直接経費 :2,600,000、間接経費 :780,000) 2016年度：4,290,000 (直接経費 :3,300,000、間接経費 :990,000) 2015年度：7,020,000 (直接経費 :5,400,000、間接経費 :1,620,000)
キーワード	DDT・IRS ベクターコントロールマラリア誘導性肝臓様細胞 Vector Control DDT 室内限定散布リスク評価ケミカルハザードオミクス ADME 極新鮮肝Bank iHep 野生動物感受性評価化学物質感受性評価希少野生動物異物代謝系極新鮮肝

[学会発表] Novel Mechanism of Rodenticide (warfarin) Resistance of Wild Rats in Tokyo ~ Enhanced Pentose Phosphate Pathway Causes Rapid Metabolism of Warfarin ~

Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2018

[雑誌論文] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species

Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M. 2018

[学会発表] Lead levels in eggs in Kabwe, Zambia: implication of human exposure

Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka 2018

[学会発表] Drug metabolism enzymes in Carnivora species

Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai,　Hazuki Mizukawa, Yoko Mitani, Kei Nomyama, Shinsuke Tanabe and Mayumi Ishizuka 2017

[学会発表] 東京のワルファリン抵抗性ラットの抵抗性獲得機序の解明：ペントースリン酸経路の亢進を通したワルファリン代謝の活性化 Investigation of mechanism of warfarin resistance of wild rats in Tokyo ~ enhanced pentose phosphate pathway causes rapid metabolism of warfarin ~

Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] Indoor exposure for polychlorinated biphenyls (PCBs) in domestic cats ~Pilot study of Mongolian pet cat~

Hazuki Mizukawa, Yoshinori Ikenaka, Tsend-Ayush Sainnoxoi, Kohki Takaguchi, Kei Nomiyama, Shouta M.M. Nakayama, Mayumi Ishizuka 2017

[学会発表] スーパーラットは高NADPH産生能を持つ　～東京の殺鼠剤抵抗性ラットにおける抵抗性獲得機序の解明～

武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美 2017

[学会発表] In situ肝灌流試験によるワルファリン抵抗性クマネズミでのワルファリン代謝能の解明

武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美 2017

[学会発表] 肝灌流試験、in vitro酵素活性試験による東京由来ワルファリン抵抗性クマネズミのワルファリン代謝能の解明

武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美 2017

[雑誌論文] 鳥類で起こっているケミカルハザードとそのメカニズム

中山翔太、水川葉月、池中良徳、石塚真由美 2017

[学会発表] Effects of Organohalogen Compounds on Serum Biochemical Profiles in Cats

Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka 2017

[学会発表] Heavy metal residues in some ready-to-eat meat products marketed in Egypt

Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] Evaluation of utility for stable lead isotope ratios to identify lead sources and verifying biological fractionation of lead isotopes in goats and chickens

Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka 2017

[学会発表] 東京由来殺鼠剤抵抗性ラットを用いた新規抵抗性獲得機序の解明ペントースリン酸経路の亢進による殺鼠剤代謝能の活性化

武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美 2017

[学会発表] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価

野見山桂、西川博之、水川葉月、髙口倖暉、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介 2017

[学会発表] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル（BDE209）は甲状腺機能亢進症を引き起こすのか？

水川葉月、野見山桂、池中良徳、中山翔太、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、笹岡一慶、市居修、Kraisiri Khidkhan、高居名菜、滝口満喜、田辺信介、石塚真由美 2017

[学会発表] Inveatigation of biochemical changes in cat exposed organohalogen compounds

Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka 2017

[学会発表] 鳥類におけるグルクロン酸抱合能の種差の解明と化学物質感受性の推定

新屋惣、池中良徳、中山翔太、水川葉月、伊藤真輝、高江洲昇、齊藤慶輔、渡邊有希子、石塚真由美 2017

[学会発表] Effect of DDTs on gallinacins in the avian immune system

Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia

Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka 2017

[学会発表] ヒト生体試料を用いたネオニコチノイドおよびネオニコチノイド代謝物の分析方法

一瀬貴大，池中良徳，藤岡一俊，平久美子，中山翔太，水川葉月，八木橋美緒，有薗幸司，加藤恵介，高橋圭介，石塚真由美 2017

[雑誌論文] Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea

Chihiro Ishii, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Yutaka Watanuki, Masaaki Fukuwaka, and Mayumi Ishizuka 2017

[学会発表] UDP-glucuronosyltransferase (UGT) among Pinnipedia and other carnivores

Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomiyama, Shinsuke Tanabe, and Mayumi Ishizuka 2017

[学会発表] “First, do no harm” ? balancing the benefits of malaria control against the toxic effects of DDT use

Lesa THOMPSON, Yoshinori IKENAKA, Yared YOHANNES, Atnafu ASSEFA, Johan VAN VUREN, Victor WEPENER, Nico SMIT, Wynand VLOK, Wageh Sobhy DARWISH, Shouta NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA 2017

[学会発表] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats

Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka 2017

[学会発表] 全国規模での鳥類への鉛曝露：曝露指標として骨の利用の可能性

石井千尋，中山翔太，池中良徳，Kataba Andrew，齊藤慶輔，渡辺有希子，槇納好岐，松川岳久，久保田章乃，横山和仁，水川葉月，平田岳史，石塚真由美 2017

[学会発表] ポリ塩化ビフェニル（PCBs）がネコの甲状腺機能に及ぼす影響

水川葉月、高居名菜、野見山桂、高口倖暉、横山望、市居修、滝口満喜、池中良徳、中山翔太、石塚真由美 2017

[学会発表] PCBs曝露がイヌ・ネコの甲状腺ホルモン恒常性へ及ぼす影響

髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、芳之内結加、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介 2017

[学会発表] UDP-glucuronosyltransferase (UGT) 2B genetic feature and activities in Carnivores

Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomyama, Shinsuke Tanabe, and Mayumi Ishizuka, 2017

[学会発表] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia

Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka 2017

[学会発表] Studies on polycyclic aromatic hydrocarbons formation in heat-treated meat

Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[雑誌論文] Concentrations and human health risk assessment of DDT and its metabolites in free-range and commercial chicken products from KwaZulu-Natal, South Africa

Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M. 2017

[学会発表] ザンビア・カブエ鉱床における鉛汚染問題とその解決に向けた取り組み-KAbwe Mine Pollution Amelioration Initiative (KAMPAI Project)-

中山翔太、水川葉月、池中良徳、石塚真由美 2017

[学会発表] 幼児における尿中ネオニコチノイド濃度とその曝露実態の解明

池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、遠山千春、石塚真由美 2017

[学会発表] Discovery of renal biomarkers in birds by transcriptome analysis and glycomics analysis following kidney injury in chicken model

Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] 幼児のネオニコチノイド系農薬の曝露評価に関する研究

池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、平久美子、有薗幸司、高橋圭介、加藤恵介、遠山千春、石塚真由美 2017

[学会発表] Wild rat’s bio-distribution analysis for pesticide DDT from South Africa

Tetsuro Ogawa, Yoshinori Ikenaka, Yared B Yohannes, Lesa Thompson, Johan van Vuren, Victor Wepener, Nico J Smit, Wynand Vlok, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] 代謝酵素の動物種差

石塚真由美、中山翔太、水川葉月、池中良徳 2017

[学会発表] Evaluation of indoor residual spraying DDT for mosquito control: Tissue distribution and gene expression profiling in rat tissues

Emmanuel Temiotan Ogbomida, Alex Ajeh Enuneku, Yoshinori Ikenaka, Yared Beyene Yohannes, Wageh Sobhy Darwish, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] 鳥類医学の発展に向けた新規腎障害マーカーの探索

石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美 2017

[学会発表] Nobel investigation of mechanism of rodenticide resistance ~ enhanced pentose phosphate pathway causes rapid metabolism of warfarin ~

Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] Discovery of renal biomarker in birds by transcriptome analysis of kidney tissues and glycomics analysis of plasma following renal damage in chicken model.

Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2017

[学会発表] エストロジェン類高感度分析法の開発と野生動物におけるスクリーニング

新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、伊藤真輝、高江洲昇、大澤夏生、綿貫豊、石塚真由美 2017

[学会発表] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population

Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka 2017

[学会発表] 幼児および新生児におけるネオニコチノイド系殺虫剤の曝露実態

池中良徳、宮原裕一、一瀬貴大、中山翔太、水川葉月、市川剛、遠山千春、石塚真由美 2017

[学会発表] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル(BDE209)の生体内変化

田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介 2017

[学会発表] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis

Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka 2017

[学会発表] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia

Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka 2017

[学会発表] 高次栄養段階生物への化学物質の感受性の種差

石塚真由美、中山翔太、水川葉月、池中良徳 2017

[学会発表] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価

水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美 2017

[学会発表] UGTの動物種差

石塚真由美、中山翔太、水川葉月、池中良徳 2016

[学会発表] Lead exposure on human samples in African countries and lead pollution in Kabwe, Zambia.

Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka 2016

[学会発表] Cytochrome P450 expression in the rabbit

Walaa Fathy Saad Eldin, Wageh S. Darwish, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka 2016

[学会発表] KAMPAI -Team 2, PAST, PRESENT and FUTURE-

Shouta M.M. Nakayama, John Yabe, Yared Beyene, Haruya Toyomaki, Kaampwe Muzandu, Kennedy Choongo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka. 2016

[学会発表] ネコにおけるポリ塩化ビフェニル（PCBs）の異物代謝機構解明と甲状腺ホルモンへの影響評価

水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美 2016

[学会発表] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価

水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美 2016

[学会発表] 東京由来ワルファリン抵抗性クマネズミクローズドコロニーでのワルファリン体内動態の解明

武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美 2016

[学会発表] N-glycans as potential novel biomarkers for kidney injury in avian species.

Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama,Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka,Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka. 2016

[学会発表] Plasma essential trace element concentrations in dogs with chronic enteropathy.

Nozomu Yokoyama, Hiroshi Ohta, Hazuki Mizukawa, Yumiko Kagawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi. 2016

[学会発表] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis.

Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe. 2016

[学会発表] Investigation of Warfarin Metabolic Ability of Warfarin Resistant Roof Rats by in situ Liver Perfusion.

Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2016

[学会発表] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats.

Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka. 2016

[学会発表] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites.

Nesta Bortey-Sam, Yoshinori Ikenaka, Shouta M.M. Nakayama, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka. 2016

[学会発表] 犬の慢性腸症における血中微量元素プロファイルの解析

横山望, 大田寛, 水川葉月, 賀川由美子, 中山翔太, 佐々木東,森下啓太郎, 中村健介, 池中良徳, 石塚真由美, 滝口満喜 2016

[学会発表] Pb levels and isotope ratio profiles in kidneys of Japanese wild rats

Shouta M.M. Nakayama, Hokuto Nakata, Balazs Oroszlany, Yoshinori Ikenaka, Hazuki Mizukawa, Kazuyuki Tanaka, Tsunehito Harunari, Tsutomu Tanikawa, Yared B. Yohannes, Aksorn Saengtienchai, Mayumi Ishizuka 2016

[学会発表] ヒト尿中のネオニコチノイドおよびその代謝産物の分析法の確立とヒトへの曝露評価

池中良徳、藤岡一俊、平久美子、中山翔太、水川葉月、一瀬貴大、Jemima Tiwaa Marfo、有薗幸司、加藤恵介、石坂真澄、馬場浩司、川上智規、石塚真由美 2016

[学会発表] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs

Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka 2016

[学会発表] 脂肪組織における芳香族炭化水素受容体(AhR)の機能解明

本平航大、池中良徳、ワギダルウィシュ、中山翔太、水川葉月、石塚真由美 2016

[学会発表] Creating a model of renal damage in chicken and glycomic approach to identify novel biomarkers for kidney injury in birds

Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Mayumi Ishizuka 2016

[学会発表] UGT2Bサブファミリーに着目した食肉目におけるグルクロン酸抱合能の動物種差解明

近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美 2016

[学会発表] 家畜・家禽の鉛安定同位体生体内分別の種差および歩哨動物としての有用性評価

栂尾正雄、中山翔太、John Yabe、池中良徳、中田北斗、石井千尋、水川葉月、Yared B. Yohannes、 Aksorn Saengtienchai、石塚真由美 2016

[学会発表] Characteristic for biotransformation of polychrolinated biphenyls in cats.

Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka 2016

[学会発表] メタボローム解析を用いたPCBsによるイエネコの毒性影響評価

西川博之、野見山桂、水川葉月、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介 2016

[学会発表] 化学物質の汚染環境に生きる野生動物の適応戦略

石塚真由美、中山翔太、水川葉月、池中良徳 2016

[学会発表] Is there species difference of biological variation of lead (Pb) isotopic composition between livestock and poultry?

Masao Togao, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yoshinori Ikenaka, Chihiro Ishii, Yared B. Yohannes, Hazuki Mizukawa, Wageh Sobhy Darwish, Aksorn Saengtienchai, Mayumi Ishizuka 2016

[学会発表] Monitoring of blood lead levels (BLLs) in dogs and chickens from lead pollution area, Kabwe, Zambia.

Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka. 2016

[学会発表] In situ肝灌流モデルによる殺鼠剤抵抗性野生クマネズミにおけるワルファリン代謝能の解明

武田一貴、池中良徳、田中和之、中山翔太、谷川力、水川葉月、石塚真由美 2016

[学会発表] 野生げっ歯類の殺鼠剤の抵抗性メカニズムと非対象動物に対する毒性メカニズム

石塚真由美、中山翔太、水川葉月、池中良徳 2016

[学会発表] Pharmacokinetic analysis of warfarin resistant roof rats (Rattus rattus) in Tokyo

Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2016

[学会発表] Lead exposure on human samples in African countries: a mini review

Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka 2016

[学会発表] 野生動物及び実験動物におけるグルクロン酸抱合酵素の動物種差解明

近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美 2016

[学会発表] 鳥類におけるグルクロン酸抱合酵素による薬物代謝

新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、齊藤慶輔、渡邉有希子、伊藤真輝、高江洲昇、坂本健太郎、石塚真由美 2016

[学会発表] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価

野見山桂、山本恭央、水川葉月、江口哲史、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介 2016

[学会発表] 非実験動物における化学物質代謝能の特徴と種差

池中良徳、筧麻友、水川葉月、中山翔太、石塚真由美 2016

[学会発表] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~.

Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka. 2016

[学会発表] Risk Assessment of Heavy Metals via Consumption of Muscle and Offal of Free-Range Animals from Benin City

Emmanuel Temiotan Ogbomida, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Isioma Tongo, Alex Ajeh Enuneku, Ogbeide Ozekeke, Martins Oshioriamhe Ainerua, Iriagbonse Priscillia Fasipe, Lawrence Ikechukwu Ezemonye, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka 2016

[学会発表] ハリネズミは化学物質高感受性種？ African hedgehog (Atalerix albiventris)で観察された低薬物代謝能

アクソルンサエンティエンチャイ、池中良徳、ネスタサム、ウスマジャムナーク、水川葉月、中山翔太、石塚真由美 2016

[学会発表] A glycomics approach to renal biomarkers in birds.

Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka 2016

[学会発表] 鳥類における新規腎障害マーカーの探索

石井千尋、池中良徳、市居修、中山翔太、西村紳一郎、大橋哲、田中誠一、齊藤慶輔、渡邊有希子、水川葉月、石塚真由美 2016

[学会発表] Human health risk due to polycyclic　aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites.

Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Kwadwo A. Asante, Christian Obirikorang, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka. 2016

[学会発表] Omics approach of proteomic and metabolomic analysis for PCBs toxicity in the dog brain

Kohki Takaguchi, Kei Nomiyama, Lauan M. Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe 2015

[学会発表] Diet records in winter, migration and diving behavior during early summer of juvenile Steller sea lions in the asian stock

Keizo Ito, Nao Takahashi, Kaoru Hattori, Yoko Goto, Takuya Nakanowatari, Kay I. Ohshima, Takanori Horimoto, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka, Kazushi Miyashita, Yoko Mitani 2015

[学会発表] Phase II酵素の欠損動物と非欠損動物―新たな動物種マッピング―

池中良徳, Aksorn Saengtienchai, 筧麻友, Wageh Sobhy Darwish, 水川葉月,中山翔太, 石塚真由美 2015

[学会発表] 第II相抱合反応の種差：食肉目におけるグルクロン酸抱合酵素の進化と遺伝子構造

池中良徳、筧麻友、中山翔太、川合佑典、渡邊研右、水川葉月、野見山桂、田辺信介、石塚真由美 2015

[学会発表] HCH’s in two fish species from a large floodplain pan within a subtropical conservation area

Clare Edwards, Yoshinori Ikenaka, Yared Beyene, Shouta MM. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka, Victor Wepener, Johan .H.J. van Vuren 2015

[学会発表] Vector-controlling pesticides in free-ranging chickens in KwaZulu-Natal, South Africa

Lesa A Thompson, Yoshinori Ikenaka, Johannes J van Vuren, Victor, Wepener, Nico Smit, Wynand Vlok, Yared B Yohannes, Hazuki Mizukawa, Shouta M M. Nakayama, Mayumi Ishizuka 2015

[学会発表] Lead poisoning and source identification in raptors from Japan

Chihiro Ishii, Shouta M.M. Nakayama, Yoshinori Ikenaka, Hazuki Mizukawa, Yared B. Yohannes, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Yasushi Masuda, Kentaro Q. Sakamoto, Mayumi Ishizuka 2015

[学会発表] Concentrations of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in domestic animal in Kumasi, Ghana

Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Jemima Marfo, Hazuki Mizukawa, Mayumi Ishizuka 2015

[学会発表] Phase II xenobiotic metabolizm in carnivora -UGT activity and genomestructure in Pinniped species-

Yoshinori Ikenaka, Mayu Kakehi, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka 2015

[学会発表] Exposure levels of polycyclic aromatic hydrocarbons (PAHs) and heavy metals in wild rats in　Kumasi, Ghana

Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Yared Beyene Yohannes, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa and Mayumi Ishizuka 2015

[学会発表] Tracing migration of northern fur seals in Russian-Japanese waters using stable isotopes in whiskers

Ayako Yamada, Takanori Horimoto, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka, Yoko Mitani, Kazushi Miyashita 2015

[学会発表] Vector-control pesticides disseminating via international waterways to accumulate in free-ranging freshwater and marine fish species

Lesa A Thompson, Yoshinori Ikenaka, Johannes J van Vuren, Victor, Wepener, Nico Smit, Wynand Vlok, Yared B. Yohannes, Hazuki Mizukawa, Shouta M.M. Nakayama, Mayumi Ishizuka 2015

[学会発表] Assessment of exposure to toxic elements (As, Pb, Cd and Hg), and DDTs in four species of birds from Ethiopia

Yared Beyene Yohannes, Yoshinori Ikenaka, Shouta MM. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka 2015

[学会発表] ウマにおけるシトクロムP450の特性評価：ジアゼパム代謝を担うCYP3Aの重要性

水川葉月、中山翔太、池中良徳、速水秋、Wageh Sobhy Darwish、渡邊研右、川合佑典、石塚真由美 2015

[学会発表] Metallothionein as a biomarker for chicken exposure to heavy metals

Wageh S. Darwish, Walaa F. Saad Eldin, Nesta Bortey-Sam, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka 2015

[学会発表] Metabolism and biotransformation of organohalogen compounds in the liver microsomes of cats and dogs

Hazuki Mizukawa, Kei Nomiyama, Nozomu, Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama,Misaki Maehara, Shinsuke Tanabe, Mayumi Ishizuka 2015

[学会発表] 抗血液凝固系殺鼠剤の標的分子であるビタミンKエポキシド還元酵素(VKOR)の鳥類における特徴及び種差

森田鮎子、池中良徳、中山翔太、石井千尋、水川葉月、渡邉研右、齊藤慶輔、渡邊有希子、伊藤真輝、高江洲昇、石塚真由美 2015

[学会発表] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats: effects on thyroid hormones homeostasis

Yasuo Yamamoto, Kei Nomiyama, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Tatsuya Kunisue, Shinsuke Tanabe 2015

[学会発表] The habitat use of northern fur seals Callorhinus ursinus around northern Japan during non-breeding season, defined from stable isotopes and trace elements in whiskers

Takanori Horimoto, Svetlana Artemyeva, Peter Permyakov, Mari Kobayashi, Kaoru Hattori, Hiromi Kasai, Hiroshige Tanaka, Yoshinori Ikenaka, Shouta M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka, Vladimir Burkanov, Russel Andrews, Yoko Mitani, Yasunori Sakurai 2015

[学会発表] 野生齧歯類におけるワルファリン抵抗性獲得機序の解明

武田一貴、池中良徳、田中和之、中山翔太、谷川力、水川葉月、石塚真由美 2015

[学会発表] シンポジウム「野生鳥類の化学物質汚染とその影響」鳥類で起こっているケミカルハザードとそのメカニズム

中山翔太、水川葉月、池中良徳、石塚真由美 2015

[学会発表] 猛禽類における鉛中毒問題と骨における鉛分布の解明

石井千尋、中山翔太、池中良徳、水川葉月、中田北斗、森田鮎子、齊藤慶輔、渡邊有希子、神和夫、田辺信介、野見山桂、林光武、増田泰、坂本健太郎、石塚真由美 2015

[学会発表] Lead pollution in the children in Kabwe mining area, Republic of Zambia- Source identification by stable isotope analysis, 7th International Toxicology Symposium in Africa

Shouta M M Nakayama, John Yabe, Yoshinori Ikenaka, Yared Beyene Yohannes, Balazs Oroszlany, Nesta Bortey-Sam, Kaampwe Muzandu, Hazuki Mizukawa, Kenedy Choongo, Abel Kabalo, Aaron Mweene, Mayumi Ishizuka 2015

[学会発表] Nitrate content in Egyptian meat products and its modulatory effects on xenobiotic metabolizing enzymes

Wageh Sobhy Darwish，Mohamed Abdallah Hussein, Yoshinori Ikenaka，Shouta M.M. Nakayama，Hazuki Mizukawa, Mayumi Ishizuka 2015

[学会発表] Protective Effects of Carotenoids and Retinoids on Benzo[a]Pyrene Induced Mutagenicity and Oxidative Stress

Wageh Sobhy Darwish, Yoshinori Ikenaka，Shouta M.M. Nakayama，Hazuki Mizukawa, Mayumi Ishizuka 2015

[雑誌論文] Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meats

Darwish WS, Hussein MA, El-Desoky KI, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M 2015

[学会発表] Lead (Pb) poisoning in children from townships around an extensive lead-zinc mine in Kabwe, the Republic of Zambia

Shouta M.M. Nakayama, John Yabe, Yoshinori Ikenaka, Yared Beyene, Nesta Bortey-Sam, Balazs Oroszlany, Kaampwe Muzandu, Kennedy Choongo, Aaron Mweene, Abel Kabalo, Hazuki Mizukawa, Mayumi Ishizuka 2015

[学会発表] Vector-control pesticide DDT detected in free-ranging chickens from South Africa

Lesa A Thompson, Yoshinori Ikenaka, Yared B Yohannes, Johan van Vuren, Victor Wepener, Nico J Smit, Wynand Vlok, Shouta M M Nakayama, Hazuki Mizukawa and Mayumi Ishizuka 2015

研究成果