脂質非二重膜構造中における自発的分子認識機構の解明

トップ›研究者を探す›脂質非二重膜構造中における自発的分子認識機構の解明

代表研究者	松木均
研究課題番号	KAKENHI-PROJECT-15550122
研究種目	基盤研究(C)
研究分野	理工系化学複合化学機能物質化学
研究機関	徳島大学
研究分担者	金品昌志
研究期間開始年月日	2003/4/1
研究期間終了年度	2005
研究ステータス	完了 (2005/4/1)
配分額（合計）	3,800,000 (直接経費 :3,800,000)
配分額（履歴）	2005年度：700,000 (直接経費 :700,000) 2004年度：1,100,000 (直接経費 :1,100,000) 2003年度：2,000,000 (直接経費 :2,000,000)
キーワード	リン脂質脂質二重膜相転移非二重膜構造指組み構造ゲル相ヘキサゴナルII相高圧力分子認識相図コレステロール巨大ベシクル巨大単層ベシクル麻酔薬 Phospholipid Lipid bilayer membrane Phase transition Non-bilayer structure Interdigitated gel phase Hexagonal II phase High pressure Molecular recognition

研究成果

[雑誌論文] Bilayer Phase Transitions of N-methylated Dioleoylphosphatidyl-ethanolamines under High Pressure

M.Kusube, M.Goto, N.Tamai, H.Matsuki, S.Kaneshina 2006

[雑誌論文] Thermodynamics of Bilayer Phase Transitions of Phospholipids

H.Matsuki, S.Kaneshina 2006

[雑誌論文] Barotropic Phase Transition between the Liquid Crystal Phase and the Inverted Hexagonal II Phase of Dioleoylphosphatidyl-ethanolamine Bilayer Membrane

R.Sueyoshi, K.Tada, M.Goto, N.Tamai, H.Matsuki, S.Kaneshina 2006

[雑誌論文] リン脂質二分子膜相転移の熱力学

松木均 2006

[雑誌論文] Thermotropic and Barotropic Phase Transitions of N-methylated Dipalmitoylphosphatidylethanolamine Bilayers

M.Kusube, H.Matsuki, S.Kaneshina 2005

[雑誌論文] Comparative Study of Specific and Non-Specific Interactions between Bio-Macromolecules and Ligands

H.Matsuki, U.Komatsu, M.Nishimoto, S.Kaneshina, K.Ogli 2005

[雑誌論文] Dissociation Equilibrium between Uncharged and Charged Local Anesthetic Lidocaine in a Surface-Adsorbed Film

H.Matsuki, M.Yamanaka, H.Kamaya, S.Kaneshina, I.Ueda 2005

[雑誌論文] Lipid phase transitions controlled by pressure and temperature

S.Kaneshina, H.Matsuki 2005

[雑誌論文] Observation of the lipid bilayer phase transition using the amphiphilic ion sensor

N.Yamasaki, K.Matsuoka, K.Nagayama, T.Hata, H.Matsuki, H.Satake, S.Kaneshina 2005

[雑誌論文] Local Anesthetic Tetracaine Induces the Interdigitation of Lipid Bilayers

Shoji Kaneshina 2005

[雑誌論文] Partition Coefficients of Local Anesthetic into Phospholipid-Cholesterol Mixed Bilayer Membranes

K.Matsuoka, K.Nagayama, T.Hata, H.Satake, H.Matsuki, S.Kaneshina 2005

[雑誌論文] Effect of Deuterium Oxide on the Thermodynamic Quantities Associated with Phase Transitions of Lipid Bilayer Membranes

H.Matsuki, H.Okuno, F.Sakano, M.Kusube, S.Kaneshina 2005

[雑誌論文] Local Anesthetic Tetracaine Induces the Interdigitation of Lipid Bilayers

S.Kaneshina, H.Matsuki, T.Hata, H.Okuno, M.Kusube, N.Tamai 2005

[雑誌論文] Distribution of Charged and Uncharged Local Anesthetic into Phospholipid Bilayer Membrane-Correlation between Partition Coefficients and Anesthetic Potency-

N.Yamasaki, K.Matsuoka, M.Nishimoto, T.Hata, H.Satake, H.Matsuki, S.Kaneshina 2005

[雑誌論文] 圧力と温度による脂質の相転移制御

金品昌志 2005

[雑誌論文] Effect of Cholesterol on Partition Coefficients of Local Anesthetic into Lipid Bilayer Membranes of Dimyristoylphosphatidylcholine

K.Matsuoka, Y.Tanioka, T.Hata, H.Matsuki, H.Satake, S.Kaneshina 2005

[雑誌論文] Barotropic Phase Transitions of 1-Palmitoyl-2-stearoyl-phos-phatidylcholine Bilayer Membrane

H.Matsuki, M.Goto, M.Kusube, N.Tamai, S.Kaneshina 2005

[雑誌論文] Pressure-Induced Phase Transitions of Lipid Bilayers Observed by Fluorescent Probes Prodan and Laurdan

M.Kusube, N.Tamai, H.Matsuki, S.Kaneshina 2005

[雑誌論文] Partition Coefficients of Local Anesthetic into Lipid Bilayer Membranes containing unsaturated acyl chain

M.Nishimoto, K.Nagayama, T.Hata, H.Matsuki, H.Satake, S.Kaneshina 2005

[雑誌論文] Recognition for Long-Chain Saturated Fatty Acids by Dipalmitoylphosphatidylcholine Bilayer Membranes

H.Matsuki, M.Kusube, N.Tamai, S.Kaneshina, H.Kamaya, I.Ueda 2005

[雑誌論文] Barotropic Phase Transitions of 1-Palmitoy1-2-stearoylphos-phatidylcholine Bilayer Membrane

Hitoshi Matsuki 2005

[雑誌論文] Barotropic Phase Transitions of 1-Palmitoyl-2-stearoylphosphatidylcholine Bilayer Membrane

Hitoshi Matsuki 2005

[雑誌論文] Effect of Deuterium Oxide on the Thermodynamic Quantities Associated with Phase Transitions of Lipid Bilayer Membranes

Hitoshi Matsuki 2005

[雑誌論文] Recognition for Long-Chain Saturated Fatty Acids by Dipalmitoylphosphatidylcholine Bilayer Membranes

Hitoshi Matsuki 2005

[雑誌論文] Dissociation Equilibrium between Uncharged and Charged Local Anesthetic Lidocaine in a Surface-Adsorbed Film

Hitoshi Matsuki 2005

[雑誌論文] Comparative Study of Specific and Non-Specific Interactions Between Bio-Macromolecules and Ligands

Hitoshi Matsuki 2005

[雑誌論文] Recognition for Long-Chain Saturated Fatty Acids by Dipalmitoylphos-phatidylcholine Bilayer Membranes

Hitoshi Matsuki 2005

[雑誌論文] Effect of Deuterium Oxide on the Thermodynamic Quantities Asscociated with Phase Transitions of Lipid Bilayer Membranes

Hitoshi Matsuki 2005

[雑誌論文] Preferential Partitioning of Uncharged Local Anesthetics into the Surface-Adsorbed Film

H.Matsuki, M.Yamanaka, H.Kamaya, S.Kaneshina, I.Ueda 2004

[雑誌論文] Model Study on Local Anesthetic Action-Elucidation of Action Mechanism by Surface-Chemical Methods-

H.Matsuki, H.Satake, S.Kaneshina 2004

[雑誌論文] Effect of Pressure on the Prodan Fluorescence in Bilayer Membranes of Phospholipids with Varying Acyl Chain Lengths

M.Kusube, H.Matsuki, S.Kaneshina 2004

[雑誌論文] 局所麻酔作用のモデル研究- 界面化学的手法による作業機構の解明-

松木均 2004

[雑誌論文] Preferential Partitioning of Uncharged Local Anesthetics into the Surface-Adsorbed Film

Hitoshi Matsuki 2004

[雑誌論文] Effect of head groups on the bilayer phase transitions of phospholipids under high pressure

M.Kusube, H.Matsuki, S.Kaneshina 2003

[雑誌論文] Effects of Cis and Trans Unsaturation on the Barotropic and Thermotropic Phase Behavior of Phospholipid Bilayers

Shoji Kaneshina 2003

[雑誌論文] Barotropic and Thermotropic Phase Behavior of Bilayer Membranes Composed of Phospholipids Containing Cis Double Bond in the sn-2 Acyl Chain

H.Matsuki, M.Kusube, T.Hata, S.Kaneshina 2003

[雑誌論文] Effects of Cis and Trans Unsaturation on the Barotropic and Thermotropic Phase Behavior of Phospholipid Bilayers

S.Kaneshina, H.Matsuki, M.Kusube, H.Ichimori 2003

[雑誌論文] Partition Coefficients of Local Anesthetic Dibucaine into the Lipid Bilayer Membrane Determined by a Dibucaine Cation Sensor

M.Nishimoto, K.Matsuoka, K.Nagayama, T.Hata, H.Matsuki, H.Satake, S.Kaneshina 2003

[雑誌論文] Recognition for Long-Chain Fatty Acids by Dipalmitoylphosphatidylcholine Bilayer Membranes

H.Matsuki, M.Kusube, S.Kaneshina, H.Kamaya, I.Ueda 2003

[雑誌論文] Anesthetic Receptivity of Lipid Membranes with Different Bilayer Phases

T.Hata, K.Matsuoka, K.Ito, H.Matsuki, H.Satake, S.Kaneshina 2003

[雑誌論文] Effects of Pressure and Hydrophobic Chain Length on the Interdigitation of Phospholipid Bilayer Membranes

H.Matsuki, F.Sakano, T.Hata, H.Ichimori, S.Kaneshina 2003

[雑誌論文] ジバルミトイルホスファチジルコリン二分子膜の長鎖脂肪酸認識

松木均 2003

[雑誌論文] Barotropic and Thermotropic Phase Behavior of Bilayer Membranes Composed of Phospholipids Containing Cis Double Bond in the sn-2 Acyl Chain

Hitoshi Matsuki 2003

[雑誌論文] リン脂質二分子膜の指組み構造形成におよぼす圧力と疎水基鎖長の影響

松木均 2003