研究成果

[学会発表] ネズミマラリア原虫赤血球侵入リガンドEBL領域4 の機能解析

大槻均，菅井千明，近藤陽子，入子英幸，石野智子，金子修，坪井敬文，鳥居本美 2016

[学会発表] WGCFS: an innovative technology expressing quality proteins for the post-genome malaria vaccine candidate discovery

Tsuboi T 2016

[学会発表] Isolation method of invasive Plasmodium yoelii merozoites with a long half-life to evaluate erythrocyte invasion dynamics and potential invasion inhibitors

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O 2016

[学会発表] Plasmodium yoelii遺伝子を標的としたテトラサイクリン発現誘導システムの確立

外川裕人、麻田正仁、矢幡一英、金子修 2016

[学会発表] Tet-Onによる遺伝子コンディショナルノックアウト法の開発

麻田正仁、外川裕人、矢幡一英、金子修 2016

[学会発表] Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor

Pandey K, Ferreira PE, Ishikawa T, Kaneko O, Yahata K 2016

[学会発表] マラリア原虫の膜タンパク質輸送マシーナリーの解析

宮崎真也, 加賀谷渉, Zhu X, Chitama B, 矢幡一英, 金子修 2016

[学会発表] マラリア原虫のRab5b GTPaseは寄生胞膜の感染赤血球側に運ばれる

海老根一生，平井智浩, 平井誠，坂口美亜子，矢幡一英，金子修，野崎智義, 中野由美子 2016

[学会発表] The tryptophan-rich domain of Plasmodium falciparum SURFIN4.2 is required for its transport from Maurer’s clefts to the surface of red blood cell

Miyazaki S, Kagaya W, Yahata K, Ohta N, Kaneko O 2016

[学会発表] Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor

Yahata K, Pandey K, Ferreira PE, Ishikawa T, Kaneko O 2016

[学会発表] 誘電泳動現象を活用した赤血球変形能計測デバイスの開発

額賀正行、矢口友幸、Kim SooHyeon、矢幡一英、藤井輝夫、金子修、木村啓志 2016

[学会発表] 誘電泳動現象を用いた赤血球の変形能計測デバイス

額賀正行、矢口友幸、金秀炫、矢幡一英、藤井輝夫、金子修、木村啓志 2016

[学会発表] 熱帯熱マラリア原虫SURFIN4.2の細胞内領域はマウレル裂から赤血球表面への輸送に必要である

加賀谷渉、宮崎真也、矢幡一英、太田伸生、金子修 2016

[雑誌論文] Immunoprofiling of the tryptophan-rich antigen family in Plasmodium vivax

Wang B, Lu F, Cheng Y, Chen JH, Jeon HY, Ha KS, Cao J, Nyunt MH, Han JH, Lee SK, Kyaw MP, Sattabongkot J, Takashima E, Tsuboi T, Han ET 2015

[雑誌論文] Rodent malaria lactate dehydrogenase assay provides a high throughput solution for in vivo vaccine studies

Otsuki H, Yokouchi Y, Iyoku N, Tachibana M, Tsuboi T, Torii M 2015

[雑誌論文] Discovery of novel Plasmodium falciparum pre-erythrocytic antigens for vaccine development

Aguiar JC, Bolton J, Wanga J, Sacci JB, Iriko H, Mazeika JK, Han ET, Limbach K, Patterson NB, Sedegah M, Cruz AM, Tsuboi T, Hoffman SL, Carucci D, Hollingdale MR, Villasante ED, Richie TL 2015

[学会発表] Identification of Plasmodium falciparum PfMAS170 as novel blood-stage malaria vaccine candidate

Takashima E, Sasaoka C, Sakamoto H, Ito D, Takeo S, Sattabongkot J, Tsuboi T 2015

[学会発表] ポストゲノムマラリアワクチン研究は宿主寄生体関係の総体的理解につながる

坪井敬文 2015

[学会発表] Coevolution of cellular metabolic systems and mitochondria carrier-type membrane transporters

Tozawa Y, Nozawa A, Tsuboi T 2015

[学会発表] An integrated approach to tackling malaria in Uganda with special reference to novel malaria vaccine candidate discovery

Tsuboi T, Kanoi BN, Egwang TG, Horii T 2015

[学会発表] WGCFS: an innovative technology for post-genome malaria vaccine research

Tsuboi T 2015

[雑誌論文] Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum

Kapulu MC, Da DF, Miura K, Li Y, Blagborough AM, Churcher TS, Nikolaeva D, Williams AR, Goodman AL, Sangare I, Turner AV, Cottingham MG, Nicosia A, Straschil U, Tsuboi T, Gilbert SC, Long CA, Sinden RE, Draper SJ, Hill AVS, Cohuet A, Biswas S 2015

[学会発表] Identification of a strain transcending blood-stage malaria vaccine candidate against Plasmodium falciparum among four novel blood-stage antigens

Ntege EH, Arisue N, Ito D, Hasegawa T, Palacpac NMQ, Horii T, Takashima E, Tsuboi T 2015

[雑誌論文] Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China.

Feng H, Gupta B, Wang M, Zheng W, Zheng L, Zhu X, Yang Y, Fang Q, Luo E, Fan Q, Tsuboi T, Cao Y, Cui L 2015

[雑誌論文] Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization

Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M, Tsuboi T 2015

[学会発表] Functional analyses of sporozoite rhoptry proteins of Plasmodium berghei during target cell invasion

Ishino T, Sugino Y, Nozaki M, Murata E, Tokunaga N, Tachibana M, Tsuboi T, Torii M 2015

[学会発表] Pre-erythrocytic vaccines for malaria elimination

Tsuboi T 2015

[学会発表] Proteins in dense granules of malaria merozoite are responsible for the modification of parasitophorous vacuole essential for the parasitism

Morita M, Takashima E, Ito D, Iimura T, Torii M, Tsuboi T 2015

[学会発表] Genome-wide immunoscreening of antibodies responsible for Plasmodium falciparum growth inhibitory activity of Malian adult IgG

Morita M, Takashima E, Kanoi BN, Miura K, Long CA, Tsuboi T 2015

[学会発表] バベシア原虫メロゾイトの宿主赤血球遊出機構

麻田正仁, Mossaad E, Hakimi H, 矢幡一英, 河津信一郎, 金子修 2015

[学会発表] Isolation method of invasive Plasmodium yoelii merozoites with a long half-life to evaluate erythrocyte invasion dynamics and potential invasion inhibitors

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O 2015

[学会発表] 熱帯熱マラリア原虫SURFIN4.2のトリプトファン豊富領域はマウレル裂から赤血球表面への輸送に必要である

加賀谷渉、宮崎真也、矢幡一英、太田伸生、金子修 2015

[学会発表] Development of Tet-On-based conditional gene knockout system for rodent malaria parasite Plasmodium yoelii

Asada M, Kegawa Y, Yahata K, Kaneko O 2015

[学会発表] Calcium monitoring in Plasmodium falciparum through Yellow Cameleon-Nano Biosensors

Yahata K, Pandey K, Ferreira PE, Ishikawa T, Kaneko O 2015

[学会発表] On-chip deformability measurement of malaria parasite-infected red blood cells by dielectrophoretic force

Nukaga M, Kim SH, Yahata K, Fujii T, Kaneko O, Kimura H 2015

[学会発表] Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1

Asada M, Yahata K, Hakimi H, Yokoyama N, Igarashi I, Kaneko O, Suarez CE, Kawazu S-I 2015

[学会発表] Transport and localisation of Plasmodium knowlesi Skeletal Binding Protein 1 (SBP1) in infected monkey and human erythrocytes

Lucky AB, Sakaguchi M, Katakai Y, Kawai S, Yahata K, Templeton T, Kaneko O 2015

[学会発表] 熱帯熱マラリア原虫の輸送タンパク質

宮崎 真也 ，加賀谷渉 ，Xiaotong Zhu，矢幡一英 ，金子修 2015

[学会発表] Transport and localisation of Plasmodium knowlesi Skeletal Binding Protein 1 (SBP1) in infected monkey and human erythrocytes

Lucky AB, Sakaguchi M, Katakai Y, Kawai S, Yahata K, Templeton T, Kaneko O 2015

[学会発表] マラリア原虫による寄生赤血球の改変

Lucky, A、坂口美亜子、宮崎真也、加賀谷渉、片貝祐子、川合覚、矢幡一英、Templeton T、金子修 2015

[学会発表] Identification of the proteins interacting with Plasmodium falciparum SURFIN that is exported to the parasite-infected red blood cell

Miyazaki S, Kagaya W, Zhu X, Chitama B, Yahata K, Kaneko O 2015

[学会発表] Characterization of Plasmodium vivax subtelomeric transmembrane protein

Sungkapong T, Kaewthamasorn, Yahata K, Chotivanich K, Kaneko O 2015

[学会発表] 感染赤血球へのタンパク質輸送に必須なマラリア原虫分子の探索

宮崎真也, 加賀谷渉, Zhu X, Chitama B, 矢幡一英, 金子修 2015

[学会発表] 熱帯熱マラリア原虫SURFIN4.2 のマウレル裂から赤血球表面への輸送機構

加賀谷渉, 宮崎真也, 矢幡一英, 太田伸生, 金子修 2015

[学会発表] Ca2+ monitoring in Plasmodium falciparum cytosol through yellow cameleon-Nano biosensors

Yahata K, Pandey K, Ferreira PE, Ishikawa T, Kaneko O 2015

[学会発表] Plasmodium yoelii 赤血球内侵入型原虫を標的としたテトラサイクリン発現誘導システムの確立

外川裕人, 麻田正仁, 矢幡一英, 金子修 2015

[学会発表] マラリア原虫による感染赤血球へのタンパク質輸送

宮崎真也, 加賀谷渉, Zhu X, Chitama B, 矢幡一英, 金子修 2015

[雑誌論文] Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery

Arumugam TU, Ito D, Takashima E, Tachibana M, Ishino T, Torii M, Tsuboi T 2014

[学会発表] ネズミマラリア原虫 Plasmodium yoelii のAMA1はメロゾイトの形態変化にともない放出される

矢幡一英、Mutungi JK、坪井敬文、金子修 2014

[雑誌論文] Tricomponent complex loaded with a mosquito-stage antigen of the malaria parasite induces potent transmission-blocking immunity

Arakawa T, Tsuboi T, Sattabongkot J, Sakao K, Torii M, Miyata T 2014

[雑誌論文] Profiling the humoral immune responses to Plasmodium vivax infection and identification of candidate immunogenic rhoptry-associated membrane antigen (RAMA)

Lu F, Li J, Wang B, Cheng Y, Kong DH, Cui L, Ha KS, Sattabongkot J, Tsuboi T, Han ET 2014

[雑誌論文] Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10

Cheng Y, Wang B, Sattabongkot J, Lim CS, Tsuboi T, Han ET 2014

[学会発表] 熱帯熱マラリア原虫タンパク質PfH04はメロゾイトの赤血球侵入に関与する

笹岡 千紗、伊藤 大輔、Sattabongkot Jetsumon、鳥居 本美、高島 英造、坪井 敬文 2014

[学会発表] 熱帯熱マラリア原虫メロゾイトのロプトリー頸部タンパク質RON12による原虫増殖阻害抗体の誘導

伊藤 大輔、高島 英造、畑野 晋也、山崎 勤、長谷川 倫之、三浦 憲豊、Thongkukiatkul Amporn、Sattabongkot Jetsumon、鳥居 本美、坪井 敬文 2014

[学会発表] Characterization of PyRON5, a Plasmodium yoelii rhoptry neck protein.

Mutungi JK, Yahata K, Sakaguchi M, Culleton R, Kaneko O. 2014

[学会発表] Characterization of PyRON5, a Plasmodium yoelii rhoptry neck protein.

Mutungi JK, Yahata K, Sakaguchi M, Culleton R, Kaneko O. 2014

[雑誌論文] A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut.

Mathias DK, Pastrana-Mena R, Ranucci E, Ferruti P, de Beaumont C, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Verotta L, Dinglasan RR 2013

[雑誌論文] The Plasmodium vivax merozoite surface protein 1 paralog is a novel erythrocyte-binding ligand of P. vivax.

Cheng Y, Wang Y, Ito D, Kong DH, Ha KS, Chen JH, Lu F, Li J, Wang B, Takashima E, Sattabongkot J, Tsuboi T, Han ET. 2013

[雑誌論文] Characterization of a novel merozoite surface protein of Plasmodium vivax, Pv41.

Cheng Y, Lu F, Tsuboi T, Han ET. 2013

[学会発表] 熱帯熱マラリア原虫メロゾイトの新規デンスグラニュール分子の同定

坪井敬文 2013

[学会発表] マラリア原虫が赤血球に侵入する際の細胞内オルガネラタンパク質の局在変化

矢幡一英，Mutungi JK、坪井敬文、金子　修 2013

[雑誌論文] Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJI, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG. 2013

[雑誌論文] Identification and characterization of the Plasmodium falciparum RhopH2 ortholog in Plasmodium vivax.

Wang B, Lu F, Cheng Y, Li J, Ito D, Sattabongkot J, Tsuboi T, Han ET. 2013

[学会発表] 赤血球侵入時におけるマラリア原虫タンパク質の時間空間的な局在解析

矢幡一英，Mutungi Joe Kimanthi，坪井敬文，金子　修 2013

[学会発表] 熱帯熱マラリア発病阻止ワクチン候補抗原のゲノム網羅的探索

坪井敬文 2013

[学会発表] Imaging of the molecular dynamics of malaria antigens during erythrocyte invasion

Mutungi JK，Yahata K, Kaneko O 2013

[学会発表] トキソプラズマやマラリアが持つ植物液胞様オルガネラ

福士路花，矢幡一英，佐倉孝哉，金子　修，永宗喜三郎 2013

[学会発表] 熱帯熱マラリア原虫タンパク質SURFINの赤血球への輸送機構

宮崎真也，Zhu Xiaotong，矢幡一英，金子　修 2013

[学会発表] The upstream sequence segment of the C-terminal cysteine-rich domain is required for microneme trafficking of Plasmodium falciparum erythrocyte binding antigen 175

佐倉孝哉，矢幡一英，金子　修 2013

[学会発表] 赤内期熱帯熱マラリア原虫SURFIN4.2のマウレル裂から赤血球表面への輸送機構

加賀谷　渉，宮崎真也，矢幡一英，太田伸生，金子　修 2013

[学会発表] 機能予測に基づくポストゲノム熱帯熱マラリア赤血球期ワクチン候補抗原の探索

坪井敬文 2012

[学会発表] Identification of GAMA as a multi-stage malaria vaccine candidate

坪井敬文 2012

[学会発表] マラリア原虫感染赤血球に輸送されるPf332分子の局在について

Jiang N, 坂口美亜子, Alexandre J, 矢幡一英, 坪井敬文, Chen Q, 金子修 2012

[学会発表] コムギ無細胞系を利用したヒト/マラリア原虫タンパク質相互作用のゲノムワイド探索の試み

坪井敬文 2012

[学会発表] Application of cell-free protein synthesis technology for production of malaria protein

坪井敬文 2012

[学会発表] RALP1 is localized at rhoptry neck of Plasmodium falciparum merozoite and translocates to moving junction

坪井敬文 2012

[学会発表] マラリア原虫メロゾイトの赤血球侵入におけるロプトリー頸部分子RALP1の機能解析

坪井敬文 2012

[学会発表] Molecular characterization of hypothetical Plasmodium falciparum protein, PfH04

坪井敬文 2012

[学会発表] マラリア原虫赤血球結合リガンドEBLのマイクロネーム輸送に必要な配列の同定

佐倉孝哉、矢幡一英、金子修 2012

[学会発表] Recombinant Plasmodium falciparum SURFIN_<4.1> protein is exported to the parasite-infected red blood cell

Zhu X, Yahata K, Alexandre JSF, Kaneko O 2012

[学会発表] マラリア原虫赤血球結合リガンドEBLのマイクロネーム輸送に必要な配列の同定

佐倉孝哉、矢幡一英、金子修 2012

[学会発表] Identification of a region responsible for Plasmodium falciparum Pf332 export to the infected erythrocyte

Jiang N, Alexandre J, Yahata K, Tsuboi T, Chen Q, Kaneko O 2011

[学会発表] Transmembrane region of Plasmodium falciparum antigen 332 is essential for the transport to the Maurer's clefts in the parasite-infected red blood cell

Jiang N, Sakaguchi M, Alexandre JSF, Yahata K, Tsuboi T, Chen Q, Kaneko O 2011

[学会発表] Identification of a region responsible for Plasmodium falciparum Pf332 export to the infected erythrocyte

Jiang N, Alexandre J, Yahata K, Tsuboi T, Chen Q, Kaneko O 2011

[学会発表] Trafficking of Erythrocyte-Binding-Antigen 175 (EBA175) in Plasmodium falciparum

Sakura T, Yahata K, Kaneko O 2011

[学会発表] PEXEL-independent exportation of Plasmodium falciparum proteins into the parasite-infected red blood cell and Maurer's clefts

Kaneko O, Alexandre JSF, Jiang N, Sakaguchi M, Yahata K 2011

[学会発表] Recombinant Plasmodium falciparum SURFIN_<4.1> protein is exported to the parasite-infected red blood cell

Zhu X, Yahata K, Alexandre JSF, Kaneko O 2011

[学会発表] Recombinant Plasmodium falciparum SURFIN_<4.1> protein is exported to the parasite-infected red blood cell

Zhu X, Yahata K, Alexandre JSF, Kaneko O 2011

[学会発表] マラリア原虫赤血球結合リガンドEBLの細胞内輸送

佐倉孝哉、矢幡一英、金子修 2011

[学会発表] Antibodies against a Plasmodium falciparum rhoptry neck protein PfRON12 inhibit merozoite invasion into erythrocytes

Ito D, Takashima E, Hatano S, Yamasaki T, Hasegawa T, Miura K, Thongkukiatkul A, Long CA, Sattabongkot J, Torii M, Tsuboi T 0

[学会発表] ネズミマラリア原虫赤血球侵入リガンドEBL 領域3-5の機能解析

大槻均、菅井千明、入子英幸、石野 智子、金子修、福本宗嗣、坪井敬文、鳥居本美 0

[学会発表] Immunoscreening of the target proteins contributing to growth inhibitory activity of human IgG against Plasmodium falciparum

Morita M, Takashima E, Kanoi BN, Miura K, Tsuboi T 0

[学会発表] Profiling the humoral immune responses to Plasmodium vivax infection and identification of candidate immunogenic rhoptry-associated membrane antigen

Lu F, Li J, Wang B, Cheng Y, Kong DH, Cui L, Ha KS, Sattabongkot J, Tsuboi T, Han ET 0

[学会発表] Wheat germ cell-free protein synthesis system (WGCFS): a breakthrough for the post-genome vivax malaria research

Tsuboi T, Takashima E, Ito D, Feng Lu, Cheng Y, Han ET 0

[学会発表] Identification of the novel transmission-blocking vaccine target expressing on the surface of male gametes

Tachibana M, Torii M, Sudo M, Tsuboi T, Ishino T 0

[学会発表] Characterization of Plasmodium falciparum MAS170 as novel malaria blood-stage vaccine candidate

Sasaoka C, Sakamoto H, Ito D, Takeo S, Sattabongkot J, Takashima E, Tsuboi T 0

[学会発表] ネズミマラリア原虫 Plasmodium yoelii のAMA1 はメロゾイトの形態変化にともない放出される

矢幡一英, Mutungi JK, 坪井敬文, 金子修 0

[学会発表] Characterization of Plasmodium falciparum MAS170 as novel malaria blood-stage vaccine candidate

Sasaoka C, Sakamoto H, Ito D, Takeo S, Sattabongkot J, Takashima E, Tsuboi T 0

[学会発表] 熱帯熱マラリア原虫の輸送タンパク質SURFIN が形成する複合体の性状解析

宮崎真也, Zhu X, 加賀谷渉, 矢幡一英, 金子修 0

[学会発表] Isolation of viable and invasive Plasmodium yoelii merozoite

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O 0

[学会発表] 熱帯熱マラリア原虫の輸送タンパク質SURFINの輸送機構の解明

宮崎真也, Zhu Xiaotong，加賀谷渉、矢幡一英，金子修 0

[学会発表] 熱帯熱マラリア原虫SURFIN のマウレル裂から赤血球表面への輸送機構

加賀谷渉, 宮崎真也, 矢幡一英, 太田伸生, 金子修 0

[学会発表] Characterization of PyRON5, a Plasmodium yoelii rhoptry neck protein

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O 0