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三宅一央

徳島大学

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2024年4月25日更新

職名: 特任助教
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学位: 博士(医学)
職歴・経歴: 2007/5: 徳島大学医員, 病院 (-2007.9.)
2011/1: 徳島大学医員, 病院 (-2012.3.)
2012/4: 徳島大学助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学助教, 大学院医歯薬学研究部 (-2017.3.)
2020/4: 徳島大学助教, 大学院医歯薬学研究部 (-2021.3.)
2021/4: 徳島大学医員, 病院 (-2021.8.)
2021/9: 徳島大学特任助教, 大学院医歯薬学研究部

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2024年4月25日更新

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担当経験のある授業科目: 神経・精神・行動コース (学部)
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2024年4月25日更新

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論文

Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia and Parkinson's disease.,
Scientific Reports, Vol.13, No.1, 2023.

(要約): Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms.
(キーワード): Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus
(徳島大学機関リポジトリ): ● Metadata: 118394
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-37833-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081; ● Search Scopus @ Elsevier (PMID): 37420081; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3

(徳島大学機関リポジトリ: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081) Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki, Masafumi Harada and Yasushi Takagi :
Obsessivecompulsive symptoms are negatively correlated with motor severity in patients with generalized dystonia,
Scientific Reports, Vol.12, No.1, 20350, 2022.

(要約): We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). "Checking" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ϱ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ϱ = 0.72, p = 0.023; left: ϱ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia.
(キーワード): Humans / Dystonia / Retrospective Studies / Dystonic Disorders / Heredodegenerative Disorders, Nervous System
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-022-24826-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36437372; ● Search Scopus @ Elsevier (PMID): 36437372; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-24826-x

(DOI: 10.1038/s41598-022-24826-x, PubMed: 36437372) Kenji Shimada, Kazuhisa Miyake, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of Utilizing Both 3-Dimensional Multimodal Fusion Image and Intra-Arterial Indocyanine Green Videoangiography in Cerebral Arteriovenous Malformation Surgery,
World Neurosurgery, Vol.169, e260-e269, 2022.

(要約): An understanding of the complex morphology of an arteriovenous malformation (AVM) is important for successful resection. We have previously reported the utility of intra-arterial indocyanine green (ICG) videoangiography for this purpose, but that method cannot detect the angioarchitecture covered by brain tissue. 3-dimensional (3D) multimodal fusion imaging is reportedly useful for this same purpose, but cannot always visualize the exact angioarchitecture due to poor source images and processing techniques. This study examined the results of utilizing both techniques in patients with AVMs. Both techniques were applied in 12 patients with AVMs. Both images were compared with surgical views and evaluated by surgeons. Although evaluations for identifying superficial feeders by ICG videoangiography were high in all cases, the more complicated the AVM, the lower the evaluation by 3D multimodal fusion imaging. Conversely, evaluation of the estimated range of the nidus was high in all cases by 3D multimodal fusion imaging, but low in all but one case by ICG videoangiography. Nidus flow reduction was recognized by Flow 800 analysis obtained after ICG videoangiography. These results showed that utilizing both techniques together was more useful than each modality alone in AVM surgery. This was particularly effective in identifying superficial feeders and estimating the range of the nidus. This technique is expected to offer an optimal tool for AVM surgery.
(徳島大学機関リポジトリ): ● Metadata: 118079
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2022.10.121
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36332776; ● Search Scopus @ Elsevier (PMID): 36332776; ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2022.10.121

(徳島大学機関リポジトリ: 118079, DOI: 10.1016/j.wneu.2022.10.121, PubMed: 36332776) Kenji Shimada, Izumi Yamaguchi, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of intraarterial indocyanine green videoangiography in surgery for arteriovenous fistula at the craniocervical junction in a hybrid operating room: illustrative cases,
Journal of Neurosurgery. Case Lessons, Vol.3, No.23, 1-6, 2022.

(要約): Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Case 1 involved a 71-year-old man presenting with tetraparesis after sudden onset of severe headache due to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) demonstrated CCJ epidural AVF. Intraarterial ICG videoangiography revealed the drainer, which had been difficult to identify. The AVF disappeared after disconnection of the drainer. Case 2 involved a 68-year-old man presenting with severe headache due to SAH. DSA showed multiple AVFs at the CCJ and cerebellar tentorium. Intraarterial ICG videoangiography demonstrated concomitant perimedullary AVF and dural AVF at the CCJ. All AVFs disappeared postoperatively. Intraarterial ICG videoangiography was useful for definitive diagnosis of CCJ AVF, facilitating identification of feeders and drainers with bright and high phase contrast and allowing repeated testing to confirm flow direction.
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/CASE22100
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35733826; ● Search Scopus @ Elsevier (PMID): 35733826; ● Search Scopus @ Elsevier (DOI): 10.3171/CASE22100

(DOI: 10.3171/CASE22100, PubMed: 35733826) Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, 山本陽子, Kazutaka Kuroda and Yasushi Takagi :
Single-session hematoma removal and transcortical venous approach for coil embolization of an isolated transverse-sigmoid sinus dural arteriovenous fistula in a hybrid operating room: illustrative case,
Journal of Neurosurgery. Case Lessons, Vol.3, No.21, CASE2267, 2022.

(要約): Dural arteriovenous fistula (DAVF) can present with massive hematoma, which sometimes requires emergent removal. Therefore, a surgical strategy for single-session hematoma removal and shunt occlusion in the same surgical field is important. A 73-year-old man was transferred to the authors' hospital with a headache. Brain computed tomography (CT) revealed an intracerebral hematoma in the right temporoparietal lobe (hematoma volume 12 ml). A cerebral angiogram revealed a right isolated transverse-sigmoid sinus (TSS)-DAVF fed by the occipital artery and middle meningeal artery. There was cortical venous reflux into the Labbé vein and posterior parietal vein. Percutaneous transarterial and transvenous embolization were unsuccessful. The following day, his consciousness level acutely declined with a headache, and brain CT showed hematoma expansion (hematoma volume 41 ml) with a midline shift. Therefore, the authors performed single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF in a hybrid operating room. His postoperative course was uneventful. No recurrence was observed 3 months postoperatively on cerebral angiography. Single-session hematoma removal and a transcortical venous approach for coil embolization of an isolated TSS-DAVF is considered in cases with massive hematoma. This strategy is useful, considering recent developments in hybrid operating rooms.
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/CASE2267
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35734231; ● Summary page in Scopus @ Elsevier: 2-s2.0-85160834258

(DOI: 10.3171/CASE2267, PubMed: 35734231, Elsevier: Scopus) Kenji Shimada, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kazuhisa Miyake, Yoshiteru Tada, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi :
Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations,
World Neurosurgery, E1-E7, 2021.

(要約): Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs.
(徳島大学機関リポジトリ): ● Metadata: 116871
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.wneu.2021.08.118
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34478890; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115331132

(徳島大学機関リポジトリ: 116871, DOI: 10.1016/j.wneu.2021.08.118, PubMed: 34478890, Elsevier: Scopus) Ryoma Morigaki, Ryosuke Miyamoto, Taku Matsuda, Kazuhisa Miyake, Nobuaki Yamamoto and Yasushi Takagi :
Dystonia and cerebellum: From bench to bedside,
Life, Vol.11, No.8, 776, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116560
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11080776
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/life11080776

(徳島大学機関リポジトリ: 116560, DOI: 10.3390/life11080776) Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi :
Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia,
Life, Vol.11, No.6, 477, 2021.

(要約): Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.
(徳島大学機関リポジトリ): ● Metadata: 116561
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11060477
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34074009; ● Summary page in Scopus @ Elsevier: 2-s2.0-85107554331

(徳島大学機関リポジトリ: 116561, DOI: 10.3390/life11060477, PubMed: 34074009, Elsevier: Scopus) Daisy Ma Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, P Rollin Tabuena and Toshitaka Kawarai :
Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 400-403, 2021.

(要約): Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021.
(キーワード): Ataxia / Humans / Philippines / Siblings / Vitamin E Deficiency
(徳島大学機関リポジトリ): ● Metadata: 116574
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759169; ● Search Scopus @ Elsevier (PMID): 34759169; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.400

(徳島大学機関リポジトリ: 116574, DOI: 10.2152/jmi.68.400, PubMed: 34759169) Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto :
Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components.,
Brain Sciences, Vol.10, No.9, 636, 2020.

(要約): The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.
(徳島大学機関リポジトリ): ● Metadata: 116502
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci10090636
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724; ● Search Scopus @ Elsevier (PMID): 32942724; ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636

(徳島大学機関リポジトリ: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724) Kazuhisa Miyake, Ayuko Sakane, Ikuko Sagawa, Yoko Tomida, Jiro Kasahara and Takuya Sasaki :
Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains,
Scientific Reports, Vol.9, No.1, 12794, 2019.

(要約): JRAB/MICAL-L2 is an effector protein of Rab13, a member of the Rab family of small GTPase. JRAB/MICAL-L2 consists of a calponin homology domain, a LIM domain, and a coiled-coil domain. JRAB/MICAL-L2 engages in intramolecular interaction between the N-terminal LIM domain and the C-terminal coiled-coil domain, and changes its conformation from closed to open under the effect of Rab13. Open-form JRAB/MICAL-L2 induces the formation of peripheral ruffles via an interaction between its calponin homology domain and filamin. Here, we report that the LIM domain, independent of the C-terminus, is also necessary for the function of open-form JRAB/MICAL-L2. In mechanistic terms, two zinc finger domains within the LIM domain bind the first and second molecules of actin at the minus end, potentially inhibiting the depolymerization of actin filaments (F-actin). The first zinc finger domain also contributes to the intramolecular interaction of JRAB/MICAL-L2. Moreover, the residues of the first zinc finger domain that are responsible for the intramolecular interaction are also involved in the association with F-actin. Together, our findings show that the function of open-form JRAB/MICAL-L2 mediated by the LIM domain is fine-tuned by the intramolecular interaction between the first zinc finger domain and the C-terminal domain.
(キーワード): 3T3 Cells / Actins / Animals / Cytoskeleton / Hydrogen Deuterium Exchange-Mass Spectrometry / Mice / Microfilament Proteins / Models, Molecular / Mutation / Protein Domains / 構造活性相関 (structureactivity relationship) / Zinc Fingers
(徳島大学機関リポジトリ): ● Metadata: 114610
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-019-49232-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31488862; ● Summary page in Scopus @ Elsevier: 2-s2.0-85071764631

(徳島大学機関リポジトリ: 114610, DOI: 10.1038/s41598-019-49232-8, PubMed: 31488862, Elsevier: Scopus) Ayuko Sakane, Shin Yoshizawa, Masaomi Nishimura, Yuko Tsuchiya, Natsuki Matsushita, Kazuhisa Miyake, Kazuki Horikawa, Issei Imoto, Chiharu Mizuguchi, Hiroyuki Saito, Takato Ueno, Sachi Matsushita, Hisashi Haga, Shinji Deguchi, Kenji Mizuguchi, Hideo Yokota and Takuya Sasaki :
Conformational plasticity of JRAB/MICAL-L2 provides "law and order" in collective cell migration.,
Molecular Biology of the Cell, Vol.27, No.20, 3095-3108, 2016.

(要約): In fundamental biological processes, cells often move in groups, a process termed collective cell migration. Collectively migrating cells are much better organized than a random assemblage of individual cells. Many molecules have been identified as factors involved in collective cell migration, and no one molecule is adequate to explain the whole picture. Here we show that JRAB/MICAL-L2, an effector protein of Rab13 GTPase, provides the "law and order" allowing myriad cells to behave as a single unit just by changing its conformation. First, we generated a structural model of JRAB/MICAL-L2 by a combination of bioinformatic and biochemical analyses and showed how JRAB/MICAL-L2 interacts with Rab13 and how its conformational change occurs. We combined cell biology, live imaging, computational biology, and biomechanics to show that impairment of conformational plasticity in JRAB/MICAL-L2 causes excessive rigidity and loss of directionality, leading to imbalance in cell group behavior. This multidisciplinary approach supports the concept that the conformational plasticity of a single molecule provides "law and order" in collective cell migration.
(キーワード): Actinin / Animals / Cell Movement / Computational Biology / Dogs / Epithelial Cells / Focal Adhesions / HEK293 Cells / Humans / Madin Darby Canine Kidney Cells / Microfilament Proteins / Optical Imaging / Protein Binding / Protein Structure, Tertiary / Protein Transport / Tight Junctions / rab GTP-Binding Proteins
(徳島大学機関リポジトリ): ● Metadata: 114562
(出版サイトへのリンク): ● Publication site (DOI): 10.1091/mbc.E16-05-0332
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27582384; ● Search Scopus @ Elsevier (PMID): 27582384; ● Search Scopus @ Elsevier (DOI): 10.1091/mbc.E16-05-0332

(徳島大学機関リポジトリ: 114562, DOI: 10.1091/mbc.E16-05-0332, PubMed: 27582384) N Kawai, Kazuhisa Miyake, Y Yamamoto, Y Nishiyama, Y Maeda, Teruyoshi Kageji and T Tamiya :
Use of 11C-methinine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor,
Child's Nervous System, Vol.25, No.7, 845-853, 2009.

(要約): Prognosis of germinoma arising in the basal ganglia or thalamus is worse compared to that in the pineal or suprasellar region. One of the reasons for poor prognosis is the difficulty in evaluating the efficacy of treatment by conventional neuroimaging tools. PET STUDIES: The usefulness of (11)C-methionine (MET) positron emission tomography (PET) in monitoring the biological nature of brain tumors has been proved in glioma patients. Herein, we describe MET-PET findings in three cases of germinomas in the basal ganglia or thalamus and discuss the use of MET-PET in the assessment of treatment response and residual tumor for the next treatment strategy. The patients showed transient increase of MET uptake in the lesions after the initial treatment. Although we did not perform histological verification, MET- PET findings suggested that active tumor cells were still alive in the lesions after the initial treatment. MET uptake gradually decreased during the course of intensive therapy in these patients. MET-PET also revealed germinoma invasion in the brain before discernible signal abnormality or mass lesion in conventional magnetic resonance images in two patients. Further studies including histological verification and long-term follow-up might validate the use of MET-PET in monitoring the treatment efficacy and evaluation of active residual tumor after the treatment. Until we understand what MET uptake truly represents, treatment strategy based on MET uptake must be carefully designed to prevent overtreatment and resultant complications.
(キーワード): Adolescent / Antineoplastic Agents / Basal Ganglia / Brain Neoplasms / Carbon Radioisotopes / Child / Female / Germinoma / Humans / Magnetic Resonance Imaging / Male / Methionine / Neoplasm, Residual / Positron-Emission Tomography / Prognosis / Thalamus / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00381-009-0841-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19296116; ● Search Scopus @ Elsevier (PMID): 19296116; ● Search Scopus @ Elsevier (DOI): 10.1007/s00381-009-0841-7

(DOI: 10.1007/s00381-009-0841-7, PubMed: 19296116)

MISC

Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi :
Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series,
Operative Neurosurgery, Vol.25, No.3, 292-300, 2023.

(要約): Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery.
(キーワード): Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries
(出版サイトへのリンク): ● Publication site (DOI): 10.1227/ons.0000000000000796
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942; ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953

(DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus)

総説・解説: 研究者総覧に該当データはありませんでした。
講演・発表: Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Matsuda Taku, Hiroshi Koyama and Yasushi Takagi :
Long-term follow-up of 12 patients treated with bilateral pallidal stimulation for tardive dystonia,
13th Scientific meeting of Asian Australasian Society for Streotactic and Functional Neurosurgery, Osaka, Apr. 2023. OMAE Hiroshi, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, 中野渡友香, Megumi Kuno, Tetsuya Matsuura and Yasushi Takagi :
Cognitive changes due to subthalamic nucleus deep brain stimulation in elderly Parkinson's Disease,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
VM摘出術における3D multimodal fusion imageとindocyanine green動注による術中videoangiography併用の有用性,
第32回脳神経外科手術と機器学会(CNTT2023), 2023年4月. 大前博司, 森垣龍馬, 三宅一央, 松田拓, 中野渡友香, 久野恵, 松浦哲也, 髙木康志 :
高齢パーキンソン病患者に対する視床下核脳深部刺激療法による変化の検討,
第36回日本老年脳神経外科学会, 2023年4月. 森垣龍馬, 三宅一央, 松田拓, 小山広士, 宮本亮介, 和泉唯信, 中瀧理仁, 梶龍兒, 後藤惠, 髙木康志 :
機能性要素を合併したジストニア症例への手術加療をどう考えるか,
第62回日本定位・機能神経外科学会, 2023年1月. 森垣龍馬, 三宅一央, 小山広士, 松田拓, 髙木康志 :
STN-DBS術後にpainful abdominal contractionとbelly dancer's dyskinesiaを呈したパーキンソン病患者の一例,
第62回日本定位・機能神経外科学会, 2023年1月. 三宅一央, 森垣龍馬, 松田拓, 髙木康志 :
GPi-DBSのinterleaving刺激により，パーキンソン病でのすくみ足に効果を認めた一例,
日本脳神経外科学会第81回学術総会, 2022年9月. 森垣龍馬, 三宅一央, 松田拓, 宮本亮介, 和泉唯信, 中瀧理仁, 髙木康志 :
機能性要素を合併したジストニアへの手術加療,
日本脳神経外科学会第81回学術総会, 2022年9月. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性,
第51回日本脳卒中の外科学会学術集会, 2022年3月. 三宅一央, 森垣龍馬, 牟礼英生, 松田拓, 後藤惠, 髙木康志 :
Vo-DBS施行後から9年経過したDYT6ジストニア患者の長期予後,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
日本定位・機能神経外科学会機関紙, 2022年1月. 森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 :
特発性ジストニア患者の頭蓋骨の歪み,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
第61回日本定位・機能神経外科学会, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 髙木康志 :
全身性ジストニアの重症度と強迫観念の関係性についての検討,
日本脳神経外科学会学術総会, 2021年10月. 三宅一央, 森垣龍馬, 牟礼英生, 髙木康志 :
DYT6ジストニア患者におけるDBS術後9年の長期予後,
日本脳神経外科学会学術総会, 2021年10月. 森垣龍馬, 藤川丈自, 小田輝王, 中西浩, 山本伸昭, 三宅一央, 松田拓, 髙木康志 :
機械学習を用いた脳線条体免疫染色画像の解析,
日本脳神経外科学会学術総会, 2021年10月. 島田健司, 三宅一央, 山口泉, 宮本健志, 曽我部周, 兼松康久, 髙木康志 :
AVM摘出術における3D multimodal fusion imageとICG動注による術中videoangiography併用の有用性,
NMC Case Report Journal, 2021年10月. 森垣龍馬, 四方英二, 三宅一央, 松田拓, 髙木康志 :
神経刺激装置埋め込み術後の皮下血腫に対し漢方薬が奏功した3例,
第29回日本脳神経外科漢方医学会学術集会, 2021年10月. 森垣龍馬, 牟礼英生, 松田拓, 三宅一央, 宮本亮介, 藤田浩司, 中瀧理仁, 梶龍兒, 髙木康志, 後藤惠 :
機能ー器質ボーダーラインジストニアに対する脳深部刺激療法,
第60回日本定位・機能神経外科学会, 2021年1月. 牟礼英生, 森垣龍馬, 小山広士, 三宅一央, 松田拓, 宮本亮介, 藤田浩司, 和泉唯信, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討ー適応・長期成績・刺激条件についてー,
第60回日本定位・機能神経外科学会, 2021年1月. 三宅一央, 松田拓, 森垣龍馬, 牟礼英生, 髙木康志, 宮本亮介 :
ジストニックストームを生じたGNAO1遺伝子変異に対し淡蒼球脳深部刺激療法を行った1例,
第60回日本定位・機能神経外科学会, 2021年1月. 松田拓, 松元友暉, 森垣龍馬, 牟礼英生, 三宅一央, 加藤真介, 尾藤良孝, 原田雅史, 髙木康志 :
Quantitative parameter mappingを用いた3TMRIでの視床下核の可視化,
第60回日本定位・機能神経外科学会, 2021年1月. 三宅一央, 溝渕佳史, 永廣信治 :
左片麻痺症状にて発症した片頭痛発作の1例,
第37回徳島脳神経外科談話会, 2012年3月. 三宅一央, 影治照喜, 溝渕佳史, 倉敷佳孝, 永廣信治 :
転移性下垂体腫瘍の1例,
第35回徳島脳神経外科談話会, 2011年3月.

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補助金・競争的資金: ふたつの異なるモデルによるジストニア発症機序と治療ターゲットの解明 (研究課題/領域番号: 23K08523 )
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