トップ›研究者一覧›森垣龍馬

研究者を探す

研究者にアプローチする
更新情報を通知する

森垣龍馬

徳島大学

プロフィール
教育活動
研究活動
社会活動
リサーチマップ・
Jグローバル
KAKEN
注目研究

研究者総覧で最新データを確認する

2024年11月15日更新

職名: 特任教授
電話: 研究者総覧に該当データはありませんでした。
電子メール: morigaki.riyoma.1@tokushima-u.ac.jp
学歴: 研究者総覧に該当データはありませんでした。
学位: 医学博士 (徳島大学) (2017年)
職歴・経歴: 2013/4: 徳島大学特任助教, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学特任助教, 病院 (-2015.9.)
2015/10: 徳島大学助教, 大学院医歯薬学研究部 (-2018.9.)
2018/10: 徳島大学助教, 病院 (-2020.5.)
2020/6: 徳島大学特任准教授, 大学院医歯薬学研究部 (-2024.5.)
2024/6: 徳島大学特任教授, 大学院医歯薬学研究部

専門分野・研究分野: 脳神経外科 (Neurosurgery)

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 脳神経外科 (Neurosurgery)
担当経験のある授業科目: 健康医療と最新技術の社会への活用 (共通教育)
神経・精神・行動コース (学部)
指導経験: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 脳神経外科 (Neurosurgery)

研究テーマ: 機能的脳神経外科

著書

瓦井俊孝, 森垣龍馬, 沖良祐, 後藤惠, 梶龍兒 :
ALSとTFG,
科学評論社, 2015年4月.

(キーワード): TRK-fused gene (TFG) / amyotrophic lateral sclerosis / hereditary sensory motor neuropathy with proximal dominant involvement / vesicular transport / TDP-43

Ryoma Morigaki and Satoshi Goto :
Deep brain stimulation for essential tremor,
Springer, Switzerland, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-3-319-08476-3_11
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/978-3-319-08476-3_11

(DOI: 10.1007/978-3-319-08476-3_11) 森垣龍馬, 梶龍兒 :
Movement Disordersの内科的治療,
2013年12月. 梶龍兒, 浅沼光太郎, 瓦井俊孝, 宮﨑由道, 森垣龍馬, 後藤惠, 目崎高広, 太田悦朗, 小幡文弥, 豊島至, 藤本健一, 野村哲志, 中島健二, 坂本崇, 佐藤健太, 平孝臣, 横地房子, 小林一太, 片山容一, 小林武夫, 石毛美代子, 松本英之, 宇川義一, 玉川聡, 辻貞俊, 堀内正浩, 長谷川一子 :
ジストニアのすべて―最新の治療指針,
株式会社診断と治療社, 東京, 2013年5月. 森垣龍馬 :
重症度評価ーBurke-Fhan-Marsden ジストニア評価スケール,
2013年5月. Ryoma Morigaki, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto :
Thalamic deep brain stimulation for Parkinsons disease.,
2011. Ryoma Morigaki, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Current use of thalamic surgeries or treating movement disorders,
2011.

論文

Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia and Parkinson's disease.,
Scientific Reports, Vol.13, No.1, 2023.

(要約): Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms.
(キーワード): Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus
(徳島大学機関リポジトリ): ● Metadata: 118394
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-023-37833-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081; ● Search Scopus @ Elsevier (PMID): 37420081; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3

(徳島大学機関リポジトリ: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081) Nobuaki Yamamoto, Kazutaka Kuroda, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Ryoma Morigaki, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi :
Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot,
Internal Medicine, Vol.62, No.6, 909-913, 2023.

(要約): Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion.
(キーワード): mechanical thrombectomy / long-sheath introducer / giant clot / cerebral large-vessel occlusion
(徳島大学機関リポジトリ): ● Metadata: 118794
(出版サイトへのリンク): ● Publication site (DOI): 10.2169/internalmedicine.0089-22
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35945008; ● CiNii @ 国立情報学研究所 (CRID): 1390576900004177024; ● Search Scopus @ Elsevier (PMID): 35945008; ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0089-22

(徳島大学機関リポジトリ: 118794, DOI: 10.2169/internalmedicine.0089-22, PubMed: 35945008, CiNii: 1390576900004177024) Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki, Masafumi Harada and Yasushi Takagi :
Obsessivecompulsive symptoms are negatively correlated with motor severity in patients with generalized dystonia,
Scientific Reports, Vol.12, No.1, 20350, 2022.

(要約): We aimed to clarify the correlations between motor symptoms and obsessive-compulsive symptoms and between the volumes of basal ganglia components and obsessive-compulsive symptoms. We retrospectively included 14 patients with medically intractable, moderate and severe generalized dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale and Maudsley Obsessional Compulsive Inventory were used to evaluate the severity of dystonia and obsessive-compulsive symptoms, respectively. Patients with generalized dystonia were divided into two groups; patients whose Maudsley Obsessional Compulsive Inventory score was lower than 13 (Group 1) and 13 or more (Group 2). Additionally, the total Maudsley Obsessional Compulsive Inventory scores in patients with dystonia were significantly higher than normal volunteers' scores (p = 0.025). Unexpectedly, Group 2 (high Maudsley Obsessional Compulsive Inventory scores) showed milder motor symptoms than Group 1 (low Maudsley Obsessional Compulsive Inventory scores) (p = 0.016). "Checking" rituals had a strong and significant negative correlation with the Burke-Fahn-Marsden Dystonia Rating Scale (ϱ = - 0.71, p = 0.024) and a strong positive correlation with the volumes of both sides of the nucleus accumbens (right: ϱ = 0.72, p = 0.023; left: ϱ = 0.70, p = 0.034). Our results may provide insights into the pathogenesis of obsessive-compulsive disorder and dystonia.
(キーワード): Humans / Dystonia / Retrospective Studies / Dystonic Disorders / Heredodegenerative Disorders, Nervous System
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/s41598-022-24826-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36437372; ● Search Scopus @ Elsevier (PMID): 36437372; ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-24826-x

(DOI: 10.1038/s41598-022-24826-x, PubMed: 36437372) J Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, H Nakanishi, T Oda, Yuishin Izumi and Yasushi Takagi :
Diagnosis and Treatment of Tremor in Parkinson's Disease Using Mechanical Devices,
Life, Vol.13, No.1, 78, 2022.

(要約): Parkinsonian tremors are sometimes confused with essential tremors or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices are also commonly used to treat tremors and have been actively researched and developed. Here, we aimed to review recent progress and the efficacy of the devices related to Parkinsonian tremors. The PubMed and Scopus databases were searched for articles. We searched for "Parkinson disease" and "tremor" and "device". Eighty-six articles were selected by our systematic approach. Many studies demonstrated that the diagnosis and evaluation of tremors in patients with PD can be done accurately by machine learning algorithms. Mechanical devices for tremor suppression include deep brain stimulation (DBS), electrical muscle stimulation, and orthosis. In recent years, adaptive DBS and optimization of stimulation parameters have been studied to further improve treatment efficacy. Due to developments using state-of-the-art techniques, effectiveness in diagnosing and evaluating tremor and suppressing it using these devices is satisfactorily high in many studies. However, other than DBS, no devices are in practical use. To acquire high-level evidence, large-scale studies and randomized controlled trials are needed for these devices.
(徳島大学機関リポジトリ): ● Metadata: 118913
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life13010078
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36676025; ● Search Scopus @ Elsevier (PMID): 36676025; ● Search Scopus @ Elsevier (DOI): 10.3390/life13010078

(徳島大学機関リポジトリ: 118913, DOI: 10.3390/life13010078, PubMed: 36676025) Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi and Yasushi Takagi :
Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.,
Frontiers in Aging Neuroscience, Vol.14, 2022.

(要約): Invasive and non-invasive medical devices have unique characteristics, and several RCTs have been conducted for each device. Invasive devices are more effective, while non-invasive devices are less effective and have lower hurdles and risks. It is important to understand the characteristics of each device and capitalize on these.
(徳島大学機関リポジトリ): ● Metadata: 117340
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fnagi.2022.807909
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35462692; ● Search Scopus @ Elsevier (PMID): 35462692; ● Search Scopus @ Elsevier (DOI): 10.3389/fnagi.2022.807909

(徳島大学機関リポジトリ: 117340, DOI: 10.3389/fnagi.2022.807909, PubMed: 35462692) Ryoma Morigaki, Ryosuke Miyamoto, Taku Matsuda, Kazuhisa Miyake, Nobuaki Yamamoto and Yasushi Takagi :
Dystonia and cerebellum: From bench to bedside,
Life, Vol.11, No.8, 776, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116560
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11080776
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3390/life11080776

(徳島大学機関リポジトリ: 116560, DOI: 10.3390/life11080776) Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki, Yuishin Izumi and Yasushi Takagi :
Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter,
Journal of Neuroendovascular Therapy, Vol.16, No.5, 277-282, 2021.

(要約): Objective: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.Case Presentations: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.Conclusion: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.
(キーワード): percutaneous transluminal angioplasty / aspiration catheter
(出版サイトへのリンク): ● Publication site (DOI): 10.5797/jnet.cr.2021-0030
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390573593425698304; ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2021-0030

(DOI: 10.5797/jnet.cr.2021-0030, CiNii: 1390573593425698304) Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi :
Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia,
Life, Vol.11, No.6, 477, 2021.

(要約): Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.
(徳島大学機関リポジトリ): ● Metadata: 116561
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life11060477
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34074009; ● Summary page in Scopus @ Elsevier: 2-s2.0-85107554331

(徳島大学機関リポジトリ: 116561, DOI: 10.3390/life11060477, PubMed: 34074009, Elsevier: Scopus) Daisy Ma Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, P Rollin Tabuena and Toshitaka Kawarai :
Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 400-403, 2021.

(要約): Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021.
(キーワード): Ataxia / Humans / Philippines / Siblings / Vitamin E Deficiency
(徳島大学機関リポジトリ): ● Metadata: 116574
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759169; ● Search Scopus @ Elsevier (PMID): 34759169; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.400

(徳島大学機関リポジトリ: 116574, DOI: 10.2152/jmi.68.400, PubMed: 34759169) Nobuaki Yamamoto, Yuishin Izumi, Yuki Yamamoto, K Kuroda, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki and Yasushi Takagi :
Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion,
Clinical Neurology and Neurosurgery, Vol.199, 106316, 2020.

(要約): The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission.
(キーワード): Aged / Aged, 80 and over / Brain Ischemia / Cerebrovascular Disorders / Diffusion Magnetic Resonance Imaging / Female / Humans / Ischemic Stroke / Male / Middle Aged / Patient Admission / Prospective Studies / Retrospective Studies / Severity of Illness Index
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2020.106316
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33161217; ● Search Scopus @ Elsevier (PMID): 33161217; ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2020.106316

(DOI: 10.1016/j.clineuro.2020.106316, PubMed: 33161217) Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto :
Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components.,
Brain Sciences, Vol.10, No.9, 636, 2020.

(要約): The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery.
(徳島大学機関リポジトリ): ● Metadata: 116502
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci10090636
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724; ● Search Scopus @ Elsevier (PMID): 32942724; ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636

(徳島大学機関リポジトリ: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724) Hideo Mure, Naoto Toyoda, Ryoma Morigaki, Koji Fujita and Yasushi Takagi :
Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature.,
Stereotactic and Functional Neurosurgery, Vol.98, No.6, 399-403, 2020.

(要約): Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS.
(キーワード): Aged / Deep Brain Stimulation / Female / Globus Pallidus / Humans / Hypoxia-Ischemia, Brain / Intraoperative Neurophysiological Monitoring / Microelectrodes / Myoclonus / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000509318
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32894852; ● Search Scopus @ Elsevier (PMID): 32894852; ● Search Scopus @ Elsevier (DOI): 10.1159/000509318

(DOI: 10.1159/000509318, PubMed: 32894852) Makoto Kinoshita, Masahito Nakataki, Ryoma Morigaki, Satsuki Sumitani, Satoshi Goto, Ryuji Kaji and Tetsuro Ohmori :
Turning on the Left Side Electrode Changed Depressive State to Manic State in a Parkinson's Disease Patient Who Received Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Case Report.,
Clinical Psychopharmacology and Neuroscience, Vol.16, No.4, 494-496, 2018.

(要約): No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.
(徳島大学機関リポジトリ): ● Metadata: 114301
(出版サイトへのリンク): ● Publication site (DOI): 10.9758/cpn.2018.16.4.494
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30466222; ● Summary page in Scopus @ Elsevier: 2-s2.0-85055838752

(徳島大学機関リポジトリ: 114301, DOI: 10.9758/cpn.2018.16.4.494, PubMed: 30466222, Elsevier: Scopus) Toshitaka Kawarai, Ryosuke Miyamoto, Eiji Nakagawa, Reiko Koichihara, Takashi Sakamoto, Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Ryosuke Oki, Celeste Montecchiani, Carlo Caltagirone, Antonio Orlacchio, Ayako Hattori, Hideaki Mashimo, Yuishin Izumi, Takahiro Mezaki, Satoko Kumada, Makoto Taniguchi, Fusako Yokochi, Shinji Saitoh, Satoshi Goto and Ryuji Kaji :
Phenotype variability and allelic heterogeneity in KMT2B-Associated disease.,
Parkinsonism & Related Disorders, 2018.

(要約): We further demonstrate the allelic heterogeneity and phenotypic variations of KMT2B-associated disease. Haploinsufficiency is one of molecular pathomechanisms underlying the disease. Cardinal clinical features include combined dystonia accompanying mild psychomotor disability. Cerebellum would be affected in KMT2B-associated disease.
(キーワード): Dystonia
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.parkreldis.2018.03.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29653907; ● Search Scopus @ Elsevier (PMID): 29653907; ● Search Scopus @ Elsevier (DOI): 10.1016/j.parkreldis.2018.03.022

(DOI: 10.1016/j.parkreldis.2018.03.022, PubMed: 29653907) 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 岡久哲也, 加藤真介, 梶龍兒, 髙木康志, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携,
機能的脳神経外科, Vol.57, 35-39, 2018年.

(キーワード): ジストニア / 脳深部刺激療法 / 多職種連携 / Dystonia / DBS / Multidisciplinary / Collaboration
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520572358412476800

(CiNii: 1520572358412476800) Toshitaka Kawarai, Ryoma Morigaki, Ryuji Kaji and Satoshi Goto :
Clinicopathological Phenotype and Genetics of X-Linked Dystonia-Parkinsonism (XDP; DYT3; Lubag).,
Brain Sciences, Vol.7, No.7, 72, 2017.

(要約): X-linked dystonia-parkinsonism (XDP; OMIM314250), also referred to as DYT3 dystonia or "Lubag" disease, was first described as an endemic disease in the Philippine island of Panay. XDP is an adult-onset movement disorder characterized by progressive and severe dystonia followed by overt parkinsonism in the later years of life. Among the primary monogenic dystonias, XDP has been identified as a transcriptional dysregulation syndrome with impaired expression of the TAF1 (TATA box-binding protein associated factor 1) gene, which is a critical component of the cellular transcription machinery. The major neuropathology of XDP is progressive neuronal loss in the neostriatum (i.e., the caudate nucleus and putamen). XDP may be used as a human disease model to elucidate the pathomechanisms by which striatal neurodegeneration leads to dystonia symptoms. In this article, we introduce recent advances in the understanding of the interplay between pathophysiology and genetics in XDP.
(徳島大学機関リポジトリ): ● Metadata: 114300
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci7070072
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28672841; ● Summary page in Scopus @ Elsevier: 2-s2.0-85021763034

(徳島大学機関リポジトリ: 114300, DOI: 10.3390/brainsci7070072, PubMed: 28672841, Elsevier: Scopus) Ryoma Morigaki and Satoshi Goto :
Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.,
Brain Sciences, Vol.7, No.6, 2017.

(要約): Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. In HD, striking neuropathological changes occur in the striatum, including loss of medium spiny neurons and parvalbumin-expressing interneurons accompanied by neurodegeneration of the striosome and matrix compartments, leading to progressive impairment of reasoning, walking and speaking abilities. The precise cause of striatal pathology in HD is still unknown; however, accumulating clinical and experimental evidence suggests multiple plausible pathophysiological mechanisms underlying striatal neurodegeneration in HD. Here, we review and discuss the characteristic neurodegenerative patterns observed in the striatum of HD patients and consider the role of various huntingtin-related and striatum-enriched proteins in neurotoxicity and neuroprotection.
(徳島大学機関リポジトリ): ● Metadata: 114299
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/brainsci7060063
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28590448; ● Search Scopus @ Elsevier (PMID): 28590448; ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci7060063

(徳島大学機関リポジトリ: 114299, DOI: 10.3390/brainsci7060063, PubMed: 28590448) 牟礼英生, 森垣龍馬, 大北真哉, 宮本亮介, 梶龍兒, 永廣信治, 後藤惠 :
ジストニアに対する脳深部刺激療法:淡蒼球刺激と視床刺激の併用,
機能的脳神経外科, Vol.55, 80-86, 2016年.

(キーワード): ジストニア / 脳深部刺激療法 / 淡蒼球内接 / 視床吻腹側核 / Dystonia / DBS / GPi / Thalamic Vo nucleus
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853833839457024

(CiNii: 1520853833839457024) Ryoma Morigaki, Hideo Mure, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto :
Therapeutic Perspective on Tardive Syndrome with Special Reference to Deep Brain Stimulation,
Frontiers in Psychiatry, Vol.7, 207, 2016.

(要約): Tardive syndrome (TDS) is a potentially permanent and irreversible hyperkinetic movement disorder caused by exposure to dopamine receptor blocking agents. Guidelines published by the American Academy of Neurology recommend pharmacological first-line treatment for TDS with clonazepam (level B), ginkgo biloba (level B), amantadine (level C), and tetrabenazine (level C). Recently, a class II study provided level C evidence for use of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with TDS. Although the precise pathogenesis of TDS remains to be elucidated, the beneficial effects of GPi-DBS in patients with TDS suggest that the disease may be a basal ganglia disorder. In addition to recent advances in understanding the pathophysiology of TDS, this article introduces the current use of DBS in the treatment of medically intractable TDS.
(徳島大学機関リポジトリ): ● Metadata: 114470
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fpsyt.2016.00207
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28082923; ● Summary page in Scopus @ Elsevier: 2-s2.0-85009160109

(徳島大学機関リポジトリ: 114470, DOI: 10.3389/fpsyt.2016.00207, PubMed: 28082923, Elsevier: Scopus) Ryoma Morigaki and Satoshi Goto :
Putaminal Mosaic Visualized by Tyrosine Hydroxylase Immunohistochemistry in the Human Neostriatum.,
Frontiers in Neuroanatomy, Vol.10, 2016.

(要約): Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the "motor" circuits that control voluntary movements and motor learning. The human neostriatum comprises two functional subdivisions known as the striosome (patch) and matrix compartments. Accumulating evidence suggests that compartment-specific dysregulations of dopamine activity might be involved in the disease-specific pathology and symptoms of human striatal diseases including movement disorders. This study was undertaken to examine whether or how striatal dopaminergic innervations are organized into the compartmentalized architecture found in the putamen of adult human brains. For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains. Herein, we report that discrete compartmentalization of TH-labeled innervations occurs in the putamen, as in the caudate nucleus (CN), with a higher density of TH labeling in the matrix compared to the striosomes. Our results provide anatomical evidence to support the hypothesis that compartment-specific dysfunction of the striosome-matrix dopaminergic systems might contribute to the genesis of movement disorders.
(徳島大学機関リポジトリ): ● Metadata: 114298
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fnana.2016.00034
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27092059; ● Search Scopus @ Elsevier (PMID): 27092059; ● Search Scopus @ Elsevier (DOI): 10.3389/fnana.2016.00034

(徳島大学機関リポジトリ: 114298, DOI: 10.3389/fnana.2016.00034, PubMed: 27092059) 大北真哉, 牟礼英生, 森垣龍馬, 永廣信治, 後藤惠 :
小児の全身性ジストニアに対し脳深部刺激術を施行した1例,
小児の脳神経, Vol.41, No.1, 86, 2016年. Ryoma Morigaki, Ryosuke Miyamoto, Shinya Ohkita, Yoshifumi Mizobuchi, Hideo Mure, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Nuclear factor kappa b is under the control of dopamine signaling in the mouse striatum,
Neurologia Medico-Chirurgica, Vol.55, 305, 2016. Ryoma Morigaki and Satoshi Goto :
Postsynaptic Density Protein 95 in the Striosome and Matrix Compartments of the Human Neostriatum.,
Frontiers in Neuroanatomy, Vol.9, 154, 2015.

(要約): The human neostriatum consists of two functional subdivisions referred to as the striosome (patch) and matrix compartments. The striosome-matrix dopamine systems play a central role in cortico-thalamo-basal ganglia circuits, and their involvement is thought to underlie the genesis of multiple movement and behavioral disorders, and of drug addiction. Human neuropathology also has shown that striosomes and matrix have differential vulnerability patterns in several striatal neurodegenerative diseases. Postsynaptic density protein 95 (PSD-95), also known as disks large homolog 4, is a major scaffolding protein in the postsynaptic densities of dendritic spines. PSD-95 is now known to negatively regulate not only N-methyl-D-aspartate glutamate signaling, but also dopamine D1 signals at sites of postsynaptic transmission. Accordingly, a neuroprotective role for PSD-95 against dopamine D1 receptor (D1R)-mediated neurotoxicity in striatal neurodegeneration also has been suggested. Here, we used a highly sensitive immunohistochemistry technique to show that in the human neostriatum, PSD-95 is differentially concentrated in the striosome and matrix compartments, with a higher density of PSD-95 labeling in the matrix compartment than in the striosomes. This compartment-specific distribution of PSD-95 was strikingly complementary to that of D1R. In addition to the possible involvement of PSD-95-mediated synaptic function in compartment-specific dopamine signals, we suggest that the striosomes might be more susceptible to D1R-mediated neurotoxicity than the matrix compartment. This notion may provide new insight into the compartment-specific vulnerability of MSNs in striatal neurodegeneration.
(徳島大学機関リポジトリ): ● Metadata: 114468
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fnana.2015.00154
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26648848; ● Search Scopus @ Elsevier (PMID): 26648848; ● Search Scopus @ Elsevier (DOI): 10.3389/fnana.2015.00154

(徳島大学機関リポジトリ: 114468, DOI: 10.3389/fnana.2015.00154, PubMed: 26648848) Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Mitsuru Sanada, Koji Fujita, Toshitaka Kawarai, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Shigeo Murayama, Yuishin Izumi and Ryuji Kaji :
Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar atrophy.,
Neurology, Vol.85, No.17, 1522-1524, 2015.

(キーワード): Asphyxia / Atrophy / Autopsy / 脳 (brain) / Cerebellar Ataxia / 小脳 (cerebellum) / Dysphonia / Dystonic Disorders / Humans / 男性 (male) / Middle Aged / Prone Position
(出版サイトへのリンク): ● Publication site (DOI): 10.1212/WNL.0000000000002061
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26408497; ● Search Scopus @ Elsevier (PMID): 26408497; ● Search Scopus @ Elsevier (DOI): 10.1212/WNL.0000000000002061

(DOI: 10.1212/WNL.0000000000002061, PubMed: 26408497) Satoshi Goto, Ryoma Morigaki, Shinya Okita, Shinji Nagahiro and Ryuji Kaji :
Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains.,
Frontiers in Neuroanatomy, Vol.9, No.22, 2015.

(要約): Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Our IHC method, which we call the PBTA method, involves a hybrid protocol that implements aspects of both the polymer and avidin-biotin-complex (ABC) methods in combination with biotin-tyramide amplification. When using [Met]-enkephalin as a target antigen, the sensitivity of the PBTA method for IHC was more than 100-fold higher compared with the polymer and ABC methods. In addition, its sensitivity for enzyme-linked immunosorbent assay was about 1,000-fold higher compared with the ABC method. We examined the utility of our IHC method for both chromogenic and fluorescence detection systems used to visualize neurochemical peptides and proteins in formalin-fixed, paraffin-embedded tissues from autopsied human brains. The results convincingly demonstrate that under optimal conditions, our IHC method is highly sensitive without increasing non-specific background activities. Our IHC method could be a powerful tool for detection and visualization of neurochemical antigens that are present even in trace amounts in autopsied human brains.
(徳島大学機関リポジトリ): ● Metadata: 114466
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fnana.2015.00022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25784860; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925154247

(徳島大学機関リポジトリ: 114466, DOI: 10.3389/fnana.2015.00022, PubMed: 25784860, Elsevier: Scopus) Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Shinya Okita, Toshitaka Kawarai, Ryosuke Miyamoto, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto :
Deep brain stimulation of the thalamic ventral lateral anterior nucleus for DYT6 dystonia.,
Stereotactic and Functional Neurosurgery, Vol.92, No.6, 393-396, 2014.

(要約): The thalamic VLa nucleus could serve as an alternative target in DBS therapy for DYT6 dystonia.
(キーワード): dystonia / deep brain stimulation / DYT6 / mutation / hereditary dystonia
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000365577
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25359437; ● Summary page in Scopus @ Elsevier: 2-s2.0-84910089742

(DOI: 10.1159/000365577, PubMed: 25359437, Elsevier: Scopus) Hidetaka Koizumi, Satoshi Goto, Shinya Okita, Ryoma Morigaki, Norio Akaike, Yasushi Torii, Tetsuhiro Harakawa, Akihiro Ginnaga and Ryuji Kaji :
Spinal Central Effects of Peripherally Applied Botulinum Neurotoxin A in Comparison between Its Subtypes A1 and A2.,
Frontiers in Neurology, Vol.5, No.98, 2014.

(要約): Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum neurotoxin A (BoNT/A) is used to treat a wide variety of disorders involving peripheral nerve terminal hyperexcitability. However, it has been a matter of debate whether this toxin has central or peripheral sites of action. We employed a rat model in which BoNT/A1 or BoNT/A2 was unilaterally injected into the gastrocnemius muscle. On time-course measurements of compound muscle action potential (CMAP) amplitudes after injection of BoNT/A1 or BoNT/A2 at doses ranging from 1.7 to 13.6 U, CMAP amplitude for the ipsilateral hind leg was markedly decreased on the first day, and this muscle flaccidity persisted up to the 14th day. Of note, both BoNT/A1 and BoNT/A2 administrations also resulted in decreased CMAP amplitudes for the contralateral leg in a dose-dependent manner ranging from 1.7 to 13.6 U, and this muscle flaccidity increased until the fourth day and then slowly recovered. Immunohistochemical results revealed that BoNT/A-cleaved synaptosomal-associated protein of 25 kDa (SNAP-25) appeared in the bilateral ventral and dorsal horns 4 days after injection of BoNT/A1 (10 U) or BoNT/A2 (10 U), although there seemed to be a wider spread of BoNT/A-cleaved SNAP-25 associated with BoNT/A1 than BoNT/A2 in the contralateral spinal cord. This suggests that the catalytically active BoNT/A1 and BoNT/A2 were axonally transported via peripheral motor and sensory nerves to the spinal cord, where they spread through a transcytosis (cell-to-cell trafficking) mechanism. Our results provide evidence for the central effects of intramuscularly administered BoNT/A1 and BoNT/A2 in the spinal cord, and a new insight into the clinical effects of peripheral BoNT/A applications.
(徳島大学機関リポジトリ): ● Metadata: 114463
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fneur.2014.00098
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25002857; ● Search Scopus @ Elsevier (PMID): 25002857; ● Search Scopus @ Elsevier (DOI): 10.3389/fneur.2014.00098

(徳島大学機関リポジトリ: 114463, DOI: 10.3389/fneur.2014.00098, PubMed: 25002857) Akie Tanabe, Yukio Yamamura, Jiro Kasahara, Ryoma Morigaki, Ryuji Kaji and Satoshi Goto :
A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease.,
Frontiers in Cellular Neuroscience, Vol.8, No.50, 2014.

(要約): Abnormal motor behaviors in Parkinson's disease (PD) result from striatal dysfunction due to an imbalance between dopamine and glutamate transmissions that are integrated by dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). c-Abelson tyrosine kinase (c-Abl) phosphorylates cyclin-dependent kinase 5 (Cdk5) at Tyr15 to increase the activity of Cdk5, which reduces the efficacy of dopaminergic signaling by phosphorylating DARPP-32 at Thr75 in the striatum. Here, we report that in the mouse striatum, a novel c-Abl inhibitor, nilotinib (AMN107), inhibits phosphorylation of both Cdk5 at Tyr15 and DARPP-32 at Thr75, which is negatively regulated by dopamine receptor activation through a D2 receptor-mediated mechanism. Like a D2-agonist, nilotinib synergizes with a D1-agonist for inducing striatal c-Fos expression. Moreover, systemic administration of nilotinib normalizes striatal motor behaviors in a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These findings suggest that nilotinib could possibly serve as a new and alternative agent for treating PD motor symptoms.
(徳島大学機関リポジトリ): ● Metadata: 114464
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fncel.2014.00050
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24600352; ● Summary page in Scopus @ Elsevier: 2-s2.0-84894260952

(徳島大学機関リポジトリ: 114464, DOI: 10.3389/fncel.2014.00050, PubMed: 24600352, Elsevier: Scopus) Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji :
Reversibility of ischemic findings on 3-tesla magnetic resonance T2(*)-weighted image after recanalization,
The Journal of Medical Investigation : JMI, Vol.61, No.1,2, 190-196, 2014.

(要約): Ischemic vessel signs (IVS) can be detected on 3-tesla T2(*)-weighted magnetic resonance images as a vessel enlargement at the territory of acute ischemia caused by major vessel occlusion or stenosis. Here, we studied changes in IVS before and after recanalization by the administration of intravenous recombinant tissue plasminogen activator (IV rtPA), carotid artery stenting or percutaneous transluminal angioplasty in patients with major vessel occlusion or stenosis. We performed magnetic resonance imaging for all patients treated by IV rtPA at the time of admission, shortly after and 24-72 hours after treatment with IV rtPA. We reviewed the IVS to assess its natural course of IVS by assessing patients who did not recanalize. IVS tended to disappear after recanalization. Conversely, in patients without recanalization, IVS did not disappear shortly after IV rtPA; rather, it disappeared 24-72 hours after IV rtPA, especially in the presence of complete infarction. Recanalization by IV rtPA or endovascular treatment contributed to improved clinical deficits or the prevention from further progression. IVS can be a parameter of misery perfusion and an important factor to detect the patients who have an indication of treatment for recanalization.
(キーワード): Administration, Intravenous / Aged / Aged, 80 and over / Angioplasty / Carotid Arteries / Carotid Stenosis / Diffusion Magnetic Resonance Imaging / Disease Progression / Female / Humans / 虚血 (ischemia) / Male / Middle Aged / Retrospective Studies / Stents / Time Factors / Tissue Plasminogen Activator / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 109553
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705765; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897951917

(徳島大学機関リポジトリ: 109553, DOI: 10.2152/jmi.61.190, PubMed: 24705765, Elsevier: Scopus) Yuka Terasawa, Nobuaki Yamamoto, Ryoma Morigaki, Koji Fujita, Yuishin Izumi, Junichiro Satomi, Masafumi Harada, Shinji Nagahiro and Ryuji Kaji :
Brush sign on 3-T t2*-weighted MRI as a potential predictor of hemorrhagic transformation after tissue plasminogen activator therapy,
Stroke, Vol.45, No.1, 274-276, 2014.

(要約): The brush sign (BS) is the enlargement of medullary veins on 3-T T2*-weighted MRI seen in patients with ischemic stroke because of major cerebral artery occlusion. However, the clinical relevance of BS in patients with acute stroke remains unclear. We assessed the correlation between detecting BS with the development of hemorrhagic transformation after intravenous thrombolysis. We enrolled consecutive patients with M1 or M2 occlusion treated with intravenous tissue plasminogen activator. We classified the patients into 2 groups: the group positive for BS (P-BS) and the group negative for BS (N-BS). We investigated the differences in MRI findings and the clinical outcome between the 2 groups. The subjects consisted of 36 patients (19 men; mean age, 74.7 years). Twenty-one patients (58%) had M1 occlusion, and 15 (42%) had M2 occlusion. Twenty-five patients (69%) were classified into the P-BS group and 11 (31%) into the N-BS group. Recanalization was observed in 15 (60%) and 10 (90%) patients in the P-BS and N-BS groups, respectively (P=0.116). Hemorrhagic transformation on MRI was observed more frequently in the P-BS group than in the N-BS group (64% versus 18%; P=0.027). A good outcome (mRS, 0-1) at discharge was found in 24% of patients in the P-BS group and in 45% of patients in the N-BS group (P=0.152). A multivariate logistic regression analysis revealed that the presence of BS (odds ratio, 9.08; 95% confidence interval, 1.4-59.8; P=0.022) was independently associated with hemorrhagic transformation. BS may predict the development of hemorrhagic transformation in patients with acute stroke treated with intravenous tissue plasminogen activator.
(キーワード): Aged / Aged, 80 and over / Cerebral Hemorrhage / Disease Progression / Female / Fibrinolytic Agents / Humans / Image Processing, Computer-Assisted / Intracranial Embolism / Magnetic Resonance Imaging / Male / Middle Aged / Prognosis / Prospective Studies / Stroke / Thrombolytic Therapy / Tissue Plasminogen Activator / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1161/STROKEAHA.113.002640
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24172577; ● Summary page in Scopus @ Elsevier: 2-s2.0-85027928664

(DOI: 10.1161/STROKEAHA.113.002640, PubMed: 24172577, Elsevier: Scopus) 森垣龍馬, 瓦井俊孝, 大北真哉, 牟礼英生, 小泉英貴, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠 :
X-linked dystonia-parkinsonismのニューロペプチドYシステム,
機能的脳神経外科, Vol.53, 47-55, 2014年.

(キーワード): X連鎖ジストニアーパーキンソニズム / DYT3 / ニューロペプチドY / 線条体 / ストリオソーム
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520290884129170304

(CiNii: 1520290884129170304) Hidetaka Koizumi, Ryoma Morigaki, Shinya Ohkita, Shinji Nagahiro, Masanori Nakagawa and Satoshi Goto :
Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinsons disease: a potential compensatory role,
Frontiers in Cellular Neuroscience, Vol.7, 74, 2013.

(要約): The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification (TSA) protocols to determine the distributional patterns of opioid receptors in the striosome-matrix systems of the rat striatum. As a most striking feature of striatal opioid anatomy, MORs are highly enriched in the striosomes and subcallosal streak. We also found that DORs are localized in a mosaic pattern in the dorsal striatum (caudate-putamen), with heightened labeling for DOR in the striosomes relative to the matrix compartment. In the 6-hydroxydopamine-lesioned rat model of PD, lesions of the nigrostriatal pathways caused a significant reduction of striatal labeling for both the MOR and DOR in the striosomes, but not in the matrix compartment. Our results suggest that the activities of the striosome and matrix compartments are differentially regulated by the opioid signals involving the MORs and DORs, and that the striosomes may be more responsive to opioid peptides (e.g., enkephalin) than the matrix compartment. Based on a model in which the striosome compartment regulates the striatal activity, we propose a potent compensatory role of striosomal opioid signaling under the conditions of the striatal dopamine depletion that occurs in PD.
(徳島大学機関リポジトリ): ● Metadata: 114465
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fncel.2013.00074
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23730270; ● Summary page in Scopus @ Elsevier: 2-s2.0-84877285159

(徳島大学機関リポジトリ: 114465, DOI: 10.3389/fncel.2013.00074, PubMed: 23730270, Elsevier: Scopus) Satoshi Goto, Toshitaka Kawarai, Ryoma Morigaki, Shinya Okita, Hidetaka Koizumi, Shinji Nagahiro, L Edwin Munoz, V Lillian Lee and Ryuji Kaji :
Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism.,
Brain, Vol.136, No.Pt 5, 1555-1567, 2013.

(要約): Neuropeptide Y is a novel bioactive substance that plays a role in the modulation of neurogenesis and neurotransmitter release, and thereby exerts a protective influence against neurodegeneration. Using a sensitive immunohistochemical method with a tyramide signal amplification protocol, we performed a post-mortem analysis to determine the striatal localization profile of neuropeptide Y in neurologically normal individuals and in patients with X-linked dystonia-parkinsonism, a major representative of the neurodegenerative diseases that primarily involve the striatum. All of the patients examined were genetically verified as having X-linked dystonia-parkinsonism. In normal individuals, we found a scattered distribution of neuropeptide Y-positive neurons and numerous nerve fibres labelled for neuropeptide Y in the striatum. Of particular interest was a differential localization of neuropeptide Y immunoreactivity in the striatal compartments, with a heightened density of neuropeptide Y labelling in the matrix compartment relative to the striosomes. In patients with X-linked dystonia-parkinsonism, we found a significant decrease in the number of neuropeptide Y-positive cells accompanied by a marked loss of their nerve fibres in the caudate nucleus and putamen. The patients with X-linked dystonia-parkinsonism also showed a lack of neuropeptide Y labelling in the subventricular zone, where a marked loss of progenitor cells that express proliferating cell nuclear antigen was found. Our results indicate a neostriatal defect of the neuropeptide Y system in patients with X-linked dystonia-parkinsonism, suggesting its possible implication in the mechanism by which a progressive loss of striatal neurons occurs in X-linked dystonia-parkinsonism.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/brain/awt084
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23599389; ● Search Scopus @ Elsevier (PMID): 23599389; ● Search Scopus @ Elsevier (DOI): 10.1093/brain/awt084

(DOI: 10.1093/brain/awt084, PubMed: 23599389) Yukio Yamamura, Ryoma Morigaki, Jiro Kasahara, Hironori Yokoyama, Akie Tanabe, Shinya Ohkita, Hidetaka Koizumi, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice,
Frontiers in Cellular Neuroscience, Vol.7, No.12, 1-10, 2013.

(要約): Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in the striatum. c-Abelson tyrosine kinase (c-Abl) is known to phosphorylate Cdk5 at Tyr15 (Tyr15-Cdk5) and thereby facilitates the Cdk5 activity. We here report that Cdk5 with Tyr15 phosphorylation (Cdk5-pTyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of Tyr15-Cdk5 by acting through the D2 class dopamine receptors. Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. Our results suggest a functional link of Cdk5-pTyr15 with postsynaptic dopamine and glutamate signals through the c-Abl kinase activity in the striatum.
(徳島大学機関リポジトリ): ● Metadata: 114613
(出版サイトへのリンク): ● Publication site (DOI): 10.3389/fncel.2013.00012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23420105; ● Search Scopus @ Elsevier (PMID): 23420105; ● Search Scopus @ Elsevier (DOI): 10.3389/fncel.2013.00012

(徳島大学機関リポジトリ: 114613, DOI: 10.3389/fncel.2013.00012, PubMed: 23420105) Hiroyuki Ishiura, Wataru Sako, Mari Yoshida, Toshitaka Kawarai, Osamu Tanabe, Jun Goto, Yuji Takahashi, Hidetoshi Date, Jun Mitsui, Budrul Ahsan, Yaeko Ichikawa, Atsushi Iwata, Hiide Yoshino, Yuishin Izumi, Koji Fujita, Kouji Maeda, Satoshi Goto, Hidetaka Koizumi, Ryoma Morigaki, Masako Ikemura, Naoko Yamauchi, Shigeo Murayama, A Garth Nicholson, Hidefumi Ito, Gen Sobue, Masanori Nakagawa, Ryuji Kaji and Shoji Tsuji :
The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.,
American Journal of Human Genetics, Vol.91, No.2, 320-329, 2012.

(要約): Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. To date, large families affected by HMSN-P have been reported from two different regions in Japan. Linkage and haplotype analyses of two previously reported families and two new families with the use of high-density SNP arrays further defined the minimum candidate region of 3.3 Mb in chromosomal region 3q12. Exome sequencing showed an identical c.854C>T (p.Pro285Leu) mutation in the TRK-fused gene (TFG) in the four families. Detailed haplotype analysis suggested two independent origins of the mutation. Pathological studies of an autopsied patient revealed TFG- and ubiquitin-immunopositive cytoplasmic inclusions in the spinal and cortical motor neurons. Fragmentation of the Golgi apparatus, a frequent finding in amyotrophic lateral sclerosis, was also observed in the motor neurons with inclusion bodies. Moreover, TAR DNA-binding protein 43 kDa (TDP-43)-positive cytoplasmic inclusions were also demonstrated. In cultured cells expressing mutant TFG, cytoplasmic aggregation of TDP-43 was demonstrated. These findings indicate that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TDP-43 underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
(キーワード): Base Sequence / Chromosomes, Human, Pair 3 / DNA-Binding Proteins / Exome / Genetic Linkage / Genetic Predisposition to Disease / Golgi Apparatus / Haplotypes / Hereditary Sensory and Motor Neuropathy / Humans / Inclusion Bodies / 日本 (Japan) / Molecular Sequence Data / Motor Neurons / Pedigree / Point Mutation / Polymorphism, Single Nucleotide / Proteins / Sequence Analysis, DNA
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ajhg.2012.07.014
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22883144; ● Search Scopus @ Elsevier (PMID): 22883144; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajhg.2012.07.014

(DOI: 10.1016/j.ajhg.2012.07.014, PubMed: 22883144) Ryoma Morigaki, Kyong-Hon Pooh, Kenji Shouno, Hidekazu Taniguchi, Shouichi Endo and Yoshinobu Nakagawa :
Choroid plexus papilloma in a girl with hypomelanosis of Ito.,
Journal of Neurosurgery. Pediatrics, Vol.10, No.3, 182-185, 2012.

(要約): The authors report a case of choroid plexus papilloma in a girl with hypomelanosis of Ito, and they review the literature in brief. Hypomelanosis of Ito is a rare neurocutaneous syndrome characterized by cutaneous hypopigmented whorls, streaks, and patches along lines of Blaschko. Most patients exhibit CNS manifestations, including psychomotor retardation, seizures, hypotonia, and ataxia. A 6-year-old girl with hypomelanosis of Ito was referred to the authors' hospital with bilateral tumors in the lateral ventricles. The right lateral ventricle tumor was surgically removed. Immunohistochemical investigations revealed the tumor to be a choroid plexus papilloma (WHO Grade I). A chromosomal investigation revealed that the tumor tissue demonstrated a large loss of heterozygosity at chromosome 10. The case reported here serves as a reminder that de novo brain tumors may arise in patients with chromosomal mosaicism.
(キーワード): Child / Chromosomes, Human, Pair 10 / Female / Humans / Hypopigmentation / Immunohistochemistry / Intellectual Disability / Lateral Ventricles / Loss of Heterozygosity / Magnetic Resonance Imaging / Papilloma, Choroid Plexus
(徳島大学機関リポジトリ): ● Metadata: 114558
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2012.5.PEDS11556
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22793165; ● Search Scopus @ Elsevier (PMID): 22793165; ● Search Scopus @ Elsevier (DOI): 10.3171/2012.5.PEDS11556

(徳島大学機関リポジトリ: 114558, DOI: 10.3171/2012.5.PEDS11556, PubMed: 22793165) Ryosuke Miyamoto, Satoshi Goto, Wataru Sako, Ai Miyashiro, Isabelle Kim, Fabienne Escande, Masafumi Harada, Ryoma Morigaki, Koutaro Asanuma, Yoshifumi Mizobuchi, Shinji Nagahiro, Yuishin Izumi and Ryuji Kaji :
Generalized dystonia in a patient with a novel mutation in the GLUD1 gene,
Movement Disorders, Vol.27, No.9, 1198-1199, 2012.

(キーワード): Adolescent / Deep Brain Stimulation / Dystonic Disorders / Electroencephalography / Epilepsy, Tonic-Clonic / Female / Glutamate Dehydrogenase / Humans / Hyperinsulinism / Mutation / Polymerase Chain Reaction
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mds.25081
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22730017; ● Summary page in Scopus @ Elsevier: 2-s2.0-84864777670

(DOI: 10.1002/mds.25081, PubMed: 22730017, Elsevier: Scopus) Toshiyuki Okazaki, Teruyoshi Kageji, Kazuyuki Kuwamura, Keiko T. Kitazato, Hideo Mure, Keijiro Hara, Ryoma Morigaki, Yoshifumi Mizobuchi, Kazuhito Matsuzaki and Shinji Nagahiro :
Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma,
Cancer Letters, Vol.323, No.2, 199-207, 2012.

(要約): Interferon-beta (IFN-) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN--induced increase in endogenous PML contributes to anti-tumor effects in p53 wild- and mutant glioma cells in a xenograft mice model. The increased PML promoted the accumulation of p73, a structural and functional homolog of p53, to fuse the coactivator Yes-associated-protein in the PML nuclear bodies. The adjuvant therapy targeted at PML may be a promising therapeutic strategy for glioblastoma.
(キーワード): Apoptosis / Base Sequence / Blotting, Western / Brain Neoplasms / Cell Line, Tumor / DNA Primers / DNA-Binding Proteins / Dacarbazine / Glioblastoma / Humans / Interferon-beta / Nuclear Proteins / Real-Time Polymerase Chain Reaction / Transcription Factors / Tumor Suppressor Proteins / Up-Regulation
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.canlet.2012.04.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22542810; ● Search Scopus @ Elsevier (PMID): 22542810; ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2012.04.013

(DOI: 10.1016/j.canlet.2012.04.013, PubMed: 22542810) Ryoma Morigaki, Junichiro Satomi, E Shikata and Shinji Nagahiro :
Aneurysm of the lateral spinal artery: A case report,
Clinical Neurology and Neurosurgery, Vol.114, 713-716, 2012.

(キーワード): Aged / Arterial Occlusive Diseases / Arteries / Cerebral Angiography / Cervical Vertebrae / Embolization, Therapeutic / Endovascular Procedures / Headache / Humans / Magnetic Resonance Angiography / Magnetic Resonance Imaging / Male / Spinal Diseases / Subarachnoid Hemorrhage / Tomography, X-Ray Computed / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clineuro.2011.12.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22257516; ● Search Scopus @ Elsevier (PMID): 22257516; ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2011.12.003

(DOI: 10.1016/j.clineuro.2011.12.003, PubMed: 22257516) S Okita, Ryoma Morigaki, H Koizumi, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto :
Cell type-specific localization of optineurin in the striatal neurons of mice: Implications for neuronal vulnerability in huntington's disease,
Neuroscience, Vol.202, No.27, 363-370, 2012.

(要約): Striatal neuropathology of Huntington's disease (HD) involves primary and progressive degeneration of the medium-sized projection neurons, with relative sparing of the local circuit interneurons. The mechanism for such a patterned cell loss in the HD striatum continues to remain unclear. Optineurin (OPTN) is one of the proteins interacting with huntingtin and plays a protective role in several neurodegenerative disorders. To determine the cellular localization pattern of OPTN in the mouse striatum, we employed a highly sensitive immunohistochemistry with the tyramide signal amplification system. In this study, we show that OPTN appeared as a cytoplasmic protein within the subsets of the striatal neurons. Of particular interest was that OPTN was abundantly expressed in the interneurons, whereas low levels of OPTN were observed in the medium projection neurons. This cell type-specific distribution of OPTN in the striatum is strikingly complementary to the pattern of neuronal loss typically observed in the striatum of patients with HD. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in HD.
(キーワード): Animals / Blotting, Western / 細胞死 (cell death) / Corpus Striatum / Densitometry / Eye Proteins / Glutamic Acid / Huntington Disease / Image Processing, Computer-Assisted / 免疫組織化学 (immunohistochemistry) / Interneurons / Male / Mice / Mice, Inbred C57BL / Mice, Transgenic / Mutation / Neurons / Serotonin Plasma Membrane Transport Proteins
(徳島大学機関リポジトリ): ● Metadata: 116978
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.neuroscience.2011.11.059
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22155493; ● Search Scopus @ Elsevier (PMID): 22155493; ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuroscience.2011.11.059

(徳島大学機関リポジトリ: 116978, DOI: 10.1016/j.neuroscience.2011.11.059, PubMed: 22155493) 森垣龍馬, 瓦井俊孝, 中瀧理仁, 伊賀淳一, 佐光亘, 溝渕佳史, 永廣信治, 後藤惠, 梶龍兒 :
X-linked dystonia-parkinsonism患者の臨床症状の検討,
機能的脳神経外科, Vol.50, 150-153, 2011年.

(キーワード): X連鎖ジストニアパーキンソニズム / DYT3 / 臨床症状 / 日常生活動作 / 線条体コンパートメント構造
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571135651154880768

(CiNii: 1571135651154880768) Ryoma Morigaki, Wataru Sako, Shinya Okita, Jiro Kasahara, Hironori Yokoyama, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Cyclin-dependent kinase 5 with phosphorylation of tyrosine 15 residue is enriched in striatal matrix compartment in adult mice,
Neuroscience, Vol.189, 25-31, 2011.

(要約): Accumulating evidence suggests that the striosome-matrix systems have a tight link with motor and behavioral brain functions and their disorders. Cyclin-dependent kinase 5 (Cdk5) is a versatile protein kinase that plays a role in synaptic functions and cell survival in adult brain, and its kinase activity is stimulated by phosphorylation at tyrosine 15 residue (pY15). In this study, we used an immunohistochemical method to show differential localization of Cdk5-pY15 in the striatal compartments of adult mice, with a heightened density of Cdk5-pY15 labeling in the matrix relative to the striosomes. Our findings indicate that Cdk5-pY15 can be a new marker for the striatal matrix compartment, and suggest a possible involvement of Cdk5-mediated signaling in compartment-specific neurotransmission and disease pathology in the striatum.
(キーワード): Animals / Corpus Striatum / Cyclin-Dependent Kinase 5 / 免疫組織化学 (immunohistochemistry) / Mice / リン酸化 (phosphorylation) / Tyrosine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.neuroscience.2011.05.055
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21640796; ● Summary page in Scopus @ Elsevier: 2-s2.0-79960905477

(DOI: 10.1016/j.neuroscience.2011.05.055, PubMed: 21640796, Elsevier: Scopus) Wataru Sako, Ryoma Morigaki, Ryuji Kaji, Ikuo Tooyama, Shinya Okita, Keiko Kitazato, Shinji Nagahiro, M Ann Graybiel and Satoshi Goto :
Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia,
Neuroscience, Vol.189, 100-107, 2011.

(要約): The neuron-specific isoform of the TAF1 gene (N-TAF1) is thought to be involved in the pathogenesis of DYT3 dystonia, which leads to progressive neurodegeneration in the striatum. To determine the expression pattern of N-TAF1 transcripts, we developed a specific monoclonal antibody against the N-TAF1 protein. Here we show that in the rat brain, N-TAF1 protein appears as a nuclear protein within subsets of neurons in multiple brain regions. Of particular interest is that in the striatum, the nuclei possessing N-TAF1 protein are largely within medium spiny neurons, and they are distributed preferentially, though not exclusively, in the striosome compartment. The compartmental preference and cell type-selective distribution of N-TAF1 protein in the striatum are strikingly similar to the patterns of neuronal loss in the striatum of DYT3 patients. Our findings suggest that the distribution of N-TAF1 protein could represent a key molecular characteristic contributing to the pattern of striatal degeneration in DYT3 dystonia.
(キーワード): Amino Acid Sequence / Animals / Base Sequence / 脳 (brain) / Corpus Striatum / Dystonia / Histone Acetyltransferases / Molecular Sequence Data / Nuclear Proteins / Protein Isoforms / Rats / Rats, Sprague-Dawley / TATA-Binding Protein Associated Factors / Transcription Factor TFIID
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.neuroscience.2011.05.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21616129; ● Summary page in Scopus @ Elsevier: 2-s2.0-79960914214

(DOI: 10.1016/j.neuroscience.2011.05.031, PubMed: 21616129, Elsevier: Scopus) Ryoma Morigaki, Kyong-Hon Pooh and Yoshinobu Nakagawa :
Endoscopic transaqueductal placement of a single-catheter cyst-ventriculoperitoneal shunt in a neonate with Dandy-Walker malformation-associated hydrocephalus: case report.,
Neurologia Medico-Chirurgica, Vol.51, No.3, 256-259, 2011.

(要約): A neonate with hydrocephalus associated with Dandy-Walker malformation was successfully treated with an endoscopic placement of a transaqueductal ventricular single catheter. The modified catheter was provided with additional fenestration on its proximal side to allow simultaneous drainage from both the supra- and infratentorial compartments. This technique is well known for isolated fourth ventricles, but has not been applied to hydrocephalus associated with Dandy-Walker malformation. The cyst-ventriculoperitoneal shunt effectively drained both compartments. The patient was doing well 18 months after the surgical procedure. Endoscopic transaqueductal shunt placement can be considered, especially in patients with aqueductal patency.
(キーワード): Catheters, Indwelling / Cerebral Aqueduct / Dandy-Walker Syndrome / Humans / Hydrocephalus / Infant / Infant, Newborn / Male / Neuroendoscopy / Treatment Outcome / Ventriculoperitoneal Shunt / Ventriculostomy
(出版サイトへのリンク): ● Publication site (DOI): 10.2176/nmc.51.256
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21441750; ● Search Scopus @ Elsevier (PMID): 21441750; ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.51.256

(DOI: 10.2176/nmc.51.256, PubMed: 21441750) Wataru Sako, Ryoma Morigaki, Yoshifumi Mizobuchi, Takashi Tsuzuki, Hiroyuki Ima, Y Ushio, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Bilateral pallidal deep brain stimulation in primary Meige syndrome,
Parkinsonism & Related Disorders, Vol.17, No.2, 123-125, 2011.

(要約): Primary Meige syndrome is an idiopathic movement disorder that manifests as craniofacial and often cervical dystonias. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as a powerful surgical option in the treatment of primary generalized or segmental dystonia. However, the experience with GPi-DBS in Meige syndrome is limited. We followed 5 patients with disabling Meige syndrome treated by bilateral GPi-DBS for 49 ± 43.7 (mean ± SD) months. All patients were assessed before surgery and at the last follow-up after surgery using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) which includes both the movement and disability scales. Bilateral GPi-DBS produced a sustained and long-lasting improvement in dystonia symptoms associated with Meige syndrome. At the last follow-up, the mean scores of BFMDRS movement and disability scales improved significantly by 84 ± 6.8% (range, 75-94%) and 89 ± 8.1% (range, 80-100%), respectively. Bilateral pallidal stimulation is a beneficial therapeutic option for long-term relief of the disabling dystonia symptoms in Meige syndrome.
(キーワード): Aged / Deep Brain Stimulation / Female / Globus Pallidus / Humans / Male / Meige Syndrome / Middle Aged / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.parkreldis.2010.11.013
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21147544; ● Search Scopus @ Elsevier (PMID): 21147544; ● Search Scopus @ Elsevier (DOI): 10.1016/j.parkreldis.2010.11.013

(DOI: 10.1016/j.parkreldis.2010.11.013, PubMed: 21147544) Ryoma Morigaki, Kiyohito Shinno, Kyong-Hon Pooh and Yoshinobu Nakagawa :
Giant glioependymal cyst in an infant.,
Journal of Neurosurgery. Pediatrics, Vol.7, No.2, 175-178, 2011.

(要約): The authors report the case of an infant with a giant glioependymal cyst. Although it has been suggested that these cysts originate from the tela choroidea, their origin remains controversial. This 35-month-old girl with truncal ataxia was referred to the authors' hospital. Magnetic resonance imaging revealed a giant cystic mass extending from the anterior to the posterior cranial fossa. Hydrocephalus was caused by obstruction of the sylvian aqueduct. Endoscopic fenestration of the cyst wall was performed. Histochemical and immunohistochemical staining identified the lesion as a glioependymal cyst. Magnetic resonance imaging performed 8 months later suggested that the cyst originated from the tela choroidea. At 5-year follow-up, there was no tumor recurrence and she had fully recovered. The origin of glioependymal cysts is discussed, and the authors suggest that their origin is the tela choroidea.
(キーワード): Brain Diseases / Central Nervous System Cysts / Child, Preschool / Ependyma / Female / Humans
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/2010.11.PEDS10270
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21284464; ● Search Scopus @ Elsevier (PMID): 21284464; ● Search Scopus @ Elsevier (DOI): 10.3171/2010.11.PEDS10270

(DOI: 10.3171/2010.11.PEDS10270, PubMed: 21284464) 佐光亘, 森垣龍馬, 宮本亮介, 梶龍兒, 溝渕桂史, 永廣信治, 後藤惠 :
-dropped head syndrome,
機能的脳神経外科, Vol.50, No.2, 115-118, 2011年. Wataru Sako, Ryoma Morigaki, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto :
Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice,
Neuroscience, Vol.170, No.2, 497-502, 2010.

(要約): There is a growing body of evidence that striosome-matrix dopamine systems are tightly linked with motor and behavioral brain functions and disorders. In this study, we used an immunohistochemical method to show differential expression of the olfactory type G-protein alpha subunit (Galphaolf) that involves in the coupling of dopamine D1 receptor with adenylyl cyclase in the striatal compartments of adult mice, and observed heightened density of Galphaolf labeling in the striosomes relative to the matrix compartment. Our findings suggest that Galphaolf could be one of the key molecules for controlling differential responses of the striosome and matrix compartments to dopamine D1 receptor signaling in the striatum of adult mice.
(キーワード): Animals / Apomorphine / Corpus Striatum / Dopamine / Dopamine and cAMP-Regulated Phosphoprotein 32 / GTP-Binding Protein alpha Subunits / Mice / Neurons / Receptors, Dopamine D1 / Receptors, Opioid, mu / Signal Transduction / Tyrosine 3-Monooxygenase
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.neuroscience.2010.06.072
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20603191; ● Summary page in Scopus @ Elsevier: 2-s2.0-77956189821

(DOI: 10.1016/j.neuroscience.2010.06.072, PubMed: 20603191, Elsevier: Scopus) 佐光亘, 村瀬永子, 溝渕佳史, 森垣龍馬, 松﨑和仁, 永廣信治, 梶龍兒, 後藤惠 :
Meige 症候群に対する両側淡蒼球刺激術,
機能的脳神経外科, Vol.49, No.1, 94-95, 2010年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571417124978153088

(CiNii: 1571417124978153088) Ryoma Morigaki, Masaaki Uno, Shunji Matsubara, Koichi Satoh and Shinji Nagahiro :
Choreoathetosis due to rupture of a distal accessory anterior cerebral artery aneurysm,
Cerebrovascular Diseases, Vol.25, No.3, 285-287, 2008.

(キーワード): Aged / Aneurysm, Ruptured / Anterior Cerebral Artery / Athetosis / Cerebral Angiography / Chorea / Craniotomy / Embolization, Therapeutic / Female / Humans / Intracranial Aneurysm / Subarachnoid Hemorrhage / Tomography, X-Ray Computed / Vasodilator Agents
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000119640
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18332626; ● Search Scopus @ Elsevier (PMID): 18332626; ● Search Scopus @ Elsevier (DOI): 10.1159/000119640

(DOI: 10.1159/000119640, PubMed: 18332626) Ryoma Morigaki, Masaaki Uno, Atsuhiko Suzue and Shinji Nagahiro :
Hemichorea due to hemodynamic ischemia associated with extracranial carotid artery stenosis. Report of two cases.,
Journal of Neurosurgery, Vol.105, No.1, 142-147, 2006.

(要約): In this paper the authors describe two patients with recurrent hemiparesis and limb shaking that gradually progressed to hemichorea. Cerebral angiography confirmed severe unilateral internal carotid artery stenosis (95%) contralateral to the hemichorea. The cerebral blood flow, assessed using N-isopropyl-p-(iodine-123) iodoamphetamine single-photon emission computed tomography (SPECT), disclosed markedly decreased vascular reserves in both patients. After carotid endarterectomy was performed, the hemichorea gradually subsided and SPECT confirmed increased cerebral perfusion. The results in these cases indicate that surgical revascularization is effective for hemichorea due to cerebral ischemia with reduced vascular reserve.
(キーワード): Aged / Brain Ischemia / Carotid Artery, Internal / Carotid Stenosis / Chorea / Endarterectomy, Carotid / Female / Humans / Male
(出版サイトへのリンク): ● Publication site (DOI): 10.3171/jns.2006.105.1.142
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16871890; ● Search Scopus @ Elsevier (PMID): 16871890; ● Search Scopus @ Elsevier (DOI): 10.3171/jns.2006.105.1.142

(DOI: 10.3171/jns.2006.105.1.142, PubMed: 16871890) S Kudo, Ryoma Morigaki, J Saito, M Ikeda, K Oka and K Tanishita :
Shear-stress effect on mitochondrial membrane potential and albumin uptake in cultured endothelial cells.,
Biochemical and Biophysical Research Communications, Vol.270, No.2, 616-621, 2000.

(要約): Endothelial cells (ECs) that line the inner surface of blood vessels are continuously exposed to shear stress induced by blood flow in vivo, and shear stress affects ATP-dependent macromolecular transport in ECs. However, the relationship between the ATP production and shear stress is still unclear. We, therefore, evaluated mitochondrial ATP synthesis activity in cultured endothelial cells exposed to shear stress, using a confocal laser scanning microscope (CLSM) and a mitochondrial membrane potential probe (5,5',6,6'-tetrachloro-1,1',3, 3'-tetraethyl-benzimidazolycarbocyanine iodide, JC-1). Low shear stress (10 dyn/cm(2)) increased mitochondrial membrane potential by 30%. On the contrary, high shear stress (60 dyn/cm(2)) decreased it by 20%. This observation was consistent with the ATP-dependent albumin uptake into endothelial cells. Our results indicate that ATP synthetic activity is related to the albumin uptake into endothelial cells.
(キーワード): Adenosine Triphosphate / Albumins / Animals / Benzimidazoles / Carbocyanines / Cells, Cultured / Endothelium, Vascular / Fluorescent Dyes / Membrane Potentials / Stress, Mechanical / Swine
(出版サイトへのリンク): ● Publication site (DOI): 10.1006/bbrc.2000.2482
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10753672; ● Search Scopus @ Elsevier (PMID): 10753672; ● Search Scopus @ Elsevier (DOI): 10.1006/bbrc.2000.2482

(DOI: 10.1006/bbrc.2000.2482, PubMed: 10753672)

MISC

小山広士, 大北真哉, 牟礼英生, 森垣龍馬, 梶龍兒, 後藤惠, 永廣信治 :
症例報告第17回若手奨励賞受賞論文遅発性ジストニア(tardive dystonia)に対して脳深部刺激術を施行した5例,
四国医学雑誌, Vol.73, No.3 4, 193, 2017年.

(要約): We assessed the efficiency of pallidal deep brain stimulation for tardive dystonia. This search was carried out in Electronic chart of Tokushima University Hospital. 5 patients with tardive dystonia were enrolled. GPi(internal segment of globus pallidus)was the target in all patients. The motor part of Burke-Fahn-Marsden Dystonia Rating Scale(BFMDRS)was improved by 78．4% on average when compared to preoperative BFMDRS scores. The performed analysis indicates that GPi-DBS is an effective and safe treatment for tardive dystonia.
(キーワード): deep brain stimulation / globus pallidus internus / tardive dyskinesia / tardive syndrome / Burke-Fahn-Marsden dystonia rating scale(BFMDRS)
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564287419680128

(CiNii: 1050564287419680128) 佐光亘, 梶龍兒, 宮本亮介, 森垣龍馬, 溝渕佳史, 永廣信治, 後藤惠 :
薬物療法を中心としたジストニア治療戦略,
機能的脳神経外科, Vol.50, No.1, 36-37, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573387449814655232

(CiNii: 1573387449814655232) 佐光亘, 森垣龍馬, 都築貴, 井間博之, 生塩之敬, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠 :
原発性 Meige 症候群に対する両側淡蒼球刺激術 : 罹患部位による反応の相違,
機能的脳神経外科, Vol.50, No.1, 46-47, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572824499861230208

(CiNii: 1572824499861230208) 森垣龍馬, 佐光亘, 溝渕佳史, 永廣信治, 後藤惠, 梶龍兒 :
X-linked dystonia-parkinsonism 患者の臨床症状の検討,
機能的脳神経外科, Vol.50, No.1, 48-49, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1571417124977670272

(CiNii: 1571417124977670272) 佐光亘, 宮本亮介, 梶龍兒, 森垣龍馬, 溝渕佳史, 永廣信治, 後藤惠 :
パーキンソン病における dropped head syndrome に対する両側視床下核刺激術の治療効果,
機能的脳神経外科, Vol.50, No.1, 108-109, 2011年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261549908102016

(CiNii: 1572261549908102016) 佐光亘, 森垣龍馬, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠 :
Meige症候群に対する両側淡蒼球刺激術,
機能的脳神経外科, Vol.49, No.2, 148-151, 2010年.

(キーワード): *Meige症候群(合併症,外科的療法) / *淡蒼球 / 発病年齢 / 顔面けいれん(病因) / *脳深部刺激 / ヒト / 成人(19∼44) / 中年(45∼64) / 高齢者(65∼79) / 男 / 女
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573105974837985664

(CiNii: 1573105974837985664) 佐光亘, 村瀬永子, 溝渕佳史, 森垣龍馬, 松﨑和仁, 永廣信治, 梶龍兒, 後藤惠 :
Focal hand dystonia に対する視床 Vo-complex 破壊術と淡蒼球刺激術,
機能的脳神経外科, Vol.49, No.1, 98-99, 2010年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1574231874745267840

(CiNii: 1574231874745267840) 森垣龍馬, 宇野昌明, 松原俊二, 佐藤浩一, 鈴江淳彦, 溝渕佳史, 佐光亘, 梶龍兒, 永廣信治, 後藤惠 :
その他の不随意運動脳血管障害による不随意運動の3症例,
機能的脳神経外科, Vol.49, No.1, 60-61, 2010年.

(キーワード): 塞栓術 / *脳血管障害(合併症,外科的療法) / 舞踏病(病因) / 頸動脈内膜切除術 / *不随意運動 / コイルドコイルモチーフ (coiled-coil motif) / ヒト (Homo sapiens) / 高齢者(65∼79) / 男 / 女
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1572261549908344832

(CiNii: 1572261549908344832) Ryoma Morigaki, Masahito Nakataki, Toshitaka Kawarai, Lillian V. Lee, Rosalia A. Teleg, Ma Daisy P. Tabuena, Hideo Mure, Wataru Sako, Paul Matthew D. Pasco, Shinji Nagahiro, Junichi Iga, Tetsuro Ohmori, Satoshi Goto and Ryuji Kaji :
Depression in X-linked dystonia-parkinsonism:A case-control study,
Parkinsonism & Related Disorders, Vol.19, No.9, 844-846, 2013.

(キーワード): Case-Control Studies / Depression / Dystonic Disorders / Genetic Diseases, X-Linked / Heredodegenerative Disorders, Nervous System / Humans / Male / Parkinson Disease
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.parkreldis.2013.04.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23706616; ● Summary page in Scopus @ Elsevier: 2-s2.0-84880785140

(DOI: 10.1016/j.parkreldis.2013.04.027, PubMed: 23706616, Elsevier: Scopus)

総説・解説

Ryoma Morigaki and Ryosuke Miyamoto :
Dystonia: Still a Mysterious Syndrome.,
Life, Vol.12, No.7, Jul. 2022.

(要約): The diagnosis of dystonia is sometimes complicated due to its many clinical manifestations, causes, and the lack of specific diagnostic examinations or simple algorithms [...].
(徳島大学機関リポジトリ): ● Metadata: 117342
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/life12070989
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35888079; ● Search Scopus @ Elsevier (PMID): 35888079; ● Search Scopus @ Elsevier (DOI): 10.3390/life12070989

(徳島大学機関リポジトリ: 117342, DOI: 10.3390/life12070989, PubMed: 35888079) 森垣龍馬, 後藤惠 :
ジストニアの脳内機序ー病理所見ー,
Modern Physicaion 特集ジストニアとジスキネジア, Vol.37, No.6, 586-588, 2017年6月. Ryoma Morigaki and Satoshi Goto :
A short commentary on globus pallidus internus deep brain stimulation in primary Meige syndrome,
Journal of Neurology & Neurophysiology, Vol.7, No.6, 2016.

(徳島大学機関リポジトリ): ● Metadata: 114297
(出版サイトへのリンク): ● Publication site (DOI): 10.4172/2155-9562.1000405
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.4172/2155-9562.1000405

(徳島大学機関リポジトリ: 114297, DOI: 10.4172/2155-9562.1000405) 森垣龍馬, 梶龍兒 :
不随意運動,
日本医師会雑誌, Vol.142, No.2, 95-96, 2013年10月.

講演・発表

Taku Matsuda, Ryoma Morigaki, Hiroaki Hayasawa, Hiroshi Koyama, Teruo Oda, Kazuhisa Miyake and Yasushi Takagi :
Striatal parvalbumin interneurons, not cholinergic interneurons, are activated in a mouse model of cerebellar dystonia,
NEURO2024, Fukuoka, Jul. 2024. Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi :
Cranial geometry in patients with dystonia,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. NAKANISHI Hiroshi, Ryoma Morigaki, Nobuaki Yamamoto, Joji Fujikawa, Teruo Oda, OMAE Hiroshi, Yuishin Izumi and Yasushi Takagi :
The effect of Rikaba, a hybrid physical exercise salon for Parkinson's disease patients,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama and Yasushi Takagi :
Long-term follow-up of 12 patients treated with bilateral pallidal stimulation for tardive dystonia,
13th Scientific meeting of Asian Australasian Society for Streotactic and Functional Neurosurgery, Osaka, Apr. 2023. OMAE Hiroshi, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, 中野渡友香, Megumi Kuno, Tetsuya Matsuura and Yasushi Takagi :
Cognitive changes due to subthalamic nucleus deep brain stimulation in elderly Parkinson's Disease,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Ryoma Morigaki, Maya Anzai, Joji Fujikawa, Teruo Oda, Hayasawa Hiroaki, Matsuda Taku, Jiro Kasahara and Yasushi Takagi :
Changes in phosphodiesterase 10A in mice model of levodopa-induced dyskinesia,
The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023. Harumi Kadota, Shoma Fujisawa, Masaki Oono, Ryoma Morigaki, Nobuaki Yamamoto, Yasuhisa Kanematsu, Manabu Ishihara and Masami Shishibori :
Development of a 3D visualization system for the cerebral aneurysm coil embolization,
Proceedings Volume 11794, Fifteenth International Conference on Quality Control by Artificial Vision; 117940C (2021), Tokushima, Jul. 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1117/12.2589084
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1117/12.2589084

(DOI: 10.1117/12.2589084) Ryoma Morigaki, Masatoshi Ogawa, Shinya Ohkita, Taku Matsuda, Yasushi Takagi and Satoshi Goto :
Phospho-serine 276 of nuclear factor kappa b is involved in the genesis of l-dopa-induced dyskinesia,
The Journal of Neuroscience, 2021. Ryoma Morigaki, Lee H Janifer, Yoshida Tomoko, Wuthrich Christian and Graybiel M Ann :
Mu opioid receptors are strongly upregulated in the q175 mouse model of huntingtons disease,
The Journal of Neuroscience, Chicago, IL, Oct. 2019. Ryoma Morigaki, S Okita, Hideo Mure, Yasushi Takagi and S Goto :
Olfactory type g-protein alfa subunit related changes in the striatum underlie the genesis of L-DOPA induced dyskinesiaBrain and Brain PET2019,
Brain and Brain PET2019, Jul. 2019. Ryoma Morigaki, Shinya Ohkita, Hideo Mure, Yasushi Takagi and Satoshi Goto :
Olfactory type G-protein alfa subunit related changes in the striatum underlie the genesis of L-dopa-induced dyskinesia,
Journal of Cerebral Blood Flow and Metabolism, Yokohama, Jun. 2019. Hideo Mure, Ryoma Morigaki, Shinya Ohkita, Ryosuke Miyamoto, Shinji Nagahiro and Satoshi Goto :
Deep Brain Stimulation for Dystonia - Pallidal stimulation and thalamic stimulation,
World Society for Stereotactic and Functional Neurosurgery, Berlin, Jun. 2017. Toshitaka Kawarai, Ryosuke Miyamoto, Hideo Mure, Ryoma Morigaki, Orlacchio Antonio, Koichihara Reiko, Nakagawa Eiji, Takashi Sakamoto, Yuishin Izumi, Satoshi Goto and Ryuji Kaji :
Haploinsufficiency of KMT2B causes myoclonus-dystonia with impaired psychomotor ability,
The MDS 21th International Congress of Parkinsons Disease and Movement Disorders, Jun. 2017.

(キーワード): KMT2B / dystonia

Jiro Kasahara, Yamamura Yukio, Tanabe Akie, Ryoma Morigaki, Ryuji Kaji and Satoshi Goto :
Inhibition of c-Abelson tyrosine kinase (c-Abl) as a possible strategy for treatment of PD: Study in MPTP-induced mice model,
The 12th International Conference on Alzheimers's and Parkinson;s Disease: AD/PD 2015, Mar. 2015. Nobuaki Yamamoto, Yuka Terasawa, Junichiro Satomi, Ryoma Morigaki, Koji Fujita, Masafumi Harada, Yuishin Izumi, Shinji Nagahiro and Ryuji Kaji :
Reversibility of ischemic findings on 3-tesla magnetic resonance T2*-weighted image after recanalization,
European Stroke Conference 2014, Nice, France, May 2014. Yoshifumi Mizobuchi, T Okazaki, Teruyoshi Kageji, Kazuyuki Kuwayama, KT Kitazato, Hideo Mure, Keijiro Hara, Ryoma Morigaki, Kazuhito Matsuzaki, Kohhei Nakajima, T Fujihara and Shinji Nagahiro :
A combination of interferon-beta and temozolomide augments anti-tumor effects through p73/YAP-mediated apoptosis by PML in glioblastoma,
The 4th Quadrennial Meeting of the World Federation of Neuro-Oncology held in conjunction with the 2013 SNO Scientific Meeting and Education Day, San Francisco, Nov. 2013. Junichiro Satomi, Shinji Nagahiro, Shunji Matsubara, Masaaki Uno, Koichi Satoh, Norio Nakajima, Kohhei Nakajima, Kyoko Nishi and Ryoma Morigaki :
Combined treatment for intracranial giant aneurysms,
9th International Conference on Cerebrovascular Surgery, Nagoya, Nov. 2009. 森垣龍馬, 中西浩史, 小田輝王, 藤川丈自, 大前博司, 河原崎貴光, 山本伸昭, 立花亜由美, 尾崎智樹, 伊賀淳一, 髙木康志 :
多職種連携によりパーキンソン病患者用サロンから開発した介護医療補助システム,
日本脳神経外科学会第83回学術総会, 2024年10月. 森垣龍馬 :
凝固術と脳深部刺激療法の現状,
第43回日本脳神経超音波学会総会/第27回日本栓子検出と治療学会, 2024年6月. 藤川丈自, 三宅一央, 森垣龍馬 :
脳深部刺激電極から得たLFPの解析(初級編),
第6回中国四国機能神経外科懇話会, 2024年3月. 三宅一央, 森垣龍馬, 髙木康志 :
脳深部刺激療法における電極の移動に関する2報告,
第6回中国四国機能神経外科懇話会, 2024年3月. 森垣龍馬, 三宅一央, 松田拓, 髙木康志 :
赤核振戦に伴う痛みに対して著効した脳深部刺激療法の一例,
第6回中国四国機能神経外科懇話会, 2024年3月. 森垣龍馬 :
若手に知ってほしい不随意運動症基礎研究の魅力,
第63回日本定位・機能神経外科学会, 2024年2月. 森垣龍馬, 三宅一央, 宮本亮介, 大前博司, 松田拓, 小山広士, 和泉唯信, 髙木康志 :
GPi-DBSが著効した外転型痙攣性発声障害の一例,
第63回日本定位機能外科学会, 2024年2月. 大前博司, 森垣龍馬, 三宅一央, 松田拓, 中野渡友香, 久野恵, 松浦哲也, 髙木康志 :
高齢パーキンソン病患者に対する視床下核脳深部刺激療法による変化の検討,
第36回日本老年脳神経外科学会, 2023年4月. 森垣龍馬, 三宅一央, 松田拓, 小山広士, 宮本亮介, 和泉唯信, 中瀧理仁, 梶龍兒, 後藤惠, 髙木康志 :
機能性要素を合併したジストニア症例への手術加療をどう考えるか,
第62回日本定位・機能神経外科学会, 2023年1月. 森垣龍馬, 三宅一央, 小山広士, 松田拓, 髙木康志 :
STN-DBS術後にpainful abdominal contractionとbelly dancer's dyskinesiaを呈したパーキンソン病患者の一例,
第62回日本定位・機能神経外科学会, 2023年1月. 三宅一央, 森垣龍馬, 松田拓, 髙木康志 :
GPi-DBSのinterleaving刺激により，パーキンソン病でのすくみ足に効果を認めた一例,
日本脳神経外科学会第81回学術総会, 2022年9月. 森垣龍馬, 三宅一央, 松田拓, 宮本亮介, 和泉唯信, 中瀧理仁, 髙木康志 :
機能性要素を合併したジストニアへの手術加療,
日本脳神経外科学会第81回学術総会, 2022年9月. 森垣龍馬 :
教育コースジストニアを究める機能性ジストニア治療法としての外科的な治療ーDBS刺激の調整も含めて,
日本神経学会誌, 2022年5月. 山本伸昭, 黒田一駿, 山本雄貴, 兼松康久, 森垣龍馬, 和泉唯信, 髙木康志 :
脳主幹動脈閉塞に対する血行再建術において有効再開通が得られた患者の予後関連因子,
第63回日本神経学会学術大会, 2022年5月. 三宅一央, 森垣龍馬, 牟礼英生, 松田拓, 後藤惠, 髙木康志 :
Vo-DBS施行後から9年経過したDYT6ジストニア患者の長期予後,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
日本定位・機能神経外科学会機関紙, 2022年1月. 森垣龍馬, 藤川丈自, 松田拓, 三宅一央, 牟礼英生, 小田輝王, 宮本亮介, 藤田浩司, 山本伸昭, 和泉唯心, 髙木康志 :
特発性ジストニア患者の頭蓋骨の歪み,
日本定位・機能神経外科学会機関紙, 2022年1月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 原田雅史, 髙木康志 :
全身性ジストニアと強迫性障害の重症度についての検討,
第61回日本定位・機能神経外科学会, 2022年1月. 石原学, 兼松康久, 中西信人, 森垣龍馬, 山本伸昭, 大藤純, 獅々堀正幹, 髙木康志 :
日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討機械学習(データマイニング)を用いた解析,
日本脳神経外科学会学術総会, 2021年10月. 松田拓, 森垣龍馬, 松元友暉, 牟礼英生, 三宅一央, 中瀧理仁, 髙木康志 :
全身性ジストニアの重症度と強迫観念の関係性についての検討,
日本脳神経外科学会学術総会, 2021年10月. 三宅一央, 森垣龍馬, 牟礼英生, 髙木康志 :
DYT6ジストニア患者におけるDBS術後9年の長期予後,
日本脳神経外科学会学術総会, 2021年10月. 森垣龍馬, 藤川丈自, 小田輝王, 中西浩, 山本伸昭, 三宅一央, 松田拓, 髙木康志 :
機械学習を用いた脳線条体免疫染色画像の解析,
日本脳神経外科学会学術総会, 2021年10月. 森垣龍馬, 四方英二, 三宅一央, 松田拓, 髙木康志 :
神経刺激装置埋め込み術後の皮下血腫に対し漢方薬が奏功した3例,
第29回日本脳神経外科漢方医学会学術集会, 2021年10月. 石原学, 中西信人, 兼松康久, 森垣龍馬, 山本伸昭, 髙木康志, 大藤純 :
日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討,
日本集中治療医学会雑誌, 2021年2月. 森垣龍馬, 牟礼英生, 松田拓, 三宅一央, 宮本亮介, 藤田浩司, 中瀧理仁, 梶龍兒, 髙木康志, 後藤惠 :
機能ー器質ボーダーラインジストニアに対する脳深部刺激療法,
第60回日本定位・機能神経外科学会, 2021年1月. 牟礼英生, 森垣龍馬, 小山広士, 三宅一央, 松田拓, 宮本亮介, 藤田浩司, 和泉唯信, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討ー適応・長期成績・刺激条件についてー,
第60回日本定位・機能神経外科学会, 2021年1月. 三宅一央, 松田拓, 森垣龍馬, 牟礼英生, 髙木康志, 宮本亮介 :
ジストニックストームを生じたGNAO1遺伝子変異に対し淡蒼球脳深部刺激療法を行った1例,
第60回日本定位・機能神経外科学会, 2021年1月. 松田拓, 松元友暉, 森垣龍馬, 牟礼英生, 三宅一央, 加藤真介, 尾藤良孝, 原田雅史, 髙木康志 :
Quantitative parameter mappingを用いた3TMRIでの視床下核の可視化,
第60回日本定位・機能神経外科学会, 2021年1月. 石原学, 竹村星哉, 兼松康久, 森垣龍馬, 山本伸昭, 大藤純, 大野将樹, 獅々堀正幹, 髙木康志 :
機械的学習を用いた医療データの解析脳出血症例の検討,
第79回日本脳神経外科学会学術総会, 2020年10月. 牟礼英生, 森垣龍馬, 小山広士, 大北真哉, 松田拓, 佐光亘, 宮本亮介, 藤田浩司, 和泉唯信, 梶龍兒, 後藤惠, 髙木康志 :
遅発性ジストニアに対する淡蒼球内節刺激術12例の検討:適応・長期成績・刺激条件について,
第79回日本脳神経外科学会総会, 2020年10月. 森垣龍馬, 吉田智子, Wuthrich Christian, Crittenden R. Jill, 久保田康夫, Graybiel M. Ann :
Q175ハンチントン病モデルマウス線条体においてmu-オピオイド受容体の発現は進行性に強く増加する,
第79回日本脳神経外科学会学術総会, 2020年10月. 宮本亮介, 黒田一駿, 牟礼英生, 森垣龍馬, 中瀧理仁, 大崎裕亮, 和泉唯信, 後藤惠, 梶龍兒 :
18p-症候群に伴う全身性ジストニアに対し，GPi-DBSが効果的であった一例,
第61回日本神経学会学術大会, 2020年8月. 松田拓, 森垣龍馬, 牟礼英生, 中瀧理仁, 山本陽子, 豊田直人, 後藤惠, 髙木康志 :
ジストニアと強迫性障害の関係についての検討,
機能的脳神経外科, 130, 2020年1月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 松田拓, 後藤惠, 髙木康志, 後藤惠 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
機能的脳神経外科, 132, 2020年1月. 森垣龍馬, 牟礼英生, 松田拓, 宮本亮介, 山本陽子, 豊田直人, 髙木康志, 後藤惠 :
GPi-DBSを施行したDYT-GNAL(DYT25)の一例,
機能的脳神経外科, 134, 2020年1月. 宮本亮介, 藤田浩司, 牟礼英生, 森垣龍馬, 中瀧理仁, 和泉唯信, 後藤惠, 梶龍兒 :
ヒステリー性麻痺の臨床診断と電気生理心因性運動障害の診断心因性ジストニアを中心に,
第49回日本臨床神経生理学会学術大会, 2019年11月. 森垣龍馬, 牟礼英生, 宮本亮介, 松田拓, 山本陽子, 髙木康志, 後藤惠 :
機能性ジストニアは器質性ジストニアスペクトラム障害か?,
Neurologia Medico-Chirurgica, 349, 2019年10月. 牟礼英生, 藤田浩司, 森垣龍馬, 宮本亮介, 後藤惠, 髙木康志 :
FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出,
日本脳神経外科学会第78回学術集会, 2019年10月. 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 髙木康志, 梶龍兒, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携．,
第57回日本定位・機能神経外科学会, 2018年1月. 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 岡久哲也, 髙木康志, 梶龍兒, 永廣信治, 後藤惠 :
ジストニアDBS治療における多職種連携,
第57回日本定位・機能神経外科学会, 2018年1月. 牟礼英生, 森垣龍馬, 宮本亮介, 中瀧理仁, 里見淳一郎, 梶龍兒, 後藤惠, 永廣信治 :
ジストニアDBS治療におけるチーム医療の重要性 -徳島大学での取り組み-,
日本脳神経外科学会第76回学術総会, 2017年10月. 森垣龍馬, 大北真哉, 牟礼英生, 永廣信治, 後藤惠 :
L-ドーパ誘発性ジスキネジア発症におけるGαolf発現の変化,
日本脳神経外科学会第76回学術総会, 2017年10月. 亘雄也, 牟礼英生, 森垣龍馬, 大北真哉, 西山徹, 永廣信治 :
Lance-Adams症候群に対する両側淡蒼球内節刺激術の一施行例,
第83回日本脳神経外科学会中国四国支部学術集会, 2017年4月. 牟礼英生, 大北真哉, 森垣龍馬, 後藤惠, 永廣信治 :
小児ジストニアに対する脳深部刺激療法の経験,
第21回四国脳神経外科カンファレンス, 2016年8月. 大北真哉, 森垣龍馬, 牟礼英生, 兼松康久, 宮本亮介, 永廣信治, 梶龍兒, 後藤惠, 亘雄也, 谷口秀和, 夫敬憲, 中川義信 :
脳性麻痺に合併した全身性ジストニアに対し脳深部刺激術を施行した1例,
第55回日本定位・機能神経外科学会, 2016年1月. 牟礼英生, 森垣龍馬, 大北真哉, 小泉英期, 永廣信治, 梶龍兒, 後藤惠 :
ジストニアに対するDBS-淡蒼球刺激と視床刺激の併用-,
第55回日本定位・機能神経外科学会, 2016年1月. 森垣龍馬, 宮本亮介, 大北真哉, 溝渕佳史, 牟礼英生, 永廣信治, 梶龍兒, 後藤惠 :
NFκBのマウス脳線条体における発現パターンとその役割,
第55回日本定位・機能神経外科学会, 2016年1月. Ryoma Morigaki, Satoshi Goto and Ryuji Kaji :
Neuropathology of X-linked dystonia parkinsonism,
Clinical Neurology, Vol.56, s111, 2016. 森垣龍馬, 大北真哉, 牟礼英生, 溝渕佳史, 後藤惠, 梶龍兒, 永廣信治 :
Nuclear factor kappa bはマウス脳線条体においてドパミンシグナル支配下に機能する,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 牟礼英生, 森垣龍馬, 大北真哉, 梶龍兒, 佐光亘, 後藤惠, 永廣信治 :
Meige症候群に対する両側淡蒼球内節刺激術,
一般社団法人日本脳神経外科学会第74回学術総会, 2015年10月. 森垣龍馬, 大北真哉, 溝渕佳史, 牟礼英生, 永廣信治, 梶龍兒, 後藤惠 :
マウス脳線条体におけるNuclear factor kappa bの機能的分子としての可能性,
第16回日本分子脳神経外科学会, 2015年8月. Toshitaka Kawarai, Ryosuke Miyamoto, Tamura Asako, Takashi Abe, Funakoshi Yasuhiro, Orlacchio Antonio, Oki Ryosuke, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Yuishin Izumi, Naito Hiroshi, Tomimoto Hidekazu and Ryuji Kaji :
Germline mosaicism of TUBB4A mutation causes dystonia in two siblings.,
56th Annual Meeting of the Japanese Society of Neurology, May 2015. 大北真哉, 森垣龍馬, 牟礼英生, 松田拓, 永廣信治, 後藤惠, 梶龍兒 :
Hypomyelination with atrophy of the basal ganglia and cerebellumに対し脳深部刺激術を施行した1例,
第54回日本定位・機能神経外科学会, 2015年1月. 牟礼英生, 大北真哉, 永廣信治, 森垣龍馬, 後藤惠, 佐光亘, 梶龍兒 :
Meige症候群に対するGPi-DBS,
第54回日本定位・機能神経外科学会, 2015年1月. 山村行生, 笠原二郎, 森垣龍馬, 後藤惠 :
イマチニブのパーキンソン病治療薬としての可能性,
第53回日本薬学会中国四国支部学術大会, 2014年11月. 牟礼英生, 森垣龍馬, 大北真哉, 永廣信治, 松﨑和仁, 後藤惠 :
ジストニアに対するDBS-淡蒼球刺激と視床刺激の併用-,
第73回日本脳神経外科学会学術総会, 2014年10月. 田邉彬恵, 山村行生, 笠原二郎, 森垣龍馬, 梶龍兒, 後藤惠 :
MPTPマウスモデルにおける線条体c-Ablチロシンキナーゼを標的としたパーキンソン病治療研究,
第18回活性アミンに関するワークショップ, 2014年8月. 笠原二郎, 山村行生, 田邉彬恵, 森垣龍馬, 梶龍兒, 後藤惠 :
MPTP誘発パーキンソン病モデルマウスにおけるc-Abl阻害薬の薬効評価,
第21回カテコールアミンと神経疾患研究会, 2014年4月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
2014年脳卒中学会総会, 2014年3月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 多田恵曜, 里見淳一郎, 永廣信治 :
急性期虚血性脳卒中患者のT2*強調画像所見とその変化,
第39回日本脳卒中学会総会, 2014年3月. 山本伸昭, 寺澤由佳, 藤田浩司, 和泉唯信, 梶龍兒, 森垣龍馬, 里見淳一郎, 永廣信治, 原田雅史 :
主幹動脈閉塞に伴う虚血性脳卒中における3T-MR T2*-weighted image所見とその変化,
第16回徳島脳卒中研究会, 2014年2月. 大北真哉, 牟礼英生, 溝渕佳史, 永廣信治, 森垣龍馬, 後藤惠, 宮本亮介, 山本伸昭, 梶龍兒 :
高インスリン血性高アンモニア血性症候群に合併した全身性ジストニアに対し，脳深部刺激術を施行した1例,
第53回日本定位・機能神経外科学会, 2014年2月. 森垣龍馬, 小泉英貴, 牟礼英生, 大北真哉, 溝渕佳史, 永廣信治, 梶龍兒, 後藤惠, 瓦井俊孝 :
X-linked dystonia-parkinsonismのニューロペプタイドYシステム,
第53回日本定位・機能神経外科学会, 2014年2月. 牟礼英生, 森垣龍馬, 大北真哉, 永廣信治, 後藤惠, 小泉英貴, 梶龍兒 :
ジストニックストームにおける治療法の検討-4例の自験例と文献的考察-,
第53回日本定位・機能神経外科学会, 2014年2月. 山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠 :
ドーパミンシグナルはマウス線条体サイクリン依存性キナーゼ5 (Cdk5) のチロシン15残基リン酸化を抑制的に制御する,
第17回活性アミンに関するワークショップ, 2013年8月. 山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠 :
ドーパミンシグナルはマウス線条体サイクリン依存性キナーゼ5 (Cdk5) のチロシン15残基リン酸化を抑制的に制御する,
Neuro2013, 2013年6月. 山村行生, 森垣龍馬, 笠原二郎, 横山宏典, 田邊彬恵, 大北真哉, 小泉英貴, 永廣信治, 梶龍兒, 後藤惠 :
ドーパミンシグナルはマウス線条体サイクリン依存性キナーゼ5 (Cdk5) のチロシン15残基リン酸化を抑制的に制御する,
第20回カテコールアミンと神経疾患研究会, 2013年4月. 森垣龍馬, 中瀧理仁, 伊賀淳一, 瓦井俊孝, 牟礼英生, 溝渕佳史, 大北真哉, 大森哲郎, 永廣信治, 後藤惠, 梶龍兒 :
X-linked dystonia-parkinsonismのうつ症状,
第52回日本定位・機能神経外科学会, 2013年1月. 牟礼英生, 森垣龍馬, 大北真哉, 後藤惠, 永廣信治, 小泉英貴, 瓦井俊孝, 梶龍兒 :
両側視床Vo核刺激が奏功したDYT6の一例,
第52回日本定位・機能神経外科学会, 2013年1月. Toshitaka Kawarai, Mitsuya Morita, Ryoma Morigaki, Koji Fujita, Hiroyuki Nodera, Yuishin Izumi, Satoshi Goto, Imaharu Nakano and Ryuji Kaji :
Pathomechanisms of motor neuron death by mutant TFG.,
Clinical Neurology, Vol.23, No.11, 1199, 2013.

(要約): Mutations in TFG gene have been demonstrated in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) and hereditary spastic paraplegia (HSP). A broad spectrum of TFG pathology is suspected in motor neuron diseases including amyotrophic lateral sclerosis (ALS). We performed mutation screening of TFG gene in ALS cases and evaluated the biological functions of mutant TFG by expression experiment in cultured cells. Two missense mutations associated with sporadic ALS were discovered. Mislocalization of ALS-related proteins, including TDP-43 and optineurin, was demonstrated. These results indicate that mistrafficking of ALS-related proteins by mutant TFG might be a biological cascade leading to motor neuron death.
(キーワード): Humans / Mutation, Missense / Proteins / Spastic Paraplegia, Hereditary
(出版サイトへのリンク): ● Publication site (DOI): 10.5692/clinicalneurol.53.1199
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24291928; ● Summary page in Scopus @ Elsevier: 2-s2.0-84891811182

(DOI: 10.5692/clinicalneurol.53.1199, PubMed: 24291928, Elsevier: Scopus) 佐光亘, 村瀬永子, 溝渕圭史, 森垣龍馬, 松﨑和仁, 永廣信治, 梶龍兒, 後藤惠 :
ジストニア Focal hand dystoniaに対する視床Vo-complex破壊術と淡蒼球刺激術,
機能的脳神経外科, Vol.49, No.1, 98-99, 2010年10月.

(キーワード): *ジストニア(治療,外科的療法); 筋収縮; *淡蒼球; *手; *定位脳手術; *脳深部刺激 / *視床破壊術 / ヒト; 中年(45∼64); 男

山本伸昭, 寺澤由佳, 藤田浩司, 森垣龍馬, 里見淳一郎, 梶龍兒, 永廣信治 :
3T MRI T2強調画像におけるischemic vessel signsの検討,
第39回日本脳卒中の外科学会, 2010年4月. 里見淳一郎, 森垣龍馬, 中島公平, 八木謙次, 西京子 :
大型内頚動脈瘤に対するhigh flow bypass及び頭蓋内親動脈コイル塞栓併用療法の中長期成績,
第39回日本脳卒中の外科学会, 2010年4月. 北村弥生, 清家卓也, 橋本一郎, 中西秀樹, 森垣龍馬, 影治照喜 :
頭蓋骨に発生した動脈瘤様骨嚢腫と考えられた1例,
頭蓋骨に発生した動脈瘤様骨嚢腫と考えられた1例, 2010年2月. 森垣龍馬, 溝渕佳史, 永廣信治, 佐光亘, 梶龍兒, 後藤惠, 宇野昌明, 松原俊二, 佐藤浩一, 鈴江淳彦 :
脳血管障害による不随意運動の3症例,
第49回日本定位・機能神経外科学会, 2010年1月. 佐光亘, 村瀬永子, 溝渕圭史, 森垣龍馬, 松﨑和仁, 永廣信治, 梶龍兒, 後藤惠 :
ジストニア Meige症候群に対する両側淡蒼球刺激術,
機能的脳神経外科, Vol.49, No.1, 94-95, 2010年.

(キーワード): *Meige症候群(合併症,治療); ジストニア(病因,治療); MRI; *淡蒼球(画像診断); 発声障害(病因,治療); *脳深部刺激 / ヒト; 成人(19∼44); 中年(45∼64); 男; 女

多田恵曜, 森垣龍馬, 島田健司, 鈴江淳彦, 西京子, 宇野昌明, 永廣信治 :
急性期STA-MCA anastomosisの検討,
第36回日本脳卒中の外科学会, 2007年3月.

研究会・報告書: 森垣龍馬 :
パーキンソン病に対する薬物治療と外科的治療,
第287回名西郡・徳島西医師会学術講演会, 2020年9月. 松田拓, 鹿草宏, 梅村公子, 佐藤紀, 森垣龍馬, 牟礼英生, 兼松康久, 松元友暉, 原田雅史, 加藤真介, 髙木康志 :
ロボットスーツHALを用いた脳卒中急性期リハビリテーションの当院での取り組み,
第8回日本脳神経HAL研究会, 2020年2月. 森垣龍馬, 牟礼英生, 大北真哉, 小山広士, 宮本亮介, 梶龍兒, 後藤惠 :
心因性ジストニアは器質性ジストニアと同じスペクトラムの障害か?,
第2回中四国機能神経外科談話会, 2017年4月.

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: ふたつの異なるモデルによるジストニア発症機序と治療ターゲットの解明 (研究課題/領域番号: 23K08523 )
ジストニア新規遺伝子機能の解明 (研究課題/領域番号: 23K06929 )
線条体ストリオソーム構造をターゲットとしたジストニア新規治療法の開発 (研究課題/領域番号: 20K17932 )
ジストニアの治療ターゲット同定 (研究課題/領域番号: 20K07904 )
線条体コンパートメント構造に基づくL-ドーパ誘発性ジスキネジアの治療法開発 (研究課題/領域番号: 17K10899 )
線条体ストリオソームを標的としたL-ドーパ誘発性ジスキネジアの新たな治療法の開発（国際共同研究強化） (研究課題/領域番号: 16KK0182 )
難治性運動異常症の診断と治療前後におけるFDG-PET画像解析の有用性 (研究課題/領域番号: 16K10788 )
NFκB を分子標的としたL-ドーパ誘発性ジスキネジアの治療法開発 (研究課題/領域番号: 26461272 )
ジストニアの機能病理に関する実験的研究 (研究課題/領域番号: 26430054 )
脳動脈瘤破裂の分子機構と薬物制御 (研究課題/領域番号: 24390344 )
研究者番号（70710565）による検索

その他: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月15日更新

専門分野・研究分野: 脳神経外科 (Neurosurgery)
所属学会・所属協会: 日本脳神経外科学会
日本定位機能神経外科学会
脳神経外科コングレス
日本分子脳神経外科学会
Society for Neuroscience
日本神経科学学会
日本神経学会
International Movement Disorder Society
委員歴・役員歴: 日本分子脳神経外科学会 ( [2015年8月])
日本神経学会 ( [2021年8月])
International Movement Disorder Society ( [2023年])
受賞: 2024年1月, e-とくしま推進財団表彰 (e-とくしま推進財団)
2024年2月, 第96回日本定位機能外科学会一般口演優秀発表賞 (日本定位機能外科学会)
2024年2月, 優秀発表賞 (日本定位・機能神経外科学会)
活動: 日本医工ものづくりコモンズ (評議員 [2024年6月])

更新

Ｊグローバル

Jグローバル最終確認日: JグローバルAPIで取得できませんでした。
氏名（漢字）: JグローバルAPIで取得できませんでした。
氏名（フリガナ）: JグローバルAPIで取得できませんでした。
氏名（英字）: JグローバルAPIで取得できませんでした。
所属機関: JグローバルAPIで取得できませんでした。

リサーチマップ

researchmap最終確認日: リサーチマップAPIで取得できませんでした。
氏名（漢字）: リサーチマップAPIで取得できませんでした。
氏名（フリガナ）: リサーチマップAPIで取得できませんでした。
氏名（英字）: リサーチマップAPIで取得できませんでした。
プロフィール: リサーチマップAPIで取得できませんでした。
登録日時: リサーチマップAPIで取得できませんでした。
更新日時: リサーチマップAPIで取得できませんでした。
アバター画像URI: リサーチマップAPIで取得できませんでした。
ハンドル: リサーチマップAPIで取得できませんでした。
eメール: リサーチマップAPIで取得できませんでした。
eメール（その他）: リサーチマップAPIで取得できませんでした。
携帯メール: リサーチマップAPIで取得できませんでした。
性別: リサーチマップAPIで取得できませんでした。
没年月日: リサーチマップAPIで取得できませんでした。
所属ID: リサーチマップAPIで取得できませんでした。
所属: リサーチマップAPIで取得できませんでした。
部署: リサーチマップAPIで取得できませんでした。
職名: リサーチマップAPIで取得できませんでした。
学位: リサーチマップAPIで取得できませんでした。
学位授与機関: リサーチマップAPIで取得できませんでした。
URL: リサーチマップAPIで取得できませんでした。
科研費研究者番号: リサーチマップAPIで取得できませんでした。
Google Analytics ID: リサーチマップAPIで取得できませんでした。
ORCID ID: リサーチマップAPIで取得できませんでした。
その他の所属ID: リサーチマップAPIで取得できませんでした。
その他の所属名: リサーチマップAPIで取得できませんでした。
その他の所属部署: リサーチマップAPIで取得できませんでした。
その他の所属職名: リサーチマップAPIで取得できませんでした。
最近のエントリー: リサーチマップAPIで取得できませんでした。
Read会員ID: リサーチマップAPIで取得できませんでした。
経歴: リサーチマップAPIで取得できませんでした。
受賞: リサーチマップAPIで取得できませんでした。
Misc: リサーチマップAPIで取得できませんでした。
論文: リサーチマップAPIで取得できませんでした。
講演・口頭発表等: リサーチマップAPIで取得できませんでした。
書籍等出版物: リサーチマップAPIで取得できませんでした。
研究キーワード: リサーチマップAPIで取得できませんでした。
研究分野: リサーチマップAPIで取得できませんでした。
所属学協会: リサーチマップAPIで取得できませんでした。
担当経験のある科目: リサーチマップAPIで取得できませんでした。
その他: リサーチマップAPIで取得できませんでした。
Works: リサーチマップAPIで取得できませんでした。
特許: リサーチマップAPIで取得できませんでした。
学歴: リサーチマップAPIで取得できませんでした。
委員歴: リサーチマップAPIで取得できませんでした。
社会貢献活動: リサーチマップAPIで取得できませんでした。

ＫＡＫＥＮで最新データを確認する

2024年11月9日更新

研究者番号: 70710565

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授

所属（過去の研究課題 情報に基づく）*注記: 2020/4/1 – 2023/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 特任准教授
2020/4/1 : 徳島大学, 医歯薬学研究部(医学域), 特任准教授
2018/4/1 – 2019/4/1 : 徳島大学, 病院, 助教
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 助教
2015/4/1 – 2016/4/1 : 徳島大学, 大学院医歯薬学研究部, 助教
2014/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任助教
2013/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 特任助教

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 内科系臨床医学 / 神経内科学
生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学
小区分56010:脳神経外科学関連

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 脳神経外科学
生物系 / 総合生物 / 神経科学 / 神経解剖学・神経病理学
小区分52020:神経内科学関連

キーワード

研究代表者

NFκB / リン酸化タンパク質 / 線条体 / 機能分画 / パーキンソン病 / ジスキネジア / 不随意運動症 / c-fos / motor stereotypy / 線条体機能分画 / ドパミン / 常同症 / ハンチントン舞踏病 / ストリオソーム / 脳深部刺激療法 / 動物モデル / 不随意運動 / ジストニア / 脳神経疾患 / 神経科学 / シグナル伝達 / げっ歯類 / 治療法 / 線条体ストリオソーム分画 / 脳内ネットワーク / パルブアルブミン / 小脳 / 発症機序 / パルブアルブミン介在ニューロン / ストリオゾーム / ウィルスベクター / オプトジェネティクス / 大脳基底核

研究代表者以外

脳・神経 / 脳血管病 / エストロゲン / 脳動脈瘤破裂 / 血行動態変化 / 高血圧 / 結構動態変化 / 脳血管障害 / くも膜下出血 / 破裂脳動脈瘤 / 高塩食 / 神経変性疾患 / ジストニア / 神経病理 / 線条体 / ストリオソーム / マトリックス / ドパミン / 機能解剖 / パーキンソニズム / 画像診断 / FDG-PET / パーキンソン病 / DBS / PET / functional MRI / Diffusion tensor image / 難治性運動異常症 / 脳深部刺激療法 / DTI / バイオマーカー / dystonia / dopamine D1 receptor / striosome / D1レセプター / genetics / mouse model

研究課題研究成果共同研究者

「研究課題をさがす」で表示
テキスト（CSV）で出力

テキスト（CSV）で出力

2019年11月12日

パーキンソン病治療における脳内薬物インフュージョンシステムの開発（後藤惠）

後藤惠森垣龍馬牟礼英生笠原二郎梶龍兒永廣信治

2021年3月25日

人工知能技術に基づく個々の病態に最適化された治療的介入技法（AI-Based Behavior Modification: AiBM）の創出

山本哲也大森哲郎中瀧理仁内海千種牟礼英生森垣龍馬藤田浩司宮本亮介

研究者を探す

森垣 龍馬

Ｊグローバル

リサーチマップ

研究代表者

研究代表者以外

研究代表者

研究代表者以外

森垣龍馬